Personnel Information

写真a

UNUMA Kana


Job title

Professor

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, JAPAN

Laboratory Phone number

+81-3-5803-5199

Laboratory Fax number

+81-3-5803-0128

Mail Address

unumlegm@tmd.ac.jp

Research Areas, Keywords

Forensic pathology, Forensic toxicology, toxic substance, cocaine, Thallium

Field Introduction URL

https://www.tmd.ac.jp/med/legm/index.html

To the head of this page.▲

Degree 【 display / non-display 】

  • M.D., Ph.D., The University of Tokyo

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2013.09
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Junior Associate Professor
  • 2018.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Junior Associate Professor
  • 2021.04
    -
    2024.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Junior Associate Professor
  • 2024.04
    -
    2024.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Associate Professor
  • 2024.08
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Public Health， Department of Forensic Medicine， Professor

▼display all

To the head of this page.▲

External Career 【 display / non-display 】

  • Physician's License in Japan, number 439040,
  • New Mexico Office of the Medical Investigator, research fellow
To the head of this page.▲

Qualification Acquired 【 display / non-display 】

  • Doctor

To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  1. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma. Thallium induces metallothionein gene expression in Huh-7 human hepatoma cells. Toxicology. 2025.06; 514 154121. ( PubMed, DOI )

  2. Nagano S, Makino Y, Jarrell HS, Arai N, Yoshii T, Unuma K.. Fatal spontaneous spinal subdural hematoma in a patient on anticoagulant therapy. J Forensic Sci.. 2025.05; ( DOI )

  3. Toshihiko Aki, Kana Unuma. Cocaine abuse and its impact on the thymus and spleen. Histol Histopathol. 2025.03; 18904. ( PubMed, DOI )

  4. Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma. Aristolochic acid-induced DNA adduct formation triggers acute DNA damage response in rat kidney proximal tubular cells. Toxicol Lett. 2025.02; 406 1-8. ( PubMed, DOI )

  5. Kana Unuma, Shuheng Wen, Sho Sugahara, Shutaro Nagano, Toshihiko Aki, Tadayuki Ogawa, Shino Takeda-Homma, Masakazu Oikawa, Akihiro Tojo. Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats. Arch Toxicol. 2024.10; ( PubMed, DOI )

  6. Shuheng Wen, Yohsuke Makino, Motoki Inaji, Nobutaka Arai, Kana Unuma. Importance of repeated computed tomography on pediatric traumatic acute posterior fossa subdural hematoma: A case study. Leg Med (Tokyo). 2024.06; 70 102466. ( PubMed, DOI )

  7. Hikari Tachibana, Moeka Nomura, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemura. Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940. Neurotoxicology. 2024.06; 103 215-221. ( PubMed, DOI )

  8. Shutaro Nagano, Kana Unuma, Toshihiko Aki, Koichi Uemura. N-acetylcysteine alleviates arsenic trioxide-induced reductions in hepatic catalase gene expression both in vitro and in vivo. Leg Med (Tokyo). 2024.05; 69 102458. ( PubMed, DOI )

  9. Shutaro Nagano, Kana Unuma, Yohsuke Makino, Hiroki Mori, Koichi Uemura. Acute upper airway obstruction due to cervical hematoma after cervicofacial liposuction. J Forensic Leg Med. 2024.05; 104 102697. ( PubMed, DOI )

  10. Sho Sugahara, Kana Unuma, Shuheng Wen, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. PLoS One. 2024; 19 (12): e0311884. ( PubMed, DOI )

  11. Moeka Nomura, Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochem Biophys Res Commun. 2023.12; 695 149438. ( PubMed, DOI )

  12. Kana Unuma, Shuheng Wen, Toshihiko Aki, Koichi Uemura. Ectopic myogenesis and fibrosis accompany adipogenesis during thymic involution induced by repeated cocaine administration. Biochem Biophys Res Commun. 2023.12; 686 149201. ( PubMed, DOI )

  13. Shuheng Wen, Kana Unuma, Ryoichi Hanazawa, Shutaro Nagano, Ryo Watanabe, Akihiro Hirakawa, Koichi Uemura. Alcohol and toxicological factors influencing fatal falls from height in the Greater Tokyo Area: a retrospective study. Int J Legal Med. 2023.11; ( PubMed, DOI )

  14. Shuheng Wen, Kana Unuma, Motoki Inaji, Yohsuke Makino, Shutaro Nagano, Kazuki Harada, Nobutaka Arai, Koichi Uemura. Case report: Fatal ischemic stroke induced by unruptured traumatic intracranial vertebral artery dissection. Front Neurol. 2023.09; 14 1202698. ( PubMed, DOI )

  15. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling. Biochem Biophys Res Commun. 2023.07; 676 30-35. ( PubMed, DOI )

  16. Shuheng Wen, Kana Unuma, Koichi Uemura, Kazuki Harada. Revisiting the canonical definition of heat hematoma: A rare case of postmortem subdural heat hematoma. J Forensic Leg Med. 2023.07; 98 102563. ( PubMed, DOI )

  17. Toshihiko Aki, Hiroki Tanaka, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochem Biophys Res Commun. 2023.07; 676 66-72. ( PubMed, DOI )

  18. Kana Unuma, Hiroyuki Sato, Shuheng Wen, Yohsuke Makino, Akihiro Hirakawa, Koichi Uemura. The proportion of false-positives in positive Seratec® prostate-specific antigen SemiQuant test results in postmortem screening for seminal fluid. Leg Med (Tokyo). 2023.05; 62 102243. ( PubMed, DOI )

  19. Unuma Kana, Sato Hiroyuki, Wen Shuheng, Makino Yohsuke, Hirakawa Akihiro, Uemura Koichi. 精液の死後スクリーニングでSeratec PSA SemiQuant検査において陽性判定から検出された偽陽性の割合(The proportion of false-positives in positive Seratec prostate-specific antigen SemiQuant test results in postmortem screening for seminal fluid) Legal Medicine. 2023.05; 62 1-4. ( ichushi )

  20. Toshihiko Aki, Mitsuki Kukita, Mao Takata, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure. Biochem Biophys Res Commun. 2023.04; 651 92-97. ( PubMed, DOI )

  21. Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2023.03; 378 39-50. ( PubMed, DOI )

  22. Toya M, Minegishi S, Utsuno H, Ohta J, Namiki S, Unuma K, Uemura K, Sakurada K. Forensic Characteristics of Physical Elder Abuse and Current Status and Issues of Collaboration between Forensic Medicine Departments and Related Institutions in Japan. International journal of environmental research and public health. 2022.11; 19 (22): ( PubMed, DOI )

  23. Wen Shuheng, Unuma Kana, Watanabe Ryo, Uemura Koichi, Harada Kazuki. 見逃された外傷性頭蓋外椎骨動脈仮性動脈瘤による致死的なくも膜下出血　診断困難な高度外傷症例における法医学的評価(Fatal Subarachnoid Hemorrhage Due to Neglected Traumatic Extracranial Vertebral Artery Pseudoaneurysm: Forensic Assessment in a Difficult to Diagnosed Highly Decomposed Case) 法医学の実際と研究. 2022.11; (65): 161-166. ( ichushi )

  24. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022.10; 23 (19): ( PubMed, DOI )

  25. Makino Yohsuke, Unuma Kana, Nolte Kurt B., Adolphi Natalie L.. Accuracy of forensic pathologists in incorporating post-mortem CT (PMCT) in forensic death investigation JOURNAL OF FORENSIC SCIENCES. 2022.09; 67 (6): 2351-2359. ( PubMed, DOI )

  26. Wen Shuheng, Unuma Kana, Makino Yohsuke, Mori Hiroki, Uemura Koichi. Fatal consequence after MiraDry treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome(和訳中) Legal Medicine. 2022.09; 58 1-4. ( ichushi )

  27. Wen Shuheng, Unuma Kana, Uemura Koichi. Two fatal cases due to inadvertent discharge of carbon dioxide fire suppressant: Intoxication or asphyxiation? JOURNAL OF FORENSIC AND LEGAL MEDICINE. 2022.08; 90 102390. ( PubMed, DOI )

  28. Shuheng Wen, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. Int J Mol Sci. 2022.05; 23 (10): ( PubMed, DOI )

  29. Shuheng Wen, Kana Unuma, Yohsuke Makino, Hiroki Mori, Koichi Uemura. Fatal consequence after MiraDry® treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome. Leg Med (Tokyo). 2022.05; 58 102095. ( PubMed, DOI )

  30. Toshihiko Aki, Kana Unuma, Koichi Uemura. The Role of Peroxiredoxins in the Regulation of Sepsis. Antioxidants (Basel). 2022.01; 11 (1): ( PubMed, DOI )

  31. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis. 2022.01; 27 (1-2): 14-21. ( PubMed, DOI )

  32. Unuma K, Kaga H, Funakoshi T, Nomura M, Aki T, Uemura K. Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PloS one. 2022; 17 (11): e0277032. ( PubMed, DOI )

  33. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration. Sci Rep. 2021.12; 11 (1): 24129. ( PubMed, DOI )

  34. Shuheng Wen, Kana Unuma, Ryo Watanabe, Yohsuke Makino, Koichi Uemura. Forensic evaluation of fatal-suffocating retropharyngeal haematoma secondary to cervical fractures: Report of two cases. J Forensic Leg Med. 2021.11; 85 102274. ( PubMed, DOI )

  35. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi. Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report (vol 51, 101878, 2021) LEGAL MEDICINE. 2021.09; 52 101936. ( PubMed, DOI )

  36. Kana Unuma, Yohsuke Makino, Kouhei Yamamoto, Shinya Hattori, Nobutaka Arai, Kentaro Sakai, Masanobu Kitagawa, Koichi Uemura, Hirokazu Kanegane. Fatal intracranial hemorrhage due to infantile acute lymphoblastic leukemia mimicking abusive head trauma. J Forensic Sci. 2021.07; 66 (6): 2504-2510. ( PubMed, DOI )

  37. Atsushi Yamada, Kana Unuma, Nobutaka Arai, Osamu Kitamura, Koichi Uemura. Inappropriate diet and fatal malnutrition in a 10-year-old child fed only infant formula throughout life: Novel pathological diagnostic criterion for starvation via lipophagy. Forensic Sci Int. 2021.07; 325 110896. ( PubMed, DOI )

  38. Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2021.07; 350 240-248. ( PubMed, DOI )

  39. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi. セツキシマブ初回投与後のα-Gal症候群による致死的アナフィラキシー　法医学的事例の初報告例(Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report) Legal Medicine. 2021.07; 51 1-4. ( ichushi )

  40. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi. Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report LEGAL MEDICINE. 2021.07; 51 101878. ( PubMed, DOI )

  41. Shuheng Wen, Kana Unuma, Ryo Watanabe, Koichi Uemura. Diagnosis by forensic autopsy of cannula malposition resulting in fatal tension pneumothorax after attempted percutaneous tracheostomy: A short communication. J Forensic Leg Med. 2021.05; 81 102177. ( PubMed, DOI )

  42. Tatsuya Norii, Yohsuke Makino, Kana Unuma, Natalie L Adolphi, Danielle Albright, David P Sklar, Cameron Crandall, Darren Braude. CT imaging of extraglottic airway device-pictorial review. Emerg Radiol. 2021.02; 28 (3): 665-673. ( PubMed, DOI )

  43. Tatsuya Norii, Yohsuke Makino, Kana Unuma, Gary M Hatch, Natalie L Adolphi, Sarah Dallo, Danielle Albright, David P Sklar, Darren Braude. Extraglottic Airway Device Misplacement: A Novel Classification System and Findings in Postmortem Computed Tomography. Ann Emerg Med. 2021.01; 77 (3): 285-295. ( PubMed, DOI )

  44. Moeka Nomura, Kana Unuma, Toshihiko Aki, Koichi Uemura. Sustained splenic contraction after daily cocaine administration in rats. PLoS One. 2021; 16 (6): e0252853. ( PubMed, DOI )

  45. Tetsushi Kitayama, Takashi Fukagawa, Haruhiko Watahiki, Yusuke Mita, Koji Fujii, Kana Unuma, Koichi Sakurada, Koichi Uemura, Kazumasa Sekiguchi, Natsuko Mizuno. Evaluation of Rapid DNA system for buccal swab and disaster victim identification samples. Leg Med (Tokyo). 2020.09; 46 101713. ( PubMed, DOI )

  46. Kitayama Tetsushi, Fukagawa Takashi, Watahiki Haruhiko, Mita Yusuke, Fujii Koji, Unuma Kana, Sakurada Koichi, Uemura Koichi, Sekiguchi Kazumasa, Mizuno Natsuko. 口腔粘膜細胞スワブと被災者の身元確認試料に対するRapid DNAシステムの評価(Evaluation of Rapid DNA system for buccal swab and disaster victim identification samples) Legal Medicine. 2020.09; 46 1-8. ( ichushi )

  47. Kana Unuma, Ryo Watanabe, Naho Hirayama, Koichi Uemura. Autopsy Identification of Viable Mycobacterium Tuberculosis in the Lungs of a Markedly Decomposed Body. J. Forensic Sci.. 2020.08; 65 (6): 2194-2197. ( PubMed, DOI )

  48. Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells. Sci Rep. 2020.06; 10 (1): 10581. ( PubMed, DOI )

  49. Joji Kunihiro, Hiroaki Nabeka, Hiroyuki Wakisaka, Kana Unuma, Md Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Kimiko Yamamiya, Shouichiro Saito, Fumihiko Hamada, Seiji Matsuda. Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection. PLoS One. 2020; 15 (12): e0241315. ( PubMed, DOI )

  50. Shuheng Wen, Toshihiko Aki, Kana Unuma, Koichi Uemura. Chemically Induced Models of Parkinson's Disease: History and Perspectives for the Involvement of Ferroptosis. Front Cell Neurosci. 2020; 14 581191. ( PubMed, DOI )

  51. Kana Unuma, Ayaka Yoshikawa, Toshihiko Aki, Koichi Uemura. Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137. J Toxicol Pathol. 2019.10; 32 (4): 305-310. ( PubMed, DOI )

  52. Unuma Kana, Yoshikawa Ayaka, Aki Toshihiko, Uemura Koichi. 敗血症モデルラットにおける血中ペルオキシレドキシン4の上昇は肝細胞からの分泌と関連し、GYY4137によって軽減する(Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137) Journal of Toxicologic Pathology. 2019.10; 32 (4): 305-310. ( ichushi )

  53. Kana Unuma, Yohsuke Makino, Yoshiyuki Sasaki, Hirotaro Iwase, Koichi Uemura.. Presepsin: A potential superior diagnostic biomarker for the postmortem differentiation of sepsis based on the Sepsis-3 criteria Forensic Science International. 2019.06; 299 17-20. ( PubMed, DOI )

  54. Kana Unuma, Toshihiko Aki, Ayaka Yamashita, Ayaka Yoshikawa, Koichi Uemura. Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats. J Toxicol Sci. 2019; 44 (2): 107-112. ( PubMed, DOI )

  55. Toshihiko Aki, Kana Unuma, Kanako Noritake, Naho Hirayama, Takeshi Funakoshi, Koichi Uemura. Formation of high molecular weight p62 by CORM-3. PLoS ONE. 2019; 14 (1): e0210474. ( PubMed, DOI )

  56. Unuma Kana, Aki Toshihiko, Yamashita Ayaka, Yoshikawa Ayaka, Uemura Koichi. Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats JOURNAL OF TOXICOLOGICAL SCIENCES. 2019; 44 (1-3): 107-112.

  57. Unuma Kana, Aki Toshihiko, Yamashita Ayaka, Yoshikawa Ayaka, Uemura Koichi. 硫化水素ドナーであるNaHSは、ラットの気道分泌物増加を伴う気管支炎を誘発する(Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats) The Journal of Toxicological Sciences. 2019; 44 (1-3): 107-112. ( ichushi )

  58. Toshihiko Aki, Kana Unuma, Kanako Noritake, Hatsumi Kurahashi, Takeshi Funakoshi, Koichi Uemura. Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin. Toxicol In Vitro. 2018.03; 50 201-209. ( PubMed, DOI )

  59. Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci. 2018.03; 43 (3): 193-202. ( PubMed, DOI )

  60. Hirayama Naho, Aki Toshihiko, Funakoshi Takeshi, Noritake Kanako, Unuma Kana, Uemura Koichi. パラコートに曝露したヒト神経細胞の壊死(Necrosis in human neuronal cells exposed to paraquat) The Journal of Toxicological Sciences. 2018.03; 43 (1-3): 193-202. ( ichushi )

  61. Kana Unuma, Toshihiko Aki, Suguru Nagano, Ryo Watanabe, Koichi Uemura. The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem. Biophys. Res. Commun.. 2018.01; 495 (2): 1668-1674. ( PubMed, DOI )

  62. Toshihiko Aki, Kana Unuma, and Koichi Uemura. Emerging roles of mitochondria and autophagy in liver injury during sepsis. Cell Stress. 2017.11; 1 (2): 79-89.

  63. Kanako Noritake, Toshihiko Aki, Moe Kimura, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017.10; 42 (5): 545-551. ( PubMed, DOI )

  64. Watanabe Ryo, Unuma Kana, Noritake Kanako, Funakoshi Takeshi, Aki Toshihiko, Uemura Koichi. 三酸化ヒ素投与ラットの脳におけるDNA損傷反応の毛細血管拡張性運動失調症およびrad3関連(ATR)-前骨髄球性白血病蛋白質(PML)経路(Ataxia telangiectasia and rad3 related(ATR)-promyelocytic leukemia protein(PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide) Journal of Toxicologic Pathology. 2017.10; 30 (4): 333-337. ( ichushi )

  65. Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura. A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem. Biophys. Res. Commun.. 2017.06; 487 (3): 748-754. ( PubMed, DOI )

  66. Watanabe, R; Unuma, K; Noritake, K; Funakoshi, T; Aki, T; Uemura, K. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pahway of the DNA damage response in the brain of rats administered arsenic trioxide JOURNAL OF TOXICOLOGIC PATHOLOGY. 2017; 30 (4): 333-337. ( PubMed, DOI )

  67. Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. J Biol Chem.. 2016.11; 291 (48): 25050-25065. ( PubMed, DOI )

  68. Yusuke Fujii, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Toshihiko Aki, Koichi Uemura. Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016.09; 41 (5): 645-654. ( PubMed, DOI )

  69. Watanabe M, Unuma K, Makino Y, Komatsu A, Yamada A, Nagai H, Uemura K. An Autopsy Case of Asphyxia Caused by Uncontrolled Hemorrhage Following Transbronchial Lung Biopsy J Clin Respir Dis Care. 2016.07; ( DOI )

  70. Haruka Kimura-Kojima, Kana Unuma, Takeshi Funakoshi, Chizuru Kato, Ayumi Komatsu, Toshihiko Aki, Koichi Uemura. Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. J Toxicol Pathol. 2016.04; 29 (2): 131-138. ( PubMed, DOI )

  71. Kyoko Uchida, Kana Unuma, Koichi Uemura. A fatality in a child with severe fatty liver due to n-butane and isopentane poisoning resulting from long-term inhalation of an antiperspirant aerosol. Forensic Sci Med Pathol. 2015.12; 11 (4): 631-632. ( PubMed, DOI )

  72. Ryohei Kuroda, Kaori Shintani-Ishida, Kana Unuma, Ken-ichi Yoshida. Immobilization Stress With α2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. Int Heart J. 2015.09; 56 (5): 537-543. ( PubMed, DOI )

  73. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Kyoko Hashimoto, Koichi Uemura. Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy. 2015.09; 11 (9): 1520-1536. ( PubMed, DOI )

  74. Kanako Noritake, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015.08; 10 (8): e0136952. ( PubMed, DOI )

  75. Mayumi Watanabe, Kana Unuma, Yohsuke Makino, Kanako Noritake, Atsushi Yamada, Hirotaro Iwase, Koichi Uemura. An Autopsy Case of Acute Massive Hematochezia Caused by Superior Mesenteric Vein Thrombosis: A First Report in Forensic Medicine. J. Forensic Sci.. 2015.08; ( PubMed, DOI )

  76. Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Koichi Uemura. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015.03; 10 (3): e0120192. ( PubMed, DOI )

  77. Mayumi Watanabe, Kana Unuma, Yusuke Fujii, Kanako Noritake, Koichi Uemura. An autopsy case of vagus nerve stimulation following acupuncture. Leg Med (Tokyo). 2015.03; 17 (2): 120-122. ( PubMed, DOI )

  78. Sayuri Okawa, Kana Unuma, Atsushi Yamada, Toshihiko Aki, Koichi Uemura. Lipopolysaccharide induces expression of collagen VI in the rat lung. J Toxicol Pathol. 2015.01; 28 (1): 37-41. ( PubMed, DOI )

  79. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014.08; 322 43-50. ( PubMed, DOI )

  80. Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, Uchiyama Y, Yoshida K.. Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol Res.. 2014.07; 44 (7): 779-787.

  81. Uchida K, Unuma K, Funakoshi T, Aki T, Uemura K. Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea. J Toxicol Pathol. 2014.07; 27 (2): 153-158. ( PubMed, DOI )

  82. Yamada A, Unuma K, Kojima H, Uemura K.. Subarachnoid hemorrhage caused by a traffic accident: de novo aneurysm ruptured 30 years after surgical neck clipping. J Forensic Leg Med. . 2014.02; 22 90-92.

  83. Kana Unuma, Kazuki Harada, Teruaki Oka, Koichi Uemura. Starch accumulation in the lungs of two infants following positive ventilation. Forensic Sci Med Pathol. 2013.12; 9 (4): 554-557. ( PubMed, DOI )

  84. Izumi Funakoshi-Hirose, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Kanako Noritake, Koichi Uemura. Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology. 2013.10; 312 74-82. ( PubMed, DOI )

  85. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Impairment of autophagy: from hereditary disorder to drug intoxication. Toxicology. 2013.09; 311 (3): 205-215. ( PubMed, DOI )

  86. Marie Bessho, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Chizuru Kato, Koichi Uemura. Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells. Cardiovasc Toxicol. 2013.09; 13 (3): 267-277. ( PubMed, DOI )

  87. Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-Ichi Yoshida, Koichi Uemura. Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat. Hepatol Res. 2013.05; 43 (5): 526-534. ( PubMed, DOI )

  88. Unuma K, Aki T, Funakoshi T, Yoshida K, Uemura K.. Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart. PLoS One.. 2013.02; 8 (2): e56526. ( DOI )

  89. Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-Ichi Yoshida, Koichi Uemura. Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res. 2013.01; 43 (1): 91-96. ( PubMed, DOI )

  90. Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N.. Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model. PLoS One.. 2013.01; 8 (1): e55514. ( DOI )

  91. Funakoshi T, Aki T, Unuma K, Uemura K. Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells. Brain Res. 2013.01; 1490 9-22. ( PubMed, DOI )

  92. Noritake K, Aki T, Funakoshi T, Unuma K, Nara A, Kato C, Uemura K. Critical roles of Rho-associated kinase in membrane blebbing and mitochondrial pathway of apoptosis caused by 1-butanol. Toxicol In Vitro. 2012.09; 26 (6): 849-855. ( PubMed, DOI )

  93. Bessho M, Unuma K, Nara A, Uemura K. A case in which a bone fragment caused by a bullet made a second channel in addition to the bullet channel. Leg Med (Tokyo). 2012.07; 14 (4): 188-190. ( PubMed, DOI )

  94. Nara A, Aki T, Funakoshi T, Unuma K, Uemura K. Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res. 2012.07; 1466 1-14. ( PubMed, DOI )

  95. Unuma K, Uozaki H, Kuroda R, Uemura K, Yoshida K. Death from axillary haemorrhage during haemodialysis in a patient with a history of microscopic polyangiitis. BMJ Case Rep. 2012.01; 2012 ( PubMed, DOI )

  96. Ryohei Kuroda, Kazuki Harada, Takashi Kobayashi, Hisashi Nagai, Kana Unuma, Kanju Saka, Kaori Shintani-Ishida, Ken-ichi Yoshida. Sudden cardiac death caused by the administration of a β₂-agonist for asthma attack. Int J Cardiol. 2011.12; 153 (3): e56-e58. ( PubMed, DOI )

  97. Unuma K, Harada K, Funakoshi T, Uemura K.. Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus). Forensic Sci Int. 2011.11; 10 (212(1-3)): e15-7.

  98. Noritake K, Unuma K, Nara A, Uchida K, Shiratori T, Watanuki Y, Funakoshi T, Uemura K. Autopsy findings of a patient with rapidly progressive massive ascites caused by alcoholic cirrhosis. Legal medicine (Tokyo, Japan). 2011.01; ( PubMed, DOI )

  99. Unuma K, Harada K, Furutani M, Furutani Y, Nakajima M, Nakanishi T, Matsuoka R, Yoshida KI. Multiple stenotic arteriopathy in a 72-year-old female with Williams syndrome. Journal of clinical pathology. 2011.01; ( PubMed, DOI )

  100. Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K. Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart. Circ J. 2010.11; 74 (12): 2693-2701. ( PubMed )

  101. Unuma K, Harada K, Nakajima M, Ito T, Okutsu K, Yoshida K. Unexpected death of a patient with rheumatoid arthritis complicated by a cervical deformity. Leg Med (Tokyo). 2010.09; 12 (5): 242-245. ( PubMed, DOI )

  102. Tojo A, Unuma K, Harada K, Yoshida K, Fujita T. Localization and mechanism of nephrocalcinosis in pseudo-Bartter's syndrome. Kidney Int. 2010.05; 77 (9): 831; author reply 831. ( PubMed, DOI )

  103. Unuma K, Shintani-Ishida K, Tsushima K, Shimosawa T, Ueyama T, Kuwahara M, Yoshida K. Connexin-43 redistribution and gap junction activation during forced restraint protects against sudden arrhythmic death in rats. Circ J. 2010.05; 74 (6): 1087-1095. ( PubMed )

  104. Unuma K, Harada K, Nakajima M, Eguchi H, Tsushima K, Ito T, Shintani-Ishida K, Kojima H, Yoshida K. Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication. Forensic Sci Int. 2010.01; 194 (1-3): e5-8. ( PubMed, DOI )

  105. Nakajima M, Kojima H, Takazawa Y, Yahagi N, Harada K, Takahashi K, Unuma K, Yoshida K. An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan. J Clin Pathol. 2009.11; 62 (11): 1029-1033. ( PubMed, DOI )

  106. Saka K, Konuma K, Asai S, Unuma K, Nakajima M, Yoshida K. Identification of active ingredients in dietary supplements using non-destructive mass spectrometry and liquid chromatography-mass spectrometry. Forensic Sci Int. 2009.10; 191 (1-3): e5-10. ( PubMed, DOI )

  107. Shintani-Ishida K, Unuma K, Yoshida K. Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion. Circ J. 2009.09; 73 (9): 1661-1668. ( PubMed )

  108. Unuma K, Tojo A, Harada K, Saka K, Nakajima M, Ishii T, Fujita T, Yoshida K. Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills. BMJ Case Report. 2009.03; ( DOI )

  109. Uemura K, Ueyama T, Shintani-Ishida K, Unuma K, Yoshida K. An autopsy report on four sudden cardiac death cases by immobilization. Int Med J. 2008; 15 301-305.

  110. Unuma K, Chen J, Saito S, Kobayashi N, Sato K, Saito K, Wakisaka H, Mominoki K, Sano A, Matsuda S. Changes in expression of prosaposin in the rat facial nerve nucleus after facial nerve transection. Neurosci Res. 2005.07; 52 (3): 220-227. ( PubMed, DOI )

▼display all

To the head of this page.▲

Books etc 【 display / non-display 】

  1. Toshihiko Aki, Kanako Noritake, Kana Unuma, and Koichi Uemura. “Autophagy in health and disease”, “Stem Cell Biology and Regenerative Medicine” book series. Humana press, Springer-Nature， 2018 Autophagic regulation of cardiomyocyte survival and heart regeneration. (ISBN : 978-3-319-98145-1)

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. 長野修太郎, 渡邊嶺, 鵜沼香奈. スワドル着用中の乳児突然死 -臨床への還元とその課題-. 第93回日本法医学会学術関東地方会 2024.10.12

  2. 須賀原 翔, 鵜沼 香奈, 温 書恒, 藤乘 嗣泰. 硫酸タリウム中毒における腎障害のメカニズム(Mechanism of Renal Injury in Thallium Sulfate Intoxication). 日本腎臓学会誌 2024.06.01

  3. 鵜沼香奈. 刑事事件の法医鑑定における 神経病理学的検索の実際 (シンポジウム：今こそ頭部外傷の神経病理について考えよう－司法制度におけるその重要性と将来の展望－). 第65回日本神経病理学会総会学術研究会 2024

  4. Moeka Nomura、Kana Unuma、Toshihiko Aki、Koichi Uemura. Effects of 7 days daily cocaine administration on the spleen and brain of rats. 2022.06.09

  5. Makino Yohsuke, Unuma Kana, Adolphi Natalie, Nolte K.B.. The Evaluation of the Routine Use of Postmortem Computed Tomography (PMCT) In a High-Volume United States Medical Examiner’s Office. the Academy’s 73rdAnnual Scientific Meeting 2021.02.15 CST-USA

  6. 渡邊 嶺、鵜沼 香奈、秋 利彦、上村 公一. . ラット脳組織における三酸化二ヒ素のPML及びDNA損傷チェックポイント機構への影響.. 第91回日本生化学会大会 2018.09 京都

  7. Unuma Kana, Aki Toshihiko, Watanabe Ryo, Uemura Koichi. Down-regulation of cardiac contractile protein is involved in cardiac dysfunction during sepsis and is mitigated by carbon monoxide. 24th Congress of the International Academy of Legal Medicine (IALM) 2018.05.01

  8. 山田真嗣,　鵜沼香奈,　則竹香菜子,　小島遥,　小松亜由美,　上村公一. 乳幼児用調整粉乳のみで生育された小学男児の1剖検例. 第83回　日本法医学会学術関東地方集会 2014.11.08

  9. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura. Secretion of mitochondrial contents through autophagolysosomal exocytosis from lipopolysaccharide-stimulated hepatocytes and embryonic fibroblasts.. 9th International Symposium on Advances in Legal Medicine 2014.06.17 Fukuoka,Japan

  10. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of ubiquitin-proteasome system plays a protective role in arsenic trioxide-induced cardiotoxicity. 9th International Symposium on Advances in Legal Medicine 2014.06

  11. Harada K, Nakajima M, Unuma K, Shintani-ishida K, Kanawaku Y, Kohno A, Sato N, Kanetake J, Yoshida K. A muder case with an unusual grid-pattern postmortem dismemberment. 9th International Symposium on Advances in Legal Medicine 2014.06

  12. Watanabe M, Unuma K, Fujii Y, Noritake K, Uemura K. A fatal case of vagus nerve injury after acupuncture. 9th International Symposium on Advances in Legal Medicine 2014.06

  13. Akina Nara, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Methamphetamine-caused cytotoxic effects involves macropinocytosis in differentiated SH-SY5Y cells. 95次日本法医学会総会 2011.06.24

  14. 内田恭子, 鵜沼香奈, 船越丈司, 綿貫祐美, 上村公一. 市販の制汗剤の慢性的な吸引により著明な脂肪肝を呈した児童の1剖検例. 95次日本法医学会総会 2011.06.23

  15. 鵜沼　香奈. ラット顔面神経切断後の顔面神経核内プロサポシンの増加. 第106回日本解剖学会総会. 第106回日本解剖学会総会 2011.04.01

  16. 鵜沼香奈, 新谷香, 原田一樹, 中嶋信, 高橋麻衣子,吉田謙一.. ap Junctions play a protective role in cardiac disfunction of immobilization stress model.. 第92次日本法医学会総会 2008.06.23

  17. Unuma K, Shintani-Ishida K, Tsushima K, Shimozawa T, Yoshida K.. Effects of gap junction inhibitor on heart, in psychological stress-induced cardiac response in rat.. he 7th International Symposium Advances in Legal Medicine 2008.06.23

  18. Shintani-ishida K, Unuma K. Why is contraction band necrosis clustered exclusively within the ischemic area?. The 7th Symposium Advances in Legal Medicine. 2008.06.23

▼display all

To the head of this page.▲

Others 【 display / non-display 】

  • Kana Unuma, Hirokazu Kanegane. Molecular autopsy sheds light on cause of sudden death of a child with COVID-19，2023.04

To the head of this page.▲
 

Performance of duties 【 display / non-display 】

  • ，2010.04 - Now

To the head of this page.▲