Personnel Information

写真a

TANIMOTO Kousuke


Job title

Project Junior Associate Professor

Birth date

1979

Mail Address

The inquiry by e-mail is 《here》
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Graduating School 【 display / non-display 】

  • Kyushu University, Faculty of Engineering, 2003, Graduated

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Graduate School 【 display / non-display 】

  • Kyushu University, Graduate School of Engineering, Master's Course, 2005, Completed

  • The University of Tokyo, Graduate School of Frontier Sciences, Doctor's Course, 2010, Accomplished credits for doctoral program

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Degree 【 display / non-display 】

  • Ph.D., The University of Tokyo

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Campus Career 【 display / non-display 】

  • 2011.04
    -
    2022.03
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Technology Laboratory， Genome Laboratory， Assistant Professor
  • 2022.04
    -
    2023.03
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Core， Assistant Professor
  • 2024.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Environmental Response， -， Project Junior Associate Professor
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External Career 【 display / non-display 】

  • 2023.04
    -
    2024.04
    Radiation Effects Research Foundation, Laboratory of Immunology, Department of Molecular Biosciences, Associate Senior Scientist
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Academic Society Affiliations 【 display / non-display 】

  • The molecular biology society of Japan

  • The Japanese Society of Virology

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Research Areas 【 display / non-display 】

  • Genome biology

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Published Papers & Misc 【 display / non-display 】

  1. Yasuyuki Kurihara, Takayuki Honda, Akira Takemoto, Katsutoshi Seto, Satoshi Endo, Kousuke Tanimoto, Susumu Kirimura, Masashi Kobayashi, Shunichi Baba, Yasuhiro Nakashima, Ryo Wakejima, Rie Sakakibara, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo. Immunohistochemistry of p53 surrogates TP53 mutation as an accurate predictor for early-relapse of surgically resected stage I-III lung adenocarcinoma JTCVS Open. 2024.08; ( DOI )

  2. Hajime Tanaka, Yuki Fukawa, Kouhei Yamamoto, Kousuke Tanimoto, Akira Takemoto, Takayasu Mori, Hisashi Hasumi, Mayumi Kinoshita, Takumi Kanazawa, Asuka Furukawa, Koichiro Kimura, Hiroyuki Sato, Akihiro Hirakawa, Shohei Fukuda, Yuma Waseda, Soichiro Yoshida, Steven C Campbell, Yasuhisa Fujii. Prognostic impact and genomic backgrounds of renal parenchymal infiltration or micronodular spread in non-metastatic clear cell renal cell carcinoma. Mod Pathol. 2024.08; 100590. ( PubMed, DOI )

  3. Naoya Murao, Taito Matsuda, Hisae Kadowaki, Yosuke Matsushita, Kousuke Tanimoto, Toyomasa Katagiri, Kinichi Nakashima, Hideki Nishitoh. The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis. EMBO Rep. 2024.07; ( PubMed, DOI )

  4. Hilary Osaka, Yasuaki Tagashira, Hiroaki Takeuchi, Yukie Tanaka, Kousuke Tanimoto, Yoshiaki Gu. Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature. Jpn J Infect Dis. 2024.05; ( PubMed, DOI )

  5. Takayuki Honda, Katsutoshi Seto, Satoshi Endo, Akira Takemoto, Kousuke Tanimoto, Masashi Kobayashi, Masatake Kitano, Rie Sakakibara, Takahiro Mitsumura, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo. The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non-small cell lung cancer. Cancer Med. 2023.10; 12 (19): 19406-19413. ( PubMed, DOI )

  6. Yuna Takatsuki, Yuta Takahashi, Jun Nakajima, Yumi Iwasaki, Katsutoshi Nagano, Chihiro Tani-Sassa, Sonoka Yuasa, Saki Kanehira, Kazunari Sonobe, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Naoya Ichimura, Shuji Tohda. Viral load of SARS-CoV-2 Omicron BA.5 is lower than that of BA.2 despite the higher infectivity of BA.5. Immun Inflamm Dis. 2023.02; 11 (2): e783. ( PubMed, DOI )

  7. Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda, Hiroaki Takeuchi. 4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells. Biochem Biophys Res Commun. 2023.01; 641 139-147. ( PubMed, DOI )

  8. Taro Fujikawa, Kousuke Tanimoto, Yoshiyuki Kawashima, Taku Ito, Keiji Honda, Takamori Takeda, Akane Sonobe, Natsuki Aoki, Jing Bai, Takeshi Tsutsumi. Cholesteatoma has an altered microbiota with a higher abundance of Staphylococcus species Laryngoscope Investig Otolaryngol. 2022.12; 7 (6): 2011-2019. ( PubMed, DOI )

  9. Sonoka Yuasa, Jun Nakajima, Yuna Takatsuki, Yuta Takahashi, Chihiro Tani-Sassa, Yumi Iwasaki, Katsutoshi Nagano, Kazunari Sonobe, Tomoyo Yoshimoto, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Naoya Ichimura, Shuji Tohda. Viral load of SARS-CoV-2 Omicron is not high despite its high infectivity. J Med Virol. 2022.11; 94 (11): 5543-5546. ( PubMed, DOI )

  10. Chihiro Tani-Sassa, Yumi Iwasaki, Naoya Ichimura, Katsutoshi Nagano, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda. Viral loads and profile of the patients infected with SARS-CoV-2 Delta, Alpha, or R.1 variants in Tokyo. J Med Virol. 2022.04; 94 (4): 1707-1710. ( PubMed, DOI )

  11. Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura. Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy. Hum Genome Var. 2022.02; 9 (1): 6. ( PubMed, DOI )

  12. Seiya Oba, Tadashi Hosoya, Miki Amamiya, Takahiro Mitsumura, Daisuke Kawata, Hirokazu Sasaki, Mari Kamiya, Akio Yamamoto, Takahiro Ando, Sho Shimada, Tsuyoshi Shirai, Tsukasa Okamoto, Tomoya Tateishi, Akira Endo, Junichi Aiboshi, Nobuyuki Nosaka, Hideo Yamanouchi, Toyomu Ugawa, Eiki Nagaoka, Keiji Oi, Susumu Tao, Yasuhiro Maejima, Yukie Tanaka, Kousuke Tanimoto, Hiroaki Takeuchi, Shuji Tohda, Akihiro Hirakawa, Tetsuo Sasano, Hirokuni Arai, Yasuhiro Otomo, Yasunari Miyazaki, Shinsuke Yasuda. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Front Cardiovasc Med. 2021.11; 8 767074. ( PubMed, DOI )

  13. Chang Liu, Yasuyuki Gen, Kousuke Tanimoto, Tomoki Muramatsu, Jun Inoue, Johji Inazawa. Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells. Mol Ther Nucleic Acids. 2021.09; 25 83-92. ( PubMed, DOI )

  14. Akira Takemoto, Kousuke Tanimoto, Seiichi Mori, Jun Inoue, Naoto Fujiwara, Tetsuo Noda, Johji Inazawa. Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma. Cancer Science. 2021.07; ( PubMed, DOI )

  15. Katsutoshi Nagano, Chihiro Tani-Sassa, Yumi Iwasaki, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Naoya Ichimura, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda. SARS-CoV-2 R.1 lineage variants that prevailed in Tokyo in March 2021. J Med Virol. 2021.07; ( PubMed, DOI )

  16. Kousuke Tanimoto, Taeko K Naruse, Tetsuro Matano, Akinori Kimura. Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer. Immunogenetics. 2021.04; 73 (2): 175-186. ( PubMed, DOI )

  17. Takagawa Yuki, Gen Yasuyuki, Muramatsu Tomoki, Tanimoto Kousuke, Inoue Jun, Harada Hiroyuki, Inazawa Johji. miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway MOLECULAR THERAPY. 2020.06; 28 (6): 1494-1505. ( PubMed, DOI )

  18. Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life Science Alliance. 2020.03; 3 (3): ( PubMed, DOI )

  19. Kousuke Tanimoto, Tomoki Muramatsu, Johji Inazawa. Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas. Cancer Med. 2019.10; ( PubMed, DOI )

  20. Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura. Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction. J. Hum. Genet.. 2018.09; ( PubMed, DOI )

  21. Takeharu Hayashi, Kousuke Tanimoto, Kayoko Hirayama-Yamada, Etsuko Tsuda, Mamoru Ayusawa, Shinichi Nunoda, Akira Hosaki, Akinori Kimura. Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy. J. Hum. Genet.. 2018.06; ( PubMed, DOI )

  22. Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018.04; ( PubMed, DOI )

  23. Tonouchi E, Gen Y, Muramatsu T, Hiramoto H, Tanimoto K, Inoue J, Inazawa J. miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein. Scientific reports. 2018.03; 8 (1): 4482. ( PubMed, DOI )

  24. Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017.08; 12 (8): e0181791. ( PubMed, DOI )

  25. Hiroaki Nagata, Ken-Ichi Kozaki, Tomoki Muramatsu, Hidekazu Hiramoto, Kousuke Tanimoto, Naoto Fujiwara, Seiya Imoto, Daisuke Ichikawa, Eigo Otsuji, Satoru Miyano, Tatsuyuki Kawano, Johji Inazawa. Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma. Oncotarget. 2017.06; 8 (23): 37740-37750. ( PubMed, DOI )

  26. Hidekazu Hiramoto, Tomoki Muramatsu, Daisuke Ichikawa, Kousuke Tanimoto, Satoru Yasukawa, Eigo Otsuji, Johji Inazawa. miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer. Sci Rep. 2017.06; 7 (1): 4002. ( PubMed, DOI )

  27. Yu Oikawa, Kei-Ichi Morita, Kou Kayamori, Kousuke Tanimoto, Kei Sakamoto, Hiroto Katoh, Shumpei Ishikawa, Johji Inazawa, Hiroyuki Harada. Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma. Cancer Sci.. 2017.02; 108 (2): 256-266. ( PubMed, DOI )

  28. Daisuke Kikuchi, Kousuke Tanimoto, Koh Nakayama. CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK. Biochem. Biophys. Res. Commun.. 2016.01; 469 (2): 243-250. ( PubMed, DOI )

  29. Mai Nanya, Masaki Sato, Kousuke Tanimoto, Minoru Tozuka, Shuki Mizutani, Masatoshi Takagi. Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells. PLoS ONE. 2015.12; 10 (12): e0144540. ( PubMed, DOI )

  30. Kei-ichi Morita, Takuya Naruto, Kousuke Tanimoto, Chisato Yasukawa, Yu Oikawa, Kiyoshi Masuda, Issei Imoto, Johji Inazawa, Ken Omura, Hiroyuki Harada. Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome. PLoS ONE. 2015.11; 10 (11): e0140480. ( PubMed, DOI )

  31. Naoto Fujiwara, Jun Inoue, Tatsuyuki Kawano, Kousuke Tanimoto, Ken-Ichi Kozaki, Johji Inazawa. miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity. Cancer Res.. 2015.09; 75 (18): 3890-3901. ( PubMed, DOI )

  32. Sotaro Kanematsu, Kousuke Tanimoto, Yutaka Suzuki, Sumio Sugano. Screening for possible miRNA-mRNA associations in a colon cancer cell line. Gene. 2014.01; 533 (2): 520-531. ( PubMed, DOI )

  33. Mayuko Furuta, Ken-ichi Kozaki, Kousuke Tanimoto, Shinji Tanaka, Shigeki Arii, Teppei Shimamura, Atsushi Niida, Satoru Miyano, Johji Inazawa. The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS ONE. 2013.03; 8 (3): e60155. ( PubMed, DOI )

  34. Akinori Kanai, Kenta Suzuki, Kousuke Tanimoto, Junko Mizushima-Sugano, Yutaka Suzuki, Sumio Sugano. Characterization of STAT6 target genes in human B cells and lung epithelial cells. DNA Res.. 2011.10; 18 (5): 379-392. ( PubMed, DOI )

  35. Riu Yamashita, Nuankanya P Sathira, Akinori Kanai, Kousuke Tanimoto, Takako Arauchi, Yoshiaki Tanaka, Shin-Ichi Hashimoto, Sumio Sugano, Kenta Nakai, Yutaka Suzuki. Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis. Genome Res.. 2011.05; 21 (5): 775-789. ( PubMed, DOI )

  36. Kousuke Tanimoto, Katsuya Tsuchihara, Akinori Kanai, Takako Arauchi, Hiroyasu Esumi, Yutaka Suzuki, Sumio Sugano. Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing. Hugo J. 2010.12; 4 (1-4): 35-48. ( PubMed, DOI )

  37. Nuankanya Sathira, Riu Yamashita, Kousuke Tanimoto, Akinori Kanai, Takako Arauchi, Soutaro Kanematsu, Kenta Nakai, Yutaka Suzuki, Sumio Sugano. Characterization of transcription start sites of putative non-coding RNAs by multifaceted use of massively paralleled sequencer. DNA Res.. 2010.06; 17 (3): 169-183. ( PubMed, DOI )

  38. Katsuya Tsuchihara, Yutaka Suzuki, Hiroyuki Wakaguri, Takuma Irie, Kousuke Tanimoto, Shin-ichi Hashimoto, Kouji Matsushima, Junko Mizushima-Sugano, Riu Yamashita, Kenta Nakai, David Bentley, Hiroyasu Esumi, Sumio Sugano. Massive transcriptional start site analysis of human genes in hypoxia cells. Nucleic Acids Res.. 2009.04; 37 (7): 2249-2263. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Ryo Kudo, Yoshihito Kano, Rika Noji, Ryota Kakuta, Iichiro Onishi, Kouichiro Kimura, Kousuke Tanimoto, Fuyuki Miya, Takahiro Mitsumura, Noriko Oshima, Yousuke Ariizumi, Tsuyoshi Nakagawa, Toshiaki Ishikawa, Satoshi Miyake, Sadakatsu Ikeda. MO28-5 Clinical utility of comprehensive genomic profiling for patients with cancer of unknown primary site. 2022 the Japanese Society of Medical Oncology Annual Meeting 17–19 February 2022, Kyoto, Japan 2022.02.17 Kyoto, Japan

  2. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver（Canada）

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Campus class subject 【 display / non-display 】

  • Cancer genomics and precision medicine，2019

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Performance of duties 【 display / non-display 】

  • ，2011.04 - Now

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