Personnel Information

写真a

OKAMOTO Ryuichi


Job title

Professor

Birth date

1972

Mail Address

rokamoto.gast@tmd.ac.jp

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1996, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2004.03, Completed

Degree 【 display / non-display

  • Doctor of philosophy in medical science, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2018.04
    -
    2020.05
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Professor
  • 2007.04
    -
    2014.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Advanced Therapeutics for GI Diseases, Associate Professor
  • 2014.04
    -
    2014.09
    Tokyo Medical and Dental University, Center for Stem Cell and Regenerative Medicine, Project Professor
  • 2014.10
    -
    2017.03
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Center for Stem Cell and Regenerative Medicine, Professor
  • 2017.04
     
     
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Professor

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External Career 【 display / non-display

  • 2014.10
    -
    Now
    , Professor

Research Areas 【 display / non-display

  • Gastroenterology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  • Taku Sato, Shun Ishikawa, Jumpei Asano, Hirona Yamamoto, Masayuki Fujii, Toshiro Sato, Kouhei Yamamoto, Keisuke Kitagaki, Takumi Akashi, Ryuichi Okamoto, Toshiaki Ohteki. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. 2020.08; 22 (8): 919-926. ( PubMed, DOI )

  • Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Lett. 2020.05; 594 (10): 1586-1595. ( PubMed, DOI )

  • Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem Biophys Res Commun. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  • Yuria Takei, Yasuhiro Nemoto, Ryo Morikawa, Shohei Tanaka, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 328-335. ( PubMed, DOI )

  • Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver(Canada)

  • Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Sho Watanabe, Nobuhiro Katsukura, Tomoaki Shirasaki, Ryuichi Okamoto, Mamoru Watanabe. Establishment of chronic inflammation model using human small intestinal and colonic organoids. UEG Week 2019 2019.10.23 Fira Gran Via, Barcelona, Spain

  • Okamoto R, Watanabe M. 【Focus Session: Cutting Edge Regenerative Medicine Using Stem Cells】Intestinal Epithelial Stem Cell Organoids and IBD. ISSCR2019 2019.06.26 Los Angeles(USA)

  • Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. The 7th annual meeting of AOCC 2019.06.15 Taipei, Taiwan

  • Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M. Functional analysis of isoflavones using patient-derived intestinal organoids. AOCC2019 2019.06.14 Taipei(Taiwan)

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