Personnel Information

写真a

ASAHARA Hiroshi


Job title

Professor

Mail Address

asahara.syst@tmd.ac.jp

Research Areas, Keywords

Basic Medicine, Molecular Biology, Developmental Regenerative Medicine, System Biology, Orthopedic Surgery, Rheumatology

Graduating School 【 display / non-display

  • Okayama University, Faculty of Medicine, 1992.03, Graduated

Graduate School 【 display / non-display

  • Okayama University, Graduate School, Division of Medicine, Doctor's Course, 1997.03, Completed

Campus Career 【 display / non-display

  • 2011.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Systems BioMedicine, Professor

External Career 【 display / non-display

  • 2004
    -
    2010
    , Director
  • 1992
    -
    1997
    , Senior Resident

Research Areas 【 display / non-display

  • Molecular biology

  • Orthopaedic surgery

  • System genome science

  • Developmental biology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  • Gracey E, Burssens A, Cambre I, Schett G, Lories R, McInnes I, Asahara H, Elewaut D. . From molecular mechanobiology to structural macroanatomy: the role of mechanical loading intendon and ligament associated disease. Nat Rev Rheumatol. 2020.02;

  • Carmen Adriaens, Florian Rambow, Greet Bervoets, Toomas Silla, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa, Torben Heick Jensen, Jean-Christophe Marine. The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 2019.12; 25 (12): 1681-1695. ( PubMed, DOI )

  • Momo Isobe, Hikaru Toya, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa. Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 2019.12; ( PubMed, DOI )

  • Yutaro Uchida, Tomoki Chiba, Ryota Kurimoto, Hiroshi Asahara. Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs. J. Biochem.. 2019.11; 166 (5): 375-382. ( PubMed, DOI )

  • Satoshi Yamashita, Kensuke Kataoka, Hiroto Yamamoto, Tomoko Kato, Satoshi Hara, Katsushi Yamaguchi, Claire Renard-Guillet, Yuki Katou, Katsuhiko Shirahige, Haruki Ochi, Hajime Ogino, Tokujiro Uchida, Masafumi Inui, Shuji Takada, Shuji Shigenobu, Hiroshi Asahara. Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken. Sci Rep. 2019.08; 9 (1): 12560. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Mokuda Sho, Olmer Merissa, Lotz Martin K., Sugiyama Eiji, Asahara Hiroshi . 骨と軟骨の生物学 WWドメイン含有タンパク質2(Wwp2)はmiR-140と協働して軟骨の恒常性を維持する(Bone and Cartilage Biology WW domain-containing protein 2(Wwp2) maintains cartilage homeostasis in coordination with miR-140) . (一社)日本リウマチ学会, 2019.03

  • Ito Y, Mokuda S, Miyata K, Matsushima T, Asahara H*. . Chronic Inflammation (Chapter 6). Springer, 2016.11 MicroRNAs in Chronic Inflammation Diseases.

Conference Activities & Talks 【 display / non-display

  • 淺原弘嗣. Mechano-signal on tendon and ligament homeostasis via Mkx. International Symposium on AMED “Mechanobiology” Project 2020.02.08

  • 淺原弘嗣. 腱・靱帯をモデルとした細胞内・外メカノ・シグナルの解明とその応用によるバイオ靱帯の創出. AMED革新的先端研究開発支援事業(AMED-CREST,PRIME)「メカノバイオ」領域 令和元年度 領域会議 2020.02.06

  • 淺原弘嗣. Homeostasis of tendons and ligaments connecting musculoskeletal system. Japan Bone Academy2019 2019.12.15

  • Hiroshi Asahara. Characterization of a novel Sox9 enhancer and down-stream targets with implications in Arthritis parthenogenesis and therapeutics.. SOX meeting2019 2019.10.01

  • 淺原弘嗣. Lecture I“Cartilage homeostasis and arthritis pathogenesis via RNA regulation”. 16th Meeting of Bone Biology Forum 2019.08.16

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