Personnel Information

写真a

KIMURA Naoki


Job title

Junior Associate Professor

Research Areas, Keywords

polymyositis/dermatomyositis
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2006.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2014.03, Completed

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Campus Career 【 display / non-display 】

  • 2014.04
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    2017.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Assistant Professor
  • 2014.04
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    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2017.04
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    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2018.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2021.04
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    2023.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Endowed Departments， Department of Lifetime Clinical Immunology， Junior Associate Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Rheumatology， Junior Associate Professor

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Academic Society Affiliations 【 display / non-display 】

  • Japanese Society for Immunology

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Research Areas 【 display / non-display 】

  • Connective tissue disease and allergy

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. Baba H, Kimura N, Kanegane H, Miya F, Kosaki K, Morio T, Koike R. GATA2 deficiency of a novel missense variant with multiorgan inflammation. Rheumatology (Oxford, England). 2024.01; ( PubMed, DOI )

  2. Miyamoto T, Izawa K, Masui S, Yamazaki A, Yamasaki Y, Matsubayashi T, Shiraki M, Ohnishi H, Yasumura J, Tomohiro K, Miyamae T, Matsubara T, Arakawa N, Ishige T, Takizawa T, Shimbo A, Shimizu M, Kimura N, Maeda Y, Maruyama Y, Shigemura T, Furuta J, Sato S, Tanaka H, Izumikawa M, Yamamura M, Hasegawa T, Kaneko H, Nakagishi Y, Nakano N, Iida Y, Nakamura T, Wakiguchi H, Hoshina T, Kawai T, Murakami K, Akizuki S, Morinobu A, Ohmura K, Eguchi K, Sonoda M, Ishimura M, Furuno K, Kashiwado M, Mori M, Kawahata K, Hayama K, Shimoyama K, Sasaki N, Ito T, Umebayashi H, Omori T, Nakamichi S, Dohmoto T, Hasegawa Y, Kawashima H, Watanabe S, Taguchi Y, Nakaseko H, Iwata N, Kohno H, Ando T, Ito Y, Kataoka Y, Saeki T, Kaneko U, Murase A, Hattori S, Nozawa T, Nishimura K, Nakano R, Watanabe M, Yashiro M, Nakamura T, Komai T, Kato K, Honda Y, Hiejima E, Yonezawa A, Bessho K, Okada S, Ohara O, Takita J, Yasumi T, Nishikomori R, Japan CAPS working group. Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey. Arthritis & rheumatology (Hoboken, N.J.). 2024.01; ( PubMed, DOI )

  3. Komiya Yoji, Sugihara Takahiko, Hirano Fumio, Matsumoto Takumi, Kamiya Mari, Sasaki Hirokazu, Hosoya Tadashi, Kimura Naoki, Ishizaki Tatsuro, Mori Masaaki, Tohma Shigeto, Yasuda Shinsuke, Matsui Toshihiro. Factors associated with impaired physical function in elderly rheumatoid arthritis patients who had achieved low disease activity(タイトル和訳中) Modern Rheumatology. 2024.01; 34 (1): 60-67. ( ichushi )

  4. Kamiya Mari, Kimura Naoki, Umezawa Natsuka, Hasegawa Hisanori, Yasuda Shinsuke. Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy FRONTIERS IN IMMUNOLOGY. 2023.07; 14 1191815. ( PubMed, DOI )

  5. Itakura Takuji, Sasaki Hirokazu, Hosoya Tadashi, Yamaguchi Taiki, Mimori Erika, Saimon Yukino, Iwai Hideyuki, Umezawa Natsuka, Kawata Daisuke, Kimura Naoki, Kurata Morito, Shimizu Masaki, Yasuda Shinsuke. A novel gain-of-function missense variant in PLCG2 associated with autoinflammation and hypergammaglobulinaemia RHEUMATOLOGY. 2023.04; 62 (11): e319-e321. ( PubMed, DOI )

  6. Umezawa N, Mizoguchi F, Maejima Y, Kimura N, Hasegawa H, Hosoya T, Fujimoto M, Kohsaka H, Naka T, Yasuda S. Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides. Frontiers in medicine. 2023; 10 1153883. ( PubMed, DOI )

  7. Komiya Yoji, Sugihara Takahiko, Hirano Fumio, Matsumoto Takumi, Kamiya Mari, Sasaki Hirokazu, Hosoya Tadashi, Kimura Naoki, Ishizaki Tatsuro, Mori Masaaki, Tohma Shigeto, Yasuda Shinsuke, Matsui Toshihiro. Factors associated with impaired physical function in elderly rheumatoid arthritis patients who had achieved low disease activity MODERN RHEUMATOLOGY. 2022.12; 34 (1): 60-67. ( PubMed, DOI )

  8. Nishijima Hitoshi, Sugita Mizuki, Umezawa Natsuka, Kimura Naoki, Sasaki Hirokazu, Kawano Hiroshi, Nishioka Yasuhiko, Matsumoto Minoru, Oya Takeshi, Tsuneyama Koichi, Morimoto Junko, Matsumoto Mitsuru. Development of organ-specific autoimmunity by dysregulated Aire expression IMMUNOLOGY AND CELL BIOLOGY. 2022.05; 100 (5): 371-377. ( PubMed, DOI )

  9. Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori, Shinsuke Yasuda. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. Arthritis Res Ther. 2022.04; 24 (1): 92. ( PubMed, DOI )

  10. Kimura Naoki, Kawahara Takuya, Uemura Yukari, Atsumi Tatsuya, Sumida Takayuki, Mimura Toshihide, Kawaguchi Yasushi, Amano Hirofumi, Iwasaki Yukiko, Kaneko Yuko, Matsui Toshihiro, Muro Yoshinao, Imura Yoshitaka, Kanda Takashi, Tanaka Yoshiya, Kawakami Atsushi, Jinnin Masatoshi, Ishii Tomonori, Hiromura Keiju, Miwa Yusuke, Nakajima Hiroshi, Kuwana Masataka, Nishioka Yasuhiko, Morinobu Akio, Kameda Hideto, Kohsaka Hitoshi. Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-centre, randomized controlled trial RHEUMATOLOGY. 2022.02; 61 (11): 4445-4454. ( PubMed, DOI )

  11. 星合 愛子, 楠本 康香, 星合 泰治, 木村 直樹, 伊藤 由希子, 吉田 直美, 篠塚 修, 岩本 勉. 関節リウマチ患者の口腔衛生管理に影響を及ぼす要因の検討(Factors Influencing Oral Hygiene Management in Patients with Rheumatoid Arthritis) 障害者歯科. 2022.02; 43 (1): 7-16. ( ichushi )

  12. Noda S, Honda S, Hirota Y, Ito T, Hasegawa H, Kimura N, Matsuo Y, Iwai H, Kohsaka H, Yasuda S. Azathioprine Monotherapy for the Cases of Immunoglobulin G4-Related Disease With Contraindications to Glucocorticoids. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2021.02; 27 (8S): S327-S330. ( PubMed, DOI )

  13. Kamiya M, Mizoguchi F, Takamura A, Kimura N, Kawahata K, Kohsaka H. A new in vitro model of polymyositis reveals CD8+ T cell invasion into muscle cells and its cytotoxic role. Rheumatology (Oxford, England). 2019.06; ( PubMed, DOI )

  14. Umezawa Natsuka, Kawahata Kimito, Mizoguchi Fumitaka, Kimura Naoki, Yoshihashi-Nakazato Yoko, Miyasaka Nobuyuki, Kohsaka Hitoshi. Interleukin-23 as a therapeutic target for inflammatory myopathy SCIENTIFIC REPORTS. 2018.04; 8 (1): 5498. ( PubMed, DOI )

  15. Hideto Takada, Naoki Kimura, Yoko Yoshihashi-Nakazato, Kimito Kawahata, Hitoshi Kohsaka. Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. Intern. Med.. 2017.07; 56 (12): 1581-1583. ( PubMed, DOI )

  16. Takada Hideto, Kimura Naoki, Yoshihashi-Nakazato Yoko, Kawahata Kimito, Kohsaka Hitoshi. 妊娠誘発性血球貪食症候群を合併した円板状エリテマトーデス(Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome) Internal Medicine. 2017.06; 56 (12): 1581-1583. ( ichushi )

  17. Yoko Yoshihashi-Nakazato, Kimito Kawahata, Naoki Kimura, Nobuyuki Miyasaka, Hitoshi Kohsaka. Interferon-γ, but Not Interleukin-4, Suppresses Experimental Polymyositis. Arthritis & rheumatology (Hoboken, N.J.). 2016.06; 68 (6): 1505-1510. ( PubMed, DOI )

  18. H Takada, T Hosoya, N Kimura, K Kawahata, H Kohsaka. Successful use of rituximab in a patient with refractory thrombotic thrombocytopaenic purpura complicated by polymyositis. Scand. J. Rheumatol.. 2016.06; 1-2. ( PubMed, DOI )

  19. Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka. Injury and subsequent regeneration of muscles for activation of local innate immunity to facilitate the development and relapse of autoimmune myositis in C57BL/6 mice. Arthritis & rheumatology (Hoboken, N.J.). 2015.04; 67 (4): 1107-1116. ( PubMed, DOI )

  20. Naoki Kimura, Kazuki Takada, Kiyoshi Murata, Hitoshi Kohsaka, Nobuyuki Miyasaka. A case of Behçet’s disease complicated by carotid-oesophageal fistula. Rheumatology (Oxford). 2014.01; 53 (1): 196-198. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Naoki Kimura, Hitoshi Kohsaka. Branched chain amino acids in the treatment of polymyositis and dermatomyositis：results from the BTOUGH study.. Annual European Congress of Rheumatology 2019 (EULAR 2019) 2019.06.14 Madrid, Spain

  2. Naoki Kimura, Kimito Kawahata, Hitoshi Kohsaka. Peripheral license for autoimmune-mediated tissue injury revealed from a murine model of polymyositis. The 44th Annual Meeting of the Japanese Society for Immunology 2015.11.20 Sapporo, Japan

  3. Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka. Injury and Subsequent Regeneration of Muscles Activate Local Innate Immunity to Facilitate Development and Relapse of Autoimmune Myositis. First International Conference on MYOSITIS 2015.05.08

  4. Yoko Yoshihashi-Nakazato, Kimito Kawahata, Naoki Kimura, Hitoshi Kohsaka.. Interferon-gamma but not interleukin-4 restrains experimental myositis. . 1st International Conference on Myositis 2015.05.08 Stockholm, Sweden

  5. Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka.. Injury And Subsequent Regeneration Of Muscles Activate Local Innate Immunity To Facilitate Development And Relapse Of Autoimmune Myositis.. 1st International Conference on Myositis 2015.05.08 Stockholm, Sweden

  6. Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka. Injury and subsequent regeneration of muscles activate local innate immunity to facilitate development and relapse of autoimmune myositis. The 59th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2015.04.24 Nagoya, Japan

  7. Naoki Kimura, Shinya Hirata, Nobuyuki Miyasaka, Kimito Kawahata, Hitoshi Kohsaka.. Injury and subsequent regeneration of muscles activate local innate immunity to facilitate development and relapse of autoimmune myositis. 第59回日本リウマチ学会総会・学術集会 2015.04.23 名古屋

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