Personnel Information

写真a

NAGAI Shigenori


Job title

Associate Professor

Research Areas, Keywords

Immunology, Bacterial Infection

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 1995, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Department of Pharmacy, Master's Course, 1997.03, Completed

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Social Medicine, Doctor's Course, 2001.03, Completed

Degree 【 display / non-display

  • Ph D, The University of Tokyo

Campus Career 【 display / non-display

  • 2013.09
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Associate Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Associate Professor

External Career 【 display / non-display

  • 2001.04
    -
    2002.01
    The University of Tokyo, Department of Medicine, Project Researcher
  • 2002.02
    -
    2007.03
    Keio University, School of Medicine, assistant professor
  • 2007.04
    -
    2013.06
    Keio Universityr, School of Medicine, Assistant Professor
  • 2012.10
    -
    2019.03
    Toho University, Faculty of Science, Visiting Lecturer
  • 2013.07
    -
    2013.08
    Keio Universityr, School of Medicine, Junior Associate Professor

display all >>

Research Areas 【 display / non-display

  • Immunology

Qualification Acquired 【 display / non-display

  • Pharmacist

 

Published Papers & Misc 【 display / non-display

  • Mayuko Fujii, Nobuyuki Kawashima, Kento Tazawa, Kentaro Hashimoto, Keisuke Nara, Sonoko Noda, Masashi Kuramoto, Shion Orikasa, Shigenori Nagai, Takashi Okiji. HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells. Biochem. Biophys. Res. Commun.. 2020.02; 522 (2): 308-314. ( PubMed, DOI )

  • Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Nagai S, Okiji T.. Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells. International Endodontic Journal. 2020.01; ( DOI )

  • Nagai S, Azuma M. The CD28-B7 family of co-signaling molecules. Adv Exp Med Biol.. 2019.11; 1189 25-51. ( PubMed, DOI )

  • Xia Y, Ohno T, Nishii N, Bhingare A, Tachinami H, Kashima Y, Nagai S, Saito H, Nakae S, Azuma M. T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model. Biochem Biophys Res Commun. 2019.10; 518 (2): 331-336. ( PubMed, DOI )

  • Furusawa E, Ohno T, Nagai S, Noda T, Komiyama T, Kobayashi K, Hamamoto H, Miyashin M, Yokozeki H, Azuma M. Silencing of PD-L2/B7-DC by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. J Invest Dermatol. 2019.10; 139 (10): 2164-2173.e1. ( PubMed, DOI )

display all >>

Books etc 【 display / non-display

  • translator:Fumiko Shiroki, Shigenori Nagai . translation supervisor; Kouji Matsushima, Yukihiro Yamada. Chapter12 Effector Mechanisms of Humoral Immunity;Cellular and Molecular Immunology,Seventh Edition. Elsevier, 2014.11 Effector Mechanisms of Humoral Immunity

Conference Activities & Talks 【 display / non-display

  • Yang Y, Nagai S, Azuma M. Repeated antigen painting induces tolerogenic cells in sublingual mucosa. 17th IUIS 2019 (International Congress of Immunology) 2019.10.19 Beijing, China

  • Kagami S, Kizukuri R, Nagai S, Aizawa M. Responses of immune cells to hydroxyapatite ceramics loaded with immunostimulators. 30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine 2018.10.26

  • Nakagawa D, Kizukuri R, Kagami S, Nagai S, Aizawa M. Fabrication of boron-containing apatite ceramics by reaction sintering method and their cellular responses of immunocytes. 15th International Symposium on Dendritic Cells 2018.06.10 Bandung, Indonesia

  • Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  • Nagai S,Kurebayashi Y. Phosphorylation of Akt and Foxos induced by TGF-β negatively controls the differentiation of induced regulatory T cells. The 37th Annual Meeting of The Molecular Biology Society of Japan 2014.11.25

display all >>

Patents 【 display / non-display

  • CARRIER

    Patent Number: 5145700