Personnel Information

写真a

MAEJIMA Yasuhiro


Job title

Associate Professor

Birth date

1971

Mail Address

ymaeji.cvm@tmd.ac.jp

Graduating School 【 display / non-display

  • Shinshu University, Faculty of Medicine, 1996.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2005.03, Completed

Campus Career 【 display / non-display

  • 2001.04
    -
    2005.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Graduate Student
  • 2006.04
    -
    2008.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Assistant Professor
  • 2012.10
    -
    2013.07
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Project Assistant Professor
  • 2013.08
    -
    2015.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Assistant Professor
  • 2015.04
    -
    2019.09
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Cardiovascular Medicine, Junior Associate Professor
  • 2019.10
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Cardiovascular Medicine, Associate Professor

▼display all

External Career 【 display / non-display

  • 1996.05
    -
    1997.03
    , Trainee Resident
  • 1999.04
    -
    2001.03
    , Resident
  • 2008.04
    -
    2012.05
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Cell Biology and Molecular Medicine, Postdoctoral Fellow
  • 2012.06
    -
    2013.06
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Cell Biology and Molecular Medicine, Assistant Professor
  • 2013.07
    -
    Now
    Rutgers-New Jersey Medical School, Cell Biology and Molecular Medicine, Adjunct Assistant Professor

Academic Society Affiliations 【 display / non-display

  • American Heart Assosiation

Academic Activity 【 display / non-display

  • 2016.07
    -
    Now
    American Heart Association Fellowship of American Heart Association
  • 2016.09
    -
    Now
    European Society of Cardiology Fellowship of European Society of Cardiology
  • 2018.03
    -
    Now
    Japanese Circulation Society Fellowship of Japanese Circulation Society

Research Areas 【 display / non-display

  • Cardiology

  • Cell biology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Regulation of cardiac hypertrophy and LV dysfunction in response to pressure overload by GSK- 3beta-FoxO1-mediated signal, 2012.07 - 2016.06

Published Papers & Misc 【 display / non-display

  1. Yasuhiro Maejima, Shiori Kyoi, Peiyong Zhai, Tong Liu, Hong Li, Andreas Ivessa, Sebastiano Sciarretta, Dominic P Del Re, Daniela K Zablocki, Chiao-Po Hsu, Dae-Sik Lim, Mitsuaki Isobe, Junichi Sadoshima. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature Medicine. 2013.11; 19 (11): 1478-1488. ( PubMed, DOI )

  2. Yasuhiro Maejima, Soichiro Usui, Peiyong Zhai, Masayuki Takamura, Shuichi Kaneko, Daniela Zablocki, Mitsuhiro Yokota, Mitsuaki Isobe, Junichi Sadoshima. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. Circ Heart Fail. 2014.05; 7 (3): 479-490. ( PubMed, DOI )

  3. Soichiro Usui, Yasuhiro Maejima, Jayashree Pain, Chull Hong, Jaeyeaon Cho, Ji Yeon Park, Daniela Zablocki, Bin Tian, David J Glass, Junichi Sadoshima. Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ. Res.. 2011.07; 109 (2): 161-171. ( PubMed, DOI )

  4. Yasuhiro Maejima, Susumu Adachi, Hiroshi Ito, Kenzo Hirao, Mitsuaki Isobe. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell. 2008.03; 7 (2): 125-136. ( PubMed, DOI )

  5. Yasuhiro Maejima, Susumu Adachi, Hiroshi Ito, Kiyoshi Nobori, Mimi Tamamori-Adachi, Mitsuaki Isobe. Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity. Cardiovasc. Res.. 2003.08; 59 (2): 308-320. ( PubMed )

  6. Masataka Sano, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano. Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy. Front Cell Dev Biol. 2022.07; 10 876147. ( PubMed, DOI )

  7. Taku Fukushima, Taishi Yonetsu, Norio Aoyama, Akira Tashiro, Takayuki Niida, Yuka Shiheido-Watanabe, Yasuhiro Maejima, Mitsuaki Isobe, Takanori Iwata, Tetsuo Sasano. Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers. Circ J. 2022.04; 86 (5): 811-818. ( PubMed, DOI )

  8. Keita Watanabe, Takashi Ashikaga, Yasuhiro Maejima, Susumu Tao, Mao Terui, Tetsuya Kishigami, Masakazu Kaneko, Ryota Nakajima, Shinichiro Okata, Tetsumin Lee, Tomoki Horie, Masashi Nagase, Giichi Nitta, Ryoichi Miyazaki, Sho Nagamine, Yasutoshi Nagata, Toshihiro Nozato, Masahiko Goya, Tetsuo Sasano. Case Report: Importance of MRI Examination in the Diagnosis and Evaluation of COVID-19 mRNA Vaccination Induced Myocarditis: Our Experience and Literature Review. Front Cardiovasc Med. 2022.04; 9 844626. ( PubMed, DOI )

  9. Masanori Asakura, Shin Ito, Takahisa Yamada, Yoshihiko Saito, Kazuo Kimura, Akira Yamashina, Atsushi Hirayama, Youichi Kobayashi, Akihisa Hanatani, Mitsuru Tsujimoto, Satoshi Yasuda, Yukio Abe, Yorihiko Higashino, Yodo Tamaki, Hiroshi Sugino, Hiroyuki Niinuma, Yoshitaka Okuhara, Toshimi Koitabashi, Shin-Ichi Momomura, Kuniya Asai, Akihiro Nomura, Hiroya Kawai, Yasuhiro Satoh, Tsutomu Yoshikawa, Ken-Ichi Hirata, Yoshiaki Yokoi, Jun Tanaka, Yoshisato Shibata, Yasuhiro Maejima, Shunsuke Tamaki, Hiroyuki Kawata, Noriaki Iwahashi, Masatake Kobayashi, Yoshiharu Higuchi, Akiko Kada, Haruko Yamamoto, Masafumi Kitakaze. Efficacy and Safety of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure (EARLIER trial): a multicentre, randomized, double-blind, placebo-controlled trial. Eur Heart J Cardiovasc Pharmacother. 2022.02; 8 (2): 108-117. ( PubMed, DOI )

  10. Yasuhiro Maejima, Daniela Zablocki, Jihoon Nah, Junichi Sadoshima. The role of the Hippo pathway in autophagy in the heart. Cardiovasc Res. 2022.02; ( PubMed, DOI )

  11. Shun Nakagama, Katherine Candray, Tasuku Yamamoto, Yuta Tsugeno, Yu Nakagama, Yasutoshi Kido, Yuko Nitahara, Yasuhiro Maejima, Tetsuo Sasano. Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association. ESC Heart Fail. 2022.02; 9 (1): 761-765. ( PubMed, DOI )

  12. Yusuke Ito, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Tetsuo Sasano. Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa-PAR2-Mediated Autophagy Suppression. JACC Basic Transl Sci. 2021.12; 6 (12): 964-980. ( PubMed, DOI )

  13. Seiya Oba, Tadashi Hosoya, Miki Amamiya, Takahiro Mitsumura, Daisuke Kawata, Hirokazu Sasaki, Mari Kamiya, Akio Yamamoto, Takahiro Ando, Sho Shimada, Tsuyoshi Shirai, Tsukasa Okamoto, Tomoya Tateishi, Akira Endo, Junichi Aiboshi, Nobuyuki Nosaka, Hideo Yamanouchi, Toyomu Ugawa, Eiki Nagaoka, Keiji Oi, Susumu Tao, Yasuhiro Maejima, Yukie Tanaka, Kousuke Tanimoto, Hiroaki Takeuchi, Shuji Tohda, Akihiro Hirakawa, Tetsuo Sasano, Hirokuni Arai, Yasuhiro Otomo, Yasunari Miyazaki, Shinsuke Yasuda. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Front Cardiovasc Med. 2021.11; 8 767074. ( PubMed, DOI )

  14. Takahiko Sugihara, Yoshikazu Nakaoka, Haruhito A Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Yoshiko Watanabe, Eisuke Amiya, Kazuo Tanemoto, Tetsuro Miyata, Natsuka Umezawa, Yusuke Manabe, Jun Ishizaki, Tsuyoshi Shirai, Hiroko Nagafuchi, Hitoshi Hasegawa, Takako Miyamae, Hiroaki Niiro, Shuichi Ito, Tomonori Ishii, Mitsuaki Isobe, Masayoshi Harigai. Establishing Clinical Remission Criteria and the Framework of a Treat-To-Target Algorithm for Takayasu arteritis: Results of a Delphi Exercise Carried out by an Expert Panel of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for intractable vasculitis. Mod Rheumatol. 2021.11; ( PubMed, DOI )

  15. Natsuko Tamura, Yasuhiro Maejima, Yuka Shiheido-Watanabe, Shun Nakagama, Mitsuaki Isobe, Tetsuo Sasano. Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis. Sci Rep. 2021.09; 11 (1): 18958. ( PubMed, DOI )

  16. Yanbin Chen, Yasuhiro Maejima, Akihiro Shirakabe, Takanobu Yamamoto, Yoshiyuki Ikeda, Junichi Sadoshima, Peiyong Zhai. Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy. J Cardiovasc Aging. 2021.08; 1 9. ( PubMed, DOI )

  17. Yuka Shiheido-Watanabe, Yasuhiro Maejima, Takeshi Kasama, Natsuko Tamura, Shun Nakagama, Yusuke Ito, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano. Linagliptin, a Xanthine-based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis. JACC Basic Transl Sci. 2021.06; 6 (6): 527-542. ( PubMed, DOI )

  18. Mitsuaki Isobe, Yasuhiro Maejima, Mike Saji, Ukihide Tateishi. F-fluorodeoxyglucose-positron emission tomography for detecting inflammation under tocilizumab treatment. J Cardiol. 2021.05; 77 (5): 539-544. ( PubMed, DOI )

  19. Masataka Kamiya, Kuniya Asai, Yasuhiro Maejima, Akihiro Shirakabe, Koji Murai, Satsuki Noma, Hidenori Komiyama, Naoki Sato, Kyoichi Mizuno, Wataru Shimizu. Beta3-adrenergic Receptor Agonist Prevents Diastolic Dysfunction in an Angiotensin II-Induced Cardiomyopathy Mouse Model. J Pharmacol Exp Ther. 2021.03; 376 (3): 473-481. ( PubMed, DOI )

  20. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Maejima Y, et al.. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.02; 17 (1): 1-382. ( PubMed, DOI )

  21. Yoshikazu Nakaoka, Mitsuaki Isobe, Yoshiya Tanaka, Tomonori Ishii, Seido Ooka, Hiroaki Niiro, Naoto Tamura, Shogo Banno, Hajime Yoshifuji, Yasushi Sakata, Atsushi Kawakami, Tatsuya Atsumi, Shunsuke Furuta, Hitoshi Kohsaka, Katsuya Suzuki, Ryoki Hara, Yasuhiro Maejima, Hiroshi Tsukamoto, Yoshinari Takasaki, Katsuhisa Yamashita, Norihiro Okada, Shinji Yamakido, Syuji Takei, Shumpei Yokota, Norihiro Nishimoto. Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study. Rheumatology (Oxford). 2020.09; 59 (9): 2427-2434. ( PubMed, DOI )

  22. Tezuka Daisuke, Maejima Yasuhiro, Sasano Tetsuo, Isobe Mitsuaki. Diagnostic Role and Feasibility of 18F-FDG PET for Assessing Takayasu Arteritis: Diagnostic Efficacy of Quantifying 18F-FDG Uptake Annals of Nuclear Cardiology. 2020.08; 6 (1): 74-80. ( ichushi )

  23. Yuji Matsuda, Takashi Ashikaga, Taro Sasaoka, Yu Hatano, Tomoyuki Umemoto, Tetsumin Lee, Taishi Yonetsu, Yasuhiro Maejima, Tetsuo Sasano. Comparison of Neointimal Response between Durable-Polymer Everolimus-Eluting Stent and Bioabsorbable-Polymer Everolimus-Eluting Stent for Severely Calcified Lesions Requiring Rotational Atherectomy. Int Heart J. 2020.07; 61 (4): 665-672. ( PubMed, DOI )

  24. Yuji Matsuda, Takashi Ashikaga, Taro Sasaoka, Yu Hatano, Tomoyuki Umemoto, Tetsumin Lee, Taishi Yonetsu, Yasuhiro Maejima, Tetsuo Sasano. Ostial left circumflex lesion with calcified nodule successfully treated with excimer laser coronary atherectomy and drug-coated balloon. J Cardiol Cases. 2020.07; 22 (1): 32-35. ( PubMed, DOI )

  25. Takahiko Sugihara, Hitoshi Hasegawa, Haruhito A Uchida, Hajime Yoshifuji, Yoshiko Watanabe, Eisuke Amiya, Yasuhiro Maejima, Masanori Konishi, Yohko Murakawa, Noriyoshi Ogawa, Shunsuke Furuta, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka, Tsutomu Takeuchi, Yoshikazu Nakaoka, Yoshihiro Arimura, Masayoshi Harigai, Mitsuaki Isobe, . Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions. Arthritis Res. Ther.. 2020.04; 22 (1): 72. ( PubMed, DOI )

  26. Yasuhiro Maejima. The critical roles of protein quality control systems in the pathogenesis of heart failure. J Cardiol. 2020.03; 75 (3): 219-227. ( PubMed, DOI )

  27. Mitsuaki Isobe, Koichi Amano, Yoshihiro Arimura, Akihiro Ishizu, Shuichi Ito, Shinya Kaname, Shigeto Kobayashi, Yoshinori Komagata, Issei Komuro, Kimihiro Komori, Kei Takahashi, Kazuo Tanemoto, Hitoshi Hasegawa, Masayoshi Harigai, Shouichi Fujimoto, Tatsuhiko Miyazaki, Tetsuro Miyata, Hidehiro Yamada, Akitoshi Yoshida, Takashi Wada, Yoshinori Inoue, Haruhito A Uchida, Hideki Ota, Takahiro Okazaki, Mitsuho Onimaru, Tamihiro Kawakami, Reiko Kinouchi, Atsushi Kurata, Hisanori Kosuge, Ken-Ei Sada, Kunihiro Shigematsu, Eiichi Suematsu, Eijun Sueyoshi, Takahiko Sugihara, Hitoshi Sugiyama, Mitsuhiro Takeno, Naoto Tamura, Michi Tsutsumino, Hiroaki Dobashi, Yoshikazu Nakaoka, Kenji Nagasaka, Yasuhiro Maejima, Hajime Yoshifuji, Yoshiko Watanabe, Shoichi Ozaki, Takeshi Kimura, Hiroshi Shigematsu, Keiko Yamauchi-Takihara, Toyoaki Murohara, Shin-Ichi Momomura, . JCS 2017 Guideline on Management of Vasculitis Syndrome - Digest Version. Circ J. 2020.01; 84 (2): 299-359. ( PubMed, DOI )

  28. Yasuhiro Maejima. SGLT2 Inhibitors Play a Salutary Role in Heart Failure via Modulation of the Mitochondrial Function. Front Cardiovasc Med. 2020.01; 6 186. ( PubMed, DOI )

  29. Shun Nakagama, Taishi Yonetsu, Shinya Shiohira, Yuji Matsuda, Taro Sasaoka, Yu Hatano, Atsuhiko Yagishita, Tomoyuki Umemoto, Shingo Maeda, Takanobu Yamamoto, Tomohiro Yoneyama, Yoshio Kitazume, Yoshihide Takahashi, Yasuhiro Maejima, Mihoko Kawabata, Masahiko Goya, Takashi Ashikaga, Hirokuni Arai, Kenzo Hirao. Exertional syncope caused by myocardial ischemia due to arterial steal syndrome in left internal mammary artery graft. Coron. Artery Dis.. 2019.09; 30 (6): 469-470. ( PubMed, DOI )

  30. Tsutsui Hiroyuki, Momomura Shin-ichi, Masuyama Tohru, Saito Yoshihiko, Komuro Issei, Murohara Toyoaki, Kinugawa Shintaro, Oba Koji, Sato Norihiro, Yasumura Yoshio, Hiramitsu Shinya, Satou Yukihito, Inomata Takayuki, Onishi Katsuya, Sakata Yasushi, Mizuno Kyoichi, Sunagawa Kenji, Ogawa Hisao, Isobe Mitsuaki, Daida Hiroyuki, Kurabayashi Masahiko, Kinugawa Shintaro, Kohya Tetsuro, Ogawa Yuji, Itoh Naofumi, Kakinoki Shigeo, Aoki Kenji, Tsuchida Akihito, Ito Hiroshi, Yamaguchi Osamu, Eki Yutaka, Toyoda Shigeru, Nakano Akihiko, Koitabashi Norimichi, Muramatsu Toshihiro, Nakahara Hideo, Tanaka Hiroyuki, Yamashina Akira, Takasu Kiyoshi, Maejima Yasuhiro, Momiyama Yukihiko, Nakamura Iwao, Kida Keisuke, Naruke Takashi, Takenobu Hideshi, Minamino Tohru, Nakamura Masahiko, Ikeda Masatoshi, Ashida Kazuhiro, Takahashi Shigekiyo, Minatoguchi Shinya, Suwa Satoru, Satoh Hiroshi, Izawa Hideo, Fukuta Hidekatsu, Tsuboi Naoya, Uzui Hiroyasu, Wada Atsuyuki, Kimura Takeshi, Takenaka Ken, Kato Takao, Okutsu Masaaki, Ohtani Tomohito, Hasegawa Shinji, Anzai Toshihisa, Fujii Kenshi, Shiojima Ichiro, Yasaka Yoshinori, Masuyama Tohru, Hirata Ken-ichi, Saito Yoshihiko, Akasaka Takashi, Ito Hiroshi, Kihara Yasuki, Tamura Ritsu, Teragawa Hiroki, Yasuda Kotaro, Okuhara Koichiro, Karashima Eiji, Sata Masataka, Ota Akira, Noma Takahisa, Suzuki Jun, Watanabe Kouki, Kitaoka Hiroaki, Matsukawa Ryuichi, Yoshihiro Takeshi, Tanaka Nobuhide, Ozumi Kiyoshi, Takahashi Masaru, Maemura Koji, Atsuchi Nobuhiko. Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial - CIRCULATION JOURNAL. 2019.06; 83 (6): 1269-+. ( DOI )

  31. Toshiro Saito, Jihoon Nah, Shin-Ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, Junichi Sadoshima. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J. Clin. Invest.. 2019.02; 129 (2): 802-819. ( PubMed, DOI )

  32. Hiroaki Kikuchi, Emi Sasaki, Naohiro Nomura, Takayasu Mori, Yoji Andrew Minamishima, Yuki Yoshizaki, Naohiro Takahashi, Taisuke Furusho, Yohei Arai, Shintaro Mandai, Takahiro Yamashita, Fumiaki Ando, Yasuhiro Maejima, Kiyoshi Isobe, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney Int.. 2019.01; 95 (1): 123-137. ( PubMed, DOI )

  33. Junichi Tsuchiya, Daisuke Tezuka, Yasuhiro Maejima, Hyeyeol Bae, Takumi Oshima, Tomohiro Yoneyama, Kenzo Hirao, Mitsuaki Isobe, Ukihide Tateishi . Takayasu arteritis: clinical importance of extra-vessel uptake on FDG PET/CT European Journal of Hybrid Imaging. 2019; 3 12.

  34. Takanobu Yamamoto, Sawako Yada, Yuji Matsuda, Hirofumi Otani, Shunji Yoshikawa, Taro Sasaoka, Yu Hatano, Tomoyuki Umemoto, Daisuke Ueshima, Yasuhiro Maejima, Kenzo Hirao, Takashi Ashikaga. A Novel Rotablator Technique (Low-Speed following High-Speed Rotational Atherectomy) Can Achieve Larger Lumen Gain: Evaluation Using Optimal Frequency Domain Imaging. J Interv Cardiol. 2019; 2019 9282876. ( PubMed, DOI )

  35. Chikashi Terao, Hajime Yoshifuji, Takayoshi Matsumura, Taeko K Naruse, Tomonori Ishii, Yoshikazu Nakaoka, Yohei Kirino, Keitaro Matsuo, Tomoki Origuchi, Masakazu Shimizu, Yasuhiro Maejima, Eisuke Amiya, Natsuko Tamura, Takahisa Kawaguchi, Meiko Takahashi, Kazuya Setoh, Koichiro Ohmura, Ryu Watanabe, Tetsuya Horita, Tatsuya Atsumi, Mitsuru Matsukura, Tetsuro Miyata, Yuta Kochi, Toshio Suda, Kazuo Tanemoto, Akira Meguro, Yukinori Okada, Akiyoshi Ogimoto, Motohisa Yamamoto, Hiroki Takahashi, Shingo Nakayamada, Kazuyoshi Saito, Masataka Kuwana, Nobuhisa Mizuki, Yasuharu Tabara, Atsuhisa Ueda, Issei Komuro, Akinori Kimura, Mitsuaki Isobe, Tsuneyo Mimori, Fumihiko Matsuda. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis Proc. Natl. Acad. Sci. U.S.A.. 2018.11; ( PubMed, DOI )

  36. Natsuko Tamura, Yasuhiro Maejima, Takayoshi Matsumura, Rick B Vega, Eisuke Amiya, Yusuke Ito, Yuka Shiheido-Watanabe, Takashi Ashikaga, Issei Komuro, Daniel P Kelly, Kenzo Hirao, Mitsuaki Isobe. Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis Circ Genom Precis Med. 2018.10; 11 (10): e002296. ( PubMed, DOI )

  37. Yasuhiro Maejima. Everything in Moderation. Int Heart J. 2018.10; 59 (5): 917-919. ( PubMed, DOI )

  38. Daisuke Ueshima, Shunji Yoshikawa, Taro Sasaoka, Yu Hatano, Ken Kurihara, Yasuhiro Maejima, Mitsuaki Isobe, Takashi Ashikaga. The Hypercholesterolemia Paradox in Percutaneous Coronary Intervention: An Analysis of a Multicenter PCI Registry. Intern. Med.. 2018.09; ( PubMed, DOI )

  39. Yuji Matsuda, Takashi Ashikaga, Taro Sasaoka, Yu Hatano, Tomoyuki Umemoto, Takanobu Yamamoto, Yasuhiro Maejima, Kenzo Hirao. Effectiveness of the proximal optimization technique for longitudinal stent elongation caused by post-balloon dilatation. Journal of Interventional Cardiology. 2018.07; ( PubMed, DOI )

  40. Daisuke Ueshima, Shunji Yoshikawa, Taro Sasaoka, Yu Hatano, Ken Kurihara, Yasuhiro Maejima, Mitsuaki Isobe, Takashi Ashikaga. Obesity paradox in the era of percutaneous coronary intervention with 2nd-generation drug-eluting stents: an analysis of a multicenter PCI registry. Heart Vessels. 2018.07; ( PubMed, DOI )

  41. Yusuke Ito, Yasuhiro Maejima, Natsuko Tamura, Yuka Shiheido-Watanabe, Masanori Konishi, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe. Synergistic effects of HMG-CoA reductase inhibitor and angiotensin II receptor blocker on load-induced heart failure. FEBS Open Bio. 2018.05; 8 (5): 799-816. ( PubMed, DOI )

  42. Sebastiano Sciarretta, Yasuhiro Maejima, Daniela Zablocki, Junichi Sadoshima. The Role of Autophagy in the Heart. Annu. Rev. Physiol.. 2018.02; 80 1-26. ( PubMed, DOI )

  43. Taku Fukushima, Takashi Ashikaga, Shunji Yoshikawa, Yu Hatano, Daisuke Ueshima, Takanobu Yamamoto, Yasuhiro Maejima, Mitsuaki Isobe. Effect of drug-coated balloon on stent restenosis, neointimal proliferation, and coronary dissection: an optical coherence tomography analysis. Coron. Artery Dis.. 2017.09; ( PubMed, DOI )

  44. Natsuko Tamura, Yasuhiro Maejima, Daisuke Tezuka, Chisato Takamura, Shunji Yoshikawa, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe. Profiles of serum cytokine levels in Takayasu arteritis patients: Potential utility as biomarkers for monitoring disease activity. J Cardiol. 2017.09; 70 (3): 278-285. ( PubMed, DOI )

  45. Anindita Das, Flávio Reis, Yasuhiro Maejima, Zhiyou Cai, Jun Ren. mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging. Oxid Med Cell Longev. 2017.07; 2017 6018675. ( PubMed, DOI )

  46. Ueshima Daisuke, Ashikaga Takashi, Yoshikawa Shunji, Sasaoka Taro, Hatano Yu, Kurihara Ken, Maejima Yasuhiro, Isobe Mitsuaki. Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry Journal of Cardiology. 2017.06; 69 (5-6): 815-822. ( ichushi )

  47. Ryo Watanabe, Jun-Ichi Suzuki, Kouji Wakayama, Yasuhiro Maejima, Munehisa Shimamura, Hiroshi Koriyama, Hironori Nakagami, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Ryuichi Morishita, Issei Komuro, Mitsuaki Isobe. A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction. Sci Rep. 2017.03; 7 43920. ( PubMed, DOI )

  48. Maejima Yasuhiro. 心不全におけるオートファジーの決定的役割(The critical role of autophagy in heart failure) Journal of Pharmacological Sciences. 2017.03; 133 (3Suppl.): S52. ( ichushi )

  49. Shunsuke Hirose, Takashi Ashikaga, Yu Hatano, Shunji Yoshikawa, Taro Sasaoka, Yasuhiro Maejima, Mitsuaki Isobe. Treatment of in-stent restenosis with excimer laser coronary angioplasty: benefits over scoring balloon angioplasty alone. Lasers Med Sci. 2016.11; 31 (8): 1691-1696. ( PubMed, DOI )

  50. Yuka Shiheido, Yasuhiro Maejima, Jun-Ichi Suzuki, Norio Aoyama, Makoto Kaneko, Ryo Watanabe, Yuriko Sakamaki, Kouji Wakayama, Yuichi Ikeda, Hiroshi Akazawa, Shizuko Ichinose, Issei Komuro, Yuichi Izumi, Mitsuaki Isobe. Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. J Mol Cell Cardiol. 2016.10; 99 123-137. ( PubMed, DOI )

  51. Daisuke Ueshima, Takashi Ashikaga, Shunji Yoshikawa, Taro Sasaoka, Yu Hatano, Ken Kurihara, Yasuhiro Maejima, Mitsuaki Isobe. Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry. J Cardiol. 2016.09; ( PubMed )

  52. Hirokazu Ohigashi, Natsuko Tamura, Yusuke Ebana, Masayoshi Harigai, Yasuhiro Maejima, Takashi Ashikaga, Mitsuaki Isobe. Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment. J Cardiol. 2016.08; ( PubMed, DOI )

  53. Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Response by Shirakabe et al to Letter Regarding Article, "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure". Circulation. 2016.08; 134 (6): e75-6. ( PubMed, DOI )

  54. Yasuhiro Maejima, Mitsuaki Isobe, Junichi Sadoshima. Regulation of autophagy by Beclin 1 in the heart. J. Mol. Cell. Cardiol.. 2016.06; 95 19-25. ( PubMed, DOI )

  55. Michinari Nakamura, Peiyong Zhai, Dominic P Del Re, Yasuhiro Maejima, Junichi Sadoshima. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight. 2016.04; 1 (5): ( PubMed, DOI )

  56. Akihiro Shirakabe, Peiyong Zhai, Yoshiyuki Ikeda, Toshiro Saito, Yasuhiro Maejima, Chiao-Po Hsu, Masatoshi Nomura, Kensuke Egashira, Beth Levine, Junichi Sadoshima. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure-Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016.02; ( PubMed, DOI )

  57. Michiko Ito, Yasuhiro Maejima, Shizuka Okazaki, Mitsuaki Isobe, Hidehisa Saeki. Generalized pustular psoriasis associated with Turner syndrome and dilated cardiomyopathy. J. Dermatol.. 2016.02; ( PubMed, DOI )

  58. Chisato Takamura, Jun-Ichi Suzuki, Masahito Ogawa, Ryo Watanabe, Yuko Tada, Yasuhiro Maejima, Hiroshi Akazawa, Issei Komuro, Mitsuaki Isobe. Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. J Cardiol. 2015.10; ( PubMed, DOI )

  59. Daisuke Ueshima, Takashi Ashikaga, Tsukasa Shimura, Yu Hatano, Taro Sasaoka, Ken Kurihara, Shunji Yoshikawa, Yasuhiro Maejima, Mitsuaki Isobe. Popliteal Retrograde Approach is Effective and Safe for Superficial Femoral Artery Chronic Total Occlusion. Ann Vasc Dis. 2015.08; 8 (3): 220-226. ( PubMed, DOI )

  60. Chikashi Terao, Takayoshi Matsumura, Hajime Yoshifuji, Yohei Kirino, Yasuhiro Maejima, Yoshikazu Nakaoka, Meiko Takahashi, Eisuke Amiya, Natsuko Tamura, Toshiki Nakajima, Tomoki Origuchi, Tetsuya Horita, Mitsuru Matsukura, Yuta Kochi, Akiyoshi Ogimoto, Motohisa Yamamoto, Hiroki Takahashi, Shingo Nakayamada, Kazuyoshi Saito, Yoko Wada, Ichiei Narita, Yasushi Kawaguchi, Hisashi Yamanaka, Koichiro Ohmura, Tatsuya Atsumi, Kazuo Tanemoto, Tetsuro Miyata, Masataka Kuwana, Issei Komuro, Yasuharu Tabara, Atsuhisa Ueda, Mitsuaki Isobe, Tsuneyo Mimori, Fumihiko Matsuda. Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap. Arthritis & rheumatology (Hoboken, N.J.). 2015.05; 67 (8): 2226-2232. ( PubMed, DOI )

  61. Daisuke Tezuka, Masahiro Terashima, Yoko Kato, Akira Toriihara, Kensuke Hirasawa, Taro Sasaoka, Shunji Yoshikawa, Yasuhiro Maejima, Takashi Ashikaga, Jun-Ichi Suzuki, Kenzo Hirao, Mitsuaki Isobe. Clinical Characteristics of Definite or Suspected Isolated Cardiac Sarcoidosis: Application of Cardiac Magnetic Resonance Imaging and (18)F-Fluoro-2-deoxyglucose Positron-Emission Tomography/Computerized Tomography. J. Card. Fail.. 2015.04; 21 (4): 313-322. ( PubMed, DOI )

  62. Sebastiano Sciarretta, Peiyong Zhai, Yasuhiro Maejima, Dominic P Del Re, Narayani Nagarajan, Derek Yee, Tong Liu, Mark A Magnuson, Massimo Volpe, Giacomo Frati, Hong Li, Junichi Sadoshima. mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1. Cell Rep. 2015.04; 11 (1): 125-136. ( PubMed, DOI )

  63. Takayoshi Matsumura, Eisuke Amiya, Natsuko Tamura, Yasuhiro Maejima, Issei Komuro, Mitsuaki Isobe. A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity. Heart Vessels. 2015.03; ( PubMed, DOI )

  64. Yasuhiro Maejima, Yun Chen, Mitsuaki Isobe, Asa B Gustafsson, Richard N Kitsis, Junichi Sadoshima. Recent Progress in Research on Molecular Mechanisms of Autophagy in the Heart. Am. J. Physiol. Heart Circ. Physiol.. 2015.02; 308 (4): H259-H268. ( PubMed, DOI )

  65. Yoshiyuki Ikeda, Akihiro Shirakabe, Yasuhiro Maejima, Peiyong Zhai, Sebastiano Sciarretta, Jessica Toli, Masatoshi Nomura, Katsuyoshi Mihara, Kensuke Egashira, Mitsuru Ohishi, Maha Abdellatif, Junichi Sadoshima. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ. Res.. 2015.01; 116 (2): 264-278. ( PubMed, DOI )

  66. Yasuhiro Maejima, Junichi Sadoshima. SUMOylation: A Novel Protein Quality Control Modifier in the Heart. Circ. Res.. 2014.09; 115 (8): 686-689. ( PubMed, DOI )

  67. Dominic P Del Re, Takahisa Matsuda, Peiyong Zhai, Yasuhiro Maejima, Mohit Raja Jain, Tong Liu, Hong Li, Chiao-Po Hsu, Junichi Sadoshima. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol. Cell. 2014.05; 54 (4): 639-650. ( PubMed, DOI )

  68. Chikashi Terao, Hajime Yoshifuji, Akinori Kimura, Takayoshi Matsumura, Koichiro Ohmura, Meiko Takahashi, Masakazu Shimizu, Takahisa Kawaguchi, Zhiyong Chen, Taeko K Naruse, Aiko Sato-Otsubo, Yusuke Ebana, Yasuhiro Maejima, Hideyuki Kinoshita, Kosaku Murakami, Daisuke Kawabata, Yoko Wada, Ichiei Narita, Junichi Tazaki, Yasushi Kawaguchi, Hisashi Yamanaka, Kimiko Yurugi, Yasuo Miura, Taira Maekawa, Seishi Ogawa, Issei Komuro, Ryozo Nagai, Ryo Yamada, Yasuharu Tabara, Mitsuaki Isobe, Tsuneyo Mimori, Fumihiko Matsuda. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am. J. Hum. Genet.. 2013.08; 93 (2): 289-297. ( PubMed, DOI )

  69. Nirmala Hariharan, Yoshiyuki Ikeda, Chull Hong, Ralph R Alcendor, Soichiro Usui, Shumin Gao, Yasuhiro Maejima, Junichi Sadoshima. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS ONE. 2013; 8 (1): e51632. ( PubMed, DOI )

  70. Yasuhiro Maejima, Jonathan Galeotti, Jeffery D Molkentin, Junichi Sadoshima, Peiyong Zhai. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload. Am. J. Physiol. Heart Circ. Physiol.. 2012.10; 303 (8): H979-H988. ( PubMed, DOI )

  71. Sebastiano Sciarretta, Peiyong Zhai, Dan Shao, Yasuhiro Maejima, Jeffrey Robbins, Massimo Volpe, Gianluigi Condorelli, Junichi Sadoshima. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012.03; 125 (9): 1134-1146. ( PubMed, DOI )

  72. Yasuhiro Maejima, Hiroyuki Okada, Go Haraguchi, Yasuyuki Onai, Hisanori Kosuge, Jun-Ichi Suzuki, Mitsuaki Isobe. Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma. Lab. Invest.. 2011.06; 91 (6): 932-944. ( PubMed, DOI )

  73. Yasuhiro Maejima, Junya Kuroda, Shouji Matsushima, Tetsuro Ago, Junichi Sadoshima. Regulation of myocardial growth and death by NADPH oxidase. J. Mol. Cell. Cardiol.. 2011.03; 50 (3): 408-416. ( PubMed, DOI )

  74. Jaeyeaon Cho, Peiyong Zhai, Yasuhiro Maejima, Junichi Sadoshima. Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ. Res.. 2011.02; 108 (4): 478-489. ( PubMed, DOI )

  75. Yasuhiro Maejima, Kiyoshi Nobori, Yuichi Ono, Susumu Adachi, Jun-Ichi Suzuki, Kenzo Hirao, Mitsuaki Isobe, Hiroshi Ito, . Synergistic effect of combined HMG-CoA reductase inhibitor and angiotensin-II receptor blocker therapy in patients with chronic heart failure: the HF-COSTAR trial. Circ. J.. 2011; 75 (3): 589-595. ( PubMed )

  76. Nirmala Hariharan, Yasuhiro Maejima, Jun Nakae, Jihye Paik, Ronald A Depinho, Junichi Sadoshima. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ. Res.. 2010.12; 107 (12): 1470-1482. ( PubMed, DOI )

  77. Chiao-Po Hsu, Peiyong Zhai, Takanobu Yamamoto, Yasuhiro Maejima, Shouji Matsushima, Nirmala Hariharan, Dan Shao, Hiromitsu Takagi, Shinichi Oka, Junichi Sadoshima. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010.11; 122 (21): 2170-2182. ( PubMed, DOI )

  78. Jun-ichi Suzuki, Masahito Ogawa, Noriko Tamura, Yasuhiro Maejima, Kiyoshi Takayama, Koji Maemura, Kazuki Honda, Yasunobu Hirata, Ryozo Nagai, Mitsuaki Isobe. A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats. Hypertens. Res.. 2010.10; 33 (10): 1060-1065. ( PubMed, DOI )

  79. Hiromitsu Takagi, Chiao-Po Hsu, Katsuya Kajimoto, Dan Shao, Yanfei Yang, Yasuhiro Maejima, Peiyong Zhai, Ghassan Yehia, Chikaomi Yamada, Daniela Zablocki, Junichi Sadoshima. Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ. Res.. 2010.09; 107 (5): 642-649. ( PubMed, DOI )

  80. Hisanori Kosuge, Takashi Ishihara, Go Haraguchi, Yasuhiro Maejima, Hiroyuki Okada, Hitoshi Saiki, Jun-ichi Suzuki, Mitsuaki Isobe. Treatment with telmisartan attenuates graft arteriosclerosis in murine cardiac allografts. J. Heart Lung Transplant.. 2010.05; 29 (5): 562-567. ( PubMed, DOI )

  81. Kazuya Isobe, Keiji Kuba, Yasuhiro Maejima, Jun-Ichi Suzuki, Shunichiro Kubota, Mitsuaki Isobe. Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model. Circ. J.. 2010.01; 74 (1): 109-119. ( PubMed )

  82. Ricardo J Gelpi, Shumin Gao, Peiyong Zhai, Lin Yan, Chull Hong, Lauren M A Danridge, Hui Ge, Yasahiro Maejima, Martin Donato, Mitsuhiro Yokota, Jeffery D Molkentin, Dorothy E Vatner, Stephen F Vatner, Junichi Sadoshima. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am. J. Physiol. Heart Circ. Physiol.. 2009.11; 297 (5): H1814-H1819. ( PubMed, DOI )

  83. Masanori Konishi, Yasuhiro Maejima, Hiroshi Inagaki, Go Haraguchi, Hitoshi Hachiya, Junichi Suzuki, Kenzo Hirao, Mitsuaki Isobe. Clinical characteristics of acute decompensated heart failure with rapid onset of symptoms. J. Card. Fail.. 2009.05; 15 (4): 300-304. ( PubMed, DOI )

  84. Takaaki Haga, Jun-Ichi Suzuki, Hisanori Kosuge, Masahito Ogawa, Hitoshi Saiki, Go Haraguchi, Yasuhiro Maejima, Mitsuaki Isobe, Toshimitsu Uede. Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. J. Mol. Cell. Cardiol.. 2009.05; 46 (5): 719-727. ( PubMed, DOI )

  85. Takahisa Matsuda, Peiyong Zhai, Yasuhiro Maejima, Chull Hong, Shumin Gao, Bin Tian, Kazumichi Goto, Hiromitsu Takagi, Mimi Tamamori-Adachi, Shigetaka Kitajima, Junichi Sadoshima. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc. Natl. Acad. Sci. U.S.A.. 2008.12; 105 (52): 20900-20905. ( PubMed, DOI )

  86. Mimi Tamamori-Adachi, Hiromitsu Takagi, Kimio Hashimoto, Kazumichi Goto, Toshinori Hidaka, Uichi Koshimizu, Kazuhiko Yamada, Ikuko Goto, Yasuhiro Maejima, Mitsuaki Isobe, Keiichi I Nakayama, Norio Inomata, Shigetaka Kitajima. Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc. Res.. 2008.11; 80 (2): 181-190. ( PubMed, DOI )

  87. Go Haraguchi, Hisanori Kosuge, Yasuhiro Maejima, Jun-Ichi Suzuki, Takasuke Imai, Masayuki Yoshida, Mitsuaki Isobe. Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis. Intensive Care Med. 2008.07; 34 (7): 1304-1312. ( PubMed, DOI )

  88. Akiyo Karube, Jun-ichi Suzuki, Go Haraguchi, Yasuhiro Maejima, Hitoshi Saiki, Hisanori Kosuge, Mitsuaki Isobe, Toshimitsu Uede. Suppression of neointimal hyperplasia after vascular injury by blocking 4-1BB/4-1BB ligand pathway. J. Med. Dent. Sci.. 2008.06; 55 (2): 207-213. ( PubMed )

  89. Hitoshi Saiki, Jun-Ichi Suzuki, Hisanori Kosuge, Go Haraguchi, Takashi Ishihara, Takaaki Haga, Yasuhiro Maejima, Mitsuaki Isobe, Toshimitsu Uede. Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts. Int Heart J. 2008.01; 49 (1): 105-118. ( PubMed )

  90. Hiroyuki Okada, Jun-ichi Suzuki, Hideki Futamatsu, Yasuhiro Maejima, Kenzo Hirao, Mitsuaki Isobe. Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. Int Heart J. 2007.09; 48 (5): 649-661. ( PubMed )

  91. Jun-ichi Suzuki, Noritaka Koga, Hisanori Kosuge, Masahito Ogawa, Go Haraguchi, Yasuhiro Maejima, Hitoshi Saiki, Mitsuaki Isobe. Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. Transplantation. 2007.04; 83 (8): 1093-1097. ( PubMed, DOI )

  92. Jun-ichi Suzuki, Masahito Ogawa, Yasuhiro Maejima, Kazuya Isobe, Hiroyuki Tanaka, Yuko M Sagesaka, Mitsuaki Isobe. Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats. J. Mol. Cell. Cardiol.. 2007.02; 42 (2): 432-440. ( PubMed, DOI )

  93. Yasuyuki Onai, Jun-Ichi Suzuki, Yasuhiro Maejima, Go Haraguchi, Susumu Muto, Akiko Itai, Mitsuaki Isobe. Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction. Am. J. Physiol. Heart Circ. Physiol.. 2007.01; 292 (1): H530-H538. ( PubMed, DOI )

  94. Hisanori Kosuge, Jun-ichi Suzuki, Go Haraguchi, Noritaka Koga, Yasuhiro Maejima, Manabu Inobe, Mitsuaki Isobe, Toshimitsu Uede. Critical role of inducible costimulator signaling in the development of arteriosclerosis. Arterioscler. Thromb. Vasc. Biol.. 2006.12; 26 (12): 2660-2665. ( PubMed, DOI )

  95. Kino Morikawa-Futamatsu, Susumu Adachi, Yasuhiro Maejima, Mimi Tamamori-Adachi, Jun-ichi Suzuki, Shigetaka Kitajima, Hiroshi Ito, Mitsuaki Isobe. HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. Life Sci.. 2006.08; 79 (14): 1380-1390. ( PubMed, DOI )

  96. Hisanori Kosuge, Go Haraguchi, Noritaka Koga, Yasuhiro Maejima, Jun-ichi Suzuki, Mitsuaki Isobe. Pioglitazone prevents acute and chronic cardiac allograft rejection. Circulation. 2006.06; 113 (22): 2613-2622. ( PubMed, DOI )

  97. Hideki Futamatsu, Jun-ichi Suzuki, Noritaka Koga, Susumu Adachi, Hisanori Kosuge, Yasuhiro Maejima, Takaaki Haga, Kenzo Hirao, Richard Horuk, Mitsuaki Isobe. A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. J. Mol. Cell. Cardiol.. 2006.06; 40 (6): 853-861. ( PubMed, DOI )

  98. Yasuhiro Maejima, Takanori Yasu, Hiroto Ueba, Nobuhiko Kobayashi, Shigemasa Hashimoto, Norifumi Kubo, Akihiro Kakehashi, Mitsuaki Isobe, Masanobu Kawakami, Muneyasu Saito. Exercise after heparin administration: new therapeutic program for patients with-option arteriosclerosis oblitrans. Circ. J.. 2005.09; 69 (9): 1099-1104. ( PubMed )

  99. Hideki Futamatsu, Jun-ichi Suzuki, Shinya Mizuno, Noritaka Koga, Susumu Adachi, Hisanori Kosuge, Yasuhiro Maejima, Kenzo Hirao, Toshikazu Nakamura, Mitsuaki Isobe. Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines. Circ. Res.. 2005.04; 96 (8): 823-830. ( PubMed, DOI )

  100. Yasuhiro Maejima, Susumu Adachi, Kino Morikawa, Hiroshi Ito, Mitsuaki Isobe. Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation. J. Mol. Cell. Cardiol.. 2005.01; 38 (1): 163-174. ( PubMed, DOI )

  101. Noritaka Koga, Jun-ichi Suzuki, Hisanori Kosuge, Go Haraguchi, Yasuyuki Onai, Hideki Futamatsu, Yasuhiro Maejima, Ryo Gotoh, Hitoshi Saiki, Fumihiko Tsushima, Miyuki Azuma, Mitsuaki Isobe. Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. Arterioscler. Thromb. Vasc. Biol.. 2004.11; 24 (11): 2057-2062. ( PubMed, DOI )

  102. Yasuhiro Maejima, Takanori Yasu, Norifumi Kubo, Koji Kawahito, Nobuhiro Omura, Takaaki Katsuki, Yoshiaki Tsukamoto, Yoshitaka Sugawara, Shigemasa Hashimoto, Yoshio Tsuruya, Taishi Hirahara, Yosuke Takagi, Nobuhiko Kobayashi, Hiroshi Funayama, Nahoko Ikeda, Takeshi Ishida, Mikihisa Fujii, Takashi Ino, Muneyasu Saito. Long-term prognosis of fulminant myocarditis rescued by percutaneous cardiopulmonary support device. Circ. J.. 2004.09; 68 (9): 829-833. ( PubMed )

  103. Yasuyuki Onai, Jun-Ichi Suzuki, Tsunekazu Kakuta, Yasuhiro Maejima, Go Haraguchi, Hiroshi Fukasawa, Susumu Muto, Akiko Itai, Mitsuaki Isobe. Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc. Res.. 2004.07; 63 (1): 51-59. ( PubMed, DOI )

  104. Yasuhiro Maejima, Hiroto Ueba, Masatoshi Kuroki, Takanori Yasu, Shigemasa Hashimoto, Aoi Nabata, Nobuhiko Kobayashi, Nahoko Ikeda, Muneyasu Saito, Masanobu Kawakami. Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth. Atherosclerosis. 2003.03; 167 (1): 89-95. ( PubMed )

  105. Yasuhiro Maejima, Takanori Yasu, Naoki Fujiwara, Takeshi Ishida, Yasuyuki Kobayashi, Masatoshi Kuroki, Norifumi Kubo, Mikihisa Fujii, Muneyasu Saito. Vasospastic total occlusion at the left main tract in a single coronary artery. Jpn. Circ. J.. 2001.12; 65 (12): 1091-1092. ( PubMed )

  106. S Ikeda, Y Takabayashi, Y Maejima, N Tachibana, T Ehara, A Nezu, Y Hoshii. Nodular lung disease with five year survival and unilateral pleural effusion in AL amyloidosis. Amyloid. 1999.12; 6 (4): 292-296. ( PubMed, DOI )

  107. K Y Wang, M B Kimmey, D A Nyberg, L A Mack, R C Haggitt, W P Shuman, D W Franklin, F E Silverstein. Colorectal neoplasms: accuracy of US in demonstrating the depth of invasion. Radiology. 1987.12; 165 (3): 827-829. ( PubMed, DOI )

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Books etc 【 display / non-display

  1. Maejima Y, Zablocki D, Sadoshima J. . Muscle 1st Edition: Fundamental Biology and Mechanisms and Disease.. Academic Press, 2012.08 Oxidative stress and cardiac muscle (ISBN : 978-0123815101)

Conference Activities & Talks 【 display / non-display

  1. Yohei Yamaguchi, Susumu Hosokawa, Yusuke Kajikawa, Yasuhiro Maejima, Mitsuaki Isobe, Tetsushi Furukawa, Shozaburo Doi. Pathophysiological Role of Dexmedetomidine for Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.. The 8th Congress of the Asia-Pacific Pediatric Cardiac Society - APPCS 2021 2021.07.15

  2. Yasuhiro Maejima. The Critical Role of Single Nucleotide Polymorphism of MLX Gene in the Pathogenesis of Large Vessel Vasculitis by Promoting Brown Adipose Tissue-Mediated Inflammatory Response in Mice. 第85回日本循環器学会学術集会 2021.03.27 神奈川県横浜市

  3. Yasuhiro Maejima. Impairment of the Protein Quality Control Systems Leads to the Pathogenesis of Heart Failure. 第85回日本循環器学会学術集会 2021.03.27 神奈川県横浜市

  4. Yasuhiro Maejima. Chemical Proteomics-Guided Identification of a Novel Target of Empagliflozin, a SGLT2 inhibitor. Seminar at RNJMS-CBMM 2019.11.19 Newark, NJ, USA

  5. Yasuhiro Maejima. Empagliflozin, a SGLT2 Inhibitor, Directly Protects Cardiomyocytes by off-target Effect-mediated Promotion of Mitophagy. American Heart Association Scientific Sessions 2019 2019.11.18 Philadelphia, PA, USA

  6. Yasuhiro Maejima. Factor Xa Exacerbates Atherosclerosis by Promoting Inflammasome Formation through PAR2-mediated Autophagy Suppression. The 3rd JCS Council Forum on Basic Cardiovascular Research 2019.09.06 東京都中央区

  7. Yasuhiro Maejima. Single Nucleotide Polymorphism of MLX Gene is Associated with the Pathogenesis of Takayasu Arteritis. 第83回日本循環器学会学術集会 2019.03.29 神奈川県横浜市

  8. Yasuhiro Maejima. The single nucleotide polymorphism of MLX gene is involved in the development of Takayasu Arteritis. The 2nd JCS Council Forum on Basic Cardiovascular Research 2018.09.23 Nara, Japan

  9. Yasuhiro Maejima, Yuka Shiheido-Watanabe, Natsuko Tamura, Yusuke Ito, Kenzo Hirao, Mitsuaki Isobe. Critical role for dipeptidyl peptidase-4 activity in the pathogenesis of experimental autoimmune myocarditis. Heart Failure Congress 2018 2018.05.29 Viena, Austria

  10. Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Masanori Konishi, Mitsuaki Isobe. Blood coagulation factor Xa promotes the progression of atherosclerosis by enhancing inflammasome formation as a consequence of PAR2-mediated autophagy inhibition. ESC Congress 2017 2017.08.26 Barcerona, Spain

  11. Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Masanori Konishi, Mitsuaki Isobe. Factor Xa Deteriorates Atherosclerosis by Facilitating Inflammasome Formation via PAR-2-mediated Autophagy Suppression. AHA Basic Cardiovascular Sciences 2017 2017.07.10 Portland, Oregon, USA

  12. Maejima Yasuhiro. TXNIP accumulation caused by single nucleotide polymorphism of MLX gene enhances inflammasome formation, thereby promoting the development of Takayasu Arteritis. The 18th International Vasculitis and ANCA Workshop  2017.03.27 Tokyo, Japan

  13. Yasuhiro Maejima, Narayani Nagarajan, Peiyong Zhai, Mitsuaki Isobe, Junichi Sadoshima. GSK-3β inhibits cardiac hypertrophy by phosphorylating FoxO1. American Heart Association Scientific Sessions 2016 2016.11.15 New Orleans, LA, USA

  14. Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Mitsuaki Isobe. Critical role for dipeptidyl peptidase-4 activity the pathogenesis of experimental autoimmune myocarditis. Basic Cardiovascular Sciences 2016 Scientific Sessions of American Heart Association 2016.07.20 Phoenix, Arizona, U.S.A.

  15. Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Ryo Watanabe, Mitsuaki Isobe. Suppression of dipeptidyl peptidase-4 activity attenuates cardiac dysfunction during autoimmune myocarditis by suppressing cathepsin-G activity. 第80回日本循環器学会学術集会 2016.03.18 宮城県仙台市

  16. Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Ryo Watanabe, Mitsuaki Isobe. Dipeptidyl peptidase-4 deteriorates cardiac function during autoimmune myocarditis by facilitating cathepsin-G activity. American Heart Association Scientific Sessions 2015 2015.11.09 Orlando, FL, USA

  17. Yasuhiro Maejima, Natsuko Tamura, Mitsuaki Isobe. Single Nucleotide Polymorphism of MLX Gene Plays a Crucial Role in the Pathogenesis of Takayasu Arteritis Through Facilitating Inflammasome Formation of the Aorta. Basic Cardiovascular Sciences 2015 Scientific Sessions of American Heart Association 2015.07 New Orleans, Louisiana, U.S.A.

  18. Yasuhiro Maejima, Natsuko Tamura, Mitsuaki Isobe. Mutation of MLX gene plays an important role in the pathogenesis of Takayasu Arteritis by promoting inflammasome formation. American Heart Association Scientific Sessions 2014 2014.11.18 Chicago, IL, USA

  19. Yasuhiro Maejima, Narayani Nagarajan, Peiyong Zhai, Mitsuaki Isobe, Junichi Sadoshima. Mst1 plays a protective role in response to ischemia in the heart by promoting C/EBP-β activation. American Heart Association Scientific Sessions 2014 2014.11.17 Chicago, IL, USA

  20. Maejima Y, Adachi S, Isobe M. Synergistic Salutary Effects of HMG-CoA Reductase Inhibitor and Angiotensin II Receptor Blocker on Load-induced Heart Failure. Basic Cardiovascular Sciences 2014 Scientific Sessions of American Heart Association 2014.07 Las Vegas, NV, U.S.A.

  21. Maejima Y, Zhai P, Isobe M, Sadoshima J. Mst1 mediates a cell-protective mechanism in the heart through phosphorylation of FoxO1 and C/EBP-β. American Heart Association Scientific Sessions 2013 2013.11 Dallas, TX, U.S.A.

  22. Yasuhiro Maejima, Mitsuaki Isobe, Junichi Sadoshima. Mst1 inhibits autophagy by promoting Beclin1-Bcl-2 interaction, thereby compromising protein quality control in failing hearts. 第77回日本循環器学会学術集会 2013.03 神奈川県横浜市

  23. Yasuhiro Maejima, Peiyong Zhai, Tong Liu, Hong Li, Junichi Sadoshima. Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell protective mechanisms in cardiomyocytes. American Heart Association Scientific Sessions 2012 2012.11 Los Angeles, CA, U.S.A.

  24. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Sadoshima J. Mst1-Mediated Phosphorylation of Beclin1 in its BH3 Domain Promotes Beclin1-Bcl-2 Interaction, Thereby Negatively Regulating Autophagy in the Heart. American Heart Association Scientific Sessions 2011 2011.11 Orlando, FL, U.S.A.

  25. Maejima Y, Kyoi S, Zhai P, Sadoshima J. Mst1 Physically Interacts with and Phosphorylates Beclin1, Thereby Negatively Regulating Autophagy in the Heart. American Heart Association Scientific Sessions 2011 2011.11 Orlando, FL, U.S.A.

  26. Maejima Y, Zhai P, Sadoshima J. GSK-3β Prevents Cardiac Dysfunction through Modulation of FoxO1 Activity Under Pressure Overload. American Heart Association Scientific Sessions 2011 2011.11 Orlando, FL, U.S.A.

  27. Maejima Y, Zhai P, Kundu M, Sadoshima J. Mammalian UNC-51-like Kinase (ULK)-1 Plays a Crucial Role in Mediating Autophagy Under Stress Conditions in the Heart. American Heart Association Scientific Sessions 2011 2011.11 Orlando, FL, U.S.A.

  28. Maejima Y, Zhai P, Sadoshima J. Mst1 Stimulates Cell Protective Mechanisms of FoxO1 Through Phosphorylation in Cardiomyocytes. American Heart Association Scientific Sessions 2010 2010.11 Chicago, IL, U.S.A.

  29. Maejima Y, Zhai P, Sadoshima J. GSK3β Inhibits Cardiac Hypertrophy through FoxO1, but Protects the Heart from Dysfunction Independently of FoxO1 under Pressure Overload. American Heart Association Scientific Sessions 2010 2010.11 Chicago, IL, U.S.A.

  30. Maejima Y, Zhai P, Yamamoto T, Matsuda T, Sadoshima J. E2F2/4 Regulated by Serine 21 Phosphorylation of GSK-3α Plays Compensatory Roles Under Pressure Overload. American Heart Association Scientific Sessions 2010 2010.11 Chicago, IL, U.S.A.

  31. Maejima Y, Sadoshima J. Mst1 Physically Interacts with and Phosphorylates FoxO1, thereby Stimulating Cell Protective Mechanisms of FoxO1 in the Heart. American Heart Association Scientific Sessions 2009 2009.11 Orlando, FL, U.S.A.

  32. Maejima Y, Zhai P, Sadoshima J. GSK3β Negatively Regulates Cardiac Hypertrophy through Activation of FoxO . American Heart Association Scientific Sessions 2009 2009.11 Orlando, FL, U.S.A.

  33. Maejima Y, Tamamori-Adachi M, Yamada K, Adachi S, Kitajima S, Isobe M. Important Role of FGF Signaling and p27kip1 in Adult Cardiomyocyte Cell Cycle Regulation . American Heart Association Scientific Sessions 2008 2008.11 New Orleans, LA, U.S.A.

  34. Maejima Y, Adachi S, Isobe M. Oxidative Stress Induce Myocardial Atrophy by Modulating Nuclear Translocation of FoxO1 Transcription Factor. 第72回日本循環器学会学術集会 2008.03 福岡県福岡市

  35. Maejima Y, Adachi S, Ito H, Isobe M. Induction of premature senescence in cardiomyocytes by oxidative stress as a novel mechanism of myocardial dysfunction. American Heart Association Scientific Sessions 2006 2006.11 Chicago, IL, U.S.A.

  36. Maejima Y, Adachi S, Ito H, Isobe M. Premature senescence can be induced by oxidative stress via PML-p53 acetylation pathway in cardiomyocytes. 第70回日本循環器学会学術集会 2006.03 愛知県名古屋市

  37. Maejima Y, Adachi S, Morikawa K, Ito H, Isobe M. Senescence-like alterations by oxidative stress is novel mechanism of cardiomyocyte dysfunction. 第69回日本循環器学会学術集会 2005.03

  38. Maejima Y, Adachi S, Morikawa K, Nobori K, Tamamori-Adachi M, Isobe M, Ito H. Nitric oxide inhibits hypoxia/reoxygenation-induced myocardial apoptosis by modulating cyclin A-associated kinase activity. American Heart Association Scientific Sessions 2003 2003.11 Orlando, FL, U.S.A.

  39. Maejima Y, Adachi S, Nobori K, Morikawa K, Tamamori-Adachi M, Ito H, Isobe M. Endogenous nitric oxide inhibits hypoxia/reoxygenation-induced myocardial apoptosis with the modulation of cyclin A-associated kinase activity. 第67回日本循環器学会学術集会 2003.03 福岡県福岡市

  40. Maejima Y, Yasu T, Iwasawa T, Ueba H, Kobayashi N, Hashimoto S, Tsuruya Y, Kubo N, Fujii M, Kawakami M, Saito M, Tsuboi J, Ino T, Kakehashi A. Exercise after heparin administration: A new therapeutic program for patient with arteriosclerosis obliterans. American Heart Association Scientific Sessions 2002 2002.11 Chicago, IL, U.S.A.

  41. Maejima Y, Ueba H, Kuroki M, Yasu T, Kobayashi N, Nabata A, Hashimoto S, Saito M, Kawakami M. Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth. 12th International Vascular Biology Meeting 2002.05 長野県軽井沢町

  42. Maejima Y, Yasu T, Iwasawa T, Ueba H, Kobayashi N, Hashimoto S, Tsuruya Y, Kubo N, Fujii M, Kuroki M, Kawakami M, Saito M, Tsuboi J, Ino T, Kakehashi A. Exercise after heparin administration, a new therapeutic program for patient with arteriosclerosis obliterans. 第66回日本循環器学会学術集会 2002.04 北海道札幌市

  43. Maejima Y, Ueba H, Kuroki M, Yasu T, Nabata A, Ikeda N, Kobayashi N, Hashimoto S, Saito M, Kawakami M. Nitric oxide production is required for hepatocyte growth factor-stimulated endothelial cell growth. 10th International Symposium of Cardiovascular Pharmacology 2001.03 京都府京都市

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Awards & Honors 【 display / non-display

  • Star Reviewer 2017, American Physiological Society,American Physiological Society,2018.11

  • Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences,American Heart Association,2012.11

  • Louis N. and Arnold M. Katz Basic Research Prize,American Heart Association,2011.11

  • BCVS Abstract Travel Award 2010,American Heart Association,2010.11

  • BCVS Abstract Travel Award 2009,American Heart Association,2009.11

  • BCVS New Investigator Travel Award 2009,American Heart Association,2009.07

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Performance of duties 【 display / non-display

  • ,2015.07 - Now

  • ,2014.04 - Now

  • ,2014.04 - 2015.03

  • ,2013.08 - Now

  • ,2012.10 - 2013.07

  • ,2006.04 - 2008.03

  • ,2006.04 - 2008.03

  • ,2005.04 - Now

  • ,2005.04 - Now

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