Personnel Information

写真a

KOBAYASHI Yukiho


Job title

Assistant Professor

Birth date

1974

Mail Address

yukiho-kobayashi.mort@tmd.ac.jp

Research Areas, Keywords

Orthodontics, craniosynostosis, congenital anomalies, bone metabolism

Graduating School 【 display / non-display

  • The University of Tokushima, Faculty of Dentistry, 1999, Graduated

Graduate School 【 display / non-display

  • The University of Tokushima, Graduate School, Division of Dental Research, Doctor's Course, 2003, Completed

Degree 【 display / non-display

  • D.D.S., Ph.D, The University of Tokushima

Campus Career 【 display / non-display

  • 2010.09
    -
    2013.03
    Tokyo Medical and Dental University, Hard Tissue Genome Research Center, Project Assistant Professor
  • 2013.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Orthognathics, Assistant Professor
  • 2018.04
    -
    2022.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Orthognathics, Assistant Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Clinical Dentistry, Department of Oral, Maxillofacial Growth and Development, Orthodontics, Assistant Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Orthognathics, Assistant Professor

Academic Society Affiliations 【 display / non-display

  • IADR

Research Areas 【 display / non-display

  • Developmental dentistry

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  1. Myo AC, Kobayashi Y, Niki Y, Kamimoto H, Moriyama K. Exosome-mediated small interfering RNA delivery inhibits aberrant osteoblast differentiation in Apert syndrome model mice. Archives of Oral Biology. 2023.09; 153 105753. ( PubMed, DOI )

  2. Jindarojanakul P, Kobayashi Y, Kamimoto H, Niki Y, Chan Myo A, Satrawaha S, Moriyama K. Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells. European Journal of Orthodontics. 2023.03; ( PubMed, DOI )

  3. Inoue A, Tsuji M , Baba Y, Moriyama K. Non-prosthetic treatment using segmental osteotomy and bone grafting in a patient with cleft lip and palate Plastic and Aesthetic Research. 2022.09; 9 51. ( DOI )

  4. OguraK, Kobayashi Y, Hikita R, Tsuji M, Moriyama K. Three-dimensional analysis of the palatal morphology in growing patients with Apert syndrome and Crouzon syndrome. Congenital Anomalies (Kyoto). 2022.07; 62 (4): 153-160. ( PubMed, DOI )

  5. Niki Y, Kobayashi Y, Moriyama K. Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth Gene Expression Patterns. 2021.06; 40 119182. ( DOI )

  6. Miyazaki T, Kurimoto R, Chiba T, Matsushima T, Nakamichi R, Tsutsumi H, Takada K, Yagasaki L, Kato T, Shishido K, Kobayashi Y, Matsumoto T, Moriyama K, Asahara H. Mkx regulates the orthodontic tooth movement via osteoclast induction. Journal of Bone and Mineral Metabolism. 2021.05; ( PubMed, DOI )

  7. Min Swe NM, Kobayashi Y, Kamimoto H, Moriyama K. Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2 S252W /+ ) mouse model Developmental Dynamics. 2020.08; ( PubMed, DOI )

  8. Kobayashi Y, Ogura K, Hikita R, Tsuji M, Moriyama K. Craniofacial, oral, and cervical morphological characteristics in Japanese patients with Apert syndrome or Crouzon syndrome. European Journal of Orthodontics. 2020.03; ( PubMed, DOI )

  9. Kamimoto H, Kobayashi Y, Moriyama K. Relaxin 2 carried by magnetically directed liposomes accelerates rat midpalatal suture expansion and subsequent new bone formation. Bone Reports. 2019.06; 10 100202. ( PubMed, DOI )

  10. Veistinen LK, Mustonen T, Hasan MR, Takatalo M, Kobayashi Y, Kesper DA, Vortkamp A, Rice DP. Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. Frontiers in Physiology. 2017.12; 8 1036. ( PubMed, DOI )

  11. Duarte C, Kobayashi Y, Morita J, Kawamoto T, Moriyama K. A preliminary investigation of the effect of relaxin on bone remodelling in suture expansion. The European Journal of Orthodontics. 2017.06; 39 (3): 227-234. ( PubMed, DOI )

  12. Duarte C, Kobayashi Y, Kawamoto T, Moriyama K.. RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro. Bone.. 2014.08;

  13. Yokota M, Kobayashi Y, Morita J, Suzuki H, Hashimoto Y, Sasaki Y, Akiyoshi K, Moriyama K.. Therapeutic effect of nanogel-based delivery of soluble FGFR2 with S252W mutation on craniosynostosis. PLoS One.. 2014.07;

  14. Hikita R, Kobayashi Y, Tsuji M, Kawamoto T, Moriyama K.. Long-term orthodontic and surgical treatment and stability of a patient with Beckwith-Wiedemann syndrome. Am J Orthod Dentofacial Orthop.. 2014.05;

  15. Morita J, Nakamura M, Kobayashi Y, Deng CX, Funato N, Moriyama K.. Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model. Dev Dyn. . 2014.04;

  16. Duarte C, Kobayashi Y, Kawamoto T, Moriyama K.. Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice. Arch Oral Biol. . 2014.02;

  17. Suzuki H, Suda N, Shiga M, Kobayashi Y, Nakamura M, Iseki S, Moriyama K.. Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts. J Cell Physiol. . 2012.09;

  18. Tanimoto Y, Veistinen L, Alakurtti K, Takatalo M, Rice DP.. Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). J Biol Chem. . 2012.06;

  19. Veistinen L, Takatalo M, Tanimoto Y, Kesper DA, Vortkamp A, Rice DP.. Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. Front Physiol.. 2012.05;

  20. Rice DP, Connor EC, Veltmaat JM, Lana-Elola E, Veistinen L, Tanimoto Y, Bellusci S, Rice R. Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet. 2010.09; 19 (17): 3457-3467. ( PubMed, DOI )

  21. Miraoui H, Oudina K, Petite H, Tanimoto Y, Moriyama K, Marie PJ. Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J Biol Chem. 2009.02; 284 (8): 4897-4904. ( PubMed, DOI )

  22. Kinouchi N, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Tanimoto Y, Moriyama K, Noji S. Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass. Gene Ther. 2008.08; 15 (15): 1126-1130. ( PubMed, DOI )

  23. Tanimoto Y, Yokozeki M, Hiura K, Matsumoto K, Nakanishi H, Matsumoto T, Marie PJ, Moriyama K. A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome. J Biol Chem. 2004.10; 279 (44): 45926-45934. ( PubMed, DOI )

  24. Matsumoto K, Nakanishi H, Koizumi Y, Seike T, Tanimoto Y, Yokozeki M, Hiura K, Moriyama K, Minami M, Urano Y, Hirabayashi S. Correction of a deformed thumb by distraction of the phalanx. Scand J Plast Reconstr Surg Hand Surg. 2002; 36 (6): 368-372. ( PubMed )

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Books etc 【 display / non-display

  1. Kobayashi Y, Duarte C, Moriyama K. Biomarkers in Bone Disease. Part of the series Biomarkers in Disease: Methods, Discoveries and Applications. Springer, 2017.07 15.Hormone Relaxin as Biomarker for Bone Health and Disease. (ISBN : 978-94-007-7692-0)

  2. Kobayashi Y, Duarte C, Moriyama K.. Biomarkers in Bone Disease. Part of the series Biomarkers in Disease: Methods, Discoveries and Applications. 2016.07 Hormone Relaxin as Biomarker for Bone Health and Disease. (ISBN : 978-94-007-7745-3)

Conference Activities & Talks 【 display / non-display

  1. Sodsook W, Kobayashi Y, Kamimoto H, Niki Y, Chantarawaratit P, Moriyama K. Roles of B-Cell Lymphoma 6 in Orthodontic Tooth Movement. 2024 IADR/AADOCR/CADR General Session & Exhibition 2024.03.13 New Orleans, LA, USA

  2. Liu Lu, Kobayashi Y, Moriyama K. SASP senescent cells induces FGR/FGFR2 binding in coronal suture of Apert syndrome mice. TMDU-WISEリトリート2023 2023.11.29 静岡

  3. Sodsook W, Kobayashi Y, Kamimoto H, Niki Y, Chantarawaratit P, Moriyama K. Roles of B-cell lymphoma 6 (BCL6) in orthodontic tooth movement of rat molars. The 82nd Annual Meeting of the Japanese Orthodontic Society 2023.11.01 Niigata

  4. Lu Y, Kobayashi Y, Niki Y, Moriyama K. Analysis of SOD3 expression patterns under hypoxia during tooth development in mice. The 82nd Annual Meeting of the Japanese Orthodontic Society 2023.11.01 Niigata

  5. Myo AC, Kobayashi Y, Niki Y, Kamimoto H, Moriyama K. Exosome-mediated small interfering RNA delivery inhibits aberrant osteoblast differentiation caused by FGFR2 activation in Apert syndrome model mice. 98th European Orthodontic Society Congress 2023.06.11 Oslo, Norway

  6. Myo AC, Kobayashi Y, Niki Y, Kamimoto H, Moriyama K. Exosome-mediated siRNA inhibits aberrant osteoblast differentiation in Apert syndrome model mice. The 47th Annual Meeting of Japanese Cleft Palate Association 2023.05.25 Tokyo

  7. Jindarojanakul P, Kobayashi Y, Kamimoto H, Satraha S, Moriyama K. Sod3 regulates periodontal tissue remodeling through ROS modulation during orthodontic tooth movement of rat molars. 第80回日本矯正歯科学会学術大会&第5回国際会議 2021.11.03

  8. Niki Y, Kobayashi Y, Moriyama K . Expression pattern of transcriptional enhanced associate domain family member 1 in the developing mouse molar tooth . EOS 2021 Annual Virtual Conference 2021.07.02 ondemand

  9. Teramoto A, Sagawa Y, Akiyama S, Funahashi K, Kobayashi Y, Moriyama K. Interdisciplinary Approach for an Adult Orthodontic Patient with Angle Class III Malocclusion Complicated with Severe Periodontitis. The 9th Internarional Orthodontic Congress, The 12th Asian Pacific Orthodontic Conference, The 79th Annual Meeting of the Japanese Orthodontic Society 2020.10.04 ondemad

  10. Niki Y, Kobayashi Y, Moriyama K. Expression pattern of transcriptional enhanced associate domain family member 1in developing mouse molar tooth. The 9th Internarional Orthodontic Congress, The 12th Asian Pacific Orthodontic Conference, The 79th Annual Meeting of the Japanese Orthodontic Society 2020.10.04 ondemand

  11. Funahashi K, Kobayashi Y, Niki Y, Higashihori N, Nakakuki K,Yoda T, Moriyama K. A Case Report of Severe Class II Malocclusion Treated with Anterior Segmental Maxillary Osteotomy and Genioplasty. The 9th Internarional Orthodontic Congress, The 12th Asian Pacific Orthodontic Conference, The 79th Annual Meeting of the Japanese Orthodontic Society 2020.10.04 ondemand

  12. Kobayashi Y, Minswe NM, Kamimoto H, Moriyama K. Aberrant Wnt/β-catenin Signaling in Coronal Sutures of Apert Mouse Model. The 9th Internarional Orthodontic Congress, The 12th Asian Pacific Orthodontic Conference, The 79th Annual Meeting of the Japanese Orthodontic Society 2020.10.04 ondemand

  13. Minswe NM, Kobayashi Y, Kamimoto H, Moriyama K . Aberrant Wnt/β-catenin Signaling in Coronal Sutures of Apert Mouse Model. 2020 IADR/AADR/CADR General Session 2020.03.18 special online only issue of the Journal of Dental Research

  14. Minswe NM, Kobayashi Y, Kamimoto H, Moriyama K. Aberrant activation of Wnt/β-catenin signaling in the coronal sutures of an Apert syndrome mouse model. 第78回日本矯正歯科学会学術大会 2019.11.20 長崎県長崎市

  15. Tsuji M, Shoji A, Hirabayashi K, Kobayashi Y, Moriyama K. Analysis of dentocraniofacial morphology in patients with achondroplasia. 第59回日本先天異常学会・The 13th World Congress of International Cleft Lip and Palate oundation CLEFT 2019 ICPF合同学術集会 2019.07.26 愛知県名古屋市

  16. Ogura K, Kobayashi Y, Hikita R, Shoji A, Tsuji M, Moriyama K. Analysis of palatal morphology of craniosynostosis patients: Comparison between Apert syndrome and Crouzon syndrome . The 11th Asian Pacific Orthodontic Conference(APOC 2018) 2018.03.05 Boracay, Phillipines

  17. Megumi Arimura,Yuko Komazaki,Jun J Miyamoto,Kenji Ogura,Yukiho Kobayashi,Keiji Moriyama. Clinical study of Japanese Marfan syndrome patients: craniofacial morphology. The 49th Annual Scientific Congress,Korean Association of Orthodontists 2016.10.07 Korea

  18. Michiko Tsuji, Kenji Ogura, Rina Hikita, Yukiho Kobayashi,Keiji Moriyama. Maxillofacial morphological characteristics of two Japanese patients with chromosome 18p deletion syndrome. International Congress of Human Genetics 2016 2016.04.03 Kyoto

  19. Acceleration of osteoblastic cell differentiation and mineralization by fibroblast growth factor receptor(FGFR)2 with Apert mutation.. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and Japan Bone and Mineral Society. (15th Conference of the IBMS 2003

  20. Fibroblast growth factor receptor 2 with apert mutation (S252W) increase osteoblast differentiation and mineralization.. 24th Annual Meeting American Society for Bone and Mineral Research. 2002

  21. Enhanced differentiation in Apert osteoblastic cells with FGFR2 S252W mutation.. 79th General Session of The International Association for Dental Research. 2001

  22. Molecular cloning and characterization of FGFR2 in osteoblast-like cells derived from an Apert syndrome patient.. 23rd Annual Meeting American Society for Bone and Mineral Research. 2001

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Awards & Honors 【 display / non-display

  • The JOS Young Investigatiors Award,2005

  • Travel grant award (1st Joint Meeting of the International Bone and Mineral Society (IBMS) and Japan Bone and Mineral Society. (15th Conference of the IBMS),2003