Personnel Information

写真a

HIRATE Yoshikazu


Job title

Junior Associate Professor

Homepage URL

http://www.tmd-cea.jp/eam/en/

Research Areas, Keywords

Developmental biology, Developmental Engineering, Reproductive biology
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Campus Career 【 display / non-display 】

  • 2014.10
    -
    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Experimental Animal， Junior Associate Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Experimental Animal Model for Human Disease， Junior Associate Professor
  • 2014.04
    -
    2014.09
    Tokyo Medical and Dental University， Joint Institutes for Education and Research， Center for Experimental Animal， Junior Associate Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Junior Associate Professor
  • 2017.05
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Junior Associate Professor
  • 2020.10
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Junior Associate Professor

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External Career 【 display / non-display 】

  • 2006.01
    -
    2009.03
    Fred Hutchinson Cancer Research Center, Postdoctoral Research Fellow
  • 2011.04
    -
    2014.03
    , Assistant Professor
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Research Areas 【 display / non-display 】

  • Developmental biology

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Published Papers & Misc 【 display / non-display 】

  1. Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M, Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A, Kanai-Azuma M, Kudo A, Kanai Y. SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse. Nature communications. 2022.12; 13 (1): 7860. ( PubMed, DOI )

  2. Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, Hirate Y, Akimoto Y, Komada M, Kanai Y, Miyasaka N, Kanai-Azuma M. A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas. The Journal of reproduction and development. 2022.12; 69 (1): 32-40. ( PubMed, DOI )

  3. Hirate Yoshikazu, Hayakawa Kana, Nakano Yuki, Kumazawa Shiori, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. Role of SOX17 in crypt formation and regulation of SOX9 and AREG expression at the implantation site(和訳中) Experimental Animals. 2021.06; 70 (Suppl.): S61. ( ichushi )

  4. Hirate Yoshikazu, Hayakawa Kana, Nakano Yuki, Kumazawa Shiori, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. Early Crypt Formation Defects in the Uterine Epithelia of Sox17 Heterozygous Mice SEXUAL DEVELOPMENT. 2021.03; 140 (1-6): 1-11. ( PubMed, DOI )

  5. Imura-Kishi Kasane, Uchida Aya, Tsunekawa Naoki, Suzuki Hitomi, Takase Hinako M., Hirate Yoshikazu, Kanai-Azuma Masami, Hiramatsu Ryuji, Kurohmaru Masamichi, Kanai Yoshiakira. Low retinoic acid levels mediate regionalization of the Sertoli valve in the terminal segment of mouse seminiferous tubules SCIENTIFIC REPORTS. 2021.01; 11 (1): 1110. ( PubMed, DOI )

  6. Pattarapanawan M, Uemura M, Miyazaki N, Takami S, Tomiyasu H, Tsunekawa N, Hirate Y, Fujishiro J, Kurohmaru M, Kanai-Azuma M, Higashiyama H, Kanai Y. Anatomical and histological characteristics of the hepatobiliary system in adult Sox17 heterozygote mice. Anatomical record (Hoboken, N.J. : 2007). 2020.06; 303 (12): 3096-3107. ( PubMed, DOI )

  7. Yamada Takahiko, Takechi Masaki, Yokoyama Norisuke, Hiraoka Yuichi, Ishikubo Harumi, Usami Takako, Furutera Toshiko, Taga Yuki, Hirate Yoshikazu, Kanai-Azuma Masami, Yoda Tetsuya, Ogawa-Goto Kiyoko, Iseki Sachiko. Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse DEVELOPMENTAL DYNAMICS. 2020.01; 249 (5): 622-635. ( PubMed, DOI )

  8. Takahashi Hitomi, Hirate Yoshikazu, Li Jinling, Ito Yoshiaki, Otsuka Chiho, Anezaki Mayumi, Asahara Hirosh, Chen-Tsai Ruby Yanru, Kanai-Azuma Masami. 試験管内授精マウス胚におけるTARGATTノックインシステムを用いた部位特異的遺伝子導入(Site-specific transgenesis using TARGATT knock-in system in in vitro fertilized mouse embryos) Experimental Animals. 2019.07; 68 (Suppl.): S219. ( ichushi )

  9. Hirate Yoshikazu, Nakano Yuki, Yoshida Tatsumi, Ito Hikaru, Uemura Mami, Kanai Yoshiakira, Kanai-Azuma Masami. 子宮内膜上皮移植に対する、TRECKに基づいたアプローチ法の確立(Establishment of a TRECK-based approach for replacement of uterine endometrial epithelium) Experimental Animals. 2019.07; 68 (Suppl.): S66. ( ichushi )

  10. Miura Kento, Harikae Kyoko, Nakaguchi Mayu, Imaimatsu Kenya, Hiramatsu Ryuji, Tomita Ayako, Hirate Yoshikazu, Kanai-Azuma Masami, Kurohmaru Masamichi, Ogura Atsuo, Kanai Yoshiakira. Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice PLOS ONE. 2019.03; 14 (3): e0212367. ( PubMed, DOI )

  11. Hitomi Igarashi, Mami Uemura, Ryuji Hiramatsu, Ryuto Hiramatsu, Saki Segami, Montri Pattarapanawan, Yoshikazu Hirate, Yuki Yoshimura, Haruo Hashimoto, Hiroki Higashiyama, Hiroyuki Sumitomo, Masamichi Kurohmaru, Yukio Saijoh, Hiroshi Suemizu, Masami Kanai-Azuma, Yoshiakira Kanai. Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk. Biology of Reproduction. 2018.04; 99 (3): 578-589. ( PubMed, DOI )

  12. Hirate Yoshikazu, Hayakawa Kana, Toyomura Yuga, Igarashi Hitomi, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. Sox17ハプロ不全による着床異常マウスにおける子宮上皮遺伝子の発現変化(Expression changes in uterine epithelial genes in implantation-defective mice due to Sox17 haploinsufficiency) Experimental Animals. 2017.06; 66 (Suppl.): S101. ( ichushi )

  13. Hiroki Higashiyama, Aisa Ozawa, Hiroyuki Sumitomo, Mami Uemura, Ko Fujino, Hitomi Igarashi, Kenya Imaimatsu, Naoki Tsunekawa, Yoshikazu Hirate, Masamichi Kurohmaru, Yukio Saijoh, Masami Kanai-Azuma, Yoshiakira Kanai. Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017.05; 144 (10): 1906-1917. ( PubMed, DOI )

  14. Yusuke Watanabe, Kota Y Miyasaka, Atsushi Kubo, Yasuyuki S Kida, Osamu Nakagawa, Yoshikazu Hirate, Hiroshi Sasaki, Toshihiko Ogura. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Scientific Reports. 2017.04; 7 46135. ( PubMed, DOI )

  15. Yoshikazu Hirate, Hitomi Suzuki, Miyuri Kawasumi, Hinako M Takase, Hitomi Igarashi, Philippe Naquet, Yoshiakira Kanai, Masami Kanai-Azuma. Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. Scientific Reports. 2016.04; 6 24171. ( PubMed, DOI )

  16. Hirate Y, Hirahara S, Inoue K, Kiyonari H, Niwa H, Sasaki H.. Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos. Development, Growth & Differentiation. 2015.10; 57 (8): 544-556. ( PubMed, DOI )

  17. Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A.. HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLOS Genetics. 2014.10; 10 (10): e1004618. ( PubMed, DOI )

  18. Hirate Yoshikazu, Sasaki Hiroshi. The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers. 2014.01; 2 (1): e28127. ( PubMed, DOI )

  19. Hirate Yoshikazu, Hirahara Shino, Inoue Ken-Ichi, Suzuki Atsushi, Alarcon Vernadeth B, Akimoto Kazunori, Hirai Takaaki, Hara Takeshi, Adachi Makoto, Chida Kazuhiro, Ohno Shigeo, Marikawa Yusuke, Nakao Kazuki, Shimono Akihiko, Sasaki Hiroshi. Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013.07; 23 (13): 1181-1194. ( PubMed, DOI )

  20. Hirate Yoshikazu, Cockburn Katie, Rossant Janet, Sasaki Hiroshi. Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos. Proc Natl Acad Sci U S A. 2012.12; 109 (50): E3389-90; author reply E3391. ( PubMed, DOI )

  21. Matsui Takaaki, Thitamadee Siripong, Murata Tomoko, Kakinuma Hisaya, Nabetani Takuji, Hirabayashi Yoshio, Hirate Yoshikazu, Okamoto Hitoshi, Bessho Yasumasa. Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis. Proc Natl Acad Sci U S A. 2011.06; 108 (24): 9881-9886. ( PubMed, DOI )

  22. Rutherford Suzannah, Hirate Yoshikazu, Swalla Billie J. The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis. Crit Rev Biochem Mol Biol. 2007.09; 42 (5): 355-372. ( PubMed, DOI )

  23. Hirate Yoshikazu, Okamoto Hitoshi. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. Curr Biol. 2006.02; 16 (4): 421-427. ( PubMed, DOI )

  24. Miyashita Toshio, Yeo Sang-Yeob, Hirate Yoshikazu, Segawa Hiroshi, Wada Hironori, Little Melissa H, Yamada Toshiya, Takahashi Naoki, Okamoto Hitoshi. PlexinA4 is necessary as a downstream target of Islet2 to mediate Slit signaling for promotion of sensory axon branching. Development. 2004.08; 131 (15): 3705-3715. ( PubMed, DOI )

  25. Okamoto Hitoshi, Hirate Yoshikazu, Ando Hideki. Systematic identification of factors in zebrafish regulating the early midbrain and cerebellar development by odered differential display and caged mRNA technology. Front Biosci. 2004.01; 9 93-99. ( PubMed )

  26. Hirate Yoshikazu, Okamoto Hitoshi, Yamasu Kyo. Structure of the zebrafish fasciclin I-related extracellular matrix protein (betaig-h3) and its characteristic expression during embryogenesis. Gene Expr Patterns. 2003.06; 3 (3): 331-336. ( PubMed )

  27. Y Hirate, M Mieda, T Harada, K Yamasu, H Okamoto. Identification of ephrin-A3 and novel genes specific to the midbrain-MHB in embryonic zebrafish by ordered differential display. Mech. Dev.. 2001.09; 107 (1-2): 83-96. ( PubMed )

  28. H Segawa, T Miyashita, Y Hirate, S Higashijima, N Chino, K Uyemura, Y Kikuchi, H Okamoto. Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Neuron. 2001.05; 30 (2): 423-436. ( PubMed )

  29. Y Hirate, K Tomita, S Yamamoto, K Kobari, I Uemura, K Yamasu, T Suyemitsu. Association of the sea urchin EGF-related peptide, EGIP-D, with fasciclin I-related ECM proteins from the sea urchin Anthocidaris crassispina. Dev. Growth Differ.. 1999.08; 41 (4): 483-494. ( PubMed )

  30. Y Fujita, Y Hirate, T Hiyama, K Yamasu, T Suyemitsu, K Ishihara. Purification of EGIP-D-binding protein from the embryos of the sea urchin Anthocidaris crassispina. Zool. Sci.. 1997.12; 14 (6): 931-934. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. 山田竜一、小栗晶、藤木克則、白髭克彦、平手良和、金井正美、竹添裕高、秋元義弘、高橋直樹. 頭部外胚葉におけるレンズ誘導におけるMab21l1の機能. 第44回日本分子生物学会年会 2021.12.01 パシフィコ横浜

  2. Hirate Yoshikazu, Hayakawa Kana, Nakano Yuki, Kumazawa Shiori, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. 陰窩形成におけるSOX17の役割と着床部位におけるSOX9及びAREG発現の制御(Role of SOX17 in crypt formation and regulation of SOX9 and AREG expression at the implantation site). Experimental Animals 2021.06.01

  3. 山田竜一、小栗晶、藤木克則、白髭克彦、平手良和、金井正美、竹添裕高、金井克晃、高橋直樹. Mab21l1欠損マウスレンズ前駆細胞の1細胞解析. 第43回日本分子生物学会 2020.12.02 Web開催

  4. Yoshikazu Hirate, Hitomi Takahashi, Yoshiaki Ito, Jinling Li, Chiho Otsuka, Hiroshi Asahara, Ruby Yanru Chen-Tsai, Masami Kanai-Azuma. Site-directed transgenic mice production using TARGATT™ knock-in technology in TMDU. The 15th Transgenic Technology Meeting (TT2019) 2019.04.08 Kobe, Hyogo, Japan

  5. Hirate Yoshikazu, Hayakawa Kana, Nakano Yuki, Uemura Mami, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. 着床前後における子宮SOX17の下流遺伝子の同定(Identification of downstream genes of the uterine SOX17 around the receptive period). Experimental Animals 2018.07.01

  6. Hirate Y, Kanai Y, Kanai-Azuma M. Molecular pathways downstream of Sox17 in uterine epithelia during mouse implantation processes. Eighth International Symposium on Vertebrate Sex Determination 2018.04.16 Kona, Hawaii

  7. Yoshikazu Hirate, Kana Hayakawa, Yuga Toyomura, Hitomi Igarashi, Kento Miura, Yoshiakira Kanai, and Masami Kanai-Azuma. Sox17 heterozygous mutant females are defective in implantation. The 50th Annual Meeting of the Japanese Society of Developmental Biologists cosponsored by APDBN 2017.05.10 東京

  8. Kanai-Azuma Masami, Yoshikazu Hirate, Miyuri Kawasumi, Hitomi Suzuki, Yoshiakira Kanai. A possible involvement of a dose-dependent Sox17 activity of uterine epithelia in mouse implantation processes. 7th International Symposium Biology of Vertebrate Sex Determination 2015.04.13 Kona, Hawaii

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