Personnel Information

写真a

KOIKE Ryuji


Job title

Professor

Birth date

1961

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo

Laboratory Fax number

+81-3-5803-0396

Mail Address

koike.rheu@tmd.ac.jp

Research Areas, Keywords

medicine, rheumatology, infectious diseases, clinical pharmacology

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1987, Graduated

Degree 【 display / non-display

  • M.D., Ph.D., Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1987.06
    -
    1988.06
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Trainee Resident
  • 1991.01
    -
    1992.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Senior Resident
  • 2005.04
    -
    2007.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Project Associate Professor
  • 2005.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Pharmacovigilance, Project Associate Professor
  • 2007.04
    -
    2017.03
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, a, Professor
  • 2007.04
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Clinical Research Center, Associate Professor
  • 2013.10
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Division of Infection Control and Prevention, Associate Professor
  • 2015.03
    -
    2016.02
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Professor
  • 2017.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Rheumatology, Professor
  • 2017.04
     
     
    Tokyo Medical and Dental University, Institute of Research, Division for Research Innovation, -, Professor
  • 2017.05
     
     
    Tokyo Medical and Dental University, Institute of Research, Division for Research Innovation, -, Professor
  • 2017.06
    -
    2020.03
    Tokyo Medical and Dental University, Institute of Research, Division for Research Innovation, -, Professor
  • 2020.04
    -
    Now
    Tokyo Medical and Dental University, , , Professor

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External Career 【 display / non-display

  • 1987.05
    -
    1988.06
    , Trainee Resident
  • 1991.01
    -
    1992.03
    , Senior Resident
  • 2005.04
    -
    2007.03
    , Project Associate Professor
  • 2007.04
    -
    Now
    , Associate Professor
  • 2009.04
    -
    2013.09
    , Associate Professor
  • 2013.10
    -
    Now
    , Associate Professor
  • 1988.7 Asahi General Hospital,
  • 1991.1 Tokyo Medical and Dental University,
  • 1992.4 Tokyo Metropolitan Institute of Medical science,
  • 1994.9 Tokyo Medical and Dental University,
  • 2003.4 Soka Municipal Hospital,
  • 2005.4 Tokyo Medical and Dental university, Dept. Pharmacovigilance,
  • 2007.4 Tokyo Medical and Dental University Hospital of Medicine, Clinical Cesearch Center,

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Academic Society Affiliations 【 display / non-display

  • American College of Physicians

Research Areas 【 display / non-display

  • Connective tissue disease and allergy

  • Clinical pharmacy

  • Infectious disease medicine

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Lee H, Chubachi S, Namkoong H, Tanaka H, Otake S, Nakagawara K, Morita A, Fukushima T, Watase M, Kusumoto T, Masaki K, Kamata H, Ishii M, Hasegawa N, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Murakami K, Okada Y, Koike R, Kitagawa Y, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K, Japan COVID-19 Task Force.. Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics. Nutrition & diabetes. 2022.08; 12 (1): 38. ( PubMed, DOI )

  2. Fukushima T, Chubachi S, Namkoong H, Otake S, Nakagawara K, Tanaka H, Lee H, Morita A, Watase M, Kusumoto T, Masaki K, Kamata H, Ishii M, Hasegawa N, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Murakami K, Okada Y, Koike R, Kitagawa Y, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K, Japan COVID-19 Task Force.. U-shaped association between abnormal serum uric acid levels and COVID-19 severity: Reports from the Japan COVID-19 Task Force. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022.07; ( PubMed, DOI )

  3. Ota Yusuke, Hongou Natsune, Nukui Yoko, Koike Ryuji, Tohda Shuji, Saito Ryoichi. Evaluation of polymerase chain reaction-based open reading frame typing method for the clonality investigation of Clostridioides difficile isolates ANAEROBE. 2021.12; 72 102462. ( PubMed, DOI )

  4. Tanaka Hiromu, Lee Ho, Morita Atsuho, Namkoong Ho, Chubachi Shotaro, Kabata Hiroki, Kamata Hirofumi, Ishii Makoto, Hasegawa Naoki, Harada Norihiro, Ueda Tetsuya, Ueda Soichiro, Ishiguro Takashi, Arimura Ken, Saito Fukuki, Yoshiyama Takashi, Nakano Yasushi, Mutoh Yoshikazu, Suzuki Yusuke, Murakami Koji, Okada Yukinori, Koike Ryuji, Kitagawa Yuko, Tokunaga Katsushi, Kimura Akinori, Imoto Seiya, Miyano Satoru, Ogawa Seishi, Kanai Takanori, Fukunaga Koichi. Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2021.12; 113 74-81. ( PubMed, DOI )

  5. Takagi M., Ogawa C., Iehara T., Aoki-Nogami Y., Isibashi E., Imai M., Kimura T., Nagata M., Yasuhara M., Masutani M., Yoshimura K., Tomizawa D., Ogawa A., Yonemori K., Kihara T., Nobori K., Hasebe K., Mizutani S., Morio T., Hosoi H., Koike R.. First in Children Phase I Clinical Study of Oral Olaparib in Pediatric Patients with Refractory Solid Tumors PEDIATRIC BLOOD & CANCER. 2021.11; 68 S85-S86.

  6. Ishiguro Nobuhisa, Ito Yoichi M., Iwasaki Sumio, Nagao Miki, Kawamura Hideki, Kanai Shinichiro, Nukui Yoko, Tokuda Koichi, Miyara Takayuki, Igari Hidetoshi, Yamada Koichi, Chikumi Hiroki, Sano Chiaki, Koike Ryuji, Yagi Tetsuya, Murakami Nobuo. Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in hospital wards: a study protocol for a prospective, multi-center, single-arm trial BMC INFECTIOUS DISEASES. 2021.08; 21 (1): 887. ( PubMed, DOI )

  7. Mori Masaaki, Watabe Shinichi, Taguchi Tomoaki, Hasegawa Hisaya, Ishige Mika, Tanuma Naoyuki, Hirakawa Akihiro, Koike Ryuji, Kusuda Satoshi. Study protocol: a multicenter, uncontrolled, open-label study of palivizumab in neonates, infants, and preschool children at high risk of severe respiratory syncytial virus infection BMC PEDIATRICS. 2021.03; 21 (1): 106. ( PubMed, DOI )

  8. Tanaka N, Terao C, Nakayama Y, Sasai T, Umezawa N, Yagyu Y, Ito K, Koike R, Nakashima R, Hatta K, Mizoguchi F. Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease disguising as anti-synthetase syndrome. Rheumatology (Oxford, England). 2021.03; 60 (3): e104-e106. ( PubMed, DOI )

  9. Usui Y, Nukui Y, Koike R, Tohda S, Saito R. Draft Genome Sequence of a Clostridioides difficile Sequence Type 97 Strain Belonging to Hypervirulent Clade 2. Microbiology resource announcements. 2020.04; 9 (14): ( PubMed, DOI )

  10. Yokoyama-Kokuryo Waka, Yamazaki Hayato, Takeuchi Tsutomu, Amano Koichi, Kikuchi Jun, Kondo Tsuneo, Nakamura Seiji, Sakai Ryoko, Hirano Fumio, Nanki Toshihiro, Koike Ryuji, Harigai Masayoshi. Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis ARTHRITIS RESEARCH & THERAPY. 2020.03; 22 (1): 46. ( PubMed, DOI )

  11. Nukui Yoko, Chino Takashi, Tani Chihiro, Sonobe Kazunari, Aiso Yoshibumi, Tohda Shuji, Koike Ryuji, Saito Ryoichi. Molecular epidemiologic and clinical analysis of Helicobacter cinaedi bacteremia in Japan HELICOBACTER. 2020.02; 25 (1): e12675. ( PubMed, DOI )

  12. Utsunomiya M, Dobashi H, Odani T, Saito K, Yokogawa N, Nagasaka K, Takenaka K, Soejima M, Sugihara T, Hagiyama H, Hirata S, Matsui K, Nonomura Y, Kondo M, Suzuki F, Nawata Y, Tomita M, Kihara M, Yokoyama-Kokuryo W, Hirano F, Yamazaki H, Sakai R, Nanki T, Koike R, Miyasaka N, Harigai M. An open-label, randomized controlled trial of sulfamethoxazole-trimethoprim for <i>Pneumocystis</i> prophylaxis: results of 52-week follow-up. Rheumatology advances in practice. 2020; 4 (2): rkaa029. ( PubMed, DOI )

  13. Saito Ryoichi, Usui Yukino, Ayibieke Alafate, Nakajima Jun, Prah Isaac, Sonobe Kazunari, Aiso Yoshibumi, Ito Shiori, Itsui Yasuhiro, Hadano Yoshiro, Nukui Yoko, Koike Ryuji, Tohda Shuji. Hypervirulent clade 2, ribotype 019/sequence type 67 Clostridioides difficile strain from Japan GUT PATHOGENS. 2019.11; 11 (1): 54. ( PubMed, DOI )

  14. Kasai Shoko, Sakai Ryoko, Koike Ryuji, Kohsaka Hitoshi, Miyasaka Nobuyuki, Harigai Masayoshi. Higher risk of hospitalized infection, cardiovascular disease, and fracture in patients with rheumatoid arthritis determined using the Japanese health insurance database Modern Rheumatology. 2019.09; 29 (5): 788-794. ( ichushi )

  15. Nukui Y, Ayibieke A, Taniguchi M, Aiso Y, Shibuya Y, Sonobe K, Nakajima J, Kanehira S, Hadano Y, Tohda S, Koike R, Saito R. Whole-genome analysis of EC129, an NDM-5-, CTX-M-14-, OXA-10- and MCR-1-co-producing Escherichia coli ST167 strain isolated from Japan. Journal of global antimicrobial resistance. 2019.07; 18 148-150. ( PubMed, DOI )

  16. Kameda Hideto, Fujii Takao, Nakajima Ayako, Koike Ryuji, Sagawa Akira, Kanbe Katsuaki, Tomita Tetsuya, Harigai Masayoshi, Suzuki Yasuo, Japan College of Rheumatology subcommittee on the guideline for the use of methotrexate in patients with rheumatoid arthritis. Japan College of Rheumatology guideline for the use of methotrexate in patients with rheumatoid arthritis Modern Rheumatology. 2019.01; 29 (1): 31-40. ( ichushi )

  17. Takagi Masatoshi, Ogawa Chitose, Aoki-Nogami Yuki, Iehara Tomoko, Ishibashi Eri, Imai Minoru, Kihara Tetsuro, Nobori Kiyoshi, Hasebe Kazuhisa, Mizutani Shuki, Kimura Toshimi, Nagata Masashi, Yasuhara Masato, Yoshimura Kenichi, Yorozu Pariko, Hosoi Hajime, Koike Ryuji. Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol BMC PEDIATRICS. 2019.01; 19 (1): 31. ( PubMed, DOI )

  18. Kasai S, Sakai R, Koike R, Kohsaka H, Miyasaka N, Harigai M. Higher risk of hospitalized infection, cardiovascular disease, and fracture in patients with rheumatoid arthritis determined using the Japanese health insurance database. Modern rheumatology. 2018.11; 1-7. ( PubMed, DOI )

  19. Hideto Kameda, Takao Fujii, Ayako Nakajima, Ryuji Koike, Akira Sagawa, Katsuaki Kanbe, Tetsuya Tomita, Masayoshi Harigai, Yasuo Suzuki, . Japan College of Rheumatology guideline for the use of methotrexate in patients with rheumatoid arthritis. Mod Rheumatol. 2018.05; 1-10. ( PubMed, DOI )

  20. Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai. No increased risk of herpes zoster in TNF inhibitor and non-TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database. Int J Rheum Dis. 2018.04; ( PubMed, DOI )

  21. Shinji Ogihara, Ryoichi Saito, Etsuko Sawabe, Takahiro Kozakai, Mari Shima, Yoshibumi Aiso, Toshihide Fujie, Yoko Nukui, Ryuji Koike, Michio Hagihara, Shuji Tohda. Molecular typing of methicillin-resistant Staphylococcus aureus: Comparison of PCR-based open reading frame typing, multilocus sequence typing, and Staphylococcus protein A gene typing. J. Infect. Chemother.. 2018.04; 24 (4): 312-314. ( PubMed, DOI )

  22. Ogihara Shinji, Saito Ryoichi, Sawabe Etsuko, Kozakai Takahiro, Shima Mari, Aiso Yoshibumi, Fujie Toshihide, Nukui Yoko, Koike Ryuji, Hagihara Michio, Tohda Shuji. Molecular typing of methicillin-resistant Staphylococcus aureus: Comparison of PCR-based open reading frame typing, multilocus sequence typing, and Staphylococcus protein A gene typing Journal of Infection and Chemotherapy. 2018.04; 24 (3-4): 312-314. ( ichushi )

  23. Harigai Masayoshi, Utsunomiya Masako, Dobashi Hiroaki, Odani Toshio, Saito Kazuyoshi, Yokogawa Naoto, Nagasaka Kenji, Takenaka Kenchi, Soejima Makoto, Sugihara Takahiko, Hagiyama Hiroyuki, Hirata Shinya, Matsui Kazuo, Nonomura Yoshinori, Kondo Masahiro, Suzuki Fumihito, Tomita Makoto, Kihara Mari, Yokoyama Waka, Hirano Fumio, Yamazaki Hayato, Sakai Ryoko, Nanki Toshihiro, Koike Ryuji, Kohsaka Hitoshi, Miyasaka Nobuyuki. Optimal Regimens of Sulfamethoxazole-Trimethoprim for Chemoprophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Diseases: 52-Week Follow-up of a Non-Blinded, Randomized Controlled Trial ARTHRITIS & RHEUMATOLOGY. 2017.10; 69

  24. Hirano Fumio, Yokoyama Waka, Yamazaki Hayato, Amano Koichi, Kawakami Atsushi, Hayashi Taichi, Tamura Naoto, Yasuda Shinsuke, Dobashi Hiroaki, Fujii Takao, Ito Satoshi, Kaneko Yuko, Matsui Toshihiro, Okuda Yasuaki, Saito Kazuyoshi, Suzuki Fumihito, Yoshimi Ryusuke, Sakai Ryoko, Koike Ryuji, Kohsaka Hitoshi, Miyasaka Nobuyuki, Harigai Masayoshi, T2T Epidemiological Study Group. 活動性関節リウマチ患者におけるsimplified disease activity index寛解到達は目標達成に向けた治療方針下の実際の臨床環境におけるその後の良好な機能的および構造的転帰に関連する(Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy) Modern Rheumatology. 2017.09; 27 (5): 811-819. ( ichushi )

  25. Yamazaki Hayato, Hirano Fumio, Takeuchi Tsutomu, Amano Koichi, Kikuchi Jun, Kihara Mari, Yokoyama Waka, Sugihara Takahiko, Nagasaka Kenji, Hagiyama Hiroyuki, Nonomura Yoshinori, Sakai Ryoko, Tanaka Michi, Koike Ryuji, Nanki Toshihiro, Kohsaka Hitoshi, Miyasaka Nobuyuki, Harigai Masayoshi. 関節リウマチ患者におけるアバタセプト治療中の6ヵ月時のSimplified Disease Activity Index寛解は12ヵ月時の機能的および構造的寛解の独立予測因子である 日本における多施設共同前向きコホート研究(Simplified Disease Activity Index remission at month 6 is an independent predictor of functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis: A multi-center, prospective cohort study in Japan) Modern Rheumatology. 2017.09; 27 (5): 787-794. ( ichushi )

  26. Masako Utsunomiya, Hiroaki Dobashi, Toshio Odani, Kazuyoshi Saito, Naoto Yokogawa, Kenji Nagasaka, Kenchi Takenaka, Makoto Soejima, Takahiko Sugihara, Hiroyuki Hagiyama, Shinya Hirata, Kazuo Matsui, Yoshinori Nonomura, Masahiro Kondo, Fumihito Suzuki, Makoto Tomita, Mari Kihara, Waka Yokoyama, Fumio Hirano, Hayato Yamazaki, Ryoko Sakai, Toshihiro Nanki, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai. Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial. Arthritis Research and Therapeutics. 2017.01; 19 (1): 7. ( PubMed, DOI )

  27. Gene Igawa, Mika Casey, Etsuko Sawabe, Yoko Nukui, Shu Okugawa, Kyoji Moriya, Ryuji Koike, Shuji Tohda, Ryoichi Saito. Comparison of agar dilution and broth microdilution methods for Clostridium difficile antimicrobial susceptibility testing. J Glob Antimicrob Resist. 2016.12; 7 43-45. ( PubMed, DOI )

  28. Hayato Yamazaki, Fumio Hirano, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Mari Kihara, Waka Yokoyama, Takahiko Sugihara, Kenji Nagasaka, Hiroyuki Hagiyama, Yoshinori Nonomura, Ryoko Sakai, Michi Tanaka, Ryuji Koike, Toshihiro Nanki, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai. Simplified Disease Activity Index remission at month 6 is an independent predictor of functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis: A multi-center, prospective cohort study in Japan. Mod Rheumatol. 2016.12; 1-8. ( PubMed, DOI )

  29. Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai, . Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy. Mod Rheumatol. 2016.12; 1-9. ( PubMed, DOI )

  30. Takeshi Kusuda, Tadashi Hosoya, Takayasu Mori, Katsuhito Ihara, Hidenori Nishida, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Ryuji Koike, Shinichi Uchida, Hitoshi Kohsaka. Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation. Intern. Med.. 2016.11; 55 (21): 3201-3204. ( PubMed, DOI )

  31. Masayoshi Harigai, Toshihiro Nanki, Ryuji Koike, Michi Tanaka, Kaori Watanabe-Imai, Yukiko Komano, Ryoko Sakai, Hayato Yamazaki, Takao Koike, Nobuyuki Miyasaka. Risk for malignancy in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs compared to the general population: A nationwide cohort study in Japan. Mod Rheumatol. 2016.03; 1-9. ( PubMed, DOI )

  32. Ryoko Sakai, Fumio Hirano, Mari Kihara, Waka Yokoyama, Hayato Yamazaki, Sayoko Harada, Toshihiro Nanki, Ryuji Koike, Nobuyuki Miyasaka, Masayoshi Harigai. High prevalence of cardiovascular comorbidities in patients with rheumatoid arthritis from a population-based cross-sectional study of a Japanese health insurance database. Mod Rheumatol. 2015.12; 1-7. ( PubMed, DOI )

  33. Michi Tanaka, Ryoko Sakai, Ryuji Koike, Masayoshi Harigai. Pneumocystis Jirovecii Pneumonia in Japanese Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors: A Pooled Analysis of 3 Agents. J. Rheumatol.. 2015.09; 42 (9): 1726-1728. ( PubMed, DOI )

  34. Y Kuwata, S Tanimoto, E Sawabe, M Shima, Y Takahashi, H Ushizawa, T Fujie, R Koike, N Tojo, T Kubota, R Saito. Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from a university teaching hospital in Japan. Eur. J. Clin. Microbiol. Infect. Dis.. 2015.04; 34 (4): 763-772. ( PubMed, DOI )

  35. Hayato Yamazaki, Ryoko Sakai, Ryuji Koike, Yasunari Miyazaki, Michi Tanaka, Toshihiro Nanki, Kaori Watanabe, Shinsuke Yasuda, Takashi Kurita, Yuko Kaneko, Yoshiya Tanaka, Yasuhiko Nishioka, Yoshinari Takasaki, Kenji Nagasaka, Hayato Nagasawa, Shigeto Tohma, Makoto Dohi, Takahiko Sugihara, Haruhito Sugiyama, Yasushi Kawaguchi, Naohiko Inase, Sae Ochi, Hiroyuki Hagiyama, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai, . Assessment of risks of pulmonary infection during 12 months following immunosuppressive treatment for active connective tissue diseases: a large-scale prospective cohort study. J. Rheumatol.. 2015.04; 42 (4): 614-622. ( PubMed, DOI )

  36. Ryoko Sakai, Soo-Kyung Cho, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Michi Tanaka, Ryuji Koike, Yoshiya Tanaka, Kazuyoshi Saito, Shintaro Hirata, Koichi Amano, Hayato Nagasawa, Takayuki Sumida, Taichi Hayashi, Takahiko Sugihara, Hiroaki Dobashi, Shinsuke Yasuda, Tetsuji Sawada, Kazuhiko Ezawa, Atsuhisa Ueda, Takao Fujii, Kiyoshi Migita, Nobuyuki Miyasaka, Masayoshi Harigai, . Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry. Arthritis Res. Ther.. 2015; 17 74. ( PubMed, DOI )

  37. Tadashi Hosoya, Fumitaka Mizoguchi, Hisanori Hasegawa, Keiko Miura, Ryuji Koike, Tetsuo Kubota, Nobuyuki Miyasaka, Hitoshi Kohsaka. A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor (TNF) Receptor-associated Periodic Syndrome (TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab. Intern. Med.. 2015; 54 (16): 2069-2072. ( PubMed, DOI )

  38. Michi Tanaka, Ryuji Koike, Ryoko Sakai, Kazuyoshi Saito, Shintaro Hirata, Hayato Nagasawa, Hideto Kameda, Masako Hara, Yasushi Kawaguchi, Shigeto Tohma, Yoshinari Takasaki, Makoto Dohi, Yasuhiko Nishioka, Shinsuke Yasuda, Yasunari Miyazaki, Yuko Kaneko, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Nobuyuki Miyasaka, Masayoshi Harigai. Pulmonary infections following immunosuppressive treatments during hospitalization worsen the short-term vital prognosis for patients with connective tissue disease-associated interstitial pneumonia. Mod Rheumatol. 2014.12; 1-6. ( PubMed, DOI )

  39. Ryoko Sakai, Soo-Kyung Cho, Toshihiro Nanki, Ryuji Koike, Kaori Watanabe, Hayato Yamazaki, Hayato Nagasawa, Koichi Amano, Yoshiya Tanaka, Takayuki Sumida, Atsushi Ihata, Shinsuke Yasuda, Atsuo Nakajima, Takahiko Sugihara, Naoto Tamura, Takao Fujii, Hiroaki Dobashi, Yasushi Miura, Nobuyuki Miyasaka, Masayoshi Harigai, . The risk of serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors decreased over time: a report from the registry of Japanese rheumatoid arthritis patients on biologics for long-term safety (REAL) database. Rheumatol. Int.. 2014.12; 34 (12): 1729-1736. ( PubMed, DOI )

  40. Soo-Kyung Cho, Ryoko Sakai, Toshihiro Nanki, Ryuji Koike, Kaori Watanabe, Hayato Yamazaki, Hayato Nagasawa, Yoshiya Tanaka, Atsuo Nakajima, Shinsuke Yasuda, Atsushi Ihata, Kazuhiko Ezawa, Soyoung Won, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo, Nobuyuki Miyasaka, Sang-Cheol Bae, Masayoshi Harigai, , . A comparison of incidence and risk factors for serious adverse events in rheumatoid arthritis patients with etanercept or adalimumab in Korea and Japan. Mod Rheumatol. 2014.07; 24 (4): 572-579. ( PubMed, DOI )

  41. Shin Fukuda, Toshihiro Nanki, Tomohiro Morio, Hisanori Hasegawa, Ryuji Koike, Nobuyuki Miyasaka. Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses. Mod Rheumatol. 2014.05; 24 (3): 537-539. ( PubMed, DOI )

  42. Satoka Shimogaki, Sayaka Ito, Sachiyo Komatsu, Ryuji Koike, Nobuyuki Miyasaka, Kazuo Umezawa, Tetsuo Kubota. Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome. Mod Rheumatol. 2014.05; 24 (3): 517-524. ( PubMed, DOI )

  43. Ryoichi Saito, Rieko Takahashi, Etsuko Sawabe, Saho Koyano, Yutaka Takahashi, Mari Shima, Hiroto Ushizawa, Toshihide Fujie, Naoki Tosaka, Yuko Kato, Kyoji Moriya, Shuji Tohda, Naoko Tojo, Ryuji Koike, Tetsuo Kubota. First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan. Antimicrob. Agents Chemother.. 2014.05; 58 (5): 2961-2963. ( PubMed, DOI )

  44. Kenji Nakagawa, Eva Gonzalez-Roca, Alejandro Souto, Toshinao Kawai, Hiroaki Umebayashi, Josep María Campistol, Jeronima Cañellas, Syuji Takei, Norimoto Kobayashi, Jose Luis Callejas-Rubio, Norberto Ortego-Centeno, Estíbaliz Ruiz-Ortiz, Fina Rius, Jordi Anton, Estibaliz Iglesias, Santiago Jimenez-Treviño, Carmen Vargas, Julian Fernandez-Martin, Inmaculada Calvo, José Hernández-Rodríguez, María Mendez, María Teresa Dordal, Maria Basagaña, Segundo Bujan, Masato Yashiro, Tetsuo Kubota, Ryuji Koike, Naoko Akuta, Kumiko Shimoyama, Naomi Iwata, Megumu K Saito, Osamu Ohara, Naotomo Kambe, Takahiro Yasumi, Kazushi Izawa, Tomoki Kawai, Toshio Heike, Jordi Yagüe, Ryuta Nishikomori, Juan I Aróstegui. Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes. Ann. Rheum. Dis.. 2013.12; ( PubMed, DOI )

  45. Kaori Watanabe, Ryoko Sakai, Ryuji Koike, Fumikazu Sakai, Haruhito Sugiyama, Michi Tanaka, Yukiko Komano, Yuji Akiyama, Toshihide Mimura, Motohide Kaneko, Hitoshi Tokuda, Takenobu Iso, Mitsuru Motegi, Kei Ikeda, Hiroshi Nakajima, Hirofumi Taki, Tetsuo Kubota, Hirotaka Kodama, Shoji Sugii, Takashi Kuroiwa, Yasushi Nawata, Kazuko Shiozawa, Atsushi Ogata, Shigemasa Sawada, Yoshihiro Matsukawa, Takahiro Okazaki, Masaya Mukai, Mitsuhiro Iwahashi, Kazuyoshi Saito, Yoshiya Tanaka, Toshihiro Nanki, Nobuyuki Miyasaka, Masayoshi Harigai. Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients. Mod Rheumatol. 2013.11; 23 (6): 1085-1093. ( PubMed, DOI )

  46. Ryoko Sakai, Michi Tanaka, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Ryuji Koike, Hayato Nagasawa, Koichi Amano, Kazuyoshi Saito, Yoshiya Tanaka, Satoshi Ito, Takayuki Sumida, Atsushi Ihata, Yoshiaki Ishigatsubo, Tatsuya Atsumi, Takao Koike, Atsuo Nakajima, Naoto Tamura, Takao Fujii, Hiroaki Dobashi, Shigeto Tohma, Takahiko Sugihara, Yukitaka Ueki, Akira Hashiramoto, Atsushi Kawakami, Noboru Hagino, Nobuyuki Miyasaka, Masayoshi Harigai, . Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. Ann. Rheum. Dis.. 2012.11; 71 (11): 1820-1826. ( PubMed, DOI )

  47. Michi Tanaka, Ryoko Sakai, Ryuji Koike, Yukiko Komano, Toshihiro Nanki, Fumikazu Sakai, Haruhito Sugiyama, Hidekazu Matsushima, Toshihisa Kojima, Shuji Ohta, Yoji Ishibe, Takuya Sawabe, Yasuhiro Ota, Kazuhisa Ohishi, Hajime Miyazato, Yoshinori Nonomura, Kazuyoshi Saito, Yoshiya Tanaka, Hayato Nagasawa, Tsutomu Takeuchi, Ayako Nakajima, Hideo Ohtsubo, Makoto Onishi, Yoshinori Goto, Hiroaki Dobashi, Nobuyuki Miyasaka, Masayoshi Harigai. Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors. Mod Rheumatol. 2012.11; 22 (6): 849-858. ( PubMed, DOI )

  48. Ryuji Koike, Michi Tanaka, Yukiko Komano, Fumikazu Sakai, Haruhito Sugiyama, Toshihiro Nanki, Hiroshi Ide, Satoshi Jodo, Kou Katayama, Hidekazu Matsushima, Yusuke Miwa, Koichi Morita, Hiroshi Nakashima, Hiroyuki Nakamura, Masamitsu Natsumeda, Yoshiko Sato, Seitaro Semba, Mutsuto Tateishi, Nobuyuki Miyasaka, Masayoshi Harigai. Tacrolimus-induced pulmonary injury in rheumatoid arthritis patients. Pulm Pharmacol Ther. 2011.08; 24 (4): 401-406. ( PubMed, DOI )

  49. Ryoko Sakai, Yukiko Komano, Michi Tanaka, Toshihiro Nanki, Ryuji Koike, Atsuo Nakajima, Tatsuya Atsumi, Shinsuke Yasuda, Yoshiya Tanaka, Kazuyoshi Saito, Shigeto Tohma, Takao Fujii, Atsushi Ihata, Naoto Tamura, Atsushi Kawakami, Takahiko Sugihara, Satoshi Ito, Nobuyuki Miyasaka, Masayoshi Harigai. The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis. Mod Rheumatol. 2011.08; 21 (4): 444-448. ( PubMed, DOI )

  50. Yukiko Komano, Michi Tanaka, Toshihiro Nanki, Ryuji Koike, Ryoko Sakai, Hideto Kameda, Atsuo Nakajima, Kazuyoshi Saito, Mitsuhiro Takeno, Tatsuya Atsumi, Shigeto Tohma, Satoshi Ito, Naoto Tamura, Takao Fujii, Tetsuji Sawada, Hiroaki Ida, Akira Hashiramoto, Takao Koike, Yoshiaki Ishigatsubo, Katsumi Eguchi, Yoshiya Tanaka, Tsutomu Takeuchi, Nobuyuki Miyasaka, Masayoshi Harigai, . Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the Registry of Japanese Rheumatoid Arthritis Patients for Longterm Safety. J. Rheumatol.. 2011.07; 38 (7): 1258-1264. ( PubMed, DOI )

  51. Tetsuo Kubota, Ryuji Koike. Cryopyrin-associated periodic syndromes: background and therapeutics. Mod Rheumatol. 2010.06; 20 (3): 213-221. ( PubMed, DOI )

  52. Kayoko Kaneko, Yoshinori Nonomura, Kaori Watanabe, Ryuji Koike, Tetsuo Kubota, Masayoshi Harigai, Yoshinori Inoue, Takehisa Iwai, Nobuyuki Miyasaka. Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritis. J. Infect. Chemother.. 2009.10; 15 (5): 312-315. ( PubMed, DOI )

  53. Yukiko Komano, Masayoshi Harigai, Ryuji Koike, Haruhito Sugiyama, Jun Ogawa, Kazuyoshi Saito, Naoya Sekiguchi, Masayuki Inoo, Ikuko Onishi, Hiroyuki Ohashi, Fujio Amamoto, Masayuki Miyata, Hideo Ohtsubo, Kazuko Hiramatsu, Masahiro Iwamoto, Seiji Minota, Naoki Matsuoka, Goichi Kageyama, Kazuyoshi Imaizumi, Hitoshi Tokuda, Yasumi Okochi, Koichiro Kudo, Yoshiya Tanaka, Tsutomu Takeuchi, Nobuyuki Miyasaka. Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients. Arthritis Rheum.. 2009.03; 61 (3): 305-312. ( PubMed, DOI )

  54. Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito S, Yamamura M, Matsubara T, Miyasaka N.. Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis. Mod Rheumatol. 2009; 19 351-357.

  55. Komano Y, Harigai M, Koike R, Sugiyama H, Ogawa J Saito K, Sekiguchi N, Inoo M, Onishi I, Ohashi H, Amamoto F, Miyata M, Ohtsubo H, Hiramatsu K, Iwamoto M, Minota S, Matsuoka N, Kageyama G, Imaizumi K, Tokuda H, Okochi Y, Kudo K, Tanaka Y, Takeuchi T, Miyasaka N.. Pneumocystis pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients. Arthritis Care Res. 2009; 61 (3): 305-312.

  56. Harigai M, Koike R, Miyasaka N.. Pneumocystis pneumonia associated with infliximab in Japan. N Engl J Med. 2007; 357 1874-1876.

  57. Koike R, Kubota T, Hara Y, Ito S, Suzuki K, Yanagisawa K, Uchibori K, Miyasaka N.. A case of Muckle-Wells syndrome caused by a novel H312P mutation in NALP3(cryopyrin). Mod Rheumatol. 2007; 17 496-499.

  58. Koike R, Takeuchi T, Eguchi K, Miyasaka N.. Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis. Mod Rheumatol. 2007; 17 451-458.

  59. Asako Emori, Eisuke Matsushima, Okihiko Aihara, Katsuya Ohta, Ryuji Koike, Nobuyuki Miyasaka, Motoichiro Kato. Cognitive dysfunction in systemic lupus erythematosus. Psychiatry Clin. Neurosci.. 2005.10; 59 (5): 584-589. ( PubMed, DOI )

  60. Kenji Oda, Eisuke Matsushima, Yoshiro Okubo, Katsuya Ohta, Yuji Murata, Ryuji Koike, Nobuyuki Miyasaka, Motoichiro Kato. Abnormal regional cerebral blood flow in systemic lupus erythematosus patients with psychiatric symptoms. J Clin Psychiatry. 2005.07; 66 (7): 907-913. ( PubMed )

  61. H Hagiyama, R Koike, K Nagasaka, Y Nonomura, J Nishio, T Nanki, H Kohsaka, T Kubota, N Miyasaka. Two cases of acute respiratory distress syndrome resulting from adult-onset Still's disease. Mod Rheumatol. 2003.03; 13 (1): 76-80. ( PubMed, DOI )

  62. K Shimabukuro, S Ichinose, R Koike, T Kubota, M Yamaguchi, M Miyasaka, T Aso. Hepatocyte growth factor/scatter factor is implicated in the mode of stromal invasion of uterine squamous cervical cancer. Gynecol. Oncol.. 2001.11; 83 (2): 205-215. ( PubMed, DOI )

  63. R Koike, T Iizuka, T Watanabe, N Miyasaka. The GOR gene product cannot cross-react with hepatitis C virus in humans. Clin. Exp. Immunol.. 2001.06; 124 (3): 429-434. ( PubMed )

  64. Y Nonomura, R Koike, J Nishio, R Tsubata, H Kohsaka, T Kubota, N Miyasaka. Overlap syndrome with cerebral hemorrhage caused by prostaglandin E1 infusion. Intern. Med.. 2001.03; 40 (3): 265-266. ( PubMed )

  65. T Nishimura, R Koike, M Miyasaka. Mammary glands of Aly mice: developmental changes and lactation-related expression of specific proteins, alpha-casein, GLyCAM-1 and MAdCAM-1. Am. J. Reprod. Immunol.. 2000.06; 43 (6): 351-358. ( PubMed )

  66. T Iizuka, T Tanaka, M Suematsu, S Miura, T Watanabe, R Koike, Y Ishimura, H Ishii, N Miyasaka, M Miyasaka. Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats. J. Immunol.. 2000.03; 164 (5): 2463-2471. ( PubMed )

  67. T Nanki, R Koike, N Miyasaka. Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis. Am. J. Gastroenterol.. 1999.11; 94 (11): 3379. ( PubMed, DOI )

  68. H Satoh, T Iizuka, R Koike, N Miyasaka, K Kitada, T Kuramoto, T Serikawa, T Watanabe. Assignment of the Madcam1 gene to rat chromosome 7q11.2-->q12 by fluorescence in situ hybridization, somatic cell hybrids and linkage analysis. Cytogenet. Cell Genet.. 1999.10; 86 (3-4): 223-224. ( PubMed, DOI )

  69. T Iizuka, R Koike, N Miyasaka, M Miyasaka, T Watanabe. Cloning and characterization of the rat MAdCAM-1 cDNA and gene. Biochim. Biophys. Acta. 1998.02; 1395 (3): 266-270. ( PubMed )

  70. T Nanki, R Koike, N Mizushima, H Kohsaka, T Kubota, N Miyasaka. Severe anemia due to hemorrhagic gastritis associated with Sjögren's syndrome. Clin. Exp. Rheumatol.. 1998.02; 16 (1): 105. ( PubMed )

  71. R Koike, T Watanabe, H Satoh, C S Hee, K Kitada, T Kuramoto, T Serikawa, S Miyawaki, M Miyasaka. Analysis of expression of lymphocyte homing-related adhesion molecules in ALY mice deficient in lymph nodes and Peyer's patches. Cell. Immunol.. 1997.08; 180 (1): 62-69. ( PubMed, DOI )

  72. N Mizushima, R Koike, H Kohsaka, Y Kushi, S Handa, H Yagita, N Miyasaka. Ceramide induces apoptosis via CPP32 activation. FEBS Lett.. 1996.10; 395 (2-3): 267-271. ( PubMed )

  73. R Koike, T Nishimura, R Yasumizu, H Tanaka, Y Hataba, Y Hataba, T Watanabe, S Miyawaki, M Miyasaka. The splenic marginal zone is absent in alymphoplastic aly mutant mice. Eur. J. Immunol.. 1996.03; 26 (3): 669-675. ( PubMed, DOI )

  74. H Komachi, K Tsuchiya, M Ikeda, R Koike, T Matsunaga, K Ikeda. Radiation myelopathy: a clinicopathological study with special reference to correlation between MRI findings and neuropathology. J. Neurol. Sci.. 1995.10; 132 (2): 228-232. ( PubMed )

  75. R Koike, I Miki, M Otoshi, T Totsuka, H Inoue, H Kase, I Saito, N Miyasaka. Gold sodium thiomalate down-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells. Mol. Pharmacol.. 1994.10; 46 (4): 599-604. ( PubMed )

  76. M Nanno, S Matsumoto, R Koike, M Miyasaka, M Kawaguchi, T Masuda, S Miyawaki, Z Cai, T Shimamura, Y Fujiura. Development of intestinal intraepithelial T lymphocytes is independent of Peyer's patches and lymph nodes in aly mutant mice. J. Immunol.. 1994.09; 153 (5): 2014-2020. ( PubMed )

  77. T Kuramoto, T Mashimo, R Koike, S Miyawaki, J Yamada, M Miyasaka, T Serikawa. The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11. Int. Immunol.. 1994.07; 6 (7): 991-994. ( PubMed )

  78. H Yoshinaga, R Koike, T Maruyama, H Iizuka, H Matsuoka, T Kubota, N Miyasaka. Still's disease relapse with severe pneumonitis after prolonged remission. Intern. Med.. 1993.12; 32 (12): 902-905. ( PubMed )

  79. R Koike, M Yamada, T Matsunaga, S Yoshida, H Tsukagoshi. Polyarteritis nodosa (PN) complicated with unilateral exophthalmos. Intern. Med.. 1993.03; 32 (3): 232-236. ( PubMed )

  80. N Miyasaka, H Inoue, T Totsuka, R Koike, K Kino, H Tsunoo. An immunomodulatory protein, Ling Zhi-8, facilitates cellular interaction through modulation of adhesion molecules. Biochem. Biophys. Res. Commun.. 1992.07; 186 (1): 385-390. ( PubMed )

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Conference Activities & Talks 【 display / non-display

  1. Masatoshi Takagi, Chitose Ogawa, Tomoko Iehara, Yuki Aoki-Nogami, Eri Isibashi, Minoru Imai, Toshimi Kimura, Masashi Nagata, Masato Yasuhara, Mitsuko Masutani, Kenichi Yoshimura, Daisuke Tomizawa, Atsushi Ogawa, Kan Yonemori, Tetsuro Kihara, Kiyoshi Nobori, Kazuhisa Hasebe, Shuki Mizutani, Tomohiro Morio, Hajime Hosoi, Ryuji Koike. First In Children Phase I Clinical Study Of Oral Olaparib In Pediatric Patients With Refractory Solid Tumors. SIOP2021 2021.10.24 Honolulu(Web)

  2. Ayibieke Alafate, 山田 景士, 相曽 啓史, 羽田野 義郎, 貫井 陽子, 小池 竜司, 東田 修二, 齋藤 良一. 東京の2病院で分離された血中のS.epidermidisの疫学的特性(Epidemiological characteristics of bloodstream S. epidermidis isolates from two hospitals in Tokyo). 日本細菌学雑誌 2020.01.01

  3. Ayibieke Alafate, 山田 景士, 相曽 啓史, 羽田野 義郎, 貫井 陽子, 小池 竜司, 東田 修二, 齋藤 良一. 東京の2病院で分離された血中のS.epidermidisの疫学的特性(Epidemiological characteristics of bloodstream S. epidermidis isolates from two hospitals in Tokyo). 日本細菌学雑誌 2020.01.01

  4. F. Hirano, W. Yokoyama, H. Yamazaki, K. Amano, Y. Kaneko, A. Kawakami, T. Matsui, R. Sakai, R. Koike, N. Miyasaka, M. Harigai. SDAI REMISSION AT WEEK 24 IS A PREDICTOR OF GOOD FUNCTIONAL AND STRUCTURAL OUTCOMES AT WEEK 72 IN A T2T IMPLEMENTING COHORT. EULAR2015 2015.06.11 Rome

Awards & Honors 【 display / non-display

  • Evergreen Award,American College of Physicians,2007.04

 

Performance of duties 【 display / non-display

  • Chief physician of Department of Medicine and Rheumatology,2018.04 - Now