経歴(学内) 【 表示 / 非表示 】
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2011年06月-2013年03月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 特任助教
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2013年04月-2015年06月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 助教
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2015年07月-2016年03月東京医科歯科大学 (旧組織)医学部附属病院 診療科 感覚・皮膚・運動機能診療部門 眼科 助教
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2017年04月-2018年03月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 助教
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2018年04月-2023年03月東京医科歯科大学 大学院医歯学総合研究科 寄附講座 先端視覚画像医学講座 講師
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2023年04月-2023年06月東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 特任講師
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2023年07月-2024年03月東京医科歯科大学 病院 医系診療部門 感覚・皮膚・運動機能診療領域 眼科 講師
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2024年04月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 講師
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2024年04月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 認知行動医学講座 眼科学 講師
競争的資金等の研究課題 【 表示 / 非表示 】
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網膜色素上皮細胞による眼内ミエロイド細胞制御機構の解析と新規治療分子の検討
文部科学省/日本学術振興会 : 2014年 - 2016年
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網膜色素上皮細胞による眼内ミエロイド細胞制御機構の解析と新規治療分子の検討
文部科学省/日本学術振興会 : 2014年 - 2015年
論文・総説 【 表示 / 非表示 】
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Hiroshi Keino, Shintaro Horie, Sunao Sugita. Immune Privilege and Eye-Derived T-Regulatory Cells. J Immunol Res. 2018.05; 2018 1679197. ( PubMed, DOI )
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Yoshiyuki Kawashima, Yoshihiro Noguchi, Hiroshi Takase, Masatoki Takahashi, Shintaro Horie. Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. Am J Otolaryngol. 2015.08; 36 (4): 606-610. ( PubMed, DOI )
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Shintaro Horie, Scott J Robbie, Jian Liu, Wei-Kang Wu, Robin R Ali, James W Bainbridge, Lindsay B Nicholson, Manabu Mochizuki, Andrew D Dick, David A Copland. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Sci Rep. 2013.10; 3 3072. ( PubMed, DOI )
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Sunao Sugita, Yuko Kawazoe, Ayano Imai, Tatsushi Kawaguchi, Shintaro Horie, Hiroshi Keino, Masayo Takahashi, Manabu Mochizuki. Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease. J. Immunol.. 2013.06; 190 (11): 5799-5808. ( PubMed, DOI )
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Jian Liu, David A Copland, Shintaro Horie, Wei-Kang Wu, Mei Chen, Yunhe Xu, B Paul Morgan, Matthias Mack, Heping Xu, Lindsay B Nicholson, Andrew D Dick. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE. 2013; 8 (8): e72935. ( PubMed, DOI )
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Sunao Sugita, Yuko Kawazoe, Yukiko Yamada, Ayano Imai, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells. Br J Ophthalmol. 2012.02; 96 (2): 293-299. ( PubMed, DOI )
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Yuko Kawazoe, Sunao Sugita, Hiroshi Keino, Yukiko Yamada, Ayano Imai, Shintaro Horie, Manabu Mochizuki. Retinoic acid from retinal pigment epithelium induces T regulatory cells. Exp. Eye Res.. 2012.01; 94 (1): 32-40. ( PubMed, DOI )
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Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease. Arthritis Res. Ther.. 2012; 14 (3): R99. ( PubMed, DOI )
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Ayano Imai, Sunao Sugita, Yuko Kawazoe, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Kazuichi Maruyama, Manabu Mochizuki. Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells. Invest. Ophthalmol. Vis. Sci.. 2012; 53 (11): 7299-7309. ( PubMed, DOI )
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Sunao Sugita, Shintaro Horie, Yukiko Yamada, Yuko Kawazoe, Hiroshi Takase, Manabu Mochizuki. Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells. Jpn. J. Ophthalmol.. 2011.09; 55 (5): 565-575. ( PubMed, DOI )
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Sunao Sugita, Yukiko Yamada, Shintaro Horie, Orie Nakamura, Kazumi Ishidoh, Yoshimi Yamamoto, Satoru Yamagami, Manabu Mochizuki. Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells. Invest. Ophthalmol. Vis. Sci.. 2011.04; 52 (5): 2598-2605. ( PubMed, DOI )
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Sunao Sugita, Norio Shimizu, Ken Watanabe, Miki Katayama, Shintaro Horie, Manabu Ogawa, Hiroshi Takase, Yoshiharu Sugamoto, Manabu Mochizuki. Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. Br J Ophthalmol. 2011.03; 95 (3): 345-349. ( PubMed, DOI )
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Sunao Sugita, Shintaro Horie, Yukiko Yamada, Manabu Mochizuki. Inhibition of B-cell activation by retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci.. 2010.11; 51 (11): 5783-5788. ( PubMed, DOI )
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Masaru Miyanaga, Tatsushi Kawaguchi, Kazunori Miyata, Shintaro Horie, Manabu Mochizuki, Carl P Herbort. Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. Jpn. J. Ophthalmol.. 2010.09; 54 (5): 377-382. ( PubMed, DOI )
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Shintaro Horie, Sunao Sugita, Yuri Futagami, Yukiko Yamada, Manabu Mochizuki. Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells. Clin. Immunol.. 2010.07; 136 (1): 83-95. ( PubMed, DOI )
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Sunao Sugita, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Yoshihiko Usui, Masaru Takeuchi, Manabu Mochizuki. Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2529-2536. ( PubMed, DOI )
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Yukiko Yamada, Sunao Sugita, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2548-2557. ( PubMed, DOI )
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Tatsushi Kawaguchi, Shintaro Horie, Nadia Bouchenaki, Kyoko Ohno-Matsui, Manabu Mochizuki, Carl P Herbort. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2010.02; 30 (1): 41-50. ( PubMed, DOI )
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Sunao Sugita, Shintaro Horie, Orie Nakamura, Kazuichi Maruyama, Hiroshi Takase, Yoshihiko Usui, Masaru Takeuchi, Kazumi Ishidoh, Masato Koike, Yasuo Uchiyama, Christoph Peters, Yoshimi Yamamoto, Manabu Mochizuki. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J. Immunol.. 2009.10; 183 (8): 5013-5022. ( PubMed, DOI )
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Shintaro Horie, Sunao Sugita, Yuri Futagami, Tastushi Kawaguchi, Koju Kamoi, Shiroaki Shirato, Manabu Mochizuki. Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction. Exp. Eye Res.. 2009.06; 88 (6): 1033-1042. ( PubMed, DOI )
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Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Hiroyuki Aburatani, Taku Okazaki, Tasuku Honjo, Masaru Takeuchi, Manabu Mochizuki. T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest. Ophthalmol. Vis. Sci.. 2009.06; 50 (6): 2862-2870. ( PubMed, DOI )
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Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Yukiko Yamada, Juan Ma, Takeshi Kezuka, Hirofumi Hamada, Tomohiko Usui, Manabu Mochizuki, Satoru Yamagami. Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism. Invest. Ophthalmol. Vis. Sci.. 2009.01; 50 (1): 263-272. ( PubMed, DOI )
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Sunao Sugita, Shintaro Horie, Orie Nakamura, Yuri Futagami, Hiroshi Takase, Hiroshi Keino, Hiroyuki Aburatani, Nobuhiko Katunuma, Kazumi Ishidoh, Yoshimi Yamamoto, Manabu Mochizuki. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J. Immunol.. 2008.12; 181 (11): 7525-7536. ( PubMed )
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Sunao Sugita, Yuri Futagami, Shintaro Horie, Manabu Mochizuki. Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions. Exp. Eye Res.. 2007.11; 85 (5): 626-636. ( PubMed, DOI )
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Horie Shintaro, Kukimoto Nobuyuki, Kamoi Koju, Igarashi-Yokoi Tae, Yoshida Takeshi, Ohno-Matsui Kyoko. Blue Widefield Images of Scanning Laser Ophthalmoscope Can Detect Retinal Ischemic Areas in Eyes With Diabetic Retinopathy ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY. 2021; 10 (5): 478-485. ( PubMed, DOI )
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Horiguchi Noe, Kamoi Koju, Horie Shintaro, Iwasaki Yuko, Kurozumi-Karube Hisako, Takase Hiroshi, Ohno-Matsui Kyoko. A 10-year follow-up of infliximab monotherapy for refractory uveitis in Behcet's syndrome SCIENTIFIC REPORTS. 2020.12; 10 (1): 22227. ( PubMed, DOI )
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Tanaka Noriko, Shinohara Kosei, Yokoi Tae, Uramoto Kengo, Takahashi Hiroyuki, Onishi Yuka, Horie Shintaro, Yoshida Takeshi, Ohno-Matsui Kyoko. Detection of Early Changes of Posterior Staphylomas in Children and Young Adults by Ultra wide-field OCT INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2019.07; 60 (9):
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Tanaka Noriko, Shinohara Kosei, Yokoi Tae, Uramoto Kengo, Takahashi Hiroyuki, Onishi Yuka, Horie Shintaro, Yoshida Takeshi, Ohno-Matsui Kyoko. Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography PLOS ONE. 2019.06; 14 (6): e0218107. ( PubMed, DOI )
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Vutipongsatorn Kritchai, Nagaoka Natsuko, Yokoi Tae, Yoshida Takeshi, Kamoi Koju, Horie Shintaro, Uramoto Kengo, Hirata Akira, Occelli Laurence M., Petersen-Jones Simon M., Montiani-Ferreira Fabiano, Cases Olivier, Kozyraki Renata, Jonas Jost B., Ohno-Matsui Kyoko. CORRELATIONS BETWEEN EXPERIMENTAL MYOPIA MODELS AND HUMAN PATHOLOGIC MYOPIA RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES. 2019.04; 39 (4): 621-635. ( PubMed, DOI )
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住友 沙織, 堀江 真太郎, 大野 京子. 第71回日本臨床眼科学会講演集[2] 嚢胞様黄斑浮腫における硬性白斑をen face OCTにより経時的に観察した1例 臨床眼科. 2018.04; 72 (4): 579-585. ( 医中誌 )
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Sunao Sugita, Youichi Iwanaga, Tatsushi Kawaguchi, Yuri Futagami, Shintaro Horie, Tomoka Usui, Sayaka Yamamoto, Yoshiharu Sugamoto, Manabu Mochizuki, Norio Shimizu, Ken Watanabe, Miki Mizukami, Tomohiro Morio. [Detection of herpesvirus genome by multiplex polymerase chain reaction (PCR) and real-time PCR in ocular fluids of patients with acute retinal necrosis]. Nippon Ganka Gakkai Zasshi. 2008.01; 112 (1): 30-38. ( PubMed )
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Sunao Sugita, Yuri Futagami, Shintaro Horie, Hiroyuki Aburatani, Manabu Mochizuki. [Murine ciliary body pigment epithelial cells inhibit activation of T cells]. Nippon Ganka Gakkai Zasshi. 2007.08; 111 (8): 598-605. ( PubMed )
講演・口頭発表等 【 表示 / 非表示 】
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高橋 洋如, 中尾 紀子, 堀江 真太郎, 篠原 宏成, 大野 京子. 超広角OCTによる糖尿病網膜症の網膜硝子体癒着の観察. 眼科臨床紀要 2021.10.01
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堀口 乃恵, 鴨居 功樹, 堀江 真太郎, 大野 京子. Behcet病による難治性網膜ぶどう膜炎におけるInfliximab治療の長期成績. 日本眼科学会雑誌 2019.03.01
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高瀬 博, 堀口 乃恵, 岩崎 優子, 宮永 将, 宮内 真理, 輕部 央子, 堀江 真太郎, 田中 美由紀, 鴨居 功樹, 森 雅亮, 大野 京子. 非感染性ぶどう膜炎に対するアダリムマブの有効性の検討. 日本眼科学会雑誌 2019.03.01
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堀江 真太郎, 諸星 計. 糖尿病黄斑浮腫におけるEn-face OCTと毛細血管網の特徴. 日本糖尿病眼学会誌 2018.09.01
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輕部央子, 鴨居功樹,堀江真太郎,高瀬博,大野京子,望月學 . アダリムマブ導入でベーチェット病のぶどう膜炎を抑制できた一例. 第48回日本眼炎症学会 2014.07.05
その他業績 【 表示 / 非表示 】
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「青波長走査型レーザー広角眼底写真は糖尿病網膜症の網膜虚血を示す」―糖尿病網膜症の網膜虚血を非侵襲的かつ簡易に検出することができる―,2021年09月
Asia-Pacific Journal of Ophthalmology