Personnel Information

写真a

HOSOYA Tadashi


Job title

Junior Associate Professor

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

cell cycle regulation, rheumatoid arthritis
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, Graduated

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Campus Career 【 display / non-display 】

  • 2006.04
    -
    2007.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Trainee Resident
  • 2008.04
    -
    2009.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Resident
  • 2014.04
    -
    2016.02
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Assistant Professor
  • 2018.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Junior Associate Professor

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External Career 【 display / non-display 】

  • 2007.04
    -
    2008.03
    , Trainee Resident
  • 2009.04
    -
    2010.03
    , Senior Resident
  • 2015.04
    -
    2021.03
    , Assistant Professor
  • 2016.04
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    2018.03
    University of California, San Diego, Moores Cancer Center, Visiting scholar
  • 2016.04
    -
    2018.04
    University of California, San Diego, Moores Cancer Center, Visiting scholar
  • 2021.04
    -
    Now
    , Junior Associate Professor

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Academic Society Affiliations 【 display / non-display 】

  • The Japan Society of Human Genetics

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Academic Activity 【 display / non-display 】

  • 2020.04
    -
    2020.10
    Frontiers in Pharmacology Guest Editor
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Research Areas 【 display / non-display 】

  • Connective tissue disease and allergy

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Research Theme 【 display / non-display 】

  • The possible contribution of the Hippo pathway for the pathogenic phenotypes in rheumatoid arthritis synovial fibroblasts, 2022.04 - 2023.03

  • COVID-19感染症に伴う血管内皮障害の発生メカニズムの解明とその制御, 2020.12 - 2023.03

  • COVID-19感染症に伴う血管内皮障害の発生メカニズムの解明とその制御, 2020.12 - 2023.03

  • Pathological contribution of RA risk loci to the disease progression and the therapeutic response, 2015.04 - 2017.03

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Published Papers & Misc 【 display / non-display 】

  1. Mitsui Y, Suzuki T, Kuniyoshi K, Inamo J, Yamaguchi K, Komuro M, Watanabe J, Edamoto M, Li S, Kouno T, Oba S, Hosoya T, Masuhiro K, Naito Y, Koyama S, Sakaguchi N, Standley DM, Shin JW, Akira S, Yasuda S, Miyazaki Y, Kochi Y, Kumanogoh A, Okamoto T, Satoh T. Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity. Immunity. 2023.08; 56 (8): 1939-1954.e12. ( PubMed, DOI )

  2. Hanzawa S, Noda S, Hosoya T, Kawahara T, Nukui Y. Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis. Internal medicine (Tokyo, Japan). 2023.08; 62 (16): 2427-2431. ( PubMed, DOI )

  3. Hanzawa Satoshi, Noda Seiji, Hosoya Tadashi, Kawahara Tatsuo, Nukui Yoshihisa. 多発血管炎性肉芽腫症において大血管の圧迫をきたした腫瘤様病変(Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis) Internal Medicine. 2023.08; 62 (16): 2427-2431. ( ichushi )

  4. Baba, H; Sugihara, T; Ishizaki, T; Nomura, M; Hosoya, T; Kamiya, M; Matsumoto, T; Kubo, K; Hirano, F; Miyasaka, N; Kojima, M; Yasuda, S; Harigai, M. LONG-TERM OUTCOMES OF METHOTREXATE IN ELDERLY-ONSET RA IMPLEMENTING THE TREAT-TOTARGET STRATEGY ANNALS OF THE RHEUMATIC DISEASES. 2023.06; 82 1293-1294. ( DOI )

  5. Hosoya T, Oba S, Komiya Y, Kawata D, Kamiya M, Iwai H, Miyamoto S, Kataoka M, Tobiume M, Kanno T, Ainai A, Sato H, Hirakawa A, Mitsui Y, Satoh T, Wakabayashi K, Yamada T, Otomo Y, Miyazaki Y, Hasegawa H, Suzuki T, Yasuda S. Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 2023.05; 120 (22): e2300155120. ( PubMed, DOI )

  6. Fujiwara Shun, Kawamoto Ami, Motobayashi Maiko, Hibiya Shuji, Takenaka Kento, Shimizu Hiromichi, Saito Eiko, Fujii Toshimitsu, Nagahori Masakazu, Kawata Daisuke, Umezawa Natsuka, Hosoya Tadashi, Yasuda Shinsuke, Ohtsuka Kazuo, Okamoto Ryuichi. インフリキシマブが奏効したベーチェット病患者に認められた出血性胃潰瘍(Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab) DEN Open. 2023.04; 3 (1): 1 of 5-5 of 5. ( ichushi )

  7. Itakura T, Sasaki H, Hosoya T, Yamaguchi T, Mimori E, Saimon Y, Iwai H, Umezawa N, Kawata D, Kimura N, Kurata M, Shimizu M, Yasuda S. A novel gain-of-function missense variant in PLCG2 associated with autoinflammation and hypergammaglobulinemia. Rheumatology (Oxford, England). 2023.04; 62 (11): e319-e321. ( PubMed, DOI )

  8. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed, DOI )

  9. Umezawa N, Mizoguchi F, Maejima Y, Kimura N, Hasegawa H, Hosoya T, Fujimoto M, Kohsaka H, Naka T, Yasuda S. Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides. Frontiers in medicine. 2023; 10 1153883. ( PubMed, DOI )

  10. Oba S, Hosoya T, Kaneshige R, Kawata D, Yamaguchi T, Mitsumura T, Shimada S, Shibata S, Tateishi T, Koike R, Tohda S, Hirakawa A, Yoko N, Otomo Y, Nojima J, Miyazaki Y, Yasuda S. Thrombosis and antiphospholipid antibodies in Japanese COVID-19: based on propensity score matching. Frontiers in immunology. 2023; 14 1227547. ( PubMed, DOI )

  11. Komiya Y, Sugihara T, Hirano F, Matsumoto T, Kamiya M, Sasaki H, Hosoya T, Kimura N, Ishizaki T, Mori M, Tohma S, Yasuda S, Matsui T. Factors associated with impaired physical function in elderly rheumatoid arthritis patients who had achieved low disease activity. Modern rheumatology. 2022.12; 34 (1): 60-67. ( PubMed, DOI )

  12. Noda S, Hosoya T, Komiya Y, Tagawa Y, Endo K, Komori K, Koga H, Takahara Y, Sugimoto K, Sekiya I, Saito T, Mizoguchi F, Yasuda S. Correction: CD34(+)THY1(+) synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro. Arthritis research & therapy. 2022.09; 24 (1): 224. ( PubMed, DOI )

  13. Tadashi Hosoya, Tetsuya Saito, Hiroyuki Baba, Nao Tanaka, Seiji Noda, Youji Komiya, Yasuhiro Tagawa, Akio Yamamoto, Fumitaka Mizoguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka, Shinsuke Yasuda. Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts. Rheumatology (Oxford). 2022.08; 61 (8): 3427-3438. ( PubMed, DOI )

  14. Tomoko Niwano, Tadashi Hosoya, Saori Kadowaki, Etsushi Toyofuku, Takuya Naruto, Masaki Shimizu, Hidenori Ohnishi, Ryuji Koike, Tomohiro Morio, Kohsuke Imai, Masayuki Yoshida, Shinsuke Yasuda. An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa. Rheumatology (Oxford). 2022.05; 61 (11): e337-e340. ( PubMed, DOI )

  15. Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori, Shinsuke Yasuda. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. Arthritis Res Ther. 2022.04; 24 (1): 92. ( PubMed, DOI )

  16. Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi, Shinsuke Yasuda. synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro. Arthritis Res Ther. 2022.02; 24 (1): 45. ( PubMed, DOI )

  17. Tetsuya Saito, Nikunj M Shukla, Fumi Sato-Kaneko, Yukiya Sako, Tadashi Hosoya, Shiyin Yao, Fitzgerald S Lao, Karen Messer, Minya Pu, Michael Chan, Paul J Chu, Howard B Cottam, Tomoko Hayashi, Dennis A Carson, Maripat Corr. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022.01; 17 (1): 217-229. ( PubMed, DOI )

  18. Yamamoto A, Saito T, Hosoya T, Kawahata K, Asano Y, Sato S, Mizoguchi F, Yasuda S, Kohsaka H. Therapeutic effect of cyclin-dependent kinase 4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis. Arthritis & rheumatology (Hoboken, N.J.). 2021.12; 74 (5): 860-870. ( PubMed, DOI )

  19. Seiya Oba, Tadashi Hosoya, Miki Amamiya, Takahiro Mitsumura, Daisuke Kawata, Hirokazu Sasaki, Mari Kamiya, Akio Yamamoto, Takahiro Ando, Sho Shimada, Tsuyoshi Shirai, Tsukasa Okamoto, Tomoya Tateishi, Akira Endo, Junichi Aiboshi, Nobuyuki Nosaka, Hideo Yamanouchi, Toyomu Ugawa, Eiki Nagaoka, Keiji Oi, Susumu Tao, Yasuhiro Maejima, Yukie Tanaka, Kousuke Tanimoto, Hiroaki Takeuchi, Shuji Tohda, Akihiro Hirakawa, Tetsuo Sasano, Hirokuni Arai, Yasuhiro Otomo, Yasunari Miyazaki, Shinsuke Yasuda. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Front Cardiovasc Med. 2021.11; 8 767074. ( PubMed, DOI )

  20. Hosoya T, Oda G, Nakagawa T, Onishi I, Hosoya T, Ishiguro M, Ishikawa T, Uetake H. Plasma Levels of Decorin Increased in Patients during the Progression of Breast Cancer. Journal of clinical medicine. 2021.11; 10 (23): 5530. ( PubMed, DOI )

  21. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Frontiers in immunology. 2021.09; 12 701445. ( PubMed, DOI )

  22. Tadashi Hosoya, Dunai Cordelia, Benedict D Michael, Chie Miyabe, Jun Nagai, Thomas T Murooka, Yoshishige Miyabe. Editorial: Targeting the Chemoattractant System in Inflammation. Front Pharmacol. 2021.08; 12 744290. ( PubMed, DOI )

  23. Tadashi Hosoya, Takahiko Sugihara, Nobuyuki Miyasaka, Shinsuke Yasuda. Novel treatment strategy of polymyalgia rheumatica targeting drug-free remission. Clin Exp Rheumatol. 2021.05; 39 (3): 701-702. ( PubMed, DOI )

  24. Sugihara T, Ishizaki T, Onoguchi W, Baba H, Matsumoto T, Iga S, Kubo K, Kamiya M, Hirano F, Hosoya T, Miyasaka N, Harigai M. Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study. Rheumatology (Oxford, England). 2021.01; 60 (9): 4252-4261. ( PubMed, DOI )

  25. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Frontiers in pharmacology. 2020.11; 11 607713. ( PubMed, DOI )

  26. Fumi Sato-Kaneko, Xiaodong Wang, Shiyin Yao, Tadashi Hosoya, Fitzgerald S. Lao, Karen Messer, Minya Pu, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Dennis A. Carson, Maripat Corr, and Tomoko Hayashi. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy BioMed Research International. 2018.09; ( DOI )

  27. Sugihara Takahiko, Ishizaki Tatsuro, Baba Hiroyuki, Matsumoto Takumi, Iga Shoko, Kusuda Takeshi, Tsuchida Marina, Kamiya Mari, Komiya Yoji, Hirano Fumio, Hosoya Tadashi, Miyasaka Nobuyuki, Harigai Masayoshi. Three Year Outcomes of Patients with Elderly-Onset Rheumatoid Arthritis Treated with a Therapeutic Strategy Targeting Low Disease Activity, and Impact of Adverse Events on Physical Function ARTHRITIS & RHEUMATOLOGY. 2018.09; 70

  28. Tadashi Hosoya, Fumi Sato-Kaneko, Alast Ahmadi, Shiyin Yao, Fitzgerald Lao, Kazutaka Kitaura, Takaji Matsutani, Dennis A Carson, Tomoko Hayashi. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc. Natl. Acad. Sci. U.S.A.. 2018.07; 115 (29): E6836-E6844. ( PubMed, DOI )

  29. Kenji Oku, Tatsuya Atsumi, Yuji Akiyama, Hirofumi Amano, Naoto Azuma, Toshiyuki Bohgaki, Yu Funakubo Asanuma, Tetsuya Horita, Tadashi Hosoya, Kunihiro Ichinose, Masaru Kato, Yasuhiro Katsumata, Yasushi Kawaguchi, Atsushi Kawakami, Tomohiro Koga, Hitoshi Kohsaka, Yuya Kondo, Kanae Kubo, Masataka Kuwana, Akio Mimori, Tsuneyo Mimori, Toshihide Mimura, Kosaku Murakami, Kazuhisa Nakano, Shingo Nakayamada, Hiroshi Ogishima, Kazumasa Ohmura, Kazuyoshi Saito, Hajime Sano, Mihoko Shibuya, Yuko Takahashi, Yoshinari Takasaki, Tsutomu Takeuchi, Naoto Tamura, Yoshiya Tanaka, Hiroto Tsuboi, Shinichiro Tsunoda, Naoichiro Yukawa, Noriyuki Yamakawa, Kazuhiko Yamamoto, Takayuki Sumida. Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC). Mod Rheumatol. 2018.07; 28 (4): 642-648. ( PubMed, DOI )

  30. Oku Kenji, Atsumi Tatsuya, Akiyama Yuji, Amano Hirofumi, Azuma Naoto, Bohgaki Toshiyuki, Funakubo Asanuma Yu, Horita Tetsuya, Hosoya Tadashi, Ichinose Kunihiro, Kato Masaru, Katsumata Yasuhiro, Kawaguchi Yasushi, Kawakami Atsushi, Koga Tomohiro, Kohsaka Hitoshi, Kondo Yuya, Kubo Kanae, Kuwana Masataka, Mimori Akio, Mimori Tsuneyo, Mimura Toshihide, Murakami Kosaku, Nakano Kazuhisa, Nakayamada Shingo, Ogishima Hiroshi, Ohmura Kazumasa, Saito Kazuyoshi, Sano Hajime, Shibuya Mihoko, Takahashi Yuko, Takasaki Yoshinari, Takeuchi Tsutomu, Tamura Naoto, Tanaka Yoshiya, Tsuboi Hiroto, Tsunoda Shinichiro, Yukawa Naoichiro, Yamakawa Noriyuki, Yamamoto Kazuhiko, Sumida Takayuki. Systemic Lupus International Collaborating Clinics(SLICC)によって確立された全身性エリテマトーデスの代替分類基準の評価(Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics(SLICC)) Modern Rheumatology. 2018.07; 28 (4): 642-648. ( ichushi )

  31. Nikunj M Shukla, Kei-Ichiro Arimoto, Shiyin Yao, Jun-Bao Fan, Yue Zhang, Fumi Sato-Kaneko, Fitzgerald S Lao, Tadashi Hosoya, Karen Messer, Minya Pu, Howard B Cottam, Dennis A Carson, Tomoko Hayashi, Dong-Er Zhang, Maripat Corr. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018.05; 23 (9): 2472555218774308. ( PubMed, DOI )

  32. Fumi Sato-Kaneko, Xiaodong Wang, Shiyin Yao, Tadashi Hosoya, Fitzgerald S Lao, Karen Messer, Minya Pu, Nikunj M Shukla, Howard B Cottam, Michael Chan, Dennis A Carson, Maripat Corr, Tomoko Hayashi. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. BioMed research international. 2018; 2018 8091283. ( PubMed, DOI )

  33. Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S Zhang, Tadashi Hosoya, Megan M Kaneda, Judith A Varner, Minya Pu, Karen S Messer, Cristiana Guiducci, Robert L Coffman, Kazutaka Kitaura, Takaji Matsutani, Ryuji Suzuki, Dennis A Carson, Tomoko Hayashi, Ezra Ew Cohen. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017.09; 2 (18): ( PubMed, DOI )

  34. H Takada, T Hosoya, N Kimura, K Kawahata, H Kohsaka. Successful use of rituximab in a patient with refractory thrombotic thrombocytopaenic purpura complicated by polymyositis. Scand. J. Rheumatol.. 2017.03; 46 (2): 163-165. ( PubMed, DOI )

  35. Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression. Ann. Rheum. Dis.. 2016.01; 75 (1): 253-259. ( PubMed, DOI )

  36. Takeshi Kusuda, Tadashi Hosoya, Takayasu Mori, Katsuhito Ihara, Hidenori Nishida, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Ryuji Koike, Shinichi Uchida, Hitoshi Kohsaka. Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation. Intern. Med.. 2016.01; 55 (21): 3201-3204. ( PubMed, DOI )

  37. Takahiko Sugihara, Tatsuro Ishizaki, Tadashi Hosoya, Shoko Iga, Waka Yokoyama, Fumio Hirano, Nobuyuki Miyasaka, Masayoshi Harigai. Structural and functional outcomes of a therapeutic strategy targeting low disease activity in patients with elderly-onset rheumatoid arthritis: a prospective cohort study (CRANE). Rheumatology (Oxford). 2015.05; 54 (5): 798-807. ( PubMed, DOI )

  38. Tadashi Hosoya, Fumitaka Mizoguchi, Hisanori Hasegawa, Keiko Miura, Ryuji Koike, Tetsuo Kubota, Nobuyuki Miyasaka, Hitoshi Kohsaka. A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor (TNF) Receptor-associated Periodic Syndrome (TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab. Intern. Med.. 2015; 54 (16): 2069-2072. ( PubMed, DOI )

  39. Mari Kihara, Takahiko Sugihara, Tadashi Hosoya, Nobuyuki Miyasaka. Clinical significance of complement as a biomarker of disease activity in 4 cases of IgG4-related disease with retroperitoneal fibrosis. Clin. Exp. Rheumatol.. 2013.11; 31 (6): 947-949. ( PubMed )

  40. Toshihiro Nanki, Ikumi Onoue, Kenji Nagasaka, Aiko Takayasu, Masashi Ebisawa, Tadashi Hosoya, Toshizumi Shirai, Takahiko Sugihara, Shinya Hirata, Tetsuo Kubota, Masayoshi Harigai, Nobuyuki Miyasaka. Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections. Ann. Rheum. Dis.. 2013.06; 72 (6): 1100-1102. ( PubMed, DOI )

  41. Sugihara Takahiko, Ishizaki Tatsuro, Hosoya Tadashi, Iga Shoko, Yokoyama Waka, Hirano Fumio, Miyasaka Nobuyuki, Harigai Masayoshi. Treat-to-Target Strategy Aiming At Achievement of Structural and Functional Remission in Patients with Active Elderly-Onset Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM. 2012.10; 64 (10): S161-S162.

  42. Kayoko Kaneko, Toshihiro Nanki, Tadashi Hosoya, Fumitaka Mizoguchi, Nobuyuki Miyasaka. Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis. Mod Rheumatol. 2010.12; 20 (6): 632-636. ( PubMed, DOI )

  43. Kaneko Kayoko, Nanki Toshihiro, Hosoya Tadashi, Mizoguchi Fumitaka, Miyasaka Nobuyuki. 関節リウマチ患者2例におけるエタネルセプトで誘発された壊死性半月体形成性糸球体腎炎(Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis) Modern Rheumatology. 2010.12; 20 (6): 632-636. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

  1. Baba Hiroyuki, Hosoya Tadashi, Kondo Yuma, Ishida Ryosuke, Hatsuzawa Saki, Kagechika Hiroyuki, Yasuda Shinsuke. Cytokines and Chemokines-1(Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models). 日本免疫学会総会・学術集会記録 2022.11.01

  2. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. Infection and Immunity II(The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  3. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. 感染と免疫II　COVID-19の肥満患者における悪化の根本的なメカニズム(Infection and Immunity II　The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  4. Baba Hiroyuki, Hosoya Tadashi, Kondo Yuma, Ishida Ryosuke, Hatsuzawa Saki, Kagechika Hiroyuki, Yasuda Shinsuke. サイトカインとケモカイン-1　二つの炎症性動物モデルにおける新規NF-κB阻害化合物の抗炎症作用(Cytokines and Chemokines-1　Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models). 日本免疫学会総会・学術集会記録 2022.11.01

  5. Seiya Oba, Tadashi Hosoya, Shinsuke Yasuda. Arterial and venous thrombosis complicated in COVID-19; a retrospective single center analysis in Japan. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.09

  6. Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda. Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts.. ACR Convergence 2021 2021.11.06

  7. Oba Seiya, Hosoya Tadashi, Yasuda Shinsuke. Arterial and venous thrombosis complicated in COVID-19: a retrospective single center analysis in Japan(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  8. Hosoya Tadashi, Tagawa Yasuhiro, Baba Hiroyuki, Noda Seiji, Yasuda Shinsuke. The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  9. Noda Seiji, Hosoya Tadashi, Tagawa Yasuhiro, Yasuda Shinsuke. Remarkable osteogenic and chondrogenic potentials in CD34+ THY1+ synovial fibroblast subest(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  10. Noda Seiji, Hosoya Tadashi, Tagawa Yasuhiro, Yasuda Shinsuke. CD34+THY1+滑膜線維芽細胞サブセットにおける著明な骨形成能と軟骨形成能(Remarkable osteogenic and chondrogenic potentials in CD34+ THY1+ synovial fibroblast subest). 日本免疫学会総会・学術集会記録 2021.11.01

  11. Hosoya Tadashi, Tagawa Yasuhiro, Baba Hiroyuki, Noda Seiji, Yasuda Shinsuke. 関節リウマチ滑膜線維芽細胞においてサイクリン依存性キナーゼ4および6の活性化はJUNを安定化させることによりMMP-1/3産生に寄与している(The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts). 日本免疫学会総会・学術集会記録 2021.11.01

  12. Oba Seiya, Hosoya Tadashi, Yasuda Shinsuke. COVID-19に合併した動脈および静脈血栓症　日本における後向き単施設解析(Arterial and venous thrombosis complicated in COVID-19: a retrospective single center analysis in Japan). 日本免疫学会総会・学術集会記録 2021.11.01

  13. Noda Seiji, Hosoya Tadashi, Tagawa Yasuhiro, Yasuda Shinsuke. CD34+THY1+滑膜線維芽細胞サブセットにおける著明な骨形成能と軟骨形成能(Remarkable osteogenic and chondrogenic potentials in CD34+ THY1+ synovial fibroblast subest). 日本免疫学会総会・学術集会記録 2021.11.01

  14. Oba Seiya, Hosoya Tadashi, Yasuda Shinsuke. COVID-19に合併した動脈および静脈血栓症　日本における後向き単施設解析(Arterial and venous thrombosis complicated in COVID-19: a retrospective single center analysis in Japan). 日本免疫学会総会・学術集会記録 2021.11.01

  15. Hosoya Tadashi, Tagawa Yasuhiro, Baba Hiroyuki, Noda Seiji, Yasuda Shinsuke. 関節リウマチ滑膜線維芽細胞においてサイクリン依存性キナーゼ4および6の活性化はJUNを安定化させることによりMMP-1/3産生に寄与している(The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts). 日本免疫学会総会・学術集会記録 2021.11.01

  16. Noda Seiji, Hosoya Tadashi, Tagawa Yasuhiro, Yasuda Shinsuke. CD34+THY1+滑膜線維芽細胞サブセットにおける著明な骨形成能と軟骨形成能(Remarkable osteogenic and chondrogenic potentials in CD34+ THY1+ synovial fibroblast subest). 日本免疫学会総会・学術集会記録 2021.11.01

  17. Oba Seiya, Hosoya Tadashi, Yasuda Shinsuke. COVID-19に合併した動脈および静脈血栓症　日本における後向き単施設解析(Arterial and venous thrombosis complicated in COVID-19: a retrospective single center analysis in Japan). 日本免疫学会総会・学術集会記録 2021.11.01

  18. Hosoya Tadashi, Tagawa Yasuhiro, Baba Hiroyuki, Noda Seiji, Yasuda Shinsuke. 関節リウマチ滑膜線維芽細胞においてサイクリン依存性キナーゼ4および6の活性化はJUNを安定化させることによりMMP-1/3産生に寄与している(The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts). 日本免疫学会総会・学術集会記録 2021.11.01

  19. Tadashi Hosoya, Hiroyuki Baba, Shinsuke Yasuda, Maripat Corr. Novel compound that impacts migration and chemokine production via NFkB suppressing activity. 日本リウマチ学会総会 International Concurrent Workshop 2021.04.28

  20. Identification of Small Molecules with Efficacy as Steroid Sparing Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-like Synoviocytes. 2020.10.01

  21. Three Year Outcomes of Patients with Elderly-Onset Rheumatoid Arthritis Treated with a Therapeutic Strategy Targeting Low Disease Activity, and Impact of Adverse Events on Physical Function. 2018.09.01

  22. Oku Kenji, Atsumi Tatsuya, Akiyama Yuji, Amano Hirofumi, Azuma Naoto, Bohgaki Toshiyuki, Funakubo Asanuma Yu, Horita Tetsuya, Hosoya Tadashi, Ichinose Kunihiro, Kato Masaru, Katsumata Yasuhiro, Kawaguchi Yasushi, Kawakami Atsushi, Koga Tomohiro, Kohsaka Hitoshi, Kondo Yuya, Kubo Kanae, Kuwana Masataka, Mimori Akio, Mimori Tsuneyo, Mimura Toshihide, Murakami Kosaku, Nakano Kazuhisa, Nakayamada Shingo, Ogishima Hiroshi, Ohmura Kazumasa, Saito Kazuyoshi, Sano Hajime, Shibuya Mihoko, Takahashi Yuko, Takasaki Yoshinari, Takeuchi Tsutomu, Tamura Naoto, Tanaka Yoshiya, Tsuboi Hiroto, Tsunoda Shinichiro, Yukawa Naoichiro, Yamakawa Noriyuki, Yamamoto Kazuhiko, Sumida Takayuki. Systemic Lupus International Collaborating Clinics(SLICC)によって確立された全身性エリテマトーデスの代替分類基準の評価(Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics(SLICC)). Modern Rheumatology 2018.07.01

  23. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. Systemic immune diseases Paradoxical Modulation Strategies for Systemic Autoimmune Diseases(和訳中). 日本免疫学会総会・学術集会記録 2017.12.01

  24. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. 全身性免疫疾患　全身性自己免疫疾患に対する奇異な制御法(Systemic immune diseases　Paradoxical Modulation Strategies for Systemic Autoimmune Diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  25. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. 全身性免疫疾患　全身性自己免疫疾患に対する奇異な制御法(Systemic immune diseases　Paradoxical Modulation Strategies for Systemic Autoimmune Diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  26. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. 全身性免疫疾患　全身性自己免疫疾患に対する奇異な制御法(Systemic immune diseases　Paradoxical Modulation Strategies for Systemic Autoimmune Diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  27. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. 全身性免疫疾患　全身性自己免疫疾患に対する奇異な制御法(Systemic immune diseases　Paradoxical Modulation Strategies for Systemic Autoimmune Diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  28. Tadashi Hosoya, Fumi Sato-Kaneko, Alast Ahmadi, Shiyin Yao, Fitzgerald S Lao, Takaji Matsutani, Dennis A Carson, Tomoko Hayashi. Immunotherapy with a phospholipid-conjugated TLR7 ligand prevents lung metastasis. La Jolla immunology conference 2017.10.18

  29. Kusuda Takeshi, Hosoya Tadashi, Mori Takayasu, Ihara Katsuhito, Nishida Hidenori, Chiga Motoko, Sohara Eisei, Rai Tatemitsu, Koike Ryuji, Uchida Shinichi, Kohsaka Hitoshi. SLC12A3ヘテロ接合変異を有する抗SSA抗体陽性患者における後天性Gitelman症候群(Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation). Internal Medicine 2016.11.01

  30. Hosoya Tadashi, Mizoguchi Fumitaka, Hasegawa Hisanori, Miura Keiko, Koike Ryuji, Kubota Tetsuo, Miyasaka Nobuyuki, Kohsaka Hitoshi. TNFRSF1A遺伝子変異を認めず、トシリズマブ投与が奏効した、腫瘍壊死因子(TNF)受容体関連周期性症候群(TRAPS)の臨床的特徴を示す1症例. Internal Medicine 2015.08.01

  31. Tadashi Hosoya, Kimito Kawahata,Hideyuki Iwai, Hitoshi Kohsaka. Cell cycle regulation therapy, when combined with TNF blockade, exerted significant therapeutic effects even in the late stage of a rheumatoid arthritis model. ACR/ARHP Annual Meeting 2014.11.18 Boston

  32. The Combination Therapy of Cell Cycle Regulation Therapy Combined and TNF Blockade Ameliorated the Established Arthritis.. 2014.10.01

  33. Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression.. 58th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2014.04.24 Tokyo

  34. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬 サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  35. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因 サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  36. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  37. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬　サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  38. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  39. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬　サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  40. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  41. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  42. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬　サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  43. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  44. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬　サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  45. Hosoya Tadashi, Iwai Hideyuki, Miyasaka Nobuyuki, Kohsaka Hitoshi. サイトカイン遮断を併用した細胞周期調節療法は、免疫抑制増加を伴わずに抗関節炎効果を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本免疫学会総会・学術集会記録 2013.11.01

  46. Cell Cycle Regulation Therapy Combined With Cytokine Blockade Enhances Anti-Arthritic Effects Without Increase Of Immune Suppression. 2013.10.01

  47. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価 マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  48. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価　マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  49. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価　マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  50. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価　マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  51. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価　マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  52. Treat-to-Target Strategy Aiming At Achievement of Structural and Functional Remission in Patients with Active Elderly-Onset Rheumatoid Arthritis.. 2012.10.01

  53. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ 関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  54. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ　関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  55. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ　関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  56. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ　関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  57. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ　関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  58. Kaneko Kayoko, Nanki Toshihiro, Hosoya Tadashi, Mizoguchi Fumitaka, Miyasaka Nobuyuki. 関節リウマチ患者2例におけるエタネルセプトで誘発された壊死性半月体形成性糸球体腎炎(Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis). Modern Rheumatology 2010.12.01

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