Personnel Information

写真a

NAGAI Shigenori


Job title

Associate Professor

Research Areas, Keywords

Immunology, Bacterial Infection
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Pharmaceutical Science, 1995, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Department of Pharmacy, Master's Course, 1997.03, Completed

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Social Medicine, Doctor's Course, 2001.03, Completed

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Degree 【 display / non-display 】

  • Ph D, The University of Tokyo

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Campus Career 【 display / non-display 】

  • 2013.09
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Molecular Immunology， Associate Professor
  • 2018.04
    -
    2024.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Molecular Immunology， Associate Professor
  • 2024.08
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Oral Health Sciences， -， Associate Professor
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External Career 【 display / non-display 】

  • 2001.04
    -
    2002.01
    The University of Tokyo, Department of Medicine, Project Researcher
  • 2002.02
    -
    2007.03
    Keio University, School of Medicine, assistant professor
  • 2007.04
    -
    2013.06
    Keio Universityr, School of Medicine, Assistant Professor
  • 2012.10
    -
    2019.03
    Toho University, Faculty of Science, Visiting Lecturer
  • 2013.07
    -
    2013.08
    Keio Universityr, School of Medicine, Junior Associate Professor
  • 2015.04
    -
    2016.03
    , Visiting Lecturer

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Research Areas 【 display / non-display 】

  • Immunology

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Qualification Acquired 【 display / non-display 】

  • Pharmacist

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Published Papers & Misc 【 display / non-display 】

  1. Daroonpan P, Ouchi R, Zhang C, Nagai S, Nishii N, Kashima Y, Tsushima F, Harada H, Hamagaki M, Ikeda T, Aida J, Kaomongkolgit R, Azuma M. Personal immune profiles: Diversity and prognostic value for oral tongue squamous cell carcinoma evaluated by comprehensive immune parameter analyses with multiplex immunofluorescence. Oral oncology. 2023.08; 143 106458. ( PubMed, DOI )

  2. Namangkalakul W, Nagai S, Jin C, Nakahama KI, Yoshimoto Y, Ueha S, Akiyoshi K, Matsushima K, Nakashima T, Takechi M, Iseki S.. Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization Journal of Tissue Engineering. 2023.07; 14 20417314231187960. ( PubMed, DOI )

  3. Wongtim K, Ikeda E, Ohno T, Nagai S, Okuhara S, Kure K, Azuma M. Overexpression of PD-L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature-induced periodontitis model. J Periodontol. 2022.01; 93 (1): 146-155. ( PubMed, DOI )

  4. Ao X, Yang Y, Okiji T, Azuma M, Nagai S. Polymorphonuclear Myeloid-derived cells that contribute to the immune paralysis are generated in the early phase of sepsis via PD-1/PD-L1 pathway. Infection and Immunity. 2021.05; 89 (6): e00771-20. ( PubMed, DOI )

  5. Ishihama H, Ishii K, Nagai S, Kakinuma H, Sasaki A, Yoshioka K, Kuramoto T, Shiono Y, Funao H, Isogai N, Tsuji T, Okada Y, Koyasu S, Toyama Y, Nakamura M, Aizawa M, Matsumoto M. An antibacterial coated polymer prevents biofilm formation and implant-associated infection. Scientific Reports. 2021.02; 11 (1): 3602. ( PubMed, DOI )

  6. Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker BL, Timmer MSM, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S. Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors. Journal of Experimental Medicine. 2021.01; 218 (1): e20200815. ( PubMed, DOI )

  7. Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. International Immunology. 2020.08; 32 (8): 509-518. ( PubMed, DOI )

  8. Kashima Y, Nishii N, Tachinami H, Furusawa E, Nagai S, Harada H, Azuma M. Orthotopic tongue squamous cell carcinoma (SCC) model exhibiting a different tumor-infiltrating T-cell status with margin-restricted CD8 + T cells and regulatory T cell-dominance, compared to skin SCC. Biochem Biophys Res Commun.. 2020.05; 526 (1): 218-224. ( PubMed, DOI )

  9. Mayuko Fujii, Nobuyuki Kawashima, Kento Tazawa, Kentaro Hashimoto, Keisuke Nara, Sonoko Noda, Masashi Kuramoto, Shion Orikasa, Shigenori Nagai, Takashi Okiji. HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells. Biochem. Biophys. Res. Commun.. 2020.02; 522 (2): 308-314. ( PubMed, DOI )

  10. Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Nagai S, Okiji T. Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells International Endodontic Journal. 2020.01; ( DOI )

  11. Nakagawa D, Nakamura M, Nagai S, Aizawa M. Fabrications of boron-containing apatite ceramics via ultrasonic spray-pyrolysis route and their responses to immunocytes J Mater Sci Mater Med.. 2020.01; 31 (2): 20. ( PubMed, DOI )

  12. Nagai S, Azuma M. The CD28-B7 family of co-signaling molecules. Adv Exp Med Biol.. 2019.11; 1189 25-51. ( PubMed, DOI )

  13. Furusawa E, Ohno T, Nagai S, Noda T, Komiyama T, Kobayashi K, Hamamoto H, Miyashin M, Yokozeki H, Azuma M. Silencing of PD-L2/B7-DC by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. J Invest Dermatol. 2019.10; 139 (10): 2164-2173.e1. ( PubMed, DOI )

  14. Xia Y, Ohno T, Nishii N, Bhingare A, Tachinami H, Kashima Y, Nagai S, Saito H, Nakae S, Azuma M.. Endogenous IL-33 exerts CD8 + T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model Biochem Biophys Res Commun.. 2019.10; 518 (2): 331-336. ( PubMed, DOI )

  15. Tachinami H, Nishii N, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Tomihara K, Noguchi M, Azuma M. Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade. Oral Oncology. 2019.04; 91 21-28. ( PubMed, DOI )

  16. Kagami S, Kizukuri R, Nagai S, *Aizawa M.. Responses of Immune Cells to Hydroxyapatite Ceramics Loaded with Immunostimulators. J Soc Inorg Mater Jpn.. 2019.03; 26 (399): 74-81.

  17. Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. Oncotarget. 2018.03; 9 (17): 13301-13312. ( PubMed, DOI )

  18. Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.11; 152 (3): 507-516. ( PubMed, DOI )

  19. Yutaka Kurebayashi, Yukiko Baba, Akiko Minowa, Niken Adiba Nadya, Miyuki Azuma, Akihiko Yoshimura, Shigeo Koyasu, Shigenori Nagai. TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation. Biochem. Biophys. Res. Commun.. 2016.11; 480 (1): 114-119. ( PubMed, DOI )

  20. Yuta Shiono, Ken Ishii, Shigenori Nagai, Hiroaki Kakinuma, Aya Sasaki, Haruki Funao, Tetsuya Kuramoto, Kenji Yoshioka, Hiroko Ishihama, Norihiro Isogai, Kenichiro Takeshima, Takashi Tsuji, Yasunori Okada, Shigeo Koyasu, Masaya Nakamura, Yoshiaki Toyama, Mamoru Aizawa, Morio Matsumoto. Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant. Sci Rep. 2016.09; 6 32758. ( PubMed, DOI )

  21. Yusuke Yamazumi, Oh Sasaki, Mitsuru Imamura, Takeaki Oda, Yoko Ohno, Yumi Shiozaki-Sato, Shigenori Nagai, Saki Suyama, Yuki Kamoshida, Kosuke Funato, Teruhito Yasui, Hitoshi Kikutani, Kazuhiko Yamamoto, Makoto Dohi, Shigeo Koyasu, Tetsu Akiyama. The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation. Cell Rep. 2016.08; 16 (9): 2456-2471. ( PubMed, DOI )

  22. Haruki Funao, Shigenori Nagai, Aya Sasaki, Tomoyuki Hoshikawa, Takashi Tsuji, Yasunori Okada, Shigeo Koyasu, Yoshiaki Toyama, Masaya Nakamura, Mamoru Aizawa, Morio Matsumoto, Ken Ishii. A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection. Sci Rep. 2016.03; 6 23238. ( PubMed, DOI )

  23. Kenji Yoshioka, Ken Ishii, Tetsuya Kuramoto, Shigenori Nagai, Haruki Funao, Hiroko Ishihama, Yuta Shiono, Aya Sasaki, Mamoru Aizawa, Yasunori Okada, Shigeo Koyasu, Yoshiaki Toyama, Morio Matsumoto. A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS ONE. 2014.09; 9 (9): e106367. ( PubMed, DOI )

  24. Muhammad Baghdadi, Akihiro Yoneda, Tsunaki Yamashina, Hiroko Nagao, Yoshihiro Komohara, Shigenori Nagai, Hisaya Akiba, Marc Foretz, Hironori Yoshiyama, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Motohiro Takeya, Benoit Viollet, Hideo Yagita, Masahisa Jinushi. TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity. 2013.12; 39 (6): 1070-1081. ( PubMed, DOI )

  25. Ryuichi Murakami, Kaori Denda-Nagai, Shin-ichi Hashimoto, Shigenori Nagai, Masahira Hattori, Tatsuro Irimura. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013.09; 8 (9): e73270. ( PubMed, DOI )

  26. Hideyuki Yoshida, Hitoshi Kotani, Taisuke Kondo, Ito Tani, Xuetao Wei, Sanae Tsuruta, Akihiro Kimura, Mayako Asakawa, Minako Ito, Shigenori Nagai, Akihiko Yoshimura. CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice. Biochem. Biophys. Res. Commun.. 2013.06; 435 (3): 378-384. ( PubMed, DOI )

  27. Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Shigeo Koyasu. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells. 2013.04; 18 (4): 247-265. ( PubMed, DOI )

  28. Shigenori Nagai, Yutaka Kurebayashi, Shigeo Koyasu. Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation. Ann. N. Y. Acad. Sci.. 2013.03; 1280 30-34. ( PubMed, DOI )

  29. Daisuke Sugiura, Kaori Denda-Nagai, Mitsuyo Takashima, Ryuichi Murakami, Shigenori Nagai, Kazuyoshi Takeda, Tatsuro Irimura. Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo. PLoS ONE. 2012.07; 7 (9): e44770. ( PubMed, DOI )

  30. Akihiro Yoshizawa, Shigenori Nagai, Yukiko Baba, Taketo Yamada, Minoru Matsui, Hikaru Tanaka, Shun-ichiro Miyoshi, Masayuki Amagai, Tsutomu Yoshikawa, Keiichi Fukuda, Satoshi Ogawa, Shigeo Koyasu. Autoimmunity against M₂muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. Eur. J. Immunol.. 2012.05; 42 (5): 1152-1163. ( PubMed, DOI )

  31. Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. Cell Rep. 2012.04; 1 (4): 360-373. ( PubMed, DOI )

  32. Ai Ikejiri, Shigenori Nagai, Nobuhito Goda, Yutaka Kurebayashi, Mayuko Osada-Oka, Keiyo Takubo, Toshio Suda, Shigeo Koyasu. Dynamic regulation of Th17 differentiation by oxygen concentrations. Int. Immunol.. 2012.03; 24 (3): 137-146. ( PubMed, DOI )

  33. Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Yuichiro Maekawa, Kotaro Naito, Hidehiro Kaneko, Yasuo Sugano, Toshiyuki Takahashi, Hitoshi Abe, Satsuki Mochizuki, Motoaki Sano, Tsutomu Yoshikawa, Yasunori Okada, Shigeo Koyasu, Satoshi Ogawa, Keiichi Fukuda. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation. 2012.03; 125 (10): 1234-1245. ( PubMed, DOI )

  34. Kouji Matsushima, Shigenori Nagai. Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection. J. Clin. Invest.. 2012.03; 122 (3): 801-804. ( PubMed, DOI )

  35. Haruki Funao, Ken Ishii, Shigenori Nagai, Aya Sasaki, Tomoyuki Hoshikawa, Mamoru Aizawa, Yasunori Okada, Kazuhiro Chiba, Shigeo Koyasu, Yoshiaki Toyama, Morio Matsumoto. Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging. Infect. Immun.. 2012.02; 80 (2): 733-741. ( PubMed, DOI )

  36. Sayuri Chiba, Takeshi Nagai, Toshiyuki Hayashi, Yukiko Baba, Shigenori Nagai, Shigeo Koyasu. Listerial invasion protein internalin B promotes entry into ileal Peyer's patches in vivo. Microbiol. Immunol.. 2011.02; 55 (2): 123-129. ( PubMed, DOI )

  37. Kanna Nagamatsu, Asaomi Kuwae, Tadashi Konaka, Shigenori Nagai, Sei Yoshida, Masahiro Eguchi, Mineo Watanabe, Hitomi Mimuro, Shigeo Koyasu, Akio Abe. Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN. J. Exp. Med.. 2009.12; 206 (13): 3073-3088. ( PubMed, DOI )

  38. Masahisa Jinushi, Marimo Sato, Akira Kanamoto, Akihiko Itoh, Shigenori Nagai, Shigeo Koyasu, Glenn Dranoff, Hideaki Tahara. Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. J. Exp. Med.. 2009.06; 206 (6): 1317-1326. ( PubMed, DOI )

  39. Tamiko Matsui, Norihito Nakata, Shigenori Nagai, Akira Nakatani, Miwako Takahashi, Toshimitsu Momose, Kuni Ohtomo, Shigeo Koyasu. Inflammatory cytokines and hypoxia contribute to 18F-FDG uptake by cells involved in pannus formation in rheumatoid arthritis. J. Nucl. Med.. 2009.06; 50 (6): 920-926. ( PubMed, DOI )

  40. Toshiyuki Hayashi, Shigenori Nagai, Hideki Fujii, Yukiko Baba, Eiji Ikeda, Takeshi Kawase, Shigeo Koyasu. Critical roles of NK and CD8+ T cells in central nervous system listeriosis. J. Immunol.. 2009.05; 182 (10): 6360-6368. ( PubMed, DOI )

  41. Masato Suzuki, Hitomi Mimuro, Kotaro Kiga, Makoto Fukumatsu, Nozomi Ishijima, Hanako Morikawa, Shigenori Nagai, Shigeo Koyasu, Robert H Gilman, Dangeruta Kersulyte, Douglas E Berg, Chihiro Sasakawa. Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. Cell Host Microbe. 2009.01; 5 (1): 23-34. ( PubMed, DOI )

  42. Yumi Sawatani, Takeshi Miyamoto, Shigenori Nagai, Mikako Maruya, Jun Imai, Kana Miyamoto, Nobuyuki Fujita, Ken Ninomiya, Toru Suzuki, Ryotaro Iwasaki, Yoshiaki Toyama, Masanori Shinohara, Shigeo Koyasu, Toshio Suda. The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int. Immunol.. 2008.10; 20 (10): 1259-1268. ( PubMed, DOI )

  43. Masashi Ohtani, Shigenori Nagai, Shuhei Kondo, Shinta Mizuno, Kozue Nakamura, Masanobu Tanabe, Tsutomu Takeuchi, Satoshi Matsuda, Shigeo Koyasu. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood. 2008.08; 112 (3): 635-643. ( PubMed, DOI )

  44. Yuichi Itoh, Mika Kamata-Sakurai, Kaori Denda-Nagai, Shigenori Nagai, Makoto Tsuiji, Katrin Ishii-Schrade, Kyoko Okada, Akiteru Goto, Masashi Fukayama, Tatsuro Irimura. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. Glycobiology. 2008.01; 18 (1): 74-83. ( PubMed, DOI )

  45. Hitomi Mimuro, Toshihiko Suzuki, Shigenori Nagai, Gabriele Rieder, Masato Suzuki, Takeshi Nagai, Yukihiro Fujita, Kanna Nagamatsu, Nozomi Ishijima, Shigeo Koyasu, Rainer Haas, Chihiro Sasakawa. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe. 2007.10; 2 (4): 250-263. ( PubMed, DOI )

  46. Shigenori Nagai, Hitomi Mimuro, Taketo Yamada, Yukiko Baba, Kazuyo Moro, Tomonori Nochi, Hiroshi Kiyono, Toshihiko Suzuki, Chihiro Sasakawa, Shigeo Koyasu. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc. Natl. Acad. Sci. U.S.A.. 2007.05; 104 (21): 8971-8976. ( PubMed, DOI )

  47. Yimin Yu, Shigenori Nagai, Huixia Wu, Andrew S Neish, Shigeo Koyasu, Andrew T Gewirtz. TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J. Immunol.. 2006.05; 176 (10): 6194-6201. ( PubMed )

  48. Atsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi, Chiharu Sadamitsu, Hideki Nishitoh, Shigenori Nagai, Shigeo Koyasu, Kunihiro Matsumoto, Kohsuke Takeda, Hidenori Ichijo. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol.. 2005.06; 6 (6): 587-592. ( PubMed, DOI )

  49. Kazushi Motomura, Nobuaki Toyoda, Kazunori Oishi, Hironori Sato, Shigenori Nagai, Shin-ichi Hashimoto, Sitefano Buguruka Tugume, Richard Enzama, Roy Mugewa, Cissy Kityo Mutuluuza, Peter Mugyeyi, Tsuyoshi Nagatake, Kouji Matsushima. Identification of a host gene subset related to disease prognosis of HIV-1 infected individuals. Int. Immunopharmacol.. 2004.12; 4 (14): 1829-1836. ( PubMed, DOI )

  50. Nobuaki Toyoda, Shigenori Nagai, Yuya Terashima, Kazushi Motomura, Makoto Haino, Shin-ichi Hashimoto, Hajime Takizawa, Kouji Matsushima. Analysis of mRNA with microsomal fractionation using a SAGE-based DNA microarray system facilitates identification of the genes encoding secretory proteins. Genome Res.. 2003.07; 13 (7): 1728-1736. ( PubMed, DOI )

  51. Shin-ichi Hashimoto, Shigenori Nagai, Jun Sese, Takuji Suzuki, Aya Obata, Taku Sato, Nobuaki Toyoda, Hong-Yan Dong, Makoto Kurachi, Tomoyuki Nagahata, Ken-ichi Shizuno, Shinichi Morishita, Kouji Matsushima. Gene expression profile in human leukocytes. Blood. 2003.05; 101 (9): 3509-3513. ( PubMed, DOI )

  52. Aya Obata-Onai, Shin-ichi Hashimoto, Nobuyuki Onai, Makoto Kurachi, Shigenori Nagai, Ken-ichi Shizuno, Tomoyuki Nagahata, Kouji Matsushima, Kouji Mathushima. Comprehensive gene expression analysis of human NK cells and CD8(+) T lymphocytes. Int. Immunol.. 2002.10; 14 (10): 1085-1098. ( PubMed )

  53. Hidekuni Inadera, Shigenori Nagai, Hong-Yan Dong, Kouji Matsushima. Molecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model. Int. J. Cancer. 2002.09; 101 (1): 37-45. ( PubMed, DOI )

  54. Sho Ishikawa, Shigenori Nagai, Taku Sato, Kenji Akadegawa, Hiroyuki Yoneyama, Yan-Yun Zhang, Nobuyuki Onai, Kouji Matsushima. Increased circulating CD11b+CD11c+ dendritic cells (DC) in aged BWF1 mice which can be matured by TNF-alpha into BLC/CXCL13-producing DC. Eur. J. Immunol.. 2002.07; 32 (7): 1881-1887. ( PubMed, DOI )

  55. Nobuaki Higashi, Kouki Fujioka, Kaori Denda-Nagai, Shin-Ichi Hashimoto, Shigenori Nagai, Taku Sato, Yuko Fujita, Akiko Morikawa, Makoto Tsuiji, Megumi Miyata-Takeuchi, Yoshihiko Sano, Noriko Suzuki, Kazuo Yamamoto, Kouji Matsushima, Tatsuro Irimura. The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. J. Biol. Chem.. 2002.06; 277 (23): 20686-20693. ( PubMed, DOI )

  56. Makoto Kurachi, Shin-ichi Hashimoto, Aya Obata, Shigenori Nagai, Tomoyuki Nagahata, Hidekuni Inadera, Hideko Sone, Chiharu Tohyama, Shuichi Kaneko, Ken-ichi Kobayashi, Kouji Matsushima. Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive genes in mouse liver by serial analysis of gene expression. Biochem. Biophys. Res. Commun.. 2002.03; 292 (2): 368-377. ( PubMed, DOI )

  57. S Ishikawa, T Sato, M Abe, S Nagai, N Onai, H Yoneyama, Y Zhang, T Suzuki, S Hashimoto, T Shirai, M Lipp, K Matsushima. Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. J. Exp. Med.. 2001.06; 193 (12): 1393-1402. ( PubMed )

  58. S Nagai, S Hashimoto, T Yamashita, N Toyoda, T Satoh, T Suzuki, K Matsushima. Comprehensive gene expression profile of human activated T(h)1- and T(h)2-polarized cells. Int. Immunol.. 2001.03; 13 (3): 367-376. ( PubMed )

  59. T Yamashita, S Kaneko, S Hashimoto, T Sato, S Nagai, N Toyoda, T Suzuki, K Kobayashi, K Matsushima. Serial analysis of gene expression in chronic hepatitis C and hepatocellular carcinoma. Biochem. Biophys. Res. Commun.. 2001.03; 282 (2): 647-654. ( PubMed, DOI )

  60. M Itakura, A Tokuda, H Kimura, S Nagai, H Yoneyama, N Onai, S Ishikawa, T Kuriyama, K Matsushima. Blockade of secondary lymphoid tissue chemokine exacerbates Propionibacterium acnes-induced acute lung inflammation. J. Immunol.. 2001.02; 166 (3): 2071-2079. ( PubMed )

  61. T Suzuki, S Hashimoto, N Toyoda, S Nagai, N Yamazaki, H Y Dong, J Sakai, T Yamashita, T Nukiwa, K Matsushima. Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE. Blood. 2000.10; 96 (7): 2584-2591. ( PubMed )

  62. S I Hashimoto, T Suzuki, S Nagai, T Yamashita, N Toyoda, K Matsushima. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood. 2000.09; 96 (6): 2206-2214. ( PubMed )

  63. H Inadera, S Hashimoto, H Y Dong, T Suzuki, S Nagai, T Yamashita, N Toyoda, K Matsushima. WISP-2 as a novel estrogen-responsive gene in human breast cancer cells. Biochem. Biophys. Res. Commun.. 2000.08; 275 (1): 108-114. ( PubMed, DOI )

  64. T Yamashita, S Hashimoto, S Kaneko, S Nagai, N Toyoda, T Suzuki, K Kobayashi, K Matsushima. Comprehensive gene expression profile of a normal human liver. Biochem. Biophys. Res. Commun.. 2000.03; 269 (1): 110-116. ( PubMed, DOI )

  65. S Hashimoto, T Suzuki, H Y Dong, S Nagai, N Yamazaki, K Matsushima. Serial analysis of gene expression in human monocyte-derived dendritic cells. Blood. 1999.08; 94 (3): 845-852. ( PubMed )

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Books etc 【 display / non-display 】

  1. Shigenori Nagai and Miyuki Azuma. Co-signal Molecules in T Cell Activation. Springer， 2019 The CD28-B7 Family of Co-signaling Molecules (ISBN : 978-981-32-9716-6)

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Conference Activities & Talks 【 display / non-display 】

  1. Chenyang Zhang, Yi Lu, Shigenori Nagai, Miyuki Azuma.. Alternation of anti-tumor responses and PD-L1 blockade.. The 1st International Symposium on Cancer Immunology and Immunotherapy. 2024.03.24

  2. Farzana Sultana, Chenyang Zhang, Miyuki Azuma, Shigenori Nagai.. A new immune checkpoint molecule ILDR2 expression on CD206+ macrophages is enhanced after repeated antigen-painting onto sublingual mucosa.. 第52回日本免疫学会総会・学術集会 2024.01.18

  3. １． Yundi Zheng, Masato Nose, Ryuichi Fukuda, Shigenori Nagai, Mamoru Aizawa.. Fabrication of boron-containing apatite ceramics via reaction sintering process and their immune functions.. 20th Asian Bioceramics Symposium. 2022.12.11 Toyama International Conference Center

  4. W Namangkalakul, S Nagai, K Nakahama, M Takechi, S Iseki. Fibroblast growth factor 18 Activity on Calvarial Bone Regeneration. The 2021 IADR/AADR/CADR General Session & Exhibition 2021.07.21 U.S.A. (Web)

  5. 敖　翔、東　みゆき、永井　重徳．. ザイモザン誘導性免疫麻痺モデルにおけるPD-1/PD-L1経路の役割. 第62回歯科基礎医学会 2020.09.11 鹿児島(Web)

  6. 永井 重徳，ヤン ユエ，東 みゆき. 抗原反復塗布により舌下粘膜に現れるCD206 陽性マクロファージの免疫 寛容特性. 第62回歯科基礎医学会 2020.09.11 鹿児島(Web)

  7. Wongtim Keeratika、永井　重徳、奥原　滋、東　みゆき.. 免疫チェックポイント分子PD-L1の歯肉過剰発現は、早期および慢性の歯肉炎症を抑制する.. 第62回歯科基礎医学会 2020.09.11 鹿児島(Web)

  8. Widyagarini Amrita、永井　重徳、東　みゆき.. Binding and functional properties of VSIG4(V-set and Ig domain containing 4)-Ig fusion protein.. 第62回歯科基礎医学会 2020.09.11 鹿児島(Web)

  9. Wongtim Keeratika、池田　恵莉、大野　建州、永井　重徳、奥原　滋、呉　圭哲、東　みゆき.. 免疫チェックポイント分子PD-L1の歯肉過剰発現は、早期および慢性の歯肉炎症を抑制する.. 第74回日本口腔科学会 2020.04.15 新潟(Web)

  10. Yang Y, Nagai S, Azuma M. Repeated antigen painting induces tolerogenic cells in sublingual mucosa. 17th IUIS 2019 (International Congress of Immunology) 2019.10.19 Beijing, China

  11. Nakagawa D, Kizukuri R, Kagami S, Nagai S, Aizawa M. Fabrication of boron-containing apatite ceramics by reaction sintering method and their cellular responses of immunocytes. 15th International Symposium on Dendritic Cells 2018.06.10 Bandung, Indonesia

  12. Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  13. Yamada K, Nakamura M, Nagai S, Honda M, Aizawa M. Cellular Responses of Immune Cells Derived from Mouse Spleen to Hydroxyapatite Ceramics Surface-modified with Inositol Phosphate. 26th Symphosium and Annual Meeting of the International Society for Ceramics in Medicine 2014.11.06 Barcelona, Italy

  14. Takeya Adachi, Kazuyo Moro, Shigenori Nagai, Masayuki Amagai, Keisuke Nagao. Resident memory T cells in epidermis require hair follicle-derived cytokines for survival. 第42回日本免疫学会総会・学術集会 2013.12.13 幕張

  15. Shigenori Nagai, Akihiro Yoshizawa, et al. The pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice. 第42回日本免疫学会総会・学術集会 2013.12.11 幕張

  16. Akihiro Yoshizawa, Shigenori Nagai, et al. Development of pulmonary alveolar proteinosis in PI3K deficient mice. The Joint International Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophages 2013 2013.05.20 Tokyo

  17. Midori Iso, Shigenori Nagai, et al. Role of TLRs in the induction of collagen-induced arthritis. 第41回日本免疫学会総会・学術集会 2012.12.07 神戸

  18. ３． Baghdadi Muhammad, Shigeki Chiba, Hisaya Akiba, Hideo Yagita, Shigenori Nagai, Masahisa Jinushi. TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms. 第41回日本免疫学会総会・学術集会 2012.12.05 神戸

  19. Masahiro Nagata, Michio Shimamura, Eri Ishikawa, Shigenori Nagai, Shigeo Koyasu, Sho Yamasaki. Recognition of amphiphilic acylglucoside derived from Helicobacter pylori by C-type lectin receptor Mincle. 第41回日本免疫学会総会・学術集会 2012.12.05 神戸

  20. Midori Iso, Shigenori Nagai, et al. Role of TLRs in the induction of collagen-induced arthritis. The 12th International Symposium on Dendritic Cells 2012.10.08 Daegu, Korea

  21. Shigenori Nagai, et al. PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation. Inositol Phospholipid Signaling in Physiology and Disease, New York Academy of Sciences 2012.06.26 New York City

  22. Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, et al. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. 20th International Symposium on Molecular Cell Biology of Macrophages 2012.06.15 Tokyo

  23. Shigenori Nagai, Yutaka Kurebayashi, et al. PI3K-Akt-mTORC1 axis controls Th17 differentiation by regulation of Gfi-1 and RORγt. 第40回日本免疫学会総会・学術集会 2011.11.28 幕張

  24. Ai Ikejiri, Shigenori Nagai, et al. HIF-1aplha regulates the differentiation of Th17 cells primed under hypoxia. 第40回日本免疫学会総会・学術集会 2011.11.28 幕張

  25. Shigenori Nagai, Shigeo Koyasu. Role of PI3K-Akt-mTORC1 axis on Th17 differentiation during Helicobacter pylori infection. International Union of Microbiological Societies 2011 Congress 2011.09.08 札幌コンベンションセンター

  26. Shigenori Nagai, Ryosuke Katori, et al. Establishment of a novel collagen-induced arthritis model by DC-manipulation. The Joint International Meeting Sponsored by The 76th Annual Meeting of the Japanese Society for Interferon and Cytokine & The 19th International Symposium on Molecular Cell Biology of Macrophages 2011 2011.05.25 Osaka

  27. Shigenori Nagai, Ryosuke Katori, et al. Establishment of a novel collagen-induced arthritis model by manipulating dendritic cells. The 11th International Symposium on Dendritic Cells 2010.09.28 Lugano, Switzerland

  28. Shigenori Nagai, Yutaka Kurebayashi, et al. Role of phosphoinositide 3-kinase on helper T cell differentiation in Helicobacter pylori-induced gastritis. 14th International Congress of Immunology 2010.08.25 神戸

  29. Ryosuke Katori, Munenori Oyama, Shigenori Nagai, et al. Establishment of a novel collagen-induced arthritis model by manipulating dendritic cells. 14th International Congress of Immunology 2010.08.24 Kobe

  30. Sayuri Chiba, Shigenori Nagai, et al. Role of Internalin B in the gastrointestinal infection with Listeria monocytogenes. 第39回日本免疫学会総会・学術集会 2009.12.04 大阪

  31. Yutaka Kurebayashi, Shigenori Nagai, et al. PI3K-Akt-mTOR-dependent but Foxp3-independent pathway selectively upregulates Th17 cell differentiation. 第39回日本免疫学会総会・学術集会 2009.12.02 大阪

  32. Yutaka Kurebayashi, Shigenori Nagai, et al. Th17 cell differentiation is positively controlled by PI3K/Akt signaling. The 9th World Congress on Inflammation 2009.07.06 Tokyo

  33. Haruki Funao, Ken Ishii, Shigenori Nagai, et al. Establishment of quantitative model of staphylococcal osteomyelitis using bioimaging techniques. The 9th World Congress on Inflammation 2009.07.06 Tokyo

  34. Toshiyuki Hayashi, Shigenori Nagai, et al. Critical Roles of NK and CD8+ T cells in central nervous system listeriosis. 17th International Symposium on Molecular Cell Biology of Macrophages 2009 2009.07.03 Kanazawa

  35. Shigenori Nagai. The role of helper T cells in Helicobacter pylori-induced gastritis. GI Executive Meeting 2009 2009.06.19 京都

  36. Toshiyuki Hayashi, Shigenori Nagai, et al. Roles of IFNγ and IL-17 on CNS listeriosis. 第38回日本免疫学会総会・学術集会 2008.12.03 京都

  37. Shigenori Nagai, et al. Role of IL-17A in Helicobacter pylori-induced gastritis. 第38回日本免疫学会総会・学術集会 2008.12.01 京都

  38. Yutaka Kurebayashi, Shigenori Nagai, et al. Role of class IA PI3K in Th17 differentiation. 第38回日本免疫学会総会・学術集会 2008.12.01 京都

  39. Shigenori Nagai, Chigusa Iyama, et al. Role of phosphoinositide 3-kinase on type I interferon production by plasmacytoid dendritic cells. The 10th International Symposium on Dendritic Cells 2008.10.03 Kobe

  40. Toshiyuki Hayashi, Shigenori Nagai, et al. Analysis of functions of T cells on CNS listeriosis. 第37回日本免疫学会総会・学術集会 2007.11.22 東京

  41. Kazuyo Moro, Taketo Yamada, Hideki Fujii, Yukiko Baba, Shigenori Nagai, Shigeo Koyasu. Identification of lymphoid progenitors in the mesenterium of adult mice. 第37回日本免疫学会総会・学術集会 2007.11.22 大阪

  42. Shigenori Nagai, Hitomi Mimuro, et al. The role of coccoid form of Helicobacter pylori on the induction of gastritis. 第36回日本免疫学会総会・学術集会 2006.12.13 大阪

  43. Toshiyuki Hayashi, Shigenori Nagai, et al. The role of acquired immunity on CNS listeriosis. 第36回日本免疫学会総会・学術集会 2006.12.13 大阪

  44. Shuhei Kondo, Satoshi Matsuda, Shigenori Nagai, et al. The role of mTOR in TLRs-induced IL-12 production by dendritic cells. 第36回日本免疫学会総会・学術集会 2006.12.13 大阪

  45. Masashi Ohtani, Satoshi Matsuda, Shigenori Nagai, et al. The mammalian target of rapamycin (mTOR) is involved in LPS-induced IL-12 production in dendritic cells. 15th International Symposium on Molecular Cell Biology of Macrophages 2006 2006.06.09 Tokyo

  46. Shigenori Nagai, Chigusa Tanaka-Iyama, et al. The role of PI3K on cytokine production by plasmacytoid dendritic cells. 15th International Symposium on Molecular Cell Biology of Macrophages 2006 2006.06.09 Tokyo

  47. Shigenori Nagai, et al. T lymphocyte-mediated induction of inflammatory response in the gastric mucosa in Helicobacter pylori infection. 第35回日本免疫学会総会・学術集会 2005.12.14 横浜

  48. Chigusa Iyama, Shigenori Nagai, et al. The role of PI3K on cytokine production by plasmacytoid dendritic cells. 第35回日本免疫学会総会・学術集会 2005.12.14 横浜

  49. Shigenori Nagai, et al. PI3K-mTOR pathway negatively regulates interleukin-12 production by dendritic cells. 第34回日本免疫学会総会・学術集会 2004.12.02 札幌

  50. Akihiro Yoshizawa, Shigenori Nagai, et al. Experimental autoimmune myocarditis and myocardial dysfunction induced by autoantibody against muscarinic acetylcholine receptor type 2 in mice. 第34回日本免疫学会総会・学術集会 2004.12.02 札幌

  51. Shigenori Nagai, Shinta Mizuno, et al. Effect of rapamycin on IL-12 production by DCs. 12th International Congress of Immunology 2004.07.20 Montreal, Canada

  52. Shigenori Nagai, Shinta Mizuno, et al. Effect of rapamycin on interleukin-12 production by dendritic cells. 13th International Symposium on Molecular Cell Biology of Macrophages 2004 2004.07.01 Osaka

  53. Shigenori Nagai, Taketo Yamada, et al. Role of PI3K in immune response of Helicobacter pylori infection. 第33回日本免疫学会総会・学術集会 2003.12.08 福岡

  54. Shigenori Nagai, Shinichi Hashimoto, et al. SAGE (Serial Analysis of Gene Expression) 法によるヒト活性化Th1及びTh2細胞の遺伝子発現解析. 第30回日本免疫学会総会・学術集会 2000.11.15 仙台

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