Personnel Information

写真a

ARAKAWA Satoko


Job title

Professor
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Degree 【 display / non-display 】

  • Doctor of Philosophy

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Campus Career 【 display / non-display 】

  • 2007.01
    -
    2015.12
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Assistant Professor
  • 2016.01
    -
    2021.02
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Junior Associate Professor
  • 2021.03
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    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Associate Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Core， Professor
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Research Areas 【 display / non-display 】

  • Morphology and anatomical structure

  • Cell biology

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Published Papers & Misc 【 display / non-display 】

  1. Sakurai HT, Arakawa S, Yamaguchi H, Torii S, Honda S, Shimizu S. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells. 2023.12; 12 (24): ( PubMed, DOI )

  2. Mehanna S, Arakawa S, Imasaka M, Chen W, Nakanishi Y, Nishiura H, Shimizu S, Ohmuraya M. Beclin1 is essential for the pancreas development. Developmental biology. 2023.09; 504 113-119. ( PubMed, DOI )

  3. Torii S, Arakawa S, Sato S, Ishikawa KI, Taniguchi D, Sakurai HT, Honda S, Hiraoka Y, Ono M, Akamatsu W, Hattori N, Shimizu S. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2. EMBO molecular medicine. 2023.08; 15 (9): e17451. ( PubMed, DOI )

  4. Kawahara R, Usami T, Arakawa S, Kamo H, Suzuki T, Komatsu R, Hara H, Niwa Y, Shimizu E, Dohmae N, Shimizu S, Simizu S. Biogenesis of fibrils requires C-mannosylation of PMEL. The FEBS journal. 2023.08; 290 (22): 5373-5394. ( PubMed, DOI )

  5. Kira A, Tatsutomi I, Saito K, Murata M, Hattori I, Kajita H, Muraki N, Oda Y, Satoh S, Tsukamoto Y, Kimura S, Onoue K, Yonemura S, Arakawa S, Kato H, Hirashima T, Kawane K. Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion. Developmental cell. 2023.07; 58 (14): 1282-1298.e7. ( PubMed, DOI )

  6. Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed, DOI )

  7. Iwamoto Tatsuya, Shimizu Shigeomi, Tajima-Sakurai Hajime, Yamaguchi Hirofumi, Nishida Yuya, Arakawa Satoko, Watada Hirotaka. Inhibition of Insulin Secretion Induces Golgi Morphological Changes 順天堂醫事雑誌. 2023.02; 69 (1): 42-49. ( ichushi )

  8. Sakurai HT, Arakawa S, Noguchi S, Shimizu S. FLIP-based autophagy-detecting technique reveals closed autophagic compartments. Scientific reports. 2022.12; 12 (1): 22452. ( PubMed, DOI )

  9. Matsuda H, Nibe-Shirakihara Y, Tamura A, Aonuma E, Arakawa S, Otsubo K, Nemoto Y, Nagaishi T, Tsuchiya K, Shimizu S, Ma A, Watanabe M, Uo M, Okamoto R, Oshima S. Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochemical and biophysical research communications. 2022.02; 592 74-80. ( PubMed, DOI )

  10. Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Human molecular genetics. 2021.02; 30 (6): 443-453. ( PubMed, DOI )

  11. Yamaguchi H, Honda S, Torii S, Shimizu K, Katoh K, Miyake K, Miyake N, Fujikake N, Sakurai HT, Arakawa S, Shimizu S. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nature communications. 2020.10; 11 (1): 5311. ( PubMed, DOI )

  12. Torii S, Yamaguchi H, Nakanishi A, Arakawa S, Honda S, Moriwaki K, Nakano H, Shimizu S. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy. Nature communications. 2020.04; 11 (1): 1754. ( PubMed, DOI )

  13. Honda S, Arakawa S, Yamaguchi H, Torii S, Tajima Sakurai H, Tsujioka M, Murohashi M, Shimizu S. Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases. Journal of molecular biology. 2020.04; 432 (8): 2622-2632. ( PubMed, DOI )

  14. Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life science alliance. 2020.03; 3 (3): ( PubMed, DOI )

  15. Kato Y, Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorganic & medicinal chemistry letters. 2019.12; 30 (3): 126891. ( PubMed, DOI )

  16. 清水 重臣, 山口 啓史, 桜井 一, 荒川 聡子. ゴルジ体の機能と構造(Molecular mechanisms and physiological roles of alternative autophagy) 日本生化学会大会プログラム・講演要旨集. 2019.09; 92回 [3S12m-05]. ( ichushi )

  17. Sugimoto Y, Murohashi M, Arakawa S, Honda S, Shimizu S. Prediction of intracellular targets of a small compound by analyzing peptides presented on MHC class I. Biochemical and biophysical research communications. 2019.01; 508 (2): 480-486. ( PubMed, DOI )

  18. Nagata M, Arakawa S, Yamaguchi H, Torii S, Endo H, Tsujioka M, Honda S, Nishida Y, Konishi A, Shimizu S. Dram1 regulates DNA damage-induced alternative autophagy Cell Stress. 2018.03; 2 (3): 55-65. ( DOI )

  19. Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018.02; 11 (516): ( PubMed, DOI )

  20. Medzhidov Nazim, Takata Toshitaro, Suzuki Mitsuhiro, Ichinose Shizuko, Yamaguchi Hirofumi, Arakawa Satoko, Shimizu Shigeomi, Tsubata Takeshi. B cell development and function Role of poor B cell receptor ubiquitination in efficient antigen presentation 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E. ( ichushi )

  21. Satoshi Yotsumoto, Yuito Muroi, Tatsuya Chiba, Rio Ohmura, Maki Yoneyama, Megumi Magarisawa, Kosuke Dodo, Naoki Terayama, Mikiko Sodeoka, Ryohei Aoyagi, Makoto Arita, Satoko Arakawa, Shigeomi Shimizu, Masato Tanaka. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep. 2017.11; 7 (1): 16026. ( PubMed, DOI )

  22. Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi, Shigeomi Shimizu. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci.. 2017.06; 93 (6): 378-385. ( PubMed, DOI )

  23. Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimizu. Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell Death Differ.. 2017.06; 24 (9): 1598-1608. ( PubMed, DOI )

  24. Arakawa Satoko, Honda Shinya, Yamaguchi Hirofumi, Shimizu Shigeomi. Atg5/Atg7非依存的代替オートファジーの分子機序と生理的役割(Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy) Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 2017.06; 93 (6): 378-384. ( ichushi )

  25. Satoko Arakawa, Shinya Honda, Satoru Torii, Masatsune Tsujioka, Shigeomi Shimizu. Monitoring of Atg5-Independent Mitophagy. Methods Mol. Biol.. 2017.04; 1759 125-132. ( PubMed, DOI )

  26. Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 2016.11; 7 13508. ( PubMed, DOI )

  27. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, Shigeomi Shimizu. Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Rep.. 2016.11; 17 (11): 1552-1564. ( PubMed, DOI )

  28. Hirofumi Yamaguchi, Satoko Arakawa, Toku Kanaseki, Takeshi Miyatsuka, Yoshio Fujitani, Hirotaka Watada, Yoshihide Tsujimoto, Shigeomi Shimizu. Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J.. 2016.09; 35 (18): 1991-2007. ( PubMed, DOI )

  29. Yusuke Nasu, Alexander Benke, Satoko Arakawa, Go J Yoshida, Genki Kawamura, Suliana Manley, Shigeomi Shimizu, Takeaki Ozawa. In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Sci Rep. 2016.06; 6 27505. ( PubMed, DOI )

  30. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2016.05; 533 (7601): 130. ( PubMed, DOI )

  31. Satoko Arakawa, Ikuko Nakanomyo, Yoko Kudo-Sakamoto, Hiroshi Akazawa, Issei Komuro, Shigeomi Shimizu. Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. Biochem. Biophys. Res. Commun.. 2015.11; 467 (4): 1006-1011. ( PubMed, DOI )

  32. Shinya Honda, Satoko Arakawa, Yuya Nishida, Hirofumi Yamaguchi, Eiichi Ishii, Shigeomi Shimizu. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nat Commun. 2014.06; 5 4004. ( PubMed, DOI )

  33. Shimizu S, Honda S, Arakawa S, Yamaguchi H. Alternative macroautophagy and mitophagy. Int J Biochem Cell Biol. 2014.05; 50 64-66. ( PubMed, DOI )

  34. Shimizu S, Yoshida T, Tsujioka M, Arakawa S. Autophagic cell death and cancer. Int J Mol Sci. 2014.02; 15 (2): 3145-3153. ( PubMed, DOI )

  35. Shimizu, S; Arakawa, S; Nishida, Y; Yamaguchi, H; Yoshida, T. Mammalian Autophagy Can Occur Through an Atg5/Atg7 Independent Pathway AUTOPHAGY: CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY, INFECTION, AND AGING, VOL 2: ROLE IN GENERAL DISEASES. 2014; 49-58. ( DOI )

  36. Mizushima T, Arakawa S, Sanada Y, Yoshino I, Miyazaki D, Urushima H, Tsujimoto Y, Ito T, Shimizu S. Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice. Am J Pathol. 2013.12; 183 (6): 1936-1944. ( PubMed, DOI )

  37. Nakase I, Okumura S, Katayama S, Hirose H, Pujals S, Yamaguchi H, Arakawa S, Shimizu S, Futaki S. Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine. Chem Commun (Camb). 2012.10; 48 (90): 11097-11099. ( PubMed, DOI )

  38. Miyaoka Y, Ebato K, Kato H, Arakawa S, Shimizu S, Miyajima A. Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Curr Biol. 2012.07; 22 (13): 1166-1175. ( PubMed, DOI )

  39. Konishi A, Arakawa S, Yue Z, Shimizu S. Involvement of beclin 1 in engulfment of apoptotic cells. J Biol Chem. 2012.04; 287 (17): 13919-13929. ( PubMed, DOI )

  40. Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C. Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe. 2012.04; 11 (4): 325-336. ( PubMed, DOI )

  41. Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H. Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 2011.11; 31 (46): 16872-16883. ( PubMed, DOI )

  42. Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science. 2011.05; 332 (6032): 966-970. ( PubMed, DOI )

  43. Kamiya K, Tsumoto K, Arakawa S, Shimizu S, Morita I, Yoshimura T, Akiyoshi K. Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method. Biotechnol Bioeng. 2010.12; 107 (5): 836-843. ( PubMed, DOI )

  44. Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S, Yoshida H, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci U S A. 2010.04; 107 (14): 6436-6441. ( PubMed, DOI )

  45. Shimizu S, Arakawa S, Nishida Y. Autophagy takes an alternative pathway. Autophagy. 2010.02; 6 (2): 290-291. ( PubMed, DOI )

  46. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2009.10; 461 (7264): 654-658. ( PubMed, DOI )

  47. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavare S, Arakawa S, Shimizu S, Watt FM, Narita M. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009.04; 23 (7): 798-803. ( PubMed, DOI )

  48. Sato Asako, Sasaoka Toshikuni, Arakawa Satoko, Morita Tomoko, Katsuki Kuniko, Katsuki Motoya. Analysis of locomotor control using transgenic mice having controllable D1R expression NEUROSCIENCE RESEARCH. 2009; 65 S77-S78. ( DOI )

  49. Sasaoka Toshikuni, Sato Asako, Arakawa-Kobayashi Satoko, Morita Tomoko, Katsuki Kuniko, Katsuki Motoya. Analysis of motor control using D1R/D2R double knockout mice NEUROSCIENCE RESEARCH. 2008; 61 S222.

  50. Goh T, Uchida W, Arakawa S, Ito E, Dainobu T, Ebine K, Takeuchi M, Sato K, Ueda T, Nakano A. VPS9a, the common activator for two distinct types of Rab5 GTPases, is essential for the development of Arabidopsis thaliana. Plant Cell. 2007.11; 19 (11): 3504-3515. ( PubMed, DOI )

  51. Panichkin VB, Arakawa-Kobayashi S, Kanaseki T, Suzuki I, Los DA, Shestakov SV, Murata N. Serine/threonine protein kinase SpkA in Synechocystis sp. strain PCC 6803 is a regulator of expression of three putative pilA operons, formation of thick pili, and cell motility. J Bacteriol. 2006.11; 188 (21): 7696-7699. ( PubMed, DOI )

  52. Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004.12; 6 (12): 1221-1228. ( PubMed, DOI )

  53. Arakawa-Kobayashi S, Kanaseki T. A study of lipid secretion from the lichen symbionts, ascomycetous fungus Myelochroa leucotyliza and green alga Trebouxia sp. J Struct Biol. 2004.06; 146 (3): 401-415. ( PubMed, DOI )

  54. Arakawa-Kobayashi S, Kobayashi T, Hasebe M, Kanaseki T. Identification of crystalline material found in the thallus of the lichen, Myelochroa leucotyliza. J Struct Biol. 2004.06; 146 (3): 393-400. ( PubMed, DOI )

  55. Hashimoto S, Murakami M, Kanaseki T, Kobayashi S, Matsuki M, Shimono M, Segawa A. Morphological and functional changes in cell junctions during secretory stimulation in the perfused rat submandibular gland. Eur J Morphol. 2003.02; 41 (1): 35-39. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu. The role of acrosome and nuclear pore on the changes of physical properties and nuclear morphology of sperm chromatin. A Genome modality Understanding physical properties of the genome, Meeting, 2022.11.22 Zoom

  2. Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu. Discovery of Alternative Autophagy and its Physiological Role in the Brain. 日本顕微鏡学会第78回学術講演会 2022.05.12

  3. Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu. Wipi3 is essential for Golgi membrane-associated degradation (GOMED) pathway and its loss causes neurodegeneration. 第44回分子生物学会年会 2021.12.03 横浜

  4. Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu. The role of acrosome and nuclear pore on the changes of physical properties and nuclear morphology of sperm chromatin. A Genome modality Understanding physical properties of the genome 2021.11.05

  5. Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi, Shigeomi Shimizu. The membrane origin of mitophagy after enucleation in red blood cell. International Symposium for Female Researchers in Chromatin Biology (ISFRCB) 2020 2020.12.05

  6. 清水 重臣, 山口 啓史, 桜井 一, 荒川 聡子. ゴルジ体の機能と構造　オルタナティブオートファジーの分子機構と生理的役割(Molecular mechanisms and physiological roles of alternative autophagy). 日本生化学会大会プログラム・講演要旨集 2019.09.01

  7. Satoko Arakawa, Shinya Honda, Shigeomi Shimizu. Electron microscopic analysis of mitophagy during erythrocyte maturation. Joint Annual Meeting of 71st JSCB & 19th PSSJ 2019.06.25 Kobe

  8. 清水 重臣, 成田 匡司, 荒川 聡子. がんと細胞老化シグナル　オートファジーと細胞老化の関連(Cancer and cellular senescence signaling　Relationship between autophagy and cellular senescence Relationship between autophagy and cellular senescence). 日本癌学会総会記事 2018.09.01

  9. 荒川聡子、山口啓史、清水重臣. 細胞機能を司るオルガネラ・ゾーンの解読 ゴルジ体を介したタンパク質分解システムの発見. 生命科学系学会合同年次大会(ConBio2017)(第40回日本分子生物学会） 2017.12.06

  10. Medzhidov Nazim, Takata Toshitaro, Suzuki Mitsuhiro, Ichinose Shizuko, Yamaguchi Hirofumi, Arakawa Satoko, Shimizu Shigeomi, Tsubata Takeshi. B細胞の発生と機能　効率的な抗原提示においてB細胞受容体の低ユビキチン化が果たす役割(B cell development and function　Role of poor B cell receptor ubiquitination in efficient antigen presentation). 日本免疫学会総会・学術集会記録 2017.12.01

  11. 荒川聡子, 山口啓史, 金関悳, 清水重臣. Discovery of Atg5-independent alternative macroautophagy in yeast and its morphological analysis. 日本分子生物学会年会 2012.12.11 福岡　福岡国際会議場

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Others 【 display / non-display 】

  • Taking out the trash is essential for brain health，2020.11

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Campus class subject 【 display / non-display 】

  • Utilizing Research Core Facilities and Introduction to Installed Equipment，2024

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