Personnel Information

写真a

OHKAWA Ryunosuke


Job title

Professor

Mail Address

ohkawa.alc@tmd.ac.jp

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Campus Career 【 display / non-display 】

  • 2013.10
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Health Care Sciences， Biomedical Laboratory Sciences， Moleculo-genetic Sciences， Analytical Laboratory Chemistry， Assistant Professor
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Laboratory Sciences， Department of Analytical Laboratory Chemistry， Assistant Professor
  • 2019.04
    -
    2020.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Laboratory Sciences， Department of Analytical Laboratory Chemistry， Professor
  • 2020.05
    -
    2023.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Laboratory Sciences， Department of Analytical Laboratory Chemistry， Professor
  • 2023.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Laboratory Sciences， Department of Clinical Bioanalysis and Molecular Biology， Professor
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External Career 【 display / non-display 】

  • 2002.04
    -
    2010.03
    , Medical Technologist
  • 2007.04
    -
    Now
    , Visiting Lecturer
  • 2013.04
    -
    Now
    , Visiting Lecturer
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Research Areas 【 display / non-display 】

  • Others

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Qualification Acquired 【 display / non-display 】

  • Medical Technologist

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Published Papers & Misc 【 display / non-display 】

  1. Akiko Futatsugi, Minoru Tozuka, Yuna Horiuchi, Ryunosuke Ohkawa, Tomoki Kosho. High-density lipoprotein functionality in cholesterol efflux in early childhood is related to the content ratio of triglyceride to cholesterol. Sci Rep. 2024.10; 14 (1): 23323. ( PubMed, DOI )

  2. Masamichi Mikame, Nelson Hirokazu Tsuno, Yoshino Miura, Hideaki Kitazaki, Daisuke Uchimura, Toru Miyazaki, Toru Miyagi, Takayuki Onodera, Wataru Ohashi, Takahiro Kameda, Ryunosuke Ohkawa, Shuichi Kino, Kazuo Muroi. Decreased rate of blood donors with high ABO antibody titers in Japan and the underlying factors: Comparisons between 2010 and 2021. Transfus Apher Sci. 2023.12; 62 (6): 103812. ( PubMed, DOI )

  3. Azusa Yamazaki, Yoko Nukui, Takahiro Kameda, Ryoichi Saito, Yuki Koda, Naoya Ichimura, Shuji Tohda, Ryunosuke Ohkawa. Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality. Sci Rep. 2023.12; 13 (1): 21493. ( PubMed, DOI )

  4. Masamichi Mikame, Nelson Hirokazu Tsuno, Yoshino Miura, Hideaki Kitazaki, Daisuke Uchimura, Toru Miyagi, Toru Miyazaki, Takayuki Onodera, Wataru Ohashi, Takahiro Kameda, Ryunosuke Ohkawa, Shuichi Kino, Kazuo Muroi.. Anti-A and anti-B titers, age, gender, biochemical parameters, and body mass index in Japanese blood donors. Immunohematology. 2023.12; 39 (4): 155-165. ( PubMed, DOI )

  5. Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa. Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase. Biochimie. 2023.09; 218 34-45. ( PubMed, DOI )

  6. Tsunehiro Miyakoshi, Yume Mutsuda, Yuna Horiuchi, Takahiro Kameda, Minoru Tozuka, Ryunosuke Ohkawa. Improvement in bilirubin influence on cholesterol efflux capacity evaluation using the immobilized liposome-bound gel beads method. Biosci Rep. 2023.06; 43 (6): ( PubMed, DOI )

  7. Ohkawa R.. Quiz Section!! APFCB News. 2023.03; 1 99-102.

  8. Yume Mutsuda, Tsunehiro Miyakoshi, Yuna Horiuchi, Takahiro Kameda, Minoru Tozuka, Ryunosuke Ohkawa. Development and validation of novel automatable assay for cholesterol efflux capacity. Biosci Rep. 2023.02; 43 (2): ( PubMed, DOI )

  9. Ogino M, Kameda T, Mutsuda Y, Tanaka H, Takahashi J, Okazaki M, Ai M, Ohkawa R. Development of internal standard for lipoprotein subclass analysis using dual detection gel-permeation high-performance liquid chromatography system. Bioscience reports. 2022.05; 42 (6): ( PubMed, DOI )

  10. Yuna Horiuchi, Shao-Jui Lai, Takahiro Kameda, Minoru Tozuka, Ryunosuke Ohkawa. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: Confirmation and improvement for application in clinical laboratory. Ann Clin Biochem. 2022.03; 59 (2): 134-143. ( PubMed, DOI )

  11. Takahiro Kameda, Yuna Horiuchi, Shitsuko Shimano, Kouji Yano, Shao-Jui Lai, Naoya Ichimura, Shuji Tohda, Yuriko Kurihara, Minoru Tozuka, Ryunosuke Ohkawa. N-homocysteinylation of high-density lipoprotein on endothelial repair function. Biol Chem. 2021.08; ( PubMed, DOI )

  12. Tamaki Kobayashi, Makoto Kurano, Mai Nanya, Tomo Shimizu, Ryunosuke Ohkawa, Minoru Tozuka, Yutaka Yatomi. Glycation of HDL Polymerizes Apolipoprotein M and Attenuates Its Capacity to Bind to Sphingosine 1-Phosphate. J Atheroscler Thromb. 2021.07; 28 (7): 730-741. ( PubMed, DOI )

  13. Azusa Yamazaki, Ryunosuke Ohkawa, Yuka Yamagata, Yuna Horiuchi, Shao-Jui Lai, Takahiro Kameda, Naoya Ichimura, Shuji Tohda, Minoru Tozuka. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL). Biol Chem. 2021.05; 402 (4): 439-449. ( PubMed, DOI )

  14. Yasunori Iwata, Shinji Kitajima, Junya Yamahana, Shuji Shimomura, Shiori Yoneda-Nakagawa, Norihiko Sakai, Kengo Furuichi, Hisayuki Ogura, Koichi Sato, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Ryunosuke Ohkawa, Makoto Kurano, Yutaka Yatomi, Takashi Wada. Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis Int J Rheum Dis. 2021.02; 24 (2): 231-239. ( PubMed, DOI )

  15. Shitsuko Shimano, Ryunosuke Ohkawa, Mayu Nambu, Mai Sasaoka, Azusa Yamazaki, Yuki Fujii, Yuna Horiuchi, Shao-Jui Lai, Takahiro Kameda, Naoya Ichimura, Koji Fujita, Shuji Tohda, Minoru Tozuka. Marked Changes in Serum Amyloid A Distribution and High-Density Lipoprotein Structure during Acute Inflammation. Biomed Res Int. 2021; 2021 9241259. ( PubMed, DOI )

  16. Ryunosuke Ohkawa, Hann Low, Nigora Mukhamedova, Ying Fu, Shao-Jui Lai, Mai Sasaoka, Ayuko Hara, Azusa Yamazaki, Takahiro Kameda, Yuna Horiuchi, Peter J Meikle, Gerard Pernes, Graeme Lancaster, Michael Ditiatkovski, Paul Nestel, Boris Vaisman, Denis Sviridov, Andrew Murphy, Alan T Remaley, Dmitri Sviridov, Minoru Tozuka. Cholesterol transport between red blood cells and lipoproteins contributes to cholesterol metabolism in blood. J Lipid Res. 2020.12; 61 (12): 1577-1588. ( PubMed, DOI )

  17. Hann Low, Nigora Mukhamedova, Luciano Dos Santos Aggum Capettini, Yining Xia, Irena Carmichael, Stephen H Cody, Kevin Huynh, Michael Ditiatkovski, Ryunosuke Ohkawa, Michael Bukrinsky, Peter J Meikle, Soo-Ho Choi, Seth Field, Yury I Miller, Dmitri Sviridov. Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein). Arterioscler. Thromb. Vasc. Biol.. 2020.08; 40 (10): ATVBAHA120315037. ( PubMed, DOI )

  18. Yuna Horiuchi, Shao-Jui Lai, Takahiro Kameda, Minoru Tozuka, Ryunosuke Ohkawa. Comparison of a novel cholesterol efflux assay using immobilized liposome-bound gel beads with the conventional method. Biosci. Rep.. 2020.07; ( PubMed, DOI )

  19. Nigora Mukhamedova, Anh Hoang, Dragana Dragoljevic, Larisa Dubrovsky, Tatiana Pushkarsky, Hann Low, Michael Ditiatkovski, Ying Fu, Ryunosuke Ohkawa, Peter J Meikle, Anelia Horvath, Beda Brichacek, Yury I Miller, Andrew Murphy, Michael Bukrinsky, Dmitri Sviridov. Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. PLoS Pathog.. 2019.07; 15 (7): e1007907. ( PubMed, DOI )

  20. Shao-Jui Lai, Ryunosuke Ohkawa, Yuna Horiuchi, Tetsuo Kubota, Minoru Tozuka. Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages. Biol. Chem.. 2019.06; ( PubMed, DOI )

  21. Horiuchi Y., Ohkawa R., Lai S., Shimano S., Hagihara M., Tohda S., Tozuka M.. Availability of ApoB-depleted serum in clinical assay for cholesterol efflux capacity using immobilized liposome-bound gel beads CLINICA CHIMICA ACTA. 2019.06; 493 S78-S79. ( DOI )

  22. Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Shitsuko Shimano, Michio Hagihara, Shuji Tohda, Takahiro Kameda, Minoru Tozuka. Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads. Biosci. Rep.. 2019.03; ( PubMed, DOI )

  23. Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Azusa Yamazaki, Hayato Ikoma, Kouji Yano, Takahiro Kameda, Minoru Tozuka. Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells. Biol. Chem.. 2019.01; 400 (2): 209-218. ( PubMed, DOI )

  24. Megumi Sato, Ryunosuke Ohkawa, Hann Low, Madoka Nishimori, Shigeo Okubo, Akira Yoshimoto, Kouji Yano, Takahiro Kameda, Yutaka Yatomi, Minoru Tozuka. Serum amyloid A does not affect high-density lipoprotein cholesterol measurement by a homogeneous assay. Clin. Biochem.. 2019.01; 63 97-101. ( PubMed, DOI )

  25. Yuko Mishima, Makoto Kurano, Tamaki Kobayashi, Masako Nishikawa, Ryunosuke Ohkawa, Minoru Tozuka, Yutaka Yatomi. Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate. Biosci. Rep.. 2018.10; 38 (5): ( PubMed, DOI )

  26. Hitoshi Ikeda, Mariko Kobayashi, Hiromitsu Kumada, Kenichiro Enooku, Kazuhiko Koike, Makoto Kurano, Masaya Sato, Takahiro Nojiri, Tamaki Kobayashi, Ryunosuke Ohkawa, Satoshi Shimamoto, Koji Igarashi, Junken Aoki, Yutaka Yatomi. Performance of autotaxin as a serum marker for liver fibrosis. Ann. Clin. Biochem.. 2018.07; 55 (4): 469-477. ( PubMed, DOI )

  27. Horiuchi, Y; Lai, SJ; Yamazaki, A; Nakamura, A; Ohkawa, R; Yano, K; Kameda, T; Okubo, S; Shimano, S; Hagihara, M; Tohda, S; Tozuka, M. VALIDATION AND APPLICATION OF A NOVEL CHOLESTEROL EFFLUX ASSAY USING IMMOBILIZED LIPOSOMES AS A SUBSTITUTE FOR CULTURED CELLS ATHEROSCLEROSIS SUPPLEMENTS. 2018.06; 32 59. ( DOI )

  28. Yuna Horiuchi, Shao-Jui Lai, Azusa Yamazaki, Ayaka Nakamura, Ryunosuke Ohkawa, Kouji Yano, Takahiro Kameda, Shigeo Okubo, Shitsuko Shimano, Michio Hagihara, Shuji Tohda, Minoru Tozuka. Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells. Biosci. Rep.. 2018.04; 38 (2): ( PubMed, DOI )

  29. Ryunosuke Ohkawa, Makoto Kurano, Noboru Sakai, Tatsuya Kishimoto, Takahiro Nojiri, Koji Igarashi, Shigemi Hosogaya, Yukio Ozaki, Tomotaka Dohi, Katsumi Miyauchi, Hiroyuki Daida, Junken Aoki, Shigeo Okubo, Hitoshi Ikeda, Minoru Tozuka, Yutaka Yatomi. Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay. Sci. Rep.. 2018.03; 8 (1): 4725. ( PubMed, DOI )

  30. Hassan Ahmed, Dohi Tomotaka, Miyauchi Katsumi, Ogita Manabu, Kurano Makoto, Ohkawa Ryunosuke, Nakamura Kazuhiro, Tamura Hiroshi, Isoda Kikuo, Okazaki Shinya, Yatomi Yutaka, Daida Hiroyuki. Homocysteine値とhomocysteine thiolactonase活性が経皮冠動脈インターベンションを受ける患者の長期臨床アウトカムに与える予後的影響(Prognostic impact of homocysteine levels and homocysteine thiolactonase activity on long-term clinical outcomes in patients undergoing percutaneous coronary intervention) Journal of Cardiology. 2017.06; 69 (5-6): 830-835. ( ichushi )

  31. Makoto Kurano, Kuniyuki Kano, Tomotaka Dohi, Hirotaka Matsumoto, Koji Igarashi, Masako Nishikawa, Ryunosuke Ohkawa, Hitoshi Ikeda, Katsumi Miyauchi, Hiroyuki Daida, Junken Aoki, Yutaka Yatomi. Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome. J. Lipid Res.. 2017.02; 58 (2): 433-442. ( PubMed, DOI )

  32. Yoshimoto, A., Ohkawa, R., Yano, K., Sato, M., Ichimura, N., Usami, Y., Miyazaki, A., Sugano, M., Uehara, T., and Tozuka, M.. Paraoxonase 1 associated with high-density lipoprotein transfers to oxidized low-density lipoprotein depending on the degree of oxidation. Int J Anal Bio-Sci. 2016.12; 4 (4): 99-109.

  33. Y Nagura, N H Tsuno, K Kano, A Inoue, J Aoki, Y Hirowatari, M Kaneko, M Kurano, M Matsuhashi, R Ohkawa, M Tozuka, Y Yatomi, H Okazaki. Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. Transfus Med. 2016.10; 26 (5): 365-372. ( PubMed, DOI )

  34. Ahmed Hassan, Tomotaka Dohi, Katsumi Miyauchi, Manabu Ogita, Makoto Kurano, Ryunosuke Ohkawa, Kazuhiro Nakamura, Hiroshi Tamura, Kikuo Isoda, Shinya Okazaki, Yutaka Yatomi, Hiroyuki Daida. Prognostic impact of homocysteine levels and homocysteine thiolactonase activity on long-term clinical outcomes in patients undergoing percutaneous coronary intervention. J Cardiol. 2016.09; 69 (6): 830-835. ( PubMed, DOI )

  35. Megumi Sato, Ryunosuke Ohkawa, Akira Yoshimoto, Kouji Yano, Naoya Ichimura, Madoka Nishimori, Shigeo Okubo, Yutaka Yatomi, Minoru Tozuka. Effects of serum amyloid A on the structure and antioxidant ability of high-density lipoprotein. Biosci. Rep.. 2016.07; ( PubMed, DOI )

  36. Kouji Yano, Ryunosuke Ohkawa, Megumi Sato, Akira Yoshimoto, Naoya Ichimura, Takahiro Kameda, Tetsuo Kubota, Minoru Tozuka. Cholesterol Efflux Capacity of Apolipoprotein A-I Varies with the Extent of Differentiation and Foam Cell Formation of THP-1 Cells. J Lipids. 2016; 2016 9891316. ( PubMed, DOI )

  37. Naoya Ichimura, Megumi Sato, Akira Yoshimoto, Kouji Yano, Ryunosuke Ohkawa, Takeshi Kasama, Minoru Tozuka. High-Density Lipoprotein Binds to Mycobacterium avium and Affects the Infection of THP-1 Macrophages. J Lipids. 2016; 2016 4353620. ( PubMed, DOI )

  38. Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Junya Yamahana, Ryunosuke Ohkawa, Koji Igarashi, Junken Aoki, Shuichi Kaneko, Yutaka Yatomi, Takashi Wada. Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy. Intern. Med.. 2016; 55 (3): 215-221. ( PubMed, DOI )

  39. Ryunosuke Ohkawa, Makoto Kurano, Yuko Mishima, Takahiro Nojiri, Yasunori Tokuhara, Tatsuya Kishimoto, Kazuhiro Nakamura, Shigeo Okubo, Shigemi Hosogaya, Yukio Ozaki, Hiromitsu Yokota, Koji Igarashi, Hitoshi Ikeda, Minoru Tozuka, Yutaka Yatomi. Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. Clin. Biochem.. 2015.07; 48 (10-11): 690-697. ( PubMed, DOI )

  40. Makoto Kurano, Akiko Suzuki, Asuka Inoue, Yasunori Tokuhara, Kuniyuki Kano, Hirotaka Matsumoto, Koji Igarashi, Ryunosuke Ohkawa, Kazuhiro Nakamura, Tomotaka Dohi, Katsumi Miyauchi, Hiroyuki Daida, Kazuhisa Tsukamoto, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi. Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic Acid in acute coronary syndrome. Arterioscler. Thromb. Vasc. Biol.. 2015.02; 35 (2): 463-470. ( PubMed, DOI )

  41. Makoto Kurano, Kazuhisa Tsukamoto, Masumi Hara, Ryunosuke Ohkawa, Hitoshi Ikeda, Yutaka Yatomi. LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate. J. Biol. Chem.. 2015.01; 290 (4): 2477-2488. ( PubMed, DOI )

  42. Takahiro Kameda, Ryunosuke Ohkawa, Kouji Yano, Yoko Usami, Akari Miyazaki, Kazuyuki Matsuda, Kenji Kawasaki, Mitsutoshi Sugano, Tetsuo Kubota, Minoru Tozuka. Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein. J Lipids. 2015; 2015 592594. ( PubMed, DOI )

  43. Satoshi Nishimura, Mika Nagasaki, Shinichi Okudaira, Junken Aoki, Tsukasa Ohmori, Ryunosuke Ohkawa, Kazuhiro Nakamura, Koji Igarashi, Hiroshi Yamashita, Koji Eto, Kansei Uno, Naoto Hayashi, Takashi Kadowaki, Issei Komuro, Yutaka Yatomi, Ryozo Nagai. ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity. Diabetes. 2014.12; 63 (12): 4154-4164. ( PubMed, DOI )

  44. Kenichiro Enooku, Hayato Nakagawa, Yoko Soroida, Ryunosuke Ohkawa, Yuko Kageyama, Baasanjav Uranbileg, Naoko Watanabe, Ryosuke Tateishi, Haruhiko Yoshida, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda. Increased serum mitochondrial creatine kinase activity as a risk for hepatocarcinogenesis in chronic hepatitis C patients. Int. J. Cancer. 2014.08; 135 (4): 871-879. ( PubMed, DOI )

  45. Shiori Ito, Soichiro Iwaki, Rie Kondo, Masashi Satoh, Kazuya Iwabuchi, Ryunosuke Ohkawa, Yuko Mishima, Yutaka Yatomi, Tomoo Furumoto, Hiroyuki Tsutsui, Satoshi Fujii. TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: implications for inflammation in atherosclerosis. Coron. Artery Dis.. 2014.06; 25 (4): 311-320. ( PubMed, DOI )

  46. Mayuko Kondo, Takeaki Ishizawa, Kenichiro Enooku, Yasunori Tokuhara, Ryunosuke Ohkawa, Baasanjav Uranbileg, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Norihiro Kokudo, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda. Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma. Clin. Chim. Acta. 2014.06; 433 128-134. ( PubMed, DOI )

  47. Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Matsuura, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda. High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential. Int. J. Cancer. 2014.05; 134 (9): 2189-2198. ( PubMed, DOI )

  48. Yasunori Tokuhara, Kenichi Shukuya, Masami Tanaka, Mariko Mouri, Ryunosuke Ohkawa, Midori Fujishiro, Tomoo Takahashi, Shigeo Okubo, Hiromitsu Yokota, Makoto Kurano, Hitoshi Ikeda, Seiji Yamaguchi, Shinobu Inagaki, Mika Ishige-Wada, Hiromi Usui, Yutaka Yatomi, Tatsuo Shimosawa. Detection of novel visible-light region absorbance peaks in the urine after alkalization in patients with alkaptonuria. PLoS ONE. 2014; 9 (1): e86606. ( PubMed, DOI )

  49. Junko Iino, Makoto Osada, Makoto Kurano, Makoto Kaneko, Ryunosuke Ohkawa, Yumiko Satoh, Shigeo Okubo, Yukio Ozaki, Minoru Tozuka, Nelson H Tsuno, Yutaka Yatomi. Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. Lipids Health Dis. 2014; 13 150. ( PubMed, DOI )

  50. Shiori Ito, Soichiro Iwaki, Keiko Koike, Yuichiro Yuda, Ayako Nagasaki, Ryunosuke Ohkawa, Yutaka Yatomi, Tomoo Furumoto, Hiroyuki Tsutsui, Burton E Sobel, Satoshi Fujii. Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. Coron. Artery Dis.. 2013.12; 24 (8): 642-650. ( PubMed, DOI )

  51. Yutaka Nagura, Nelson H Tsuno, Ryunosuke Ohkawa, Takahiro Nojiri, Yasunori Tokuhara, Mika Matsuhashi, Yutaka Yatomi, Koki Takahashi. Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA-1 whole blood. Transfusion. 2013.12; 53 (12): 3139-3148. ( PubMed, DOI )

  52. R Kanai, T Iijima, S Hashimoto, H Nakazawa, H Ohnishi, T Yorozu, R Ohkawa, T Nojiri, M Shimizu, H Okazaki. Impact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study. Transfus Med. 2013.10; 23 (5): 344-350. ( PubMed, DOI )

  53. Yoshishige Miyabe, Chie Miyabe, Yoshiko Iwai, Aiko Takayasu, Shin Fukuda, Waka Yokoyama, Jun Nagai, Masahiro Jona, Yasunori Tokuhara, Ryunosuke Ohkawa, Harald M Albers, Huib Ovaa, Junken Aoki, Jerold Chun, Yutaka Yatomi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki. Necessity of lysophosphatidic acid receptor 1 for development of arthritis. Arthritis Rheum.. 2013.08; 65 (8): 2037-2047. ( PubMed, DOI )

  54. Tomotaka Dohi, Katsumi Miyauchi, Ryunosuke Ohkawa, Kazuhiro Nakamura, Makoto Kurano, Tatsuya Kishimoto, Naotake Yanagisawa, Manabu Ogita, Tadashi Miyazaki, Akihisa Nishino, Kenji Yaginuma, Hiroshi Tamura, Takahiko Kojima, Ken Yokoyama, Takeshi Kurata, Kazunori Shimada, Hiroyuki Daida, Yutaka Yatomi. Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome. Atherosclerosis. 2013.07; 229 (1): 192-197. ( PubMed, DOI )

  55. Makoto Kurano, Kazuhisa Tsukamoto, Ryunosuke Ohkawa, Masumi Hara, Junko Iino, Yuko Kageyama, Hitoshi Ikeda, Yutaka Yatomi. Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. Atherosclerosis. 2013.07; 229 (1): 102-109. ( PubMed, DOI )

  56. Hitoshi Ikeda, Kenichiro Enooku, Ryunosuke Ohkawa, Kazuhiko Koike, Yutaka Yatomi. Plasma lysophosphatidic acid levels and hepatocellular carcinoma. Hepatology. 2013.01; 57 (1): 417-418. ( PubMed, DOI )

  57. Hayakazu Sumida, Kazuhiro Nakamura, Keisuke Yanagida, Ryunosuke Ohkawa, Yoshihide Asano, Takafumi Kadono, Kunihiko Tamaki, Koji Igarashi, Junken Aoki, Shinichi Sato, Satoshi Ishii, Takao Shimizu, Yutaka Yatomi. Decrease in circulating autotaxin by oral administration of prednisolone. Clin. Chim. Acta. 2013.01; 415 74-80. ( PubMed, DOI )

  58. 11. 蔵野 信，大川 龍之介，池田 均，矢冨 裕. スフィンゴシン1-リン酸-基礎から臨床へ 臨床化学. 2013; 42 242-249.

  59. Yoshikazu Ono, Makoto Kurano, Ryunosuke Ohkawa, Hiromitsu Yokota, Koji Igarashi, Junken Aoki, Minoru Tozuka, Yutaka Yatomi. Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. Lipids Health Dis. 2013; 12 20. ( PubMed, DOI )

  60. Ryunosuke Ohkawa, Tatsuya Kishimoto, Makoto Kurano, Tomotaka Dohi, Katsumi Miyauchi, Hiroyuki Daida, Mika Nagasaki, Kansei Uno, Naoto Hayashi, Noboru Sakai, Naoto Matsuyama, Takahiro Nojiri, Kazuhiro Nakamura, Shigeo Okubo, Hiromitsu Yokota, Hitoshi Ikeda, Yutaka Yatomi. Development of an enzymatic assay for sphingomyelin with rapid and automatable performances: Analysis in healthy subjects and coronary heart disease patients. Clin. Biochem.. 2012.11; 45 (16-17): 1463-1470. ( PubMed, DOI )

  61. Tomotaka Dohi, Katsumi Miyauchi, Ryunosuke Ohkawa, Kazuhiro Nakamura, Shuta Thuboi, Manabu Ogita, Tadashi Miyazaki, Akihisa Nishino, Ken Yokoyama, Takeshi Kurata, Yutaka Yatomi, Hiroyuki Daida. Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography. Ann. Clin. Biochem.. 2012.11; 49 (Pt 6): 527-533. ( PubMed, DOI )

  62. Kazuhiro Nakamura, Koji Igarashi, Ryunosuke Ohkawa, Hiromitsu Yokota, Akiko Masuda, Shunsuke Nakagawa, Tetsu Yano, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi. Serum autotaxin is not a useful biomarker for ovarian cancer. Lipids. 2012.09; 47 (9): 927-930. ( PubMed, DOI )

  63. Yoko Soroida, Ryunosuke Ohkawa, Hayato Nakagawa, Yumiko Satoh, Haruhiko Yoshida, Hiroto Kinoshita, Ryosuke Tateishi, Ryota Masuzaki, Kenichiro Enooku, Shuichiro Shiina, Takahisa Sato, Shuntaro Obi, Tadashi Hoshino, Ritsuko Nagatomo, Shigeo Okubo, Hiromitsu Yokota, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda. Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence. J. Hepatol.. 2012.08; 57 (2): 330-336. ( PubMed, DOI )

  64. Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Nobuyuki Ohte, Shiori Ito, Soichiro Iwaki, Yuji Hirowatari, Ryunosuke Ohkawa, Yuko Mishima, Yutaka Yatomi, Genjiro Kimura, Satoshi Fujii. Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. Coron. Artery Dis.. 2012.06; 23 (4): 234-238. ( PubMed, DOI )

  65. Tomotaka Dohi, Katsumi Miyauchi, Ryunosuke Ohkawa, Kazuhiro Nakamura, Tatsuya Kishimoto, Tadashi Miyazaki, Akihisa Nishino, Naohisa Nakajima, Kenji Yaginuma, Hiroshi Tamura, Takahiko Kojima, Ken Yokoyama, Takeshi Kurata, Kazunori Shimada, Yutaka Yatomi, Hiroyuki Daida. Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome. Clin. Chim. Acta. 2012.01; 413 (1-2): 207-212. ( PubMed, DOI )

  66. Tomotaka Dohi, Katsumi Miyauchi, Shinya Okazaki, Takayuki Yokoyama, Ryunosuke Ohkawa, Kazuhiro Nakamura, Naotake Yanagisawa, Shuta Tsuboi, Manabu Ogita, Ken Yokoyama, Takeshi Kurata, Yutaka Yatomi, Hiroyuki Daida. Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome. Atherosclerosis. 2011.12; 219 (2): 907-912. ( PubMed, DOI )

  67. Akiko Masuda, Tomoyuki Fujii, Yuki Iwasawa, Kazuhiro Nakamura, Ryunosuke Ohkawa, Koji Igarashi, Shinichi Okudaira, Hitoshi Ikeda, Shiro Kozuma, Junken Aoki, Yutaka Yatomi. Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension. Clin. Chim. Acta. 2011.10; 412 (21-22): 1944-1950. ( PubMed, DOI )

  68. Hayato Nakagawa, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Ryota Masuzaki, Ryosuke Tateishi, Haruhiko Yoshida, Naoko Watanabe, Kazuaki Tejima, Yukio Kume, Tomomi Iwai, Atsushi Suzuki, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Masao Omata, Koji Igarashi, Junken Aoki, Kazuhiko Koike, Yutaka Yatomi. Autotaxin as a novel serum marker of liver fibrosis. Clin. Chim. Acta. 2011.06; 412 (13-14): 1201-1206. ( PubMed, DOI )

  69. Kazuhiro Nakamura, Koji Igarashi, Ryunosuke Ohkawa, Naoya Saiki, Mika Nagasaki, Kansei Uno, Naoto Hayashi, Tetsuji Sawada, Kenichi Syukuya, Hiromitsu Yokota, Hiroyuki Arai, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi. A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples. Clin. Chim. Acta. 2010.08; 411 (15-16): 1090-1094. ( PubMed, DOI )

  70. Hitoshi Ikeda, Ryunosuke Ohkawa, Naoko Watanabe, Kazuhiro Nakamura, Yukio Kume, Hayato Nakagawa, Haruhiko Yoshida, Shigeo Okubo, Hiromitsu Yokota, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Kazuhiko Koike, Yutaka Yatomi. Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. Clin. Chim. Acta. 2010.05; 411 (9-10): 765-770. ( PubMed, DOI )

  71. Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Eur. J. Pharmacol.. 2010.05; 634 (1-3): 121-131. ( PubMed, DOI )

  72. Toshiyuki Imasawa, Hiroshi Kitamura, Ryunosuke Ohkawa, Yumiko Satoh, Akiko Miyashita, Yutaka Yatomi. Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy. Exp. Toxicol. Pathol.. 2010.01; 62 (1): 53-60. ( PubMed, DOI )

  73. 西村 智，長崎 実佳，中村 和宏，大川 龍之介，田嶋 美智子，良永 千穂，宇野 漢成，真鍋 一郎，永井 良三，林 直人，矢冨 裕. 血清リン脂質・生合成系を用いた新規メタボリックシンドロームマーカーの探索 脂質生化学研究. 2010; 52 237-238.

  74. Harumasa Nakazawa, Hiroaki Ohnishi, Hitoshi Okazaki, Shiho Hashimoto, Hajime Hotta, Takashi Watanabe, Ryunosuke Ohkawa, Yutaka Yatomi, Kazunori Nakajima, Yasuhide Iwao, Shigeru Takamoto, Masaru Shimizu, Takehiko Iijima. Impact of fresh-frozen plasma from male-only donors versus mixed-sex donors on postoperative respiratory function in surgical patients: a prospective case-controlled study. Transfusion. 2009.11; 49 (11): 2434-2441. ( PubMed, DOI )

  75. Kazuhiro Nakamura, Ryunosuke Ohkawa, Shigeo Okubo, Hiromitsu Yokota, Hitoshi Ikeda, Yutaka Yatomi, Koji Igarashi, Kazufumi Ide, Tatsuya Kishimoto, Akiko Masuda, Tomotaka Yamamoto, Shoji Tsuji, Nobuhito Saito, Mineo Kurokawa, Shinichi Okudaira, Junken Aoki. Autotaxin enzyme immunoassay in human cerebrospinal fluid samples. Clin. Chim. Acta. 2009.07; 405 (1-2): 160-162. ( PubMed, DOI )

  76. 西村 智，長崎 実佳，中村 和宏，大川 龍之介，田嶋 美智子，若林 香織，宇野 漢成，真鍋 一郎，永井 良三，林 直人，矢冨 裕. 血清リン脂質・生合成系の変化は加齢・慢性炎症に伴うメタボリックシンドロームの発症を規定する 脂質生化学研究. 2009; 51 298-299.

  77. Atsushi Kimura, Tsukasa Ohmori, Yuji Kashiwakura, Ryunosuke Ohkawa, Seiji Madoiwa, Jun Mimuro, Kuniko Shimazaki, Yuichi Hoshino, Yutaka Yatomi, Yoichi Sakata. Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. Stroke. 2008.12; 39 (12): 3411-3417. ( PubMed, DOI )

  78. Akiko Masuda, Kazuhiro Nakamura, Koji Izutsu, Koji Igarashi, Ryunosuke Ohkawa, Masahiro Jona, Katsumi Higashi, Hiromitsu Yokota, Shinichi Okudaira, Tatsuya Kishimoto, Takuro Watanabe, Yukako Koike, Hitoshi Ikeda, Yasushi Kozai, Mineo Kurokawa, Junken Aoki, Yutaka Yatomi. Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma. Br. J. Haematol.. 2008.10; 143 (1): 60-70. ( PubMed, DOI )

  79. Shigemi Hosogaya, Yutaka Yatomi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Shigeo Okubo, Hiromitsu Yokota, Masato Ohta, Hirokazu Yamazaki, Toru Koike, Yukio Ozaki. Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity. Ann. Clin. Biochem.. 2008.07; 45 (Pt 4): 364-368. ( PubMed, DOI )

  80. Ryunosuke Ohkawa, Kazuhiro Nakamura, Shigeo Okubo, Shigemi Hosogaya, Yukio Ozaki, Minoru Tozuka, Noriko Osima, Hiromitsu Yokota, Hitoshi Ikeda, Yutaka Yatomi. Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters. Ann. Clin. Biochem.. 2008.07; 45 (Pt 4): 356-363. ( PubMed, DOI )

  81. Kazuhiro Nakamura, Koji Igarashi, Kazufumi Ide, Ryunosuke Ohkawa, Shigeo Okubo, Hiromitsu Yokota, Akiko Masuda, Noriko Oshima, Takumi Takeuchi, Masaomi Nangaku, Shinichi Okudaira, Hiroyuki Arai, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation. Clin. Chim. Acta. 2008.02; 388 (1-2): 51-58. ( PubMed, DOI )

  82. Kazuhiro Nakamura, Masaomi Nangaku, Ryunosuke Ohkawa, Shigeo Okubo, Hiromitsu Yokota, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi. Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome. Clin. Chem. Lab. Med.. 2008; 46 (1): 150-151. ( PubMed, DOI )

  83. Kazuhiro Nakamura, Takumi Takeuchi, Ryunosuke Ohkawa, Shigeo Okubo, Hiromitsu Yokota, Minoru Tozuka, Junken Aoki, Hiroyuki Arai, Hitoshi Ikeda, Noriko Ohshima, Tadaichi Kitamura, Yutaka Yatomi. Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients. Ann. Clin. Biochem.. 2007.11; 44 (Pt 6): 549-556. ( PubMed, DOI )

  84. Naoko Watanabe, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Yukio Kume, Tomoaki Tomiya, Kazuaki Tejima, Takako Nishikawa, Masahiro Arai, Mikio Yanase, Junken Aoki, Hiroyuki Arai, Masao Omata, Kenji Fujiwara, Yutaka Yatomi. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci.. 2007.09; 81 (12): 1009-1015. ( PubMed, DOI )

  85. Kazuhiro Nakamura, Tatsuya Kishimoto, Ryunosuke Ohkawa, Shigeo Okubo, Minoru Tozuka, Hiromitsu Yokota, Hitoshi Ikeda, Noriko Ohshima, Koji Mizuno, Yutaka Yatomi. Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro: proposal of a plasma sample preparation method for laboratory testing of these lipids. Anal. Biochem.. 2007.08; 367 (1): 20-27. ( PubMed, DOI )

  86. Naoko Watanabe, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Yukio Kume, Junken Aoki, Kotaro Hama, Shinichi Okudaira, Masayuki Tanaka, Tomoaki Tomiya, Mikio Yanase, Kazuaki Tejima, Takako Nishikawa, Masahiro Arai, Hiroyuki Arai, Masao Omata, Kenji Fujiwara, Yutaka Yatomi. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J. Clin. Gastroenterol.. 2007.07; 41 (6): 616-623. ( PubMed, DOI )

  87. Yumiko Satoh, Ryunosuke Ohkawa, Kazuhiro Nakamura, Katsumi Higashi, Makoto Kaneko, Hiromitsu Yokota, Junken Aoki, Hiroyuki Arai, Yasuhito Yuasa, Yutaka Yatomi. Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6. Eur. J. Haematol.. 2007.06; 78 (6): 510-517. ( PubMed, DOI )

  88. Kazuhiro Nakamura, Ryunosuke Ohkawa, Shigeo Okubo, Minoru Tozuka, Mitsumasa Okada, Shinya Aoki, Junken Aoki, Hiroyuki Arai, Hitoshi Ikeda, Yutaka Yatomi. Measurement of lysophospholipase D/autotaxin activity in human serum samples. Clin. Biochem.. 2007.02; 40 (3-4): 274-277. ( PubMed, DOI )

  89. Atsushi Kimura, Tsukasa Ohmori, Ryunosuke Ohkawa, Seiji Madoiwa, Jun Mimuro, Takashi Murakami, Eiji Kobayashi, Yuichi Hoshino, Yutaka Yatomi, Yoichi Sakata. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells. 2007.01; 25 (1): 115-124. ( PubMed, DOI )

  90. Ryunosuke Ohkawa, Nobuo Hisano, Kazuhiro Nakamura, Shigeo Okubo, Hiromitsu Yokota, Yutaka Yatomi. Lysophospholipase D activity exists in the urine to catalyse the formation of lysophosphatidic acid. Nephrol. Dial. Transplant.. 2006.12; 21 (12): 3612-3613. ( PubMed, DOI )

  91. Masayuki Tanaka, Shinichi Okudaira, Yasuhiro Kishi, Ryunosuke Ohkawa, Sachiko Iseki, Masato Ota, Sumihare Noji, Yutaka Yatomi, Junken Aoki, Hiroyuki Arai. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem.. 2006.09; 281 (35): 25822-25830. ( PubMed, DOI )

  92. Ryunosuke Ohkawa, Yuji Hirowatari, Kazuhiro Nakamura, Shigeo Ohkubo, Hitoshi Ikeda, Mitsumasa Okada, Minoru Tozuka, Kazuhiko Nakahara, Yutaka Yatomi. Platelet release of beta-thromboglobulin and platelet factor 4 and serotonin in plasma samples. Clin. Biochem.. 2005.11; 38 (11): 1023-1026. ( PubMed, DOI )

  93. 久米 幸夫，日暮 公野，大川 龍之介，名倉 豊，大久保 滋夫，曽根 伸治，眞重 文子，福本 誠二，高橋 孝喜，中原 一彦. 梅毒関連項目の自動化(その２) Prestige24iを用いた基礎的検討(梅毒脂質抗体) 日本臨床検査自動化学会会誌. 2003.09; 28 (4): 413.

  94. 久米 幸夫，日暮 公野，大川 龍之介，名倉 豊，大久保 滋夫，曽根 伸治，眞重 文子，福本 誠二，高橋 孝喜，中原 一彦. 梅毒関連項目の自動化(その３) Prestige24iを用いた基礎的検討(抗TP抗体) 日本臨床検査自動化学会会誌. 2003.09; 28 (4): 414.

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Books etc 【 display / non-display 】

  1. Yatomi, Y., Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Suzuki, A., Kishimoto, T., Ikeda, H., and Aoki, J.. Lysophospholipid Receptors: Signaling and Biochemistry. Wiley， 2013 Clinical introduction of lysophosphatidic acid (LPA) and autotaxin assays

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Conference Activities & Talks 【 display / non-display 】

  1. Nobuharu Suzuki, Hinako Saito, Riko Takahashi, Nanako Yamada, Mio Fujisato, Kanoko Mitsunari, Binri Sasaki, Yukina Hosoda, Chikako Hayashi, Toru Doi, Mikael Simons, and Ryunosuke Ohkawa. The maintenance of small diameter axons after dysmyelination in teneurin-4 deficient mice. . CELL BIO24 (An ASCB/EMBO Meeting) 2024.12.15 San Diego, CA, US.

  2. Ohkawa R. Tips for identifying and managing abnormal reaction curves. 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB) Congress 2024.11.03 Sydney

  3. Someya Y., Shibuya M., Sun C., Yamazaki A., Miyakoshi T., Kawaguchi R., Yoshimoto A., Ohkawa R.. Establishment of a method for measuring apolipoproteins transfer rates between high-density lipoprotein and very lowdensity lipoprotein by ELISA. 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB) Congress 2024.11.01 Sydney

  4. Yamazaki A., Yoshimoto A., Ichimura N., Tohda S., Ohkawa R. Validation and Application of Direct Measurement Method for Erythrocytes Cholesterol Content. 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB) Congress 2024.11.01 Sydney

  5. Akiyama H., Miyakoshi T., Kawaguchi R., Kameda T., Yoshimoto A., Ohkawa R. Effect of Cholesterol Loading on the Assay for ABCA1-mediated Cholesterol Efflux Capacity using THP-1 cells and BODIPY-cholesterol. 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB) Congress 2024.11.01 Sydney

  6. Horiuchi Y., Miyakoshi T., Tozuka M., Ohkawa R. Development, improvement and clinical application of cholesterol efflux capacity assay in cell-free systems. 第56回日本医療検査科学会年次学術集会 2024.10.06 横浜

  7. Ohkawa R.. How Should We Evaluate High-Density Lipoprotein?. International Medini Healthcare Conference 2024 In conjunction with MIMLS 33rd National Scientific Conference 2024.09.24 Johor Bahru

  8. Ohkawa R. High-density lipoprotein - small particles with a big impact -. The 46th Annual Conference of The Association of Medical Technologists of Thailand (ACMTT) 2024.06.13 Bangkok

  9. Miyakoshi T., Akiyama H, Horiuchi Y., Araki M., Yonetsu T., Yoshimoto A., Tozuka M., Sasano T., Ohkawa R. Comparison of clinical usefulness of CEC assays by immobilized liposome-bound magnetic beads method and conventional cell-dependent assay targeting at coronary artery plaque size. European Atherosclerosis Society (EAS) 92nd Congress 2024.05.27 Lyon

  10. Yamazaki A., Yokoyama S., Okazaki M., Ai M., Miyake S., Takahashi J., Kameda T., Ichimura N., Tohda S., Ohkawa R. Influence of lipoprotein(a) on the accuracy of LDL-cholesterol measurement. European Atherosclerosis Society 92nd Congress 2024.05.27 Lyon

  11. Kawaguchi R., Yoshimoto A., Kameda T., Ohkawa R. Serum Analysis, not Isolated HDL Analysis, Reveals a New Effect of Homocysteine Modification on HDL Paraoxonase 1 Activities and Distribution. European Atherosclerosis Society (EAS) 92nd Congress 2024.05.27 Lyon

  12. Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Chikako Hayashi, Ryunosuke Ohkawa, and Nobuharu Suzuki. The molecular mechanism of axon maintenance after myelination defect. 第46回日本分子生物学会年会 2023.12.08

  13. Miyakoshi T., Horiuchi Y., Araki M., Yonetsu T., Watanabe M., Nakamura M., Kameda T., Yoshimoto A., Ichimura N., Tohda S., Tozuka M., Sasano T., Ohkawa R. Association between CEC measured by immobilized liposome-bound gel beads method and the size of lipid-rich coronary artery plaque. Scientific Session of the American Heart Association 2023.11.09 Philadelphia

  14. Horiuchi Y., Kameda T., Ogura M., Miida T., Tozuka M., Ohkawa R. Search for standardizable references in cell-free cholesterol efflux assay using immobilized liposome-bound gel beads. the 12th International Congress on Lipid & Atherosclerosis with Asia-Australia Vascular Biology Meeting (ICoLA 2023 in conjunction with AAVBM) 2023.09.15 Seoul

  15. Ohkawa R.. Structural and Functional Analysis of Modified HDL. Lunchtime Seminar at Chulalongkorn University 2023.08.18 Bangkok

  16. Miyakoshi T., Mutsuda Y., Horiuchi Y., Kameda T., Tozuka M., Ohkawa R. Application of bilirubin oxidase for improvement of false positive error caused by bilirubin on cholesterol efflux capacity assay by immobilize liposome-bound gel beads method. American Association for Clinical Chemistry (AACC) 2023 AACC Annual Scientific Meeting & Clinical Lab Expo 2023.07.24 Anaheim

  17. Yamazaki A., Nukui Y., Kameda T., Saito R., Koda Y., Ichimura N., Tohda S., Ohkawa R.. Usefulness of presepsin and thrombomodulin measurements for predicting COVID-19 mortality. American Association for Clinical Chemistry (AACC) 2023 AACC Annual Scientific Meeting & Clinical Lab Expo 2023.07.24 Anaheim

  18. Mikame M., Tsuno N.H., Miura Y., Kitazaki H., Uchimura D., Miyagi T., Miyazaki T., Onodera T., Ohashi W., Kameda T., Ohkawa R., Kino S., Muroi K. Correlation of ABO antibody titers with physiological/biochemical parameters in Japanese blood donors, and comparison between donors of 2010 and 2021. 33rd Regional Congress of the ISBT 2023.06.17 Gothenburg

  19. Kawaguchi R., Kameda T., Yoshimoto A., and Ohkawa R. Usefulness of Apolipoprotein B-Depleted Serum in Paraoxonase 1 Assessment. Worldlab EuroMedLab Roma 2023 2023.05.21 Roma

  20. Ohkawa R.. Japanese Medical Technology Education - Connection Potential for Cooperation Between Japan and Vietnam Schools/Association -. The Workshop On the Diamond Jubilee Celebration of the 60 years of Da Nang University of Medical Technology and Pharmacy (DUMTP) 2023.04.14 Da Nang City (Vietnam)

  21. Yamazaki A., Kameda T., Ichimura N., Tohda S., and Ohkawa R. Investigation of Assays for Cholesterol Content of Erythrocytes. The 17th Congress of Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM) 2022.10.09 神戸

  22. Ogino M., Kameda T., and Ohkawa R. Improvement of serum antioxidant capacity assay using 1,1-diphenyl-2-picrylhydrazyl. The 17th Congress of Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM) 2022.10.09 神戸

  23. Kawaguchi R., Kameda T., Yoshimoto A., and Ohkawa R. The effect of high-density lipoprotein N-homocysteinylation on paraoxnase1 activities and distribution. The 17th Congress of Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM) 2022.10.09 神戸

  24. Yamada T., Kameda T., and Ohkawa R.. Investigation of very low-density lipoprotein-triglyceride hydrolysis assessment. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.27 Chicago

  25. Ikenaga A., Kameda T. and Ohkawa R.. Chymase truncation of apolipoprotein E in high-density lipoprotein is further promoted under myeloperoxidase oxidation. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  26. Ohkawa R., Mutsuda Y., Horiuchi Y., Kameda T., and Tozuka M.. Development and validation of novel automatable assay for cholesterol efflux capacity. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  27. Kameda T., Ogino M., Kawaguchi R., Shibuya M., Yamada T., Ikenaga A., Sun C., and Ohkawa R.. Effects of serum amyloid A on the structure and antioxidant ability of low-density lipoprotein. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  28. Yamazaki A., Fujii Y., Kameda T., Ichimura N., Tohda S., and Ohkawa R.. Investigation of Assays for Cholesterol Content of Erythrocytes Membrane. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  29. Sun C., Kameda T., Ikenaga A., and Ohkawa R.. Improved method for quantification of apoA-I/apoA-II heterodimer in high-density lipoprotein. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  30. Kawaguchi R., Kameda T., Yoshimoto A., and Ohkawa R.. The effect of sampling procedure and substrate type for activity assay on PON1 assessment. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  31. Ogino M., Kameda, Mutsuda Y., Tanaka H., Takahashi J., Okazaki M., Ai M., and Ohkawa R. Development of internal standard for lipoprotein subclass analysis using dual detection gel-permeation HPLC system. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  32. Kameda T., Ogino M., Kawaguchi R., Shibuya M., Yamada T., Ikenaga A., Sun C., and Ohkawa R... Effects of serum amyloid A on the structure and antioxidant ability of low-density lipoprotein. American Association for Clinical Chemistry (AACC) 2022 AACC Annual Scientific Meeting & Clinical Lab Expo 2022.07.26 Chicago

  33. Horiuchi Y., Kameda T., Ichimura N., Kina K., Miyake K., Tohda S., Tozuka M., Miida T., and Ohkawa R. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: validation of condition in polyethylene glycol precipitation procedure.. The 19th International Symposium on Atherosclerosis 2021.10.24 Kyoto

  34. Mutsuda Y., Kameda T., Tanaka H., Takahashi J., Okazaki M., Ai M., and Ohkawa R. Analysis of apolipoproteins distribution in subdivided lipoprotein fractions applying LipoSEARCH system. The 19th International Symposium on Atherosclerosis 2021.10.24 Kyoto

  35. Ohkawa R.. Education for international activities and international joint research. 日本医療検査科学会第53回大会 2021.10.10 横浜

  36. Horiuchi Y., Lai SJ., Shimano S., Kameda T., Ichimura N., Tohda S., Tozuka M. and Ohkawa R. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  37. Ohkawa R., Low H., Mukhamedova N., Fu Y., Lai SJ., Sasaoka M., Horiuchi Y., Ditiatkovski M., Nestel P., Sviridov D., and Tozuka M. Evaluation of cholesterol uptake and efflux by red blood cells. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  38. Shimano S., Ohkawa R., Nambu M., Sasaoka M., Yamazaki A., Fujii Y., Igarashi K., Horiuchi Y., Lai SJ., Kameda T., Ichimura N., Fujita K., Tohda S. and Tozuka M. Dramatic change of high-density lipoprotein structure and serum amyloid A distribution after orthopedic surgery. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  39. Ryunosuke Ohkawa. Various types of research networks for medical technology, Keynote Speech. the 5th congress of AASMT (ASEAN Association of Schools of Medical Technology) 2020.11.05 Viet Nam (on-line)

  40. Ryunosuke Ohkawa. Japanese laboratory medicine and its education, Country Reports. the 5th congress of AASMT (ASEAN Association of Schools of Medical Technology) 2020.11.05 Viet Nam (on-line)

  41. Fujii Y., Ohkawa R., Lai SJ., Horiuchi Y., Shimano S., Ohno K., Ichimura N., Hagihara M., Tozuka M., Tohda S. Analysis of Serum Amyloid A Containing HDL Formation in HepG2. 2019 KAMT congress & International conference 2019.08.31 Pyeongchang

  42. Yamazaki A., Ohkawa R., Horiuchi Y., Lai SJ., Shimano S., Itoi A., Ichimura N., Hagihara M., Tozuka M., Tohda S. Analysis of Apolipoprotein C-II and C-III Transfers between High-density Lipoprotein and Very Low-density Lipoprotein. 2019 KAMT congress & International conference 2019.08.31 Pyeongchang

  43. Horiuchi Y., Ohkawa R., Lai SJ., Shimano S., Hagihara M., Tohda S., and Tozuka M. Availability of apoB-depleted serum in clinical assay for cholesterol efflux capacity using immobilized liposome-bound gel beads. 3rd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine 2019.05.19 Barcelona

  44. Tozuka M., Horiuchi Y., Lai S.J., Ohkawa R.. Development of a novel method to estimate the cholesterol efflux capacity of high-density lipoprotein. 2018 TMU Medical Laboratory Forum 2018.10.29

  45. Ohkawa R.. Lost in translation: cholesterol metabolism in red blood cells. Immunometabolism meeting 2018.08.29 Victoria, Australia

  46. Lai SJ., Ohkawa R., Horiuchi Y., Yamazaki A., Nakamura A., Tozuka M. Possible Concern of Erythrocytes with Reverse Cholesterol Transport. 70th AACC Annual Scientific Meeting & Clinical Lab Expo 2018.08.02 Chicago

  47. Horiuchi Y., Lai SJ., Yamazaki A., Nakamura A., Ohkawa R., Yano K., Kameda T., Okubo S., Hagihara M., Tohda S., and Tozuka M. Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells. The XVIIIth International Symposium on Atherosclerosis 2018.07.09 Toronto

  48. Tsuzura A., Yoshimori M., Konnno K., Imadome K., Onozawa E., Ohkawa R., Tozuka M., Miura O., Arai A. Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages by Secreting Humoral Factors. The 59th American Society of Hematology Annual Meeting 2017.12.11 Atlanta

  49. Tamaki K., Kurano M., Mishima Y., Nojiri T., Ohkawa R., Minoru T., Yatomi Y. Glycation of apolipoprotein M attenuated its capacity to bind sphingosine 1-phosphate. 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) 2017.11.17 Kyoto

  50. Horiuchi Y., Ohkawa R., Ikoma H., Lai SJ., Yano K., Tozuka M. Cholesterol efflux capacity of apoE-containing HDL. 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) 2017.11.17 Kyoto

  51. Nakamura A., Ohkawa R., Yano K., Kameda T., Tozuka M. Effect of oxidized LDL and HDL on monocyte chemotactic protein-1 secretion of HUVEC. 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) 2017.11.17 Kyoto

  52. Kameda T., Ohkawa R., Nakamura A., Horiuchi Y., Yamazaki A., Lai SJ., Tozuka M. Effect of myeloperoxidase oxidation and N-homocysteinylation of HDL on its endothelial repair function. 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) 2017.11.17 Kyoto

  53. Mishima Y., Kurano M., Kobayashi T., Nishikawa M., Ohkawa R., Tozuka M., Yatomi Y. Difference between sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in their preference to HDL or albumin. 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) 2017.11.17 Kyoto

  54. Yoshimoto A., Ohkawa R., Sato M., Yano K., Tozuka M. Oxidized low-density lipoprotein receives antioxidant enzyme paraoxonase 1 from high-density lipoprotein. 14th Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress 2016.11.27 Taipei

  55. Ohkawa R., Lai SJ., Yoshimoto A., Sato M., Yano K., Tozuka M. Impact of Erythrocyte on the cholesterol metabolism. 14th Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress 2016.11.27 Taipei

  56. Lai SJ., Ohkawa R., Yano K., Sato M., Yoshimoto A., Tozuka M. Erythrocyte is associated with cholesterol efflux from foam cell by apolipoprotein A-I. 14th Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress 2016.11.27 Taipei

  57. Ikoma H., Ohkawa R., Yoshimoto A., Yano K., Sato M., Kasama T. Analysis of oxidative susceptibility and fatty acid profile in apolipoprotein E-containing high-density lipoprotein. 14th Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress 2016.11.27 Taipei

  58. Ohkawa R. Dos and Donts of Clinical Laboratory Research. IFCC-TFYS Educational Webinar Series 2016.11.11 On-line

  59. Morita M., Ohkawa R., Satou M., Yoshimoto A., Yano K., Kasama T., Tozuka M. Modification of apolipoprotein A-I in high-density lipoprotein by myeloperoxidase and chymase. The 32nd World Congress of Biomedical Laboratory Science. 2016.09.02 Hyogo

  60. Ohkawa R., Tozuka M.. “What is” and “How to make” Leader of Biomedical Laboratory Scientist?. The 32nd World Congress of Biomedical Laboratory Science. 2016.09.02 Hyogo

  61. Kobayashi T., Kurano M., Nojiri T., Ohkawa R., Tozuka M., Okubo S., Yatomi Y. Oxidation and glycation modulate HDL capacity to carry Sphingosine 1-phosphate, an Anti-atherosclerotic Bioactive Lipid. The 32nd World Congress of Biomedical Laboratory Science. 2016.09.02 Hyogo

  62. Sato M., Ohkawa R., Yoshimoto A., Yano K., Okubo S., Yatomi Y., Tozuka M.. Effect of SAA on the antioxidant ability of HDL. American Association for Clinical Chemistry (AACC) 2016 Annual Meeting and Clinical Lab Expo 2016.07.31 Philadelphia

  63. Yano K., Ohkawa R., Sato M., Yoshimoto A., Kubota T., Tozuka M.. Effect of differentiation and foam cell formation on cholesterol efflux capacity of apolipoprotein A-I.. American Association for Clinical Chemistry (AACC) 2016 Annual Meeting and Clinical Lab Expo 2016.07.31 Philadelphia

  64. Yoshimoto A., Sato M., Yano K., Usami Y., Miyazaki A., Sugano M., Ohkawa R., Tozuka M. Paraoxonase1 participates in antioxidant ability of HDL as a constituent protein but not its enzymatic activity. the 21st IFCC-EFLM (European Congress of Clinical Chemistry and Laboratory Medicine) 2015.06.22 Paris

  65. Ohkawa R. IFCC TF-YS open meeting, Workforce preparation the invitation to contribution. the 21st IFCC-EFLM (European Congress of Clinical Chemistry and Laboratory Medicine) 2015.06.22 Paris

  66. Mamiya S., Yoshimoto A., Sato M., Ohkawa R., Tozuka M. Lipid hydroperoxides in apolipoprotein E-containing high-density lipoprotein. American Association for Clinical Chemistry (AACC) 2014 Annual Meeting and Clinical Lab Expo 2014.07.27 Chicago

  67. Sato M., Ohkawa R., Kameda T., Yoshimoto A., Okubo S., Yatomi Y., Tozuka M.. Effect of SAA on the structure and measurement method of HDL. American Association for Clinical Chemistry (AACC) 2014 Annual Meeting and Clinical Lab Expo 2014.07.27 Chicago

  68. Kameda T., Usami Y., Sagae N., Ohkawa R., Tozuka M. Effects of myeloperoxidase-modified HDL on reverse cholesterol transport and monocytic migration. American Association for Clinical Chemistry (AACC) 2014 Annual Meeting and Clinical Lab Expo 2014.07.27 Chicago

  69. Ohkawa R., Kishimoto T., Kurano M., Dohi T., Miyauchi K., Daida H., Nagasaki M., Uno K., Hayashi N., Sakai N., Matsuyama N., Nojiri T., Nakamura K., Okubo S., Yokota H., Ikeda H., Yatomi Y. Possible Usefulness of the Assay of Choline and Choline-containing Phospholipids in Clinical Laboratory Medicine in the Fields of Dyslipidemia and Atherosclerosis. Scientific Session of the American Heart Association 2013.11.03 Los Angeles

  70. Sugiura T., Dohi Y., Yamashita S., Ohte N., Ito S., Sanagawa A., Iwaki S. Ohkawa R., Mishima Y., Yatomi Y., Kimura G., Fujii S.. Circulating MicroRNA-126 as a Potential Biomarker for Recovery from Smoking-Related Endothelial Damage. Scientific Session of the American Heart Association 2013.11.03 Los Angeles

  71. Kurano M., Tsukamoto K., Ohkawa R., Hara M., Iino J., Ikeda H., Yatomi Y.. Hepatic Apolipoprotein M Overexpression Increased Total Sphingosine 1-phosphate Mass and Ameliorate Insulin Resistance in Diet Induced Obesity Mice. Scientific Session of the American Heart Association 2013.11.03 Los Angeles

  72. Fujii S., Iwaki S., Ito S., Nagasaki A., Ohkawa R., Yatomi Y., Furumoto T.. Increased Plasma Sphingosine-1-Phosphate (S1P) and Its Capacity to Increase Expression of Plasminogen Activator Inhibitor-1 In Adipocytes and Obese Subjects. Scientific Session of the American Heart Association 2013.11.03 Los Angeles

  73. Sawada T., Nakamura K., Ohkawa R., Shoji A., Tahara K., Hayashi H., Kimura E., Igarashi K., Aoki J. and Yatomi Y.. Serum Phosphatidylserine-Specific Phospholipase A1 (PS-PLA1) Identified As a Novel Biomarker for Systemic Lupus Erythematosus (SLE). ACR/ARHP Annual Meeting 2012.11.09

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  • Ryunosuke Ohkawa,Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB),Communication and Publication Committee member，2023.02.10 - Now

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