Personnel Information

写真a

OSHIMA Shigeru


Job title

Junior Associate Professor

Birth date

1972

Mail Address

The inquiry by e-mail is 《here

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1997, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2004, Completed

Campus Career 【 display / non-display

  • 2018.05
    -
    2019.10
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Gastroenterology and Hepatology, Junior Associate Professor
  • 2011.10
    -
    2013.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Advanced Therapeutics for GI Diseases, Assistant Professor
  • 2013.04
    -
    2015.07
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Gastroenterology and Hepatology, Assistant Professor
  • 2015.08
    -
    2018.04
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Gastroenterology and Hepatology, Assistant Professor
  • 2019.11
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Gastroenterology and Hepatology, Junior Associate Professor

External Career 【 display / non-display

  • , Senior Resident
  • , Assistant Professor
 

Published Papers & Misc 【 display / non-display

  • Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  • Minamidate A, Onizawa M, Saito C, Hikichi R, Mochimaru T, Murakami M, Sakuma C, Asakawa T, Hiraoka Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, Okamoto R, Watanabe M. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochemistry and biophysics reports. 2021.09; 27 101065. ( PubMed, DOI )

  • Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochemistry and biophysics reports. 2021.03; 25 100906. ( PubMed, DOI )

  • Tsuchiya Mao, Ito Go, Hama Minami, Nagata Sayaka, Kawamoto Ami, Suzuki Kohei, Shimizu Hiromichi, Anzai Sho, Takahashi Junichi, Kuno Reiko, Takeoka Sayaka, Hiraguri Yui, Sugihara Hady Yuki, Mizutani Tomohiro, Yui Shiro, Oshima Shigeru, Tsuchiya Kiichiro, Watanabe Mamoru, Okamoto Ryuichi. Functional analysis of isoflavones using patient-derived human colonic organoids BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.02; 542 40-47. ( PubMed, DOI )

  • Aonuma Emi, Tamura Akiko, Matsuda Hiroki, Asakawa Takehito, Sakamaki Yuriko, Otsubo Kana, Nibe Yoichi, Onizawa Michio, Nemoto Yasuhiro, Nagaishi Takashi, Tsuchiya Kiichiro, Nakamura Tetsuya, Uo Motohiro, Watanabe Mamoru, Okamoto Ryuichi, Oshima Shigeru. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.02; 542 17-23. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima. The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system.. 19th International congress of mucosal immunology 2019.07.17 the Brisbane Convention & Exhibition Centre(Brisbane, Australia)

  • Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. The 7th annual meeting of AOCC 2019.06.15 Taipei, Taiwan

  • Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen(Denmark)

  • Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Mamoru Watanabe. K33-linked polyubiquitin is recruited by SQSTM1/p62. Keystone Symposia: Autophagy(B2) 2019.02.19 New Mexico(USA)

  • Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna(Austria)

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