Personnel Information

写真a

ITOH Mai


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, Completed

Campus Career 【 display / non-display

  • 2008.04
    -
    2008.12
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Assistant Professor
  • 2009.10
    -
    2022.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Assistant Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Junior Associate Professor

External Career 【 display / non-display

  • 2009.02
    -
    2009.09
    , Project Researcher

Research Areas 【 display / non-display

  • Hematology and medical oncology

 

Published Papers & Misc 【 display / non-display

  1. Saito T, Itoh M, Tohda S. TYRO3 knockdown suppresses the growth of myeloid leukaemia cells. Anticancer Research. 2022.04; 42 (4): 1757-1761. ( PubMed, DOI )

  2. Sonoda Y, Itoh M, Tohda S. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Research. 2021.04; 41 (4): 1841-1847. ( PubMed, DOI )

  3. Saito T, Itoh M, Tohda S. Metformin suppresses the growth of leukemia cells partly through downregulation of AXL receptor tyrosine kinase Leukemia Research. 2020.05; 94 106383.

  4. Okasha SM, Itoh M, Tohda S . Sirtuin 1 activation suppresses the growth of T-lymphoblastic leukemia cells by inhibiting NOTCH an NF-kB pathways. Anticancer Research. 2020.04; 40 3155-3161.

  5. Itoh M, Okuhashi Y, Takahashi Y, Sonoda Y, Mohammad S, Saito T, Shiratori E, Tohda S. Hypoxia Up-regulates HIF Expression While Suppressing Cell Growth and NOTCH Activity in Leukaemia Cells. Anticancer Research. 2019.08; 39 (8): 4165-4170. ( PubMed, DOI )

  6. Yuki Okuhashi, Mai Itoh, Shuji Tohda. GLI1 and CTNNB1 Knockdown Activates NOTCH and mTOR Signalling in NB4 Myeloid Leukaemia Cells. Anticancer Research. 2018.11; 38 (11): 6329-6332.

  7. Wang S, Itoh M, Shiratori E, Ohtaka M, Tohda S. NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells Hematology Reports. 2018.09; 10 7576.

  8. Wang S, Itoh M, Shiratori E, Ohtaka M, Tohda S. NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells. Hematology reports. 2018.09; 10 (3): 7576. ( PubMed, DOI )

  9. Yonekura S, Itoh M, Shiratori E, Ohtaka M, Tohda S. FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells BMC Research Notes. 2018.08; 11 582.

  10. Yonekura S, Itoh M, Shiratori E, Ohtaka M, Tohda S. FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells. BMC research notes. 2018.08; 11 (1): 582. ( PubMed, DOI )

  11. Koda Y, Itoh M, Tohda S. Effects of MERTK inhibitors UNC569 and UNC1062 on the growth of acute myeloid leukaemia cells. Anticancer Research. 2018.01; 38 (1): 199-204.

  12. Mika Ohtaka, Mai Itoh, Shuji Tohda. BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells. Anticancer Research. 2017.11; 37 (11): 6047-6053. ( PubMed, DOI )

  13. Erika Shiratori, Mai Itoh, Shuji Tohda. MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells. Anticancer Research. 2017.11; 37 (11): 6203-6209. ( PubMed, DOI )

  14. Okuhashi Y, Itoh M, Tohda S. Hedgehog stimulation suppresses clonogenicity and activates NOTCH signalling in T-lymphoblastic leukaemia Jurkat cells. Anticancer Research . 2017.09; 37 (9): 5005-5009.

  15. Nogami S, Kwaguchi-Ihara N, Shiratori E, Ohtaka M, Itoh M, Tohda S. Detection of the MYD88 mutation by the combination of the allele-specific PCR and quenching probe methods. International Journal of Laboratory Hematology . 2017.04; 39 (2): 163-168.

  16. Noriko Kawaguchi-Ihara, Mai Itoh, Ikuo Murohashi, Shuji Tohda. Establishment of a quenching probe method for detection of NPM1 mutations in acute myeloid leukemia cells. Oncology Letters. 2016.04; 11 (4): 2429-2432. ( PubMed, DOI )

  17. Yusuke Takahashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Effect of EPH-ephrin signaling on the growth of human leukemia cells. Anticancer Research. 2014.06; 34 (6): 2913-2918. ( PubMed )

  18. Yuki Okuhashi, Mai Itoh, Nobuo Nara, Shuji Tohda. NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells. Anticancer Research. 2013.10; 33 (10): 4293-4298. ( PubMed )

  19. Satoru Yonekura, Mai Itoh, Yuki Okuhashi, Yusuke Takahashi, Aya Ono, Nobuo Nara, Shuji Tohda. Effects of the HIF1 inhibitor, echinomycin, on growth and NOTCH signalling in leukaemia cells. Anticancer Research. 2013.08; 33 (8): 3099-3103. ( PubMed )

  20. Aya Ono, Ryo Oike, Yuki Okuhashi, Yusuke Takahashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells. Anticancer Research. 2013.03; 33 (3): 809-813. ( PubMed )

  21. Eriko Kanamori, Mai Itoh, Naoko Tojo, Takatoshi Koyama, Nobuo Nara, Shuji Tohda. Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells. Experimental and Therapeutic Medicine. 2012.09; 4 (3): 397-400. ( PubMed, DOI )

  22. Aya Ono, Yuki Okuhashi, Yusuke Takahashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Advantages of the quenching probe method over other PCR-based methods for detection of the JAK2 V617F mutation. Oncology Letters. 2012.08; 4 (2): 205-208. ( PubMed, DOI )

  23. Yusuke Takahashi, Tomohiro Ishigaki, Yuki Okuhashi, Aya Ono, Mai Itoh, Nobuo Nara, Shuji Tohda. Effect of BMP4 on the growth and clonogenicity of human leukemia and lymphoma cells. Anticancer Research. 2012.07; 32 (7): 2813-2817. ( PubMed )

  24. Noriko Kawaguchi-Ihara, Yuki Okuhashi, Mai Itoh, Ikuo Murohashi, Nobuo Nara, Shuji Tohda. Promotion of the self-renewal capacity of human leukemia cells by sonic hedgehog protein. Anticancer Research. 2011.03; 31 (3): 781-784. ( PubMed )

  25. Yuki Okuhashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. Anticancer Research. 2011.03; 31 (3): 893-896. ( PubMed )

  26. Yuki Okuhashi, Mai Itoh, Ayako Arai, Nobuo Nara, Shuji Tohda. Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines. Anticancer Research. 2010.10; 30 (10): 4071-4074. ( PubMed )

  27. Tatsuo Kawahara, Noriko Kawaguchi-Ihara, Yuki Okuhashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Research. 2009.11; 29 (11): 4629-4632. ( PubMed )

  28. Mai Itoh, Lu Fu, Shuji Tohda. NF-kappaB activation induced by Notch ligand stimulation in acute myeloid leukemia cells. Oncology Reports. 2009.09; 22 (3): 631-634. ( PubMed, DOI )

  29. Hiromi Akeboshi, Yasunori Chiba, Yoshiko Kasahara, Minako Takashiba, Yuki Takaoka, Mai Ohsawa, Youichi Tajima, Ikuo Kawashima, Daisuke Tsuji, Kohji Itoh, Hitoshi Sakuraba, Yoshifumi Jigami. Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta. Applied and Environmental Microbiology. 2007.08; 73 (15): 4805-4812. ( PubMed, DOI )

  30. Jihwa Chung, Takatoshi Koyama, Mai Ohsawa, Aya Shibamiya, Asuka Hoshi, Shinsaku Hirosawa. 1,25(OH)(2)D(3) blocks TNF-induced monocytic tissue factor expression by inhibition of transcription factors AP-1 and NF-kappaB. Laboratory Investigation. 2007.06; 87 (6): 540-547. ( PubMed, DOI )

  31. Ikuo Kawashima, Mai Ohsawa, Tomoko Fukushige, Yoshihisa Nagayama, Yo Niida, Masaharu Kotani, Youichi Tajima, Takuro Kanekura, Tamotsu Kanzaki, Hitoshi Sakuraba. Cytochemical analysis of storage materials in cultured skin fibroblasts from patients with I-cell disease. Clinica Chimica Acta. 2007.03; 378 (1-2): 142-146. ( PubMed, DOI )

  32. Ikuo Kawashima, Ichiro Takeuchi, Mai Ohsawa, Masaharu Kotani, Youichi Tajima, Takayuki Inomata, Tohru Izumi, Hitoshi Sakuraba. Phospholipid storage in the myocardium of a unique Japanese case of idiopathic cardiomyopathy. Clinica Chimica Acta. 2006.10; 372 (1-2): 154-157. ( PubMed, DOI )

  33. Yutaka Tatano, Tsutomu Takahashi, Daisuke Tsuji, Naohiro Takeuchi, Kohji Tsuta, Goro Takada, Mai Ohsawa, Hitoshi Sakuraba, Kohji Itoh. Significant decrease in tropoelastin gene expression in fibroblasts from a Japanese Costello syndrome patient with impaired elastogenesis and enhanced proliferation. Journal of Biochemistry. 2006.08; 140 (2): 193-200. ( PubMed, DOI )

  34. Yukako Oheda, Masaharu Kotani, Mai Ohsawa, Hitoshi Sakuraba, Yoshito Kadota, Yutaka Tatano, Jun Kuwahara, Kohji Itoh. Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement. Glycobiology. 2006.04; 16 (4): 271-280. ( PubMed, DOI )

  35. Hitoshi Sakuraba, Mai Ohsawa, Ikuo Kawashima, Youichi Tajima, Masaharu Kotani, Toshio Ohshima, Yasunori Chiba, Minako Takashiba, Yoshifumi Jigami, Tomoko Fukushige, Tamotsu Kanzaki, Kohji Itoh. Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice. Journal of Human Genetics. 2006; 51 (3): 180. ( PubMed, DOI )

  36. Hitoshi Sakuraba, Yasunori Chiba, Masaharu Kotani, Ikuo Kawashima, Mai Ohsawa, Youichi Tajima, Yuki Takaoka, Yoshifumi Jigami, Hiroshi Takahashi, Yukihiko Hirai, Takashi Shimada, Yasuhiro Hashimoto, Kumiko Ishii, Toshihide Kobayashi, Kazuhiko Watabe, Tomoko Fukushige, Tamotsu Kanzaki. Corrective effect on Fabry mice of yeast recombinant human alpha-galactosidase with N-linked sugar chains suitable for lysosomal delivery. Journal of Human Genetics. 2006; 51 (4): 341-352. ( PubMed, DOI )

  37. Mai Ohsawa, Shuji Tohda, Hanae Kogoshi, Seiji Sakano, Nobuo Nara. The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells. Leukemia Research. 2005.02; 29 (2): 197-203. ( PubMed, DOI )

  38. Mai Ohsawa, Masaharu Kotani, Youichi Tajima, Daisuke Tsuji, Yasuhiro Ishibashi, Aya Kuroki, Kohji Itoh, Kazuhiko Watabe, Kazunori Sango, Shoji Yamanaka, Hitoshi Sakuraba. Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human beta-hexosaminidase A on the accumulated GM2 ganglioside. Journal of Human Genetics. 2005; 50 (9): 460-467. ( PubMed, DOI )

  39. Mai Ohsawa, Shuji Tohda, Hanae Kogoshi, Nobuo Nara. The Notch ligand, Delta-1, reduces TNF-alpha-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells. International Journal of Molecular Medicine. 2004.11; 14 (5): 861-866. ( PubMed )

  40. Mai Ohsawa, Shuji Tohda, Nobuo Nara. Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. International Journal of Molecular Medicine. 2004.08; 14 (2): 223-226. ( PubMed )

  41. Mai Ohsawa, Shuji Tohda, Seiji Sakano, Nobuo Nara. The Notch ligand, Delta-1, partially inhibits GM-CSF-induced differentiation and apoptosis along with reducing the cleavage of PARP in U937 cells. International Journal of Molecular Medicine, Tokyo Medical and Dental University. 2004.03; 13 (3): 419-423. ( PubMed )

  42. Shuji Tohda, Mai Ohsawa, Seiji Sakano, Nobuo Nara. Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. International Journal of Oncology. 2003.05; 22 (5): 1073-1079. ( PubMed )

  43. Mai Ohsawa, Takatoshi Koyama, Nobuo Nara, Shinsaku Hirosawa. Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38. Thrombosis Research. 2003; 112 (5-6): 313-320. ( PubMed, DOI )

  44. Shuji Tohda, Seiji Sakano, Mai Ohsawa, Naomi Murakami, Nobuo Nara. A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein. British Journal of Haematology. 2002.05; 117 (2): 373-378. ( PubMed, DOI )

  45. Koyama T, Ohsawa M, Nakazawa F, Shibamiya S . Anticoagulant effects of synthetic retinoids and activated vitamin D3 (1,25(OH)2D3) analogs Modern Trends in Skin Pharmacology. 2002;

  46. M Ohsawa, T Koyama, K Yamamoto, S Hirosawa, S Kamei, R Kamiyama. 1alpha,25-dihydroxyvitamin D(3) and its potent synthetic analogs downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, counteracting the effects of tumor necrosis factor and oxidized LDL. Circulation. 2000.12; 102 (23): 2867-2872. ( PubMed, DOI )

  47. M Ohsawa, T Koyama, M Shibakura, S Kamei, S Hirosawa. Arsenic trioxide (As2O3) gradually downregulates tissue factor expression without affecting thrombomodulin expression in acute promyelocytic leukemia cells. Leukemia. 2000.05; 14 (5): 941-943. ( PubMed, DOI )

  48. T Koyama, M Shibakura, M Ohsawa, R Kamiyama, S Hirosawa. Anticoagulant effects of 1alpha,25-dihydroxyvitamin D3 on human myelogenous leukemia cells and monocytes. Blood. 1998.07; 92 (1): 160-167. ( PubMed )

  49. M Shibakura, T Koyama, M Ohsawa, R Kamiyama, S Hirosawa. A retinoic acid receptor-alpha (RAR alpha) selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils. Blood. 1998.01; 91 (2): 724-725. ( PubMed )

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Conference Activities & Talks 【 display / non-display

  1. 野口琴未、伊藤真以、東田修二. c-MYC阻害剤の白血病細胞の増殖に対する効果. 第68回日本臨床検査医学会学術集会 2021.11.12 富山

  2. Tatsuya Saito, Mai Itoh, Shuji Tohda. Metformin inhibits the growth of myeloid leukemia cells partly due to suppression of TYRO3 expression. The 24th Congress of the European Hematology Association 2019.06.14 Amsterdam, Holland

  3. Mika Ohtaka, Mai Itoh, Shuji Tohda. BMI1 inhibitors suppress cell growth and Notch signalling of acute leukemia cells. The 46th International Society of Experimental Hematology 2017.08.26 Frankfurt, Germany

  4. Erika Shiratori, Mai Itoh, Mika Ohtaka, Shohei Nogami, Shuji Tohda. Mechanisms of suppressive effects of MYD88 inhibitors on the growth of lymphoma and leukemia cells. The 58th American Society of Hematology 2016.12.04 San Diego, USA

  5. Shohei Nogami, Mai Itoh, Shuji Tohda. Highly sensitive detection of MYD88 mutation by combination of allele-specific PCR and quenching probe method. The 14th Asian Society for Clinical Pathology and Laboratory Medicine Congress 2016.03.26 Taipei, Taiwan

  6. Yuki Okuhashi, Yusuke Takahashi, Mika Ohtaka, Erika Shiratori, Shijun O, Mai Itoh, Shuji Tohda. Effets of GLI1 and CTNNB1 knockdown on Notch signaling and proliferation of AML and T-ALL cell lines. The 56th American Society of Hematology 2014.12.06 San Francisco, USA

  7. Mai Itoh, Yusuke Takahashi, Yuki Okihashi, Shuji Tohda. Effects of hypoxia on HIF, Notch, Akt, and NF-kB signaling in leukemia cell lines. The 55th American Society of Hematology 2013.12.09 New Orleans, USA

  8. Yuki Okuhashi, Mai Itoh, Nobuo Nara, Shuji Tohda. Effects of NOTCH knockdown on the proliferation and mTOR signaling of T-ALL and AML cell lines. The 55th American Society of Hematology 2013.12.07 New Orleans, USA

  9. Akeboshi H, Chiba Y, Kasahara Y, Takaoka Y, Ohsawa M, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y. Production of recombinant beta-hexosaminidase A that is applicable to enzyme replacement therapy for GM2 gangliosidosis, in methylotrophic yeast. Annual Conference of The Society for Glycobiology 2006.11 Los Angeles, USA

  10. Akeboshi H, Chiba Y, Kasahara Y, Takaoka Y, Ohsawa M, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y. Production of recombinant beta-hexosaminidase A that is applicable to enzyme replacement therapy for GM2 gangliosidosis, in methylotrophic yeast. Annual Conference of The Society for Glycobiology 2006.11 Los Angeles, USA

  11. Murayama K, Shimada Y, Takita H, Otake A, Ohsawa M, Sakuraba H, Yoneya S. Electrophysiological and clinical aspects of adult-form galactosialidosis. The 44th Annual Symposium of International Society for Clinical Electrophysiology of Vision 2006.11 Fontevraud, France

  12. Sakuraba H, Matsuzawa F, Aikawa S, Kotani M, Kawashima I, Ohsawa M, Tajima Y, Chiba Y, Kanzaki T. Structural basis of Fabry disease and corrective effect of yeast recombinant human alpha-galactosidase on Fabry mice. The 10th International Congress of Inborn Errors of Metabolism 2006.09 Chiba, Japan

  13. Kawashima I, Ohsawa M, Kotani M, Tajima Y, Itoh K, Watabe K, Sakuraba H. Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human beta-hexosaminidase A on the accumulated GM2 ganglioside. The 10th International Congress of Inborn Errors of Metabolism 2006.09 Chiba, Japan

  14. Tsuji D, Kuga N, Ohsawa M, Sakuraba H, Itoh K. Analysis of glycoconjugates accumulated in oligodendrocyte precursor cells and Schwann cells derived from Sandhoff disease model mice. The 20th IUBMB International Congress of Biochemistry and Molecular Biology and The 11th FAOBMB Congress 2006.06 Kyoto, Japan

  15. Tatano Y, Fujinawa R, Yamamoto H, Kozutsumi Y, Takeuchi N, Tsuta K, Ohsawa M, Sakuraba H, Takahashi T, Takada G, Itoh K. Up-regulation of chemokine and cytokine expression in skin fibroblast derived from Costello syndrome with impaired elastogenesis. The 20th IUBMB International Congress of Biochemistry and Molecular Biology and The 11th FAOBMB Congress 2006.06 Kyoto, Japan

  16. Ohsawa M, Koyama T, Nakazawa F, Kamiyama R. 1a,25-dihydroxyvitamin D3 and its potent synthetic analogs downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, counteracting the effects of tumor necrosis factor and oxidized low-density lipoprotein. Athens Dermatology Symposium 2000.06 Athens, Greece

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