Personnel Information

写真a

HASEGAWA Hisanori


Job title

Junior Associate Professor

Birth date

1979

Mail Address

hasegawa.rheu@tmd.ac.jp

To the head of this page.▲

Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Education, 2000.03, Graduated

  • The University of Tokyo, Faculty of Pharmaceutical Science, 2002.03, Graduated

  • Tokyo Medical and Dental University, Faculty of Medicine, 2006.03, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2016.03, Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2008.04
    -
    2009.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Resident
  • 2010.04
    -
    2016.02
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Graduate Student
  • 2010.04
    -
    2016.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Graduate Student
  • 2011.07
    -
    2012.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Assistant Professor
  • 2013.04
    -
    2014.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Project Assistant Professor
  • 2017.04
    -
    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Assistant Professor
  • 2017.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2017.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Rheumatology， Assistant Professor
  • 2019.11
    -
    2021.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Assistant Professor
  • 2021.04
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Internal Medicine， Rheumatology， Junior Associate Professor
  • 2021.10
    -
    2022.12
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Rheumatology， Junior Associate Professor
  • 2023.01
    -
    2024.09
    Tokyo Medical and Dental University， Institute of Global Affairs， Institute of Global Affairs Administrative Division ， Junior Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， Offices under the Executive Board， Office of Global Affairs， Junior Associate Professor

▼display all

To the head of this page.▲

External Career 【 display / non-display 】

  • 2006.04
    -
    2007.03
    , Trainee Resident
  • 2007.04
    -
    2008.03
    , Trainee Resident
  • 2009.04
    -
    2010.03
    , Senior Resident
To the head of this page.▲

Research Areas 【 display / non-display 】

  • Connective tissue disease and allergy

To the head of this page.▲

Qualification Acquired 【 display / non-display 】

  • Doctor

  • Pharmacist

To the head of this page.▲
 

Research Theme 【 display / non-display 】

  • Direct suppression of autoaggressive CD8+ T cells with CD80/86 blockade in CD8+ T cell-mediated polymyositis models of mice.

To the head of this page.▲

Published Papers & Misc 【 display / non-display 】

  1. Takuji Itakura , Hirokazu Sasaki, Tadashi Hosoya, Natsuka Umezawa, Tetsuya Saito, Hideyuki Iwai, Hisanori Hasegawa, Hiroyuki Sato, Akihiro Hirakawa, Kohsuke Imai, Tomohiro Morio, Naoki Kimura, Shinsuke Yasuda. The role of TRECs/KRECs as immune indicators that reflect immunophenotypes and predict the risk of infection in systemic autoimmune diseases Immunological Medicine. 2025.09; ( DOI )

  2. Shuji Asai, Toshihisa Kojima, Hajime Ishikawa, Nobumasa Miyake, Masanari Kodera, Hisanori Hasegawa, Yasumori Sobue, Yasuhide Kanayama, Hiromi Shimada, Yuji Hirano, Toshihiko Hidaka, Takayoshi Fujibayashi, Takuya Matsumoto, Tomonori Kobayakawa, Hidekata Yasuoka, Takefumi Kato, Masahiro Hanabayashi, Yuko Kaneko, Masahiro Tada, Koichi Murata, Kenta Misaki, Masahiko Ando, Yachiyo Kuwatsuka, Mochihito Suzuki, Kenya Terabe, Shiro Imagama. Discontinuation vs. continuation of concomitant methotrexate in patients with rheumatoid arthritis on certolizumab pegol: results from a randomised, controlled trial Arthritis Research & Therapy. 2025.04; 27

  3. Daisuke Kawata, Hisanori Hasegawa, Naoki Kimura, Yasuhiro Tagawa, Hirokazu Sasaki, Shinsuke Yasuda. Immune Checkpoint Inhibitor-Induced Myositis, Myocarditis, Myasthenia Gravis, and Autonomic Neuropathy Successfully Treated With Rituximab Muscle & Nerve. 2025.03; 71 489-491.

  4. Hasegawa, H; Kashima, S; Otsu, M; Taniguchi, H; Yasuda, S. Development of a Human Cytotoxic Myoinjury Model with CD8+T Cells and Muscle Cells Differentiated from Human Induced Pluripotent Stem Cells ARTHRITIS & RHEUMATOLOGY. 2023.10; 75 592-593.

  5. Kamiya, M; Kimura, N; Umezawa, N; Hasegawa, H; Yasuda, S. Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy FRONTIERS IN IMMUNOLOGY. 2023.07; 14 1191815. ( PubMed, DOI )

  6. Umezawa, N; Mizoguchi, F; Maejima, Y; Kimura, N; Hasegawa, H; Hosoya, T; Fujimoto, M; Kohsaka, H; Naka, T; Yasuda, S. Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides FRONTIERS IN MEDICINE. 2023.05; 10 1153883. ( PubMed, DOI )

  7. Kondo, F; Sugihara, T; Umezawa, N; Hasegawa, H; Hosoya, T; Kimura, N; Mori, M; Yasuda, S. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease ARTHRITIS RESEARCH & THERAPY. 2022.04; 24 (1): 92. ( PubMed, DOI )

  8. Noda S, Honda S, Hirota Y, Ito T, Hasegawa H, Kimura N, Matsuo Y, Iwai H, Kohsaka H, Yasuda S. Azathioprine Monotherapy for the Cases of Immunoglobulin G4-Related Disease With Contraindications to Glucocorticoids. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2021.02; 27 (8S): S327-S330. ( PubMed, DOI )

  9. Tanaka Yoshiya, Kuwana Masataka, Fujii Takao, Kameda Hideto, Muro Yoshinao, Fujio Keishi, Itoh Yasuhiko, Yasuoka Hidekata, Fukaya Shusaku, Ashihara Konomi, Hirano Daisuke, Ohmura Koichiro, Tabuchi Yuya, Hasegawa Hisanori, Matsumiya Ryo, Shirai Yuichiro, Ogura Takehisa, Tsuchida Yumi, Ogawa-Momohara Mariko, Narazaki Hidehiko, Inoue Yoshino, Miyagawa Ippei, Nakano Kazuhisa, Hirata Shintaro, Mori Masaaki, the Japan research committee of the ministry of health,labor,and welfare for systemic autoimmune diseases. 2019 Diagnostic criteria for mixed connective tissue disease(MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases(和訳中) Modern Rheumatology. 2021.01; 31 (1): 29-33. ( ichushi )

  10. Tanaka Yoshiya, Kuwana Masataka, Fujii Takao, Kameda Hideto, Muro Yoshinao, Fujio Keishi, Itoh Yasuhiko, Yasuoka Hidekata, Fukaya Shusaku, Ashihara Konomi, Hirano Daisuke, Ohmura Koichiro, Tabuchi Yuya, Hasegawa Hisanori, Matsumiya Ryo, Shirai Yuichiro, Ogura Takehisa, Tsuchida Yumi, Ogawa-Momohara Mariko, Narazaki Hidehiko, Inoue Yoshino, Miyagawa Ippei, Nakano Kazuhisa, Hirata Shintaro, Mori Masaaki. 2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases MODERN RHEUMATOLOGY. 2021.01; 31 (1): 29-33. ( PubMed, DOI )

  11. Noda S, Hasegawa H, Tokura M, Mizoguchi F, Kohsaka H. A Case of Systemic Lupus Erythematosus Presenting With Thrombotic Microangiopathy-Induced Cardiomyopathy. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2020.02; 27 (8S): S847-S848. ( PubMed, DOI )

  12. Okumura Takashi, Horie Yumi, Lai Chen-Yi, Lin Huan-Ting, Shoda Hirofumi, Natsumoto Bunki, Fujio Keishi, Kumaki Eri, Okano Tsubasa, Ono Shintaro, Tanita Kay, Morio Tomohiro, Kanegane Hirokazu, Hasegawa Hisanori, Mizoguchi Fumitaka, Kawahata Kimito, Kohsaka Hitoshi, Moritake Hiroshi, Nunoi Hiroyuki, Waki Hironori, Tamaru Shin-ichi, Sasako Takayoshi, Yamauchi Toshimasa, Kadowaki Takashi, Tanaka Hiroyuki, Kitanaka Sachiko, Nishimura Ken, Ohtaka Manami, Nakanishi Mahito, Otsu Makoto. Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34(+) cells using the auto-erasable Sendai virus vector STEM CELL RESEARCH & THERAPY. 2019.06; 10 (1): 185. ( PubMed, DOI )

  13. Honda Suguru, Hirano Fumio, Mouri Mariko, Hasegawa Hisanori, Kohsaka Hitoshi. Aneurysm formation after stent grafting in vascular Behcet's disease ARTHRITIS & RHEUMATOLOGY. 2018.02; 70 (2): 322. ( PubMed, DOI )

  14. Hisanori Hasegawa, Kimito Kawahata, Fumitaka Mizoguchi, Naoko Okiyama, Nobuyuki Miyasaka, Hitoshi Kohsaka. Direct suppression of autoaggressive CD8+ T cells with CD80/86 blockade in CD8+ T cell-mediated polymyositis models of mice. Clin. Exp. Rheumatol.. 2017.07; 35 (4): 593-597. ( PubMed )

  15. Mizoguchi, F; Hasegawa, H; Kohsaka, H. Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts ARTHRITIS & RHEUMATOLOGY. 2016.10; 68

  16. Hosoya Tadashi, Mizoguchi Fumitaka, Hasegawa Hisanori, Miura Keiko, Koike Ryuji, Kubota Tetsuo, Miyasaka Nobuyuki, Kohsaka Hitoshi. TNFRSF1A遺伝子変異を認めず、トシリズマブ投与が奏効した、腫瘍壊死因子(TNF)受容体関連周期性症候群(TRAPS)の臨床的特徴を示す1症例(A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor(TNF) Receptor-associated Periodic Syndrome(TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab) Internal Medicine. 2015.08; 54 (16): 2069-2072. ( ichushi )

  17. Okiyama Naoko, Hasegawa Hisanori, Oida Takatoku, Hirata Shinya, Yokozeki Hiroo, Fujimoto Manabu, Miyasaka Nobuyuki, Kohsaka Hitoshi. Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD8 epitope peptide INTERNATIONAL IMMUNOLOGY. 2015.07; 27 (7): 327-332. ( PubMed, DOI )

  18. Okiyama Naoko, Hasegawa Hisanori, Oida Takatoku, Hirata Shinya, Yokozeki Hiroo, Fujimoto Manabu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 骨格筋Cタンパク質由来のCD8エピトープペプチドを提示する樹状細胞の移入により誘導可能な実験的筋炎(Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD8 epitope peptide) International Immunology. 2015.07; 27 (7): 327-332. ( ichushi )

  19. Hosoya Tadashi, Mizoguchi Fumitaka, Hasegawa Hisanori, Miura Keiko, Koike Ryuji, Kubota Tetsuo, Miyasaka Nobuyuki, Kohsaka Hitoshi. A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor (TNF) Receptor-associated Periodic Syndrome (TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab INTERNAL MEDICINE. 2015; 54 (16): 2069-2072. ( PubMed, DOI )

  20. Fukuda Shin, Nanki Toshihiro, Morio Tomohiro, Hasegawa Hisanori, Koike Ryuji, Miyasaka Nobuyuki. Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses MODERN RHEUMATOLOGY. 2014.05; 24 (3): 537-539. ( PubMed, DOI )

  21. Fukuda Shin, Nanki Toshihiro, Morio Tomohiro, Hasegawa Hisanori, Koike Ryuji, Miyasaka Nobuyuki. 多発性無菌性膿瘍患者における好中球浸潤を伴う再発性僧帽弁逆流(Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses) Modern Rheumatology. 2014.05; 24 (3): 537-539. ( ichushi )

  22. Hasegawa H., Mizoguchi F., Kohsaka H., Miyasaka N.. Systemic lupus erythematosus with cytophagic histiocytic panniculitis successfully treated with high-dose glucocorticoids and cyclosporine A LUPUS. 2013.03; 22 (3): 316-319. ( PubMed, DOI )

  23. Hasegawa Hisanori, Kohsaka Hitoshi, Takada Kazuki, Miyasaka Nobuyuki. Renal Involvement in Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody-positive Granulomatosis with Polyangiitis with Chronic Hypertrophic Pachymeningitis JOURNAL OF RHEUMATOLOGY. 2012.10; 39 (10): 2053-2055. ( PubMed, DOI )

  24. Hasegawa H, Fukushima T, Lee JA, Tsukamoto K, Moriya K, Ono Y, Imai K.. Determination of serum D-lactic and L-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization. Analytical and Bioanalytical Chemistry. 2003.11; 377 886-891.

  25. Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M.. Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Archives of General Psychiatry. 2003.06; 60 572-576.

▼display all

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. Tomoko Niwano, Taiki Yamaguchi, Daisuke Kawata, Yui Takeshita, Shunsuke Takagi, Seiya Oba, Hirokazu Sasaki, Akio Yamamoto, Natsuka Umezawa, Tetsuya Saito, Hisanori Hasegawa, Naoki Kimura, Hideyuki Iwai, Keita Mochizuki, Toshikazu Fukami, Keisuke Izumi, Kazumichi Minato, Ryuji Koike, Shinsuke Yasuda, Tadashi Hosoya. Predicting Disease State in Patients with Systemic Lupus Erythematosus using Digital Biomarkers from Wearable Devices. 27 th Asia Pacific League of Associations for Rheumatology 2025.09.03 Fukuoka

  2. Tomoko Niwano, Taiki Yamaguchi, Daisuke Kawata, Yui Takeshita, Shunsuke Takagi, Seiya Oba, Hirokazu Sasaki, Akio Yamamoto, Natsuka Umezawa, Tetsuya Saito, Hisanori Hasegawa, Naoki Kimura, Hideyuki Iwai, Keita Mochizuki, Toshikazu Fukami, Keisuke Izumi, Kazumichi Minato, Ryuji Koike, Shinsuke Yasuda, Tadashi Hosoya. Prediction of Disease Activity Status in Patients with Systemic Lupus Erythematosus by utilizing Wrist-Worn Wearable Devices. The European Alliance of Associations for Rheumatology (EULAR) 2025 Congress 2025.06.11 Barcelona

  3. Shuji Asai, Toshihisa Kojima, Hajime Ishikawa, Nobumasa Miyake, Masanari Kodera, Hisanori Hasegawa, Yasumori Sobue, Yasuhide Kanayama, Hiromi Shimada, Yuji Hirano, Toshihiko Hidaka, Takayoshi Fujibayashi, Takuya Matsumoto, Tomonori Kobayakawa, Hidekata Yasuoka, Takefumi Kato, Masahiro Hanabayashi, Yuko Kaneko, Masahiro Tada, Koichi Murata, Kenta Misaki, Masahiko Ando, Yachiyo Kuwatsuka, Mochihito Suzuki, Kenya Terabe, Shiro Imagama. Discontinuation vs. continuation of concomitant methotrexate in patients with rheumatoid arthritis on certolizumab pegol: Results from a randomized, controlled trial. EULAR 2025 Congress 2025.06.11

  4. Yamaguchi Taiki, Hosoya Tadashi, Sasaki Hirokazu, Yamamoto Akio, Umezawa Natsuka, Hasegawa Hisanori, Kimura Naoki, Saito Tetsuya, Iwai Hideyuki, Koike Ryuji, Kochi Yuta, Yasuda Shinsuke. 関節リウマチの臨床研究3　難治性関節リウマチ患者のpolygenic score解析(Clinical study in RA 3　Polygenic score analysis of refractory rheumatoid arthritis patients). 日本リウマチ学会総会・学術集会プログラム・抄録集 2025.03.01

  5. Mizoguchi Fumitaka, Hasegawa Hisanori, Kohsaka Hitoshi. Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts. 2016 American College of Rheumatology 2016.11.16

  6. Okiyama Naoko, Hasegawa HIsanori, Oida Takatoku, Hirata Shinya, Yokozeki Hiroo, Fujimoto Manabu, Kohsaka Hitoshi. 臓器特異的自己免疫疾患(2) 骨格筋C蛋白由来CD8Tエピトープペプチドを提示する樹状細胞の移入により誘発可能は実験的筋炎. 第44回(2015年)日本免疫学会学術集会 2015.11.19

  7. Okiyama Naoko, Hasegawa Hisanori, Oida Takatoku, Hirata Shinya, Yokozeki Hiroo, Fujimoto Manabu, Kohsaka Hitoshi. 臓器特異的自己免疫疾患(2)　骨格筋C蛋白由来CD8エピトープペプチドを提示する樹状細胞の移入により誘発可能な実験的筋炎(Organ-specific autoimmune diseases(2)　Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD8 epitope peptide). 日本免疫学会総会・学術集会記録 2015.10.01

  8. Naoko Okiyama, Hisanori Hasegawa, Takamori Oida, Sinya Hirata,Hiroo Yokozeki, Manabu Fujimoto, Nobuyuki Miyasaka, Hitoshi Kohsaka.. Experimental Myositis Inducible with Transfer of Dendritic Cells Presenting a Skeletal Muscle C protein-derived CD8 Epitope Peptide.. 1st International Conference on Myositis 2015.05.08 Stockholm, Sweden

  9. Hisanori Hasegawa, Fumitaka Mizoguchi, Naoko Okiyama, Miyuki Azuma, Nobuyuki Miyaksaka, Hitoshi Kohsaka. . 6. CD28-CD80/86 blockade by CTLA-4Ig suppresses murine models of polymyositis driven by cytotoxic CD8 T cells. . The 5th East Asian Group of Rheumatology 2013.06.01

  10. Hasegawa Hisanori, Mizoguchi Fumitaka, Okiyama Naoko, Azuma Miyuki, Miyasaka Nobuyuki, Kohsaka Hitoshi. 多発性筋炎・皮膚筋炎　CD28-CD80/86の共刺激を阻害することによるCD8陽性T細胞に依存的な多発性筋炎モデルの治療(Treatment of polymyositis models dependent on CD8 T cells by inhibiting CD28-CD80/86 costimulation). 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 2013.03.01

  11. Hasegawa Hisanori, Mizoguchi Fumitaka, Azuma Miyuki, Miyasaka Nobuyuki, Kohsaka Hitoshi. 全身性自己免疫疾患(1)　CD8 T細胞依存性の多発性筋炎モデルに対するCD28-CD80/86共刺激の阻害による治療(Treatment of polymyositis model dependent on CD8 T cells by inhibition of CD28-CD80/86 costimulation). 日本免疫学会総会・学術集会記録 2012.11.01

▼display all

To the head of this page.▲

Awards & Honors 【 display / non-display 】

  • Young investigator award，East Asian Group of Rheumatology，2013.05

To the head of this page.▲
 

Campus class subject 【 display / non-display 】

  • HSLP Leadership，2025 - Now

  • グローバルヘルスリーダー養成コース/公衆衛生のための医学・生物学: Host response to infection: the immune response and vaccination，2024 - Now

  • HSLP Design Thinking，2024 - Now

  • HSLP Moral and Political Philosoph，2024 - Now

  • HSLP Negotiation，2024

  • Find Your Role Model Session，2023 - Now

  • Global Communication Workshop，2023 - Now

▼display all

To the head of this page.▲

Performance of duties 【 display / non-display 】

  • ，2016.04 - Now

To the head of this page.▲