Personnel Information

写真a

EBANA Yusuke


Job title

Junior Associate Professor

Research Areas, Keywords

Genetics, Cardiovascular disease, Medical ethics, Research ethics

Profile

M.D./Ph.D./Physician/Cardiologist/Medical Geneticist.
Specialty is cardiovascular diseases, arrhythmia, genetic diseases, and general internal medicine.
Ueda award winner of Japanese college of cardiology
Founder of Certified Research Ethics Committee Professional (CReP)
Twitter @ebnysk1

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Doctor's Course, Completed

Degree 【 display / non-display

  • M.D., Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1999.04
    -
    2001.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Trainee Resident
  • 2001.04
    -
    2007.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Senior Resident
  • 2007.04
    -
    2009.07
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Bio-informational Pharmacology, Project Assistant Professor
  • 2009.07
    -
    2015.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Molecular Cellular Cardiology, Assistant Professor
  • 2015.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Life Sciences and Bioethics, Junior Associate Professor
  • 2015.05
    -
    Now
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Life Science and Bioethics Research Center, Junior Associate Professor
  • 2015.05
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Medical Genetics, Junior Associate Professor
  • 2017.05
    -
    2020.09
    Tokyo Medical and Dental University, Institute of Research, Research Facility Cluster, Life Science and Bioethics Research Center, Junior Associate Professor
  • 2020.10
    -
    Now
    Tokyo Medical and Dental University, Institute of Research, Research Facility Cluster, Life Science and Bioethics Research Center, Junior Associate Professor

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External Career 【 display / non-display

  • 2015.05
    -
    Now
    , Project Researcher
  • 2015.05
    -
    Now
    , Visiting Lecturer

Academic Society Affiliations 【 display / non-display

  • Japanese circulation society

  • Japanese College of Cardiology

  • Japan Association for Bioethics

Research Areas 【 display / non-display

  • Medical biochemistry

  • Cardiology

  • Medical management and medical sociology

  • Philosophy and ethics

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Functional analysis and clinical study of atrial fibrillation-associated genes, 2011.04 - 2013.03

  • Identification and functional analysis of atrial fibrillation -associated loci through genomewide association study, 2009.04 - 2010.03

Published Papers & Misc 【 display / non-display

  1. Yusuke Ebana, Sou Hee Yang, Megumu Yokono, Masayuki Yoshida. Establishment of the Certified Research Ethics Professionals: An Ethical Review Expert -Translated in English from Japanese Version. JMA J. 2021.10; 4 (4): 405-408. ( PubMed, DOI )

  2. Ikeda Sadakatsu, Kudo Ryo, Yamashita Yamato, Noji Rika, Yokobori Jyunko, Ohki Mika, Takamine Eriko, Kobayashi Yumi, Egawa Makiko, Ebana Yusuke, Kimura Koichiro, Yokoyama Kohta, Onishi Iichiro, Takemoto Akira, Kirimura Susumu, Kinowaki Yuko, Tanimoto Kosuke, Miya Fuyuki, Kano Yoshihito, Yoshida Masayuki, Miyake Satoshi. . Clinical utility of multi-disciplinary expert panel discussion in precision cancer medicine ANNALS OF ONCOLOGY.. 2021.07; ( DOI )

  3. Myunghee Hong, Yusuke Ebana, Jaemin Shim, Eue-Keun Choi, Hong Euy Lim, Inseok Hwang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Seil Oh, Moon-Hyoung Lee, Young-Hoon Kim, Sun Ha Jee, Hui-Nam Pak. Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations. Eur J Clin Invest. 2021.05; e13584. ( PubMed, DOI )

  4. Xiaoxi Yang, Tetsuo Sasano, Yusuke Ebana, Jun K Takeuchi, Kensuke Ihara, Masahiro Yamazoe, Tetsushi Furukawa. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation. Circ J. 2020.10; ( PubMed, DOI )

  5. Yusuke Ebana, Yihan Sun, Xiaoxi Yang, Taiju Watanabe, Satoru Makita, Kouichi Ozaki, Toshihiro Tanaka, Hirokuni Arai, Tetsushi Furukawa. Pathway analysis with genome-wide association study (GWAS) data detected the association of atrial fibrillation with the mTOR signaling pathway. Int J Cardiol Heart Vasc. 2019.09; 24 100383. ( PubMed, DOI )

  6. Yusuke Ebana, Tetsushi Furukawa. Networking analysis on superior vena cava arrhythmogenicity in atrial fibrillation. Int J Cardiol Heart Vasc. 2019.03; 22 150-153. ( PubMed, DOI )

  7. Noriaki Yamada, Yoshihiro Asano, Masashi Fujita, Satoru Yamazaki, Atsushi Inanobe, Norio Matsuura, Hatasu Kobayashi, Seiko Ohno, Yusuke Ebana, Osamu Tsukamoto, Saki Ishino, Ayako Takuwa, Hidetaka Kioka, Toru Yamashita, Norio Hashimoto, Dimitar P Zankov, Akio Shimizu, Masanori Asakura, Hiroshi Asanuma, Hisakazu Kato, Yuya Nishida, Yohei Miyashita, Haruki Shinomiya, Nobu Naiki, Kenshi Hayashi, Takeru Makiyama, Hisakazu Ogita, Katsuyuki Miura, Hirotsugu Ueshima, Issei Komuro, Masakazu Yamagishi, Minoru Horie, Koichi Kawakami, Tetsushi Furukawa, Akio Koizumi, Yoshihisa Kurachi, Yasushi Sakata, Tetsuo Minamino, Masafumi Kitakaze, Seiji Takashima. Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. Circulation. 2019.02; ( PubMed, DOI )

  8. Yusuke Ebana, Junichi Nitta, Yoshihide Takahashi, Shinsuke Miyazaki, Masahito Suzuki, Lian Liu, Kenzo Hirao, Eiichiro Kanda, Mitsuaki Isobe, Tetsushi Furukawa. Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation. Circ. J.. 2017.12; 82 (1): 71-77. ( PubMed, DOI )

  9. Ebana Yusuke, Nitta Junichi, Takahashi Yoshihide, Miyazaki Shinsuke, Suzuki Masahito, Liu Lian, Hirao Kenzo, Kanda Eiichiro, Isobe Mitsuaki, Furukawa Tetsushi. Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation Circulation Journal. 2017.12; 82 (1): 71-77. ( ichushi )

  10. Takahashi Sayako, Terui-Kohbata Hiroko, Ebana Yusuke, Yoshida Masayuki. Analysis of the Present Recognition Toward a Central IRB (cIRB) System in Japanese Medical Schools JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS. 2017.12; 12 (5): 394-395.

  11. Shinsuke Miyazaki, Yusuke Ebana, Lian Liu, Hiroaki Nakamura, Hitoshi Hachiya, Hiroshi Taniguchi, Takamitsu Takagi, Takatsugu Kajiyama, Tomonori Watanabe, Miyako Igarashi, Shigeki Kusa, Takashi Niida, Yoshito Iesaka, Tetsushi Furukawa. Chromosome 4q25 variants and recurrence after second-generation cryoballoon ablation in patients with paroxysmal atrial fibrillation. Int. J. Cardiol.. 2017.10; 244 151-157. ( PubMed, DOI )

  12. Yusuke Ebana, Kouichi Ozaki, Lian Liu, Hitoshi Hachiya, Kenzo Hirao, Mitsuaki Isobe, Michiaki Kubo, Toshihiro Tanaka, Tetsushi Furukawa. Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25. J Cardiol. 2017.10; 70 (4): 366-373. ( PubMed, DOI )

  13. Ebana Yusuke, Ozaki Kouichi, Liu Lian, Hachiya Hitoshi, Hirao Kenzo, Isobe Mitsuaki, Kubo Michiaki, Tanaka Toshihiro, Furukawa Tetsushi. Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25 Journal of Cardiology. 2017.10; 70 (3-4): 366-373. ( ichushi )

  14. Siew-Kee Low, Atsushi Takahashi, Yusuke Ebana, Kouichi Ozaki, Ingrid E Christophersen, Patrick T Ellinor, , Soichi Ogishima, Masayuki Yamamoto, Mamoru Satoh, Makoto Sasaki, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Keitaro Tanaka, Mariko Naito, Kenji Wakai, Hideo Tanaka, Tetsushi Furukawa, Michiaki Kubo, Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nat. Genet.. 2017.06; 49 (6): 953-958. ( PubMed, DOI )

  15. Ohigashi Hirokazu, Tamura Natsuko, Ebana Yusuke, Harigai Masayoshi, Maejima Yasuhiro, Ashikaga Takashi, Isobe Mitsuaki. Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment Journal of Cardiology. 2017.06; 69 (5-6): 774-778. ( ichushi )

  16. Shintaro Akiyama, Toshimitsu Fujii, Katsuyoshi Matsuoka, Ebana Yusuke, Mariko Negi, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Mitsuaki Isobe, Mamoru Watanabe. Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis. J. Gastroenterol. Hepatol.. 2017.05; 32 (5): 1011-1017. ( PubMed, DOI )

  17. Ebana Yusuke. Impact of Clinical and Genetic Factors on Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation Japanese Circulation Society Scientific Meeting Abstracts. 2017.03; 81 OJ-114. ( ichushi )

  18. Ebana Yusuke. Precision Medicine Based on Genetic Information Combined Analysis Using GWAS and Array Data Detecting Associated Pathway and Shared Genomic Structure Japanese Circulation Society Scientific Meeting Abstracts. 2017.03; 81 SY14-3. ( ichushi )

  19. Furukawa Tetsushi, Liu Lian, Ebana Yusuke, Nitta Jun-ichi, Takahashi Yoshihida, Miyazaki Shinsuke, Komura Masatoshi, Tanaka Toshihiro, Isobe Mitsuaki. Genetic Background of Atrial Fibrillation Japanese Circulation Society Scientific Meeting Abstracts. 2017.03; 81 TP2-1. ( ichushi )

  20. Lian Liu, Yusuke Ebana, Jun-Ichi Nitta, Yoshihide Takahashi, Shinsuke Miyazaki, Toshihiro Tanaka, Masatoshi Komura, Mitsuaki Isobe, Tetsushi Furukawa. Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population. Can J Cardiol. 2016.11; ( PubMed, DOI )

  21. Hirokazu Ohigashi, Natsuko Tamura, Yusuke Ebana, Masayoshi Harigai, Yasuhiro Maejima, Takashi Ashikaga, Mitsuaki Isobe. Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment. J Cardiol. 2016.08; ( PubMed, DOI )

  22. Yoichi Otaki, Yusuke Ebana, Shunji Yoshikawa, Mitsuaki Isobe. Dielectric permittivity change detects the process of blood coagulation: Comparative study of dielectric coagulometry with rotational thromboelastometry. Thromb. Res.. 2016.06; 145 3-11. ( PubMed, DOI )

  23. Yuki Hasegawa, Satomi Hamada, Takuro Nishimura, Takeshi Sasaki, Yusuke Ebana, Mihoko Kawabata, Masahiko Goya, Mitsuaki Isobe, Takatoshi Koyama, Tetsushi Furukawa, Kenzo Hirao, Tetsuo Sasano. Novel Dielectric Coagulometer Identifies Hypercoagulability in Patients with a High CHADS2 Score without Atrial Fibrillation. PLoS ONE. 2016; 11 (6): e0156557. ( PubMed, DOI )

  24. Junko Kurokawa, Tetsuo Sasano, Masami Kodama, Min Li, Yusuke Ebana, Nobuhiro Harada, Shin-ichiro Honda, Haruaki Nakaya, Tetsushi Furukawa. Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters. J Toxicol Sci. 2015; 40 (3): 339-348. ( PubMed, DOI )

  25. Moritz F Sinner, Nathan R Tucker, Kathryn L Lunetta, Kouichi Ozaki, J Gustav Smith, Stella Trompet, Joshua C Bis, Honghuang Lin, Mina K Chung, Jonas B Nielsen, Steven A Lubitz, Bouwe P Krijthe, Jared W Magnani, Jiangchuan Ye, Michael H Gollob, Tatsuhiko Tsunoda, Martina Müller-Nurasyid, Peter Lichtner, Annette Peters, Elena Dolmatova, Michiaki Kubo, Jonathan D Smith, Bruce M Psaty, Nicholas L Smith, J Wouter Jukema, Daniel I Chasman, Christine M Albert, Yusuke Ebana, Tetsushi Furukawa, Peter W Macfarlane, Tamara B Harris, Dawood Darbar, Marcus Dörr, Anders G Holst, Jesper H Svendsen, Albert Hofman, Andre G Uitterlinden, Vilmundur Gudnason, Mitsuaki Isobe, Rainer Malik, Martin Dichgans, Jonathan Rosand, David R Van Wagoner, , , Emelia J Benjamin, David J Milan, Olle Melander, Susan R Heckbert, Ian Ford, Yongmei Liu, John Barnard, Morten S Olesen, Bruno H C Stricker, Toshihiro Tanaka, Stefan Kääb, Patrick T Ellinor. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014.10; 130 (15): 1225-1235. ( PubMed, DOI )

  26. Chikashi Terao, Hajime Yoshifuji, Akinori Kimura, Takayoshi Matsumura, Koichiro Ohmura, Meiko Takahashi, Masakazu Shimizu, Takahisa Kawaguchi, Zhiyong Chen, Taeko K Naruse, Aiko Sato-Otsubo, Yusuke Ebana, Yasuhiro Maejima, Hideyuki Kinoshita, Kosaku Murakami, Daisuke Kawabata, Yoko Wada, Ichiei Narita, Junichi Tazaki, Yasushi Kawaguchi, Hisashi Yamanaka, Kimiko Yurugi, Yasuo Miura, Taira Maekawa, Seishi Ogawa, Issei Komuro, Ryozo Nagai, Ryo Yamada, Yasuharu Tabara, Mitsuaki Isobe, Tsuneyo Mimori, Fumihiko Matsuda. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am. J. Hum. Genet.. 2013.08; 93 (2): 289-297. ( PubMed, DOI )

  27. Tetsushi Furukawa, MD, PhD, Yusuke Ebana, MD, PhD. Current overview of the genetic background of atrial fibrillation: Possible therapeutic gene targets for the treatment of atrial fibrillation Journal of Arrhythmia. 2012.06; 28 (3): 140-144.

  28. Chisato Takamura, Hirokazu Ohhigashi, Yusuke Ebana, Mitsuaki Isobe. New human leukocyte antigen risk allele in Japanese patients with Takayasu arteritis. Circ. J.. 2012.05; 76 (7): 1697-1702. ( PubMed )

  29. Yusuke Ebana, Kouichi Ozaki, Katsumi Inoue, Hiroshi Sato, Aritoshi Iida, Htay Lwin, Susumu Saito, Hiroya Mizuno, Atsushi Takahashi, Takahiro Nakamura, Yoshinari Miyamoto, Shiro Ikegawa, Keita Odashiro, Masakiyo Nobuyoshi, Naoyuki Kamatani, Masatsugu Hori, Mitsuaki Isobe, Yusuke Nakamura, Toshihiro Tanaka. A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction. J. Hum. Genet.. 2007; 52 (3): 220-229. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Yusuke Ebana. Educational Lecture "Genetic Basis of Inherited Arrhythmia Syndrome". The 12th Asia Pacific Heart Rhythm Society Scientific Session 2019.10.24

  2. Yusuke Ebana. Educational Lecture Genetic Testing 101, "Whom Should Be Tested?". The 12th Asia Pacific Heart Rhythm Society Scientific Session 2019.10.24

  3. Yusuke Ebana. Genetics of atrial fibrillation in Japanese Population. The 11th Asia Pacific Heart Rhythm Society Scientific Session 2018.10.15 Taipei, Taiwan

  4. Yusuke Ebana. Combined Analysis Using GWAS and Array Data Detecting Associated Pathway and Shared Genomic Structure. The 81st Annual Scientific Meeting of the Japanese Circulation Society 2017.03.17

  5. Yusuke Ebana Hiroko Kohbata, Sayako Takahashi, Masayuki Yoshida. Genetic counselling for a case with breast cancer who underwent a whole-exome sequencing in a private company. The 13th International Congress Society of Human Genetics 2016.04.06

  6. Yusuke Ebana1 Ozaki K2, Okada Y3, Ito S1, Tanaka T3, Isobe M4, Furukawa T1. A post-GWAS analysis, MAGENTA, identified novel pathways for atrial fibrillation. 第79回日本循環器学会学術集会 2015.04.24

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Awards & Honors 【 display / non-display

  • Ueda Award,Japanese College of Cardiology,2018.09

 

Campus class subject 【 display / non-display

  • Initial Research Training Program, Graduate School of Medical and Dental Science,2017 - Now

  • Cardiovascular Medicine,2017 - Now

  • Bioethics II,2015 - Now

  • Bioethics I,2015 - Now

  • Medical and Research Ethics,2015 - Now

External class subject 【 display / non-display

  • Bioethics, medical ethics

Performance of duties 【 display / non-display

  • ,2017.04 - 2020.03

  • ,2017.01 - 2020.03

  • ,2015.04 - 2017.03

  • ,2011.04 - 2013.03

  • ,2009.04 - 2011.03