Personnel Information

写真a

ISHIGURO Taro


Job title

Assistant Professor

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

neurodegeneration
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2001, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2009, Completed

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Degree 【 display / non-display 】

  • medicine, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2011.04
    -
    2016.02
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Assistant Professor
  • 2014.04
    -
    2016.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Assistant Professor
  • 2019.04
    -
    2019.10
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2019.11
    -
    2020.01
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2020.02
    -
    2020.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2020.04
    -
    2021.05
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2021.06
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Assistant Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Neurology, Neurosurgery, Psychiatry, and Anesthesiology， Neurology， Assistant Professor

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External Career 【 display / non-display 】

  • 2016.04
    -
    2019.03
    Mayo Clinic Florida, Department of Neuroscience, Senior Research Fellow
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Research Areas 【 display / non-display 】

  • Neurology

  • Neuroscience-general

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Published Papers & Misc 【 display / non-display 】

  1. Nishida Y, Ishiguro T, Yokota T. Tap-Elicited Clonus of the Biceps and Triceps Brachii. JAMA neurology. 2022.02; 79 (2): 194. ( PubMed, DOI )

  2. Iwase R, Ishiguro T, Fujita K, Ishibashi S, Yokota T. Dupilumab for Atopic Dermatitis, a Possible Risk Factor of Juvenile Ischemic Stroke: A Case Report. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2020.06; 29 (6): 104763. ( PubMed, DOI )

  3. Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor P., Pearson C. E., Charlet-Berguerand N., Mizusawa H., Nagai Y., Ishikawa K.. Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 56. ( DOI )

  4. Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.. Repeat associated non-atg translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 717. ( DOI )

  5. Ishiguro Taro, Sato Nozomu, Ueyama Morio, Fujikake Nobuhiro, Sellier Chantal, Kanegami Akemi, Tokuda Eiichi, Zamiri Bita, Gall-Duncan Terence, Mirceta Mila, Furukawa Yoshiaki, Yokota Takanori, Wada Keiji, Taylor J. Paul, Pearson Christopher E., Charlet-Berguerand Nicolas, Mizusawa Hidehiro, Nagai Yoshitaka, Ishikawa Kinya. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 NEURON. 2017.04; 94 (1): 108-+. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Ueyama Morio, Ishiguro Taro, Ozawa Daisaku, Sugiki Toshihiko, Ishiguro Akira, Tokuda Eiichi, Konno Takuya, Koyama Akihide, Takeuchi Toshihide, Furukawa Yoshiaki, Fujiwara Toshimichi, Wada Keiji, Onodera Osamu, Nagai Yoshitaka. Regulation of RAN translation by RBP1 that modulates the structure of G4C2 repeat RNA in C9-ALS/FTD(和訳中). 臨床神経学 2021.09.01

  2. Miura Motoki, Sakaue Fumika, Ishiguro Taro, Iwase Ryo, Sano Tatsuhiko, Hara Rintaro, Wada Takeshi, Nagata Tetsuya, Yokota Takanori. TDP-43-specific aptamer rescues ALS phenotype in TDP-43 transgenic mice(和訳中). 臨床神経学 2021.09.01

  3. Higashi Miwa, Okita Michi, Aoki Hanako, Ishii Takashi, Nagata Tetsuya, Ishiguro Taro, Yokota Takanori, Ishikawa Kinya. What are the roles of TGGAA penta-nucleotide repeats as bidirectional transcripts in SCA31?(和訳中). 臨床神経学 2021.09.01

  4. Higashi Miwa, Okita Michi, Sato Nozomu, Asaka Meiko, Ishii Takashi, Aoki Hanako, Ishiguro Taro, Yanagihara Dai, Yokota Takanori, Ishikawa Kinya. SCA31トランスジェニックマウスはヒトの患者と類似した病理学的特徴を示す(SCA31 transgenic mice show pathologic features similar to human patients). 臨床神経学 2020.11.01

  5. Iwase Ryo, Sanjo Nobuo, Ishiguro Taro, Yokota Takanori. 脳表シデローシスにおける稀な筋萎縮の臨床的特徴と病態生理(Clinical characteristics and pathophysiology of a rare muscle atrophy in superficial siderosis). 臨床神経学 2020.11.01

  6. Ishikawa Kinya, Higashi Miwa, Okita Michi, Aoki Hanako, Asaka Meiko, Ishiguro Taro, Sato Nozomu, Nagai Yoshitaka, Yanagihara Dai, Yokota Takanori. 日本から世界へのSCAに関する最初の発見や治療　脊髄小脳失調症31型(SCA31)の病状形成機序(Original discovery and therapy for SCA from Japan to the world　Pathogenesis of spinocerebellar ataxia type 31(SCA31)). 臨床神経学 2020.11.01

  7. Ishiguro Taro, Yokota Takanori, Ishikawa Kinya, Nagai Yoshitaka, Petrucelli Leonard. ショウジョウバエのSpt4ノックダウンはSCA31関連の伸長UGGAAリピート誘発毒性を抑制する(Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila). 臨床神経学 2019.11.01

  8. Ishikawa Kinya, Ishiguro Taro, Nagai Yoshitaka. 神経疾患の克服を目指して　SCA31　分子病態とRNAシャペロンの役割(SCA31: molecular pathogenesis and role of RNA chaperone). 臨床神経学 2018.12.01

  9. Taro Ishiguro. Expanded UGGAA repeat RNA associated with SCA31 causes progressive neurodegeneration in Drosophila.. Symposium : Non-coding repeat diseases - underlying pathogenesis in RNA and protein metabolism; The 38th Annual Meeting of the Japan Neuroscience Society 2015.07.29

  10. T. Ishiguro, N. Fujikake, N. Sato, M. Ueyama, H. Mizusawa, K. Wada, Y. Nagai, K. Ishikawa. Expanded UGGAA repeat RNA associated with SCA31 causes progressive neurodegeneration in Drosophila.. Cold Spring Horbor Laboratory Meeting 2014.12.03

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