Personnel Information

写真a

ISODA Takeshi


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • Ehime University, Faculty of Medicine, 2000.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2012.03, Completed

Campus Career 【 display / non-display

  • 2000.05
    -
    2001.03
    Tokyo Medical and Dental University, Trainee Resident
  • 2002.09
    -
    2005.03
    Tokyo Medical and Dental University, Senior Resident
  • 2006.04
    -
    2007.05
    Tokyo Medical and Dental University, Senior Resident
  • 2007.06
    -
    2007.12
    Tokyo Medical and Dental University, Assistant Professor
  • 2008.01
    -
    2008.03
    Tokyo Medical and Dental University, Senior Resident
  • 2008.04
    -
    2012.03
    Tokyo Medical and Dental University, Graduate Student
  • 2017.12
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Visiting Lecturer
  • 2018.04
    -
    2019.10
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Pediatrics, Maternal and Woman's Medicine, Pediatrics, Assistant Professor
  • 2019.11
    -
    2021.03
    Tokyo Medical and Dental University, (Old Organization)Medical Hospital, Hospital Departments, Department of Pediatrics, Maternal and Woman's Medicine, Pediatrics, Assistant Professor
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Junior Associate Professor

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External Career 【 display / non-display

  • 2001.04
    -
    2002.03
    , Trainee Resident
  • 2002.04
    -
    2002.08
    , Resident
  • 2005.04
    -
    2006.03
    , Resident

Research Areas 【 display / non-display

  • Genome biology

  • Molecular biology

  • Genetics

  • Embryonic medicine and pediatrics

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Yuichi Nagamatsu, Takeshi Isoda, Motoki Inaji, Jun Oyama, Daiki Niizato, Dan Tomomasa, Noriko Mitsuiki, Motoi Yamashita, Takahiro Kamiya, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi. Intracranial residual lesions following early intensification in a patient with T-cell acute lymphoblastic leukemia: a case report. BMC Pediatr. 2024.05; 24 (1): 304. ( PubMed, DOI )

  2. Masatoshi Takagi, Chihiro Tomoyasu, Junko Yamanaka, Takayuki Hamabata, Takeshi Isoda, Takako Miyamura, Kohsuke Imai. Immunological assessment of a patient with infant acute lymphoblastic leukemia. Pediatr Int. 2024.01; 66 (1): e15738. ( PubMed, DOI )

  3. Akira Nishimura, Kazuaki Yokoyama, Takuya Naruto, Chika Yamagishi, Toshihiko Imamura, Hiroto Nakazono, Shunsuke Kimura, Mieko Ito, Maiko Sagisaka, Yukie Tanaka, Jinhua Piao, Yui Namikawa, Masakatsu Yanagimachi, Takeshi Isoda, Akinori Kanai, Hirotaka Matsui, Tomoya Isobe, Aiko Sato-Otsubo, Naoko Higuchi, Akiko Takada, Haruna Okuno, Shoji Saito, Shuhei Karakawa, Shogo Kobayashi, Daisuke Hasegawa, Hiroyuki Fujisaki, Daiichiro Hasegawa, Kazutoshi Koike, Takashi Koike, Shinya Rai, Katsutsugu Umeda, Hideki Sano, Yujin Sekinaka, Atsushi Ogawa, Akitoshi Kinoshita, Norio Shiba, Mizuka Miki, Fumihiko Kimura, Hideki Nakayama, Yozo Nakazawa, Takashi Taga, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Katsuyoshi Koh, Yasushi Ishida, Junko Takita, Fumihiko Ishikawa, Hiroaki Goto, Tomohiro Morio, Shuki Mizutani, Arinobu Tojo, Masatoshi Takagi. Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type. Sci Adv. 2023.12; 9 (50): eadj4407. ( PubMed, DOI )

  4. Motoi Yamashita, Takahiro Tomoda, Ami Mizuo, Takeshi Isoda, Makiko Egawa, Masayuki Yoshida, Tsutomu Toki, Ko Kudo, Kiminori Terui, Etsuro Ito, Tomohiro Morio, Masatoshi Takagi. Transient erythroblastopenia due to a GATA1 variant in an infant female. Pediatr Blood Cancer. 2023.12; e30834. ( PubMed, DOI )

  5. Niiyama S, Fukuda H, Hirata A, Takenaka S, Isoda T. Recalcitrant multiple warts in GATA2 deficiency treated with systemic etretinate. The Journal of dermatology. 2023.08; ( PubMed, DOI )

  6. Nishiyama Y, Mizuki K, Hoshino A, Hirabayashi S, Magara T, Ashiarai M, Miyamoto S, Ono R, Takahashi S, Hosoya Y, Niizato D, Yoshihara H, Nishimura A, Mitsuiki N, Kamiya T, Takasawa K, Kajiwara M, Kanegane H, Morio T, Manabe A, Isoda T, Hasegawa D, Takagi M. Hematopoietic cell transplantation for hematological malignancies in Bloom syndrome. Pediatric blood & cancer. 2023.08; 70 (11): e30655. ( PubMed, DOI )

  7. Motoi Yamashita, Masae Kuroha, Yuko Kinowawki, Nao Kashiwagi, Kotaro Watanabe, Mika Nagase, Daiki Niizato, Noriko Mitsuiki, Takeshi Isoda, Takahiro Kamiya, Atsuko Arisaka, Motoki Inaji, Kenichi Ohashi, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi. A SAMD5-SASH1 fusion in solitary infantile myofibromatosis. Pediatr Blood Cancer. 2023.03; 70 (6): e30278. ( PubMed, DOI )

  8. Dan Tomomasa, Takeshi Isoda, Noriko Mitsuiki, Kento Inoue, Akira Nishimura, Kazuhiro Uda, Toru Uchiyama, Motoi Yamashita, Takahiro Kamiya, Akifumi Endo, Masatoshi Takagi, Kohsuke Imai, Michiko Kajiwara, Morton J Cowan, Tomohiro Morio, Hirokazu Kanegane. Successful TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for a Patient With Artemis Deficiency. J Pediatr Hematol Oncol. 2023.02; 45 (2): E285-E289. ( PubMed, DOI )

  9. Takeru Kanazawa, Tatsuyuki Ishida, Madoka Shirai, Daiki Niizato, Takeshi Isoda, Yoshifusa Abe, Hirokazu Kanegane. Wiskott-Aldrich syndrome with normal-sized platelets. Pediatr Int. 2023.01; 65 (1): e15453. ( PubMed, DOI )

  10. Eguchi Shiori, Isoda Takeshi, Yamaguchi Asuka, Takagi Masatoshi. 出生時に紫斑病を呈したグランツマン血小板無力症の新規変異(Novel variants for Glanzmann thrombasthenia manifesting with purpura at birth) Pediatrics International. 2022.04; 64 (1): 1 of 3-3 of 3. ( ichushi )

  11. Eguchi S, Isoda T, Yamaguchi A, Takagi M. Novel variants for Glanzmann thrombasthenia manifesting with purpura at birth. Pediatr Int. 2022.01; 64 (1): e15149. ( PubMed, DOI )

  12. Tomomasa D, Isoda T, Mitsuiki N, Yamashita M, Morishita A, Tomoda T, Okano T, Endo A, Kamiya T, Yanagimachi M, Imai K, Kanegane H, Takagi M, Morio T. Successful ruxolitinib administration for a patient with steroid-refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review. Clinical case reports. 2021.12; 9 (12): e05242. ( PubMed, DOI )

  13. Nishimura Akira, Aoki Yuki, Ishiwata Yasuyoshi, Ichimura Takuya, Ueyama Junichi, Kawahara Yuta, Tomoda Takahiro, Inoue Maiko, Matsumoto Kazuaki, Inoue Kento, Hiroki Haruka, Ono Shintaro, Yamashita Motoi, Okano Tsubasa, Tanaka-Kubota Mari, Ashiarai Miho, Miyamoto Satoshi, Miyawaki Reiji, Yamagishi Chika, Tezuka Mari, Okawa Teppei, Hoshino Akihiro, Endo Akifumi, Yasuhara Masato, Kamiya Takahiro, Mitsuiki Noriko, Ono Toshiaki, Isoda Takeshi, Yanagimachi Masakatsu, Tomizawa Daisuke, Nagasawa Masayuki, Mizutani Shuki, Kajiwara Michiko, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Hematopoietic Cell Transplantation with Reduced Intensity Conditioning Using Fludarabine/Busulfan or Fludarabine/Melphalan for Primary Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2021.07; 41 (5): 944-957. ( PubMed, DOI )

  14. Endo Akifumi, Yamashita Motoi, Kamiya Takahiro, Mitsuiki Noriko, Isoda Takeshi, Imai Kohsuke, Takagi Masatoshi, Kajiwara Michiko, Kanegane Hirokazu, Morio Tomohiro. A Retrospective Study of Six Cases of HLA Haplo-Identical Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide PEDIATRIC BLOOD & CANCER. 2020.12; 67

  15. Tomomasa Dan, Isoda Takeshi, Yamashita Motoi, Morishita Aoi, Mitsuiki Noriko, Kamiya Takahiro, Imai Kohsuke, Kanegane Hirokazu, Takagi Masatoshi, Morio Tomohiro. Ruxolitinib Administration for Two Cases with Steroid-Refractory Lung GVHD PEDIATRIC BLOOD & CANCER. 2020.12; 67

  16. Isoda Takeshi, Nishimura Akira, Morio Tomohiro, Takagi Masatoshi. Non-Coding RNA ThymoD Transcription Specifies T-Cell Fate and Inhibits T-Cell Malignancies PEDIATRIC BLOOD & CANCER. 2020.12; 67

  17. Inoue Maiko, Isoda Takeshi, Yamashita Motoi, Tomoda Takahiro, Inoue Kento, Okano Tsubasa, Ohkawa Teppei, Endo Akifumi, Mitsuiki Noriko, Kamiya Takahiro, Yanagimachi Masakatsu, Yamamoto Kouhei, Inaba Yuichiro, Sasaki Toru, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Cytomegalovirus Laryngitis in Primary Combined Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2020.10; 41 (1): 243-247. ( PubMed, DOI )

  18. Miyaoka Futaba, Toyofuku Etsushi, Isoda Takeshi, Moiro Tomohiro, Kanegane Hirokazu. Influenza-induced hemolytic crisis in glucose-6-phosphate dehydrogenase deficiency PEDIATRICS INTERNATIONAL. 2020.08; 62 (8): 1003-1004. ( PubMed, DOI )

  19. Miyaoka Futaba, Toyofuku Etsushi, Isoda Takeshi, Moiro Tomohiro, Kanegane Hirokazu. グルコース-6-リン酸脱水素酵素欠乏症の症例で生じたインフルエンザ誘発性の溶血クリーゼ(Influenza-induced hemolytic crisis in glucose-6-phosphate dehydrogenase deficiency) Pediatrics International. 2020.08; 62 (8): 1003-1004. ( ichushi )

  20. Denholtz Matthew, Zhu Yina, He Zhaoren, Lu Hanbin, Isoda Takeshi, Dohrmann Simon, Nizet Victor, Murre Cornelis. Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program GENES & DEVELOPMENT. 2020.02; 34 (3-4): 149-165. ( PubMed, DOI )

  21. Tomoda Takahiro, Nishimura Akira, Ono Rintaro, Isoda Takeshi, Inoue Maiko, Kamiya Takahiro, Yanagimachi Masakatsu, Imai Kohsuke, Kanegane Hirokazu, Hasegawa Daisuke, Morio Tomohiro, Manabe Atsushi, Takagi Masatoshi. Clonal Evolution of Leukemia With MLL-AF9 from Myeloid to T-Lineage PEDIATRIC BLOOD & CANCER. 2019.12; 66 S111.

  22. Hatano Maho, Tomoda Takahiro, Okano Tsubasa, Nunoda Issei, Morishita Aoi, Inoue Kent, Yamashita Motoi, Endo Akifumi, Kamiya Takahiro, Isoda Takeshi, Yanagimachi Masakatsu, Takagi Masatoshi, Kanegane Hirokazu, Okuno Keisuke, Imai Kohsuke, Morio Tomohiro. Intrinsically Vancomycin Resistant Enterococcal (Enterococcus Gallinarum) Meningitis Occurred Early After Hematopoietic Stem Cell Transplantation for Activated PI3K Delta Syndrome Type 2 PEDIATRIC BLOOD & CANCER. 2019.12; 66 S124.

  23. Nunoda Issei, Tomoda Takahiro, Kamiya Takahiro, Okano Tsubasa, Hatano Maho, Yoshimoto Yuri, Muramatsu Hideki, Morishita Aoi, Inoue Kento, Yamashita Motoi, Endo Akifumi, Yanagimachi Masakatsu, Isoda Takeshi, Kanegane Hirokazu, Takagi Masatoshi, Imai Kohsuke, Morio Tomohiro. Efficacy of Azacitidine for MDS Due to Germline GATA2 Haploinsufficiency PEDIATRIC BLOOD & CANCER. 2019.12; 66 S45.

  24. Isoda Takeshi, Morio Tomohiro, Takagi Masatoshi. Noncoding RNA transcription at enhancers and genome folding in cancer CANCER SCIENCE. 2019.08; 110 (8): 2328-2336. ( PubMed, DOI )

  25. Isoda Takeshi, Morio Tomohiro, Takagi Masatoshi. がんのエンハンサー部位で生じるノンコーディングRNAの転写現象とゲノムの折りたたみ(Noncoding RNA transcription at enhancers and genome folding in cancer) Cancer Science. 2019.08; 110 (8): 2328-2336. ( ichushi )

  26. Nishimura Akira, Aoki Yuki, Ishiwata Yasuyoshi, Inoue Maiko, Ichimura Takuya, Ueyama Junichi, Matsumoto Kazuaki, Inoue Kento, Hiroki Haruka, Ono Shintaro, Okano Tsubasa, Tanaka Mari, Miyamoto Satoshi, Ashiarai Miho, Miyawaki Reiji, Yamagishi Chika, Tezuka Mari, Okawa Teppei, Hoshino Akihiro, Endo Akifumi, Yasuhara Masato, Kamiya Takahiro, Mitsuiki Noriko, Ono Toshiaki, Yanagimachi Masakatsu, Isoda Takeshi, Tomizawa Daisuke, Nagasawa Masayuki, Kajiwara Michiko, Takagi Masatoshi, Mizutani Shuki, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Hematopoietic cell transplantation with reduced intensity conditioning regimen using fludarabine/busulfan and fludarabine/melphalan for primary immunodeficiency diseases BONE MARROW TRANSPLANTATION. 2019.07; 54 390-391.

  27. Kubota-Tanaka Mari, Osumi Tomoo, Miura Shouko, Tsujimoto Hiroshi, Imamura Toshihiko, Nishimura Akira, Oki Kentaro, Nakamura Kozue, Miyamoto Satoshi, Inoue Kento, Inoue Maiko, Kamiya Takahiro, Yanagimachi Masakatsu, Okano Tsubasa, Mitsuiki Noriko, Isoda Takeshi, Imai Kohsuke, Kanegane Hirokazu, Morio Tomohiro, Kounami Shinji, Endo Mikiya, Kato Motohiro, Takagi Masatoshi. B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene HAEMATOLOGICA. 2019.01; 104 (1): E35-E37. ( PubMed, DOI )

  28. Fukuda Atsuna, Isoda Takeshi, Sakamoto Naoya, Nakajima Keisuke, Ohta Tetsuya. Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review BMC PEDIATRICS. 2019.01; 19 (1): 39. ( PubMed, DOI )

  29. Isoda Takeshi, Takagi Masatoshi. Non-coding RNA transcription modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies. CANCER SCIENCE. 2018.12; 109 346.

  30. Isoda T, Nishimura A, Miyamoto S, Morio T, Takagi M, Murre C. Non-Coding RNA ThymoD Transcription Modulates Nuclear Architecture to Orchestrate T-Cell Fate and Block T-Cell Malignancies. PEDIATRIC BLOOD & CANCER. 2018.11; 65 S4.

  31. Nagasawa Masayuki, Mitsuiki Noriko, Aoki Yuki, Ono Toshiaki, Isoda Takeshi, Imai Kohsuke, Takagi Masatoshi, Kajiwara Michiko, Kanegane Hirokazu, Morio Tomohiro. Effect of reduced-intensity conditioning and the risk of late-onset non-infectious pulmonary complications in pediatric patients EUROPEAN JOURNAL OF HAEMATOLOGY. 2017.12; 99 (6): 525-531. ( PubMed, DOI )

  32. Dekker J, Belmont AS, Guttman M, Leshyk VO, Lis JT, Lomvardas S, Mirny LA, O'Shea CC, Park PJ, Ren B,Politz JCR, Shendure J, Zhong S, 4D Nucleome Network(…Sasaki T, Isoda T, Misteli T…). The 4D nucleome project Nature. 2017.09; 549 (7671): 219-226.

  33. Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017.09; 171 (1): 103-119.e18. ( PubMed, DOI )

  34. Benner C, Isoda T, Murre C. New roles for DNA cytosine modification, eRNA, anchors, and superanchors in developing B cell progenitors. Proceedings of the National Academy of Sciences of the United States of America. 2015.10; 112 (41): 12776-81. ( PubMed, DOI )

  35. Nakatani K., Imai K., Shigeno M., Sato H., Tezuka M., Okawa T., Mitsuiki N., Isoda T., Tomizawa D., Takagi M., Nagasawa M., Kajiwara M., Yamamoto M., Arai A., Miura O., Kamae C., Nakagawa N., Honma K., Nonoyama S., Mizutani S., Morio T.. Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation BONE MARROW TRANSPLANTATION. 2014.09; 49 (9): 1155-1161. ( PubMed, DOI )

  36. Nagasawa Masayuki, Ohkawa Teppei, Endo Akifumi, Mitsuiki Noriko, Ono Toshiaki, Aoki Yuki, Isoda Takeshi, Tomizawa Daisuke, Takagi Masatoshi, Kajiwara Michiko, Morio Tomohiro, Mizutani Shuki. Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience INTERNATIONAL JOURNAL OF HEMATOLOGY. 2013.11; 98 (5): 533-542. ( PubMed, DOI )

  37. Nagasawa Masayuki, Ohkawa Teppei, Endo Akifumi, Mitsuiki Noriko, Ono Toshiaki, Aoki Yuki, Isoda Takeshi, Tomizawa Daisuke, Takagi Masatoshi, Kajiwara Michiko, Morio Tomohiro, Mizutani Shuki. 同種幹細胞移植後の初期血液凝固異常は移植関連死亡率の強力な予後因子であり、組換えヒトトロンボモジュリンによる介入は予後を改善する 単一施設での経験(Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience) International Journal of Hematology. 2013.11; 98 (5): 533-542. ( ichushi )

  38. Takagi Masatoshi, Sato Masaki, Piao Jinhua, Miyamoto Satoshi, Isoda Takeshi, Kitagawa Masanobu, Honda Hiroaki, Mizutani Shuki. ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia DNA REPAIR. 2013.07; 12 (7): 500-507. ( PubMed, DOI )

  39. Isoda Takeshi, Mitsuiki Noriko, Ohkawa Teppei, Kaneko Setsuko, Endo Akifumi, Ono Toshiaki, Aoki Yuki, Tomizawa Daisuke, Kajiwara Michiko, Araki Satoshi, Nagasawa Masayuki, Morio Tomohiro, Takagi Masatoshi, Mizutani Shuki. Irreversible Leukoencephalopathy After Reduced-intensity Stem Cell Transplantation in a Dyskeratosis Congenita Patient With TINF2 Mutation JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2013.05; 35 (4): E178-E182. ( PubMed, DOI )

  40. Isoda T., Takagi M., Morio T., Kawamoto H., Mizutani S.. VISUALIZATION OF CHROMOSOMAL TRANSLOCATION AND EARLY T-CELL DEVELOPMENT FAILURE IN ATM DEFICIENCY JOURNAL OF CLINICAL IMMUNOLOGY. 2012.09; 32 14-15.

  41. Isoda T., Takagi M., Piao J., Nakagama S., Sato M., Masuda K., Ikawa T., Morio T., Kawamoto H., Mizutani S.. IMMUNE DEFECT AND VISUALIZATION OF CHROMOSOME 14 BREAKS AND TRANSLOCATIONS INVOLVING TCR A/D LOCI DURING EARLY T-CELL DEVELOPMENT LACKING ATM HAEMATOLOGICA. 2012.07; 97 41.

  42. Isoda Takeshi, Takagi Masatoshi, Piao Jinhua, Nakagama Shun, Sato Masaki, Masuda Kyoko, Ikawa Tomokatsu, Azuma Miyuki, Morio Tomohiro, Kawamoto Hiroshi, Mizutani Shuki. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM BLOOD. 2012.07; 120 (4): 789-799. ( PubMed, DOI )

  43. Isoda Takeshi, Takagi Masatoshi, Piao Jinhua, Nakagama Shun, Sato Masaki, Masuda Kyoko, Ikawa Tomokatsu, Azuma Miyuki, Morio Tomohiro, Kawamoto Hiroshi, Mizutani Shuki. T-Cell Development Failure At beta-Selection Checkpoint and TCR alpha/delta Locus Break Formation Associated with Chromosome 14 Translocation in Ataxia-Telangiectagia Mutated Deficient Mice BLOOD. 2011.11; 118 (21): 88-89.

  44. Isoda Takeshi, Ford Anthony, Tomizawa Daisuke, van Delft Frederik W., de Castro David Gonzalez, Mitsuiki Noriko, Score Joannah, Taki Tomohiko, Morio Tomohiro, Takagi Masatoshi, Saji Hiroh, Mizutani Shuki, Greaves Mel. Loss of Non-Inherited Maternal MHC and Materno-Fetal Transmission of p190 Type BCR-ABL Leukemia BLOOD. 2009.11; 114 (22): 407.

  45. Isoda Takeshi, Ford Anthony M., Tomizawa Daisuke, van Delft Frederik W., de Castro David Gonzalez, Mitsuiki Norkio, Score Joannah, Taki Tomohiko, Morio Tomohiro, Takagi Masatoshi, Saji Hiroh, Greaves Mel, Mizutani Shuki. Immunologically silent cancer clone transmission from mother to offspring PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009.10; 106 (42): 17882-17885. ( PubMed, DOI )

  46. Isoda Takeshi, Ito Sukeyuki, Kajiwara Michiko, Nagasawa Masayuki. Successful high-dose methotrexate chemotherapy in a patient with acute lymphocytic leukemia who developed acute renal failure during the initial treatment PEDIATRICS INTERNATIONAL. 2007.12; 49 (6): 1018-1019. ( PubMed, DOI )

  47. Nagasawa Masayuki, Isoda Takeshi, Itoh Sukeyuki, Kajiwara Michiko, Morio Tomohiro, Shimizu Norio, Ogawa Kazuyuki, Nagata Kinya, Nakamura Masataka, Mizutani Shuki. Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: Its usefulness as a marker of graft-versus-host reaction AMERICAN JOURNAL OF HEMATOLOGY. 2006.05; 81 (5): 340-348. ( PubMed, DOI )

  48. Tsuji Y, Imai K, Kajiwara M, Aoki Y, Isoda T, Tomizawa D, Imai M, Ito S, Maeda H, Minegishi Y, Ohkawa H, Yata J, Sasaki N, Kogawa K, Nagasawa M, Morio T, Nonoyama S, Mizutani S. Hematopoietic stem cell transplantation for 30 patients with primary immunodeficiency diseases: 20 years experience of a single team BONE MARROW TRANSPLANTATION. 2006.03; 37 (5): 469-477. ( PubMed, DOI )

  49. Tsuji Y, Ito S, Isoda T, Kajiwara M, Nagasawa M, Morio T, Mizutani S. Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2005.09; 27 (9): 495-498.

  50. Tsuji Y, Ito S, Isoda T, Kajiwara M, Nagasawa M, Morio T, Mizutani S. Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis. Journal of pediatric hematology/oncology. 2005.09; 27 (9): 495-8. ( PubMed, DOI )

  51. Nagasawa M, Zhu Y, Isoda T, Tomizawa D, Itoh S, Kajiwara M, Morio T, Nonoyama S, Shimizu N, Mizutani S. Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L EUROPEAN JOURNAL OF HAEMATOLOGY. 2005.01; 74 (1): 54-60.

  52. Nagasawa M, Zhu Y, Isoda T, Tomizawa D, Itoh S, Kajiwara M, Morio T, Nonoyama S, Shimizu N, Mizutani S. Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L. European journal of haematology. 2005.01; 74 (1): 54-60. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Masatoshi Takagi, Motoi Yamashita, Takahiro Tomoda, Takeshi Isoda, Makiko Egawa, Masayuki Yoshida, Tsutomu Toki, Ko Kudou, Kiminori Terui, Etsuro Ito, Tomohiro Morio. Transient erythroblastopenia by GATA1 variant in female. . Human Genetics Asia 2023 2023.10.14 Tokyo

  2. 西村聡, 佐々木麻起子, 高木正稔, 磯田健志. 非コードRNA転写とスーパーエンハンサー活性化によるゲノムの3次元構造維持機構. 第81回日本癌学会学術総会 2022.09.29 神奈川

  3. 西村 聡, 佐々木 麻起子, 高木 正稔, 磯田 健志. 非コードRNA転写とスーパーエンハンサー活性化によるゲノムの3次元構造維持機構(Non-coding RNA transcription and super-enhancer activation facilitate 3D genome structure). 日本癌学会総会記事 2022.09.01

  4. Dan Tomomasa, Mitsuki Noriko, Isoda Takeshi, Nishimura Akira, Endo Akifumi, Takagi Masatoshi, Kajiwara Michiko, Imai Kohsuke, Morio Tomohiro, Kanegane Hirokazu. Artemis欠損症に対するTCRαβCD19除去移植(Successful TCRABCD19-depleted hematopoietic cell transplantation for a patient with Artemis deficiency). 日本小児血液・がん学会雑誌 2021.10.01

  5. Isoda Takeshi, Nishimura Akira, Morio Tomohiro, Takagi Masatoshi. 血液基礎・核ダイナミクスからnon-coding RNAによる細胞制御 非コードRNA転写による核内局在転換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に関与する(Non-coding RNA ThymoD transcription specifies T-cell fate and inhibits T-cell malignancies). 日本小児血液・がん学会雑誌 2020.10.01

  6. Endo Akifumi, Yamashita Motoi, Kamiya Takahiro, Mitsuiki Noriko, Isoda Takeshi, Imai Kohsuke, Takagi Masatoshi, Kajiwara Michiko, Kanegane Hirokazu, Morio Tomohiro. PTCyハプロ移植症例の6例の後方視的検討(A retrospective study of six cases of HLA haplo-identical hematopoietic stem cell transplantation with Post-Transplant Cyclophosphamide). 日本小児血液・がん学会雑誌 2020.10.01

  7. Tomomasa Dan, Isoda Takeshi, Yamashita Motoi, Morishita Aoi, Mitsuiki Noriko, Kamiya Takahiro, Imai Kohsuke, Kanegane Hirokazu, Takagi Masatoshi, Morio Tomohiro. ステロイド抵抗性肺GVHDに対してルキソリチニブを使用した2例(Ruxolitinib administration for two cases with steroid-refractory lung GVHD). 日本小児血液・がん学会雑誌 2020.10.01

  8. Miyaoka Futaba, Toyofuku Etsushi, Isoda Takeshi, Moiro Tomohiro, Kanegane Hirokazu. Influenza-induced hemolytic crisis in glucose-6-phosphate dehydrogenase deficiency(和訳中). Pediatrics International 2020.08.01

  9. Hatano Maho, Tomoda Takahiro, Okano Tsubasa, Nunoda Issei, Morishita Aoi, Inoue Kento, Yamashita Motoi, Endo Akifumi, Kamiya Takahiro, Isoda Takeshi, Yanagimachi Masakatsu, Takagi Masatoshi, Kanegane Hirokazu, Okuno Keisuke, Imai Kohsuke, Morio Tomohiro. 非血縁者間骨髄移植後早期にバンコマイシン自然耐性腸球菌性髄膜炎に罹患した活性型PI3Kδ症候群2型の1例(Intrinsically Vancomycin resistant enterococcal(Enterococcus gallinarum) meningitis occurred early after hematopoietic stem cell transplantation for activated PI3K delta syndrome type2). 日本小児血液・がん学会雑誌 2019.10.01

  10. Nunoda Issei, Tomoda Takahiro, Kamiya Takahiro, Okano Tsubasa, Hatano Maho, Yoshimoto Yuri, Muramatsu Hideki, Morishita Aoi, Inoue Kento, Yamashita Motoi, Endo Akifumi, Yanagimachi Masakatsu, Isoda Takeshi, Kanegane Hirokazu, Takagi Masatoshi, Imai Kohsuke, Morio Tomohiro. GATA2異常症に伴うMDSに対するAzacitidineの有効性(Efficacy of Azacitidine for MDS due to germline GATA2 haploinsufficiency). 日本小児血液・がん学会雑誌 2019.10.01

  11. Tomoda Takahiro, Nishimura Akira, Ono Rintaro, Isoda Takeshi, Inoue Maiko, Kamiya Takahiro, Yanagimachi Masakatsu, Imai Kohsuke, Kanegane Hirokazu, Hasegawa Daisuke, Morio Tomohiro, Manabe Atsushi, Takagi Masatoshi. 急性骨髄性白血病からT細胞型急性リンパ性白血病へclonal evolutionを起こしたMLL-AF9陽性乳児白血病の一例(Clonal evolution of leukemia with MLL-AF9 from myeloid to T-lineage). 日本小児血液・がん学会雑誌 2019.10.01

  12. Nishimura Akira, Aoki Yuki, Ishiwata Yasuyoshi, Inoue Maiko, Ichimura Takuya, Ueyama Junichi, Matsumoto Kazuaki, Inoue Kento, Hiroki Haruka, Ono Shintaro, Okano Tsubasa, Tanaka Mari, Miyamoto Satoshi, Ashiarai Miho, Miyawaki Reiji, Yamagishi Chika, Tezuka Mari, Okawa Teppei, Hoshino Akihiro, Endo Akifumi, Yasuhara Masato, Kamiya Takahiro, Mitsuiki Noriko, Ono Toshiaki, Yanagimachi Masakatsu, Isoda Takeshi, Tomizawa Daisuke, Nagasawa Masayuki, Kajiwara Michiko, Takagi Masatoshi, Mizutani Shuki, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Hematopoietic cell transplantation with reduced intensity conditioning regimen using fludarabine/busulfan and fludarabine/melphalan for primary immunodeficiency diseases . The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation 2019.03.24 Frankfurt

  13. Isoda Takeshi, Murre Cornelis. 免疫応答のエピジェネティック調節 非コードRNA ThymoD転写は、T細胞の運命を特定し、T細胞悪性疾患を抑制するために核構造を修飾する(Epigenetic regulation of immune response Non-coding RNA ThymoD transcription modulates nuclear architecture to specify T-cell fate and inhibits T-cell malignancies). 日本免疫学会総会・学術集会記録 2018.12.01

  14. Isoda T, Nishimura A, Miyamoto S, Morio T, Takagi M, Murre C. Non-Coding RNA thymod transcription modulates nuclear architecture to Orchestratet-Cell fate and block T-Cell malignancies. SIOP2018 2018.11.17 Kyoto

  15. Inoue Maiko, Isoda Takeshi, Matsumoto Kazuaki, Inoue Kento, Kamiya Takahiro, Yanagimachi Masakatsu, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. 原発性複合免疫不全症におけるサイトメガロウイルス喉頭炎(Cytomegalovirus laryngitis in primary combined immunodeficiency diseases). 日本小児感染症学会総会・学術集会プログラム・抄録集 2018.11.01

  16. Inoue Maiko, Isoda Takeshi, Matsumoto Kazuaki, Inoue Kento, Kamiya Takahiro, Yanagimachi Masakatsu, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. 原発性複合免疫不全症におけるサイトメガロウイルス喉頭炎(Cytomegalovirus laryngitis in primary combined immunodeficiency diseases). 日本小児感染症学会総会・学術集会プログラム・抄録集 2018.11.01

  17. Inoue Maiko, Isoda Takeshi, Matsumoto Kazuaki, Inoue Kento, Kamiya Takahiro, Yanagimachi Masakatsu, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. 原発性複合免疫不全症におけるサイトメガロウイルス喉頭炎(Cytomegalovirus laryngitis in primary combined immunodeficiency diseases). 日本小児感染症学会総会・学術集会プログラム・抄録集 2018.11.01

  18. 磯田 健志, 西村 聡, 宮本 智史, 森尾 友宏, 高木 正稔, ミュア・コーネリウス . 非コードRNA転写による核内構造変換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に寄与する(ThymoD modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies). 臨床血液 2018.09.01

  19. 磯田 健志, 高木 正稔. エピゲノム異常とトランスレーショナルリサーチ 非コードRNA転写による核内構造変換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に寄与する(Epigenome abnormalities and translational research Non-coding RNA transcription modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies). 日本癌学会総会記事 2018.09.01

  20. 磯田 健志, 高木 正稔. エピゲノム異常とトランスレーショナルリサーチ 非コードRNA転写による核内構造変換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に寄与する(Epigenome abnormalities and translational research Non-coding RNA transcription modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies). 日本癌学会総会記事 2018.09.01

  21. 磯田 健志, 高木 正稔. エピゲノム異常とトランスレーショナルリサーチ 非コードRNA転写による核内構造変換はT細胞への系列決定を誘導しT細胞系腫瘍の抑制に寄与する(Epigenome abnormalities and translational research Non-coding RNA transcription modulates nuclear architecture to specify T-cell fate and blocks T-cell malignancies). 日本癌学会総会記事 2018.09.01

  22. Miyamoto Satoshi, Okawa Teppei, Mitsuiki Noriko, Isoda Takeshi, Aoki Yuki, Takagi Masatoshi, Kajiwara Michiko, Imai Kohsuke, Kanegane Hirokazu, Nagasawa Masayuki, Morio Tomohiro. 先天性角化不全症に対する非血縁同種骨髄移植 2症例報告(Unrelated allogenic bone marrow transplantation for dyskeratosis congenita: two case reports). 臨床血液 2015.09.01

  23. Nagasawa Masayuki, Ookawa Teppei, Endo Akifumi, Mitsuiki Noriko, Ono Toshiaki, Aoki Yuki, Isoda Takeshi, Tomizawa Daisuke, Imai Kohsuke, Takagi Masatoshi, Kajiwara Michiko, Morio Tomohiro, Mizutani Shuki. トロンボモジュリン-αは同種異系SCT後の凝固不全を伴うTRMを改善する(Thrombomodulin-alpha improves the coagulation disorder associated TRM after allogeneic SCT). 臨床血液 2012.09.01

  24. 磯田 健志, 高木 正稔, 森尾 友宏, 水谷 修紀. ATM欠損早期T細胞分化における14番染色体TCRd鎖切断と転座形成の可視化(Visualization of chromosome 14 breaks and translocations involving TCRd loci during early T-cell development lacking ATM). 日本癌学会総会記事 2012.08.01

  25. 磯田 健志, 高木 正稔, 森尾 友宏, 水谷 修紀. ATM欠損早期T細胞分化における14番染色体TCRd鎖切断と転座形成の可視化(Visualization of chromosome 14 breaks and translocations involving TCRd loci during early T-cell development lacking ATM). 日本癌学会総会記事 2012.08.01

  26. 磯田 健志, 高木 正稔, 森尾 友宏, 水谷 修紀. ATM欠損早期T細胞分化における14番染色体TCRd鎖切断と転座形成の可視化(Visualization of chromosome 14 breaks and translocations involving TCRd loci during early T-cell development lacking ATM). 日本癌学会総会記事 2012.08.01

  27. Nagasawa Masayuki, Okawa Teppei, Endo Akifumi, Mitsuiki Noriko, Aoki Yuki, Ono Toshiaki, Isoda Takeshi, Tomizawa Daisuke, Takagi Masatoshi, Morio Tomohiro, Mizutani Shuki, Kajiwara Michiko, Ishiwata Yasuyoshi, Yasuhara Masato. SCT施行小児患者におけるbusulfan経口投与および静脈内投与の後向きPK/PD解析(Retrospective PK/PD analysis of oral and intravenous busulfan in pediatric patients having SCT). 臨床血液 2011.09.01

  28. 高木 正稔, 烏野 初萌, 磯田 健志, 杉本 昌隆, 安田 章夫, 水谷 修紀. DNA損傷応答と細胞代謝におけるATMファミリー蛋白質の新側面 ATMは細胞分化を制御する(Novel Aspect of ATM family proteins in DNA damage responses and cellular metabolism ATM regulates cell differentiation). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2010.12.01

  29. Isoda Takeshi. 免疫学的に無症候性癌クローンの母から子に対する伝達(Immunologically silent cancer clone transmission from mother to offspring). 小児がん 2010.12.01

  30. Isoda Takeshi, Mitsuiki Noriko, Aoki Yuki, Tomizawa Daisuke, Takagi Masatoshi, Nagasawa Masayuki, Morio Tomohiro, Ochiai Nakaba, Taki Tomohiko, Taniwaki Masafumi, Saji Hiroh, Mizutani Shuki. p190型BCR-ABL白血病の母児移行の原因としてのNIMAの欠失(Loss of NIMA as a possible role of materno-fetal transmission of p190 type BCR-ABL leukemia). 臨床血液 2009.09.01

  31. 磯田 健志, 高木 正稔, 長澤 正之, 森尾 友宏, 滝 智彦, 谷脇 雅史, 水谷 修紀. p190型BCR-ABL白血病における母児間転移と非遺伝母HLAアレル(NIMA)欠損(Materno-fetal transmission and loss of non-inherited maternal MHC in p190 type BCR-ABL leukemia). 日本癌学会総会記事 2009.08.01

  32. 磯田 健志, 高木 正稔, 長澤 正之, 森尾 友宏, 滝 智彦, 谷脇 雅史, 水谷 修紀. p190型BCR-ABL白血病における母児間転移と非遺伝母HLAアレル(NIMA)欠損(Materno-fetal transmission and loss of non-inherited maternal MHC in p190 type BCR-ABL leukemia). 日本癌学会総会記事 2009.08.01

  33. 磯田 健志, 高木 正稔, 長澤 正之, 森尾 友宏, 滝 智彦, 谷脇 雅史, 水谷 修紀. p190型BCR-ABL白血病における母児間転移と非遺伝母HLAアレル(NIMA)欠損(Materno-fetal transmission and loss of non-inherited maternal MHC in p190 type BCR-ABL leukemia). 日本癌学会総会記事 2009.08.01

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