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YAMAMOTO Kouhei
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Graduating School 【 display / non-display 】
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Tokyo Medical and Dental University, Faculty of Medicine, 2003.03, Graduated
Graduate School 【 display / non-display 】
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Tokyo Medical and Dental University, Doctor's Course, 2007.03, Completed
Campus Career 【 display / non-display 】
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2007.04-2018.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Comprehensive Pathology, Assistant Professor
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2018.04-2022.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Comprehensive Pathology, Assistant Professor
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2022.04-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Systemic Organ Regulation, Department of Human Pathology, Junior Associate Professor
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2022.10-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Human Pathology, Junior Associate Professor
External Career 【 display / non-display 】
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2010.10-2011.08Memorial Sloan-Kettering Cnacer Center, Human Oncology and Pathogenesis Program, Post doctral fellow
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2011.09-2013.09Memorial Sloan-Kettering Cnacer Center, Biomedical Sciences, Visiting Scientist
Research Areas 【 display / non-display 】
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Human pathology
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Experimental pathology
Published Papers & Misc 【 display / non-display 】
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Kawade G, Kurata M, Matsuki Y, Fukuda S, Onishi I, Kinowaki Y, Watabe S, Ishibashi S, Ikeda M, Yamamoto M, Ohashi K, Kitagawa M, Yamamoto K. Mediation of FSP1 expression via 4-HNE accumulation contributes to acquisition of resistance to apoptosis and ferroptosis in DLBCL. Laboratory investigation; a journal of technical methods and pathology. 2024.02; 102027. ( PubMed, DOI )
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Morimoto M, Nawa N, Okada E, Itsui Y, Kashimada A, Yamamoto K, Akaishi Y, Yamawaki M. Elucidation of the needs for telecritical care services in Japan: a qualitative study. BMJ open. 2023.11; 13 (11): e072065. ( PubMed, DOI )
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Hashimoto J, Oh Y, Yamamoto K, Yoshii T, Fukushima K, Kitagawa M, Okawa A. Frequency and pathogenesis of periprosthetic atypical femoral fractures associated with total knee arthroplasty: A multicenter prospective study with complementary histopathological and biomechanical analysis. Injury. 2023.10; 111136. ( PubMed, DOI )
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Watabe S, Aruga Y, Kato R, Kawade G, Kubo Y, Tatsuzawa A, Onishi I, Kinowaki Y, Ishibashi S, Ikeda M, Fukawa Y, Akahoshi K, Tanabe M, Kurata M, Ohashi K, Kitagawa M, Yamamoto K. Regulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma. Biomedicines. 2023.08; 11 (8): ( PubMed, DOI )
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Sugita K, Onishi I, Nakayama R, Ishibashi S, Ikeda M, Inoue M, Narita R, Oshima S, Shimizu K, Saito S, Sato S, Moriarity BS, Yamamoto K, Largaespada DA, Kitagawa M, Kurata M. Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions. Communications biology. 2023.06; 6 (1): 582. ( PubMed, DOI )
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Kato Yuki, Ito Takashi, Yamamoto Kouhei, Furukawa Asuka, Shintaku Hiroshi, Yamamoto Kurara, Sakai Momoka, Tomita Yoshinobu, Chino Yusuke, Uchida Keisuke, Kawada Kenro, Ohashi Kenichi. Invasive features of superficial oesophageal squamous cell carcinoma-analysis of risk factors for lymph node metastasis VIRCHOWS ARCHIV. 2023.06; 483 (5): 645-653. ( PubMed, DOI )
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Tanaka Keisuke, Ichikawa Ayako, Umezawa Natsuka, Yamamoto Kouhei, Yoshifuji Kota, Okada Keigo, Nogami Ayako, Umezawa Yoshihiro, Nagao Toshikage, Sakashita Chizuko, Mori Takehiko, Tohda Shuji, Koike Ryuji, Yasuda Shinsuke, Yamamoto Masahide. Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis CANCER SCIENCE. 2023.06; 114 (9): 3719-3727. ( PubMed, DOI )
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Hirai T, Yoshii T, Inose H, Matsukura Y, Funauchi Y, Egawa S, Utagawa K, Hashimoto J, Nishizawa M, Yamamoto K, Okawa A. Intraosseous Aggressive Schwannoma in the Lumbar Spine: A Case Report. Spine surgery and related research. 2023.05; 7 (3): 288-292. ( PubMed, DOI )
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Matsushita Y, Liu J, Chu AKY, Tsutsumi-Arai C, Nagata M, Arai Y, Ono W, Yamamoto K, Saunders TL, Welch JD, Ono N. Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nature communications. 2023.04; 14 (1): 2383. ( PubMed, DOI )
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Unuma Kana, Tomomasa Dan, Noma Kosuke, Yamamoto Kouhei, Matsuyama Taka-aki, Makino Yohsuke, Hijikata Atsushi, Wen Shuheng, Ogata Tsutomu, Okamoto Nobuhiko, Okada Satoshi, Ohashi Kenichi, Uemura Koichi, Kanegane Hirokazu. Case Report: Molecular autopsy underlie COVID-19-associated sudden, unexplained child mortality FRONTIERS IN IMMUNOLOGY. 2023.04; 14 1121059. ( PubMed, DOI )
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Koide T, Mandai S, Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Yokota T, Uchida S. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circulation research. 2023.02; 132 (4): 415-431. ( PubMed, DOI )
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Tzavlaki K, Ohata Y, Morén A, Watanabe Y, Eriksson J, Tsuchiya M, Kubo Y, Yamamoto K, Sellin ME, Kato M, Caja L, Heldin CH, Moustakas A. The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition. Journal of cellular physiology. 2023.02; ( PubMed, DOI )
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Tanaka H., Fukawa Y., Yamamoto K., Tanimoto K., Takemoto A., Hasumi H., Hirakawa A., Ishikawa Y., Fukuda S., Waseda Y., Yoshida S., Yokoyama M., Campbell S. C., Fujii Y.. Renal parenchymal infiltration or micronodular spread in non-metastatic clear cell renal cell carcinoma: Prognostic impact and genomic backgrounds EUROPEAN UROLOGY. 2023.02; 83 S668-S669.
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Tanaka H, Fukuda S, Kimura K, Fukawa Y, Yamamoto K, Fukushima H, Moriyama S, Yasuda Y, Uehara S, Waseda Y, Yoshida S, Yokoyama M, Matsuoka Y, Saito K, Tateishi U, Campbell SC, Fujii Y. Defining Tumour Shape Irregularity for Preoperative Risk Stratification of Clinically Localised Renal Cell Carcinoma. European urology open science. 2023.02; 48 36-43. ( PubMed, DOI )
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Nagao T, Yoshifuji K, Sadato D, Motomura Y, Saito M, Yamamoto K, Yamamoto K, Nogami A. Establishment and characterization of a new activated B-cell-like DLBCL cell line, TMD12. Experimental hematology. 2022.12; 116 37-49. ( PubMed, DOI )
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Kurata Morito, Antony Marie Lue, Noble-Orcutt Klara E., Rathe Susan K., Lee Yoonkyu, Furuno Hidehiro, Ishibashi Sachiko, Ikeda Masumi, Yamamoto Kouhei, Kitagawa Masanobu, Largaespada David A., Sachs Zohar. Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line MOLECULAR CANCER RESEARCH. 2022.11; 20 (11): 1646-1658. ( PubMed, DOI )
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Tatsumi Akiya, Hirakochi Haruka, Inoue Satomi, Tanaka Yosuke, Furuno Hidehiro, Ikeda Masumi, Ishibashi Sachiko, Taguchi Towako, Yamamoto Kouhei, Onishi Iichiroh, Sachs Zohar, Largaespada David A., Kitagawa Masanobu, Kurata Morito. Identification of NRAS Downstream Genes with CRISPR Activation Screening BIOLOGY-BASEL. 2022.11; 11 (11): ( PubMed, DOI )
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Koyanagi Anri, Onishi Iichiroh, Muraoka Karin, Sato Ikue, Sato Shingo, Kimura Tsuyoshi, Kishida Akio, Yamamoto Kouhei, Kitagawa Masanobu, Kurata Morito. Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone BIOENGINEERING-BASEL. 2022.10; 9 (10): ( PubMed, DOI )
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Hayashi Kumiko, Nogawa Daichi, Kobayashi Maki, Asakawa Ayaka, Ohata Yae, Kitagawa Shota, Kubota Kazuishi, Takahashi Hisashi, Yamada Miyuki, Oda Goshi, Nakagawa Tsuyoshi, Uetake Hiroyuki, Onishi Iichiroh, Kinowaki Yuko, Kurata Morito, Kitagawa Masanobu, Yamamoto Kouhei. Quantitative high-throughput analysis of tumor infiltrating lymphocytes in breast cancer FRONTIERS IN ONCOLOGY. 2022.09; 12 901591. ( PubMed, DOI )
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Asakawa A, Kawade G, Kurata M, Fukuda S, Onishi I, Kinowaki Y, Ishibashi S, Ikeda M, Watabe S, Kobayashi M, Ishibashi H, Okubo K, Kitagawa M, Yamamoto K. Stratification of lung squamous cell carcinoma based on ferroptosis regulators: Potential for new therapeutic strategies involving ferroptosis induction. Lung cancer (Amsterdam, Netherlands). 2022.01; 165 82-90. ( PubMed, DOI )
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Miyamoto R, Hirai T, Yoshii T, Onuma H, Inose H, Yuasa M, Matsukura Y, Morishita S, Yamamoto K, Koyanagi H, Sato S, Yagishita K, Okawa A. Surgical Strategy for Osteoid Osteoma Localized in Anterior Lumbar Vertebral Body: A Case Report. Spine surgery and related research. 2022; 6 (4): 408-411. ( PubMed, DOI )
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Ishisaka Y, Nosaka N, Mishima Y, Masuda T, Nagashima M, Tanaka Y, Yamamoto K, Yoshida M, Shigemitsu H. COVID-19 case of ventilator-induced lung injury on extracorporeal membrane oxygenation: Physicians' clinical struggle and ethical conflict in a novel pandemic. Clinical case reports. 2021.12; 9 (12): e05223. ( PubMed, DOI )
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Kinowaki Yuko, Taguchi Towako, Onishi Iichiroh, Kirimura Susumu, Kitagawa Masanobu, Yamamoto Kouhei. Overview of Ferroptosis and Synthetic Lethality Strategies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.09; 22 (17): ( PubMed, DOI )
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Sekine Y, Yamamoto K, Kurata M, Honda A, Onishi I, Kinowaki Y, Kawade G, Watabe S, Nomura S, Fukuda S, Ishibashi S, Ikeda M, Yamamoto M, Kitagawa M. HADHB, a fatty acid beta-oxidation enzyme, is a potential prognostic predictor in malignant lymphoma. Pathology. 2021.09; 54 (3): 286-293. ( PubMed, DOI )
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Shimada W, Tanaka H, Fukawa Y, Kimura K, Yamamoto K, Fukuda S, Fukushima H, Yasuda Y, Uehara S, Yoshida S, Yokoyama M, Matsuoka Y, Tateishi U, Campbell SC, Fujii Y. Infiltrative tumor interface with normal renal parenchyma in locally advanced renal cell carcinoma: Clinical relevance and pathological implications. International journal of urology : official journal of the Japanese Urological Association. 2021.08; 28 (12): 1233-1239. ( PubMed, DOI )
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Nakatsutsumi K, Morishita K, Yagi M, Doki S, Watanabe A, Ikegami N, Kobayashi T, Kojima M, Senda A, Yamamoto K, Aiboshi J, Coimbra R, Otomo Y. Vagus nerve stimulation modulates arachidonic acid production in the mesenteric lymph following intestinal ischemia-reperfusion injury. The journal of trauma and acute care surgery. 2021.07; ( PubMed, DOI )
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Unuma Kana, Makino Yohsuke, Yamamoto Kouhei, Hattori Shinya, Arai Nobutaka, Sakai Kentaro, Kitagawa Masanobu, Uemura Koichi, Kanegane Hirokazu. Fatal intracranial hemorrhage due to infantile acute lymphoblastic leukemia mimicking abusive head trauma JOURNAL OF FORENSIC SCIENCES. 2021.07; 66 (6): 2504-2510. ( PubMed, DOI )
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Fujimaru T, Kawanishi K, Mori T, Mishima E, Sekine A, Chiga M, Mizui M, Sato N, Yanagita M, Ooki Y, Nagahama K, Ohnuki Y, Hamano N, Watanabe S, Mochizuki T, Nagatsuji K, Tanaka K, Tsukamoto T, Tsushima H, Shimamoto M, Tsuji T, Kuyama T, Kawamoto S, Maki K, Katsuma A, Oishi M, Yamamoto K, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Iimori S, Naito S, Rai T, Hoshino J, Ubara Y, Miyazaki M, Nagata M, Uchida S, Sohara E. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney international reports. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )
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Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2021.05; 25 (5): 445-455. ( PubMed, DOI )
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Fukawa Yuki, Sakamoto Kei, Kugimoto Takuma, Michi Yasuyuki, Harada Hiroyuki, Yamamoto Masahide, Kitagawa Masanobu, Ikeda Tohru, Yamamoto Kouhei. Nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate PATHOLOGY INTERNATIONAL. 2021.03; 71 (3): 213-215. ( PubMed, DOI )
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Sanjo Nobuo, Nose Yurie, Miyamoto Shouhei, Shishido-Hara Yukiko, Saito Tatsuya, Fukuda Tetsuya, Yamamoto Kurara, Kobayashi Daisuke, Yokota Takanori. Early Pathological JC Virus Lesions in a Patient without Any MRI-based Indications INTERNAL MEDICINE. 2021; 60 (8): 1279-1282. ( PubMed, DOI )
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Oh Y, Yamamoto K, Yoshii T, Kitagawa M, Okawa A. Current concept of stress fractures with an additional category of atypical fractures: a perspective review with representative images. Therapeutic advances in endocrinology and metabolism. 2021; 12 20420188211049619. ( PubMed, DOI )
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Nishimura T, Nakamura Y, Kinoshita N, Yamamoto K, Sasaki Y, Akiyoshi K. Biocatalytic Hybrid Films Self-Assembled from Carbohydrate Block Copolymers and Polysaccharides for Enzyme Prodrug Therapy. ACS applied bio materials. 2020.12; 3 (12): 8865-8871. ( PubMed, DOI )
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Yamamoto Akiko, Kurata Morito, Yamamoto Kohei, Nogawa Daichi, Inoue Miori, Ishibashi Sachiko, Ikeda Masumi, Miyasaka Naoyuki, Kitagawa Masanobu. High amplification of PVT1 and MYC predict favorable prognosis in early ovarian carcinoma PATHOLOGY RESEARCH AND PRACTICE. 2020.11; 216 (11): 153175. ( PubMed, DOI )
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Taguchi Towako, Kurata Morito, Onishi Iichiroh, Kinowako Yuko, Sato Yunosuke, Shiono Sayuri, Ishibashi Sachiko, Ikeda Masumi, Yamamoto Masahide, Kitagawa Masanobu, Yamamoto Kouhei. SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma LABORATORY INVESTIGATION. 2020.10; 101 (2): 218-227. ( PubMed, DOI )
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Inoue Maiko, Isoda Takeshi, Yamashita Motoi, Tomoda Takahiro, Inoue Kento, Okano Tsubasa, Ohkawa Teppei, Endo Akifumi, Mitsuiki Noriko, Kamiya Takahiro, Yanagimachi Masakatsu, Yamamoto Kouhei, Inaba Yuichiro, Sasaki Toru, Takagi Masatoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Cytomegalovirus Laryngitis in Primary Combined Immunodeficiency Diseases JOURNAL OF CLINICAL IMMUNOLOGY. 2020.10; 41 (1): 243-247. ( PubMed, DOI )
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Yokoyama Kota, Manabe Osamu, Tsuchiya Jyunichi, Oyama Jun, Kawabe Hiroaki, Tateishi Yumiko, Asakage Takahiro, Yamamoto Kouhei, Tateishi Ukihide. A rare case of cranial and spinal leptomeningeal dissemination of recurrent ethmoid carcinoma detected by [18F]-FDG PET/CT EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020.09; 48 (4): 1266-1267. ( PubMed, DOI )
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Yanai Masae, Kurata Morito, Muto Yutaka, Iha Hiroto, Kanao Toshinori, Tatsuzawa Anna, Ishibashi Sachiko, Ikeda Masumi, Kitagawa Masanobu, Yamamoto Kouhei. Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma PATHOLOGY. 2020.08; 52 (5): 529-537. ( PubMed, DOI )
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Oh Yoto, Yamamoto Kouhei, Hashimoto Jun, Fujita Koji, Yoshii Toshitaka, Fukushima Kazuyuki, Kurosa Yoshiro, Wakabayashi Yoshiaki, Kitagawa Masanobu, Okawa Atsushi. Biological activity is not suppressed in mid-shaft stress fracture of the bowed femoral shaft unlike in "typical" atypical subtrochanteric femoral fracture: A proposed theory of atypical femoral fracture subtypes BONE. 2020.08; 137 115453. ( PubMed, DOI )
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Kurata Morito, Antony Marie L., Noble Klara E., Rathe Susan K., Hirakouchi Haruka, Yamamoto Kouhei, Kitagawa Masanobu, Sachs Zohar, Largaespada David A.. Dose-dependent NRAS(G12V)-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line CANCER RESEARCH. 2020.08; 80 (16): ( DOI )
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Kaneko Kasumi, Yoshida Soichiro, Yamamoto Kouhei, Arita Yuki, Kijima Toshiki, Yokoyama Minato, Ishioka Junichiro, Matsuoka Yoh, Saito Kazutaka, Fujii Yasuhisa. Renal epithelioid angiomyolipoma: Incidence in a Japanese cohort and diagnostic utility of diffusion-weighted magnetic resonance imaging INTERNATIONAL JOURNAL OF UROLOGY. 2020.07; 27 (7): 599-604. ( PubMed, DOI )
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Sato Taku, Ishikawa Shun, Asano Jumpei, Yamamoto Hirona, Fujii Masayuki, Sato Toshiro, Yamamoto Kouhei, Kitagaki Keisuke, Akashi Takumi, Okamoto Ryuichi, Ohteki Toshiaki. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages NATURE CELL BIOLOGY. 2020.07; 22 (8): 919-926. ( PubMed, DOI )
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Yamamoto Akiko, Kurata Morito, Onishi Iichiroh, Sugita Keisuke, Matsumura Miwa, Ishibashi Sachiko, Ikeda Masumi, Yamamoto Kouhei, Kitagawa Masanobu. CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system PEERJ. 2020.05; 8 e9046. ( PubMed, DOI )
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Furusho Taisuke, Sohara Eisei, Mandai Shintaro, Kikuchi Hiroaki, Takahashi Naohiro, Fujimaru Takuya, Hashimoto Hiroko, Arai Yohei, Ando Fumiaki, Zeniya Moko, Mori Takayasu, Susa Koichiro, Isobe Kiyoshi, Nomura Naohiro, Yamamoto Kohei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Renal TNF alpha activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease KIDNEY INTERNATIONAL. 2020.04; 97 (4): 713-727. ( PubMed, DOI )
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Yamamoto K, Abe S, Honda A, Hashimoto J, Aizawa Y, Ishibashi S, Takemura T, Hanagata N, Yamamoto M, Miura O, Kurata M, Kitagawa M. Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma. Laboratory investigation; a journal of technical methods and pathology. 2020.03; 100 (3): 353-362. ( PubMed, DOI )
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Arai Ayako, Takase Hiroshi, Yoshimori Mayumi, Yamamoto Kouhei, Mochizuki Manabu, Miura Osamu. Gene expression profiling of primary vitreoretinal lymphoma CANCER SCIENCE. 2020.03; 111 (4): 1417-1421. ( PubMed, DOI )
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Kitagawa Masanobu, Kurata Morito, Onishi Iichiroh, Yamamoto Kouhei. Bone marrow niches in myeloid neoplasms PATHOLOGY INTERNATIONAL. 2020.02; 70 (2): 63-71. ( PubMed, DOI )
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Umemori M, Kurata M, Yamamoto A, Yamamoto K, Ishibashi S, Ikeda M, Tashiro K, Kimura T, Sato S, Takahashi H, Kitagawa M. The expression of MYC is strongly dependent on the circular PVT1 expression in pure Gleason pattern 4 of prostatic cancer. Medical molecular morphology. 2020.01; ( PubMed, DOI )
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Yasuda Shunichiro, Aoyama Satoru, Yoshimoto Ryoto, Daisuke Watanabe, Akiyama Hiroki, Umezawa Yoshihiro, Nogami Ayako, Yamamoto Kouhei, Fujiwara Takeo, Edahiro Yoko, Araki Marito, Komatsu Norio, Fukuda Tetsuya, Arai Ayako, Miura Osamu, Kawamata Norihiko. Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations BLOOD. 2019.11; 134 ( DOI )
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Nagaishi T, Yamada D, Suzuki K, Fukuyo R, Saito E, Fukuda M, Watabe T, Tsugawa N, Takeuchi K, Yamamoto K, Arai A, Ohtsuka K, Watanabe M. Indolent T cell lymphoproliferative disorder with villous atrophy in small intestine diagnosed by single-balloon enteroscopy. Clinical journal of gastroenterology. 2019.04; 12 (5): 434-440. ( PubMed, DOI )
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Kawamoto Ami, Nagata Sayaka, Anzai Sho, Takahashi Junichi, Kawai Mao, Hama Minami, Nogawa Daichi, Yamamoto Kouhei, Kuno Reiko, Suzuki Kohei, Shimizu Hiromichi, Hiraguri Yui, Yui Shiro, Oshima Shigeru, Tsuchiya Kiichiro, Nakamura Tetsuya, Ohtsuka Kazuo, Kitagawa Masanobu, Okamoto Ryuichi, Watanabe Mamoru. Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF- in the Inflamed Intestinal Epithelia of IBD Patients JOURNAL OF CROHNS & COLITIS. 2019.04; 13 (4): 495-509. ( PubMed, DOI )
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Kawamoto A., Nagata S., Anzai S., Takahashi J., Kawai M., Hama M., Nogawa D., Yamamoto K., Kuno R., Suzuki K., Shimizu H., Hiraguri Y., Yui S., Oshima S., Tsuchiya K., Nakamura T., Ohtsuka K., Kitagawa M., Okamoto R., Watanabe M.. Synergy of Notch signalling and TNF-alpha in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein JOURNAL OF CROHNS & COLITIS. 2019.03; 13 S91.
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Nagatsuma Misako, Takasawa Kei, Yamauchi Takeru, Nakagawa Ryuichi, Mizuno Tomoko, Tanaka Eriko, Yamamoto Kouhei, Uemura Noriko, Kashimadah Kenichi, Morio Tomohiro. A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus JOURNAL OF HUMAN GENETICS. 2019.02; 64 (2): 177-181. ( PubMed, DOI )
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Mitsumura T, Ito Y, Chiba T, Matsushima T, Kurimoto R, Tanaka Y, Kato T, Uchida K, Ito T, Yamamoto K, Eishi Y, Kitagawa M, Miyazaki Y, Inase N, Asahara H. Ablation of miR-146b in mice causes hematopoietic malignancy. Blood advances. 2018.12; 2 (23): 3483-3491. ( PubMed, DOI )
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Nogawa Daichi, Gulinisha Aihemaiti, Yamamoto Akiko, Onishi Iichiroh, Kurata Morito, Miyasaka Naoyuki, Yamamoto Kohei, Kitagawa Masanobu. Subcellular localization of MCM2 correlates with the prognosis of ovarian clear cell carcinoma CANCER SCIENCE. 2018.12; 109 503.
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Yamamoto Kohei, Abe Shinya, Kurata Morito, Honda Ayaka, Yamamoto Masahide, Kitagawa Masanobu. Ranolazine is a potential anti-tumor reagent against refractory cases in malignant lymphoma CANCER SCIENCE. 2018.12; 109 494.
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Kurata Morito, Yamamoto Kohei, Kitagawa Masanobu. Controllable NRAS expression system and analysis of different signals CANCER SCIENCE. 2018.12; 109 895.
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Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, Fujimaru T, Ando F, Mori T, Okado T, Rai T, Uchida S, Sohara E. Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter. Metabolism: clinical and experimental. 2018.08; 85 23-31. ( PubMed, DOI )
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Takeda Takamori, Kawashima Yoshiyuki, Hirai Chiaki, Makabe Ayane, Ito Taku, Fujikawa Taro, Yamamoto Katsura, Maruyama Ayako, Tsutsumi Takeshi. Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System OTOLOGY & NEUROTOLOGY. 2018.07; 39 (6): e468-e474. ( PubMed, DOI )
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Aihemaiti G, Kurata M, Nogawa D, Yamamoto A, Mineo T, Onishi I, Kinowaki Y, Jin XH, Tatsuzawa A, Miyasaka N, Kitagawa M, Yamamoto K. Subcellular localization of MCM2 correlates with the prognosis of ovarian clear cell carcinoma. Oncotarget. 2018.06; 9 (46): 28213-28225. ( PubMed, DOI )
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Yuko Kinowaki, Morito Kurata, Sachiko Ishibashi, Masumi Ikeda, Anna Tatsuzawa, Masahide Yamamoto, Osamu Miura, Masanobu Kitagawa, Kouhei Yamamoto. Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma. Lab. Invest.. 2018.02; ( PubMed, DOI )
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Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama, Hiroshi Nishina, Daichi Nogawa, Kouhei Yamamoto, Yutaka Hata. Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol. Cancer Res.. 2018.02; 16 (2): 197-211. ( PubMed, DOI )
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Morito Kurata, Kouhei Yamamoto, Branden S Moriarity, Masanobu Kitagawa, David A Largaespada. CRISPR/Cas9 library screening for drug target discovery. J. Hum. Genet.. 2018.02; 63 (2): 179-186. ( PubMed, DOI )
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Kurata Morito, Yamamoto Kouhei, Moriarity Branden S., Kitagawa Masanobu, Largaespada David A.. CRISPR/Cas9 library screening for drug target discovery(和訳中) Journal of Human Genetics. 2018.02; 63 (2): 179-186. ( ichushi )
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Kurata Morito, Yamamoto Kouhei, Kitagawa Masanobu, Noble-Orcutt Klara, Hillesheim Alexandra, Qarni Zain, Sachs Zohar, Largaespada David. Controllable oncogene; new aspects of signaling with controlling oncogene expression CANCER SCIENCE. 2018.01; 109 457.
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Tatsuzawa Anna, Yamamoto Kouhei, Ohata Yae, Ohyama Yoshio, Mochizuki Yumi, Komatsu Hiroyoshi, Kitagawa Masanobu. Clinicopathologic and gene mutation analysis of oral diffuse large B-cell lymphoma CANCER SCIENCE. 2018.01; 109 684.
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Kinowaki Yuko, Yamamoto Kohei, Kurata Morito, Onishi Iichiroh, Kitagawa Masanobu. Clinico-pathological analysis of GPX4 expression in Diffuse large B cell lymphoma CANCER SCIENCE. 2018.01; 109 683.
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Yae Ohata, Anna Tatsuzawa, Yoshio Ohyama, Ayako Ichikawa, Yumi Mochizuki, Sachiko Ishibashi, Yuri Itakura, Urara Sakurai, Kei Sakamoto, Tohru Ikeda, Masanobu Kitagawa, Kouhei Yamamoto. A distinctive subgroup of oral EBV+ B-cell neoplasm with polymorphous features is potentially identical to EBV+ mucocutaneous ulcer. Hum. Pathol.. 2017.11; 69 129-139. ( PubMed, DOI )
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Akira Toriihara, Ayako Arai, Masashi Nakadate, Kouhei Yamamoto, Ken-Ichi Imadome, Osamu Miura, Ukihide Tateishi. FDG-PET/CT findings of chronic active Epstein-Barr virus infection. Leuk. Lymphoma. 2017.10; 59 (6): 1-4. ( PubMed, DOI )
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Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu, Kouhei Yamamoto, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. Correction: EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. PLoS ONE. 2017.10; 12 (8): e0182682. ( PubMed, DOI )
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Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu, Kouhei Yamamoto, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. PLoS ONE. 2017.10; 12 (3): e0174136. ( PubMed, DOI )
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木脇 祐子, 山本 浩平, 倉田 盛人, 大西 威一郎, 北川 昌伸. びまん性大細胞型B細胞リンパ腫におけるGPX4の臨床病理学的検討 日本癌学会総会記事. 2017.09; 76回 P-2230. ( ichushi )
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倉田 盛人, 山本 浩平, 北川 昌伸. 発現調整可能な癌遺伝子 癌遺伝子の発現調整による新たなシグナリングの解析について 日本癌学会総会記事. 2017.09; 76回 J-2055. ( ichushi )
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山本 浩平, 阿部 晋也, 倉田 盛人, 本田 彩華, 武村 太郎, 花形 信孝, 北川 昌伸. 悪性リンパ腫におけるミトコンドリア三機能タンパク過剰発現の臨床病理・分子学的検討 日本癌学会総会記事. 2017.09; 76回 P-2231. ( ichushi )
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立澤 杏奈, 山本 浩平, 大畑 八重, 大山 厳雄, 望月 裕美, 小松 博義, 北川 昌伸. 口腔びまん性大細胞B細胞性リンパ腫における遺伝子変異解析および臨床病理学的検討 日本癌学会総会記事. 2017.09; 76回 P-2233. ( ichushi )
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Kohei Kato, Takeshi Namiki, Makiko Ueno, Madoka Iikawa, Shown Tokoro, Aya Nishizawa, Kouhei Yamamoto, Keiko Miura, Hiroo Yokozeki. A Case of Primary Cutaneous Gamma-Delta T-Cell Lymphoma with Pautrier Microabscess. Annals of Dermatology. 2017.04; 29 (2): 229-232. ( PubMed, DOI )
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Ayano Imai, Hiroshi Takase, Ken-Ichi Imadome, Go Matsuda, Iichiro Ohnishi, Kouhei Yamamoto, Takumi Kudo, Yoji Tanaka, Taketoshi Maehara, Osamu Miura, Ayako Arai. Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis. Intern. Med.. 2017.01; 56 (11): 1409-1414. ( PubMed, DOI )
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Miyamoto Norikazu, Kurata Morito, Nagiri Toshiya, Abe Shinya, Yamamoto Kouhei, Onishi Iichiroh, Kirimura Susumu, Murayama Toshihiko, Hidaka Michihiro, Kitagawa Masanobu. Differential expression of ACINUS variants in bone marrow in myelodysplastic syndromes INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2017; 10 (4): 4330-4338.
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Jin XH, Yamamoto K, Abe S, Onishi I, Kirimura S, Aihemaiti G, Kinowaki Y and Kitagawa M. Prognostic Impact of Cancer Stem Cell-Like Phenotypes in Pancreatic Ductal Adenocarcinoma Journal of Clinical and Experimental Pathology . 2016.10; 6 (295): ( DOI )
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Sumito Shingaki, Yumiko Yoshiki, Kouhei Yamamoto, Yasunori Ota, Kenshi Suzuki. Coexistent adrenal diffuse large B cell lymphoma in a patient with Waldenström's macrogloblinemia/lymphoplasmacytic lymphoma. Annals of Hematology. 2016.10; 95 (10): 1723-1724. ( PubMed, DOI )
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Shunichiro Yasuda, Keisuke Tanaka, Ayako Ichikawa, Ken Watanabe, Emi Uchida, Masahide Yamamoto, Kouhei Yamamoto, Daisuke Mizuchi, Osamu Miura, Tetsuya Fukuda. Aggressive TAFRO syndrome with reversible cardiomyopathy successfully treated with combination chemotherapy. International Journal of Hematology. 2016.10; 104 (4): 512-518. ( PubMed, DOI )
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Kazuhito Suzuki, Kouhei Yamamoto, Yasuhiro Arakawa, Hisashi Yamada, Keisuke Aiba, Masanobu Kitagawa. Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL. Anticancer Drugs. 2016.10; 27 (8): 756-765. ( PubMed, DOI )
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Susumu Kirimura, Morito Kurata, Yasunori Nakagawa, Iichiroh Onishi, Shiho Abe-Suzuki, Shinya Abe, Kouhei Yamamoto, Masanobu Kitagawa. Role of microRNA-29b in myelodysplastic syndromes during transformation to overt leukaemia. Pathology. 2016.04; 48 (3): 233-241. ( PubMed, DOI )
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Kouhei Yamamoto, Yukako Miwa, Shiho Abe-Suzuki, Shinya Abe, Susumu Kirimura, Iichiroh Onishi, Masanobu Kitagawa, Morito Kurata. Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review). Mol Med Rep. 2016.01; 13 (1): 587-591. ( PubMed, DOI )
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Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O, Arai A.. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Medicine. 2015.10; 4 (10): 1494-1504. ( DOI )
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Yoshimori M, Takada H, Imadome KI, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O, Arai A.. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Med.. 2015.07; ( PubMed, DOI )
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Abe S, Yokomizo N, Kobayashi Y, Yamamoto K.. Confirmation of immunoglobulin heavy chain rearrangement by polymerase chain reaction using surgically obtained, paraffin-embedded samples to diagnose primary palate mucosa-associated lymphoid tissue lymphoma: A case study. Int J Surg Case Rep.. 2015.03; 10 129-133. ( PubMed, DOI )
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Onishi I, Nakagawa Y, Murayama T, Hidaka M, Yamamoto K, Abe-Suzuki S, Abe S, Kurata M, Kitagawa M.. Expression of multidrug resistance 1 gene in association with CXCL12 in chronic myelogenous leukaemia. Pathology.. 2014.12; 46 (7): 623-629. ( PubMed, DOI )
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Yukiko Tone, Yoko Kidani, Chihiro Ogawa, Kouhei Yamamoto, Masato Tsuda, Christian Peter, Herman Waldmann, Masahide Tone. Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer. J. Immunol.. 2014.04; 192 (8): 3915-3924. ( PubMed, DOI )
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Yagi K, Yamamoto K, Umeda S, Abe S, Suzuki S, Onishi I, Kirimura S, Fukayama M, Arai A, Kitagawa M, Kurata M.. Expression of multidrug resistance 1 gene in B-cell lymphomas: association with follicular dendritic cells. Histopathology.. 2013.02; 62 (3): 414-420. ( PubMed, DOI )
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Abe S, Kurata M, Suzuki S, Yamamoto K, Aisaki K, Kanno J, Kitagawa M.. Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis. PLoS One.. 2012.06; 7 (6): e7-e8. ( PubMed, DOI )
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Umeda S, Yamamoto K, Murayama T, Hidaka M, Kurata M, Ohshima T, Suzuki S, Sugawara E, Kawano F, Kitagawa M.. Prognostic significance of HOXB4 in de novo acute myeloid leukemia. Hematology.. 2012.05; 17 (3): 125-131.
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Suzuki S, Kurata M, Abe S, Miyazawa R, Murayama T, Hidaka M, Yamamoto K, Kitagawa M.. Overexpression of MCM2 in myelodysplastic syndromes: association with bone marrow cell apoptosis and peripheral cytopenia. Exp Mol Pathol.. 2012.02; 92 (1): 160-166.
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Sugawara E, Yamamoto K, Umeda S, Suzuki S, Kurata M, Endo Y, Uchibori K, Akashi T, Inase N, Kitagawa M.. Giant cell carcinoma causing rapidly progressive respiratory failure as the presenting feature of AIDS. Int J STD AIDS.. 2012.02; 23 (7): e7-e8.
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Masanobu Kitagawa, Morito Kurata, Kouhei Yamamoto, Shinya Abe, Shiho Suzuki, Shigeaki Umeda.. Molecular pathology of myelodysplastic syndromes: biology of medullary stromal and hematopoietic cells (review). Mol Med Report.. 2011.08; 4 (4): 591-596. ( PubMed )
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Kurata M, Abe S, Suzuki S, Li N, Ohnishi I, Hasegawa M, Yamamoto K, Kitagawa M.. DNA damage-induced apoptosis and genetic background of the host: host-specific signaling enhancers of apoptosis. J Med Dent Sci.. 2011.07; 58 (2): 85-88. ( PubMed )
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Smith TJ, Yamamoto K, Kurata M, Yukimori A, Suzuki S, Umeda S, Sugawara E, Kojima Y, Sawabe M, Nakagawa Y, Suzuki K, Crawley JT, Kitagawa M.. Differential expression of Toll-like receptors in follicular lymphoma, diffuse large B-cell lymphoma and peripheral T-cell lymphoma. Exp Mol Pathol.. 2011.07; 58 (2): 85-88. ( PubMed, DOI )
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Niino D, Yamamoto K, Tsuruta O, Maeda T, Yakushijin Y, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Sugita Y, Ohshima K.. Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments. Pathol Int.. 2010.07; 60 (6): 438-442. ( PubMed, DOI )
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Kuninaka N, Kurata M, Yamamoto K, Suzuki S, Umeda S, Kirimura S, Arai A, Nakagawa Y, Suzuki K, Kitagawa M.. Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia. Exp Mol Pathol.. 2010.04; 88 (2): 293-298. ( PubMed, DOI )
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Hasegawa M, Kurata M, Yamamoto K, Yoshida K, Aizawa S, Kitagawa M.. A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70. Leuk Res.. 2009.08; 33 (8): 1100-1107. ( PubMed, DOI )
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Konstantinou K, Yamamoto K, Ishibashi F, Mizoguchi Y, Kurata M, Nakagawa Y, Suzuki K, Sawabe M, Ohta M, Miyakoshi S, Crawley JT, Kitagawa M.. Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma. Br J Haematol.. 2009.03; 144 (5): 696-704. ( PubMed, DOI )
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Shiraishi J, Nakagawa Y, Kurata M, Yamamoto K, Abe Y, Toyoda Y, Suzuki K, Kitagawa M, Takemura T.. Follicular lymphoma with marked infiltration of eosinophils. Pathol Int.. 2008.11; 58 (11): 701-705.
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Kurata M, Nakagawa Y, Yamamoto K, Suzuki K, Kitagawa M.. Induction of integrin beta1 expression in bone marrow cells after chemotherapy correlates with the overexpression of lung resistance protein and poor outcome in patients with multiple myeloma. Am J Hematol.. 2008.09; 83 (9): 755-757. ( PubMed, DOI )
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Karube K, Aoki R, Nomura Y, Yamamoto K, Shimizu K, Yoshida S, Komatani H, Sugita Y, Ohshima K.. Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases. Pathol Int.. 2008.02; 58 (2): 89-97.
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Shimizu K, Karube K, Arakawa F, Nomura Y, Komatani H, Yamamoto K, Yoshida S, Aoki R, Sugita Y, Takeshita M, Ohshima K.. Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia virus type 1-associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis. Cancer Sci.. 2007.12; 98 (12): 1875-1850. ( PubMed )
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Abe S, Hasegawa M, Yamamoto K, Kurata M, Nakagawa Y, Suzuki K, Takizawa T, Kitagawa M.. Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells. Exp Mol Pathol.. 2007.12; 83 (3): 405-412. ( PubMed )
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Keith T, Araki Y, Ohyagi M, Hasegawa M, Yamamoto K, Kurata M, Nakagawa Y, Suzuki K, Kitagawa M.. Regulation of angiogenesis in the bone marrow of myelodysplastic syndromes transforming to overt leukaemia. Br J Haematol.. 2007.05; 137 (3): 206-215. ( PubMed )
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Karube K, Guo Y, Suzumiya J, Sugita Y, Nomura Y, Yamamoto K, Shimizu K, Yoshida S, Komatani H, Takeshita M, Kikuchi M, Nakamura N, Takasu O, Arakawa F, Tagawa H, Seto M, Ohshima K.. CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features. Blood.. 2007.04; 109 (7): 3076-3079.
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Kurata M, Hasegawa M, Nakagawa Y, Abe S, Yamamoto K, Suzuki K, Kitagawa M.. Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes. Exp Mol Pathol.. 2006.12; 81 (3): 249-254.
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Nakagawa Y, Abe S, Kurata M, Hasegawa M, Yamamoto K, Inoue M, Takemura T, Suzuki K, Kitagawa M.. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am J Hematol.. 2006.12; 81 (11): 824-831.
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Tamura K, Aoyagi M, Wakimoto H, Tamaki M, Yamamoto K, Yamamoto M, Ohno K.. Malignant transformation eight years after removal of a benign epidermoid cyst: a case report. J Neurooncol.. 2006.08; 79 (1): 67-72.
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Kitagawa M, Utsuyama M, Kurata M, Yamamoto K, Yuasa Y, Ishikawa Y, Arai T, Hirokawa K.. Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo. Cancer Immunol Immunother.. 2005.07; 54 (7): 623-634.
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Nakagawa Y, Hasegawa M, Kurata M, Yamamoto K, Abe S, Inoue M, Takemura T, Hirokawa K, Suzuki K, Kitagawa M.. Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL). Am J Hematol.. 2005.03; 78 (3): 173-180.
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Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia. Leukemia Research. 2004.11;
Conference Activities & Talks 【 display / non-display 】
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Kota Yoshifuji, Yotaro Motomura, Makiko Saito, Ayako Nogami, Genji Kawade, Shiori Watabe, Kouhei Yamamoto, Takahiko Mori, Toshikage Nagao.. TPL2, a New Prognostic Factor and a Potential Therapeutic Target in ABC-DLBCL.. 64th ASH Annual Meeting and Exposition. 2022.12.11 New Orleans
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Ayako Arai, Hiroshi Takase, Kouhei Yamamoto, Hiroki Akiyama, Manabu Mochizuki, Osamu Miura. Gene expression profiling of primary vitreoretinal lymphoma. 57th ASH Annual Meeting and Exposition 2015.12.05 Orlando