Personnel Information

写真a

HORIE Shintaro


Job title

Junior Associate Professor
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Graduating School 【 display / non-display 】

  • Tohoku University, Faculty of Medicine, 2000, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2009, Completed

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Degree 【 display / non-display 】

  • PhD, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2011.06
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    2013.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Project Assistant Professor
  • 2013.04
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    2015.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Assistant Professor
  • 2015.07
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    2016.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Sensory, Orthopedic, and Dematologic Medicine， Ophthalmology， Assistant Professor
  • 2017.04
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    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Assistant Professor
  • 2018.04
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    2023.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Endowed Departments， Department of Advanced Ophthalmic Imaging， Junior Associate Professor
  • 2023.04
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    2023.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Project Junior Associate Professor
  • 2023.07
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    2024.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Sensory, Orthopaedic, and Dermatologic Medicine， Ophthalmology， Junior Associate Professor
  • 2024.04
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    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Junior Associate Professor
  • 2024.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Ophthalmology and Visual Science， Junior Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Cognitive and Behavioral Medicine， Department of Ophthalmology and Visual Science， Junior Associate Professor

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Research Areas 【 display / non-display 】

  • Ophthalmology

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Published Papers & Misc 【 display / non-display 】

  1. Yasuda, S; Yoshida, T; Suzuki, Y; Sugahara, Y; Lee, JFK; Kamoi, K; Horie, S; Takase, H; Ohno-Matsui, K. Retromode Infrared Scanning Laser Ophthalmoscopy in Vogt-Koyanagi-Harada Disease GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2024.11; ( PubMed, DOI )

  2. Horie, S; Suzuki, Y; Yoshida, T; Ohno-Matsui, K. Blue Wavelength of Scanning Laser Ophthalmoscope Potentially Detects Arteriosclerotic Lesions in Diabetic Retinopathy DIAGNOSTICS. 2024.07; 14 (13): ( PubMed, DOI )

  3. Yoshida, T; Nomura, T; Yoshimoto, S; Ohno, M; Ito, T; Horie, S; Ohno-Matsui, K. Outcomes of standalone ab interno trabeculotomy in the treatment of open-angle glaucoma in eyes with high myopia BMC OPHTHALMOLOGY. 2023.06; 23 (1): 261. ( PubMed, DOI )

  4. Ide H, Akehi Y, Fukuhara S, Ohira S, Ogawa S, Kataoka T, Kumagai H, Kobayashi K, Komiya A, Shigehara K, Syuto T, Soh J, Tanabe M, Taniguchi H, Chiba K, Matsushita K, Mitsui Y, Yoneyama T, Shirakawa T, Fujii Y, Kumano H, Ueshiba H, Amano T, Sasaki H, Maeda S, Mizokami A, Suzuki K, Horie S. Summary of the clinical practice manual for late-onset hypogonadism. International journal of urology : official journal of the Japanese Urological Association. 2023.05; 30 (5): 422-430. ( PubMed, DOI )

  5. Horie, S; Giulia, C; Esmaeilkhanian, H; Sadda, SR; Cheung, CMG; Ham, Y; Chang, AD; Takahashi, T; Ohno-Matsui, K. Microperimetry in Retinal Diseases ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY. 2023.03; 12 (2): 211-227. ( PubMed, DOI )

  6. Horie, S; Ohno-Matsui, K. Progress of Imaging in Diabetic Retinopathy-From the Past to the Present DIAGNOSTICS. 2022.07; 12 (7): ( PubMed, DOI )

  7. Horie S, Takase H, Yoshida T, Ohno-Matsui K. Sympathetic ophthalmia in eye with pathologic myopia. American journal of ophthalmology case reports. 2022.03; 25 101295. ( PubMed, DOI )

  8. Hiroshi Keino, Shintaro Horie, Sunao Sugita. Immune Privilege and Eye-Derived T-Regulatory Cells. J Immunol Res. 2018.05; 2018 1679197. ( PubMed, DOI )

  9. Yoshiyuki Kawashima, Yoshihiro Noguchi, Hiroshi Takase, Masatoki Takahashi, Shintaro Horie. Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. Am J Otolaryngol. 2015.08; 36 (4): 606-610. ( PubMed, DOI )

  10. Shintaro Horie, Scott J Robbie, Jian Liu, Wei-Kang Wu, Robin R Ali, James W Bainbridge, Lindsay B Nicholson, Manabu Mochizuki, Andrew D Dick, David A Copland. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Sci Rep. 2013.10; 3 3072. ( PubMed, DOI )

  11. Sunao Sugita, Yuko Kawazoe, Ayano Imai, Tatsushi Kawaguchi, Shintaro Horie, Hiroshi Keino, Masayo Takahashi, Manabu Mochizuki. Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease. J. Immunol.. 2013.06; 190 (11): 5799-5808. ( PubMed, DOI )

  12. Jian Liu, David A Copland, Shintaro Horie, Wei-Kang Wu, Mei Chen, Yunhe Xu, B Paul Morgan, Matthias Mack, Heping Xu, Lindsay B Nicholson, Andrew D Dick. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE. 2013; 8 (8): e72935. ( PubMed, DOI )

  13. Sunao Sugita, Yuko Kawazoe, Yukiko Yamada, Ayano Imai, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells. Br J Ophthalmol. 2012.02; 96 (2): 293-299. ( PubMed, DOI )

  14. Yuko Kawazoe, Sunao Sugita, Hiroshi Keino, Yukiko Yamada, Ayano Imai, Shintaro Horie, Manabu Mochizuki. Retinoic acid from retinal pigment epithelium induces T regulatory cells. Exp. Eye Res.. 2012.01; 94 (1): 32-40. ( PubMed, DOI )

  15. Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease. Arthritis Res. Ther.. 2012; 14 (3): R99. ( PubMed, DOI )

  16. Ayano Imai, Sunao Sugita, Yuko Kawazoe, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Kazuichi Maruyama, Manabu Mochizuki. Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells. Invest. Ophthalmol. Vis. Sci.. 2012; 53 (11): 7299-7309. ( PubMed, DOI )

  17. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Yuko Kawazoe, Hiroshi Takase, Manabu Mochizuki. Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells. Jpn. J. Ophthalmol.. 2011.09; 55 (5): 565-575. ( PubMed, DOI )

  18. Sunao Sugita, Yukiko Yamada, Shintaro Horie, Orie Nakamura, Kazumi Ishidoh, Yoshimi Yamamoto, Satoru Yamagami, Manabu Mochizuki. Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells. Invest. Ophthalmol. Vis. Sci.. 2011.04; 52 (5): 2598-2605. ( PubMed, DOI )

  19. Sunao Sugita, Norio Shimizu, Ken Watanabe, Miki Katayama, Shintaro Horie, Manabu Ogawa, Hiroshi Takase, Yoshiharu Sugamoto, Manabu Mochizuki. Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. Br J Ophthalmol. 2011.03; 95 (3): 345-349. ( PubMed, DOI )

  20. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Manabu Mochizuki. Inhibition of B-cell activation by retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci.. 2010.11; 51 (11): 5783-5788. ( PubMed, DOI )

  21. Masaru Miyanaga, Tatsushi Kawaguchi, Kazunori Miyata, Shintaro Horie, Manabu Mochizuki, Carl P Herbort. Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. Jpn. J. Ophthalmol.. 2010.09; 54 (5): 377-382. ( PubMed, DOI )

  22. Shintaro Horie, Sunao Sugita, Yuri Futagami, Yukiko Yamada, Manabu Mochizuki. Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells. Clin. Immunol.. 2010.07; 136 (1): 83-95. ( PubMed, DOI )

  23. Sunao Sugita, Shintaro Horie, Yukiko Yamada, Hiroshi Keino, Yoshihiko Usui, Masaru Takeuchi, Manabu Mochizuki. Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2529-2536. ( PubMed, DOI )

  24. Yukiko Yamada, Sunao Sugita, Shintaro Horie, Satoru Yamagami, Manabu Mochizuki. Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta. Invest. Ophthalmol. Vis. Sci.. 2010.05; 51 (5): 2548-2557. ( PubMed, DOI )

  25. Tatsushi Kawaguchi, Shintaro Horie, Nadia Bouchenaki, Kyoko Ohno-Matsui, Manabu Mochizuki, Carl P Herbort. Suboptimal therapy controls clinically apparent disease but not subclinical progression of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2010.02; 30 (1): 41-50. ( PubMed, DOI )

  26. Sunao Sugita, Shintaro Horie, Orie Nakamura, Kazuichi Maruyama, Hiroshi Takase, Yoshihiko Usui, Masaru Takeuchi, Kazumi Ishidoh, Masato Koike, Yasuo Uchiyama, Christoph Peters, Yoshimi Yamamoto, Manabu Mochizuki. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J. Immunol.. 2009.10; 183 (8): 5013-5022. ( PubMed, DOI )

  27. Shintaro Horie, Sunao Sugita, Yuri Futagami, Tastushi Kawaguchi, Koju Kamoi, Shiroaki Shirato, Manabu Mochizuki. Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction. Exp. Eye Res.. 2009.06; 88 (6): 1033-1042. ( PubMed, DOI )

  28. Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Hiroyuki Aburatani, Taku Okazaki, Tasuku Honjo, Masaru Takeuchi, Manabu Mochizuki. T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest. Ophthalmol. Vis. Sci.. 2009.06; 50 (6): 2862-2870. ( PubMed, DOI )

  29. Sunao Sugita, Yoshihiko Usui, Shintaro Horie, Yuri Futagami, Yukiko Yamada, Juan Ma, Takeshi Kezuka, Hirofumi Hamada, Tomohiko Usui, Manabu Mochizuki, Satoru Yamagami. Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism. Invest. Ophthalmol. Vis. Sci.. 2009.01; 50 (1): 263-272. ( PubMed, DOI )

  30. Sunao Sugita, Shintaro Horie, Orie Nakamura, Yuri Futagami, Hiroshi Takase, Hiroshi Keino, Hiroyuki Aburatani, Nobuhiko Katunuma, Kazumi Ishidoh, Yoshimi Yamamoto, Manabu Mochizuki. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J. Immunol.. 2008.12; 181 (11): 7525-7536. ( PubMed )

  31. Sunao Sugita, Yuri Futagami, Shintaro Horie, Manabu Mochizuki. Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions. Exp. Eye Res.. 2007.11; 85 (5): 626-636. ( PubMed, DOI )

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Others 【 display / non-display 】

  • Blue is the clue to evaluating diabetic retinopathy，2021.10

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