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Graduating School 【 display / non-display 】
Graduating School 【 display / non-display 】
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Gunma University, 1998.03, Graduated
Graduate School 【 display / non-display 】
Graduate School 【 display / non-display 】
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The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2006.03, Completed
Campus Career 【 display / non-display 】
Campus Career 【 display / non-display 】
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2013.03-2015.02Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Associate Professor
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2013.03-2018.02Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Associate Professor
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2015.03-2016.02Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， a， Associate Professor
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2015.12-NowInstitute of Science Tokyo， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Cellular and Molecular Medicine， Associate Professor
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2018.03Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Associate Professor
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2018.05-2019.04Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Visiting Lecturer
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2019.05-2020.03Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Oncology， Visiting Lecturer
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2020.05-2023.06Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Oncology， Visiting Lecturer
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2023.07-2024.09Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Medical Biochemistry， Professor
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2024.10-NowInstitute of Science Tokyo， -， Graduate Schools， Bio-Matrix， Department of Medical Biochemistry， Professor
External Career 【 display / non-display 】
External Career 【 display / non-display 】
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2013.03-2018.03Tokyo Medical and Dental University, Depatment of Cellular and Molecular Medicine, Associate Professor
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2018.04-2023.06Nippon Medical School, Department of Biochemistry and Molecular Biology, Professor, Chair
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2018.08-2020.07Ministry of Education, Culture, Sports, Science and Technology-Japan, Program Officer
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2023.07-Now, Professor
Academic Activity 【 display / non-display 】
Academic Activity 【 display / non-display 】
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2020.02-NowAMED AMED application form evaluation committee
Research Areas 【 display / non-display 】
Qualification Acquired 【 display / non-display 】
Research Theme 【 display / non-display 】
Research Theme 【 display / non-display 】
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Mechanisms of chronic inflammation on the axis of cellular cholesterol metabolism, 2020.04 - 2023.03
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Mechanisms regulating inflammation-regeneration network, 2020.04 - 2022.03
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The development of bioresorbable arterial graft that promote the vascular remodeling by macrophage infiltration from the outside of the graft, 2019.04 - 2022.03
Summary： In bioresorbable arterial graft, the vascular structure needs to be regenerated before the bioresorbable material is absorbed completely. We developed a bilayer graft with a sponge inner layer to promote cell infiltration and an electrospun outer layer to endure arterial pressure. In vitro studies revealed that sheets with pore sizes of 2um and 10um showed inadequate cell infiltration, while sheets with 20um were technically difficult to fabricate. The ideal bilayered graft was difficult to create using this method. In the future, grafts with a hierarchical structure with different absorption periods will be prepared.
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Novel therapeutic strategy for atherosclerosis, 2017.04 - 2020.03
Summary： Recent studies unraveled that cellular metabolism is tightly linked to activation of immune cells. While accumulation of extracellular/intracellular cholesterol has been shown to lead to macrophage activation and dysfunction, the underlying mechanisms remain incompletely understood. Here, we provide evidence that cellular cholesterol is required for macrophage activation. Accordingly, suppression of cholesterol accumulation by a novel supramolecular compound, polyrotaxane (PRX) inhibited Myd88-dependent macrophage inflammatory activation. Moreover, PRX treatment inhibited atherosclerotic plaque formation in Ldlr-/- mice. The finding that dynamic changes in cellular cholesterol directly regulate Myd88-dependent inflammatory programs in macrophages suggests the potential for new therapeutic and diagnostic approaches for chronic inflammatory diseases, such as atherosclerosis.
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Dysregulation of immune system and metabolic system that leads to the chronic inflammation in macrophage, 2014.04 - 2017.03
Summary： It is recognized that macrophages play pivotal roles in the initiation and progression of chronic inflammatory diseases. In response to inflammatory activation via TLR4, macrophages rapidly activate glycolysis, increase inflammatory cytokine expression, acquire M1-like, pro-inflammatory phenotype. By contrast, macrophages increase unsaturated fatty acid synthesis to show M2-like, anti-inflammatory phenotype in the late inflammatory response at 24-48 hour after TLR4 activation. It is likely that unsaturated fatty acids inhibit inflammatory signal, induce anti-inflammatory genes simultaneously by acting as ligands of GPCR and nuclear receptors. These results suggest the functional switch from M1-like to M2-like, and the metabolic switch from glycolysis to lipid metabolism are tightly linked and coordinately regulated during inflammatory response, and these temporal regulatory programs are important for proper inflammatory activation and resolution.
Published Papers & Misc 【 display / non-display 】
Published Papers & Misc 【 display / non-display 】
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Yumiko Oishi, Nathanael J Spann, Verena M Link, Evan D Muse, Tobias Strid, Chantle Edillor, Matthew J Kolar, Takashi Matsuzaka, Sumio Hayakawa, Jenhan Tao, Minna U Kaikkonen, Aaron F Carlin, Michael T Lam, Ichiro Manabe, Hitoshi Shimano, Alan Saghatelian, Christopher K Glass. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab.. 2017.02; 25 (2): 412-427. ( PubMed, DOI )
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Yumiko Oishi, Shinichiro Hayashi, Takayuki Isagawa, Motohiko Oshima, Atsushi Iwama, Shigeki Shimba, Hitoshi Okamura, Ichiro Manabe. Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. Sci Rep. 2017.08; 7 (1): 7086. ( PubMed, DOI )
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Shinichiro Hayashi, Ichiro Manabe, Yumi Suzuki, Frédéric Relaix, Yumiko Oishi. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Elife. 2016.10; 5 ( PubMed, DOI )
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Rumi Hachiya, Takuya Shiihashi, Ibuki Shirakawa, Yorihiro Iwasaki, Yoshihiro Matsumura, Yumiko Oishi, Yukiteru Nakayama, Yoshihiro Miyamoto, Ichiro Manabe, Kozue Ochi, Miyako Tanaka, Nobuhito Goda, Juro Sakai, Takayoshi Suganami, Yoshihiro Ogawa. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Sci Rep. 2016.06; 6 28845. ( PubMed, DOI )
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Yumiko Oishi, Ichiro Manabe. Macrophages in age-related chronic inflammatory diseases Aging and Mechanisms of Disease. 2016.07; 2 16018. ( DOI )
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Yumiko Oishi, Ichiro Manabe. Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin. Exp. Pharmacol. Physiol.. 2016.03; 43 (3): 294-303. ( PubMed, DOI )
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Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA. descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Nature communications. 2024.06; 15 (1): 4941. ( PubMed, DOI )
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Oishi, Y; Koike, H; Kumagami, N; Nakagawa, Y; Araki, M; Taketomi, Y; Miki, Y; Matsuda, S; Kim, H; Matsuzaka, T; Ozawa, H; Shimano, H; Murakami, M; Manabe, I. Macrophage SREBP1 regulates skeletal muscle regeneration (vol 14, 1251784, 2024) FRONTIERS IN IMMUNOLOGY. 2024.04; 15 1382077. ( PubMed, DOI )
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Narai-Kanayama A, Hayakawa S, Yoshino T, Honda F, Matsuda H, Oishi Y. Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation. Biochimica et biophysica acta. Biomembranes. 2024.04; 1866 (5): 184312. ( PubMed, DOI )
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Sukhorukov VN, Khotina VA, Borodko DD, Ekta MB, Oishi Y, Omelchenko AV, Kolmychkova KI, Nikiforov NG, Sobenin IA, Orekhov AN. Evidence for the Involvement of Gene Regulation of Inflammatory Molecules in the Accumulation of Intracellular Cholesterol: The Mechanism of Foam Cell Formation in Atherosclerosis. Current medicinal chemistry. 2024.02; ( PubMed, DOI )
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Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages 2023.01; 14 1009973. ( PubMed, DOI )
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Cyclic stretch regulates immune responses via tank‐binding kinase 1 expression in macrophages 2022.12; 13 (1): 185-194. ( PubMed, DOI )
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Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, Manabe I, Oishi Y. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. JCI insight. 2022.11; 7 (22): ( PubMed, DOI )
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Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration 2022.11; 42 (1): 48. ( PubMed, DOI )
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Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration 2022.11; 13 (1): 7058. ( PubMed, DOI )
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Koike Hiroyuki, Manabe Ichiro, Oishi Yumiko. 骨格筋再生における協調的細胞間相互作用のメカニズム(Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration) Inflammation and Regeneration. 2022.11; 42 1 of 11-11 of 11. ( ichushi )
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Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF‑binding protein. 2022.07; 61 (1): ( PubMed, DOI )
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Iwasaki Toshio, Miyajima-Nakano Yoshiharu, Fukazawa Risako, Lin Myat T., Matsushita Shin-ichi, Hagiuda Emi, Taguchi Alexander T., Dikanov Sergei A., Oishi Yumiko, Gennis Robert B.. 蛋白質の構造機能相関を調査するための大腸菌アミノ酸要求性発現宿主株(Escherichia coli amino acid auxotrophic expression host strains for investigating protein structure-function relationships) The Journal of Biochemistry. 2021.04; 169 (4): 387-394. ( ichushi )
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Plasma and follicular fluid osteopontin levels during ovarian cycle and their correlation with follicular fluid vascular endothelial growth factor levels. 2021.01; 11 (1): 286. ( PubMed, DOI )
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Higuchi Tadashi, Yamaguchi Fumio, Asakura Takayuki, Yoshida Daizo, Oishi Yumiko, Morita Akio. 超音波は神経膠腫細胞において蛍光強度とアミノレブリン酸に対するABCG2 mRNA反応を調節する(Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells) Journal of Nippon Medical School. 2020.12; 87 (6): 310-317. ( ichushi )
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Kitazawa, M; Hayashi, S; Imamura, M; Takeda, S; Oishi, Y; Kaneko-Ishino, T; Ishino, F. Deficiency and overexpression of <i>Rtl1</i> in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes DEVELOPMENT. 2020.11; 147 (21): ( PubMed, DOI )
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A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. 2020.06; 117 (25): 14365-14375. ( PubMed, DOI )
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Signaling Pathways Potentially Responsible for Foam Cell Formation: Cholesterol Accumulation or Inflammatory Response-What is First? 2020.04; 21 (8): 2716. ( PubMed, DOI )
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Ultrasound modulates fluorescence strength and ABCG2 mRNA response to aminolevulinic acid in glioma cells. 2020.03; 87 (6): 310-317. ( PubMed, DOI )
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Role of Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a Transcriptome Analysis. 2020.01; 21 (3): 817. ( PubMed, DOI )
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Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity. 2020; 7 64. ( PubMed, DOI )
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Oishi Yumiko, Manabe Ichiro. 炎症、修復、再生におけるマクロファージ(Macrophages in inflammation, repair and regeneration) International Immunology. 2018.11; 30 (11): 511-528. ( ichushi )
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Macrophages in inflammation, repair and regeneration. 2018.10; 30 (11): 511-528. ( PubMed, DOI )
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In vitro and in silico studies of the molecular interactions of epigallocatechin-3-o-gallate (egcg) with proteins that explain the health benefits of green tea 2018; 23 (6): ( PubMed, DOI )
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Oishi Y, Manabe I. Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease. Frontiers in cardiovascular medicine. 2018; 5 69. ( PubMed, DOI )
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Sumio Hayakawa, Kieko Saito, Noriyuki Miyoshi, Tomokazu Ohishi, Yumiko Oishi, Mamoru Miyoshi, Yoriyuki Nakamura. Anti-Cancer Effects of Green Tea by Either Anti- or Pro- Oxidative Mechanisms. Asian Pac. J. Cancer Prev.. 2016.03; 17 (4): 1649-1654. ( PubMed )
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Yumiko Oishi, Ichiro Manabe. Immunometabolic control of homeostasis and inflammation Inflammation and Regeneration. 2015.09; 35 (4): 185-192.
Conference Activities & Talks 【 display / non-display 】
Conference Activities & Talks 【 display / non-display 】
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Cheng Yinglan, Koike Hiroyuki, Sakai Mashito, Oishi Yumiko. マクロファージにおけるTmem189欠損は肝細胞の脂肪滴蓄積様表現型を増大する(Tmem189 Deletion in Macrophages Increased a Hepatocyte Lipid Droplet Accumulation-like Phenotype). 日本医科大学医学会雑誌 2024.02.01
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Matsuda Shigeru, Kuwabara Yoshimitsu, Sugita Yosuke, Oishi Yumiko, Suzuki Shunji. 慢性子宮内膜炎に対する多価不飽和脂肪酸の影響 脂質代謝制御を改変したマウスモデルからの新たな知見(Impact of Polyunsaturated Fatty Acids on Chronic Endometritis: Novel Insights from a Mouse Model with Modified Lipid Metabolism Regulation). 日本産科婦人科学会雑誌 2024.02.01
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Oishi Yumiko. 健康と疾病における多様な免疫代謝コミュニケーション 日米免疫学プログラム共催セッション 筋肉の修復と再生を制御するマクロファージの新規サブセットの同定(Diverse immunometabolic communication in health and disease: US-Japan Immunology Program Co-organized Session Identification of a novel subset of macrophage that regulate muscle repair and regeneration). 日本免疫学会総会・学術集会記録 2023.12.01
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成 英瀾, 眞鍋 一郎, 早川 清雄, 遠藤 裕介, 大石 由美子. 炎症性カスパーゼ11は、マクロファージの炎症応答において、site-1プロテアーゼの切断とSREBP1の活性化に寄与する. 日本生化学会大会プログラム・講演要旨集 2023.10.01
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Cheng Yinglan, Hayakawa Sumio, Oishi Yumiko. 炎症性カスパーゼ-4はSIPを活性化しマクロファージにおけるSREBP-1の成熟を促進する(Inflammatory Caspase-4 Actives SIP to Promote SREBP-1 Maturation in Macrophage). 日本医科大学医学会雑誌 2022.08.01
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大石 由美子. アテローム性動脈硬化の新たな治療標的としての細胞性コレステロール代謝機構(Cellular Cholesterol Metabolism as a Novel Therapeutic Target of Atherosclerosis). 日本循環器学会学術集会抄録集 2022.03.01
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Oishi Yumiko, Koike Hiroyuki. 骨格筋再生を制御するマクロファージの多様性(Macrophage diversity that regulates skeletal muscle regeneration). 日本免疫学会総会・学術集会記録 2021.11.01
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Sugita Yosuke, Kuwabara Yoshimitsu, Oishi Yumiko, Takeshita Toshiyuki. 培養ヒト子宮頸部線維芽細胞において観察される子宮頸管熟化に伴うプロゲステロン反応性の変化(Progesterone responsiveness change associated with cervical ripening observed in cultured human cervical fibroblasts). The Journal of Obstetrics and Gynaecology Research 2021.08.01
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Cheng Yinglan, Hayakawa Sumio, Oishi Yumiko. マクロファージにおいてCaspase-11はS1P活性化を介してSREBP-1の成熟に関与する(Caspase-11 Involves in SREBP-1 Maturation via Activation of SIP in Macrophage). 日本医科大学医学会雑誌 2021.06.01
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Sugita Yosuke, Kuwabara Yoshimitsu, Oishi Yumiko, Takeshita Toshiyuki. 培養ヒト子宮頸部線維芽細胞において観察される子宮頸管熟化に伴うプロゲステロン反応性の変化(Progesterone responsiveness change associated with cervical ripening observed in cultured human cervical fibroblasts). 日本産科婦人科学会雑誌 2021.03.01
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大石 由美子. 多様性はどうやって私たちをより良く、より賢く、より幸せにするか(How Diversity Makes Us Better, Smarter and Happier?). 日本循環器学会学術集会抄録集 2021.03.01
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成 英瀾, 早川 清雄, 大石 由美子. マクロファージにおける炎症性カスパーゼのコレステロール合成制御への関与(Participation of inflammatory caspase to regulate cholesterol synthesis in macrophage). 日本生化学会大会プログラム・講演要旨集 2019.09.01
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大石 由美子. マクロファージにおける炎症反応と脂質代謝の協調制御(Coordinated Regulation of Inflammatory Response and Lipid Metabolism in Macrophages). 日本循環器学会学術集会抄録集 2019.03.01
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成 英瀾, 早川 清雄, 大石 由美子. マクロファージにおける炎症性カスパーゼによる脂質代謝の調節(Regulation of lipid metabolism by inflammatory caspase in macrophage). 日本生化学会大会プログラム・講演要旨集 2018.09.01
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Oishi Yumiko. メタボリックシンドロームの新規治療標的としての炎症反応、脂質代謝、概日リズムの協調制御(Coordinated Regulation of Inflammatory Response, Lipid Metabolism and Circadian Rhythm as a Novel Therapeutic Target of Metabolic Syndrome). 日本循環器学会学術集会抄録集 2018.03.01
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Oishi Yumiko. 脂肪酸代謝のリプログラミングは炎症の消散に不可欠である(Reprogramming of fatty acid metabolism is crucial for the inflammatory resolution). The Journal of Physiological Sciences 2018.03.01
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劉 琳, 林 晋一郎, 大石 由美子. Klf5は筋萎縮症の病態形成に関与している(Klf5 is involved in the pathogenesis of muscle atrophy). 生命科学系学会合同年次大会 2017.12.01
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Yumiko Oishi. Coordinated regulation of inflammatory response and fatty acid metabolism in macrophage. Transborder medical research center international symposium, Tsukuba University 2017.06.17 Tsukuba, Japan
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Yumiko Oishi. SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism.. 11th International Symposium of the Institute Network 2017.01.26 Tokushima, Japan