Personnel Information

写真a

SEKIYA Ichiro


Job title

Professor

Birth date

1964

Laboratory Address

Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Laboratory Phone number

+81-3-5803-4017

Laboratory Fax number

+81-3-5803-0192

Mail Address

sekiya.arm@tmd.ac.jp

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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 1990, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medicine, Orthopaedic surgery, Doctor's Course, 2000, Completed

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Degree 【 display / non-display 】

  • PH,D, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 1900.01
    -
    2016.02
    Tokyo Medical and Dental University， Center for Stem Cell and Regenerative Medicine， Professor
  • 2009.06
    -
    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Stem Cell and Regenerative Medicine， Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Cell Therapy， Professor
  • 2014.10
    -
    Now
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Stem Cell and Regenerative Medicine， Director
  • 2014.10
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Applied Regenerative Medicine， Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Professor
  • 2017.05
    -
    2018.03
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Professor
  • 2018.04
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Transfusion Medicine and Cell Therapy， Director
  • 2020.10
    -
    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Integrated Facilities， Center for Transfusion Medicine and Cell Therapy， Director
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Center for Stem Cell and Regenerative Medicine， Professor

▼display all

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Research Areas 【 display / non-display 】

  • Orthopedics

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Published Papers & Misc 【 display / non-display 】

  1. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Naoki Kagi, Ichiro Sekiya. Operator-derived particles and falling bacteria in biosafety cabinets. Regenarative Therapy. 2024.03; 25 264-272. ( PubMed, DOI )

  2. Mitsuru Mizuno, Yoshitaka Maeda, Sho Sanami, Takahisa Matsuzaki, Hiroshi Y Yoshikawa, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Noninvasive total counting of cultured cells using a home-use scanner with a pattern sheet. iScience. 2024.03; 27 (3): 109170. ( PubMed, DOI )

  3. Yugo Miura, Kentaro Endo, Ichiro Sekiya. Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa. Tissue Cell. 2024.03; 88 102370. ( PubMed, DOI )

  4. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Takashi Hoshino, Masaki Amemiya, Ichiro Sekiya. Real-time virtual sonography-guided ossicle removal in unresolved Osgood-Schlatter disease Arthroscopy Techniques. 2024.01; ( DOI )

  5. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Keiichi Yano, Yukiko Ota, Kengo Tomita, Naoki Kagi, Ichiro Sekiya. Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators. Regen Ther. 2023.12; 24 211-218. ( PubMed, DOI )

  6. Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Kentaro Endo, Noriya Okanouchi 1,2, Jo Fujita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Morphological analysis of three-dimensional MR images of patellofemoral joints in asymptomatic subjects Sci Rep. 2023.12; 13 (1): 16570.

  7. Ichiro Sekiya, Hisako Katano, Ali Guermazi, Yugo Miura, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Yoshio Kitazume, Hideyuki Koga, Nobutake Ozeki. Association of AI-determined Kellgren-Lawrence grade with medial meniscus extrusion and cartilage thickness by AI-based 3D MRI analysis in early knee osteoarthritis. Sci Rep. 2023.11; 13 (1): 20093. ( PubMed, DOI )

  8. Zhu Ling, Hailati Aini, Shuhei Kajikawa, Jumpei Shirakawa, Kunikazu Tsuji, Yoshinori Asou, Hideyuki Koga, Ichiro Sekiya, Akira Nifuji, Masaki Noda, Yoichi Ezura. Mutation Are Treatable by Alendronate. Pharmaceuticals (Basel). 2023.10; 16 (10): ( PubMed, DOI )

  9. Hideto Furuoka, Kentaro Endo, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis. Stem Cell Res Ther. 2023.09; 14 (1): 244. ( PubMed, DOI )

  10. Shoichi Hasegawa, Yusuke Nakagawa, Aritoshi Yoshihara, Tomomasa Nakamura, Hiroki Katagiri, Masaya Hayashi, Hideya Yoshimura, Tsuyoshi Nagase, Ichiro Sekiya, Hideyuki Koga. Older Age, Poor Preoperative Quadriceps Muscle Strength, and Residual Pain as Risk Factors for Poor Quadriceps Muscle Strength Recovery at 1 Year After ACL Reconstruction: A TMDU MAKS Study of 402 Patients. Orthop J Sports Med. 2023.09; 11 (9): 23259671231194593. ( PubMed, DOI )

  11. Katagiri H, Nakagawa Y, Amano Y, Shirakawa Y, Ozeki N, Nakamura T, Sekiya I, Koga H. Decision regret following opening wedge high tibial osteotomy: Older age as a risk factor. The Knee. 2023.06; 43 62-69. ( PubMed, DOI )

  12. Amano Y, Ozeki N, Matsuda J, Nakamura T, Nakagawa Y, Sekiya I, Koga H. Augmentation of a Nonanatomical Repair of a Medial Meniscus Posterior Root Tear With Centralization Using Three Knotless Anchors May Be Associated With Less Meniscal Extrusion and Better Compressive Load Distribution in Mid-Flexion Compared With Non-Anatomical Root Repair Alone in a Porcine Knee Model. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2023.05; 39 (12): 2487-2498. ( PubMed, DOI )

  13. Hasegawa S, An JS, Hino J, Amano Y, Nakagawa Y, Miyatake K, Katagiri H, Nakamura T, Sekiya I, Koga H, Tsuji K. Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model. Journal of orthopaedic surgery (Hong Kong). 2023.05; 31 (2): 10225536231181708. ( PubMed, DOI )

  14. M Isono, H Koga, Y Nakagawa, T Nakamura, I Sekiya, H Katagiri. Inferior Healing Rate in Isolated Meniscal Repair than that in Meniscal Repair with Concomitant ACL Reconstruction Evaluated with MRI. Malays Orthop J. 2023.03; 17 (1): 61-69. ( PubMed, DOI )

  15. Mizuno Mitsuru, Yori Kouichirou, Takeuchi Toshikazu, Yamaguchi Tetsuya, Watanabe Ken, Tomaru Yasuhiro, Shimizu Norio, Sekiya Ichiro. Cross-contamination risk and decontamination during changeover after cell-product processing. Regenerative Therapy. 2023.03; 22 30-38. ( ichushi )

  16. Ozeki N, Mizuno M, Yanada S, Okada T, Kubota R, Kushida Y, Furuoka H, Endo K, Katano H, Nakamura K, Ohya S, Koga H, Sekiya I. Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model. Transplantation proceedings. 2023.03; 55 (2): 470-480. ( PubMed, DOI )

  17. Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes. BMC Mol Cell Biol. 2022.12; 23 (1): 53. ( PubMed, DOI )

  18. Mitsuru Mizuno,Yori K, Takeuchi T, Yamaguchi T, Watanabe K, Tomaru Y, Shimizu N, Sekiya I. Cross-contamination risk and decontamination during changeover after cell-product processing Regenerative Therapy. 2022.12; 22 30-38. ( PubMed, DOI )

  19. Yusuke Nakagawa, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Hiroki Katagiri, Nobutake Ozeki, Toshiyuki Ohara, Ichiro Sekiya, Takeshi Muneta, Toshifumi Watanabe. Mid-term clinical outcomes of a posterior stabilized total knee prosthesis for Japanese patients: A minimum follow-up of 5 years. J Orthop Sci. 2022.12; ( PubMed, DOI )

  20. Mizuno Mitsuru, Ozeki Nobutake, Sekiya Ichiro. 変形性関節症に対する細胞療法でトリソミー7を有する培養細胞を使用する場合の安全性(Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis) Regenerative Therapy. 2022.12; 21 81-86. ( ichushi )

  21. Fujii Shunichi, Endo Kentaro, Matsuta Seiya, Komori Keiichiro, Sekiya Ichiro. 膝蓋下脂肪体由来の脱分化型脂肪細胞と間葉系幹細胞の収量と特性の比較(Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads) Regenerative Therapy. 2022.12; 21 611-619. ( ichushi )

  22. Mizuno Mitsuru, Sugahara Yoshimi, Iwayama Daisuke, Miyashita Noe, Katano Hisako, Sekiya Ichiro. 細胞加工オペレーターのストレスとモチベーション　オンライン質問票調査のパイロット試験(Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey) Regenerative Therapy. 2022.12; 21 547-552. ( ichushi )

  23. Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Nobutake Ozeki, Takashi Hoshino, Masaki Amemiya, Ichiro Sekiya. Simultaneous Correction of Varus Deformity and Posterior Tibial Slope by Modified Hybrid Closed-Wedge High Tibial Osteotomy. Arthrosc Tech. 2022.11; 11 (11): e2081-e2089. ( PubMed, DOI )

  24. Mitsuru Mizuno, Yoshimi Sugahara, Daisuke Iwayama, Noe Miyashita, Hisako Katano, Ichiro Sekiya. Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey Regenerative Therapy. 2022.11; 21 547-552. ( PubMed, DOI )

  25. Shunichi Fujii, Kentaro Endo, Seiya Matsuda, Keiichiro Komori,Ichiro Sekiya. Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads Regenerative Therapy. 2022.11; 21 611-619. ( PubMed, DOI )

  26. Ichiro Sekiya, Nobutake Ozeki. The 16th International Workshop on Osteoarthritis Imaging:“New insightson treatment and imaging: A :couple that belongs together" Osteoarthritis Imaging. 2022.10; Volume 2 (Supplement 1):

  27. Takahiro Tanimoto, Kentaro Endo, Yuriko Sakamaki, Nobutake Ozeki, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Ichiro Sekiya . Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage. Scientific Reports. 2022.10; 12 (1): 16619. ( PubMed, DOI )

  28. Masaaki Isono, Jun Takeuchi, Ami Maehara, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Yoshinori Asou, Kunikazu Tsuji. Effect of CD44 signal axis in the gain of mesenchymal stem cell surface antigens from synovial fibroblasts in vitro Heliyon. 2022.10; 8 (10): e10739. ( PubMed, DOI )

  29. Ichiro Sekiya, Sho Sasaki, Yugo Miura, Hayato Aoki, Hisako Katano, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Hideyuki Koga, Nobutake Ozeki. Medial tibial osteophyte width strongly reflects medial meniscus extrusion distance and medial joint space width moderately reflects cartilage thickness in knee radiographs. JMRI.(Journal of Magnetic Resonance Imaging). 2022.09; 56 (3): 824-834. ( PubMed, DOI )

  30. Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya. CD34 + THY1 + synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro Arthritis Res Ther. 2022.09; 24 (1): 224. ( PubMed, DOI )

  31. Hiroki Katagiri, Mikio Shioda, Yusuke Nakagawa, Toshiyuki Ohara, Nobutake Ozeki, Tomomasa Nakamura, Ichiro Sekiya, Hideyuki Koga. Risk Factors Affecting Return to Sports and Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy in Active Patients. Orthop J Sports Med. 2022.09; 10 (9): 23259671221118836. ( PubMed, DOI )

  32. Tsukasa Kitahashi, Ryo Kogawa, Kentaro Nakamura, Ichiro Sekiya. Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats. Scientific Reports. 2022.08; 12 (1): 14148. ( PubMed, DOI )

  33. Ichiro Sekiya, Hideyuki Koga, Hisako Katano, Mitsuru Mizuno, Yuji Kohno, Koji Otabe, Nobutake Ozeki. Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: A case report. J Orthop Sci. 2022.07; 27 (4): 821-834. ( PubMed, DOI )

  34. Sekiya Ichiro, Koga Hideyuki, Katano Hisako, Mizuno Mitsuru, Kohno Yuji, Otabe Koji, Ozeki Nobutake. 半月板修復術と滑膜間葉幹細胞移植による内側半月板の変性フラップおよび橈骨断裂治療後のセカンドルック関節鏡検査　症例報告(Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: A case report) Journal of Orthopaedic Science. 2022.07; 27 (4): 821-834. ( ichushi )

  35. Yugo Miura, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya. Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients Stem Cell Research & Therapy. 2022.06; 3 (1): 222. ( PubMed, DOI )

  36. Mituru Mizunoi,Nobutake Ozeki,Ichiro Sekiya. Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis Regenerative Therapy. 2022.06; 17 (21): 81-86. ( PubMed, DOI )

  37. Mituru Mizuno,Takahisa Matsuzaki,Nobutake Ozeki,Hisako Katano,Hideyuki Koga,Takanori Takebe,Hiroshi Yoshikawa,Ichiro Sekiya. Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. Stem Cell Research & Therapy. 2022.05; 13 (1): 177. ( PubMed, DOI )

  38. Hirotaka Nakashima, Soshi Uchida, Akihisa Hatakeyama, Yoichi Murata, Yoshiaki Yamanaka, Manabu Tsukamoto, Ichiro Sekiya, Akinori Sakai. Isolation and Characterization of Synovial Mesenchymal Stem Cells Derived From Patients With Chronic Lateral Ankle Instability: A Comparative Analysis of Synovial Fluid, Adipose Synovium, and Fibrous Synovium of the Ankle Joint. Orthop J Sports Med. 2022.05; 10 (5): 23259671221094615. ( PubMed, DOI )

  39. Guo Tang, Yoshinori Asou, Etsuko Matsumura, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Keiichiro Komori, Ichiro Sekiya, Yoich Ezura, Kunikazu Tsuji. Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway. Heliyon. 2022.05; 8 (5): e09476. ( PubMed, DOI )

  40. Yuji Kohno, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. Journal Orthopaedic Research. 2022.05; 40 (5): 1097-1103. ( PubMed, DOI )

  41. Ozeki N, Koga H, Sekiya I. Degenerative meniscus in knee osteoarthritis: from pathology to treatment. life. 2022.04; 12 (4): 603. ( PubMed, DOI )

  42. Ozeki N, Koga H, Nakamura T, Nakagawa Y, Ohara T, An JS, Sekiya I. Ultrasound-Assisted Arthroscopic All-Inside Repair Technique for Posterior Lateral Meniscus Tear. Arthroscopy techniques. 2022.04; 11 (5): e929-e935. ( PubMed, DOI )

  43. Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis Tissue and Cell. 2022.04; 75 101727. ( PubMed, DOI )

  44. Yugo Miura, Nobutake Ozeki, Hisako Katano, Hayato Aoki, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Difference in the joint space of the medial knee compartment between full extension and Rosenberg weight-bearing radiographs. Eur Radiol. 2022.03; 32 (3): 1429-1437. ( PubMed, DOI )

  45. Hisako Katano, Nobutake Ozeki, Hideyuki Koga, Makoto Tomita, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya. Three-dimensional MRI shows cartilage defect extension with no separation from the meniscus in women in their 70s with knee osteoarthritis. Sci Rep.(Scientific Reports). 2022.03; 12 (1): 4198. ( PubMed, DOI )

  46. Hisako Katano, Nobutake Ozeki, Hideyuki Koga, Kenji Suzuki, Jun Masumoto, Makoto Tomita, Ichiro Sekiya. Interscan measurement error in measurements of the meniscus, including the meniscal roots, by fully automatic three-dimensional MRI analysis. Osteoarthritis Imaging.. 2022.03; 2 (1): ( DOI )

  47. Takashi Hoshino, Yusuke Nakagawa, Kei Inomata, Toshiyuki Ohara, Hiroki Katagiri, Koji Otabe, Kanehiro Hiyama, Kenta Katagiri, Mai Katakura, Hiroko Ueki, Masaya Hayashi, Tsuyoshi Nagase, Ichiro Sekiya, Takashi Ogiuchi, Takeshi Muneta, Hideyuki Koga. Effects of different surgical procedures for meniscus injury on two-year clinical and radiological outcomes after anterior cruciate ligament reconstructions. -TMDU MAKS study. J Orthop Sci. 2022.01; 27 (1): 199-206. ( PubMed, DOI )

  48. Hoshino Takashi, Nakagawa Yusuke, Inomata Kei, Ohara Toshiyuki, Katagiri Hiroki, Otabe Koji, Hiyama Kanehiro, Katagiri Kenta, Katakura Mai, Ueki Hiroko, Hayashi Masaya, Nagase Tsuyoshi, Sekiya Ichiro, Ogiuchi Takashi, Muneta Takeshi, Koga Hideyuki, the Tokyo Medical and Dental University(TMDU) Multicenter Arthroscopic Knee Surgery(MAKS) Group. 半月板損傷に対する異なる術式が前十字靱帯修復後の2年臨床アウトカムとX線学的アウトカムに及ぼす影響　TMDU MAKS試験(Effects of different surgical procedures for meniscus injury on two-year clinical and radiological outcomes after anterior cruciate ligament reconstructions: TMDU MAKS study) Journal of Orthopaedic Science. 2022.01; 27 (1): 199-206. ( ichushi )

  49. Katsuaki Yanagisawa, Toshifumi Watanabe, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Do the distal femur and the proximal tibia have narrower aspect ratios in smaller knees? : A morphological analysis of osteoarthritic knees in the Japanese population using computed tomography. Knee. 2021.12; 33 84-92. ( PubMed, DOI )

  50. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Toshiyuki Ohara, Yuji Kohno, Ichiro Sekiya. Surgical Repair of Symptomatic Wrisberg Variant Discoid Lateral Mensicus with Pull-Out Repair and Capsulodesis. Arthrosc Tech. 2021.12; 11 (1): e61-e68. ( PubMed, DOI )

  51. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya. Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up. Stem Cells Transl Med. 2021.11; 10 (11): 1530-1543. ( PubMed, DOI )

  52. Iwata H, Takada N, Kuroyanagi G, Ikuta K, Usami T, Sekiya I, Murakami H. Effect of hydroxyapatite tubes on the lag screw intraoperative insertion torque for the treatment of intertrochanteric femoral fractures. Injury. 2021.11; 52 (11): 3377-3381. ( PubMed, DOI )

  53. Kentaro Endo, Kiyotaka Horiuchi, Hisako Katano, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Intra-articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats. Stem Cell Rev Rep. 2021.10; 17 (5): 1768-1779. ( PubMed, DOI )

  54. Hisako Katano, Nobutake Ozeki, Yuji Kohno, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Tetsuya Jinno, Ichiro Sekiya. Trends in arthroplasty in Japan by a complete survey, 2014-2017. J Orthop Sci. 2021.09; 26 (5): 812-822. ( PubMed, DOI )

  55. Katano Hisako, Ozeki Nobutake, Kohno Yuji, Nakagawa Yusuke, Koga Hideyuki, Watanabe Toshifumi, Jinno Tetsuya, Sekiya Ichiro. 全数調査に基づいた日本での人工関節置換術の傾向　2014年～2017年(Trends in arthroplasty in Japan by a complete survey, 2014-2017) Journal of Orthopaedic Science. 2021.09; 26 (5): 812-822. ( ichushi )

  56. Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells. Stem Cells Int. 2021.08; eCollection 2021:9239728. ( PubMed, DOI )

  57. Takashi Hoshino, Toshifumi Watanabe, Yusuke Nakagawa, Hiroki Katagiri, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kono, Ichiro Sekiya, Hideyuki Koga. Clinical outcomes of two-stage revision total knee arthroplasty in infected cases with antibiotic-loaded cement spacers produced using a handmade silicone mold. Knee Surg Relat Res. 2021.08; 33 (1): 27. ( PubMed, DOI )

  58. Toshifumi Watanabe, Kazuyoshi Gamada, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Consistent femoral external rotation during weight-bearing knee flexion is associated with better patient-reported pain and mediolateral balance after total knee arthroplasty. Clin Biomech (Bristol, Avon). 2021.08; 88 105438. ( PubMed, DOI )

  59. Hiroki Katagiri, Kaori Nakamura, Takeshi Muneta, Toshifumi Watanabe, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. Inflammatory and healing environment in synovial fluid after anterior cruciate ligament reconstruction: Granulocytes and endogenous opioids as new targets of postoperative pain. Biochem Biophys Rep. 2021.07; 26 100981. ( PubMed, DOI )

  60. Hiroko Ueki, Hiroki Katagiri, Kunikazu Tsuji, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model. J Orthop Sci. 2021.07; 26 (4): 690-697. ( PubMed, DOI )

  61. Ichiro Sekiya, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Jun Masumoto, Makoto Tomita, Nobutake Ozeki. Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees. Sci Rep. 2021.07; 11 (1): 13832. ( PubMed, DOI )

  62. Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya, Hiroki Katagiri. Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci. Stem Cell Res Ther. 2021.07; 12 (1): 414. ( PubMed, DOI )

  63. Nobutake Ozeki, Yusuke Nakagawa, Mitsuru Mizuno, Yuji Kohno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. Ultrasound-Guided Harvesting of Synovium for Regenerative Medicine of Cartilage and Meniscus Using Synovial Mesenchymal Stem Cells. Arthrosc Tech. 2021.07; 10 (7): e1723-e1727. ( PubMed, DOI )

  64. Ichiro Sekiya, Yuji Kohno, Akinobu Hyodo, Hisako Katano, Keiichiro Komori, Hideyuki Koga, Makoto Tomita, Kenji Suzuki, Jun Masumoto, Nobutake Ozeki. Interscan measurement error of knee cartilage thickness and projected cartilage area ratio at 9 regions and 45 subregions by fully automatic three-dimensional MRI analysis. Eur J Radiol. 2021.06; 139 109700. ( PubMed, DOI )

  65. Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats. Sci Rep. 2021.05; 11 (1): 9683. ( PubMed, DOI )

  66. J-S An, K Tsuji, H Onuma, N Araya, M Isono, T Hoshino, K Inomata, J Hino, M Miyazato, H Hosoda, K Kangawa, Y Nakagawa, H Katagiri, K Miyatake, I Sekiya, T Muneta, H Koga. Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. Osteoarthritis Cartilage. 2021.03; 29 (3): 380-388. ( PubMed, DOI )

  67. Ichiro Sekiya, Hisako Katano, Nobutake Ozeki. Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis. Int J Mol Sci. 2021.03; 22 (6): 2838. ( PubMed, DOI )

  68. Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya. Arthroscopic Centralization Using Knotless Anchors for Extruded Medial Meniscus. Arthrosc Tech. 2021.03; 10 (3): e639-e645. ( PubMed, DOI )

  69. Toshifumi Watanabe, Kazuyoshi Gamada, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Characteristic kinematics of floor-sitting activities after posterior-stabilized total knee arthroplasty determined using model-based shape-matching techniques. Knee. 2021.03; 29 571-579. ( PubMed, DOI )

  70. Weiding Cui, Yusuke Nakagawa, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Takashi Hoshino, Aritoshi Yoshihara, Ichiro Sekiya, Hideyuki Koga. Knee laxity, lateral meniscus tear and distal femur morphology influence pivot shift test grade in ACL injury patients. Knee Surg Sports Traumatol Arthrosc. 2021.02; 29 (2): 633-640. ( PubMed, DOI )

  71. Nobutake Ozeki, Yuji Kohno, Yoshihisa Kushida, Naoto Watanabe, Mitsuru Mizuno, Hisako Katano, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model. J. Orthop. Res.. 2021.01; 39 (1): 177-183. ( PubMed, DOI )

  72. Kiyotaka Horiuchi, Mitsuru Mizuno, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting. J Med Dent Sci.. 2021.01; 68 17-26. ( DOI )

  73. Horiuchi Kiyotaka, Mizuno Mitsuru, Katano Hisako, Endo Kentaro, Ozeki Nobutake, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro. 臨床実地にて初代滑膜間葉系幹細胞の数が最大となるような最適な初期細胞密度(Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting) Journal of Medical and Dental Sciences. 2021; 68 17-26. ( ichushi )

  74. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Koichiro Kishima, Yoshio Soma, Ichiro Sekiya. Two- and three-dimensional optical coherence tomography to differentiate degenerative changes in a rat meniscectomy model. J Orthop Res. 2020.12; 38 (12): 2592-2600. ( PubMed, DOI )

  75. Watanabe N, Endo K, Komori K, Ozeki N, Mizuno M, Katano H, Kohno Y, Tsuji K, Koga H, Sekiya I. Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF. Stem cell reviews and reports. 2020.12; 16 (6): 1305-1315. ( PubMed, DOI )

  76. Yoshie Seki, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga. Investigation of association between the preoperative intra-articular anesthetic test and persistent pain after total knee arthroplasty. J Orthop Sci. 2020.11; 25 (6): 1055-1060. ( PubMed, DOI )

  77. Hayato Aoki, Nobutake Ozeki, Hisako Katano, Akinobu Hyodo, Yugo Miura, Junpei Matsuda, Kimiko Takanashi, Kenji Suzuki, Jun Masumoto, Noriya Okanouchi, Takeo Fujiwara, Ichiro Sekiya. Relationship between medial meniscus extrusion and cartilage measurements in the knee by fully automatic three-dimensional MRI analysis. BMC Musculoskelet Disord. 2020.11; 21 (1): 742. ( PubMed, DOI )

  78. Hideyuki Koga, Tomomasa Nakamura, Hiroki Katagiri, Yusuke Nakagawa, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya. Two-Year Outcomes After Meniscoplasty by Capsular Advancement With the Application of Arthroscopic Centralization Technique for Lateral Compartment Knee Osteoarthritis. Am J Sports Med. 2020.11; 48 (13): 3154-3162. ( PubMed, DOI )

  79. Seki Yoshie, Katagiri Hiroki, Otabe Koji, Nakagawa Yusuke, Miyatake Kazumasa, Sekiya Ichiro, Koga Hideyuki. 人工関節全置換術前の関節内麻酔テストと術後の持続性疼痛の関連の検討(Investigation of association between the preoperative intra-articular anesthetic test and persistent pain after total knee arthroplasty) Journal of Orthopaedic Science. 2020.11; 25 (6): 1055-1060. ( ichushi )

  80. Yoichi Murata, Soshi Uchida, Hajime Utsunomiya, Akihisa Hatakeyama, Hirotaka Nakashima, Toshiharu Mori, Yoshiaki Yamanaka, Manabu Tsukamoto, Ichiro Sekiya, Johnny Huard, Marc J Philippon, Akinori Sakai. Differentiation Potential of Synovial Mesenchymal Stem Cells Isolated From Hip Joints Affected by Femoroacetabular Impingement Syndrome Versus Osteoarthritis. Arthroscopy. 2020.08; 36 (8): 2122-2133. ( PubMed, DOI )

  81. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Ayako Tsuji, Naomi Kojima, Ken Watanabe, Norio Shimizu, Tomohiro Morio, Ichiro Sekiya. The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution. PLoS ONE. 2020.08; 15 (8): e0236600. ( PubMed, DOI )

  82. So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus. Lab. Invest.. 2020.07; 100 (7): 916-927. ( PubMed, DOI )

  83. Naoko Araya, Kazumasa Miyatake, Kunikazu Tsuji, Hiroki Katagiri, Yusuke Nakagawa, Takashi Hoshino, Hiroaki Onuma, Saisei An, Hirofumi Nishio, Yoshitomo Saita, Ichiro Sekiya, Hideyuki Koga. Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model. Am J Sports Med. 2020.07; 48 (8): 2004-2012. ( PubMed, DOI )

  84. Hiroaki Onuma, Kunikazu Tsuji, Takashi Hoshino, Kei Inomata, Mio Udo, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain. J. Orthop. Res.. 2020.06; 38 (6): 1296-1306. ( PubMed, DOI )

  85. Toshifumi Watanabe, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Takeshi Muneta, Ichiro Sekiya, Tetsuya Jinno.. Coronal and sagittal laxity affects clinical outcomes in posterior-stabilized total knee arthroplasty: assessment of well-functioning knees. Knee Surg Sports Traumatol Arthrosc. . 2020.05; 28 (5): 1400-1409. ( PubMed, DOI )

  86. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. The effect of a centralization procedure for extruded lateral meniscus on load distribution in porcine knee joints at different flexion angles. BMC Musculoskelet Disord. 2020.04; 21 (1): 205. ( PubMed, DOI )

  87. Naoko Araya, Hiroki Katagiri , Yusuke Nakagawa, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya, Hideyuki Koga.. Predictors of residual mechanical symptoms after meniscus surgery: data from the maks group Osteoarthritis and Cartilage. 2020.04; 28 (1): S221-S223.

  88. Masaki Amemiya, Kunikazu Tsuji, Hiroki Katagiri, Kazumasa Miyatake, Yusuke Nakagawa, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Synovial fluid-derived mesenchymal cells have non-inferior chondrogenic potential and can be utilized for regenerative therapy as substitute for synovium-derived cells. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 465-472. ( PubMed, DOI )

  89. Hiroki Katagiri, Kazumasa Miyatake, Toshifumi Watanabe, Masafumi Horie, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Validity of intraoperative observation of graft length change pattern for medial patellofemoral ligament reconstruction. J Orthop. 2020.03; 21 131-136. ( PubMed, DOI )

  90. Kaori Nakamura, Tomomasa Nakamura, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Masaki Amemiya, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Anatomic femoral tunnel placement is difficult by the transtibial technique: comparison of three different femoral tunnel drilling techniques in double-bundle anterior cruciate ligament reconstructions. Knee Surg Sports Traumatol Arthrosc. 2020.02; 28 (2): 584-593. ( PubMed, DOI )

  91. Nobutake Ozeki, Hideyuki Koga, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Tomoyuki Saito, Takeshi Muneta, Ichiro Sekiya. Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model. J Orthop Sci.. 2020.01; 25 (1): 161-166. ( PubMed, DOI )

  92. Mai Katakura, Kaori Nakamura, Toshifumi Watanabe, Masafumi Horie, Tomomasa Nakamura, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Toshiyuki Ohara, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Risk factors for residual anterolateral rotational instability after double bundle anterior cruciate ligament reconstruction: Evaluation by quantitative assessment of the pivot shift phenomenon using triaxial accelerometer. Knee. 2020.01; 27 (1): 95-101. ( PubMed, DOI )

  93. Hajime Utsunomiya, Ichiro Sekiya, Soshi Uchida.. Editorial Commentary:Are We Ready to Apply Stem Cell Therapy in Rotator Curr Tear Surgery? Arthroscopy.. 2020.01; 36 (1): 86-87. ( PubMed, DOI )

  94. Ozeki Nobutake, Koga Hideyuki, Matsuda Junpei, Kohno Yuji, Mizuno Mitsuru, Katano Hisako, Tsuji Kunikazu, Saito Tomoyuki, Muneta Takeshi, Sekiya Ichiro. ブタモデルの後根欠損を伴う逸脱外側半月に対する中心化の生体力学的解析(Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model) Journal of Orthopaedic Science. 2020.01; 25 (1): 161-166. ( ichushi )

  95. Hiroki Katagiri, Kazumasa Miyatake, Yusuke Nakagawa, Koji Otabe, Toshiyuki Ohara, Mikio Shioda, Ichiro Sekiya, Hideyuki Koga. The effect of a longitudinal tear of the medial meniscus on medial meniscal extrusion in anterior cruciate ligament injury patients. Knee. 2019.12; 26 (6): 1292-1298. ( PubMed, DOI )

  96. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Time-lapse image analysis for whole colony growth curves and daily distribution of the cell number per colony during the expansion of mesenchymal stem cells. Sci Rep. 2019.11; 9 (1): 16835. ( PubMed, DOI )

  97. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Comparison of High-Hydrostatic-Pressure Decellularized Versus Freeze-Thawed Porcine Menisci. J. Orthop. Res.. 2019.11; 37 (11): 2466-2475. ( PubMed, DOI )

  98. Ichiro Sekiya, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Masafumi Horie, Yuji Kohno, Kenta Katagiri, Naoto Watanabe, Takeshi Muneta. Additional Use of Synovial Mesenchymal Stem Cell Transplantation Following Surgical Repair of a Complex Degenerative Tear of the Medial Meniscus of the Knee: A Case Report. Cell Transplant. 2019.11; 28 (11): 1445-1454. ( PubMed, DOI )

  99. Miwa S, Okamoto H, Yamada S, Kawaguchi Y, Endo K, Aiba H, Hayashi K, Kimura H, Sekiya I, Otsuka T, Tsuchiya H. Distribution of Solitary and Multiple Enchondromas of the Hand. In vivo (Athens, Greece). 2019.11; 33 (6): 2235-2240. ( PubMed, DOI )

  100. Akinobu Hyodo, Nobutake Ozeki, Yuji Kohno, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Makoto Tomita, Yusuke Nakagawa, Hideyuki Koga, Shinji Kiuchi, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya. Projected Cartilage Area Ratio Determined by 3-Dimensional MRI Analysis: Validation of a Novel Technique to Evaluate Articular Cartilage. JB JS Open Access. 2019.10; 4 (4): e0010. ( PubMed, DOI )

  101. Yusuke Nakagawa, Toshifumi Watanabe, Yusuke Amano, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Mai Katakura, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Benefit of subcutaneous patient controlled analgesia after total knee arthroplasty. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2019.10; 18 18-22. ( PubMed, DOI )

  102. Shimpei Kondo, Yusuke Nakagawa, Mitsuru Mizuno, Kenta Katagiri, Kunikazu Tsuji, Shinji Kiuchi, Hideo Ono, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya. Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs. Am J Sports Med. 2019.08; 47 (10): 2338-2347. ( PubMed, DOI )

  103. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Cryopreservation in 95% serum with 5% DMSO maintains colony formation and chondrogenic abilities in human synovial mesenchymal stem cells. BMC Musculoskelet Disord. 2019.07; 20 (1): 316. ( PubMed, DOI )

  104. Hiroko Ueki, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Takashi Hoshino, Ichiro Sekiya, Hideyuki Koga. Contribution of Additional Anterolateral Structure Augmentation to Controlling Pivot Shift in Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2019.07; 47 (9): 2093-2101. ( PubMed, DOI )

  105. Naritomi Mana, Mizuno Mitsuru, Katano Hisako, Ozeki Nobutake, Otabe Koji, Komori Keiichiro, Fujii Shizuka, Ichinose Shizuko, Tsuji Kunikazu, Koga Hideyuki, Muneta Takeshi, Sekiya Ichiro.. Petaloid recombinant peptide enhances in vitro cartilage formation by synovial mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2019.06; 37 (6): 1350-1357. ( PubMed, DOI )

  106. Kaori Nakamura, Kunikazu Tsuji, Mitsuru Mizuno, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Initial cell plating density affects properties of human primary synovial mesenchymal stem cells. J. Orthop. Res.. 2019.06; 37 (6): 1358-1367.

  107. Akari Sasaki, Mitsuru Mizuno, Manabu Mochizuki, Ichiro Sekiya. Mesenchymal stem cells for cartilage regeneration in dogs. World J Stem Cells. 2019.05; 11 (5): 254-269. ( PubMed, DOI )

  108. Sonoko Noda, Nobuyuki Kawashima, Mioko Yamamoto, Kentaro Hashimoto, Keisuke Nara, Ichiro Sekiya, Takashi Okiji. Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation. Sci Rep. 2019.04; 9 (1): 5430. ( PubMed, DOI )

  109. Watanabe Toshifumi, Aoki Akino, Hoshi Kenji, Muneta Takeshi, Sekiya Ichiro, Koga Hideyuki. Anterior Tibial Post Impingement during Stair Climbing: A Kinematic Analysis and Clinical Outcome J Arthroplasty. 2019.02; 34 (2): 379-384.

  110. Tomomasa Nakamura, Hideyuki Koga, Koji Otabe, Masafumi Horie, Toshifumi Watanabe, Kazuyoshi Yagishita, Ichiro Sekiya, Takeshi Muneta. Comparison of three approaches for femoral tunnel during double-bundle anterior cruciate ligament reconstruction: A case controlled study. J Orthop Sci. 2019.01; 24 (1): 147-152.

  111. Inomata Kei, Tsuji Kunilazu, Onuma Hroaki, Hoshino Takashi, Udo Mio, Akiyama Masako, Nakagawa Yusuke, Katagiri Hiroki, Miyatake Kazumasa, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint BMC Musculoskelet Disord. 2019.01; 20 (8):

  112. Mai Katakura, Masafumi Horie, Toshifumi Watanabe, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Kaori Nakamura, Kenta Katagiri, Hiroko Ueki, Stefano Zaffagnini, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Effect of meniscus repair on pivot-shift during anterior cruciate ligament reconstruction: Objective evaluation using triaxial accelerometer. Knee. 2019.01; 26 (1): 124-131. ( PubMed, DOI )

  113. Nakamura Tomomasa, Koga Hideyuki, Otabe Koji, Horie Masafumi, Watanabe Toshifumi, Yagishita Kazuyoshi, Sekiya Ichiro, Muneta Takeshi. 二重束前十字靱帯再建中の大腿骨孔作成に用いられる3種類のアプローチの比較　症例対照研究(Comparison of three approaches for femoral tunnel during double-bundle anterior cruciate ligament reconstruction: A case controlled study) Journal of Orthopaedic Science. 2019.01; 24 (1): 147-152. ( ichushi )

  114. Hiroko Ueki, Yusuke Nakagawa, Toshiyuki Ohara, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Kenta Katagiri, Kanehiro Hiyama, Mai Katakura, Takashi Hoshino, Kei Inomata, Naoko Araya, Ichiro Sekiya. Risk factors for residual pivot shift after anterior cruciate ligament reconstruction: data from the MAKS group. Knee Surg Sports Traumatol Arthrosc. 2018.12; 26 (12): 3724-3730. ( PubMed, DOI )

  115. Yoichi Murata, Soshi Uchida, Hajime Utsunomiya, Akihisa Hatakeyama, Hirotaka Nakashima, Angela Chang, Ichiro Sekiya, Akinori Sakai. Synovial mesenchymal stem cells derived from the cotyloid fossa synovium have higher self-renewal and differentiation potential than those from the paralabral synovium in the hip joint. American Journal of Sports Medicine. 2018.10; 46 (12): 2942-2953. ( PubMed, DOI )

  116. Akari Sasaki, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya. Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow. PLoS ONE. 2018.08; 13 (8): e0202922. ( PubMed, DOI )

  117. Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe, Ichiro Sekiya, Hideyuki Koga, Takeshi Muneta. Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone. BMC Musculoskelet Disord. 2018.08; 19 (1): 291. ( PubMed, DOI )

  118. Katano H, Koga H, Ozeki N, Otabe K, Mizuno M, Tomita M, Muneta T, Sekiya I.. Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016. PLoS ONE. 2018.07; 23 (4): 676-681. ( PubMed )

  119. Katano Hisako, Koga Hideyuki, Ozeki Nobutake, Otabe Koji, Mizuno Mitsuru, Tomita Makoto, Muneta Takeshi, Sekiya Ichiro. 日本における2011～2016年の分離半月板修復術と半月板切除術の傾向(Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016) Journal of Orthopaedic Science. 2018.07; 23 (4): 676-681. ( ichushi )

  120. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage Regenerative Medicine. 2018.06; 8 20-28. ( PubMed, DOI )

  121. Mari Uomizu, Takeshi Muneta, Miyoko Ojima, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB/Akt pathway. J Med Dent Sci. 2018.06; 65 (2): 73-82.

  122. Mindae Kim, Watanabe Toshifumi, Muneta Takeshi, Ohara Toshiyuki, Sekiya Ichiro, Koga Hideyuki. Bi-Surfaceタイプ3を用いた人工膝関節置換術の施行後において冠状面で評価した不安定性　平均して10年間にわたる経過観察研究(Coronal Instability after Total Knee Arthroplasty using Bi-Surface type 3: An Averaged 10 Year Follow-up Study) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 51-58. ( ichushi )

  123. Uomizu Mari, Muneta Takeshi, Ojima Miyoko, Sekiya Ichiro, Koga Hideyuki, Tsuji Kunikazu. PDGFが誘導する滑膜間葉系幹細胞の増殖と分化はPI3K-PKB/Akt経路によって媒介されている(PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB/Akt pathway) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 73-82. ( ichushi )

  124. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. 前十字靱帯に由来する間葉系間質細胞は靱帯へと分化する傾向を有している(Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage) Regenerative Therapy. 2018.06; 8 20-28. ( ichushi )

  125. Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta, Ichiro Sekiya. Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions. Stem Cell Res Ther. 2018.05; 9 (1): 123. ( PubMed, DOI )

  126. Takao Minami, Takeshi Muneta, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Hideyuki Koga. Lateral meniscus posterior root tear contributes to anterolateral rotational instability and meniscus extrusion in anterior cruciate ligament-injured patients. Knee Surg Sports Traumatol Arthrosc. 2018.04; 26 (4): 1174-1181. ( PubMed, DOI )

  127. Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow. Stem Cell Res Ther. 2018.03; 9 (1): 80. ( PubMed, DOI )

  128. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Ichiro Sekiya. Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis. BMC Musculoskelet Disord. 2018.03; 19 (1): 78. ( PubMed, DOI )

  129. Kanehiro Hiyama, Yusuke Nakagawa, Toshiyuki Ohara, Takeshi Muneta, Toshifumi Watanabe, Masafumi Horie, Koji Otabe, Hiroki Katagiri, Kenta Katagiri, Mai Katakura, Takashi Hoshino, Hiroko Ueki, Kei Inomata, Naoko Araya, Ichiro Sekiya, Hideyuki Koga. Anterior cruciate ligament injuries result in a larger functional deficit in fighting sport athletes: comparison of functional status among different sport types. Journal of ISAKOS. 2018.03; (3): 128-133.

  130. Minami Takao, Koga Hideyuki, Sekiya Ichiro, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Muneta Takeshi. 円板状外側半月板のある膝に対して大腿骨外側顆の骨形態学的特徴に応じて後方から挿入された前十字靱帯(Posteriorly inserted anterior cruciate ligament in knees with discoid lateral meniscus corresponding to bony morphological characteristics of femoral lateral condyle) Journal of Orthopaedic Science. 2018.03; 23 (2): 350-355. ( ichushi )

  131. Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa. Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro. Stem Cell Reports. 2018.02; 10 (2): 568-582. ( PubMed, DOI )

  132. F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander. Toward classification criteria for early osteoarthritis of the knee. Semin. Arthritis Rheum.. 2018.02; 47 (4): 457-463. ( PubMed, DOI )

  133. Takuya Oyaizu, Mitsuhiro Enomoto, Naoki Yamamoto, Kunikazu Tsuji, Masaki Horie, Takeshi Muneta, Ichiro Sekiya, Atsushi Okawa, Kazuyoshi Yagishita. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018.01; 8 (1): 1288. ( PubMed, DOI )

  134. Ishii Kana, Suzuki Nobuharu, Mabuchi Yo, Sekiya Ichiro, Akazawa Chihiro. Technical advantage of recombinant collagenase for isolation of muscle stem cells REGENERATIVE THERAPY. 2017.12; 7 1-7. ( PubMed, DOI )

  135. Ishii Kana, Suzuki Nobuharu, Mabuchi Yo, Sekiya Ichiro, Akazawa Chihiro. Technical advantage of recombinant collagenase for isolation of muscle stem cells(和訳中) Regenerative Therapy. 2017.12; 7 1-7. ( ichushi )

  136. Sekiya I, Kobayashi M, Okamoto H, Otsuka T. Progress and Role of Finger Joint Arthroscopy. Hand clinics. 2017.11; 33 (4): 819-829. ( PubMed, DOI )

  137. Ichiro Sekiya, Darwin J.Prockop.. Beginning of an Unresolved Debate:Should Mesenchymal Stem Cells Be Expanded at Low Density to Preserve Early Progenitors? STEM CELLS 35Anniversary. 2017.09; 1 36-37.

  138. Nakagawa Y, Muneta T, Watanabe T, Horie M, Nakamura T, Otabe K, Katakura M, Sumi Y, Sekiya I, Koga H. Arthroscopic centralization achieved good clinical improvements and radiographic outcomes in a rugby player with osteoarthritis after subtotal lateral meniscectomy: A case report. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2017.09; 25 (3): 537-543. ( PubMed, DOI )

  139. Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Takeshi Muneta. Evaluation of pivot shift phenomenon while awake and under anaesthesia by different manoeuvres using triaxial accelerometer. Knee Surg Sports Traumatol Arthrosc. 2017.08; 25 (8): 2377-2383. ( PubMed, DOI )

  140. Kei Inomata, Ichiro Sekiya, Koji Otabe, Tomomasa Nakamura, Masafumi Horie, Hideyuki Koga, Toshifumi Watanabe, Takeshi Muneta. Acute arterial occlusion after total knee arthroplasty: a case report. Clin Case Rep. 2017.08; 5 (8): 1376-1380. ( PubMed, DOI )

  141. Hideyuki Koga, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Ichiro Sekiya, Takeshi Muneta. Augmentation of the pullout repair of a medialmeniscus posterior root tear by arthroscopic centralization Arthroscopy techniques. 2017.08; 6 (4): 1335-1339. ( PubMed, DOI )

  142. Carballo CB, Nakagawa Y, Sekiya I, Rodeo SA.. Basic Science of Articular Cartilage. Clin Sports Med.. 2017.07; 36 (3): 413-425.

  143. Eriko Grace Suto, Yo Mabuchi, Nobuharu Suzuki, Koji Suzuki, Yusuke Ogata, Miyu Taguchi, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73(+) population and exhibit efficacy after transplantation. Sci Rep. 2017.07; 7 (1): 4838. ( PubMed, DOI )

  144. Toshifumi Watanabe, Hideyuki Koga, Masafumi Horie, Hiroki Katagiri, Ichiro Sekiya, Takeshi Muneta. Post-Cam Design and Contact Stress on Tibial Posts in Posterior-Stabilized Total Knee Prostheses: Comparison Between a Rounded and a Squared Design. J Arthroplasty. 2017.07; 32 (12): 3757-3762. ( PubMed, DOI )

  145. Carballo Camila B., Nakagawa Yusuke, Sekiya Ichiro, Rodeo Scott A.. Basic Science of Articular Cartilage CLINICS IN SPORTS MEDICINE. 2017.07; 36 (3): 413-+. ( PubMed, DOI )

  146. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation. Stem Cell Res Ther. 2017.06; 8 (1): 144. ( PubMed, DOI )

  147. Kunikazu Tsuji, Miyoko Ojima, Koji Otabe, Masafumi Horie, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta. Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells. Cell Transplant. 2017.06; 26 (6): 1089-1102. ( PubMed, DOI )

  148. Sekiya Ichiro. 動物モデルから臨床応用へ 膝関節の再生医療　疾患モデルから臨床治療へ(From Animal Models to Clinics Regenerative medicine for the knee joint: from disease models to clinical treatments) Experimental Animals. 2017.06; 66 (Suppl.): S15. ( ichushi )

  149. Nobutake Ozeki, Takeshi Muneta, Kenichi Kawabata, Hideyuki Koga, Yusuke Nakagawa, Ryusuke Saito, Mio Udo, Katsuaki Yanagisawa, Toshiyuki Ohara, Tomoyuki Mochizuki, Kunikazu Tsuji, Tomoyuki Saito, Ichiro Sekiya. Centralization of extruded medial meniscus delays cartilage degeneration in rats. J Orthop Sci. 2017.05; 22 (3): 542-548. ( PubMed, DOI )

  150. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya. Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients. Stem Cell Res Ther. 2017.05; 8 (1): 115. ( PubMed, DOI )

  151. Mikio Shioda, Takeshi Muneta, Kunikazu Tsuji, Mitsuru Mizuno, Keiichiro Komori, Hideyuki Koga, Ichiro Sekiya. TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential. PLoS ONE. 2017.05; 12 (5): e0177771. ( PubMed, DOI )

  152. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Sekiya Ichiro, Muneta Takeshi. すべてが分かる半月板損傷の治療 半月板突出の関節鏡下centralization法と膝関節症における膝関節機能回復のための本手術法の応用(Arthroscopic Centralization of an Extruded Meniscus and Its Application to Knee Osteoarthritis to Restore Knee Function) JOSKAS. 2017.05; 42 (4): 526. ( ichushi )

  153. Ozeki Nobutake, Muneta Takeshi, Kawabata Kenichi, Koga Hideyuki, Nakagawa Yusuke, Saito Ryusuke, Udo Mio, Yanagisawa Katsuaki, Ohara Toshiyuki, Mochizuki Tomoyuki, Tsuji Kunikazu, Saito Tomoyuki, Sekiya Ichiro. ラットの内側半月板逸脱に対するcentralizationにより軟骨変性が遅延する(Centralization of extruded medial meniscus delays cartilage degeneration in rats) Journal of Orthopaedic Science. 2017.05; 22 (3): 542-548. ( ichushi )

  154. Katagiri Kenta, Yu Matsukura, Takeshi Muneta, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya.. Fibrous synovium releases higher numbers of mesenchymal stem cells than adipose synovium in a suspended synovium culture model. Arthroscopy. 2017.04; 33 (4): 800-810. ( PubMed, DOI )

  155. Jae-Sung An, Takeshi Muneta, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Hideyuki Koga. Osteochondral lesion of lateral tibial plateau with extrusion of lateral meniscus treated with retrograde osteochondral autograft transplantation and arthroscopic centralisation. AP-SMART. 2017.04; 8 18-23. ( PubMed, DOI )

  156. Ojima M., Tsuji K., Otabe K., Horie M., Koga H., Sekiya I., Muneta T.. ANALYSES OF BIOLOGICALLY ACTIVE SUBSTANCES IN SYNOVIAL FLUID WHICH SUPPORT PROLIFERATION OF SYNOVIAL MESENCHYMAL STEM CELLS OSTEOARTHRITIS AND CARTILAGE. 2017.04; 25 S425-S426.

  157. Watanabe Toshifumi, Muneta Takeshi, Koga Hideyuki, Horie Masafumi, Otabe Koji, Ohara Toshiyuki, Nakamura Kaori, Katakura Mai, Okawa Atsushi, Sekiya Ichiro. 人工膝関節全置換術における脛骨ポストに対するカム後部設計と接触ストレス　円形と角型デザインの比較(Post-cam design and contact stress on tibial posts in total knee prostheses: Comparison between a rounded and a squared design) 日本整形外科学会雑誌. 2017.03; 91 (2): S453. ( ichushi )

  158. Yuuki Arata, Muneta Takeshi, Ohara Toshiyuki, Sekiya Ichiro, Koga Hideyuki. 前十字靱帯損傷膝における外側/内側膝不安定性とその関連要因との相関(Associated lateral/medial knee instability and its relevant factors in anterior cruciate ligament-injured knees) Journal of Orthopaedic Science. 2017.03; 22 (2): 300-305. ( ichushi )

  159. Yuuki A, Muneta T, Ohara T, Sekiya I, Koga H.. Associated lateral/medial knee instability and its relevant factors in anterior cruciate ligament-injured knees. J Orthop Sci. 2017.03; 22 (2): 300-305. ( PubMed, DOI )

  160. Matsumura E, Tsuji K, Komori K, Koga H, Sekiya I, Muneta T.. Pretreatment of IL-1β enhances proliferation and chondrogenic potential of synovium-derived mesenchymal stem cells. Cytotherapy. 2017.02; 19 (2): 181-193. ( PubMed, DOI )

  161. Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai. Isolation and Characterization of Synovial Mesenchymal Stem Cell Derived from Hip Joints: A Comparative Analysis with a Matched Control Knee Group. Stem Cells Int. 2017.01; 2017 9312329. ( PubMed, DOI )

  162. Saito R, Muneta T, Ozeki N, Nakagawa Y, Udo M, Yanagisawa K, Tsuji K, Tomita M, Koga H, Sekiya I.. Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats. BMC Musculoskelet Disord. 2017.01; 18 (1): 36. ( PubMed, DOI )

  163. Inoue M, Muneta T, Ojima M, Nakamura K, Koga H, Sekiya I, Okazaki M, Tsuji K.. Inflammatory cytokine levels in synovial fluid 3, 4 days postoperatively and its correlation with early-phase functional recovery after anterior cruciate ligament reconstruction: a cohort study. J Exp Orthop.. 2016.12; 3 (1): 30. ( PubMed )

  164. Shirasawa S, Koga H, Horie M, Nakamura T, Watanabe T, Sekiya I, Muneta T.. Forced knee extension test is a manual test that correlates with the unstable feelings of patients with ACL injury before and after reconstruction. Knee. 2016.12; 23 (6): 1159-1163. ( PubMed )

  165. Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Takeshi Muneta. Dynamic Evaluation of Pivot-Shift Phenomenon in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Triaxial Accelerometer. Arthroscopy. 2016.12; 32 (12): 2532-2538. ( PubMed, DOI )

  166. Toshiyuki Ohara, Takeshi Muneta, Yusuke Nakagawa, Yu Matsukura, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. <Original Article>Hypoxia enhances proliferation through increase of colony formation rate with chondrogenic potential in primary synovial mesenchymal stem cells. J. Med. Dent. Sci.. 2016.12; 63 (4): 61-70. ( PubMed, DOI )

  167. Kanehiro Hiyama, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya, Kunikazu Tsuji. Meniscal regeneration after resection of the anterior half of the medial meniscus in mice. J. Orthop. Res.. 2016.11; 35 (9): 1958-1965. ( PubMed, DOI )

  168. Watanabe T, Muneta T, Koga H, Horie M, Nakamura T, Otabe K, Nakagawa Y, Katakura M, Sekiya I.. In-vivo kinematics of high-flex posterior-stabilized total knee prosthesis designed for Asian populations. Int Orthop. 2016.11; 40 (11): 2295-2302. ( PubMed, DOI )

  169. Koga H, Muneta T, Watanabe T, Mochizuki T, Horie M, Nakamura T, Otabe K, Nakagawa Y, Sekiya I.. Two-Year Outcomes After Arthroscopic Lateral Meniscus Centralization Arthroscopy. 2016.10; 32 (10): 2000-2008.

  170. Takeshi Muneta, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Toshifumi Watanabe, Ichiro Sekiya. Behind-remnant arthroscopic observation and scoring of femoral attachment of injured anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc. 2016.09; 24 (9): 2906-2914. ( PubMed, DOI )

  171. Hiroki Katagiri, Kaori Nakamura, Toshifumi Watanabe, Hideyuki Koga, Kazuyoshi Yagishita, Ichiro Sekiya, Takeshi Muneta. Increase of patellofemoral height has decreased maximum knee flexion after total knee arthroplasty of posterior cruciate-substituting prosthesis in a clinical series. J Orthop Sci. 2016.07; 21 (4): 458-462. ( PubMed, DOI )

  172. Mio Udo, Takeshi Muneta, Kunikazu Tsuji, Nobutake Ozeki, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Katsuaki Yanagisawa, Hideyuki Koga, Ichiro Sekiya. Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems. Osteoarthr. Cartil.. 2016.07; 24 (7): 1284-1291. ( PubMed, DOI )

  173. N Ozeki, T Muneta, H Koga, Y Nakagawa, M Mizuno, K Tsuji, Y Mabuchi, C Akazawa, E Kobayashi, K Matsumoto, K Futamura, T Saito, I Sekiya. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats. Osteoarthr. Cartil.. 2016.06; 24 (6): 1061-1070. ( PubMed, DOI )

  174. Mai Katakura, Hideyuki Koga, Kaori Nakamura, Ichiro Sekiya, Takeshi Muneta. Effects of different femoral tunnel positions on tension changes in anterolateral ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2016.05; 25 (4): 1272-1278. ( PubMed, DOI )

  175. Kazumasa Miyatake, Takeshi Muneta, Miyoko Ojima, Jun Yamada, Yu Matsukura, Kahaer Abula, Ichiro Sekiya, Kunikazu Tsuji. Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration. BMC Musculoskelet Disord. 2016.05; 17 (1): 238. ( PubMed, DOI )

  176. Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Weekly injections of Hylan G-F 20 delay cartilage degeneration in partial meniscectomized rat knees. BMC Musculoskelet Disord. 2016.04; 17 (1): 188. ( PubMed, DOI )

  177. Toshifumi Watanabe, Takeshi Muneta, Kazuyoshi Yagishita, Kenji Hara, Hideyuki Koga, Ichiro Sekiya. Closed Suction Drainage Is Not Necessary for Total Knee Arthroplasty: A Prospective Study on Simultaneous Bilateral Surgeries of a Mean Follow-Up of 5.5 Years. J Arthroplasty. 2016.03; 31 (3): 641-645. ( PubMed, DOI )

  178. Shimpei Kondo, Takeshi Muneta, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Kunikazu Tsuji, Shinichi Sotome, Atsushi Okawa, Shinji Kiuchi, Hideo Ono, Mitsuru Mizuno, Ichiro Sekiya. Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates. J. Orthop. Res.. 2016.02; 35 (6): 1274-1282. ( PubMed, DOI )

  179. Chisato Sato, Yoshitaka Iso, Takuya Mizukami, Koji Otabe, Masahiro Sasai, Masaaki Kurata, Takeyuki Sanbe, Ichiro Sekiya, Akira Miyazaki, Hiroshi Suzuki. Fibroblast growth factor-23 induces cellular senescence in human mesenchymal stem cells from skeletal muscle. Biochem. Biophys. Res. Commun.. 2016.02; 470 (3): 657-662. ( PubMed, DOI )

  180. Yusuke Nakagawa, Takeshi Muneta, Koji Otabe, Nobutake Ozeki, Mitsuru Mizuno, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo. PLoS ONE. 2016.02; 11 (2): e0148777. ( PubMed, DOI )

  181. Yusuke Nakagawa, Ichiro Sekiya, Shimpei Kondo, Takashi Tabuchi, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Takeshi Muneta. Relationship between MRI T1 rho value and histological findings of intact and radially incised menisci in microminipigs. J Magn Reson Imaging. 2016.02; 43 (2): 434-445. ( PubMed, DOI )

  182. Muneta T, Koga H, Nakamura T, Horie M, Watanabe T, Yagishita K, Sekiya I. A new behind-remnant approach for remnant-preserving double-bundle anterior cruciate ligament reconstruction compared with a standard approach Knee Surg Sports Traumatol Arthrosc. 2015.12; 23 (12): 3743-3749.

  183. Toshifumi Watanabe, Takeshi Muneta, Ichiro Sekiya, Scott A Banks. Intraoperative joint gaps and mediolateral balance affect postoperative knee kinematics in posterior-stabilized total knee arthroplasty. Knee. 2015.12; 22 (6): 527-534. ( PubMed, DOI )

  184. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Akifumi Matsuyama, Ichiro Sekiya. Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells. Stem Cell Res Ther. 2015.12; 6 (1): 243. ( PubMed, DOI )

  185. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Effect of Initial Graft Tension on Knee Stability and Graft Tension Pattern in Double-Bundle Anterior Cruciate Ligament Reconstruction. Arthroscopy. 2015.09; 31 (9): 1756-1763. ( PubMed, DOI )

  186. Kivanc Atesok, Freddie H Fu, Ichiro Sekiya, Alexandra Stolzing, Mitsuo Ochi, Scott A Rodeo. Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential. Knee Surg Sports Traumatol Arthrosc. 2015.08; 25 (2): 626-636. ( PubMed, DOI )

  187. Ichiro Sekiya, Takeshi Muneta, Masafumi Horie, Hideyuki Koga. Arthroscopic Transplantation of Synovial Stem Cells Improves Clinical Outcomes in Knees With Cartilage Defects. Clin. Orthop. Relat. Res.. 2015.07; 473 (7): 2316-2326. ( PubMed, DOI )

  188. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Evaluation of a behind-remnant approach for femoral tunnel creation in remnant-preserving double-bundle anterior cruciate ligament reconstruction - Comparison with a standard approach. Knee. 2015.06; 22 (3): 249-255. ( PubMed, DOI )

  189. Nobutake Ozeki, Takeshi Muneta, Seiya Matsuta, Hideyuki Koga, Yusuke Nakagawa, Mitsuru Mizuno, Kunikazu Tsuji, Yo Mabuchi, Chihiro Akazawa, Eiji Kobayashi, Tomoyuki Saito, Ichiro Sekiya. Synovial mesenchymal stem cells promote meniscus regeneration augmented by an autologous Achilles tendon graft in a rat partial meniscus defect model. Stem Cells. 2015.06; 33 (6): 1927-1938. ( PubMed, DOI )

  190. Yusuke Ogata, Yo Mabuchi, Mayu Yoshida, Eriko Grace Suto, Nobuharu Suzuki, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS ONE. 2015.06; 10 (6): e0129096. ( PubMed, DOI )

  191. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Effect of Posterolateral Bundle Graft Fixation Angles on Clinical Outcomes in Double-Bundle Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. Am J Sports Med. 2015.05; 43 (5): 1157-1164. ( PubMed, DOI )

  192. Yusuke Nakagawa, Takeshi Muneta, Shimpei Kondo, Mitsuru Mizuno, Kazuo Takakuda, Shizuko Ichinose, Takashi Tabuchi, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs. Osteoarthr. Cartil.. 2015.05; 589 (11): 1240-1248. ( PubMed, DOI )

  193. Kahaer Abula, Takeshi Muneta, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Makiko Inoue, Ichiro Sekiya, Daniel Graf, Aris N Economides, Vicki Rosen, Kunikazu Tsuji. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett.. 2015.05; 589 (11): 1240-1248. ( PubMed, DOI )

  194. Yu Matsukura, Takeshi Muneta, Kunikazu Tsuji, Kazumasa Miyatake, Jun Yamada, Kahaer Abula, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya. Mouse synovial mesenchymal stem cells increase in yield with knee inflammation. J. Orthop. Res.. 2015.02; 33 (2): 246-253. ( PubMed, DOI )

  195. Koji Otabe, Hiroyuki Nakahara, Akihiko Hasegawa, Tetsuya Matsukawa, Fumiaki Ayabe, Naoko Onizuka, Masafumi Inui, Shuji Takada, Yoshiaki Ito, Ichiro Sekiya, Takeshi Muneta, Martin Lotz, Hiroshi Asahara. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J. Orthop. Res.. 2015.01; 33 (1): 1-8. ( PubMed, DOI )

  196. Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta. Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan. Int J Inflam. 2014.12; 959271. ( PubMed, DOI )

  197. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Ichiro Sekiya. Effect of femoral tunnel position on graft tension curves and knee stability in anatomic double-bundle anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2014.11; 22 (11): 2811-2820. ( PubMed, DOI )

  198. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Mid- to Long-term Results of Single-Bundle Versus Double-Bundle Anterior Cruciate Ligament Reconstruction: Randomized Controlled Trial. Arthroscopy. 2014.09; ( PubMed, DOI )

  199. Takeshi Muneta, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Toshifumi Watanabe, Kazuyoshi Yagishita, Ichiro Sekiya. A new behind-remnant approach for remnant-preserving double-bundle anterior cruciate ligament reconstruction compared with a standard approach. Knee Surg Sports Traumatol Arthrosc. 2014.09; ( PubMed, DOI )

  200. D Hatsushika, T Muneta, T Nakamura, M Horie, H Koga, Y Nakagawa, K Tsuji, S Hishikawa, E Kobayashi, I Sekiya. Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model. Osteoarthr. Cartil.. 2014.07; 22 (7): 941-950. ( PubMed, DOI )

  201. Makiko Okuno, Takeshi Muneta, Hideyuki Koga, Nobutake Ozeki, Yusuke Nakagawa, Kunikazu Tsuji, Shinichi Yoshiya, Ichiro Sekiya. Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model. J. Orthop. Res.. 2014.07; 32 (7): 928-936. ( PubMed, DOI )

  202. Nobuharu Suzuki, Chihiro Mizuniwa, Kana Ishii, Yusuke Nakagawa, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation. J. Orthop. Res.. 2014.07; 32 (7): 915-922. ( PubMed, DOI )

  203. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Ichiro Sekiya. Effect of Notchplasty in Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2014.06; 42 (8): 1813-1821. ( PubMed, DOI )

  204. Ichiro Sekiya, Seth S Leopold. Editor's spotlight/Take 5: Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin. Orthop. Relat. Res.. 2014.05; 472 (5): 1353-1356. ( PubMed, DOI )

  205. Yu Matsukura, Takeshi Muneta, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin. Orthop. Relat. Res.. 2014.05; 472 (5): 1357-1364. ( PubMed, DOI )

  206. Tomomasa Nakamura, Ichiro Sekiya, Takeshi Muneta, Eiji Kobayashi. [Articular cartilage regenerative therapy with synovial mesenchymal stem cells in a pig model]. Clin Calcium. 2013.12; 23 (12): 1741-1749. ( PubMed, DOI )

  207. Koga Hideyuki, Muneta Takeshi, Yagishita Kazuyoshi, Ju Young-Jin, Sekiya Ichiro. Surgical management of grade 3 medial knee injuries combined with cruciate ligament injuries. Knee Surg Sports Traumatol Arthrosc. 2012.01; 20 (1): 88-94. ( PubMed, DOI )

  208. Koga H, Muneta T, Yagishita K, Ju YJ, Sekiya I. The Effect of Graft Fixation Angles on Anteroposterior and Rotational Knee Laxity in Double-Bundle Anterior Cruciate Ligament Reconstruction: Evaluation Using Computerized Navigation Am J Sports Med. 2012;

  209. Nakamura T, Sekiya I, Muneta T, Hatsushika D, Horie M, Tsuji K, Kawarasaki T, Watanabe A, Hishikawa S, Fujimoto Y, Tanaka H, Kobayashi E. Arthroscopic, histological, and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stem cells into cartilage defects in pigs Cytotherapy. 2012;

  210. Sekiya I, Morito T, Hara K, Yamazaki J, Ju YJ, Yagishita K, Mochizuki T, Tsuji K, Muneta T. Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. AAPS PharmSciTech. 2010.03; 11 (1): 154-158. ( PubMed, DOI )

  211. Sekiya I, Tang T, Hayashi M, Morito T, Ju YJ, Mochizuki T, Muneta T. Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats. J Orthop Res. 2009.08; 27 (8): 1088-1092. ( PubMed, DOI )

  212. Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ. Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res. 2005.05; 320 (2): 269-276. ( PubMed, DOI )

  213. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Nifuji A, Noda M. Dexamethasone enhances SOX9 expression in chondrocytes. J Endocrinol. 2001.06; 169 (3): 573-579. ( PubMed )

  214. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Niguji A, Noda M. Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid. J Cell Biochem Suppl. 2001; Suppl 36 71-78. ( PubMed )

  215. Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem. 2000.04; 275 (15): 10738-10744. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. Yuki Hidaka, Kentaro Endo, Ichiro Sekiya. Single-cell RNA Sequencing Analysis Of Human Synovial And Adipose Mesenchymal Stem Cells For Knee Osteoarthritis Treatment. Orthopaedic Research Society 2024 Annual Meeting 2024.02.02 California,USA

  2. Hideto Furuoka, Kentaro Endo, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis. Orthopaedic Research Society 2024 Annual Meeting 2024.02.02 California,USA

  3. Ichiro Sekiya. Fully automatic 3D MRI analysis showed that synovial MSC injections suppressed cartilage loss in patients with progres-sive OA. The 13th Meeting of Asian Cell Therapy Orgnization (ACTO) 2022.09.23 WEB, Taiwan

  4. Ichiro Sekiya. Is meniscal injury a cause or a consequence in osteoarthritis?. 16th International Workshop on Osteoarthritis Imaging 2022.07.08 Tokyo Japan

  5. Sekiya Ichiro, Katano Hisako, Koga Hideyuki, Tomita Makoto, Suzuki Kenji, Masumoto Jun, Okawa Atsushi, Ozeki Nobutake. 変形性膝関節症における内側半月板内縁からの軟骨欠損(Cartilage defects extend from the medial margin of medial meniscus in knee osteoarthritis). 日本整形外科学会雑誌 2022.03.01

  6. Sekiya Ichiro, Katano Hisako, Koga Hideyuki, Tomita Makoto, Suzuki Kenji, Masumoto Jun, Okawa Atsushi, Ozeki Nobutake. 変形性膝関節症における内側半月板内縁からの軟骨欠損(Cartilage defects extend from the medial margin of medial meniscus in knee osteoarthritis). 日本整形外科学会雑誌 2022.03.01

  7. Ichiro Sekiya. Medial tibial osteophyte width strongly reflects medial meniscus extrusion distance and medial joint space width moderately reflects cartilage thickness in knee radiographs. MUSCULOSKELETAL WORKSHOP SERIES 2022.02.06 WEB

  8. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Hiroki Katagiri, Hisako Katano, Makoto Tomita, Jun Masumoto, Ichiro Sekiya.. Relationship Between Cartilage Thickness By 3D MRI Analysis And ICRS Arthroscopic Grade In The Knee Joint.. Orthopaedic Research Society 2022 Annual Meeting 2022.02.05 Tampa,USA

  9. Ichiro Sekiya. Intraarticular injections of mesenchymal stem cells in knee osteoarthritis.. Osteoarthritis Research Society International 2021 2021.04.29 WEB

  10. Nobutake Ozeki, Hiroki Katagiri, Yusuke Nakagawa , Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya, Hideyuki Koga.. Ramp lesions in anterior cruciate ligament deficient knees.. 2ND INTERNATIONAL KENN DAY 2021.03.18 WEB

  11. Yugo Miura, Nobutake Ozeki, Yuji Kohno, Hisako Katano, Hayato Aoki, Noriya Okanouchi, Makoto Tomita, Kenji Suzuki, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Difference In The Joint Space Of The Medial Knee Compartment Between Full Extension And Rosenberg Weight-bearing Radiographs.. Orthopaedic Research Society 2021 Annual Meeting 2021.02.12 California,USA

  12. Nobutake Ozeki, Hideyuki Koga,Tomomasa Nakamura,Yusuke Nakagawa, Yuji Kohno, Hisako Katano, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya.. 3D MRI Analysis For Cartilage In Anterior Cruciate Ligament Deficient Knees Using Radially Projected Images.. Orthopaedic Research Society 2021 Annual Meeting 2021.02.12 California,USA

  13. Seki Yoshie, Katagiri Hiroki, Otabe Koji, Nakagawa Yusuke, Miyatake Kazumasa, Sekiya Ichiro, Koga Hideyuki. 人工関節全置換術前の関節内麻酔テストと術後の持続性疼痛の関連の検討(Investigation of association between the preoperative intra-articular anesthetic test and persistent pain after total knee arthroplasty). Journal of Orthopaedic Science 2020.11.01

  14. Akinobu Hyodo. Nobutake Ozeki, Hayato Aoki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya.. Radial Projected Femoral Cartilage Area By Automatic Cartilage Segmentation For The Knee MRI.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.11 Phoenix,USA

  15. Yoshihisa Kushida, Nobutake Ozeki, Hisako Katano, Mitsuru Mizuno, Ichiro Sekiya.. 2D And 3D Optical Coherence Tomography To Differentiate Degenerative Changes In A Rat Meniscectomy Model.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.11 Phoenix,USA

  16. So Suzuki, Mitsuru Mizuno, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantitative Morphological Analysis Of Synovial Mesenchymal Stem Cells During Adhesion To The Meniscus.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.10 Phoenix,USA

  17. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Tsuyoshi Kimura, Kunikazu Tsuji, Akio Kishida, Ichiro Sekiya.. The Amount Of Collagen Is Not Related To Mechanical Properties Of High Hydrostatic Pressure-decellularized Meniscus And Freeze-thawed Meniscus.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.09 Phoenix,USA

  18. Hayato Aoki, Nobutake Ozeki, Akinobu Hyodo, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kenji Suzuki, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Learning Times And Segmentation Accuracy Of U-net Convolutional Neural Networks On Automatic Segmentation For Mri Of Knee.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.09 Phoenix,USA

  19. Nobutake Ozeki, Hideyuki Koga, Hayato Aoki, Akinobu Hyodo, Hiroki Katagiri, Yusuke Nakagawa, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya.. 3D MRI Analysis For Cartilage In Anterior Cruciate Ligament Deficient Knee.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  20. Kiyotaka Horiuchi, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Comparison Between Cultured Mscs And Non-cultured Mscs After Cryopreservation For Intra-articular Injections Into The Knee In A Rat Oa Model.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  21. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Yuji Kohno, Junpei Matsuda, Yoshihisa Kushida, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Ichiro Sekiya.. The Effect Of Centralization Procedure For Extruded Lateral Meniscus On Load Distributionin Porcine Knee Joints At 30-90 Degrees Of Flexion.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  22. Ichiro Sekiya. Regeneration of Degenerated Meniscus by Synovial Stem Cells : Evaluation by 3D MRI. The Koret Foundation Lecture 2019.11.05 Davis,USA

  23. Akinobu Hyodo,Nobutake Ozeki, Yuji Kohno, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Makoto Tomita, Yusuke Nakagawa, Hideyuki Koga, Shinji Kiuchi, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya.. Projected cartilage area ratio determined by 3D MRI analysis: a validation of a novel technique to evaluate articular cartilage.. 13th International Workshop on Osteoarthritis Imaging 2019.06.26 Charlottetown, Canada

  24. Nobutake Ozeki, Hideyuki Koga, Hayato Aoki, Akinobu Hyodo, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya. . 3D MRI analysis for cartilage in anterior cruciate ligament injured knees.. 13th International Workshop on Osteoarthritis Imaging 2019.06.26 Charlottetown, Canada

  25. Hayato Aoki, Nobutake Ozeki, Akinobu Hyodo, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya.. Learning times and segmentation accuracy of U-Net Convolutional Neural Networks on automatic segmentation for MRI of knee.. 13th International Workshop on Osteoarthritis Imaging 2019.06.26 Charlottetown, Canada

  26. So Suzuki, Mitsuru Mizuno, Yoshihisa Kushida, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Shizuko Ichinose, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Morphological Alterations Of Synovial Mesenchymal Stem Cells During Adhesion To The Meniscus.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  27. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantification Of Cartilage Volume By 3D Color Optical Coherence Tomography In A Meniscectomized Rat Model.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  28. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Use Of 3D MRI And 3D T2 Mapping Images For Evaluation Of The Natural Course Of Cartilage Repair In The Knees Of Micromini Pigs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  29. Yuji Kohno, Mitsuru Mizuno, Otabe Koji, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Kog, Ichiro Sekiya.. Yields Of MSCs From Synovial Fluid Reflect Yields Of MSCs From The Synovium Of RA Knees.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  30. Naoto Watanabe, Nobutake Ozeki, Mitsuru Mizuno, Keiichiro Komori, Yuji Kohno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantitative Analysis Of Mesenchymal Stem Cells (MSCs) In Synovial Fluid Two Weeks After Synovial Removal And Meniscus Repair, Followed By Transplantation Of Synovial MSCs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  31. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya.. Comparison Of Decellularized Meniscus By High Hydrostatic Pressure With Freeze-thawed Meniscus.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  32. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Time Lapse Imaging Analysis On Colony Proliferation Process Of Primary Synovial Mscs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  33. Kiyotaka Horiuchi, Hideyuki Koga, Mitsuru Mizuno, Hisako Katano, Keiichiro Komori, Koji Otabe, Shizuka Fujii, Nobutake Ozeki, Tsujii Kunikazu, Ichiro Sekiya.. Determining The Optimum Initial Cell Density That Yields The Highest Number Of Mesenchymal Stem Cells Per Dish.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  34. Hayato Aoki, Nobutake Ozeki, Akinobu Hyodo, So Suzuki, Yoshihisa Kushida, Naoto Watanabe, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Whole Image Of Discoid Lateral Meniscus Analyzed By 3d Mri.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  35. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Cryopreservation In 95% Serum With 5% Dmso Maintained Colony Formation And Chondrogenic Abilities In Human Synovial Mesenchymal Stem Cells.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  36. So Suzuki, Nobutake Ozeki, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Keniji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Medial Meniscus Extrusion (MME) Area And MME Volume Determined By 3D-MRI Are More Sensitive Than Mme Distance Determined By 2D-MRI For Evaluating Cartilage Loss In Knees With Medial Meniscus Degenerative Tears.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  37. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Yuji Kohno, Junpei Matsuda, Yoshihisa Kushida, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Ichiro Sekiya.. Influence Of Knee Flexion Angle On The Biomechanical Effect Of Centralization For Extruded Lateral Meniscus. Orthopaedic Research Society 2019 Annual Meeting 2019.02.02 Austin,USA

  38. Akinobu Hyodo, Nobutake Ozeki, So Suzuki, Hayato Aoki, Naoto Watanabe, Yoshihisa Kushida, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. “Projected Cartilage Area Ratio” By Mri 3d Analysis Detects Decrease Of Cartilage Amount In Several Months In Patients Complaining Knee Pain.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.02 Austin,USA

  39. Ichiro Sekiya. Transplantation of synovial mesenchymal stem cells onto repaired menisci with degenerative tears: a 2-year follow-up study. ICRS Focus Meeting 2018.12.13 Milano,Italy

  40. Ichiro Sekiya. Transplantation of synovial mesenchymal stem cells onto repaired meniscus with degenerative tear. 5th TERMIS World Congress-2018 2018.09.05 Kyoto, Japan

  41. Horie Masafumi, Katagiri Hiroki, Watanabe Toshifumi, Otabe Koji, Ohara Toshiyuki, Katagiri Kenta, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. Early intervention on early knee osteoarthritis focusing on the medial meniscus posterior root tear　内側半月板逸脱を伴う変形性膝関節症に対する鏡視下半月板セントラリゼーションを併用した高位脛骨骨切り術の臨床成績(Early intervention on early knee osteoarthritis focusing on the medial meniscul posterior root tear　Clinical outcomes after medial open-wedge high tibial osteotomy combined with arthroscopic medial meniscus centralization for medial compartment OA with meniscal extrusion). JOSKAS 2018.05.01

  42. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Sekiya Ichiro, Muneta Takeshi. Meniscal Repair up to date　逸脱半月板に対する治療戦略(Meniscal Repair up to date　Meniscus repair up to date: Treatment strategy for meniscus extrusion). JOSKAS 2018.05.01

  43. Koga Hideyuki, Katakura Mai, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Sekiya Ichiro, Muneta Takeshi. How to eliminate residual instability in ACLR　ACL再建術後の残存不安定性の制動　回旋不安定性と半月板(How to eliminate residual instability in ACLR　How to eliminate residual instability in ACLR: Rotational instability and Meniscus). JOSKAS 2018.05.01

  44. Sekiya Ichiro, Koga Hideyuki, Otabe Koji, Nakagawa Yusuke, Katano Hisako, Ozeki Nobutake, Mizuno Mitsuru, Horie Masafumi, Muneta Takeshi. Regenerative medicine in Knee　変性半月板断裂に対する修復+滑膜幹細胞移植の2年成績(Regenerative medicine in Knee　Transplantation of synovial stem cells onto degenerative torn meniscus: a 2-year follow-up study). JOSKAS 2018.05.01

  45. Ochi Miharu, Ozeki Nobutake, Muneta Takeshi, Koga Hideyuki, Sekiya Ichiro. 滑膜幹細胞およびBMP2による腱の軟骨形成(Cartilage formation of tendon with synovial stem cells and BMP2). JOSKAS 2018.05.01

  46. Watanabe Toshifumi, Muneta Takeshi, Sekiya Ichiro, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katagiri Kenta, Koga Hideyuki. アジアからの人工膝関節　ACTIYAS　インプラントデザイン、外科手術のコツ、および臨床成績(Knee Prostheses from Asia　ACTIYAS: Implant design, surgical tips, and clinical outcomes). JOSKAS 2018.05.01

  47. Horie Masafumi, Katagiri Hiroki, Watanabe Toshifumi, Otabe Koji, Ohara Toshiyuki, Katagiri Kenta, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. Early intervention on early knee osteoarthritis focusing on the medial meniscus posterior root tear　内側半月板逸脱を伴う変形性膝関節症に対する鏡視下半月板セントラリゼーションを併用した高位脛骨骨切り術の臨床成績(Early intervention on early knee osteoarthritis focusing on the medial meniscul posterior root tear　Clinical outcomes after medial open-wedge high tibial osteotomy combined with arthroscopic medial meniscus centralization for medial compartment OA with meniscal extrusion). JOSKAS 2018.05.01

  48. Ochi Miharu, Ozeki Nobutake, Muneta Takeshi, Koga Hideyuki, Sekiya Ichiro. 滑膜幹細胞およびBMP2による腱の軟骨形成(Cartilage formation of tendon with synovial stem cells and BMP2). JOSKAS 2018.05.01

  49. Watanabe Toshifumi, Muneta Takeshi, Sekiya Ichiro, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katagiri Kenta, Koga Hideyuki. アジアからの人工膝関節　ACTIYAS　インプラントデザイン、外科手術のコツ、および臨床成績(Knee Prostheses from Asia　ACTIYAS: Implant design, surgical tips, and clinical outcomes). JOSKAS 2018.05.01

  50. Sekiya Ichiro, Koga Hideyuki, Otabe Koji, Nakagawa Yusuke, Katano Hisako, Ozeki Nobutake, Mizuno Mitsuru, Horie Masafumi, Muneta Takeshi. Regenerative medicine in Knee　変性半月板断裂に対する修復+滑膜幹細胞移植の2年成績(Regenerative medicine in Knee　Transplantation of synovial stem cells onto degenerative torn meniscus: a 2-year follow-up study). JOSKAS 2018.05.01

  51. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Sekiya Ichiro, Muneta Takeshi. Meniscal Repair up to date　逸脱半月板に対する治療戦略(Meniscal Repair up to date　Meniscus repair up to date: Treatment strategy for meniscus extrusion). JOSKAS 2018.05.01

  52. Koga Hideyuki, Katakura Mai, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Sekiya Ichiro, Muneta Takeshi. How to eliminate residual instability in ACLR　ACL再建術後の残存不安定性の制動　回旋不安定性と半月板(How to eliminate residual instability in ACLR　How to eliminate residual instability in ACLR: Rotational instability and Meniscus). JOSKAS 2018.05.01

  53. 水野 満, 片野 尚子, 藤井 静花, 辻 彩子, 関矢 一郎, 森尾 友宏. 東京医科歯科大学における 細胞調製施設運営の実例と課題. 第17回日本再生医療学会総会 2018.03.21 横浜

  54. Naoto Watanabe, Mitsuru Mizuno, Jumpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kono, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Can Decellularized Meniscus by High Hydrostatic Pressure be an Alternative to Meniscus Allograft? - Compared with Deep Frozen Meniscus. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  55. Yoshihisa Kushida, Koichiro Kishima Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Pseudo Color Images and Volume Measurement of Cartilage by Optical Coherence Tomography in a Rat Meniscectomized Model. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  56. Hayato Aoki, Nobutake Ozeki, Kohno yuji, Kushida Yoshihisa, Naoto Watanabe, Akinobu Hyodo, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Mri 3d Analysis For Discoid Lateral Meniscus Of The Knee. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  57. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Keiichiro Komori, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Koga Hideyuki, Ichiro Sekiya. Image Analysis Method to Predict Cell Proliferation at Early Phase for Autologous Synovial Stem Cell Transplantation. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  58. Koji Otabe, Kenta Katagiri, Toshiyuki Ohara, Hiroki Katagiri, Masafumi Horie, Toshifumi Watanabe, Hideyuki Koga, Ichiro Sekiya. Wide Oval Gantry 3.0T MRI Analysis Revealed Dynamic Knee Neurovascular Transposition During Flexion of the Knee. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  59. Miharu Ochi, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Effects of synovial stem cells and BMP-2 on cartilage formation of tendon. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  60. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Investigation of Freezing Medium for Synovial Mesenchymal Stem Cells. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  61. Akari Sasaki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya. Comparison Of Canine Mesenchymal Stem Cells Derived From Synovium, Infrapatellar Fat Pad, Subcutaneous Adipose Tissue And Bone Marrow. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  62. Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Shizuko Ichinose, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Petaloid Recombinant Peptide Constructs the Framework of Cartilage Pellet and Promotes In Vitro Cartilage Formation. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  63. Yuji Kohno, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Ichiro Sekiya. Biomechanical analysis of meniscus centralization for extruded meniscus after meniscectomy. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11

  64. Yuji Kohno, Nobutake Ozeki, Akinobu Hyodo, So Suzuki, Hayato Aoki, Yoshihisa Kushida, Naoto Watanabe, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Validations for cartilage thickness, cartilage area ratio and meniscus volume in the knee by 3D MRI analysis. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans

  65. Nobutake Ozeki, Yuji Kohno, Yoshihisa Kushida, Naoto Watanabe, Kenta Katagiri, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Tomoyuki Saito, Ichiro Sekiya. Three-Dimensional MRI, T2 Mapping and Histological Analyses of Meniscus Repair After Transplantation of Synovial Mesenchymal Stem Cells in a Novel Degenerative Meniscus Injury Model in Pig . Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  66. So Suzuki, Nobutake Ozeki, Akinobu Hyodo, Hayato Aoki, Yoshihisa Kushida, Naoto Watanabe, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. "Cartilage Area Ratio"by MRI 3D Analysis Reveals Subtle Change of Cartilage Volume in Middle Aged Patients with Medeal Meniscus Degenerative Tear. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  67. Sekiya Ichiro. 動物モデルから臨床応用へ　膝関節の再生医療　疾患モデルから臨床治療へ(From Animal Models to Clinics　Regenerative medicine for the knee joint: from disease models to clinical treatments). Experimental Animals 2017.06.01

  68. Sekiya Ichiro. 動物モデルから臨床応用へ　膝関節の再生医療　疾患モデルから臨床治療へ(From Animal Models to Clinics　Regenerative medicine for the knee joint: from disease models to clinical treatments). Experimental Animals 2017.06.01

  69. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Sekiya Ichiro, Muneta Takeshi. すべてが分かる半月板損傷の治療　半月板突出の関節鏡下centralization法と膝関節症における膝関節機能回復のための本手術法の応用(Arthroscopic Centralization of an Extruded Meniscus and Its Application to Knee Osteoarthritis to Restore Knee Function). JOSKAS 2017.05.01

  70. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Sekiya Ichiro, Muneta Takeshi. すべてが分かる半月板損傷の治療　半月板突出の関節鏡下centralization法と膝関節症における膝関節機能回復のための本手術法の応用(Arthroscopic Centralization of an Extruded Meniscus and Its Application to Knee Osteoarthritis to Restore Knee Function). JOSKAS 2017.05.01

  71. Yuji Kono, Mitsuru Mizuno, Kenta Katagiri, Koji Otabe, Nobutake Ozeki, Hisako Katao, Keiichiro Komori, Masafuji Horie, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaeko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya.. Harvested cell number varies greater in RA than in OA after a suspended synovium culture. Orthopaedic Research Society 2017 Annual Meeting 2017.03.22 SanDiego, USA

  72. Kenta Katagiri, Mitsuru Mizuno, Hideyuki Koga, Nobutake Ozeki, Yusuke Nakagawa, Yuji Kono, Koji Otabe, Masafumi Horie, Hisako Katano,Kunikazu Tsuji, Hideo Ono, Takeshi Muneta, Ichiro Sekiya.. Transplantation of Synovial Mesenchymal Stem Cells Enhances the Effect of Cetralization with Suture Anchor and Promotes Meniscus Regeneration for Extruded Meniscus After Partial Meniscectomy in Microminipigs. Orthopaedic Research Society 2017 Annual Meeting 2017.03.22 SanDiego, USA

  73. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya.. Complete Human Serum Maintains Viability and Chondrogenic Potential of Human Synovial Stem Cells: Suitable Condition for Transplantation. Orthopaedic Research Society 2017 Annual Meeting 2017.03.21 SanDiego, USA

  74. Koji Otabe, Mai Katakura, Toshiyuki Ohara, Kaori Nakamura, Masafumi Horie, Hideyuki Koga, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta.. Automatic Knee X Ray Analysis System Reveals that Meniscus Repair during Anterior Cruciate Ligament Reconstruction Surgery cannot prevent the Development of Osteoarthritis. Orthopaedic Research Society 2017 Annual Meeting 2017.03.21 SanDiego, USA

  75. Naoto Watanabe, Mitsuru Mizuno, Jumpei Matsuda, Hisako Katano, Nobutake Ozeki, Koji Otabe, Keiichiro Komori, Yuji Kono, Kenta Katagiri, Takeshi Muneta, Ichiro Sekiya.. Decellularization of the meniscus by high hydrostatic pressure: temperature condition for removal of cell debris.. Orthopaedic Research Society 2017 Annual Meeting 2017.03.20 SanDiego, USA

  76. Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya.. Recombinant peptide petaloid pieces enhance in vitro cartilage formation of mesenchymal stem cells. Orthopaedic Research Society 2017 Annual Meeting 2017.03.20 SanDiego, USA

  77. Ichiro Sekiya. Preclinical and Clinical Studies of Meniscus Regeneration by Synovial Stem Cells. Orthopaedic Research Society 2017 Annual Meeting 2017.03.19 SanDiego, USA

  78. Ichiro Sekiya. Scientific update: the synovial joint milieu - implications for cartilage repair. ICRS World Congress 2016.09.23 Naples,Italy

  79. Ichiro Sekiya. Adult stem cell-based approaches (Intraarticular delivery, model systems vs humans) Overview. ICRS Summit 2016.04.10 Kyoto, JAPAN

  80. Nobutake Ozeki, Junpei Matsuda, Takeshi Muneta, Hideyuki Koga, Kunikazu Tsuji, Kenta Katagiri, Mitsuru Mizuno, Tomoyuki Saito, Ichiro Sekiya. Biomechanical Analysis of Centralization With an Anchor for Meniscus Extrusion in a Porcine Model. Orthopaedic Research Society 2016 Annual Meeting 2016.03.07 Orlando, USA

  81. Yusuke Nakagawa, Hideyuki Koga, Takeshi Muneta, Shinji Kiuchi, Hideo Ono, Tsuyoshi Nagata, Toshifumi Watanabe, Masafumi Horie, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Mai Katakura, Hisako Katano, Ichiro Sekiya. Three-Dimensional Reconstructed MRI Evaluation of Arthroscopic Centralization Technique for Extruded Lateral Meniscus. Orthopaedic Research Society 2016 Annual Meeting 2016.03.07 Orlando, USA

  82. Koji Otabe, Ken Watanabe, Norio Shimizu, Takeshi Muneta, Ichiro Sekiya. High Sensitivity Virus / Mycoplasma Screening Test Reveals High Prevalence of Parvovirus B19 Infection In Synovial Tissues and Bone Marrow. Orthopaedic Research Society 2016 Annual Meeting 2016.03.06 Orlando, USA

  83. Kenta Katagiri, Takeshi Muneta, Koji Otabe, Yu Matsukura, Hisako Katano,Ichiro Sekiya. Fibrous Synovium Releases Higher Number Of MSCs Than Adipose Synovium in a Suspended Synovium Culture Model. Orthopaedic Research Society 2016 Annual Meeting 2016.03.06 Orlando, USA

  84. Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Nobutake Ozeki, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta, Ichiro Sekiya. Properties of MSCs Derived From Surface, Stroma, and Perivascular Synovium Of Oa Patients. Orthopaedic Research Society 2016 Annual Meeting 2016.03.06 Orlando, USA

  85. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto,Nobutake Ozeki, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya. PDGF-AA/AB In Human Serum Are Potential Indicators Of The Proliferative Capacity Of Human Synovial Mesenchymal Stem Cells. Orthopaedic Research Society 2016 Annual Meeting 2016.03.06 Orlando, USA

  86. Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya. Interleukin-1β Promotes In Vitro Chondrogenesis Of Synovial Mesenchymal Stem Cells. Orthopaedic Research Society 2016 Annual Meeting 2016.03.06 Orlando, USA

  87. Ichiro Sekiya. Cartilage and meniscus regeneration by synovial stem cells:from bench to clinic. Japan visit program for Dutch delegation on Sport Science 2015.11.12 Tokyo, Japan

  88. Ichiro Sekiya. Arthroscopic transplantation of synovial stem cells for cartilage injury. APKAS Summitt 2015.05.08 taipei,TAIWAN

  89. Ichiro Sekiya. Synovial Mesenchymal Stem Cells to Repair/Reverse Knee OA: From Bench to Clinic. Orthopaedic Research Society 2015 Annual Meeting 2015.03.28 Las Vegas, USA

  90. Ichiro Sekiya. Synovial stem cells promote healing after surgical meniscal repair. International Early Knee OA Symposium 2014.11.05 Tokyo, Japan

  91. Ichiro Sekiya. Cartilage and meniscus regeneration with synovial stem cells. GCOE Symposium 2014.02.18 Tokyo, Japan

  92. Ichiro Sekiya. Introduction for the “Center for Stem Cell and Regenerative Medicine” at TMDU: “Cartilage and meniscus regeneration with synovial MSCs” as a representative case to establish a platform for the realization of regenerative medicine . GCOE Symposium 2014.02.18 Tokyo, Japan

  93. J Yamada,K Tsuji,K Miyatake,Y Matsukura,A Kahar,Y Arai,I Sekiya,T Muneta. Forced running (60km in 6wks) reverses bone and articular cartilage degeneration induced by ovariectomy in C57Bl/6 mice. 2013 ORS 2013.01.26 San Antonio

  94. Miyatake Kazumasa,Tsuji Kunikazu,Yamada Jun,Matsukura Yu,Abula Kahaer,Arai Yoshinori,Sekiya Ichiro,Muneta Takeshi. Articular cartilage degeneration and synovitis observed in the ovariectomized mice are greatly exacerbated by forced running. 2013　ORS 2013.01.26 San Antonio

  95. Daisuke Hatsushika; Ichiro Sekiya; Masafumi Horie; Takeshi Muneta. Intraarticular injection of synovial stem cells promotes meniscal regeneration in rabbit massive meniscal defect. ORS 2012 Annual Meeting 2012.12.06 Sanfrancisco

  96. Ozeki N, Sekiya I, Saito T, Muneta T. Transplantation of Achilles tendon treated with BMP-7 promoted meniscus regeneration in a rat massive meniscus defect model. 11th World Congress of the international cartilage repair society 2012.05.12 Montreal, Canada

  97. Miyatake, Tsuji, Yamada, Kahaer, Matsukura, Sekiya, Muneta. Articular cartilage degradation induced by extensive treadmill exercise is greatly exacerbated by estrogen depletion in mice. 2013　OARSI 2012.04.26 Barcelona

  98. Ozeki N, Sekiya I, Saito T, Muneta T. Transplantation of Achilles tendon treated with BMP-7 promoted meniscus regeneration in a rat massive meniscus defect model. World Congress on Osteoarthritis 2012.04.26 Barcerona, Spain

  99. Kahaer Abula, Takeshi Muneta, Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. BMP7 is prerequisite for postnatal joint homeostasis. The 25th Annual Meeting of The Japanese Society of Cartilage Metabolism 2012.03.09 Nagoya, Japan

  100. Horie M, Choi H, Sekiya I, Muneta T, Prockop D J. Xenografts of Human Mesenchymal Stromal Cells (MSCs) Improve Repair of Rat Meniscus by Being Activated to Express Indian Hedgehog that Enhances Expression of Rat Type II Collagen. Orthopaedic Research Society 2012 Annual Meeting 2012.02.05 San Francisco, USA

  101. Otabe, K; Sekiya, I; Kawashima, N; Tsuji K; Muneta, T. Properties of mesenchymal stem cells derived from removed teeth. 2012 Annual Meeting of the Orthopaedic Research Society 2012.02.04 San Francisco

  102. J,Yamada. K,Miyatake. M,Yamaga.I,Sekiya. T,Muneta. K,Tsuji. Follistatin alleviates articular cartilage degradation induced by carrageenan. 2012　ORS 2012.02.04 San Francisco

  103. Miyatake, K; Yamaga, M　Sekiya, I 　Muneta, T and Tsuji, K . Human chitinase 3-like protein 2 (YKL39) is a novel secreted protein which supports cell proliferation　and chondrocytic differentiation of ATDC5. 2012 ORS 2012.02.04 San Francisco

  104. Ozeki N, Sekiya I, Otabe K, Katagiri H, Okuno M, Tsuji K, Saito T, Muneta T. BMP-7 treated Achilles tendon transplantation for meniscal defect in a rat model. 2012 Annual Meeting of the Orthopaedic Research Society 2012.02.04 San Francisco, USA

  105. Daisuke Hatsushika,Ichiro Sekiya,Tomomasa Nakamura,Masafumi Horie,Hideyuki Koga,Kunikazu TsujiTakes,hi Muneta. Porcine massive meniscal defect is regenerated by intraarticular injections of synovial stem cells. ORS 2013Annual Meeting 2012.01.29 San Antonio

  106. Kahaer Abula, Takeshi Muneta, Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. BMP7 is prerequisite for postnatal joint homeostasis. The 6th Global COE International Symposium 2012.01.23 Tokyo, Japan

  107. Arthroscopic transplantation of synovial stem cells into cartilage defect. Seminar at Orthopaedic Surgery 2008

  108. Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect. Seminar at Center for Gene therapy, Tulane University New Orleans, 2008

  109. Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect. International BMP Conference Lake Tahoe 2008

  110. In Vitro and in Vivo Chondrogenesis of Synovial Mesenchymal Stem Cells. The winter meeting of the Korean Society for OA and Cartilage Research 2008

  111. Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect. Seminar at Orthopaedic Surgery, Stanford University Stanford 2008

  112. Applications of Synovial Mesenchymal Stem Cells for Joint Injuries. Seminar at Orthopaedic Surgery, University of California-Irvine Otange, 2008

  113. Cartilage Regeneration Using Synovial Stem Cells by Arthroscopic Technique. Seminar at Institute of Regenerative Medicine, Texas A&M University Temple 2008

  114. Synovial Fluid-derived Stem Cells Increase After Anterior Cruciate. Ligament Injury in Humans Seminar at Orthopaedic Surgery, University of California-Davis 2008

  115. Cartilage Regeneration Using Synovial Stem Cells. International cell therapy conference 2008

  116. Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect. Seminar at Orthopaedic Surgery, Oregon Health and Science University Portland 2008

  117. Cartilage Regeneration by Transplantation of Synovial Mesenchymal Stem Cells with Low Invasive Technique. Seminar at Orthopaedics, Dongguk University Seoul, Korea 2008

  118. Applications of Synovial Mesenchymal Stem Cells for Joint Injuries. Seminar at Orthopaedic Surgery, University of Texas-Houston Houston, 2008

  119. Applications of Synovial Mesenchymal Stem Cells for Joint Injuries. Seminar at Orthopaedic Surgery, University of New Mexico Albuquerque 2008

  120. Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect. Seminar at Orthopaedic Surgery, Texas Tech University-Lubbock Lubbock, 2008

  121. Cartilage Regeneration by Transplantation of Synovial Mesenchymal Stem Cells with Low Invasive Technique. Veterans General Hospital Orthopaedic Seminar 2007

  122. Cartilage Regeneration by Transplantation of Synovial Mesenchymal Stem Cells with Low Invasive Technique. National Yang Ming University Seminar 2007

  123. Cartilage Regeneration by Transplantation of Synovial Mesenchymal Stem Cells with Low Invasive Technique. Biotechnology Taiwan 2007 2007

  124. 宗田　大、柳下和慶、原憲司、関矢一郎. 人工膝関節置換術の軟部バランスに与える大腿骨切除量の影響. 第３５回日本人工関節学会 2005.02.03 沖縄

  125. 宗田　大、柳下和慶、関矢一郎. シンポジウム私のACL再建術：この10年の進歩. 第29回日本膝関節学会 2004.02.13 広島

  126. 宗田　大、柳下和慶、八木啓介、関矢一郎. 私の2束ACL再建術の反省と現在の試み. 日本リウマチ・関節外科学会 2003.11.08

  127. 宗田　大、柳下和慶、関矢一郎. 多重折半腱様筋腱による前十字靭帯再建術の中長期成績：1ルート法と2ルート法の比較　パネル「ここまできた前十字靭帯再建術」. 第76回日整会 2003.05.24 金沢

  128. 宗田　大，池田浩夫，柳下和慶、関矢一郎，浅野浩司，四宮謙一. 「前十字靭帯再建膝における損傷半月板の治癒能力」ACL再建膝における半月板治癒能力. 日整会 2000.04.09

  129. Applications of synovial mesenchymal stem cells for joint injuries. The Chinese Medical Association (CMA) 2000

  130. 宗田　大, 関矢一郎, 柳下和慶, 長谷川元信, 浅野浩司, 立石智彦, 大久保治修, 山本晴康, 四宮謙一. 膝前十字靭帯再建術後早期スポーツ復帰における問題. 第25回日整会スポーツ 1999.05.28

  131. 宗田　大，荻内隆司，関矢一郎，長谷川元信，栗原良暁*，柳下和慶，山本晴康 四宮謙一. Endobuttonによる移植腱の固定ー特にACL再建に対する2ルート法ー. JOA 1999.04.09 横浜

  132. 宗田　大，柳下和慶，関矢一郎，長谷川元信，山本晴康，四宮謙一. 透視像による各種人工膝関節の最大屈曲位の検討. 第29回日本人工関節学会 1999.01.29 倉敷

  133. 宗田　大，関矢一郎，荻内隆司，柳下和慶，山本晴康，四宮謙一. 前十字靭帯再建術の自覚的回復に影響を与える因子の分析. 第71回日整会 1998.04.20 徳島

  134. Takeshi Muneta, Ichiro Sekiya, Kazuyoshi Yagishita, Takashi Ogiuchi and Haruyasu Yamamoto. Two-bundle anatomic reconstruction of the anterior cruciate ligament using semitendinosus tendon with Endobuttons: A preliminary report. presented at the 65th annual meeting of AAOS 1998.03.26 New Orleans

  135. 宗田　大，荻内隆司，柳下和慶，関矢一郎，山本晴康，四宮謙一. 前十字靭帯再建後3ヶ月の臨床像からみた術後2年の成績. 第33回日本膝関節研究会 1997.12.05 東京

  136. 宗田　大，高久田和夫，関矢一郎，山本晴康，四宮謙一. 皮下移植されたラットの膝蓋骨骨複合体の治癒過程に対する引っ張り刺激の影響. 第12回日本整形外科学会基礎学術集会 1997.10.17 新潟

  137. 宗田　大，荻内隆司，関矢一郎，栗原良暁，柳下和慶，山本晴康. 半腱様筋腱を多重折りで用いた2重束2ルート前十字靭帯再建術の短期成績. 第70回日本整形外科学会総会 1997.06.19 札幌

  138. 宗田　大、伊藤聰一郎、荻内隆司、関矢一郎、柳下和慶、山本晴康. 再建前十字靭帯の部位別にみた成熟過程の電子顕微鏡的検討. 第11回日本整形外科学会基礎学術集会 1996.10.18 鹿児島

  139. 宗田　大、荻内隆司、関矢一郎、山本晴康、古屋光太郎. 2重束の半腱様筋腱を2ルートで用いる前十字靭帯再建術. 第21回日本関節鏡学会 1995.12.03

  140. 宗田　大、山本晴康、荻内隆司、関矢一郎、古屋光太郎. 反復性膝蓋骨脱臼における脛骨粗面内側移行術後の成績不良例に対する内側膝蓋大腿靭帯再建術の経験. 第31回日本膝関節研究会 1995.12.02

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Patents 【 display / non-display 】

  • CELL REGION DETERMINATION METHOD, CELL IMAGING SYSTEM, AND CELL IMAGE PROCESSING APPARATUS

    Patent Number： 10482605

  • CELL REGION DETERMINATION METHOD, CELL IMAGING SYSTEM, AND CELL IMAGE PROCESSING APPARATUS

    Patent Number： CN ZL201611227796.X

  • CELL REGION DETERMINATION METHOD, CELL IMAGING SYSTEM, AND CELL IMAGE PROCESSING APPARATUS

    Patent Number： EP3188125

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Awards & Honors 【 display / non-display 】

  • Yusuke Nakagawa, Best Poster Presentation Award，Japanese Medical Society of America,Japan Society for the Promotion of Science，2017.04

  • Yusuke Nakagawa, Grant for Study Abroad by Mitsukoshi Health and Welfare Foundation，Mitsukoshi Health and Welfare Foundation，2016.08

  • Mitsuru Mizuno, Young Investigator Award，The Japanese Tissue Culture Association，2016.05

  • Koji Otabe, Excellence in Translational Science Award from Journal of Orthopaedic Research，Orthopaedic Research Society，2016.03

  • Ichiro Sekiya, The Japanese Society for Regenerative Medicine Award (Clinical Category)，The Japanese Society for Regenerative Medicine，2016.03

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