Personnel Information

写真a

ITO Nobutoshi


Job title

Professor

Birth date

1963

Laboratory Address

M&D Tower 22F, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4594

Laboratory Fax number

+81-3-5803-4594

Mail Address

ito.str@tmd.ac.jp

Research Areas, Keywords

Structural biology, X-ray crystallography, Protein Data Bank
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Engineering, 1986.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Engineering, Master's Course, 1988.03, Completed

  • The University of Leeds, Department of Biochemistry & Molecular Biology, Doctor's Course, 1991.08, Completed

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Degree 【 display / non-display 】

  • Ph D, The University of Leeds

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Campus Career 【 display / non-display 】

  • 2012.04
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Structural Biology， Professor
  • 2012.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Structural Biology， Professor
  • 2003.04
    -
    2012.03
    Tokyo Medical and Dental University， Biomedical Science PhD Program / Graduate School of Biomedical Science， Professor
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External Career 【 display / non-display 】

  • 1991.08
    -
    1992.06
    The University of Leeds, Dept of Biochem. & Mol. Biol., Research Fellow
  • 1992.07
    -
    1994.11
    MRC Laboratory of Molecular Biology, Scientific Staff
  • 1994.12
    -
    1996.05
    The University of Leeds, Dept of Biochem. & Mol. Biol., Research Fellow
  • 1996.06
    -
    2001.07
    Biomolecular Engineering Research Institute,
  • 2001.08
    -
    2003.03
    Japan Science and Technology Agency,
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Academic Society Affiliations 【 display / non-display 】

  • The Biophysical Society of Japan

  • Japanese Society for Chemical Biology

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Research Areas 【 display / non-display 】

  • Structural biochemistry

  • Biophysics

  • Chemical biology

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Published Papers & Misc 【 display / non-display 】

  • Alborzian Deh Sheikh A, Gomaa S, Li X, Routledge M, Saigoh K, Numoto N, Angata T, Hitomi Y, Takematsu H, Tsuiji M, Ito N, Kusunoki S, Tsubata T. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Journal of autoimmunity. 2021.01; 116 102571. ( PubMed, DOI )

  • Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H, Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A. Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. Journal of medicinal chemistry. 2020.12; ( PubMed, DOI )

  • Emori Miho, Numoto Nobutaka, Senga Akane, Bekker Gert-Jan, Kamiya Narutoshi, Kobayashi Yuma, Ito Nobutoshi, Kawai Fusako, Oda Masayuki. Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2020.12; ( PubMed, DOI )

  • Iiyama M, Numoto N, Ogawa S, Kuroda M, Morii H, Abe R, Ito N, Oda M. Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Molecular immunology. 2020.12; ( PubMed, DOI )

  • Senga A, Numoto N, Yamashita M, Iida A, Ito N, Kawai F, Oda M. Multiple structural states of Ca2+ regulated PET hydrolase, Cut190, and its correlation with activity and stability. Journal of biochemistry. 2020.09; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  • Nobutoshi Ito. PDBx/mmCIF format for crystallographic deposition to the Protein Data Bank (PDB). Annual Meeting of The Federation of Korean Societies for Molecular & Biomedical Sciences (FKSBS) 2020.01.10 Gwangju, South Korea

  • Teikichi Ikura, Nobutoshi Ito. Micronization of a protease derived from Pin1. The 57th annual meeting of the Biophysical Society of Japan 2019.09.25

  • Shotaro Yasukochi, Nobutaka Numoto, Kiminori Hori, Natsuko Tenno, Takeshi Tenno, Nobutoshi Ito, Hidekazu Hiroaki. Crystal structure of human Dishevelled1 PDZ with its inhibitor. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Nobutaka Numoto, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Akihiro Nishiguchi, Nobutaka Numoto, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Antigen recognition mechanism of an affinity-matured single chain Fv antibody against anti-(4-hydroxy-3-nitrophenyl)acetyl. The 92nd Annual Meeting of the Japanese Biochemical Society 2019.09.18 Yokohama

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Campus class subject 【 display / non-display 】

  • Philosophy of Medicine and Dentistry，2012 - Now

  • Special Lecture on Molecular Structure，2009 - Now

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