Personnel Information

写真a

ITO Nobutoshi


Job title

Professor

Birth date

1963

Laboratory Address

M&D Tower 22F, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4594

Laboratory Fax number

+81-3-5803-4594

Mail Address

ito.str@tmd.ac.jp

Research Areas, Keywords

Structural biology, X-ray crystallography, Protein Data Bank
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Engineering, 1986.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Engineering, Master's Course, 1988.03, Completed

  • The University of Leeds, Department of Biochemistry & Molecular Biology, Doctor's Course, 1991.08, Completed

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Degree 【 display / non-display 】

  • Ph D, The University of Leeds

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Campus Career 【 display / non-display 】

  • 2012.04
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Structural Biology， Professor
  • 2012.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Structural Biology， Professor
  • 2003.04
    -
    2012.03
    Tokyo Medical and Dental University， Biomedical Science PhD Program / Graduate School of Biomedical Science， Professor
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External Career 【 display / non-display 】

  • 1991.08
    -
    1992.06
    The University of Leeds, Dept of Biochem. & Mol. Biol., Research Fellow
  • 1992.07
    -
    1994.11
    MRC Laboratory of Molecular Biology, Scientific Staff
  • 1994.12
    -
    1996.05
    The University of Leeds, Dept of Biochem. & Mol. Biol., Research Fellow
  • 1996.06
    -
    2001.07
    Biomolecular Engineering Research Institute,
  • 2001.08
    -
    2003.03
    Japan Science and Technology Agency,
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Academic Society Affiliations 【 display / non-display 】

  • The Biophysical Society of Japan

  • Japanese Society for Chemical Biology

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Research Areas 【 display / non-display 】

  • Structural biochemistry

  • Biophysics

  • Chemical biology

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Published Papers & Misc 【 display / non-display 】

  • Nishiguchi A, Numoto N, Ito N, Azuma T, Oda M. Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain. Molecular immunology. 2019.10; 114 545-552. ( PubMed, DOI )

  • Masuno Hiroyuki, Kazui Yuko, Tanatani Aya, Fujii Shinya, Kawachi Emiko, Ikura Teikichi, Ito Nobutoshi, Yamamoto Keiko, Kagechika Hiroyuki. Development of novel lithocholic acid derivatives as vitamin D receptor agonists BIOORGANIC & MEDICINAL CHEMISTRY. 2019.08; 27 (16): 3674-3681. ( PubMed, DOI )

  • Yasukochi Shotaro, Numoto Nobutaka, Hori Kiminori, Tenno Natsuko, Tenno Takeshi, Ito Nobutoshi, Hiroaki Hidekazu. ヒトDishevelled1 PDZドメインと阻害剤の共結晶構造解析(Crystal structure of human Dishevelled1 PDZ with its inhibitor) 生物物理. 2019.08; 59 (Suppl.1-2): S240. ( ichushi )

  • Numoto Nobutaka, Fukumori Yoshihiro, Miki Kunio, Ito Nobutoshi. 巨大ヘモグロビンのアロステリック中間体の時分割構造解析(Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin) 生物物理. 2019.08; 59 (Suppl.1-2): S245. ( ichushi )

  • Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto SE, Li Y, Yoshino H, Mogushi K, Hatano T, Sato T, Ikura T, Ito N, Motoi Y, Hattori N. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. Neurobiology of aging. 2019.03; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  • Teikichi Ikura, Nobutoshi Ito. Micronization of a protease derived from Pin1. The 57th annual meeting of the Biophysical Society of Japan 2019.09.25

  • Shotaro Yasukochi, Nobutaka Numoto, Kiminori Hori, Natsuko Tenno, Takeshi Tenno, Nobutoshi Ito, Hidekazu Hiroaki. Crystal structure of human Dishevelled1 PDZ with its inhibitor. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Nobutaka Numoto, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Akihiro Nishiguchi, Nobutaka Numoto, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Antigen recognition mechanism of an affinity-matured single chain Fv antibody against anti-(4-hydroxy-3-nitrophenyl)acetyl. The 92nd Annual Meeting of the Japanese Biochemical Society 2019.09.18 Yokohama

  • Teikichi Ikura, Yasushige Yonezawa and Nobutoshi Ito. A single mutation C113A caused drastic change in the dynamic of Pin1. Joint Annual Meeting of 71st JSCB & 19th PSSJ 2019.06.25 Kobe City

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Campus class subject 【 display / non-display 】

  • Philosophy of Medicine and Dentistry，2012 - Now

  • Special Lecture on Molecular Structure，2009 - Now

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