Personnel Information

写真a

MAEJIMA Yasuhiro


Job title

Associate Professor

Birth date

1971

Mail Address

ymaeji.cvm@tmd.ac.jp

Graduating School 【 display / non-display

  • Shinshu University, Faculty of Medicine, 1996.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2005.03, Completed

Campus Career 【 display / non-display

  • 2001.04
    -
    2005.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Graduate Student
  • 2006.04
    -
    2008.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Assistant Professor
  • 2012.10
    -
    2013.07
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Project Assistant Professor
  • 2013.08
    -
    2015.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Assistant Professor
  • 2015.04
    -
    2019.09
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Junior Associate Professor

display all >>

External Career 【 display / non-display

  • 1996.05
    -
    1997.03
    , Trainee Resident
  • 1999.04
    -
    2001.03
    , Resident
  • 2008.04
    -
    2012.05
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Cell Biology and Molecular Medicine, Postdoctoral Fellow
  • 2012.06
    -
    2013.06
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Cell Biology and Molecular Medicine, Assistant Professor
  • 2013.07
    -
    Now
    Rutgers-New Jersey Medical School, Cell Biology and Molecular Medicine, Adjunct Assistant Professor

Academic Society Affiliations 【 display / non-display

  • American Heart Assosiation

Academic Activity 【 display / non-display

  • 2016.07
    -
    Now
    American Heart Association Fellowship of American Heart Association
  • 2016.09
    -
    Now
    European Society of Cardiology Fellowship of European Society of Cardiology
  • 2018.03
    -
    Now
    Japanese Circulation Society Fellowship of Japanese Circulation Society

Research Areas 【 display / non-display

  • Cardiovascular medicine

  • Cell biology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Regulation of cardiac hypertrophy and LV dysfunction in response to pressure overload by GSK- 3beta-FoxO1-mediated signal, 2012.07 - 2016.06

Published Papers & Misc 【 display / non-display

  • Yasuhiro Maejima, Shiori Kyoi, Peiyong Zhai, Tong Liu, Hong Li, Andreas Ivessa, Sebastiano Sciarretta, Dominic P Del Re, Daniela K Zablocki, Chiao-Po Hsu, Dae-Sik Lim, Mitsuaki Isobe, Junichi Sadoshima. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature Medicine. 2013.11; 19 (11): 1478-1488. ( PubMed, DOI )

  • Yasuhiro Maejima, Soichiro Usui, Peiyong Zhai, Masayuki Takamura, Shuichi Kaneko, Daniela Zablocki, Mitsuhiro Yokota, Mitsuaki Isobe, Junichi Sadoshima. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. Circ Heart Fail. 2014.05; 7 (3): 479-490. ( PubMed, DOI )

  • Soichiro Usui, Yasuhiro Maejima, Jayashree Pain, Chull Hong, Jaeyeaon Cho, Ji Yeon Park, Daniela Zablocki, Bin Tian, David J Glass, Junichi Sadoshima. Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ. Res.. 2011.07; 109 (2): 161-171. ( PubMed, DOI )

  • Yasuhiro Maejima, Susumu Adachi, Hiroshi Ito, Kenzo Hirao, Mitsuaki Isobe. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell. 2008.03; 7 (2): 125-136. ( PubMed, DOI )

  • Yasuhiro Maejima, Susumu Adachi, Hiroshi Ito, Kiyoshi Nobori, Mimi Tamamori-Adachi, Mitsuaki Isobe. Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity. Cardiovasc. Res.. 2003.08; 59 (2): 308-320. ( PubMed )

display all >>

Books etc 【 display / non-display

  • Maejima Y, Zablocki D, Sadoshima J. . Muscle 1st Edition: Fundamental Biology and Mechanisms and Disease.. Academic Press, 2012.08 Oxidative stress and cardiac muscle (ISBN : 978-0123815101)

Conference Activities & Talks 【 display / non-display

  • Yasuhiro Maejima. The Critical Role of Single Nucleotide Polymorphism of MLX Gene in the Pathogenesis of Large Vessel Vasculitis by Promoting Brown Adipose Tissue-Mediated Inflammatory Response in Mice. 第85回日本循環器学会学術集会 2021.03.27 神奈川県横浜市

  • Yasuhiro Maejima. Impairment of the Protein Quality Control Systems Leads to the Pathogenesis of Heart Failure. 第85回日本循環器学会学術集会 2021.03.27 神奈川県横浜市

  • Yasuhiro Maejima. Chemical Proteomics-Guided Identification of a Novel Target of Empagliflozin, a SGLT2 inhibitor. Seminar at RNJMS-CBMM 2019.11.19 Newark, NJ, USA

  • Yasuhiro Maejima. Empagliflozin, a SGLT2 Inhibitor, Directly Protects Cardiomyocytes by off-target Effect-mediated Promotion of Mitophagy. American Heart Association Scientific Sessions 2019 2019.11.18 Philadelphia, PA, USA

  • Yasuhiro Maejima. Factor Xa Exacerbates Atherosclerosis by Promoting Inflammasome Formation through PAR2-mediated Autophagy Suppression. The 3rd JCS Council Forum on Basic Cardiovascular Research 2019.09.06 東京都中央区

display all >>

Awards & Honors 【 display / non-display

  • Star Reviewer 2017, American Physiological Society,American Physiological Society,2018.11

  • Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences,American Heart Association,2012.11

  • Louis N. and Arnold M. Katz Basic Research Prize,American Heart Association,2011.11

  • BCVS Abstract Travel Award 2010,American Heart Association,2010.11

  • BCVS Abstract Travel Award 2009,American Heart Association,2009.11

display all >>

 

Performance of duties 【 display / non-display

  • ,2015.07 - Now

  • ,2014.04 - Now

  • ,2014.04 - 2015.03

  • ,2013.08 - Now

  • ,2012.10 - 2013.07

display all >>