Personnel Information

写真a

HORIE Shintaro


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • Tohoku University, Faculty of Medicine, 2000, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2009, Completed

Degree 【 display / non-display

  • PhD, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2011.06
    -
    2013.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Ophthalmology and Visual Science, Project Assistant Professor
  • 2013.04
    -
    2015.06
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Ophthalmology and Visual Science, Assistant Professor
  • 2015.07
    -
    2016.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Sensory, Orthopedic, and Dematologic Medicine, Ophthalmology, Assistant Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Ophthalmology and Visual Science, Assistant Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Advanced Ophthalmic Imaging, Junior Associate Professor

Research Areas 【 display / non-display

  • Ophthalmology

 

Published Papers & Misc 【 display / non-display

  1. Hiroshi Keino, Shintaro Horie, Sunao Sugita. Immune Privilege and Eye-Derived T-Regulatory Cells. J Immunol Res. 2018.05; 2018 1679197. ( PubMed, DOI )

  2. Yoshiyuki Kawashima, Yoshihiro Noguchi, Hiroshi Takase, Masatoki Takahashi, Shintaro Horie. Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. Am J Otolaryngol. 2015.08; 36 (4): 606-610. ( PubMed, DOI )

  3. Shintaro Horie, Scott J Robbie, Jian Liu, Wei-Kang Wu, Robin R Ali, James W Bainbridge, Lindsay B Nicholson, Manabu Mochizuki, Andrew D Dick, David A Copland. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Sci Rep. 2013.10; 3 3072. ( PubMed, DOI )

  4. Sunao Sugita, Yuko Kawazoe, Ayano Imai, Tatsushi Kawaguchi, Shintaro Horie, Hiroshi Keino, Masayo Takahashi, Manabu Mochizuki. Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease. J. Immunol.. 2013.06; 190 (11): 5799-5808. ( PubMed, DOI )

  5. Jian Liu, David A Copland, Shintaro Horie, Wei-Kang Wu, Mei Chen, Yunhe Xu, B Paul Morgan, Matthias Mack, Heping Xu, Lindsay B Nicholson, Andrew D Dick. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE. 2013; 8 (8): e72935. ( PubMed, DOI )

  6. Sunao Sugita, Yuko Kawazoe, Yukiko Yamada, Ayano Imai, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells. Br J Ophthalmol. 2012.02; 96 (2): 293-299. ( PubMed, DOI )

  7. Yuko Kawazoe, Sunao Sugita, Hiroshi Keino, Yukiko Yamada, Ayano Imai, Shintaro Horie, Manabu Mochizuki. Retinoic acid from retinal pigment epithelium induces T regulatory cells. Exp. Eye Res.. 2012.01; 94 (1): 32-40. ( PubMed, DOI )

  8. Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease. Arthritis Res. Ther.. 2012; 14 (3): R99. ( PubMed, DOI )

  9. Ayano Imai, Sunao Sugita, Yuko Kawazoe, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Kazuichi Maruyama, Manabu Mochizuki. Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells. Invest. Ophthalmol. Vis. Sci.. 2012; 53 (11): 7299-7309. ( PubMed, DOI )

  10. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Yuko Kawazoe, Hiroshi Takase, Manabu Mochizuki. Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells. Jpn. J. Ophthalmol.. 2011.09; 55 (5): 565-575. ( PubMed, DOI )

  11. Sunao Sugita, Yukiko Yamada, Shintaro Horie, Orie Nakamura, Kazumi Ishidoh, Yoshimi Yamamoto, Satoru Yamagami, Manabu Mochizuki. Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells. Invest. Ophthalmol. Vis. Sci.. 2011.04; 52 (5): 2598-2605. ( PubMed, DOI )

  12. Sunao Sugita, Norio Shimizu, Ken Watanabe, Miki Katayama, Shintaro Horie, Manabu Ogawa, Hiroshi Takase, Yoshiharu Sugamoto, Manabu Mochizuki. Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. Br J Ophthalmol. 2011.03; 95 (3): 345-349. ( PubMed, DOI )

  13. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Manabu Mochizuki. Inhibition of B-cell activation by retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci.. 2010.11; 51 (11): 5783-5788. ( PubMed, DOI )

  14. Masaru Miyanaga, Tatsushi Kawaguchi, Kazunori Miyata, Shintaro Horie, Manabu Mochizuki, Carl P Herbort. Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. Jpn. J. Ophthalmol.. 2010.09; 54 (5): 377-382. ( PubMed, DOI )

  15. Shintaro Horie, Sunao Sugita, Yuri Futagami, Yukiko Yamada, Manabu Mochizuki. Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells. Clin. Immunol.. 2010.07; 136 (1): 83-95. ( PubMed, DOI )

  16. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Yoshihiko Usui, Masaru Takeuchi, Manabu Mochizuki. Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2529-2536. ( PubMed, DOI )

  17. Yukiko Yamada, Sunao Sugita, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2548-2557. ( PubMed, DOI )

  18. Tatsushi Kawaguchi, Shintaro Horie, Nadia Bouchenaki, Kyoko Ohno-Matsui, Manabu Mochizuki, Carl P Herbort. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2010.02; 30 (1): 41-50. ( PubMed, DOI )

  19. Sunao Sugita, Shintaro Horie, Orie Nakamura, Kazuichi Maruyama, Hiroshi Takase, Yoshihiko Usui, Masaru Takeuchi, Kazumi Ishidoh, Masato Koike, Yasuo Uchiyama, Christoph Peters, Yoshimi Yamamoto, Manabu Mochizuki. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J. Immunol.. 2009.10; 183 (8): 5013-5022. ( PubMed, DOI )

  20. Shintaro Horie, Sunao Sugita, Yuri Futagami, Tastushi Kawaguchi, Koju Kamoi, Shiroaki Shirato, Manabu Mochizuki. Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction. Exp. Eye Res.. 2009.06; 88 (6): 1033-1042. ( PubMed, DOI )

  21. Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Hiroyuki Aburatani, Taku Okazaki, Tasuku Honjo, Masaru Takeuchi, Manabu Mochizuki. T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest. Ophthalmol. Vis. Sci.. 2009.06; 50 (6): 2862-2870. ( PubMed, DOI )

  22. Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Yukiko Yamada, Juan Ma, Takeshi Kezuka, Hirofumi Hamada, Tomohiko Usui, Manabu Mochizuki, Satoru Yamagami. Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism. Invest. Ophthalmol. Vis. Sci.. 2009.01; 50 (1): 263-272. ( PubMed, DOI )

  23. Sunao Sugita, Shintaro Horie, Orie Nakamura, Yuri Futagami, Hiroshi Takase, Hiroshi Keino, Hiroyuki Aburatani, Nobuhiko Katunuma, Kazumi Ishidoh, Yoshimi Yamamoto, Manabu Mochizuki. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J. Immunol.. 2008.12; 181 (11): 7525-7536. ( PubMed )

  24. Sunao Sugita, Yuri Futagami, Shintaro Horie, Manabu Mochizuki. Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions. Exp. Eye Res.. 2007.11; 85 (5): 626-636. ( PubMed, DOI )

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