Personnel Information

写真a

OSHIMA Shigeru


Job title

Professor

Birth date

1972

Mail Address

The inquiry by e-mail is 《here》
To the head of this page.▲

Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 1997, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2004, Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2011.10
    -
    2013.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Endowed Departments， Department of Advanced Therapeutics for GI Diseases， Assistant Professor
  • 2013.04
    -
    2015.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Assistant Professor
  • 2015.08
    -
    2018.04
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Assistant Professor
  • 2018.05
    -
    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Junior Associate Professor
  • 2019.11
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Gastroenterology and Hepatology， Junior Associate Professor
  • 2021.10
    -
    2022.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Gastroenterology and Hepatology， Junior Associate Professor
  • 2022.04
    　
    　
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Gastroenterology and Hepatology， Junior Associate Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， Young Investigator Support Center， Professor

▼display all

To the head of this page.▲

External Career 【 display / non-display 】

  • , Senior Resident
To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  1. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  2. Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647 72-79. ( PubMed, DOI )

  3. Minamidate A, Onizawa M, Saito C, Hikichi R, Mochimaru T, Murakami M, Sakuma C, Asakawa T, Hiraoka Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, Okamoto R, Watanabe M. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochemistry and biophysics reports. 2021.09; 27 101065. ( PubMed, DOI )

  4. Asakawa Takehito, Onizawa Michio, Saito Chikako, Hikichi Rie, Yamada Daiki, Minamidate Ai, Mochimaru Tomoaki, Asahara Shun-ichiro, Kido Yoshiaki, Oshima Shigeru, Nagaishi Takashi, Tsuchiya Kiichiro, Ohira Hiromasa, Okamoto Ryuichi, Watanabe Mamoru. D-セリンの経口投与によりマウスの大腸炎の発症および進行が抑制する(Oral administration of D-serine prevents the onset and progression of colitis in mice) Journal of Gastroenterology. 2021.08; 56 (8): 732-745. ( ichushi )

  5. Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochemistry and biophysics reports. 2021.03; 25 100906. ( PubMed, DOI )

  6. Tsuchiya Mao, Ito Go, Hama Minami, Nagata Sayaka, Kawamoto Ami, Suzuki Kohei, Shimizu Hiromichi, Anzai Sho, Takahashi Junichi, Kuno Reiko, Takeoka Sayaka, Hiraguri Yui, Sugihara Hady Yuki, Mizutani Tomohiro, Yui Shiro, Oshima Shigeru, Tsuchiya Kiichiro, Watanabe Mamoru, Okamoto Ryuichi. Functional analysis of isoflavones using patient-derived human colonic organoids BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.02; 542 40-47. ( PubMed, DOI )

  7. Aonuma Emi, Tamura Akiko, Matsuda Hiroki, Asakawa Takehito, Sakamaki Yuriko, Otsubo Kana, Nibe Yoichi, Onizawa Michio, Nemoto Yasuhiro, Nagaishi Takashi, Tsuchiya Kiichiro, Nakamura Tetsuya, Uo Motohiro, Watanabe Mamoru, Okamoto Ryuichi, Oshima Shigeru. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.02; 542 17-23. ( PubMed, DOI )

  8. Tsugawa Naoya, Yamada Daiki, Watabe Taro, Onizawa Michio, Wang Shuang, Nemoto Yasuhiro, Oshima Shigeru, Tsubata Takeshi, Adachi Takahiro, Kawano Yohei, Watanabe Mamoru, Blumberg Richard S., Okamoto Ryuichi, Nagaishi Takashi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.01; 535 99-105. ( PubMed, DOI )

  9. Morikawa Ryo, Nemoto Yasuhiro, Yonemoto Yuki, Tanaka Shohei, Takei Yuria, Oshima Shigeru, Nagaishi Takashi, Tsuchiya Kiichiro, Nozaki Kengo, Mizutani Tomohiro, Nakamura Tetsuya, Watanabe Mamoru, Okamoto Ryuichi. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2021; 11 (5): 1483-1503. ( PubMed, DOI )

  10. Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Lett.. 2020.05; 594 (10): 1586-1595. ( PubMed, DOI )

  11. Yuria Takei, Yasuhiro Nemoto, Ryo Morikawa, Shohei Tanaka, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 328-335. ( PubMed, DOI )

  12. Shohei Tanaka, Yasuhiro Nemoto, Yuria Takei, Ryo Morikawa, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Susanne Stutte, Mamoru Watanabe. High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage. Biochem. Biophys. Res. Commun.. 2020.02; 522 (4): 971-977. ( PubMed, DOI )

  13. Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kohei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Ohshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe. Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2018.11; 13 (4): 495-509. ( PubMed, DOI )

  14. Shigeru Oshima, Mamoru Watanabe. Genetic and environmental factors drive personalized medicine for Crohn's disease. J. Clin. Invest.. 2018.11; 128 (11): 4758-4760. ( PubMed, DOI )

  15. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed, DOI )

  16. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018.02; 14 (2): 347-358. ( PubMed, DOI )

  17. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. [Epub ahead of print] Stem Cell Reports. 2017.12; 10 (1): 27-42. ( PubMed, DOI )

  18. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed, DOI )

  19. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2017.03; 484 (3): 636-641. ( PubMed, DOI )

  20. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed, DOI )

  21. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun.. 2017.01; 482 (4): 1296-1303. ( PubMed, DOI )

  22. Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya. CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice ACTA HISTOCHEMICA ET CYTOCHEMICA. 2017; 50 (6): 159-168. ( PubMed, DOI )

  23. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed, DOI )

  24. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed, DOI )

  25. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed, DOI )

  26. Klionsky DJ, Oshima S, et al. （2387 人中1536 番目）. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016.01; 12 (1): 1-222. ( PubMed, DOI )

  27. Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, Juan A Oses-Prieto, Timothy Lu, Rita Tavares, Thomas Prodhomme, Bao Duong, Michael I Whang, Rommel Advincula, Alex Agelidis, Julio Barrera, Hao Wu, Alma Burlingame, Barbara A Malynn, Scott S Zamvil, Averil Ma. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis Nat Immunol. 2015.06; 16 (6): 618-627. ( PubMed, DOI )

  28. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed, DOI )

  29. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci.. 2015.05; ( PubMed, DOI )

  30. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem. Biophys. Res. Commun.. 2015.01; 456 (1): 298-304. ( PubMed, DOI )

  31. Masahiro Suzuki, Takashi Nagaishi, Motomi Yamazaki, Michio Onizawa, Taro Watabe, Yuriko Sakamaki, Shizuko Ichinose, Mamoru Totsuka, Shigeru Oshima, Ryuichi Okamoto, Motoyuki Shimonaka, Hideo Yagita, Tetsuya Nakamura, Mamoru Watanabe. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE. 2014.02; 9 (2): e88369. ( PubMed, DOI )

  32. Masahiro Takahara, Yasuhiro Nemoto, Shigeru Oshima, Yu Matsuzawa, Takanori Kanai, Ryuichi Okamoto, Kiichiro Tsuchiyaa, Tetsuy Nakamura, Kazuhide Yamamoto, Mamoru Watanabe.. IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 2013.11; 156 (1-2): 82-93. ( PubMed, DOI )

  33. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, and Mamoru Watanabe.. Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 2013.08; 62 (8): 1142-1152. ( PubMed, DOI )

  34. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013.07; 191 (2): 535-539. ( PubMed, DOI )

  35. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Satoshi Matsumoto and Mamoru Watanabe.. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J Immunol. 2013.06; 190 (12): 6616-6625. ( PubMed, DOI )

  36. Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS ONE. 2013.05; 8 (5): e62223. ( PubMed, DOI )

  37. Akihiro Araki, Shinji Suzuki, Kiichiro Tsuchiya, Shigeru Oshima, Eriko Okada, Mamoru Watanabe. Modified single-operator method for double-balloon endoscopy. Dig Endosc. 2012.11; 24 (6): 470-474. ( PubMed, DOI )

  38. Akihiro Araki, Kiichiro Tsuchiya, Shigeru Oshima, Eriko Okada, Shinji Suzuki, Junko Morio Akiyama, Toshimitsu Fujii, Ryuichi Okamoto, Mamoru Watanabe. Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report. J Med Case Rep. 2012.09; 6 328. ( PubMed, DOI )

  39. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, Defranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011.10; 12 (12): 1184-1193. ( PubMed, DOI )

  40. Akihiro Araki, Kiichiro Tsuchiya, Eriko Okada, Shinji Suzuki, Shigeru Oshima, Sanae Yoshioka, Atsushi Yoshioka, Takanori Kanai, Mamoru Watanabe. Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE. J. Gastroenterol. Hepatol.. 2009.05; 24 (5): 770-775. ( PubMed, DOI )

  41. Michio Onizawa, Takashi Nagaishi, Takanori Kanai, Ken-ichi Nagano, Shigeru Oshima, Yasuhiro Nemoto, Atsushi Yoshioka, Teruji Totsuka, Ryuichi Okamoto, Tetsuya Nakamura, Naoya Sakamoto, Kiichiro Tsuchiya, Kazuhiro Aoki, Keiichi Ohya, Hideo Yagita, Mamoru Watanabe. Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol.. 2009.04; 296 (4): G850-G859. ( PubMed, DOI )

  42. Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009.02; 457 (7231): 906-909. ( PubMed, DOI )

  43. A Araki, K Tsuchiya, E Okada, S Suzuki, S Oshima, R Okamoto, T Kanai, M Watanabe. Single-operator method for double-balloon endoscopy: a pilot study. Endoscopy. 2008.11; 40 (11): 936-938. ( PubMed, DOI )

  44. Atsushi Yoshioka, Ryuichi Okamoto, Shigeru Oshima, Junko Akiyama, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe. Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 2008.10; 44 (1): 57-64. ( PubMed, DOI )

  45. R Fujii, T Kanai, Y Nemoto, S Makita, S Oshima, R Okamoto, K Tsuchiya, T Totsuka, M Watanabe. FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am. J. Physiol. Gastrointest. Liver Physiol.. 2006.08; 291 (2): G267-G274. ( PubMed, DOI )

  46. Teruji Totsuka, Takanori Kanai, Shin Makita, Rei Fujii, Yasuhiro Nemoto, Shigeru Oshima, Ryuichi Okamoto, Akemi Koyanagi, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe. Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur. J. Immunol.. 2005.06; 35 (6): 1773-1785. ( PubMed, DOI )

  47. Tomoko Matsumoto, Ryuichi Okamoto, Tomoharu Yajima, Takehiko Mori, Shinichiro Okamoto, Yasuo Ikeda, Makio Mukai, Motomi Yamazaki, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Hideyuki Okano, Johji Inazawa, Toshifumi Hibi, Mamoru Watanabe. Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 2005.06; 128 (7): 1851-1867. ( PubMed )

  48. Shin Namiki, Tetsuya Nakamura, Shigeru Oshima, Motomi Yamazaki, Yuko Sekine, Kiichiro Tsuchiya, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett.. 2005.05; 579 (13): 2781-2787. ( PubMed, DOI )

  49. Eriko Okada, Motomi Yamazaki, Masanobu Tanabe, Tsutomu Takeuchi, Masanobu Nanno, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Toshifumi Hibi, Mamoru Watanabe. IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am. J. Physiol. Gastrointest. Liver Physiol.. 2005.04; 288 (4): G745-G754. ( PubMed, DOI )

  50. Shin Makita, Takanori Kanai, Shigeru Oshima, Koji Uraushihara, Teruji Totsuka, Taisuke Sawada, Tetsuya Nakamura, Kazutaka Koganei, Tsuneo Fukushima, Mamoru Watanabe. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J. Immunol.. 2004.09; 173 (5): 3119-3130. ( PubMed )

  51. Nobuhiko Kanazawa, Masayuki Kurosaki, Naoya Sakamoto, Nobuyuki Enomoto, Yasuhiro Itsui, Tsuyoshi Yamashiro, Yoko Tanabe, Shinya Maekawa, Mina Nakagawa, Cheng-Hsin Chen, Sei Kakinuma, Shigeru Oshima, Tetsuya Nakamura, Takanobu Kato, Takaji Wakita, Mamoru Watanabe. Regulation of hepatitis C virus replication by interferon regulatory factor 1. J. Virol.. 2004.09; 78 (18): 9713-9720. ( PubMed, DOI )

  52. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 2004.07; 24 (14): 6298-6310. ( PubMed, DOI )

  53. Motomi Yamazaki, Tomoharu Yajima, Masanobu Tanabe, Kazuto Fukui, Eriko Okada, Ryuichi Okamoto, Shigeru Oshima, Tetsuya Nakamura, Takanori Kanai, Masahiro Uehira, Tsutomu Takeuchi, Hiromichi Ishikawa, Toshifumi Hibi, Mamoru Watanabe. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J. Immunol.. 2003.08; 171 (3): 1556-1563. ( PubMed )

  54. Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura, Mamoru Watanabe. Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Curr Drug Targets Inflamm Allergy. 2003.06; 2 (2): 131-136. ( PubMed )

▼display all

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima. The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system.. 19th International congress of mucosal immunology 2019.07.17 the Brisbane Convention & Exhibition Centre(Brisbane, Australia)

  2. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. The 7th annual meeting of AOCC 2019.06.15 Taipei, Taiwan

  3. Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen（Denmark）

  4. Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Mamoru Watanabe. K33-linked polyubiquitin is recruited by SQSTM1/p62. Keystone Symposia: Autophagy(B2) 2019.02.19 New Mexico（USA）

  5. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna（Austria）

  6. Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M. Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. UEGW 2018 2018.10.22 Vienna（Austria）

  7. Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Long-lived secretory cells residing in the Mouse proximal colon serve as reserve stem cells Under DNA damage-induced mucosal injury. UEGW 2018 2018.10.22 Vienna（Austria）

  8. Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signalin. ISSCR2018 2018.06.20 Melbourne

  9. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.. Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.. DDW2018 2018.06.05 Washington D.C (USA）

  10. Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura ,Mamoru Watanabe. Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture. 13th Congress of ECCO 2018.02.16 Vienna（Austria）

  11. Otsubo K, Maeyashiki C, Aonuma E, Matsuda H, Nibe Y, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  12. Matsuda H, Nibe Y, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. K33-linked polyubiquitin is recruited by SQSTM1/p62.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  13. Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Mamoru Watanabe M, Oshima S. Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  14. Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.29 Tahoe(USA)

  15. S. Watanabe K. Tsuchiya T. Shirasaki S. Hibiya S. Ooshima T. Nakamura R. Nishimura R. Okamoto M. Watanabe. TP53 mutation acquires higher malignant potential in human colon cancer cells. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

  16. Nibe　Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy.. GI research Academy 2017 2017.06.09 経団連会館（東京都千代田区）

  17. Otsubo K, Oshima S, Maeyashiki C, Aonuma E, Matsuda H, Kobayashi M, Yoichi Nibe Y, Matsuzawa Y, Watanabe M. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. The 8th International Symposium on Autophagy 2017.05.29 Nara (Japan)

  18. Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p62. The 8th International Symposium on Autophagy 2017.05.29 Nara (Japan)

  19. Kobayashi m, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Watanabe M. The Ubiquitin Hybrid Gene UBA52 Regulates Cell Cycle and Ubiquitination of Ribosome in Colon Cancer. DDW 2017 2017.05.09 Chicago (USA)

  20. Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Lineage tracing reveals contribution of atoh1+ cell-derived stem cells in the homeostasis, repair, and carcinogenesis of the intestinal epithelium. DDW2017 2017.05.09 Chicago(USA)

  21. Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment. APDW2016 2016.11.03 Kobe convention center, KOBE（JAPAN）

  22. Shigeru Oshima. 【Digital Poster, Lower GI "Immunity and Inflammation 1"】Chairs. APDW2016 2016.11.03 Kobe convention center（Japan）

  23. Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.. UEGW2016 2016.10.18 Vienna（Austria）

  24. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  25. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  26. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer. DDW2016 2016.05.24 San Diego（USA）

  27. Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe. Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells. DDW2016 2016.05.23 San Diego（USA）

  28. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Tomohiro Mizutani, Shigeru Ochima, Mamotu Watanabe, Tetsuya Nakamura. Rethinol stimulates proliferation of epithelial stem cells of the proximal colon through a retinoic acid-indeoendent mechanism. DDW2016 2016.05.21 San Diego（USA）

  29. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid protein, regulates NF κB signaling. 第102回日本消化器病学会総会_The 5th International Forum 2016.04.21 京王プラザホテル（東京都新宿区）

  30. S Oshima,Y Matsuzawa,C Maeyashiki,M Kobayashi,Y Nibe,A Ma,M Watanabe. TNFAIP3 promotes survival of CD4 T cells by promoting autophagy. Cell Death and Immunity 2015.11.10 Berkeley

  31. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima , Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe. Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture . UEGW2015 2015.10.27 Barcelona

  32. Matsuzawa Y, Oshima S, Ma Averil , Watanabe M. A Crohn's disease susceptibility gene A20 promotes autophagy by restricting mTOR in CD4 T cells.. GI Research Academy 2015 2015.06.12 東京

  33. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells. DDW 2015 2015.05.19 Washinguton DC

  34. Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe. A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells. DDW 2015 2015.05.17 Washington, D.C.

  35. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Oshima S, Okamoto R, Nakamura T, Watanabe M. Long-term stimulation with cytokines acquires irreersible accumulation of NF-κB signaling in colonic epithelial cells. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  36. Matsuzawa Y, Oshima S, Takahara M, Nozaki K, Kobayashi M, Nibe Y, Maeyashiki C, Nemoto Y, Ma A, Watanabe M. A ubiquitin-modifying enzyme A20 controls the dynamics of autophagy. UEGW2014 2014.10.21 Vienna

▼display all

To the head of this page.▲