Personnel Information

写真a

TABU Kouichi


Job title

Junior Associate Professor

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

Cancer, Stem cell, Microenvironment, Niche, Polymer, Biomaterial

Field Introduction URL

http://www.tmd.ac.jp/mri/scr/index.html

Graduating School 【 display / non-display

  • Hokkaido University, Faculty of Veterinary Medicine, 2004.03, Graduated

Graduate School 【 display / non-display

  • Hokkaido University, Doctor's Course, 2007.09, Completed

Campus Career 【 display / non-display

  • 2009.04
    -
    2012.03
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, JSPS Research Fellow
  • 2012.04
    -
    2014.08
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Project Assistant Professor
  • 2014.09
    -
    2021.03
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Assistant Professor
  • 2021.04
    -
    2022.04
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Junior Associate Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Division of Visionary Life Science, Department of Stem Cell Regulation, Junior Associate Professor

External Career 【 display / non-display

  • 2008.04
    -
    2009.03
    , Global COE Research Associate

Research Areas 【 display / non-display

  • Tumor biology

  • Chemical biology

  • Cell biology

  • Polymer chemistry

  • Molecular biology

  • Tumor diagnostics and therapeutics

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Published Papers & Misc 【 display / non-display

  1. Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga, Kouichi Tabu . A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells Inflammation and Regeneration. 2023.09; 43 (1): 46. ( PubMed, DOI )

  2. Tabu Kouichi, Taga Tetsuya. Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells Inflammation and Regeneration. 2022.11; 42 (1): 54. ( PubMed, DOI )

  3. Wenqian Wang, Kouichi Tabu, Alapati Aimaitijiang, Tetsuya Taga. Therapy-resistant nature of cancer stem cells in view of iron metabolism Inflammation and Regeneration. 2022.11; 42 (1): 34.

  4. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas Cells. 2022.06; 11 (13): 2054.

  5. Aimaitijiang Alapati, Tabu Kouichi, Wang Wenqian, Nobuhisa Ikuo, Taga Tetsuya. Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells GENES TO CELLS. 2022.01; 27 (1): 25-42. ( PubMed, DOI )

  6. Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Takeda S, Kato K. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Scientific Reports. 2021.02; 11 (1): 4220.

  7. Taga T and Tabu K. Glioma progression and recurrence involving maintenance and expansion strategies of glioma stem cells by organizing self-advantageous niche microenvironments. Inflammation and Regeneration. 2020.09; 40 33. ( DOI )

  8. Tabu K, Liu W, Kosaku A, Terashima K, Murota Y, Aimaitijiang A, Nobuhisa I, Hide T, Taga T. Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages. Stem cells (Dayton, Ohio). 2020.08; 38 (8): 921-935. ( PubMed, DOI )

  9. Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, and Taga T. A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( DOI )

  10. Kokubu Y, Tabu K, Wang W, Muramatsu N, Murota Y, Nobuhisa I, Jinushi M, and Taga T. Induction of protumoral CD11chigh macrophages by glioma cancer stem cells through GM-CSF. Genes to Cells. 2016.03; 21 241-251. ( DOI )

  11. Inagaki T, Kusunoki S, Tabu K, Okabe H, Yamada I, Taga T, Matsumoto A, Makino S, Takeda S, Kato K.. Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo. Hum Cell. 2016.01; 29 10-21.

  12. Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, Taga T. A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem cells (Dayton, Ohio). 2014.06; 32 (6): 1602-15. ( PubMed, DOI )

  13. Kusunoki S, Kato K, Tabu K, Inagaki T, Okabe H, Kaneda H, Suga S, Terao Y, Taga T, Takeda S. The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecologic oncology. 2013.06; 129 (3): 598-605. ( PubMed, DOI )

  14. Tabu K, Bizen N, Taga T, Tanaka S. Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues. Advances in experimental medicine and biology. 2013; 777 73-85. ( PubMed, DOI )

  15. Kimura T, Wang L, Tabu K, Nishihara H, Mashita Y, Kikuchi N, Tanino M, Hiraga H, Tanaka S. CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma. Cancer investigation. 2012.06; 30 (5): 390-7. ( PubMed, DOI )

  16. Tanino M, Kohsaka S, Kimura T, Tabu K, Nishihara H, Sawa H, Kawami H, Kamada H, Shimizu M, Tanaka S. A case of clear cell variant of solid-pseudopapillary tumor of the pancreas in an adult male patient. Annals of diagnostic pathology. 2012.04; 16 (2): 134-40. ( PubMed, DOI )

  17. Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S. Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Molecular cancer. 2010.02; 9 39. ( PubMed, DOI )

  18. Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI. Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Laboratory investigation; a journal of technical methods and pathology. 2009.06; 89 (6): 645-56. ( PubMed, DOI )

  19. Tabu K, Sasai K, Kimura T, Wang L, Aoyanagi E, Kohsaka S, Tanino M, Nishihara H, Tanaka S. Promoter hypomethylation regulates CD133 expression in human gliomas. Cell research. 2008.10; 18 (10): 1037-46. ( PubMed, DOI )

  20. Nishihara H, Ozaki Y, Ito T, Yoshinaga T, Tabu K, Tanino M, Nagashima K, Tanaka S. A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. Brain tumor pathology. 2008.04; 25 (1): 45-9. ( PubMed, DOI )

  21. Wang L, Tabu K, Kimura T, Tsuda M, Linghu H, Tanino M, Kaneko S, Nishihara H, Tanaka S. Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4. Biochemical and biophysical research communications. 2007.11; 362 (4): 976-81. ( PubMed, DOI )

  22. Tabu K, Ohba Y, Suzuki T, Makino Y, Kimura T, Ohnishi A, Sakai M, Watanabe T, Tanaka S, Sawa H. Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA. Molecular cancer research : MCR. 2007.10; 5 (10): 1099-109. ( PubMed, DOI )

  23. Sasai K, Akagi T, Aoyanagi E, Tabu K, Kaneko S, Tanaka S. O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies. Molecular cancer. 2007.06; 6 36. ( PubMed, DOI )

  24. Tabu K, Ohnishi A, Sunden Y, Suzuki T, Tsuda M, Tanaka S, Sakai T, Nagashima K, Sawa H. A novel function of OLIG2 to suppress human glial tumor cell growth via p27Kip1 transactivation. Journal of cell science. 2006.04; 119 (Pt 7): 1433-41. ( PubMed, DOI )

  25. Asanuma T, Inanami O, Tabu K, Waki K, Kon Y, Kuwabara M. Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method. Neuroscience letters. 2004.04; 359 (1-2): 57-60. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Tarapongpun Tanakorn, Chuthapisith Suebwong, Onlamoon Nattawa, Kouichi Tabu, Yoshitaka Murota, Tetsuya Taga. Combinatorial Use of EGF and FGFs to Prime Human Adipose-derived Mesenchymal Stem Cells for Pre-adipocyte Commitment. 第18回生命医科学研究所ネットワーク国際シンポジウム 2023.10.06 Tokyo Medical and Dental University (TMDU), Tokyo

  2. Wenyu Liu, Kouichi Tabu, Yoshitaka Murota, Tetsuya Taga. Differential susceptibility of mouse adult neural stem cells and astrocytes to oncogenic transformation. The 82nd Annual Meeting of the Japanese Cancer Association 2023.09.23 PACIFICO Yokohama, Yokohama, Japan

  3. Tarapongpun Tanakorn, Chuthapisith Suebwong, Onlamoon Nattawa, Kouichi Tabu, Tetsuya Taga. Effect of Growth Factors on Priming Human Adipose-Derived Mesenchymal Stem Cells to Committed Preadipocytes Before Lipofilling. The 82nd Annual Meeting of the Japanese Cancer Association 2023.09.22 PACIFICO Yokohama, Yokohama, Japan

  4. Yoshitaka Murota, Shinji Tanaka, Tetsuya Taga, Kouichi Tabu. Niche-mimicking polymer hydrogel-based identification of fetuin-B as a potential target for pancreatic cancer. The 82nd Annual Meeting of the Japanese Cancer Association 2023.09.22 PACIFICO Yokohama, Yokohama, Japan

  5. Norihisa Bizen, Kouichi Tabu, Mei Wu, Christian Mangani, Rong Zhang, Mark Bradley, Tetsuya Taga . Development of synthetic polymer scaffolds mimicking a niche that maintains neural stem cells in a growth factor- and serum-free system. The 20th Stem Cell Research Symposium 2023.05.19 Awaji Yumebutai International Conference Center, Awaji, Japan

  6. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Establishment of a high-content polymer array screening system to explore niche mimicries for cancerous cells. The 17th International Symposium of the Institute Network for Biomedical Science International Symposium on Tumor Biology in Kanazawa 2022 2022.10.14 Cancer Research Institute of Kanazawa University, Kanazawa, Japan

  7. Kouichi Tabu, Shinji Kohsaka, Takuichiro Hide, Tetsuya Taga. Synthetic polymer microenvironment array chip based development of new cell phenomics for cancer stratification. The 81st Annual Meeting of the Japanese Cancer Association 2022.10.01 Pacifico Yokohama, Yokohama, Japan

  8. Tingting Zhang, Kouichi Tabuk, Yoshitaka Murota, Takuichiro Hide, Shunichiro Ogura, Tetsuya Taga. Exploration of glioma recurrence-related genes upregulated in highly invasive and 5-ALA-PDD escaping cells. The 81st Annual Meeting of the Japanese Cancer Association 2022.09.30 Pacifico Yokohama, Yokohama, Japan

  9. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Establishment of a high-content screening system for niche mimicries using polymer-immobilized microwell array plates. The 81st Annual Meeting of the Japanese Cancer Association 2022.09.30 Pacifico Yokohama, Yokohama, Japan

  10. Tetsuya Taga, Norihisa Bizen, Kouichi Tabu, Mei Wu, Christian Mangani, Rong Zhang, Mark Bradley. Identification of a niche-mimicking synthetic polymer scaffold that maintains neural stem cells in a growth factor- and serum-free system. The 19 th Stem Cell Research Symposium 2022.05.27 Awaji Yumebutai International Conference Center, Awaji, Japan

  11. Kouichi Tabu and Tetsuya Taga. Cancer stem cell niche-mimicking polymer-based exploration of the factors responsible for glioma recurrence. The 80th Annual Meeting of the Japanese Cancer Association 2021.10.01 PACIFICO Yokohama, Yokohama, Japan

  12. Kouichi Tabu, Tetsuya Taga. Polymer-based elucidation of molecular basis underlying cancer stem cell-mediated niche reconstruction and glioma recurrence. The 18th Stem Cell Research Symposium 2021.05.21

  13. Mariko Nagane, Kouichi Tabu, Yoshitaka Murota, Shinji Tanaka, Tetsuya Taga. Niche-mimicking polymer-based characterization of human pancreatic cancer stem cells (pCSCs). The 18th Stem Cell Research Symposium 2021.05.21

  14. Tabu K, Zhang S, Kosaku A, Venkateswaran S, Kohsaka S, Bradley M, Taga T . Synthetic polymer-based stratification of soft tissue sarcomas with different gene alterations and cells of origin. 11th World Biomaterials Congress (WBC Virtual 2020) 2020.12.11

  15. Nagane M, Tabu K, Murota Y, Tanaka S, Taga T. Fabrication of niche-mimicking polymer hydrogels to characterize human pancreatic cancer stem cells. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  16. Tabu K and Taga T. Chemical fabrication of bio-functional polymer-hydrogels that mimic cancer stem cell niche. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01

  17. Kosaku A, Tabu K, Kohsaka S, Taga T . A new stratification method for predicting chemosensitivities of soft tissue sarcomas using synthetic polymer microarray. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01

  18. Aimaitijiang A, Tabu K, Wang W, Nobuhisa I, Taga T. Glioma stem cells promote erythroid differentiation in mouse bone marrow. The 41st Annual Meeting of the Japanese Society of Inflammation and Regeneration 2020.07.08

  19. Tabu K, Wenyu L and Taga T. A self-expanding strategy of glioma stem cells via promoting the development of M1-like tumor-associated macrophages. . The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019.12.04 Fukuoka Convention Center, Fukuoka, Japan

  20. Tabu K and Taga T. Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  21. Aimaitijiang A, Tabu K and Taga. Glioma stem cells modulate erythropoiesis in mouse bone marrow. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  22. Tabu K and Taga T. Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  23. Aimaitijiang A, Tabu K and Taga T. Glioma stem cells modulate erythropoiesis in mouse bone marrow. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  24. Taga T and Tabu K. Exploration of molecular mechanisms regulating cancer stem cells and their niche. International Summer Program (ISP) 2019 2019.07.09 TMDU, Bunkyo-ku, Japan

  25. Taga T and Tabu K. Development of Treatment Strategies Targeting Cancer Stem Cells. The 3rd Meeting of International Society of Precision Cancer Medicine 2019.03.14 Seoul, Korea

  26. Tabu K and Taga T. A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance. The 77th Annual Meeting of the Japanese Cancer Association 2018.09.29 Osaka International Convention Center、Osaka

  27. Tabu K and Taga T. Identification of a subpopulation of glioma cells with a potential for tumor niche development involving myeloid cells. The 16th Stem Cell Research Symposium 2018.06.02 Centennial Hall, Kyushu University, Fukuoka, Japan

  28. Tabu K and Taga T. Abilities of cancer stem cells to organize the self-advantageous microenvironment niche. TMU-TMDU Joint Symposium 2018 2018.03.24 Tokyo Medical and Dental University, Tokyo, Japan

  29. Murota Y, Wenqing GY, Tabu K, and Taga T. Establishment of glioma mouse model by transducing oncogenic H-RasV12 gene into the p53 deficient astrocytes. The 76th Annual Meeting of the Japanese Cancer Association 2017.09.30 Pacifico Yokohama, Yokohama, Japan

  30. Tabu K, Wang W, Murota Y and Taga T. Self-expanding strategies of glioma stem cells that involves macrophages to adapt to iron-deprivation stress. The 76th Annual Meeting of the Japanese Cancer Association 2017.09.28 Pacifico Yokohama, Yokohama, Japan

  31. 田賀哲也、椨康一. 神経膠腫癌幹細胞の利己的生存戦略による癌の進展. 第38回日本 炎症・再生医学会 2017.07.18 大阪国際会議場、大阪

  32. Murota Y, Schmidt S, Tabu K, Ito H, Tanaka S, Bradley M and Taga T. Screening for human pancreatic cancer stem cell niche mimicry by using synthetic polymer microarrays. The 15th Stem Cell Research Symposium 2017.05.27 Tokyo University, Tokyo, Japan

  33. Tabu K and Taga T. Self-maintenance strategies of glioma stem cells (GSCs) involving GSC-induced protumoral macrophages. 11th International Symposium of The Institute Network 2017.01.27 Tokushima University, Tokushima, Japan

  34. Wang W, Tabu K, Hagiya Y, Murota Y, Ogura S and Taga T. Enhancement of 5-aminolevulinic acid-based fluorescence detection of glioma stem cells by chelating iron. The 75th Annual Meeting of the Japanese Cancer Association 2016.10.06 Pacifico Yokohama, Yokohama, Japan

  35. Tabu K, Wang W, Murota Y and Taga T. Adaptive response of C6 glioma stem cells to iron deprivation through macrophage induction. The 75th Annual Meeting of the Japanese Cancer Association 2016.10.06 Pacifico Yokohama, Yokohama, Japan

  36. Tabu K, Kokubu Y, Muramatsu N, Nomoto S, Wang W and Taga T. Adaptive response of rat C6 glioma stem cells to iron deprivation by which the development of tumor infiltrating macrophages is induced. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  37. Murota Y, Tabu K and Taga T. C6 glioma stem cell-derived extracellular vesicles promote the development of macrophages. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  38. Wang W, Tabu K, Sugiyama Y, Hagiya Y, Ogura S and Taga T. Resistance of glioma stem cells to 5-aminolevulinic acid (ALA)-based detection due to enhanced metabolic conversion of protoporphyrin IX. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  39. Tabu K, Muramatsu N, and Taga T. Synthetic polymer-based approach revealed an adaptive capacity of glioma stem cells by inducing tumor-infiltrating and iron-accumulating macrophages. The 38th Annual Meeting of the Molecular Biology Society of Japan 2015.12.01 Kobe International Conferance Center, Kobe, Japan

  40. Wang W, Tabu K, KokubuY, Hagiya Y, Ogura S, and Taga T. Splenic abnormal erythropoiesis in C6 glioma-bearing mice: an implication for their environment of cancer stem cells. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.08 Nagoya Congress Center, Nagoya, Japan

  41. Taga T and Tabu K. Characterization of C6 glioma cancer stem cells and their niche. Seoul National University, Cancer Research Institute (SNU CRI) Annual Symposium 2015 ‘Innovative Approaches to Explore Novel Druggable Targets’ 2015.04.01 Hwasun, Korea

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Others 【 display / non-display

  • Finding your niche: A synthetic cancer stem cell microenvironment,2023.11