Personnel Information

写真a

ASAMI Yutaro


Job title

Visiting Lecturer

Birth date

1986

Mail Address

y-asami.nuro@tmd.ac.jp

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Graduating School 【 display / non-display 】

  • University of Miyazaki, Faculty of Medicine, 2012.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2021.03, Completed

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Degree 【 display / non-display 】

  • Doctor of philosophy in medical science, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2012.04
    -
    2013.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Trainee Resident
  • 2014.04
    -
    2015.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Senior Resident
  • 2016.04
    -
    2021.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Graduate Student
  • 2021.06
    -
    2021.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2021.10
    -
    2022.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Assistant Professor
  • 2022.07
    -
    2023.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2023.10
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Cognitive and Behavioral Medicine， Department of Neurology and Neurological Science， Visiting Lecturer

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External Career 【 display / non-display 】

  • 2013.04
    -
    2014.03
    , Trainee Resident
  • 2015.04
    -
    2016.03
    , Senior Resident
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Academic Society Affiliations 【 display / non-display 】

  • Japanese society of neurology

  • The Japanese society of internal medicine

  • The Jaapanese neuro-ophthalmology society

  • Nucleic Acids Therapeutics Society of Japan

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Research Areas 【 display / non-display 】

  • Neurology

  • Pharmaceutical chemistry and drug development sciences

  • Molecular biology

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Qualification Acquired 【 display / non-display 】

  • Doctor

  • German Skill Authorization (1or semi-2 class)

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Published Papers & Misc 【 display / non-display 】

  1. Yagi Yohsuke, Asami Yutaro, Kyoya Mitsuki, Yokota Takanori. Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination NEUROLOGICAL SCIENCES. 2021.11; 43 (1): 41-43. ( PubMed, DOI )

  2. Asami Yutaro, Nagata Tetsuya, Yoshioka Kotaro, Kunieda Taiki, Yoshida-Tanaka Kie, Bennett C. Frank, Seth Punit P., Yokota Takanori. Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo MOLECULAR THERAPY. 2021.02; 29 (2): 838-847. ( PubMed, DOI )

  3. Asami Yutaro, Nagata Tetsuya, Yoshioka Kotaro, Kunieda Taiki, Yoshida-Tanaka Kie, Yokota Takanori. in vivoにおけるDNA/DNA二重鎖オリゴヌクレオチドによる効率的な遺伝子抑制(Efficient gene suppression by DNA/DNA double-stranded oligonucleotide in vivo) 臨床神経学. 2020.11; 60 (Suppl.): S498. ( ichushi )

  4. Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハングしたヘテロ二重鎖オリゴヌクレオチドを用いたFAPのトランスフェリンを介した送達による治療(Treatment for FAP with overhanging heteroduplex oligonucleotides by transferrin-mediated delivery) 臨床神経学. 2020.11; 60 (Suppl.): S315. ( ichushi )

  5. Lei Mon Su Su, Yoshioka Kotaro, Jia Chunyan, Kunieda Taiki, Asami Yutaro, Yoshida-Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route FEBS LETTERS. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )

  6. Yoshioka Kotaro, Su Su Lei Mon , Jia Chunyan, Yamada Hiroki, Asami Yutaro, Tanaka Kie, Wenying Piao, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. CNSを標的としたオーバーハングヘテロ二2本鎖核酸を用いた新しいアンチセンスオリゴヌクレオチド治療(A novel antisense oligonucleotide therapy by overhanging heteroduplex oligonucleotide targeting CNS) 臨床神経学. 2019.11; 59 (Suppl.): S408. ( ichushi )

  7. Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huijia, Miyata Haruka, Yoshida-Tanaka Kie, Sujino Yumiko, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Hara Rintaro Iwata, Nagata Tetsuya, Wada Takeshi, Obika Satoshi, Yokota Takanori. Highly efficient silencing of microRNA by heteroduplex oligonucleotides NUCLEIC ACIDS RESEARCH. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  8. Mon Su Su Lei, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. アンチセンスオリゴヌクレオチド二本鎖の新しい構造は脳室内経路を介した効果を改善する(A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route) 臨床神経学. 2018.12; 58 (Suppl.): S394. ( ichushi )

  9. Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huija, Enomoto Seiya, Miyata Haruka, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新しい種類の二本鎖オリゴヌクレオチドはin vivoにおいてmicroRNAサイレンシングの効力を増強する(A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing) 臨床神経学. 2018.12; 58 (Suppl.): S234. ( ichushi )

  10. Guo Huijia, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Miyata Haruka, Yoshida-Tanaka Kie, Nagata Tetsuya, Yokota Takanori. 脂質結合二重鎖アンチセンスオリゴヌクレオチドによるマイクロRNAのサイレンシングの効力(Efficacy of microRNA silencing by lipid-conjugated double-stranded antisense oligonucleotides) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 83-88. ( ichushi )

  11. Yoshioka K., Kunieda T., Asami Y., Sujino Y., Tanaka K., Piao W., Kuwahara H., Nishina K., Nagata T., Yokota T.. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 140. ( DOI )

  12. Asami Y, Yoshioka K, Nishina K, Nagata T, Yokota T. Drug delivery system of therapeutic oligonucleotides Drug Discoveries & Therapeutics. 2016.10; 10 (5): 256-262. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Su Su Lei Mon , Yoshioka Kotaro, Jia Chunyan, Kunieda Taiki, Asami Yutaro, Yoshida-Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハング2本鎖核酸の脳室内投与による効果増強と毒性の緩和(Overhanging duplex oligonucleotide enhances potency and mitigates toxicity intracerebroventricularly). 臨床神経学 2021.09.01

  2. Yutaro Asami, Tetuya Nagata, Kotaro Yoshioka, Taiki Kunieda, Kie Yoshida-Tanaka, Takanori Yokota. Efficient gene suppression by DNA/DNA double-stranded oligonucleotide in vivo.. the 6th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan 2021.06.27 Web

  3. Asami Y,Nagata T,Yoshioka K,Kunieda T,Yoshida-Tanaka K,Yokota T. DNA/DNA Double-Stranded Oligonucleotide Suppresses Target RNA Efficiently In Vivo without Evident Innate Immune Responses.. 16th Annual Meeting of the Oligonucleotide Therapeutics Society 2020.09.27 Web

  4. Asami Y, Nagata T, Yoshioka K, Kunieda T, Tanaka-Yoshida K, Yokota T. Efficient gene suppression by DNA/DNA double-stranded oligonucleotide in vivo.. 第61回日本神経学会学術大会 2020.08.31 web

  5. Asami Y, Yoshioka K, Nagata T, Yokota T. Efficient target gene suppression effect of double stranded DNA structure type of oligonucleotide.. 15th Annual Meeting of the Oligonucleotide Therapeutics Society 2019.10.13 München

  6. Yoshioka K,Lei Mon S,Jia C,Yamada H,Asami Y,Tanaka K,Wenying P,Kuwahara H,Nishina K,Nagata T,Yokota T. A novel antisense oligonucleotide terapy by overhanging heteroduplex oligonucleotide targeting CNS. 第60回⽇本神経学会術大会 2019.05.23 大阪

  7. Asami Y, Yoshioka K, Kunieda T, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Iwata Hara R, Nagata T, Obika S, Wada T, Yokota T. Efficient microRNA silencing in vivo by heteroduplex oligonucleotides.. 遺伝子・デリバリー研究会第19回シンポジウム 2019.05.08 千葉

  8. Yoshioka K, Kunieda K, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Ito S, Nagata T, Yokota T. Overhanging heteroduplex oligonucleotides enable enhanced gene silencing by efficient delivery associated with transferrin. 14th Annual Meeting of the Oligonucleotide Therapeutics Society 2018.10.01 Seattle

  9. Lei Mon S, Yoshioka K, Kunieda T, Asami Y, Piao W, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A novel structure of double stranded heteroduplex oligonucleotides for intracerebroventricular application. ⽇本核酸医薬学会 第 4 回年会 2018.07.10 福岡

  10. Asami Y, Yoshioka K, Kunieda T, Guo H, Miyata H, Yoshida-Tanaka K, Kuwahara H, Nishina K, Nagata T, Yokota T. Intracellular mechanisms of hetero duplex oligonucleotide targeting micro RNA.. 日本核酸医薬学会第4回年会 2018.07.09 福岡

  11. Lei Mon S, Yoshioka K, Kunieda T, Asami Y, Piao W, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A novel structure of duplex antisense oligonucleotides improves. 第59回⽇本神経学会学術⼤会 2018.05.23 札幌

  12. Yoshioka　LK, Kunieda T, Asami Y, Sujino Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Dual overhanging duplex oligonucleotide improved efficacy and safety in gene therapy for FAP. XXⅢ World Congress of Neurology 2017 2017.09.20 京都

  13. Kanazawa T, Nose Y, Asami Y, Nonami J, Iijima M, Tanaka H, Yokota T. Clinical features of patients with motor fluctuations before intravenous thrombolysia. 第57回日本神経学会学術大会 2016.05.20 神戸

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Awards & Honors 【 display / non-display 】

  • Research Encouragement Program for Fostering Researchers (Drug Discovery-Related Fields) 2022，Japan Agency for Medical Research and Development，2022.11

  • 35th Research Encouragement Award，Tokyo Medical and Dental University Medical Alumni Association，2022.03

  • November 2020 Paper of the Month，Oligonucleotide Therapeutics Society，2020.11

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Others 【 display / non-display 】

  • Making therapeutic sense of antisense oligonucleotides，2021.01

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