Personnel Information

写真a

OKAMOTO Tsukasa


Job title

Associate Professor

Research Areas, Keywords

pulmonary fibrosis, hypersensitivity pneumonitis, complement, Muc5b, KL-6

Graduating School 【 display / non-display

  • Hiroshima University, Faculty of Medicine, 2004.03, Graduated

Campus Career 【 display / non-display

  • 2013.04
    -
    2017.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Pulmonary Medicine, Assistant Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Pulmonary Medicine, Assistant Professor
  • 2019.04
    -
    2019.10
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Pulmonary Medicine, Assistant Professor
  • 2019.11
    -
    2020.09
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Internal Medicine, Pulmonary Medicine, Assistant Professor
  • 2020.10
    -
    2023.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Pulmonary Immunotherapeutics, Associate Professor
  • 2023.10
    -
    Now
    Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Integrated Facilities, Center for Personalized Medicine for Healthy Aging, Associate Professor

▼display all

External Career 【 display / non-display

  • 2015.04
    -
    2019.03
    University of Colorado, Department of Medicine, Visiting Research Associate

Academic Society Affiliations 【 display / non-display

  • American Thoracic Society

Research Areas 【 display / non-display

  • Respiratory medicine

Qualification Acquired 【 display / non-display

  • Doctor

  • TOEFL

 

Research Theme 【 display / non-display

  • The pathology of hypersensitivity pneumonitis, 2008.04 - Now

  • Pulmonary fibrosis and Muc5b

  • Lung injury and complement activation, 2015.04 - Now

Published Papers & Misc 【 display / non-display

  1. Endo S, Okamoto T, Kawahara T, Anzai T, Takahashi K, Miyazaki Y. Effect of warm and humid days on the positivity rate of anti-Trichosporon asahii antibody test for the diagnosis of summer-type hypersensitivity pneumonitis. Respiratory investigation. 2023.12; 62 (1): 150-156. ( PubMed, DOI )

  2. Aoki H, Miyazaki Y, Anzai T, Yokoyama K, Tsuchiya J, Shirai T, Shibata S, Sakakibara R, Mitsumura T, Honda T, Furusawa H, Okamoto T, Tateishi T, Tamaoka M, Yamamoto M, Takahashi K, Tateishi U, Yamaguchi T. Deep convolutional neural network for differentiating between sarcoidosis and lymphoma based on [(18)F]FDG maximum-intensity projection images. European radiology. 2023.08; 34 (1): 374-383. ( PubMed, DOI )

  3. Maruyama S, Furusawa H, Endo S, Kumagai T, Mitsumura T, Shimada S, Yamana T, Sakakibara R, Iijima Y, Shibata S, Honda T, Shirai T, Okamoto T, Tateishi T, Tamaoka M, Kinowaki Y, Ishibashi H, Okubo K, Miyazaki Y. Pulmonary Artery Aneurysm in a Patient with Nontuberculous Mycobacteria Infection. Internal medicine (Tokyo, Japan). 2023.08; ( PubMed, DOI )

  4. Yamashita Shohei, Okamoto Tsukasa, Kawahara Tatsuo, Tateishi Tomoya, Anzai Tatsuhiko, Takahashi Kunihiko, Fushimi Kiyohide, Miyazaki Yasunari. Database analysis of hypersensitivity pneumonitis in Japan(タイトル和訳中) Respiratory Investigation. 2023.03; 61 (2): 172-180. ( ichushi )

  5. Ikeda Tokuji, Ichiba Shingo, Sasaki Takashi, Sato Masaaki, Konoeda Chihiro, Okamoto Tsukasa, Miyazaki Yasunari, Nakajima Jun, Sakamoto Atsuhiro. A case of severe respiratory failure due to interstitial pneumonia successfully bridged to lung transplantation from a brain-dead donor using 109-day veno-arterial extracorporeal membrane oxygenation(タイトル和訳中) Journal of Artificial Organs. 2023.03; 26 (1): 84-88. ( ichushi )

  6. Tateishi T, Shimada S, Yamana T, Iijima Y, Sakakibara R, Mitsumura T, Shibata S, Honda T, Shirai T, Okamoto T, Tamaoka M, Sasai T, Miyazaki Y. COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease: A Case Report. Internal medicine (Tokyo, Japan). 2023.02; 62 (9): 1323-1328. ( PubMed, DOI )

  7. Yamashita S, Okamoto T, Kawahara T, Tateishi T, Anzai T, Takahashi K, Fushimi K, Miyazaki Y. Database analysis of hypersensitivity pneumonitis in Japan. Respiratory investigation. 2023.01; 61 (2): 172-180. ( PubMed, DOI )

  8. Peljto AL, Blumhagen RZ, Walts AD, Cardwell J, Powers J, Corte TJ, Dickinson JL, Glaspole I, Moodley YP, Vasakova MK, Bendstrup E, Davidsen JR, Borie R, Crestani B, Dieude P, Bonella F, Costabel U, Gudmundsson G, Donnelly SC, Egan J, Henry MT, Keane MP, Kennedy MP, McCarthy C, McElroy AN, Olaniyi JA, O'Reilly KMA, Richeldi L, Leone PM, Poletti V, Puppo F, Tomassetti S, Luzzi V, Kokturk N, Mogulkoc N, Fiddler CA, Hirani N, Jenkins G, Maher TM, Molyneaux PL, Parfrey H, Braybrooke R, Blackwell TS, Jackson PD, Nathan SD, Porteous MK, Brown KK, Christie JD, Collard HR, Eickelberg O, Foster EE, Gibson KF, Glassberg M, Kass D, Kropski JA, Lederer D, Linderholm AL, Loyd J, Mathai SK, Montesi SB, Noth I, Oldham JM, Palmisciano AJ, Reichner CA, Rojas M, Roman J, Schluger N, Shea BS, Swigris JJ, Wolters PJ, Zhang Y, Prele CMA, Enghelmayer JI, Otaola M, Ryerson CJ, Salinas M, Sterclova M, Gebremariam TH, Myllärniemi M, Carbone R, Furusawa H, Hirose M, Inoue Y, Miyazaki Y, Ohta K, Ohta S, Okamoto T, Kim DS, Pardo A, Selman M, Aranda AU, Park MS, Park JS, Song JW, Molina-Molina M, Planas-Cerezales L, Westergren-Thorsson G, Smith AV, Manichaikul AW, Kim JS, Rich SS, Oelsner EC, Barr RG, Rotter JI, Dupuis J, O'Connor G, Vasan RS, Cho MH, Silverman EK, Schwarz MI, Steele MP, Lee JS, Yang IV, Fingerlin TE, Schwartz DA, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants. American journal of respiratory and critical care medicine. 2023.01; 207 (9): 1194-1202. ( PubMed, DOI )

  9. Okada K, Sakakibara R, Honda T, Mitsumura T, Shibata S, Shirai T, Okamoto T, Furusawa H, Tateishi T, Miyazaki Y. Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report. Respiratory medicine case reports. 2023; 46 101929. ( PubMed, DOI )

  10. Chida-Nagai A, Masaki N, Maeda K, Sasaki K, Sato H, Muneuchi J, Ochiai Y, Murayama H, Tahara M, Shiono A, Shinozuka A, Kono F, Machida D, Toyooka S, Sugimoto S, Nakamura K, Akagi S, Kondo M, Kasahara S, Kotani Y, Koizumi J, Oda K, Harada M, Nakajima D, Murata A, Nagata H, Yatsunami K, Kobayashi T, Matsunaga Y, Inoue T, Yamagishi H, Nakagawa N, Ohtani K, Yamamoto M, Ito Y, Hokosaki T, Kuwahara Y, Masutani S, Nomura K, Wada T, Sawada H, Abiko M, Takahashi T, Ishikawa Y, Okada S, Naitoh A, Toda T, Ando T, Masuzawa A, Hoshino S, Kawada M, Nomura Y, Ueno K, Ohashi N, Tachibana T, Cao Y, Ueda H, Yanagi S, Koide M, Mitsushita N, Higashi K, Minosaki Y, Hayashi T, Okamoto T, Kuraishi K, Ehara E, Ishida H, Horigome H, Murakami T, Takei K, Ishii T, Harada G, Hirata Y, Maeda J, Tatebe S, Ota C, Hayabuchi Y, Sakazaki H, Sasaki T, Hirono K, Suzuki S, Yasuda M, Takeda A, Sawai M, Miyaji K, Kitagawa A, Nakai Y, Kakimoto N, Agematsu K, Manabe A, Saiki Y. Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease. Frontiers in cardiovascular medicine. 2023; 10 1212882. ( PubMed, DOI )

  11. Okamoto T, Dobrinskikh E, Hennessy CE, Liu N, Schwarz MI, Evans CM, Fontenot AP, Yang IV, Schwartz DA. Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by <i>Saccharopolyspora rectivirgula</i>. American journal of physiology. Lung cellular and molecular physiology. 2022.09; 323 (3): L329-L337. ( PubMed, DOI )

  12. Mitsumura Takahiro, Okamoto Tsukasa, Tosaka Mizuho, Yamana Takashi, Shimada Sho, Iijima Yuki, Sakakibara Rie, Shibata Sho, Honda Takayuki, Shirai Tsuyoshi, Ishizuka Masahiro, Aiboshi Junichi, Furusawa Haruhiko, Tateishi Tomoya, Tamaoka Meiyo, Shigemitsu Hidenobu, Arai Hirokuni, Otomo Yasuhiro, Tohda Shuji, Anzai Tatsuhiko, Takahashi Kunihiko, Yasuda Shinsuke, Miyazaki Yasunari. Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases(タイトル和訳中) Japanese Journal of Infectious Diseases. 2022.09; 75 (5): 504-510. ( ichushi )

  13. Ikeda Tokuji, Ichiba Shingo, Sasaki Takashi, Sato Masaaki, Konoeda Chihiro, Okamoto Tsukasa, Miyazaki Yasunari, Nakajima Jun, Sakamoto Atsuhiro. A case of severe respiratory failure due to interstitial pneumonia successfully bridged to lung transplantation from a brain-dead donor using 109-day veno-arterial extracorporeal membrane oxygenation JOURNAL OF ARTIFICIAL ORGANS. 2022.06; 26 (1): 84-88. ( PubMed, DOI )

  14. Ejima M, Okamoto T, Suzuki T, Miyazaki Y. Role of serum surfactant protein-D as a prognostic predictor in fibrotic hypersensitivity pneumonitis. Respiratory investigation. 2022.05; 60 (3): 369-378. ( PubMed, DOI )

  15. Mitsumura T, Okamoto T, Tosaka M, Yamana T, Shimada S, Iijima Y, Sakakibara R, Shibata S, Honda T, Shirai T, Ishizuka M, Aiboshi J, Furusawa H, Tateishi T, Tamaoka M, Shigemitsu H, Arai H, Otomo Y, Tohda S, Anzai T, Takahashi K, Yasuda S, Miyazaki Y. SARS-CoV-2 RNA copy number is a factor associated with the mortality of COVID-19 and improves the predictive performance of mortality in severe cases. Japanese journal of infectious diseases. 2022.05; 75 (5): 504-510. ( PubMed, DOI )

  16. Endo S, Honda T, Kawahara T, Sakakibara R, Mitsumura T, Okamoto T, Miyazaki Y. Profile of metastatic lung cancer patients susceptible to development of thromboembolism during immunotherapy. Cancer treatment and research communications. 2022; 31 100547. ( PubMed, DOI )

  17. Murakami T, Iijima Y, Ando T, Ejima M, Shirai T, Furusawa H, Okamoto T, Tateishi T, Tamaoka M, Miyazaki Y. Successful diagnosis of humidifier lung by individual provocation test to a responsible environment, a case report. Respiratory medicine case reports. 2022; 37 101639. ( PubMed, DOI )

  18. Suzuki Takafumi, Okamoto Tsukasa, Akiyama Masako, Honda Takayuki, Ejima Masaru, Ishizuka Masahiro, Sakashita Hiroyuki, Miyazaki Yasunari. Cumulative Incidences of Lung Cancer in Various Interstitial Lung Diseases(タイトル和訳中) Journal of Medical and Dental Sciences. 2022; 69 11-19. ( ichushi )

  19. Yamana T, Okamoto T, Ishizuka M, Hanzawa S, Ejima M, Shibata S, Miyazaki Y. Correction: IL-17A-Secreting Memory γδ T Cells Play a Pivotal Role in Sensitization and Development of Hypersensitivity Pneumonitis. Journal of immunology (Baltimore, Md. : 1950). 2021.12; 207 (11): 2892. ( PubMed, DOI )

  20. Mitsumura T, Kumaki Y, Takahashi K, Matsudera S, Sakakibara R, Honda T, Ishizuka M, Iijima Y, Shirai T, Okamoto T, Tateishi T, Sakashita H, Miyake S, Ikeda S, Miyazaki Y. Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases. Thoracic cancer. 2021.08; ( PubMed, DOI )

  21. Katayanagi S, Setoguchi Y, Kitagawa S, Okamoto T, Miyazaki Y. Alternative Gene Expression by TOLLIP Variant Is Associated With Lung Function in Chronic Hypersensitivity Pneumonitis. Chest. 2021.08; 161 (2): 458-469. ( PubMed, DOI )

  22. Ejima Masaru, Okamoto Tsukasa, Suzuki Takafumi, Anzai Tatsuhiko, Takahashi Kunihiko, Miyazaki Yasunari. Efficacy of treatment with corticosteroids for fibrotic hypersensitivity pneumonitis: a propensity score-matched cohort analysis BMC PULMONARY MEDICINE. 2021.07; 21 (1): 243. ( PubMed, DOI )

  23. Mitsumura Takahiro, Okamoto Tsukasa, Shirai Tsuyoshi, Iijima Yuki, Sakakibara Rie, Honda Takayuki, Ishizuka Masahiro, Aiboshi Junichi, Tateishi Tomoya, Tamaoka Meiyo, Shigemitsu Hidenobu, Arai Hirokuni, Otomo Yasuhiro, Tohda Shuji, Anzai Tatsuhiko, Takahashi Kunihiko, Yasuda Shinsuke, Miyazaki Yasunari. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia(和訳中) Journal of Infection and Chemotherapy. 2021.06; 27 (6): 857-863. ( ichushi )

  24. Tateishi T., Okamoto T., Takasawa S., Aoki H., Miyazaki Y.. Angiopoietin-1 Has a Protective Role in Acute Exacerbation of Interstitial Pneumonia AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.05; 203 (9):

  25. Tasaka Y, Honda T, Nishiyama N, Tsutsui T, Saito H, Watabe H, Shimaya K, Mochizuki A, Tsuyuki S, Kawahara T, Sakakibara R, Mitsumura T, Okamoto T, Kobayashi M, Chiaki T, Yamashita T, Tsukada Y, Taki R, Jin Y, Sakashita H, Natsume I, Saitou K, Miyashita Y, Miyazaki Y. Non-inferior clinical outcomes of immune checkpoint inhibitors in non-small cell lung cancer patients with interstitial lung disease. Lung Cancer (Amsterdam, Netherlands). 2021.03; 155 120-126. ( PubMed, DOI )

  26. Mitsumura T, Okamoto T, Shirai T, Iijima Y, Sakakibara R, Honda T, Ishizuka M, Aiboshi J, Tateishi T, Tamaoka M, Shigemitsu H, Arai H, Otomo Y, Tohda S, Anzai T, Takahashi K, Yasuda S, Miyazaki Y. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021.02; ( PubMed, DOI )

  27. Iijima Yuki, Okamoto Tsukasa, Shirai Tsuyoshi, Mitsumura Takahiro, Sakakibara Rie, Honda Takayuki, Ishizuka Masahiro, Tateishi Tomoya, Tamaoka Meiyo, Aiboshi Junichi, Otomo Yasuhiro, Anzai Tatsuhiko, Takahashi Kunihiko, Miyazaki Yasunari. MuLBSTA score is a useful tool for predicting COVID-19 disease behavior(和訳中) Journal of Infection and Chemotherapy. 2021.02; 27 (2): 284-290. ( ichushi )

  28. Oba S, Hosoya T, Amamiya M, Mitsumura T, Kawata D, Sasaki H, Kamiya M, Yamamoto A, Ando T, Shimada S, Shirai T, Okamoto T, Tateishi T, Endo A, Aiboshi J, Nosaka N, Yamanouchi H, Ugawa T, Nagaoka E, Oi K, Tao S, Maejima Y, Tanaka Y, Tanimoto K, Takeuchi H, Tohda S, Hirakawa A, Sasano T, Arai H, Otomo Y, Miyazaki Y, Yasuda S. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Frontiers in cardiovascular medicine. 2021; 8 767074. ( PubMed, DOI )

  29. Gally F, Sasse SK, Kurche J, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion O, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant, rs35705950, resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2020.12; 6 (2): e144294. ( PubMed, DOI )

  30. Okamato Y, Ghosh T, Okamoto T, Schuyler RP, Seifert J, Charry LL, Visser A, Feser M, Fleischer C, Pedrick C, August J, Moss L, Bemis EA, Norris JM, Kuhn KA, Demoruelle MK, Deane KD, Ghosh D, Holers VM, Hsieh EWY. Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes. Journal of Autoimmunity. 2020.12; 117 102581. ( PubMed, DOI )

  31. Yamana T, Okamoto T, Ishizuka M, Hanzawa S, Ejima M, Shibata S, Miyazaki Y. IL-17A-Secreting Memory γδ T Cells Play a Pivotal Role in Sensitization and Development of Hypersensitivity Pneumonitis. Journal of immunology (Baltimore, Md. : 1950). 2020.12; ( PubMed, DOI )

  32. Inoue Yukihisa, Okamoto Tsukasa, Honda Takayuki, Nukui Yoshihisa, Akashi Takumi, Takemura Tamiko, Tozuka Minoru, Miyazaki Yasunari. Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis IMMUNITY INFLAMMATION AND DISEASE. 2020.12; 8 (4): 659-671. ( PubMed, DOI )

  33. Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA. Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures. American Journal of Respiratory and Critical Care Medicine. 2020.11; 202 (10): 1430-1444. ( PubMed, DOI )

  34. Iijima Y, Okamoto T, Shirai T, Mitsumura T, Sakakibara R, Honda T, Ishizuka M, Tateishi T, Tamaoka M, Aiboshi J, Otomo Y, Anzai T, Takahashi K, Miyazaki Y. MuLBSTA score is a useful tool for predicting COVID-19 disease behavior. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2020.10; ( PubMed, DOI )

  35. Iijima Y, Sakakibara R, Ishizuka M, Honda T, Shirai T, Okamoto T, Tateishi T, Sakashita H, Tamaoka M, Takemoto A, Kumaki Y, Ikeda S, Miyazaki Y. Notable response to nivolumab during the treatment of SMARCA4-deficient thoracic sarcoma: a case report. Immunotherapy. 2020.06; 12 (8): 563-569. ( PubMed, DOI )

  36. Shirai T, Mitsumura T, Aoyagi K, Okamoto T, Kimura M, Gemma T, Shigematsu T, Takahashi J, Azuma S, Yoshizuka R, Sasaki H, Urushibata N, Ochiai K, Hondo K, Morishita K, Aiboshi J, Otomo Y, Miyazaki Y. COVID-19 pneumonia complicated by bilateral pneumothorax: A case report. Respiratory medicine case reports. 2020; 31 101230. ( PubMed, DOI )

  37. Furusawa, H; Cardwell, J; Okamoto, T; Walts, A; Konigsberg, IR; Kurche, JS; Bang, TJ; Schwarz, MI; Cool, CD; Brown, KK; Wolters, PJ; Lee, JS; Yang, IV; Schwartz, DA. Chronic Hypersensitivity Pneumonitis (CHP), an Interstitial Lung Disease (ILD) with Distinct Molecular Signatures AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020; 201

  38. Kurche JS, Dobrinskikh E, Hennessy CE, Huber J, Estrella A, Hancock LA, Schwarz MI, Okamoto T, Cool CD, Yang IV, Evans CM, Schwartz DA. Muc5b Enhances Murine Honeycomb-like Cyst Formation. American journal of respiratory cell and molecular biology. 2019.10; 61 (4): 544-546. ( PubMed, DOI )

  39. Kurche Jonathan S., Dobrinskikh Evgenia, Hennessy Corinne E., Huber Jonathan, Estrella Alani, Hancock Laura A., Schwarz Marvin I., Okamoto Tsukasa, Cool Carlyne D., Yang Ivana V., Evans Christopher M., Schwartz David A.. Muc5b Enhances Murine Honeycomb-like Cyst Formation AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2019.10; 61 (4): 544-546.

  40. Nukui Yoshihisa, Miyazaki Yasunari, Masuo Masahiro, Okamoto Tsukasa, Furusawa Haruhiko, Tateishi Tomoya, Kishino Mitsuhiro, Tateishi Ukihide, Ono Junya, Ohta Shoichiro, Izuhara Kenji, Inase Naohiko. Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis(和訳中) Allergology International. 2019.07; 68 (3): 363-369. ( ichushi )

  41. Camille Moore, Rachel Z Blumhagen, Ivana V Yang, Avram Walts, Julie Powers, Tarik Walker, Makenna Bishop, Pamela Russell, Brian Vestal, Jonathan Cardwell, Cheryl R Markin, Susan K Mathai, Marvin I Schwarz, Mark P Steele, Joyce Lee, Kevin K Brown, James E Loyd, James D Crapo, Edwin K Silverman, Michael H Cho, Judith A James, Joel M Guthridge, Joy D Cogan, Jonathan A Kropski, Jeffrey J Swigris, Carol Bair, Dong Soon Kim, Wonjun Ji, Hocheol Kim, Jin Woo Song, Lisa A Maier, Karin A Pacheco, Nikhil Hirani, Azin S Poon, Feng Li, R Gisli Jenkins, Rebecca Braybrooke, Gauri Saini, Toby M Maher, Philip L Molyneaux, Peter Saunders, Yingze Zhang, Kevin F Gibson, Daniel J Kass, Mauricio Rojas, John Sembrat, Paul J Wolters, Harold R Collard, John S Sundy, Thomas O'Riordan, Mary E Strek, Imre Noth, Shwu-Fan Ma, Mary K Porteous, Maryl E Kreider, Namrata B Patel, Yoshikazu Inoue, Masaki Hirose, Toru Arai, Shinobu Akagawa, Oliver Eickelberg, Isis Enlil Fernandez, Jürgen Behr, Nesrin Mogulkoc, Tamera J Corte, Ian Glaspole, Sara Tomassetti, Claudia Ravaglia, Venerino Poletti, Bruno Crestani, Raphael Borie, Caroline Kannengiesser, Helen Parfrey, Christine Fiddler, Doris Rassl, Maria Molina-Molina, Carlos Machahua, Ana Montes Worboys, Gunnar Gudmundsson, Helgi J Isaksson, David J Lederer, Anna J Podolanczuk, Sydney B Montesi, Elisabeth Bendstrup, Vivi Danchel, Moises Selman, Annie Pardo, Michael T Henry, Michael P Keane, Peter Doran, Martina Vašáková, Martina Sterclova, Christopher J Ryerson, Pearce G Wilcox, Tsukasa Okamoto, Haruhiko Furusawa, Yasunari Miyazaki, Geoffrey Laurent, Svetlana Baltic, Cecilia Prele, Yuben Moodley, Barry S Shea, Ken Ohta, Maho Suzukawa, Osamu Narumoto, Steven D Nathan, Drew C Venuto, Merte L Woldehanna, Nurdan Kokturk, Joao A de Andrade, Tracy Luckhardt, Tejaswini Kulkarni, Francesco Bonella, Seamas C Donnelly, Aoife McElroy, Michelle E Armstrong, Alvaro Aranda, Roberto G Carbone, Francesco Puppo, Kenneth B Beckman, Deborah A Nickerson, Tasha E Fingerlin, David A Schwartz. Resequencing Study Confirms Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory Critical Care Medicine. 2019.04; ( PubMed, DOI )

  42. Yoshihisa Nukui, Yasunari Miyazaki, Masahiro Masuo, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi, Mitsuhiro Kishino, Ukihide Tateishi, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Naohiko Inase. Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis. Allergollogy International. 2019.03; ( PubMed, DOI )

  43. Tsukasa Okamoto, Susan K Mathai, Corinne E Hennessy, Laura A Hancock, Avram D Walts, Adrianne L Stefanski, Kevin K Brown, David A Lynch, Gregory P Cosgrove, Steve D Groshong, Carlyne D Cool, Marvin I Schwarz, Nirmal K Banda, Joshua M Thurman, Ivana V Yang, V Michael Holers, David A Schwartz. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. American Journal of Physiology Lung Cell Mollecular Physiology. 2018.07; 315 (1): L1-L10. ( PubMed, DOI )

  44. Nukui Yoshihisa, Miyazaki Yasunari, Suhara Kozo, Okamoto Tsukasa, Furusawa Haruhiko, Inase Naohiko. IDENTIFICATION OF APOLIPOPROTEIN A-I IN BALF AS A BIOMARKER OF SARCOIDOSIS SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2018; 35 (1): 5-15.

  45. Nukui Y, Miyazaki Y, Suhara K, Okamoto T, Furusawa H, Inase N. Identification of apolipoprotein A-I in BALF as a biomarker of sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 2018; 35 (1): 5-15. ( PubMed, DOI )

  46. Okamoto, T; Evans, CM; Hennessy, CE; Schwarz, MI; Dobrinskikh, E; Fontenot, AP; Yang, IV; Schwartz, DA. Muc5b Expression Is Increased in a Murine Model of Hypersensitivity Pneumonitis AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018; 197

  47. Richard J Allen, Joanne Porte, Rebecca Braybrooke, Carlos Flores, Tasha E Fingerlin, Justin M Oldham, Beatriz Guillen-Guio, Shwu-Fan Ma, Tsukasa Okamoto, Alison E John, Ma'en Obeidat, Ivana V Yang, Amanda Henry, Richard B Hubbard, Vidya Navaratnam, Gauri Saini, Norma Thompson, Helen L Booth, Simon P Hart, Mike R Hill, Nik Hirani, Toby M Maher, Robin J McAnulty, Ann B Millar, Philip L Molyneaux, Helen Parfrey, Doris M Rassl, Moira K B Whyte, William A Fahy, Richard P Marshall, Eunice Oballa, Yohan Bossé, David C Nickle, Don D Sin, Wim Timens, Nick Shrine, Ian Sayers, Ian P Hall, Imre Noth, David A Schwartz, Martin D Tobin, Louise V Wain, R Gisli Jenkins. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respiratory Medicine. 2017.11; 5 (11): 869-880. ( PubMed, DOI )

  48. Britney A Helling, Anthony N Gerber, Vineela Kadiyala, Sarah K Sasse, Brent S Pedersen, Lenore Sparks, Yasushi Nakano, Tsukasa Okamoto, Christopher M Evans, Ivana V Yang, David A Schwartz. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory Cell Molecular Biology. 2017.07; 57 (1): 91-99. ( PubMed, DOI )

  49. Kozo Suhara, Yasunari Miyazaki, Tsukasa Okamoto, Masahiro Ishizuka, Kimitake Tsuchiya, Naohiko Inase. Fragmented gelsolins are increased in rheumatoid arthritis-associated interstitial lung disease with usual interstitial pneumonia pattern. Allergollogy International. 2016.01; 65 (1): 88-95. ( PubMed, DOI )

  50. Sahoko Chiba, Kimitake Tsuchiya, Takumi Akashi, Masahiro Ishizuka, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi, Mitsuhiro Kishino, Yasunari Miyazaki, Ukihide Tateishi, Tamiko Takemura, Naohiko Inase. Chronic Hypersensitivity Pneumonitis With a Usual Interstitial Pneumonia-Like Pattern: Correlation Between Histopathologic and Clinical Findings. Chest. 2016; 149 (6): 1473-1481. ( PubMed, DOI )

  51. Tsukasa Okamoto, Mayumi Fujii, Haruhiko Furusawa, Kimitake Tsuchiya, Yasunari Miyazaki, Naohiko Inase. The usefulness of KL-6 and SP-D for the diagnosis and management of chronic hypersensitivity pneumonitis. Respiratory Medicine. 2015.12; 109 (12): 1576-1581. ( PubMed, DOI )

  52. Toshiharu Tsutsui, Yasunari Miyazaki, Tsukasa Okamoto, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase. Antigen avoidance tests for diagnosis of chronic hypersensitivity pneumonitis. Respiratory Investigation. 2015.09; 53 (5): 217-224. ( PubMed, DOI )

  53. Tsukasa Okamoto, Toshiharu Tsutsui, Kozo Suhara, Haruhiko Furusawa, Yasunari Miyazaki, Naohiko Inase. Seasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis. Sarcoidosis Vascular Diffuse Lung Disease. 2015.01; 31 (4): 364-367. ( PubMed )

  54. Kozo Suhara, Yasunari Miyazaki, Tsukasa Okamoto, Makito Yasui, Kimitake Tsuchiya, Naohiko Inase. Utility of immunological tests for bird-related hypersensitivity pneumonitis. Respiratory Investigation. 2015.01; 53 (1): 13-21. ( PubMed, DOI )

  55. Tsukasa Okamoto, Yasunari Miyazaki, Takashi Ogura, Kingo Chida, Nobuoki Kohno, Shigeru Kohno, Hiroyuki Taniguchi, Shinobu Akagawa, Yoshiro Mochizuki, Kohei Yamauchi, Hiroki Takahashi, Takeshi Johkoh, Sakae Homma, Kazuma Kishi, Soichiro Ikushima, Satoshi Konno, Michiaki Mishima, Ken Ohta, Yasuhiko Nishioka, Nobuyuki Yoshimura, Mitsuru Munakata, Kentaro Watanabe, Yoshihiro Miyashita, Naohiko Inase. Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respiratory Investigation. 2013.09; 51 (3): 191-199. ( PubMed, DOI )

  56. Tsukasa Okamoto, Yasunari Miyazaki, Makoto Tomita, Meiyo Tamaoka, Naohiko Inase. A familial history of pulmonary fibrosis in patients with chronic hypersensitivity pneumonitis. Respiration. 2013; 85 (5): 384-390. ( PubMed, DOI )

  57. Tsukasa Okamoto, Yasunari Miyazaki, Ryutaro Shirahama, Meiyo Tamaoka, Naohiko Inase. Proteome analysis of bronchoalveolar lavage fluid in chronic hypersensitivity pneumonitis. Allergollogy International. 2012.03; 61 (1): 83-92. ( PubMed, DOI )

  58. Tsukasa Okamoto, Yasunari Miyazaki, Yumi Sakakibara, Meiyo Tamaoka, Yuki Sumi, Naohiko Inase. Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. Journal of Medical and Dental Science. 2011.12; 58 (4): 123-126. ( PubMed )

  59. Ryutaro Shirahama, Yasunari Miyazaki, Tsukasa Okamoto, Naohiko Inase, Yasuyuki Yoshizawa. Proteome analysis of bronchoalveolar lavage fluid in lung fibrosis associated with systemic sclerosis. Allergollogy International. 2010.12; 59 (4): 409-415. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Ejima M, Okamoto T, Miyazaki Y. Therapeutic Efficacy of Corticosteroid and Predictors of Survival in Patients with Chronic Hypersensitivity Pneumonitis: A Single Center Cohort. American Thoracic Society 2020.05.15

  2. Okamoto T, Takasawa S, Mitsumura T, Suhara K, Ejima M, Miyazaki Y. Clinical Characteristics in Patients with Asymmetric Chronic Hypersensitivity Pneumonitis. American Thoracic Society 2020.05.15

  3. Tateishi T, Okamoto T, Miyazaki Y. Long-Term Tolerability of Antifibrotic Therapy for the Patients with Pulmonary Fibrosis After Acute Exacerbation. American Thoracic Society 2020.05.15

  4. Setoguchi Yasuhiro, Kitagawa Sayoko, Katayanagi Shinji, Okamoto T., Miyazaki Yasunari. SERUM GALECTIN-3 COULD BE USEFUL BIOMARKER TO KNOW PROGRESSION OF PULMONARY FIBROSIS. RESPIROLOGY 2019.11.14