Alkebaier Aobulikasimu, Tao Liu, Jinying Piao, Shingo Sato, Hiroki Ochi, Atsushi Okawa, Kunikazu Tsuji, Yoshinori Asou. SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption Sci Rep. 2023.05; 13 (1): 7991. ( PubMed, DOI )

Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi. l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis JCI Insight. 2023.04; 8 (7): e154925. ( PubMed, DOI )

Kurando Utagawa, Takaei Shin, Hironori Yamada, Hiroki Ochi, Satoko Sunamura, Aiko Unno, Chihiro Akazawa, Masatsugu Ema, Shu Takeda, Atsushi Okawa, Shingo Sato. Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation Sci Rep. 2023.03; 13 (1): 4674. ( PubMed, DOI )

Anniwaer Gilinazi, Tsuji Kunikazu, Sato Shingo, Miyata Toshio, Okawa Atsushi, Asou Yoshinori. PAI-1 inhibitor TM5614 leads osteosarcoma cells to G2 arrest Journal of Medical and Dental Sciences. 2023; 70 23-32. ( ichushi )

Anri Koyanagi, Iichiroh Onishi, Karin Muraoka, Ikue Sato, Shingo Sato, Tsuyoshi Kimura, Akio Kishida, Kouhei Yamamoto, Masanobu Kitagawa, Morito Kurata. Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone Bioengineering. 2022.09; 9 (10): 490. ( PubMed, DOI )

Ichiro Takada, Shinya Hidano, Sayuri Takahashi, Kaori Yanaka, Hidesato Ogawa, Megumi Tsuchiya, Atsushi Yokoyama, Shingo Sato, Hiroki Ochi, Tohru Nakagawa, Takashi Kobayashi, Shinichi Nakagawa, Makoto Makishima. Transcriptional coregulator Ess2 controls survival of post-thymic CD4 + T cells through the Myc and IL-7 signaling pathways J Biol Chem. 2022.09; 298 (9): 102342. ( PubMed, DOI )

Takanori Yamada, Kazuya Fukasawa, Tetsuhiro Horie, Takuya Kadota, Jiajun Lyu, Kazuya Tokumura, Shinsuke Ochiai, Sayuki Iwahashi, Akane Suzuki, Gyujin Park, Rie Ueda, Megumi Yamamoto, Tatsuya Kitao, Hiroaki Shirahase, Hiroki Ochi, Shingo Sato, Takashi Iezaki, Eiichi Hinoi. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis Stem Cell Reports. 2022.07; 17 (7): 1576-1588. ( PubMed, DOI )

Tsukamoto K, Koyanagi H, Nakagawa Y, Sato S, Koga H, Yoshii T, Okawa A. Parkes-Weber syndrome – knee arteriovenous malformation with extensive bone destruction: Safe and effective alternative limb-preservation surgeries Annals of Vascular Surgery - Brief Reports and Innovations. 2022.06; 2 (2): 100094.

Tomoyuki Tanaka, Akira Takahashi, Yutaka Kobayashi, Masanori Saito, Sun Xiaolong, Chen Jingquan, Yoshiaki Ito, Tsuyoshi Kato, Hiroki Ochi, Shingo Sato, Toshitaka Yoshii, Atsushi Okawa, Peter Carlsson, Hiroyuki Inose. Foxf2 represses bone formation via Wnt2b/β-catenin signaling Exp Mol Med. 2022.06; 54 (6): 753-764. ( PubMed, DOI )

Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi. Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood Stem Cells. 2022.04; 40 (4): 411-422. ( PubMed, DOI )

Reina Miyamoto, Takashi Hirai, Toshitaka Yoshii, Hiroaki Onuma, Hiroyuki Inose, Masato Yuasa, Yu Matsukura, Shingo Morishita, Kouhei Yamamoto, Hirotaka Koyanagi, Shingo Sato, Kazuyoshi Yagishita, Atsushi Okawa. Surgical Strategy for Osteoid Osteoma Localized in Anterior Lumbar Vertebral Body: A Case Report Spine Surg Relat Res. 2022; 6 (4): 408-411. ( PubMed, DOI )

Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N. Mechanical load regulates bone growth via periosteal Osteocrin Cell reports. 2021.07; 36 (2): 109380. ( PubMed, DOI )

Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Keisuke Akaike, Aiko Kurisaki-Arakawa, Shingo Sato, Eisuke Kobayashi, Sho Mizuno, Toshihide Ueno, Takeshi Morii, Tomotake Okuma, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Keita Sasa, Taketo Okubo, Youngji Kim, Hiroyuki Mano, Tsuyoshi Saito. Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma Clin Orthop Relat Res. 2021.04; 479 (4): 838-852. ( PubMed, DOI )

Aihemaiti A, Yamamoto N, Piao J, Oyaizu T, Ochi H, Sato S, Okawa A, Miyata T, Tsuji K, Ezura Y, Asou Y. A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy Biochem Biophys Res Commun. 2021.01; 534 849-856.

Takahashi T, Sato T, Manabe J, Gokita T, Sato S, Koyanagi H. Reverse shoulder arthroplasty and synthetic mesh for reconstruction of the shoulder joint after malignant bone tumor resection: A case report Medicine Case Reports and Study Protocols. 2021.01; 2 (2): e0051.

Kobayashi Y, Tanaka T, Mulati M, Ochi H, Sato S, Kaldis P, Yoshii T, Okawa A, Inose H. Cyclin-dependent kinase1 is essential for muscle regeneration and overload muscle fiber hypertrophy Front Cell Dev Biol. 2020.10; 8 564581. ( DOI )

Kaku T, Oh Y, Sato S, Koyanagi H, Hirai T, Yuasa M, Yoshii T, Nakagawa T, Miyake S, Okawa A. Incidence of atypical femoral fractures in the treatment of bone metastasis: An alert report. J Bone Oncol. 2020.06; 23 100301.

Kawabata A, Hirai T, Tohara R, Yuasa M, Inose H, Koyanagi H, Sato S, Utagawa K, Hashimoto J, Okawa A, Yoshii T. Surgical stabilization of spinal metastasis in diffuse idiopathic skeletal hyperostosis ("Mets-on-DISH"): Two case reports. Medicine. 2020.05; 99 (22): e20397.

Minami Y, Sato S, Koyanagi H, Kinowaki Y. Malignant primary pulmonary meningioma with bone metastasis. Oxford medical case reports. 2020.02; 2020 (2): omaa005. ( PubMed, DOI )

Nagahiro S, Uehara T, Yamamoto Kawai M, Keo P, Sato T, Ochi H, Sato S, Kuroda S, Ono T, Miyashin M, Aoki K. RANKL-binding peptide promotes ectopic bone formation induced by BMP-2 gene transfer in murine gastrocnemius muscle. Dental, Oral and Maxillofacial Research. 2020.01; 6 (1): 1-6.

Mulati M, Kobayashi Y, Takahashi A, Numata H, Saito M, Hiraoka Y, Ochi H, Sato S, Ezura Y, Yuasa M, Hirai T, Yoshii T, Okawa A, Inose H. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Bone. 2020.01; 130 115076. ( PubMed, DOI )

Ozaki K, Yamada T, Horie T, Ishizaki A, Hiraiwa M, Iezaki T, Park G, Fukasawa K, Kamada H, Tokumura K, Motono M, Kaneda K, Ogawa K, Ochi H, Sato S, Kobayashi Y, Shi YB, Taylor PM, Hinoi E. The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway. Sci Signal. 2019.07; 12 (589): eaaw3921. ( PubMed, DOI )

Sopak Supakul, Kenta Yao, Hiroki Ochi, Tomohito Shimada, Kyoko Hashimoto, Satoko Sunamura, Yo Mabuchi, Miwa Tanaka, Chihiro Akazawa, Takuro Nakamura, Atsushi Okawa, Shu Takeda, Shingo Sato. Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing. Int J Mol Sci. 2019.03; 20 (5): ( PubMed, DOI )

Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M. Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice. Bio-protocol. 2019.02; 9 (3): e3151. ( PubMed, DOI )

Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Atsushi Okawa, Hiroyuki Inose. Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone. J. Biol. Chem.. 2018.12; 293 (50): 19387-19399. ( PubMed, DOI )

Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Nobuyoshi Kosaka, Yo Mabuchi, Toru Fukuda, Kenta Yao, Hiroaki Kanda, Keisuke Ae, Atsushi Okawa, Chihiro Akazawa, Takahiro Ochiya, Mitsuru Futakuchi, Shu Takeda, Shingo Sato. Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. Proc. Natl. Acad. Sci. U.S.A.. 2018.02; 115 (9): 2204-2209. ( PubMed, DOI )

Kenta Mukaihara, Yu Tanabe, Daisuke Kubota, Keisuke Akaike, Takuo Hayashi, Kaoru Mogushi, Masaki Hosoya, Shingo Sato, Eisuke Kobayashi, Taketo Okubo, Youngji Kim, Shinji Kohsaka, Tsuyoshi Saito, Kazuo Kaneko, Yoshiyuki Suehara. Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma. PLoS ONE. 2017.10; 12 (9): e0185321. ( PubMed, DOI )

Hirakawa H, Gatanaga H, Ochi H, Fukuda T, Sunamura S, Oka S, Takeda S, Sato S. Antiretroviral therapy containing HIV protease inhibitors enhances fracture risk by impairing osteoblast differentiation and bone quality JOURNAL OF INFECTIOUS DISEASES . 2017.05; 215 (12): 1893-1897. ( PubMed, DOI )

Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P,Kirsch DG, Wunder JS, Alman BA. Mesenchymal tumors can derive from Ng2/Cspg4-expressing pericytes with β-catenin modulating the neoplastic phenotype Cell Reports. 2016.07; 16 (4): 917-927. ( PubMed, DOI )

Cheng Xu, Hiroki Ochi, Toru Fukuda, Shingo Sato, Satoko Sunamura, Takeshi Takarada, Eiichi Hinoi, Atsushi Okawa, Shu Takeda. Circadian clock regulates bone resorption in mice J. Bone Miner. Res.. 2016.02; 31 (7): 1344-1355. ( PubMed, DOI )

Makoto Hirata, Shingo Sato, Jay S Wunder, Tak W. Mak, Benjamin A. Alman, etc.. Mutant IDH1 is sufficient to initiate enchondromatosis in mice Proc Natl Acad Sci USA. 2015.03; 112 (9): 2829-2834. ( PubMed )

Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J.. Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Biochem Biophys Res Commun. . 2013.01; 432 (4): 713-719.

Iwasaki M, Piao J, Kimura A, Sato S, Inose H, Ochi H, Asou Y, Shinomiya K, Okawa A, Takeda S. . Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament. PLoS One.. 2012.01; 7 (8): e43372.

Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S. . Runx1 and Runx2 cooperate during sternal morphogenesis. Development,. 2010.01; 137 (7): 1159-1167.

Inose H, Ochi H, Kimura A, Fujita K, Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K, Takeda S.. A microRNA regulatory mechanism of osteoblast differentiation. Proc. Natl. Acad. Sci. USA. . 2009.01; 106 20794-20799.

Imai Yuuki, Nakamura Takashi, Matsumoto Takahiro, Sato Shingo, Takeda Shu, Igarashi Katsubide, Yamamoto Yoko, Kanno Jun, Takayanagi Hiroshi, Takaoka Kunio, Martin T. J., Chambon Pierre, Kato Shigeaki. Sex steroids hormone mediate osteoprotecitve effects by controlling osteoclast life cycle BONE. 2008.03; 42 S37-S38. ( DOI )

Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S. . The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Arthritis Rheum. . 2008.01; S58 (9): 2764-2775.

Kimura A., Takeda S., Sato S., Iwasaki M., Inose H., Sinomiya K.. Analysis of the role of Runx1 in chondrocyte differentiation using chondrocyte-specific Runx1 deficient mice JOURNAL OF BONE AND MINERAL RESEARCH. 2007.09; 22 S100.

Takeda S., Iwasaki M., Sato S., Kimura A., Inose H., Shinomiya K.. Runx2 haploinsufficiency ameliorates the ectopic calcification in a mouse model of ossification of the Posterior Longitudinal Ligament (OPLL) JOURNAL OF BONE AND MINERAL RESEARCH. 2007.09; 22 S387.

Inose H., Takeda S., Kimura A., Sato S., Shinomiya K.. Regulation of osteoblast differentiation by MicroRNA JOURNAL OF BONE AND MINERAL RESEARCH. 2007.09; 22 S94.

Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, *Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. . Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. . 2007.01; 130 811-823.

Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M, Inose H, Ida T, Mieda M, Takeuchi Y, Fukumoto S, Fujita T, Kato S, Kangawa K, Kojima M, Shinomiya K, Takeda S. . Central control of bone remodeling by neuromedin U. Nat Med. . 2007.01; 13 1234-1240.

Takeda S, Ozdemir J, Sato S, Aso Y, Kimura A, Shinomiya G, Karsenty G. Runx1, 2 or 3 regulates chondrocyte differentiation with different efficacy and induction of Runx in intervertebral disk leads to disk degeneration. JOURNAL OF BONE AND MINERAL RESEARCH. 2005.09; 20 (9): S61.

Shingo Sato. Tumor-stromal interaction during bone metastasis.. 8th Seoul Breast Cancer 2018 2018.06.16 Seoul National University Hospital, Korea

Shingo Sato, Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda. Cancer-secreted Hsa-miR-940 Induces Osteoblastic Phenotype in the Bone Metastatic Microenvironment. Orthopaedic Research Society Annual Meeting 2018 2018.03.10 New Orleans, USA

Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Toru Fukuda, Kenta Yao, Yo Mabuchi, Atsushi Okawa, Chihiro Akazawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato. Cancer-secreted hsa-miR-940 induces osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. ERATO/AMED-CREST/PRESTO Joint International Symposium 2017.12.04 International Institute for Advanced Studies, Kyoto

Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato. Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment. American Society of Bone and Mineral Research 2017 Annual Meeting 2017.09.08 Denver, Colorado, USA

Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato. Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment. 14th Meeting of Bone Biology Forum 2017.08.18 クロスウェーブ幕張、幕張市

Shingo Sato, Yuning J. Tang, Qingxia Wei, Makoto Hirata, Ilkyu Han, Shu Takeda, David G. Kirsch, Jay S. Wunder, Benjamin A. Alman. Mesenchymal tumors can derive from NG2-expressing pericytes with beta-catenin modulating the neoplastic phenotype. Connective Tissue Oncology Society Meeting 2016 2016.11.11 Lisbon, Portugal

Shingo Sato, Qingxia Wei, Makoto Hirata, Yuning Tang, Shu Takeda, Jay S. Wunder, Benjamin Alman. Microarray and RNA sequencing analysis of pericyte-derived sarcomas in a novel sarcoma mouse model. Orthopaedic Research Society Annual Meeting 2015 2015.03.28 Las Vegas, USA

Shingo Sato, Qingxia Wei, Makoto Hirata, Yuning Tang, Shu Takeda, Jay S. Wunder, Benjamin Alman. Microarray and RNA sequencing analysis of pericyte-derived sarcomas in a novel sarcoma mouse model. Connective Tissue Oncology Society Meeting 2014 2014.10.17 Berlin

Sato S, Wei Q, Hirata M, Tang J, Wunder J, Alman B.. The pericyte as a cell of origin for sarcomas. Orthopaedic Research Society Annual Meeting 2014 2014.03.18 New Orleans, USA.

Sato S, Wei Q, Hirata M, Han I, Wunder J, Alman B. . Pericytes as the cell of origin for sarcomas and establishment of novel sarcoma mouse models. Connective Tissue Oncology Society, 18th Annual Meeting 2013.10.30 New York, USA.

Sato S, Alman B.. Pericytes as a cell of origin for sarcomas. The 8th tri-annual Combined Meeting of Orthopaedic Research Societies (CORS 2013) 2013.10.13 Venice, Italy

Sato S.. Central control of bone remodeling. The 4th International Congress of Chinese Orthopaedic Association (COA 2009) 2009.11.22 Xiamen, China

Shingo Sato, Shu Takeda, Reiko Hanada, Makiko Iwasaki, Hiroyuki Inose, Ayako Kimura, Kenji Kangawa, Masayasu Kojima, Ken-ichi Shinomiya. Central control of bone remodelling by Neuromedin U: a mediator of the leptin-dependent regulation of bone formation. The American Society for Bone and Mineral Research (ASBMR) 29th Annual Meeting 2007.09.17 Hawaii, USA.

Sato S, Takeda S, Hanada R, Iwasaki M, Kimura A, Inose H, Kojima M, Shinomiya K.. Neuromedin U regulates bone metabolism through the central nervous system independent of leptin signaling pathway. 53rd Orthopaedic Research Society 2007.02.11 San Diego, USA.