Personnel Information

写真a

KOBAYAKAWA Takuya


Job title

Assistant Professor

Laboratory Address

2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan

Laboratory Phone number

+81-3-5280-8039

Laboratory Fax number

+81-3-5280-8039

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/i-mde/www/en/biomolecular/index1.html

Research Areas, Keywords

Synthetic Organic Chemistry, Medicinal Chemistry, Chemical Biology, Peptide Chemistry, Peptidomimetic Chemistry

Graduating School 【 display / non-display

  • Waseda University, School of Advance Science and Engineering, Department of Applied Chemistry, 2012.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology Track, Master's Course, 2014.03, Completed

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology Track, Doctor's Course, 2017.03, Completed

Degree 【 display / non-display

  • Doctor (Engineering), Tokyo Medical and Dental University

  • Master (Engineering), Tokyo Medical and Dental University

  • Bachelor (Engineering), Waseda University

Campus Career 【 display / non-display

  • 2012.04
    -
    2014.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology, Graduate Student
  • 2014.04
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Medicinal Chemistry, Graduate Student
  • 2017.04
    -
    2017.09
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Medicinal Chemistry, Junior Associate Professor
  • 2017.10
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Medicinal Chemistry, Assistant Professor

External Career 【 display / non-display

  • 2014.04
    -
    2016.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Research Assistant
  • 2015.04
    -
    2016.03
    Tokyo Kasei University,
  • 2016.04
    -
    2017.03
    Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, Research Fellowships for Young Scientists
  • 2017.04
    -
    2017.09
    Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, Research Fellowships for Young Scientists

Academic Society Affiliations 【 display / non-display

  • The Pharmaceutical Society of Japan

  • Japanese Society for Chemical Biology

  • The Society of Synthetic Organic Chemistry, Japan

  • The Japanese Peptide Society

  • American Chemical Society

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Academic Activity 【 display / non-display

  • 2013.06
     
     
    The 8th Annual Meeting of Japanese Society for Chemical Biology The 8th Annual Meeting of Japanese Society for Chemical Biology, Cooperation Staff
  • 2017.10
    -
    Now
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Open Campus Committee
  • 2018.06
     
     
    The 13th Annual Meeting of Japanese Society for Chemical Biology The 13th Annual Meeting of Japanese Society for Chemical Biology, Cooperation Staff

Research Areas 【 display / non-display

  • Chemical pharmacy

  • Organic chemistry

  • Synthetic chemistry

  • Drug development chemistry

  • Chemical biology

Qualification Acquired 【 display / non-display

  • Hazardous Material Handler (first kind)

  • Usual Car License (first kind)

 

Published Papers & Misc 【 display / non-display

  • Kobayakawa T, Azuma C, Watanabe Y, Sawamura S, Taniguchi A, Hayashi Y, Tsuji K, Tamamura H. Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. The Journal of organic chemistry. 2021.04; 86 (7): 5091-5101. ( PubMed, DOI )

  • Kobayakawa T, Yokoyama M, Tsuji K, Fujino M, Kurakami M, Boku S, Nakayama M, Kaneko M, Ohashi N, Kotani O, Murakami T, Sato H, Tamamura H. Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins. Biomolecules. 2021.02; 11 (2): ( PubMed, DOI )

  • Kobayakawa T, Tsuji K, Konno K, Himeno A, Masuda A, Yang T, Takahashi K, Ishida Y, Ohashi N, Kuwata T, Matsumoto K, Yoshimura K, Sakawaki H, Miura T, Harada S, Matsushita S, Tamamura H. Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of medicinal chemistry. 2021.01; ( PubMed, DOI )

  • Matsuda K, Kobayakawa T, Kariya R, Tsuchiya K, Ryu S, Tsuji K, Ishii T, Gatanaga H, Yoshimura K, Okada S, Hamada A, Mitsuya H, Tamamura H, Maeda K. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in microbiology. 2021; 12 636276. ( PubMed, DOI )

  • Kobayakawa Takuya, Ebihara Kento, Tsuji Kohei, Kawada Takuma, Fujino Masayuki, Honda Yuzuna, Ohashi Nami, Murakami Tsutomu, Tamamura Hirokazu. Bivalent HIV-1 fusion inhibitors based on peptidomimetics BIOORGANIC & MEDICINAL CHEMISTRY. 2020.12; 28 (24): 115812. ( PubMed, DOI )

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Books etc 【 display / non-display

  • The Frontier of Peptide Drug Discovery. 2019.05 (ISBN : 978-4-7813-1417-4)

  • Synthesis Technology of Peptides, Nucleic Acids and Sugar Chains for Medium Molecule Drug Discovery. CMC Publishing Co.,Ltd., 2018.02 (ISBN : 978-4-7813-1320-7)

  • Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi. Mid-size Drugs Based on Peptides and Peptidomimetics. Springer Singapore, 2018.01 (ISBN : 978-981-10-7691-6)

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Stereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. The Japanese Peptide Society, 2016.03

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. The Japanese Peptide Society, 2015.03

Conference Activities & Talks 【 display / non-display

  • Kofi Baffour-Awuah Owusu, Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Moemi Kaneko, Tsutomu Murakami, Hirokazu Tamamura. Exploratory studies on the development of anti-HIV-1 peptides based on HIV-1 capsid fragments. 第57回ペプチド討論会 2020.11.10 online

  • Wataru Nomura, Takumi Kamimura, Takuya Kobayakawa, Hirokazu Tamamura. Endogenous protein expression imaging by fluorogenic ZIP tag-probe system. 第57回ペプチド討論会 2020.11.10 online

  • Chika Azuma, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura. A convergent synthesis of chloroalkene dipeptide isosteres as peptidomimetics. 第57回ペプチド討論会 2020.11.09 online

  • Tsutomu Murakami, Kento Ebihara, Takuya Kobayakawa, Masayuki Fujino, Eiichi Kodama, Hirokazu Tamamura. Elucidation of mechanism of HIV-1 fusion inhibitors developed by dimerization strategy. The 67th Annual Meeting of the Japanese Society for Virology 2019.10.29 Tokyo

  • Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-ichiro Hattori, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya, Kenji Maeda. Benzolactam protein kinase C activators promote apoptosis of HIV-infected human cells via HIV latency reversal. The 67th Annual Meeting of the Japanese Society for Virology 2019.10.29 Tokyo

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Campus class subject 【 display / non-display

  • Practical Chemical Biology,2018 - Now

  • Introduction to Chemistry and Biology of Biofunctional Molecules,2018 - Now

  • Development of Functional Molecules,2018 - Now

External class subject 【 display / non-display

  • ,Tokyo Kasei University

  • ,Tokyo Kasei University

Performance of duties 【 display / non-display

  • ,2020.01

  • ,2019.01

  • ,2019.01

  • ,2019.01

  • ,2018.08

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Social Contribution 【 display / non-display

  • Frontier Research on Medicinal Chemistry of Mid-sized Molecules,Kanazawa, Japan,2018.03.28