Yoshioka Kotaro, Su Su Lei Mon , Jia Chunyan, Yamada Hiroki, Asami Yutaro, Tanaka Kie, Wenying Piao, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. CNSを標的としたオーバーハングヘテロ二2本鎖核酸を用いた新しいアンチセンスオリゴヌクレオチド治療(A novel antisense oligonucleotide therapy by overhanging heteroduplex oligonucleotide targeting CNS) 臨床神経学. 2019.11; 59 (Suppl.): S408. ( ichushi )

Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huijia, Miyata Haruka, Yoshida-Tanaka Kie, Sujino Yumiko, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Hara Rintaro Iwata, Nagata Tetsuya, Wada Takeshi, Obika Satoshi, Yokota Takanori. Highly efficient silencing of microRNA by heteroduplex oligonucleotides NUCLEIC ACIDS RESEARCH. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

Mon Su Su Lei, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. アンチセンスオリゴヌクレオチド二本鎖の新しい構造は脳室内経路を介した効果を改善する(A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route) 臨床神経学. 2018.12; 58 (Suppl.): S394. ( ichushi )

Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huija, Enomoto Seiya, Miyata Haruka, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新しい種類の二本鎖オリゴヌクレオチドはin vivoにおいてmicroRNAサイレンシングの効力を増強する(A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing) 臨床神経学. 2018.12; 58 (Suppl.): S234. ( ichushi )

Guo Huijia, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Miyata Haruka, Yoshida-Tanaka Kie, Nagata Tetsuya, Yokota Takanori. 脂質結合二重鎖アンチセンスオリゴヌクレオチドによるマイクロRNAのサイレンシングの効力(Efficacy of microRNA silencing by lipid-conjugated double-stranded antisense oligonucleotides) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 83-88. ( ichushi )

Yoshioka K., Kunieda T., Asami Y., Sujino Y., Tanaka K., Piao W., Kuwahara H., Nishina K., Nagata T., Yokota T.. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 140. ( DOI )

Asami Y, Yoshioka K, Nishina K, Nagata T, Yokota T. Drug delivery system of therapeutic oligonucleotides Drug Discoveries & Therapeutics. 2016.10; 10 (5): 256-262. ( PubMed, DOI )

Yoshioka K,Lei Mon S,Jia C,Yamada H,Asami Y,Tanaka K,Wenying P,Kuwahara H,Nishina K,Nagata T,Yokota T. A novel antisense oligonucleotide terapy by overhanging heteroduplex oligonucleotide targeting CNS. 第60回⽇本神経学会術大会 2019.05.23 大阪

Asami Y, Yoshioka K, Kunieda T, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Iwata Hara R, Nagata T, Obika S, Wada T, Yokota T. Efficient microRNA silencing in vivo by heteroduplex oligonucleotides.. 遺伝子・デリバリー研究会第19回シンポジウム 2019.05.08 千葉

Yoshioka K, Kunieda K, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Ito S, Nagata T, Yokota T. Overhanging heteroduplex oligonucleotides enable enhanced gene silencing by efficient delivery associated with transferrin. 14th Annual Meeting of the Oligonucleotide Therapeutics Society 2018.10.01 Seattle

Lei Mon S, Yoshioka K, Kunieda T, Asami Y, Piao W, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A novel structure of double stranded heteroduplex oligonucleotides for intracerebroventricular application. ⽇本核酸医薬学会 第 4 回年会 2018.07.10 福岡

Asami Y, Yoshioka K, Kunieda T, Guo H, Miyata H, Yoshida-Tanaka K, Kuwahara H, Nishina K, Nagata T, Yokota T. Intracellular mechanisms of hetero duplex oligonucleotide targeting micro RNA.. 日本核酸医薬学会第4回年会 2018.07.09 福岡

Lei Mon S, Yoshioka K, Kunieda T, Asami Y, Piao W, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A novel structure of duplex antisense oligonucleotides improves. 第59回⽇本神経学会学術⼤会 2018.05.23 札幌

Yoshioka　LK, Kunieda T, Asami Y, Sujino Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Dual overhanging duplex oligonucleotide improved efficacy and safety in gene therapy for FAP. XXⅢ World Congress of Neurology 2017 2017.09.20 京都

Kanazawa T, Nose Y, Asami Y, Nonami J, Iijima M, Tanaka H, Yokota T. Clinical features of patients with motor fluctuations before intravenous thrombolysia. 第57回日本神経学会学術大会 2016.05.20 神戸