Personnel Information

写真a

FUNAKOSHI Takeshi


Job title

Assistant Professor

Mail Address

The inquiry by e-mail is 《here》
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Graduating School 【 display / non-display 】

  • Yamaguchi University, Faculty of Agriculture, 2001.03, Graduated

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Graduate School 【 display / non-display 】

  • Yamaguchi University, Graduate School, Division of Agriculture, Master's Course, 2003.03, Completed

  • Yamaguchi University, Graduate School, Division of Medicine, Doctor's Course, 2006.07, Accomplished credits for doctoral program

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Degree 【 display / non-display 】

  • Ph.D., Yamaguchi University

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Campus Career 【 display / non-display 】

  • 2008.09
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Assistant Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Assistant Professor
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External Career 【 display / non-display 】

  • 2006.08
    -
    2008.08
    , Assistant Professor
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Research Areas 【 display / non-display 】

  • Medical biochemistry

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Published Papers & Misc 【 display / non-display 】

  1. Kana Unuma, Shuheng Wen, Sho Sugahara, Shutaro Nagano, Toshihiko Aki, Tadayuki Ogawa, Shino Takeda-Homma, Masakazu Oikawa, Akihiro Tojo. Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats. Arch Toxicol. 2024.10; ( PubMed, DOI )

  2. Hikari Tachibana, Moeka Nomura, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemura. Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940. Neurotoxicology. 2024.06; 103 215-221. ( PubMed, DOI )

  3. Sho Sugahara, Kana Unuma, Shuheng Wen, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. PLoS One. 2024; 19 (12): e0311884. ( PubMed, DOI )

  4. Moeka Nomura, Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochem Biophys Res Commun. 2023.12; 695 149438. ( PubMed, DOI )

  5. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling. Biochem Biophys Res Commun. 2023.07; 676 30-35. ( PubMed, DOI )

  6. Toshihiko Aki, Hiroki Tanaka, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochem Biophys Res Commun. 2023.07; 676 66-72. ( PubMed, DOI )

  7. Toshihiko Aki, Mitsuki Kukita, Mao Takata, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure. Biochem Biophys Res Commun. 2023.04; 651 92-97. ( PubMed, DOI )

  8. Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2023.03; 378 39-50. ( PubMed, DOI )

  9. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022.10; 23 (19): ( PubMed, DOI )

  10. Shuheng Wen, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. Int J Mol Sci. 2022.05; 23 (10): ( PubMed, DOI )

  11. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis. 2022.01; ( PubMed, DOI )

  12. Sho Aoki, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol. Toxicol Rep. 2022; 9 2020-2029. ( PubMed, DOI )

  13. Unuma K, Kaga H, Funakoshi T, Nomura M, Aki T, Uemura K. Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PloS one. 2022; 17 (11): e0277032. ( PubMed, DOI )

  14. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration. Sci Rep. 2021.12; 11 (1): 24129. ( PubMed, DOI )

  15. Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2021.07; 350 240-248. ( PubMed, DOI )

  16. Midori Nagai, Koichi Sakurada, Kazuhiko Imaizumi, Yoshinori Ogawa, Motohiro Uo, Takeshi Funakoshi, Koichi Uemura. Evaluation of Parameters for Estimating the Postmortem Interval of Skeletal Remains Using Bovine Femurs: A Pilot Study. Diagnostics (Basel). 2020.12; 10 (12): ( PubMed, DOI )

  17. Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells. Sci Rep. 2020.06; 10 (1): 10581. ( PubMed, DOI )

  18. Toshihiko Aki, Kana Unuma, Kanako Noritake, Naho Hirayama, Takeshi Funakoshi, Koichi Uemura. Formation of high molecular weight p62 by CORM-3. PLoS ONE. 2019; 14 (1): e0210474. ( PubMed, DOI )

  19. Takeshi Funakoshi, Mako Furukawa, Toshihiko Aki, Koichi Uemura. Repeated exposure of cocaine alters mitochondrial dynamics in mouse neuroblastoma Neuro2a. Neurotoxicology. 2019; 75 70-77. ( PubMed, DOI )

  20. Toshihiko Aki, Kana Unuma, Kanako Noritake, Hatsumi Kurahashi, Takeshi Funakoshi, Koichi Uemura. Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin. Toxicol In Vitro. 2018.03; 50 201-209. ( PubMed, DOI )

  21. Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci. 2018.03; 43 (3): 193-202. ( PubMed, DOI )

  22. Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.. Modes of Chemically Induced Cell Death. Comprehensive Toxicology 3rd ed Volume 1 (General subjects). 2017.12;

  23. Kanako Noritake, Toshihiko Aki, Moe Kimura, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017.10; 42 (5): 545-551. ( PubMed, DOI )

  24. Ryo Watanabe, Kana Unuma, Kanako Noritake, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura.. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. J. Toxicologic Pathology. 2017.07; 30 333-337.

  25. Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura. A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem. Biophys. Res. Commun.. 2017.06; 487 (3): 748-754. ( PubMed, DOI )

  26. Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. J. Biol. Chem.. 2016.11; 291 (48): 25050-25065. ( PubMed, DOI )

  27. Haruka Kimura-Kojima, Kana Unuma, Takeshi Funakoshi, Chizuru Kato, Ayumi Komatsu, Toshihiko Aki, Koichi Uemura. Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. J Toxicol Pathol. 2016.04; 29 (2): 131-138. ( PubMed, DOI )

  28. Yusuke Fujii, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Toshihiko Aki, Koichi Uemura. Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016; 41 (5): 645-654. ( PubMed, DOI )

  29. Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura. Regulated necrosis and its implications in toxicology. Toxicology. 2015.07; 333 118-126. ( PubMed, DOI )

  30. Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Koichi Uemura. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015; 10 (3): e0120192. ( PubMed, DOI )

  31. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Kyoko Hashimoto, Koichi Uemura. Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy. 2015; 11 (9): 1520-1536. ( PubMed, DOI )

  32. Kanako Noritake, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015; 10 (8): e0136952. ( PubMed, DOI )

  33. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014.08; 322 43-50. ( PubMed, DOI )

  34. Uchida K, Unuma K, Funakoshi T, Aki T, Uemura K. Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea. J Toxicol Pathol. 2014.07; 27 (2): 153-158. ( PubMed, DOI )

  35. Izumi Funakoshi-Hirose, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Kanako Noritake, Koichi Uemura. Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology. 2013.10; 312 74-82. ( PubMed, DOI )

  36. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Impairment of autophagy: from hereditary disorder to drug intoxication. Toxicology. 2013.09; 311 (3): 205-215. ( PubMed, DOI )

  37. Marie Bessho, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Chizuru Kato, Koichi Uemura. Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells. Cardiovasc. Toxicol.. 2013.09; 13 (3): 267-277. ( PubMed, DOI )

  38. Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-Ichi Yoshida, Koichi Uemura. Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat. Hepatol. Res.. 2013.05; 43 (5): 526-534. ( PubMed, DOI )

  39. Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells. Brain Res.. 2013.01; 1490 9-22. ( PubMed, DOI )

  40. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida KI, Uemura K. Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res. 2013; ( PubMed, DOI )

  41. Unuma K, Aki T, Funakoshi T, Yoshida K, Uemura K.. Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart. PLoS One.. 2013; 8 (2): e56526. ( DOI )

  42. Noritake K, Aki T, Funakoshi T, Unuma K, Nara A, Kato C, Uemura K. Critical roles of Rho-associated kinase in membrane blebbing and mitochondrial pathway of apoptosis caused by 1-butanol. Toxicol In Vitro. 2012.09; 26 (6): 849-855. ( PubMed, DOI )

  43. Nara A, Aki T, Funakoshi T, Unuma K, Uemura K. Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res. 2012.07; 1466 1-14. ( PubMed, DOI )

  44. Takeshi Funakoshi, Toshihiko Aki, Haruka Nakayama, Yumi Watanuki, Satoko Imori, Koichi Uemura. Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine. Toxicol In Vitro. 2011.12; 25 (8): 1581-1587. ( PubMed, DOI )

  45. Kana Unuma, Kazuki Harada, Takeshi Funakoshi, Koichi Uemura. Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus). Forensic Sci. Int.. 2011.10; 212 (1-3): e15-e17. ( PubMed, DOI )

  46. Noritake K, Unuma K, Nara A, Uchida K, Shiratori T, Watanuki Y, Funakoshi T, Uemura K. Autopsy findings of a patient with rapidly progressive massive ascites caused by alcoholic cirrhosis. Legal Medicine (Tokyo). 2011; 13 (3): 148-150. ( PubMed, DOI )

  47. Nara A, Aki T, Funakoshi T, Uemura K. Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells. Brain Res. 2010.09; 1352 1-10. ( PubMed, DOI )

  48. Aki T, Nara A, Funakoshi T, Uemura K. Bifurcate effects of glucose on caspase-independent cell death during hypoxia. Biochem Biophys Res Commun. 2010.06; 396 (3): 614-618. ( PubMed, DOI )

  49. Nara A, Aki T, Funakoshi T, Uchida K, Nakayama H, Uemura K. Death due to blood transfusion-induced anaphylactic shock: A case report. Leg Med (Tokyo). 2010.05; 12 (3): 148-150. ( PubMed, DOI )

  50. Toshihiko Aki, Takeshi Funakoshi, Junko Nishida-Kitayama, Yoichi Mizukami. TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. J. Cell. Physiol.. 2008.10; 217 (1): 194-206. ( PubMed, DOI )

  51. Takao Hirata, Ying Jun Cui, Takeshi Funakoshi, Yoichi Mizukami, Yu-Ichiro Ishikawa, Futoshi Shibasaki, Mishiya Matsumoto, Takefumi Sakabe. The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Brain Res.. 2007.01; 1130 (1): 214-222. ( PubMed, DOI )

  52. Takeshi Funakoshi, Akie Yanai, Koh Shinoda, Michio M Kawano, Yoichi Mizukami. G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem. Biophys. Res. Commun.. 2006.08; 346 (3): 904-910. ( PubMed, DOI )

  53. Toshihiko Utsumi, Kengo Nakano, Takeshi Funakoshi, Yoshiyuki Kayano, Sayaka Nakao, Nagisa Sakurai, Hiroyuki Iwata, Rumi Ishisaka. Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation. Eur. J. Biochem.. 2004.02; 271 (4): 863-874. ( PubMed )

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Books etc 【 display / non-display 】

  1. Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.. Comprehensive Toxicology 3rd ed Volume 1. Elsevier UK， 2018 Modes of Chemically Induced Cell Death. (ISBN : 9780081006016)

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Conference Activities & Talks 【 display / non-display 】

  1. 小松美結,船越丈司,上村公一. アリストロキア酸による近位尿細管急性毒性とDNA損傷の検討. 第46回日本分子生物学会年会 2023.12 神戸

  2. Minegishi S, Ishii N, Utuno H, Noritake K, Funakoshi T, Uemura K, Sakuma A, Saitoh H, Ohtani S, Sakurada K.. Preparation of dentin standard samples for age estimation based on increased aspartic acid racemization rate with overheating.. 第102次日本法医学術全国集会 2018.06.07 福岡

  3. Funakoshi-Hirose I, Funakoshi T, Kojima H, Saka K, Uemura K. Sudden death after inhalation of synthetic cannabinoids. 9th International Symposium on Advances in Legal Medicine 2014.06

  4. Yamada A, Funakoshi T, Komatsu A, Aihara Y, Uchida K, Uemura K. An autopsy case of severe hyponatremia suspected to be caused by polydipsia.. 9th International Symposium on Advances in Legal Medicine 2014.06

  5. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of ubiquitin-proteasome system plays a protective role in arsenic trioxide-induced cardiotoxicity. 9th International Symposium on Advances in Legal Medicine 2014.06

  6. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura. Secretion of mitochondrial contents through autophagolysosomal exocytosis from lipopolysaccharide-stimulated hepatocytes and embryonic fibroblasts.. 9th International Symposium on Advances in Legal Medicine 2014.06 Fukuoka,Japan

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