Graduating School 【 display / non-display 】

Graduating School 【 display / non-display 】

• Okayama University, Faculty of Medicine, 1992.03, Graduated

Graduate School 【 display / non-display 】

Graduate School 【 display / non-display 】

• Okayama University, Graduate School, Division of Medicine, Doctor's Course, 1997.03, Completed

Campus Career 【 display / non-display 】

Campus Career 【 display / non-display 】

• 2011.06

  -

  Now

  Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Systems BioMedicine， Professor

External Career 【 display / non-display 】

External Career 【 display / non-display 】

• 2004

  -

  2010

  , Director
• 1992

  -

  1997

  , Senior Resident

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Molecular biology

• Orthopaedic surgery

• System genome science

• Developmental biology

Qualification Acquired 【 display / non-display 】

Qualification Acquired 【 display / non-display 】

• Doctor

Published Papers & Misc 【 display / non-display 】

Published Papers & Misc 【 display / non-display 】

• Gracey E, Burssens A, Cambre I, Schett G, Lories R, McInnes I, Asahara H, Elewaut D. . From molecular mechanobiology to structural macroanatomy: the role of mechanical loading intendon and ligament associated disease. Nat Rev Rheumatol. 2020.02;

• Carmen Adriaens, Florian Rambow, Greet Bervoets, Toomas Silla, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa, Torben Heick Jensen, Jean-Christophe Marine. The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 2019.12; 25 (12): 1681-1695. ( PubMed, DOI )

• Momo Isobe, Hikaru Toya, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa. Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 2019.12; ( PubMed, DOI )

• Yutaro Uchida, Tomoki Chiba, Ryota Kurimoto, Hiroshi Asahara. Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs. J. Biochem.. 2019.11; 166 (5): 375-382. ( PubMed, DOI )

• Satoshi Yamashita, Kensuke Kataoka, Hiroto Yamamoto, Tomoko Kato, Satoshi Hara, Katsushi Yamaguchi, Claire Renard-Guillet, Yuki Katou, Katsuhiko Shirahige, Haruki Ochi, Hajime Ogino, Tokujiro Uchida, Masafumi Inui, Shuji Takada, Shuji Shigenobu, Hiroshi Asahara. Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken. Sci Rep. 2019.08; 9 (1): 12560. ( PubMed, DOI )

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Books etc 【 display / non-display 】

Books etc 【 display / non-display 】

• Mokuda Sho, Olmer Merissa, Lotz Martin K., Sugiyama Eiji, Asahara Hiroshi . 骨と軟骨の生物学　WWドメイン含有タンパク質2(Wwp2)はmiR-140と協働して軟骨の恒常性を維持する(Bone and Cartilage Biology　WW domain-containing protein 2(Wwp2) maintains cartilage homeostasis in coordination with miR-140) . (一社)日本リウマチ学会， 2019.03

• Ito Y, Mokuda S, Miyata K, Matsushima T, Asahara H*. . Chronic Inflammation (Chapter 6). Springer， 2016.11 MicroRNAs in Chronic Inflammation Diseases.

Conference Activities & Talks 【 display / non-display 】

Conference Activities & Talks 【 display / non-display 】

• 淺原弘嗣. Mechano-signal on tendon and ligament homeostasis via Mkx. International Symposium on AMED “Mechanobiology” Project 2020.02.08

• 淺原弘嗣. 腱・靱帯をモデルとした細胞内・外メカノ・シグナルの解明とその応用によるバイオ靱帯の創出. AMED革新的先端研究開発支援事業（AMED-CREST,PRIME）「メカノバイオ」領域　令和元年度　領域会議 2020.02.06

• 淺原弘嗣. Homeostasis of tendons and ligaments connecting musculoskeletal system. Japan Bone Academy2019 2019.12.15

• Hiroshi Asahara. Characterization of a novel Sox9 enhancer and down-stream targets with implications in Arthritis parthenogenesis and therapeutics.. SOX meeting2019 2019.10.01

• 淺原弘嗣. Lecture I“Cartilage homeostasis and arthritis pathogenesis via RNA regulation”. 16th Meeting of Bone Biology Forum 2019.08.16

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