Personnel Information

写真a

TSUJIMOTO Kazutaka


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2013.04
    -
    2017.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Graduate Student
  • 2017.04
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    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Assistant Professor
  • 2017.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Assistant Professor
  • 2019.11
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    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Assistant Professor
  • 2021.10
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    2022.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Diabetes, Endocrinology and Metabolism， Assistant Professor
  • 2022.04
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    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Molecular Endocrinology and Metabolism， Assistant Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Advanced Therapeutic Sciences， Department of Molecular Endocrinology and Metabolism， Assistant Professor

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Published Papers & Misc 【 display / non-display 】

  1. Daisuke Koga, Ryo Kaneda, Chikara Komiya, Satoshi Ohno, Akira Takeuchi, Kazunari Hara, Masato Horino, Jun Aoki, Rei Okazaki, Ryoko Ishii, Masanori Murakami, Kazutaka Tsujimoto, Kenji Ikeda, Hideki Katagiri, Hideyuki Shimizu, Tetsuya Yamada. Artificial intelligence identifies individuals with prediabetes using single-lead electrocardiograms. Cardiovasc Diabetol. 2025.11; 24 (1): 415. ( PubMed, DOI )

  2. Masato Horino, Kenji Ikeda, Rei Okazaki, Yujiro Nakano, Ryo Kaneda, Ryoko Ishii, Jun Aoki, Kazunari Hara, Akira Takeuchi, Yoshihiro Niitsu, Kuniyuki Taguchi, Kuniyuki Kano, Masanori Murakami, Kazutaka Tsujimoto, Chikara Komiya, Tetsuya Yamada. Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism. Sci Rep. 2025.08; 15 (1): 31922. ( PubMed, DOI )

  3. Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Kuniyuki Kano, Yoshihiro Niitsu, Masato Horino, Kazunari Hara, Rei Okazaki, Ryo Kaneda, Masanori Murakami, Kumiko Shiba, Chikara Komiya, Junken Aoki, Tetsuya Yamada. Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice. Nat Commun. 2025.07; 16 (1): 6072. ( PubMed, DOI )

  4. Hara K, Murakami M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Yamamoto K, Taguchi T, Akashi T, Yoshida S, Ohashi K, Fujii Y, Yamada T.. Unexpected Remission of Bilateral Hyperaldosteronism After Unilateral Cortisol-Producing Adenoma Resection: A Report of Two Cases. Case Rep Endocrinol.. 2025.06; 9941688 (1): 9941688. ( PubMed, DOI )

  5. Shigematsu Takaaki, Yamaguchi Yu, Watanabe Takeo, Tsujimoto Kazutaka, Sato Fuminori, Yamada Tetsuya, Tsujino Motoyoshi. COVID-19ワクチン接種後に新規発症した劇症1型糖尿病の1例(New-onset Fulminant Type 1 Diabetes Following COVID-19 Vaccination) Internal Medicine. 2025.06; 64 (11): 1691-1695. ( ichushi )

  6. Matsumoto Shunya, Ishikawa Yudai, Fukushima Hiroshi, Yamamoto Kouhei, Tsujimoto Kazutaka, Kimura Koichiro, Waseda Yuma, Tanaka Hajime, Yoshida Soichiro, Fujii Yasuhisa. 経尿道的膀胱腫瘍一塊切除術で膀胱傍神経節腫を完全切除することができた1例(A case of bladder paraganglioma completely resected by transurethral endoscopic en-bloc resection of bladder tumor) IJU Case Reports. 2025.03; 8 (2): 93-96. ( ichushi )

  7. Masanori Murakami, Kazunari Hara, Kenji Ikeda, Masato Horino, Rei Okazaki, Yoshihiro Niitsu, Akira Takeuchi, Jun Aoki, Kumiko Shiba, Kazutaka Tsujimoto, Chikara Komiya, Yuki Nakamura, Morito Kurata, Takumi Akashi, Yasuhisa Fujii, Tetsuya Yamada. Single-Nucleus Analysis Reveals Tumor Heterogeneity of Aldosterone-Producing Adenoma. Hypertension. 2024.02; 81 (2): 361-371. ( PubMed, DOI )

  8. Matsugi A, Nishishita S, Bando K, Kikuchi Y, Tsujimoto K, Tanabe Y, Yoshida N, Tanaka H, Douchi S, Honda T, Odagaki M, Nakano H, Okada Y, Mori N, Hosomi K. Excessive excitability of inhibitory cortical circuit and disturbance of ballistic targeting movement in degenerative cerebellar ataxia. Scientific reports. 2023.08; 13 (1): 13917. ( PubMed, DOI )

  9. Yoshihiro Niitsu, Chikara Komiya, Akira Takeuchi, Kazunari Hara, Masato Horino, Jun Aoki, Rei Okazaki, Masanori Murakami, Kazutaka Tsujimoto, Kenji Ikeda, Tetsuya Yamada. Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip. PLoS One. 2023; 18 (5): e0284989. ( PubMed, DOI )

  10. Yujiro Nakano, Masanori Murakami, Kazunari Hara, Tatsuya Fukuda, Masato Horino, Akira Takeuchi, Yoshihiro Niitsu, Kumiko Shiba, Kazutaka Tsujimoto, Chikara Komiya, Minato Yokoyama, Kenji Ikeda, Takanobu Yoshimoto, Yasuhisa Fujii, Tetsuya Yamada. Long-term effects of primary aldosteronism treatment on patients with primary aldosteronism and chronic kidney disease. Clin Endocrinol (Oxf). 2022.11; 98 (3): 323-331. ( PubMed, DOI )

  11. Kazunari Hara, Masanori Murakami, Yoshihiro Niitsu, Akira Takeuchi, Masato Horino, Kumiko Shiba, Kazutaka Tsujimoto, Chikara Komiya, Kenji Ikeda, Mika Tsuiki, Akiyo Tanabe, Toshihiro Tanaka, Minato Yokoyama, Yasuhisa Fujii, Mitsuhide Naruse, Tetsuya Yamada. Heterogeneous circulating miRNA profiles of PBMAH. Front Endocrinol (Lausanne). 2022; 13 1073328. ( PubMed, DOI )

  12. Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K. Author Correction: Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver. Scientific reports. 2021.06; 11 (1): 12184. ( PubMed, DOI )

  13. Kawahori, K; Kondo, Y; Yuan, XM; Kawasaki, Y; Hanzawa, N; Tsujimoto, K; Wada, F; Kohda, T; Ishigami, A; Yamada, T; Ogawa, Y; Hashimoto, K. Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver SCIENTIFIC REPORTS. 2020.12; 10 (1): 21228. ( PubMed, DOI )

  14. Nakano Y, Komiya C, Shimizu H, Mishima H, Shiba K, Tsujimoto K, Ikeda K, Kashimada K, Dateki S, Yoshiura KI, Ogawa Y, Yamada T. A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5. Endocrine journal. 2020.11; 67 (11): 1099-1105. ( PubMed, DOI )

  15. Nakano Yujiro, Komiya Chikara, Shimizu Hitomi, Mishima Hiroyuki, Shiba Kumiko, Tsujimoto Kazutaka, Ikeda Kenji, Kashimada Kenichi, Dateki Sumito, Yoshiura Koh-ichiro, Ogawa Yoshihiro, Yamada Tetsuya. ABCG5遺伝子に新規ヘテロ接合性バリアントを認めるエゼチミブ奏効の高コレステロール血症の1例(A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5) Endocrine Journal. 2020.11; 67 (11): 1099-1105. ( ichushi )

  16. Hanzawa, N; Hashimoto, K; Yuan, XM; Kawahori, K; Tsujimoto, K; Hamaguchi, M; Tanaka, T; Nagaoka, Y; Nishina, H; Morita, S; Hatada, I; Yamada, T; Ogawa, Y. Targeted DNA demethylation of the <i>Fgf21</i> promoter by CRISPR/dCas9-mediated epigenome editing SCIENTIFIC REPORTS. 2020.03; 10 (1): 5181. ( PubMed, DOI )

  17. Fukaishi Takahiro, Minami Isao, Masuda Seizaburo, Miyachi Yasutaka, Tsujimoto Kazutaka, Izumiyama Hajime, Hashimoto Koshi, Yoshida Masayuki, Takahashi Sayako, Kashimada Kenichi, Morio Tomohiro, Kosaki Kenjiro, Maezawa Yoshiro, Yokote Koutaro, Yoshimoto Takanobu, Yamada Tetsuya. レプチン補充療法および代謝・内分泌プロファイルの短期・長期モニタリングを施行された全身性脂肪萎縮症関連早老症の1例(A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles) Endocrine Journal. 2020.02; 67 (2): 211-218. ( ichushi )

  18. Nakano, Y; Komiya, C; Shimizu, H; Mishima, H; Shiba, K; Tsujimoto, K; Ikeda, K; Kashimada, K; Dateki, S; Yoshiura, K; Ogawa, Y; Yamada, T. A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in <i>ABCG5</i> ENDOCRINE JOURNAL. 2020; 67 (11): 1099-1105. ( PubMed )

  19. Fukaishi T, Minami I, Masuda S, Miyachi Y, Tsujimoto K, Izumiyama H, Hashimoto K, Yoshida M, Takahashi S, Kashimada K, Morio T, Kosaki K, Maezawa Y, Yokote K, Yoshimoto T, Yamada T. A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles. Endocrine journal. 2019.11; 67 (2): 211-218. ( PubMed, DOI )

  20. Fukuda T., Bouchi R., Asakawa M., Takeuchi T., Shiba K., Tsujimoto K., Komiya C., Yoshimoto T., Ogawa Y., Yamada T.. Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes DIABETIC MEDICINE. 2019.10; 37 (1): 105-113. ( PubMed, DOI )

  21. Nakagawa M, Sugihara K, Isobe K, Akasu M, Tsujimoto K, Itsui Y, Nakajima Y. A case of tracheal obstruction caused by reflux and aspiration of semi-solid nutrients via the nasogastric tube. International journal of surgery case reports. 2019; 65 217-220. ( PubMed, DOI )

  22. Fukuda Tatsuya, Bouchi Ryotaro, Takeuchi Takato, Tsujimoto Kazutaka, Minami Isao, Yoshimoto Takanobu, Ogawa Yoshihiro. Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes: a retrospective observational study CARDIOVASCULAR DIABETOLOGY. 2018.04; 17 (1): 55. ( PubMed, DOI )

  23. Kawahori Kenichi, Hashimoto Koshi, Yuan Xunmei, Tsujimoto Kazutaka, Hanzawa Nozomi, Hamaguchi Miho, Kase Saori, Fujita Kyota, Tagawa Kazuhiko, Okazawa Hitoshi, Nakajima Yasuyo, Shibusawa Nobuyuki, Yamada Masanobu, Ogawa Yoshihiro. Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring THYROID. 2018.03; 28 (3): 395-406. ( PubMed, DOI )

  24. Yuan Xunmei, Tsujimoto Kazutaka, Hashimoto Koshi, Kawahori Kenichi, Hanzawa Nozomi, Hamaguchi Miho, Seki Takami, Nawa Makiko, Ehara Tatsuya, Kitamura Yohei, Hatada Izuho, Konishi Morichika, Itoh Nobuyuki, Nakagawa Yoshimi, Shimano Hitoshi, Takai-Igarashi Takako, Kamei Yasutomi, Ogawa Yoshihiro. Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood NATURE COMMUNICATIONS. 2018.02; 9 (1): 636. ( PubMed, DOI )

  25. Hashimoto Koshi, Nishihara Eijun, Matsumoto Masako, Matsumoto Shunichi, Nakajima Yasuyo, Tsujimoto Kazutaka, Yamakage Hajime, Satoh-Asahara Noriko, Noh Jaeduk Yoshimura, Ito Koichi, Miyauchi Akira, Mori Masatomo, Yamada Masanobu, Ogawa Yoshihiro. Sialic Acid-Binding Immunoglobulin-Like Lectin1 as a Novel Predictive Biomarker for Relapse in Graves' Disease: A Multicenter Study THYROID. 2018.01; 28 (1): 50-59. ( PubMed, DOI )

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Others 【 display / non-display 】

  • Uncovering a female-specific mechanism for energy expenditure in brown adipose tissue，2025.09

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