Yan BC, Adachi T, Tsubata T. ER stress is involved in B cell antigen receptor ligation-induced apoptosis. Biochem Biophys Res Commun. 2008.01; 365 (1): 143-148. ( PubMed, DOI )

Zhu C, Sato M, Yanagisawa T, Fujimoto M, Adachi T, Tsubata T. Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen. J Biol Chem. 2008.01; 283 (3): 1653-1659. ( PubMed, DOI )

Adachi T, Wienands J, Tsubata T, Kurosaki T. Interdomain A is crucial for ITAM-dependent and -independent regulation of Syk. Biochem Biophys Res Commun. 2007.12; 364 (1): 111-117. ( PubMed, DOI )

Yu J, Sawada T, Adachi T, Gao X, Takematsu H, Kozutsumi Y, Ishida H, Kiso M, Tsubata T. Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. Biochem Biophys Res Commun. 2007.09; 360 (4): 759-764. ( PubMed, DOI )

Sato M, Adachi T, Tsubata T. Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. J Immunol. 2007.03; 178 (5): 2901-2907. ( PubMed, DOI )

Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K. Bispecific abs against modified protein and DNA with oxidized lipids. Proc Natl Acad Sci U S A. 2006.04; 103 (16): 6160-6165. ( PubMed, DOI )

Hirai H, Adachi T, Tsubata T. Involvement of cell cycle progression in survival signaling through CD40 in the B-lymphocyte line WEHI-231. Cell Death Differ. 2004.03; 11 (3): 261-269. ( PubMed, DOI )

Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T. Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells. J Immunol. 2003.08; 171 (4): 1835-1843. ( PubMed, DOI )

Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003.03; 4 (3): 274-279. ( PubMed, DOI )

Wakabayashi C, Adachi T, Wienands J, Tsubata T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science. 2002.12; 298 (5602): 2392-2395. ( PubMed, DOI )

Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001.07; 276 (28): 26648-26655. ( PubMed, DOI )

Adachi T, Wakabayashi C, Nakayama T, Yakura H, Tsubata T. CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol. 2000.02; 164 (3): 1223-1229. ( PubMed, DOI )

Hagiyama H, Adachi T, Yoshida T, Nomura T, Miyasaka N, Honjo T, Tsubata T. Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis. Oncogene. 1999.07; 18 (28): 4091-4098. ( PubMed, DOI )

Hotta H, Aoki N, Matsuda T, Adachi T. Molecular analysis of a novel protein kinase in maturing rice seed. Gene. 1998.06; 213 (1-2): 47-54. ( PubMed )

Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 1998.05; 160 (10): 4662-4665. ( PubMed )

Nakase M, Usui Y, Alvarez-Nakase AM, Adachi T, Urisu A, Nakamura R, Aoki N, Kitajima K, Matsuda T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy. 1998; 53 (46 Suppl): 55-57. ( PubMed )

Aoki N, Ishii T, Ohira S, Yamaguchi Y, Negi M, Adachi T, Nakamura R, Matsuda T. Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. Biochim Biophys Acta. 1997.03; 1334 (2-3): 182-190. ( PubMed )

Nakase M, Aoki N, Matsuda T, Adachi T. Characterization of a novel rice bZIP protein which binds to the alpha-globulin promoter. Plant Mol Biol. 1997.02; 33 (3): 513-522. ( PubMed )

Adachi T, Ahn JY, Yamamoto K, Aoki N, Nakamura R, Matsuda T. Characterization of the bovine kappa-casein gene promoter. Biosci Biotechnol Biochem. 1996.12; 60 (12): 1937-1940. ( PubMed )

Nakase M, Yamada T, Kira T, Yamaguchi J, Aoki N, Nakamura R, Matsuda T, Adachi T. The same nuclear proteins bind to the 5'-flanking regions of genes for the rice seed storage protein: 16 kDa albumin, 13 kDa prolamin and type II glutelin. Plant Mol Biol. 1996.11; 32 (4): 621-630. ( PubMed )

Tada Y, Nakase M, Adachi T, Nakamura R, Shimada H, Takahashi M, Fujimura T, Matsuda T. Reduction of 14-16 kDa allergenic proteins in transgenic rice plants by antisense gene. FEBS Lett. 1996.08; 391 (3): 341-345. ( PubMed )

Nakase M, Alvarez AM, Adachi T, Aoki N, Nakamura R, Matsuda T. Immunochemical and biochemical identification of the rice seed protein encoded by cDNA clone A3-12. Biosci Biotechnol Biochem. 1996.06; 60 (6): 1031-1032. ( PubMed )

Nakase M, Hotta H, Adachi T, Aoki N, Nakamura R, Masumura T, Tanaka K, Matsuda T. Cloning of the rice seed alpha-globulin-encoding gene: sequence similarity of the 5'-flanking region to those of the genes encoding wheat high-molecular-weight glutenin and barley D hordein. Gene. 1996.05; 170 (2): 223-226. ( PubMed )

Adachi T, Schamel WW, Kim KM, Watanabe T, Becker B, Nielsen PJ, Reth M. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. EMBO J. 1996.04; 15 (7): 1534-1541. ( PubMed )

Aoki N, Kishi M, Taniguchi Y, Adachi T, Nakamura R, Matsuda T. Molecular cloning of glycoprotein antigens MGP57/53 recognized by monoclonal antibodies raised against bovine milk fat globule membrane. Biochim Biophys Acta. 1995.12; 1245 (3): 385-391. ( PubMed )

Ishii T, Aoki N, Noda A, Adachi T, Nakamura R, Matsuda T. Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Biochim Biophys Acta. 1995.12; 1245 (3): 285-292. ( PubMed )

Alvarez AM, Adachi T, Nakase M, Aoki N, Nakamura R, Matsuda T. Classification of rice allergenic protein cDNAs belonging to the alpha-amylase/trypsin inhibitor gene family. Biochim Biophys Acta. 1995.09; 1251 (2): 201-204. ( PubMed )

Alvarez AM, Fukuhara E, Nakase M, Adachi T, Aoki N, Nakamura R, Matsuda T. Four rice seed cDNA clones belonging to the alpha-amylase/trypsin inhibitor gene family encode potential rice allergens. Biosci Biotechnol Biochem. 1995.07; 59 (7): 1304-1308. ( PubMed )

Yamamura J, Adachi T, Aoki N, Nakajima H, Nakamura R, Matsuda T. Precursor-product relationship between chicken vitellogenin and the yolk proteins: the 40 kDa yolk plasma glycoprotein is derived from the C-terminal cysteine-rich domain of vitellogenin II. Biochim Biophys Acta. 1995.06; 1244 (2-3): 384-394. ( PubMed )

Apel TW, Scherer A, Adachi T, Auch D, Ayane M, Reth M. The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa. Gene. 1995.04; 156 (2): 191-197. ( PubMed )

Ahn JY, Aoki N, Adachi T, Mizuno Y, Nakamura R, Matsuda T. Isolation and culture of bovine mammary epithelial cells and establishment of gene transfection conditions in the cells. Biosci Biotechnol Biochem. 1995.01; 59 (1): 59-64. ( PubMed )

Kim KM, Adachi T, Nielsen PJ, Terashima M, Lamers MC, Kohler G, Reth M. Two new proteins preferentially associated with membrane immunoglobulin D. EMBO J. 1994.08; 13 (16): 3793-3800. ( PubMed )

Terashima M, Kim KM, Adachi T, Nielsen PJ, Reth M, Kohler G, Lamers MC. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO J. 1994.08; 13 (16): 3782-3792. ( PubMed )

Aoki N, Kuroda H, Urabe M, Taniguchi Y, Adachi T, Nakamura R, Matsuda T. Production and characterization of monoclonal antibodies directed against bovine milk fat globule membrane (MFGM). Biochim Biophys Acta. 1994.01; 1199 (1): 87-95. ( PubMed )

Adachi T, Izumi H, Yamada T, Tanaka K, Takeuchi S, Nakamura R, Matsuda T. Gene structure and expression of rice seed allergenic proteins belonging to the alpha-amylase/trypsin inhibitor family. Plant Mol Biol. 1993.01; 21 (2): 239-248. ( PubMed )

Izumi H, Adachi T, Fujii N, Matsuda T, Nakamura R, Tanaka K, Urisu A, Kurosawa Y. Nucleotide sequence of a cDNA clone encoding a major allergenic protein in rice seeds. Homology of the deduced amino acid sequence with members of alpha-amylase/trypsin inhibitor family. FEBS Lett. 1992.05; 302 (3): 213-216. ( PubMed )

Adachi T, Yamagata H, Tsukagoshi N, Udaka S. Repression of the cell wall protein gene operon in Bacillus brevis 47 by magnesium and calcium ions. J Bacteriol. 1991.07; 173 (13): 4243-4245. ( PubMed )

Adachi T, Sakakibara T, Yamagata H, Tsukagoshi N, Udaka S. Analysis by deletion and site-directed mutagenesis of promoters of the cell wall protein gene operon in Bacillus brevis 47. Agric Biol Chem. 1991.01; 55 (1): 189-194. ( PubMed )

Adachi T, Yamagata H, Tsukagoshi N, Udaka S. Use of both translation initiation sites of the middle wall protein gene in Bacillus brevis 47. J Bacteriol. 1990.01; 172 (1): 511-513. ( PubMed )

Adachi T, Yamagata H, Tsukagoshi N, Udaka S. Multiple and tandemly arranged promoters of the cell wall protein gene operon in Bacillus brevis 47. J Bacteriol. 1989.02; 171 (2): 1010-1016. ( PubMed )

Tsuboi A, Uchihi R, Adachi T, Sasaki T, Hayakawa S, Yamagata H, Tsukagoshi N, Udaka S. Characterization of the genes for the hexagonally arranged surface layer proteins in protein-producing Bacillus brevis 47: complete nucleotide sequence of the middle wall protein gene. J Bacteriol. 1988.02; 170 (2): 935-945. ( PubMed )

Yamagata H, Adachi T, Tsuboi A, Takao M, Sasaki T, Tsukagoshi N, Udaka S. Cloning and characterization of the 5' region of the cell wall protein gene operon in Bacillus brevis 47. J Bacteriol. 1987.03; 169 (3): 1239-1245. ( PubMed )

Kawamoto S, Uemura K, Hori N, Takayasu L, Konishi Y, Katoh K, Matsumoto T, Suzuki M, Sakai Y, Matsudaira T, Adachi T, Ohtani N, Standley DM, Suda W, Fukuda S, Hara E. Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota. Nature cell biology. 2023.06; 25 (6): 865-876. ( PubMed, DOI )

Takeuchi Y, Fukunaga M, Iwatani S, Miyanaga K, Adachi T, Yamamoto N. Release of an anti-anxiety peptide in casein hydrolysate with Aspergillus oryzae protease. Food & function. 2022.10; 13 (20): 10449-10460. ( PubMed, DOI )

Hirata Y, Nomura K, Kato D, Tachibana Y, Niikura T, Uchiyama K, Hosooka T, Fukui T, Oe K, Kuroda R, Hara Y, Adachi T, Shibasaki K, Wake H, Ogawa W. A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy. The Journal of clinical investigation. 2022.05; 132 (10): 1-13. ( PubMed, DOI )

Gao P, Adachi T, Okai S, Morita N, Kitamura D, Shinkura R. Integrin CD11b provides a new marker of pre-germinal center IgA+ B cells in murine Peyer's patches. International immunology. 2022.04; 34 (5): 249-262. ( PubMed, DOI )

Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2022.03; 71 (3): 487-496. ( PubMed, DOI )

Kotake K, Kumazawa T, Nakamura K, Shimizu Y, Ayabe T, Adachi T. Ingestion of miso regulates immunological robustness in mice. PloS one. 2022; 17 (1): e0261680. ( PubMed, DOI )

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PloS one. 2022; 17 (4): e0267473. ( PubMed, DOI )

Tsugawa N, Yamada D, Watabe T, Onizawa M, Wang S, Nemoto Y, Oshima S, Tsubata T, Adachi T, Kawano Y, Watanabe M, Blumberg RS, Okamoto R, Nagaishi T. Corrigendum to "CEACAM1 specifically suppresses B cell receptor signaling-mediated activation". Biochemical and biophysical research communications. 2021.08; 565 97. ( PubMed, DOI )

Yokoi Y, Adachi T, Sugimoto R, Kikuchi M, Ayabe T, Nakamura K. Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method. Biochemical and biophysical research communications. 2021.03; 545 14-19. ( PubMed, DOI )

Tsugawa N, Yamada D, Watabe T, Onizawa M, Wang S, Nemoto Y, Oshima S, Tsubata T, Adachi T, Kawano Y, Watanabe M, Blumberg RS, Okamoto R, Nagaishi T. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochemical and biophysical research communications. 2021.01; 535 99-105. ( PubMed, DOI )

Endo R, Uchiyama K, Lim SY, Itakura M, Adachi T, Uchida K. Recognition of acrolein-specific epitopes by B cell receptors triggers an innate immune response. The Journal of biological chemistry. 2021.01; 296 100648. ( PubMed, DOI )

Yasuda,K., Nakashima,A., Murata,A., Suzuki,K., Adachi,T. Euglena gracilis and β-glucan paramylon induce Ca2+ signaling in intestinal tract epithelial, immune, and neural cells. Nutrients. 2020.07; 12 (8): 2293. ( PubMed, DOI )

Isobe, J., Maeda, S., Obata, Y., Iizuka, K., Nakamura, Y., Fujimura, Y., Kimizuka, T., Hattori, K., Kim, Y-G., Morita, T., Kimura, I., Offermanns, S., Adachi, T., Nakao, A., Kiyono, H., Takahashi, D., Hase, K. Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon. International Immunology. 2020.04; 32 (4): 243-258. ( DOI )

Nishimura, Y., Fukuda, Y., Okonogi, T., Yoshikawa, S., Karasuyama, H., Osakabe, N., Ikegaya, Y., Sasaki, T., Adachi, T.. Dual real-time in vivo monitoring system of the brain-gut axis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.04; 524 (2): 340-345. ( DOI )

Aihara, Y., Fukuda, Y., Takizawa, A., Osakabe, N., Aida, T., Tanaka, K., Yoshikawa, S., Karasuyama, H., Adachi, T. Visualization of mechanical stress-mediated Ca(2+) signaling in the gut using intravital imaging. Bioscience of Microbiota, Food and Health. 2020; 39 (4): 209-18.

Kumazawa, T., Kotake, K., Nishimura, A., Asai, N., Ugajin, T., Yokozeki, H., Adachi, T.. Isolation of food-derived bacteria inducing interleukin-22 in B cells BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2020; 39 (1): 1-9. ( DOI )

Aihara Y, Fukuda Y, Takizawa A, Osakabe N, Aida T, Tanaka K, Yoshikawa S, Karasuyama H, Adachi T. Visualization of mechanical stress-mediated Ca²⁺ signaling in the gut using intravital imaging. Bioscience of microbiota, food and health. 2020; 39 (4): 209-218. ( PubMed, DOI )

Yoshikawa S., Oh-hora M., Hashimoto R., Miyake K., Adachi T., Kawano Y., Yamanishi Y., Kamiya A., Karasuyama H.. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

Yoshikawa S, Oh-hora M, Hashimoto R, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Kamiya A, Karasuyama H. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

Fujii Yasuyuki, Suzuki Kenta, Adachi Takahiro, Taira Shu, Osakabe Naomi. Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (-)-epicatechin tetramer JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION. 2019.07; 65 (1): 29-33. ( DOI )

Yoshikawa Soichiro, Oh-hora Masatsugu, Hashimoto Ryota, Nagao Toshihisa, Peters Louis, Egawa Mayumi, Ohta Takuya, Miyake Kensuke, Adachi Takahiro, Kawano Yohei, Yamanishi Yoshinori, Karasuyama Hajime. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils SCIENCE SIGNALING. 2019.04; 12 (576): ( DOI )

Isobe, J., Maeda, S., Obata, Y., Iizuka, K., Nakamura, Y., Fujimura, Y., Kimizuka, T., Hattori, K., Kim, YG., Morita, T., Kimura, I., Offermanns, S., Adachi, T., Nakao, A., Kiyono, H., Takahashi, D., Hase, K.. Commensal-bacteria-derived butyrate promotes the T cell-independent IgA response in the colon. Int Immunol.. 2019; dxz078. ( DOI )

Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko. Propolis induces Ca2+ signaling in immune cells BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2019; 38 (4): 141-149. ( DOI )

Nagaishi Takashi, Watabe Taro, Hosoya Akinori, Nisha Jose, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. Verification of Intestinal Microflora-Mediated Mucosal Homeostasis by Immunoglobulin A DIGESTION. 2019; 99 (1): 109.

Nagaishi Takashi, Watabe Taro, Hosoya Akinori, Nisha Jose, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. Verification of Intestinal Microflora-Mediated Mucosal Homeostasis by Immunoglobulin A DIGESTION. 2019; 99 (1): 109.

Kumazawa T, Nishimura A, Asai N, Adachi T. Isolation of immune-regulatory Tetragenococcus halophilus from miso. PLOS ONE. 2018.12; 13 (12): e0208821 . ( DOI )

Jin K, Imada T, Nakamura S, Izuta Y, Oonishi E, Shibuya M, Sakaguchi H, Adachi T, Tsubota K. Intravital Two-photon Imaging of Ca 2+ signaling in Secretory Organs of Yellow Cameleon Transgenic Mice. Scientific reports. 2018.10; 8 (1): 15880. ( PubMed, DOI )

Fujii Y, Suzuki K, Hasegawa Y, Nanba F, Toda T, Adachi T, Taira S, Osakabe N. Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus. Neuroscience letters . 2018.08; 682 106-111. ( DOI )

Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. Immunity. 2018.07; 49 (1): 120-133.e9. ( DOI )

Watabe T, Nagaishi T, Tsugawa N, Kojima Y, Jose N, Hosoya A, Onizawa M, Nemoto Y, Oshima S, Nakamura T, Karasuyama H, Adachi T, Watanabe M. B cell activation in the cecal patches during the development of an experimental colitis model. Biochemical and biophysical research communications. 2018.01; 496 (2): 367-373. ( DOI )

Nakagawa Y, Ishimura K, Oya S, Kamino M, Fujii Y, Nanba F, Toda T, Ishii T, Adachi T, Suhara Y, Osakabe N. Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice. PloS one. 2018; 13 (7): e0201203. ( PubMed, DOI )

Tabakawa Y, Ohta T, Yoshikawa S, Robinson EJ, Yamaji K, Ishiwata K, Kawano Y, Miyake K, Yamanishi Y, Ohtsu H, Adachi T, Watanabe N, Kanuka H, Karasuyama H. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Frontiers in immunology. 2018; 9 1540. ( PubMed, DOI )

Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E.

Miyashita Satoshi, Adachi Toma, Yamashita Mariko, Sota Takayuki, Hoshino Mikio. Dynamics of the cell division orientation of granule cell precursors during cerebellar development MECHANISMS OF DEVELOPMENT. 2017.10; 147 1-7. ( DOI )

Toshihiro Imada, Jin Kai, Izuta Yusuke, Nakamura Shigeru, Adachi Takahiro, Tsubota Kazuo. In vivo dynamics of Ca2+-dependent myoepithelial contraction in lacrimal gland INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017.06; 58 (8):

Toshihiro Imada, Jin Kai, Izuta Yusuke, Nakamura Shigeru, Adachi Takahiro, Tsubota Kazuo. In vivo dynamics of Ca2+-dependent myoepithelial contraction in lacrimal gland INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017.06; 58 (8):

Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. THE LACK OF SECRETED IGA SPONTANEOUSLY INDUCES THE MUCOSAL INFLAMMATION SPECIFICALLY IN THE ILEUM GASTROENTEROLOGY. 2017.04; 152 (5): S1004.

THE LACK OF SECRETED IGA SPONTANEOUSLY INDUCES THE MUCOSAL INFLAMMATION SPECIFICALLY IN THE ILEUM 2017.04; 152 (5): S1004.

Akatsu C, Shinagawa K, Numoto N, Liu Z, Ucar AK, Aslam M, Phoon S, Adachi T, Furukawa K, Ito N, Tsubata T. CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. The Journal of experimental medicine. 2016.11; 213 (12): 2691-2706. ( PubMed, DOI )

S. Yoshikawa, M. Oh-hora, T. Adachi, Y. Yamanishi, H. Karasuyama. Stromal interaction molecule-1/2 plays essential role in basophil activation and development of IgE-mediated chronic allergic inflammation EUROPEAN JOURNAL OF IMMUNOLOGY. 2016.08; 46 99.

Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T. . Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep.. 2016.01; 6 (18738): ( DOI )

Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T. Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Scientific reports. 2016.01; 6 18738. ( PubMed, DOI )

Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, Hazato N, Miyawaki A, Yoshikawa S, Usami T, Karasuyama H, Kimoto-Nira H, Hirayama K, Tsuji NM.. Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo. Front Immunol.. 2016; 7 (601): ( DOI )

Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, Hazato N, Miyawaki A, Yoshikawa S, Usami T, Karasuyama H, Kimoto-Nira H, Hirayama K, Tsuji NM. Visualization of Probiotic-Mediated Ca²⁺ Signaling in Intestinal Epithelial Cells <i>In Vivo</i>. Frontiers in immunology. 2016; 7 601. ( PubMed, DOI )

Xu Miduo, Hou Rong, Sato-Hayashizaki Aya, Man Rongyong, Zhu Chenghua, Wakabayashi Chisato, Hirose Sachiko, Adachi Takahiro, Tsubata Takeshi. Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol. 2013.06; 190 (11): 5436-5445. ( PubMed, DOI )

Harumiya Satoru, Yoshino Aya, Hayashizaki Koji, Mizuno Kazuya, Yakura Hidetaka, Adachi Takahiro. A system for reconstructing B cell antigen receptor signaling in the mouse myeloma J558L cell line. Arch Biochem Biophys. 2013.05; 533 (1-2): 18-24. ( PubMed, DOI )

Adachi Takahiro, Harumiya Satoru, Takematsu Hiromu, Kozutsumi Yasunori, Wabl Matthias, Fujimoto Manabu, Tedder Thomas F. CD22 serves as a receptor for soluble IgM. Eur J Immunol. 2012.01; 42 (1): 241-247. ( PubMed, DOI )

Hitomi Yuki, Adachi Takahiro, Tsuchiya Naoyuki, Honda Zen-Ichiro, Tokunaga Katsushi, Tsubata Takeshi. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol. 2012; 13 72. ( PubMed, DOI )

Urano S, Kaneko C, Nei T, Motoi N, Tazawa R, Watanabe M, Tomita M, Adachi T, Kanazawa H, Nakata K. A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodies. Journal of immunological methods. 2010.08; 360 (1-2): 141-8. ( PubMed, DOI )

Manabu Fujimoto, Nobuko Ishiura, Takahiro Adachi, Takeshi Tsubata, Thomas F. Tedder, Kunihiko Tamaki. Distinctive tyrosine phosphorylation pattern of CD19 during BCR and CD40 signaling FASEB JOURNAL. 2008.04; 22

Fujimoto Manabu, Ishiura Nobuko, Adachi Takahiro, Tsubata Takeshi, Tedder Thomas F., Tamaki Kunihiko. Distinctive tyrosine phosphorylation pattern of CD19 during BCR and CD40 signaling FASEB JOURNAL. 2008.04; 22

Chenghua Zhu, Motohiko Sato, Teruhiko Yanagisawa, Manabu Fujimoto, Takahiro Adachi, Takeshi Tsubata. Novel binding site for Src Homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen (vol 283, pg 1653, 2008) JOURNAL OF BIOLOGICAL CHEMISTRY. 2008.02; 283 (9): 5972.

Sato Motohiko, Adachi Takahiro, Tsubata Takeshi. Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation JOURNAL OF IMMUNOLOGY. 2007.03; 178 (5): 2901-2907.

Singh Savita Devi, Hiroyuki Hagiyama, Takahiro Adachi, Nobuyuki Miyasaka, Takeshi Tsubata. The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes Signal Transduction. 2006.02; 6 (1): 54-61. ( DOI )

Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T. Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells JOURNAL OF IMMUNOLOGY. 2003.08; 171 (4): 1835-1843.

Wakabayashi C, Adachi T, Wienands R, Tsubata T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor SCIENCE. 2002.12; 298 (5602): 2392-2395.

Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates JOURNAL OF BIOLOGICAL CHEMISTRY. 2001.07; 276 (28): 26648-26655.

T Tsubata, C Wakabayashi, T Adachi. Regulation of B-cell antigen receptor signaling by CD72 ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS. 2001; 123-128.

Adachi T, Wakabayashi C, Nakayama T, Yakura H, Tsubata T. CD72 negatively regulates signaling through the antigen receptor of B cells JOURNAL OF IMMUNOLOGY. 2000.02; 164 (3): 1223-1229.

Hagiyama H, Adachi T, Yoshida T, Nomura T, Miyasaka N, Honjo T, Tsubata T. Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis ONCOGENE. 1999.07; 18 (28): 4091-4098.

Y Takeuchi, K Nishimura, N Aoki, T Adachi, C Sato, K Kitajima, T Matsuda. A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida - Its first identification, cDNA cloning and granulosa cell-specific expression EUROPEAN JOURNAL OF BIOCHEMISTRY. 1999.03; 260 (3): 736-742. ( PubMed, DOI )

CY Wu, T Adachi, T Hatano, H Washida, A Suzuki, F Takaiwa. Promoters of rice seed storage protein genes direct endosperm-specific gene expression in transgenic rice PLANT AND CELL PHYSIOLOGY. 1998.08; 39 (8): 885-889.

Wu CY, Adachi T, Hatano T, Washida H, Suzuki A, Takaiwa F. Promoters of rice seed storage protein genes direct endosperm-specific gene expression in transgenic rice PLANT AND CELL PHYSIOLOGY. 1998.08; 39 (8): 885-889.

Hotta H, Aoki N, Matsuda T, Adachi T. Molecular analysis of a novel protein kinase in maturing rice seed GENE. 1998.06; 213 (1-2): 47-54.

Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T. Cutting edge: The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation JOURNAL OF IMMUNOLOGY. 1998.05; 160 (10): 4662-4665.

M Oubihi, K Kitajima, K Kobayashi, T Adachi, N Aoki, T Matsuda. Development of an enzyme-linked immunosorbent assay-based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate ANALYTICAL BIOCHEMISTRY. 1998.03; 257 (2): 169-175. ( PubMed, DOI )

M Oubihi, K Kitajima, K Kobayashi, T Adachi, N Aoki, T Matsuda. Development of an ELISA based assay for measuring glycosyltransferase activity using synthetic glycopolymers ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 9. 1998; 171-176.

T Adachi, H Flaswinkel, H Yakura, M Reth, T Tsubata. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation 10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2. 1998; 341-344.

Chuan-Yin Wu, Takahiro Adachi, Tetsuya Hatano, Haruhiko Washida, Akihiro Suzuki, Fumio Takaiwa. Promoters of rice seed storage protein genes direct endosperm-specific gene expression in transgenic rice Plant and Cell Physiology. 1998; 39 (8): 885-889. ( DOI )

Tsukasa Matsuda, Masahiro Nakase, Takahiro Adachi, Ryo Nakamura, Yuichi Tada, Hiroaki Shimada, Masayoshi Takahashi, Tasuhito Fujimura. Allergenic proteins in Rice : Strategies for reduction and evaluation G.Eisenbrand, H.Aulepp, A.D.Dayan, P.S.Elias, W.Grunow, J.Ring, J.Schlatter(eds.) Food Allergies and Intolerances, Section III. The Input of Molecular Biology: Transgenic Foods.. 1996; 161-169.

Tsukasa Matsuda, Masahiro Nakase, Takahiro Adachi, Ryo Nakamura, Yuichi Tada, Hiroaki Shimada, Masayoshi Takahashi, Tasuhito Fujimura. Allergenic proteins in Rice : Strategies for reduction and evaluation G.Eisenbrand, H.Aulepp, A.D.Dayan, P.S.Elias, W.Grunow, J.Ring, J.Schlatter(eds.) Food Allergies and Intolerances, Section III. The Input of Molecular Biology: Transgenic Foods.. 1996; 161-169.

Yuichi Tada, Takahiro Adachi, Tsukasa Matsuda, Masayoshi Takahashi, Tasuhito Fujimura, Ryo Nakamura, Hiroaki Shimada. Reduction of allergenic proteins in transgenic rice by antisense strategy K.Oono, F.Takaiwa(eds.), Modification of gene expression and non-mendelian inheritance. National Institute of Agrobiological Resources, Japan. 1995; 313-324.

Yuichi Tada, Takahiro Adachi, Tsukasa Matsuda, Masayoshi Takahashi, Tasuhito Fujimura, Ryo Nakamura, Hiroaki Shimada. Reduction of allergenic proteins in transgenic rice by antisense strategy K.Oono, F.Takaiwa(eds.), Modification of gene expression and non-mendelian inheritance. National Institute of Agrobiological Resources, Japan. 1995; 313-324.

Takahiro Adachi, Angelina M. Alvarez, Naohito Aoki, Ryo Nakamura, Tsukasa Matsuda, Virgilio V. Garcia. Screening of Rice Strains Deficient in 16-kDa Allergenic Protein Bioscience, Biotechnology, and Biochemistry. 1995; 59 (7): 1377-1378. ( DOI )

N AOKI, M UJITA, H KURODA, M URABE, A NODA, T ADACHIL, R NAKAMURA, T MATSUDA. IMMUNOLOGICALLY CROSS-REACTIVE 57 KDA AND 53 KDA GLYCOPROTEIN ANTIGENS OF BOVINE-MILK FAT GLOBULE-MEMBRANE - ISOFORMS WITH DIFFERENT N-LINKED SUGAR CHAINS AND DIFFERENTIAL GLYCOSYLATION AT EARLY STAGES OF LACTATION BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1994.07; 1200 (2): 227-234.

JY AHN, K YAMAMOTO, N AOKI, T ADACHI, R NAKAMURA, T MATSUDA. EXPRESSION OF MILK PROTEIN CAT CHIMERIC GENES IN TRANSFECTED BOVINE AND MOUSE MAMMARY EPITHELIAL CELLS ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 6. 1994; 259-263.

安達貴弘、渡部太郎、永石宇司、渡邉 守、烏山 一、吉川宗一郎. IgA deficiency causes spontaneous enteritis. 第48回日本免疫学会学術集会、浜松 2019.12.13

安達貴弘、渡部太郎、永石宇司、渡邉 守、烏山 一、吉川宗一郎. IgA deficiency causes spontaneous enteritis. 第48回日本免疫学会学術集会、浜松 2019.12.13

Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Toshimitsu Fujii, Yudai Kojima, Arisa Tokai, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe. BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. 第48回日本免疫学会学術集会 2019.12.11 アクトシティ浜松

Fukuda, Y., Osakabe, N., Adachi,, T.. Elucidation of recognition mechanism of dorsal root ganglion for food factors. The international conference on food factors(ICoFF2019) 2019.12.03 Kobe

福田陽大 ,越阪部奈緒美,安達貴弘. Elucidation of recognition mechanism of dorsal root ganglion for food factors. 第9回The international conference on food factors(ICoFF2019) 2019.12.03

福田陽大 ,越阪部奈緒美,安達貴弘. Elucidation of recognition mechanism of dorsal root ganglion for food factors. 第9回The international conference on food factors(ICoFF2019) 2019.12.03

福田陽大 ,越阪部奈緒美,安達貴弘. Elucidation of recognition mechanism of dorsal root ganglion for food factors. 第9回The international conference on food factors(ICoFF2019)、神戸 2019.12.03

Tsugawa Naoya, Nagaishi Takashi, Yamada Daiki, Kojima Yudai, Watabe Taro, Wang Shuang, Onizawa Michio, Adachi Takahiro, Watanabe Mamoru. 寛容と免疫抑制　活性化B細胞におけるBCRシグナル伝達はCeacam1の長いアイソホームにより調節される可能性がある(Tolerance and Immune suppression　BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1). 日本免疫学会総会・学術集会記録 2019.11.01

Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko. プロポリスは免疫細胞におけるCa2+シグナル伝達を誘導する(Propolis induces Ca2+ signaling in immune cells). Bioscience of Microbiota, Food and Health 2019.10.01

Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Analysis of Ileocecal Immune Response in an Animal Model of Colitis. ICMI 2019 2019.07.17 Brisbane Convention & Exhibition Centre(Brisbane)

Fujii Yasuyuki, Suzuki Kenta, Adachi Takahiro, Taira Shu, Osakabe Naomi. (-)-エピカテキン4量体であるシンナムタンニンA2の単回経口投与後にマウスの室傍核で副腎皮質刺激ホルモン放出ホルモンは有意に上方制御される(Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (-)-epicatechin tetramer). Journal of Clinical Biochemistry and Nutrition 2019.07.01

Adachi Takahiro, Karasuyama Hajime, Yoshikawa Soichiro. B細胞　疾患におけるB細胞の役割と調節　免疫細胞におけるCa2+シグナル伝達の動態は免疫疾患の素因と前病的状態を予測する(B cells-2:Roles and regulation of B cells in diseases　Kinetics of Ca2+ signaling in immune cells predict predisposition and pre-pathological conditions of the immune diseases). 日本免疫学会総会・学術集会記録 2018.12.01

Yoshikawa Soichiro, Tabakawa Yuya, Ohta Takuya, Yamaji Kayoko, Ishiwata Kenji, Kawano Yohei, Yamanishi Yoshinori, Ohtsu Hiroshi, Adachi Takahiro, Watanabe Naohiro, Kanuka Hirotaka, Karasuyama Hajime. 肥満細胞と顆粒球　肥満細胞ではなく皮膚浸潤好塩基球から放出されるhistamineはマウスにおいてマダニ抵抗性の獲得に極めて重要である(Mast cells & granulocytes　Histamine released from skin-infiltrating basophils but not mast cells is crucial for acquired tick resistance in mice). 日本免疫学会総会・学術集会記録 2018.12.01

Takashi Nagaishi, Naoya Tsugawa, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A. The 11th International Gastrointestinal Consensus Symposium 2018.02.10 Tokyo

Nagaishi Takashi, Watabe Taro, Hosoya Akinori, Nisha Jose, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. 免疫グロブリンAによる腸細菌叢介在性粘膜ホメオスタシスの検証(Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A). 日本消化管学会雑誌 2018.02.01

Takahiro Adachi. Intravital imaging of cellular signaling in immune cells．The 3rd International Symposium on Stem Cell Traits and Developmental Systems. KEY Forum 2018 2018.01.11 Kumamoto

安達 貴弘. Intravital imaging of cellular signaling in immune cells．. Stem Cell Traits and Developmental Systems．KEY Forum 2018 2018.01.11

安達 貴弘. Intravital imaging of cellular signaling in immune cells．. Stem Cell Traits and Developmental Systems．KEY Forum 2018 2018.01.11

安達 貴弘. Intravital imaging of cellular signaling in immune cells．. Stem Cell Traits and Developmental Systems．KEY Forum 2018、熊本 2018.01.11

Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

安達 貴弘, 吉川 宗一郎, 烏山 一. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice.. The 46th Annual Meeting of The Japanese Society for Immunology,Sendai 2017.12.14

安達 貴弘, 吉川 宗一郎, 烏山 一. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice.. The 46th Annual Meeting of The Japanese Society for Immunology,Sendai 2017.12.14

Tsugawa Naoya, Nagaishi Takashi, Watabe Taro, Jose Nisha, Hosoya Akinori, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 粘膜皮膚免疫(2)　粘膜の細菌叢とホメオスタシスに対する免疫グロブリンAによる制御の検証(Mucosal-Skin Immunity(2)　Verification of immunoglobulin A regulation of mucosal microflora and homeostasis). 日本免疫学会総会・学術集会記録 2017.12.01

Watabe Taro, Nagaishi Takashi, Hosoya Akinori, Jose Nisha, Tsugawa Naoya, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 組織特異的免疫疾患(III)　実験的結腸炎モデルにおける生体内イメージングによる回盲免疫反応の分析(Tissue-specific immune diseases(III)　Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging). 日本免疫学会総会・学術集会記録 2017.12.01

Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Takahiro Adachi, Richard S. Blumberg, Mamoru Watanabe. Verification of Immunoglobulin A regulation of microflora and protection of intestinal mucosa.. UEGW 2017 2017.10.31 Barcelona

Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe.. Deficiency of IgA Induces Microflora Alteration and Ileal Inflammation.. ICMI 2017 2017.07.21 Washington DC

Akinori Hosoya, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A protection of intestinal mucosa from microflora. The 5th Annual Meeting of AOCC 2017.06.17 Seoul

Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe. IgA Deficiency Induces Spontaneous Inflammation in the Ileum. FOCIS 2017 2017.06.14 Chicago

Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum. DDW (AGA) 2017.05.09 Chicago

ADACHI Takahiro, KARASUYAMA Hajime , YOSHIKAWA Soichiro. Visualization of immune responses by intravital imaging of Ca2+ signals. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.07 OKINAWA

TSUJI Noriko M, KAMIYA Tomonori, WATANABE yohei,KAKUTA Shigeru, ADACHI Takahiro. Effects of fermented food on immune response and gut microbiota of human faecal flora-associated (HFA) mice. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.05 OKINAWA

Tsuji Noriko M., Kamiya Tomonori, Watanabe Yohei, Kakuta Shigeru, Adachi Takahiro. ヒト免疫学　正常・疾患時ヒト免疫のモデリング　ヒト糞便フローラ(HFA)マウスの免疫反応および腸内微生物叢に発酵食品が及ぼす効果(Human Immunology: modeling normal and diseased human immunity　Effects of fermented food on immune response and gut microbiota of human faecal flora-associated(HFA) mice). 日本免疫学会総会・学術集会記録 2016.11.01

Watabe Taro, Nagaishi Takashi, Jose Nisha, Tokai Arisa, Hosoya Akinori, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. 皮膚免疫と粘膜免疫1　腸管粘膜免疫応答の制御　マウスのIgA遺伝子座におけるCRISPR/Cas9を介した変異とその特徴(Skin & mucosal immunity: Regulation of intestinal mucosal immune responses　CRISPR/Cas9-mediated mutations in mouse IgA locus and its characterization). 日本免疫学会総会・学術集会記録 2016.11.01

Adachi Takahiro, Karasuyama Hajime, Yoshikawa Soichiro. 免疫記憶　Ca2+シグナルの生体内造影による免疫応答の可視化(Immunological memory　Visualization of immune responses by intravital imaging of Ca2+ signals). 日本免疫学会総会・学術集会記録 2016.11.01

Kai Jin, Toshihiro Imada, Yusuke Izuta, Shigeru Nakamura, Takahiro Adachi, Kazuo Tsubota. IN VIVO VISUALIZATION OF Ca2+ DYNAMICS OF MYOEPITHELIAL CELLS IN LACRIMAL GLAND. 8th International Conference on the　Tea Film & Ocular Surface Basic Science and Clinical Relevance 2016.09.08 FRANCE

Akatsu Chizuru, Aslam Mohammad, Adachi Takahiro, Tsubata Takeshi, Phoon S., Watanabe K., Shinagawa K., Ito N.. B細胞の生物学　CD72とSLE関連抗原の相互作用は自己反応性B細胞を負に調節する(B cell biology　Interaction of CD72 and SLE-related antigen negatively regulates self-reactive B cells). 日本免疫学会総会・学術集会記録 2015.10.01

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime, Onodera Taishi, Takahashi Yoshimasa, Kikuta Junichi, Ishii Masaru, Tedder F. Thomas. 免疫記憶　Ca2+バイオセンサーYC3.60トランスジェニックマウスのリンパ球におけるCa2+シグナルの生体内イメージング(Immunological Memory　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2015.10.01

Tokai Arisa, Nagaishi Takashi, Watabe Taro, Jose Nisha, Yamazaki Motomi, Onizawa Michio, Suzuki Masahiro, Hosoya Akinori, Kawai Risa, Adachi Takahiro, Watanabe Mamoru. 皮膚と粘膜免疫の調節(2)　CD66aは活性化B細胞においてBCRシグナル伝達を調節する(Regulation of skin and mucosal immunity(2)　CD66a may regulate BCR signaling in the activated B cells). 日本免疫学会総会・学術集会記録 2015.10.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Ato Manabu, Takahashi Yoshimasa. 全身性自己免疫性疾患(1)　SLEマウスモデルにおけるフローサイトメトリーによる抗核Ab産生B細胞の可視化(Systemic autoimmune diseases(1)　Visualization of anti-nuclear Ab producing B cells by flow-cytometry in a SLE mouse model). 日本免疫学会総会・学術集会記録 2015.10.01

Aslam Mohammad, Adachi Takahiro, Tsubata Takeshi. 全身性自己免疫性疾患(1)　CD72は核内抗原に対する自己反応性B細胞を制御する(Systemic autoimmune diseases(1)　CD72 regulates self-reactive B cells to nuclear antigens). 日本免疫学会総会・学術集会記録 2015.10.01

Adachi. T., Yoshikawa. S., Onodera. T., Takahashi. Y. and Karasuyama. H.. In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator. The 43rd Annual Meeting of the Japanese Society for Immunology 2014.12.08 Kyoto

Adachi. T., Yoshikawa. S., Onodera. T., Takahashi. Y. and Karasuyma. H.. In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator. The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.26 Yokohama

Adachi Takahiro, Yoshikawa Soichiro, Onodera Taishi, Takahashi Yoshimasa, Karasuyama Hajime. 免疫記憶　遺伝的にコード化されたYC3.60カルシウムインジケーターを発現するマウスのB細胞におけるカルシウムシグナル伝達のin vivo画像化(Immunological memory　In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator). 日本免疫学会総会・学術集会記録 2014.11.01

Yoshikawa Soichiro, Ohora Masatsugu, Miyake Kensuke, Li Lihua, Horiguchi Kayo, Ohta Takuya, Adachi Takahiro, Yamanishi Yoshinori, Karasuyama Hajime. 肥満細胞、好塩基細胞、好中球の細胞型特異的機能の調節機構　好塩基細胞におけるIgE/抗原刺激によるCa2+流入の根底にある分子機構(Regulatory mechanisms of cell type-specific functions of mast cells, basophils, and eosinophils　Molecular mechanism underlying Ca2+ influx due to IgE/antigen stimulation in basophils). 日本免疫学会総会・学術集会記録 2014.11.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Kurosaki Tomohiro, Adachi Yu, Ato Manabu, Takahashi Yoshimasa. 発生中のB細胞調節の機構と免疫応答　インフルエンザワクチン接種後のCD273+免疫記憶B細胞は定常状態にある骨髄形質細胞を補充する(Mechanisms for B cell regulation during development and immune responses　CD273+ memory B cells replenish bone marrow plasma cells in the steady state after influenza vaccination). 日本免疫学会総会・学術集会記録 2014.11.01

Xu Miduo, Hirose Sachiko, Adachi Takahiro, Tsubata Takeshi, Hou Rong, Sato-Hayashizaki Aya, Man Rongyong, Zhu Chenghua, Wakabayashi Chisato. Cd72cはFaslpr誘発性自己免疫疾患を調節する変更遺伝子である(Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease). 日本免疫学会総会・学術集会記録 2013.11.01

Yoshikawa Soichiro, Oh-hora Masatsugu, Miyake Kensuke, Li Lihua, Ohta Takuya, Adachi Takahiro, Horiguchi Kayo, Kawano Yohei, Karasuyama Hajime. STIM1介在性のストア作動性Ca2+流入はIgEによる慢性アレルギー性炎症における好塩基球動員に必須である(STIM1-mediated store operated Ca2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation). 日本免疫学会総会・学術集会記録 2013.11.01

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime, Onodera Taishi. 遺伝的にコード化されたYC3.60カルシウムインジケータを発現するマウスのB細胞におけるカルシウムシグナル伝達のin vivoイメージング(In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator). 日本免疫学会総会・学術集会記録 2013.11.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Kurosaki Tomohiro, Adachi Yu, Ato Manabu, Takahashi Yoshimasa. 長寿命形質細胞の動員は、インフルエンザワクチン接種後の維持期において、CD4+T細胞により恒常的に制限される(Replenishment of Long-Live Plasma Cells is constitutively restricted by CD4+T cells in their maintenance phase after influenza vaccination). 日本免疫学会総会・学術集会記録 2013.11.01

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞活性化制御とシグナル　C型レクチン様ドメインを持つB細胞膜タンパク質CD72はスルファチドを認識し、抗スルファチド抗体産生を制御する(The C-type lectin-like domain containing B lymphocyte membrane protein CD72 recognizes sulfatide and regulates anti-sulfatiide antibody production). 日本免疫学会総会・学術集会記録 2012.11.01

Yoshikawa Soichiro, Egawa Mayumi, Oh-hora Masatsugu, Adachi Takahiro, Horiguchi Kayo, Li Lihua, Ohta Takuya, Kawano Yohei, Minegishi Yoshiyuki, Karasuyama Hajime. 炎症応答におけるマスト細胞と顆粒球の機能　STIM1はIgEを介する慢性アレルギー性炎症時の好塩基球動員において重要な役割を果たす(STIM1 plays an essential role in basophil recruitment during IgE-mediated chronic allergic inflammation). 日本免疫学会総会・学術集会記録 2012.11.01

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime. 記憶T細胞とB細胞　遺伝的にコードされたカルシウム指示分子YC3.60レポーターマウス系におけるB細胞活性のin vivoイメージング(In vivo imaging of B cell activity in a genetically encoded calcium indicator YC3.60 reporter mouse line). 日本免疫学会総会・学術集会記録 2012.11.01

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞免疫反応の制御機構　B細胞特異的C型レクチン様分子CD72の硫酸化糖に対するCa2+非依存性のレクチン活性(The C-type lectin-like domain containing B lymphocyte membrane molecule CD72 shows Ca2+-independent lectin activity to sulfated glycans). 日本免疫学会総会・学術集会記録 2011.11.01

Adachi Takahiro. B細胞免疫記憶　記憶B細胞における抗原受容体を介したシグナリング(Signaling through the antigen receptor on memory B cell). 日本免疫学会総会・学術集会記録 2011.11.01

Matsunaga Syu, Takahashi Ken, Sakuramoto Masateru, Taguchi Jun, Adachi Takahiro, Hashimoto Kahoko. 抗原提示　プロフェッショナル抗原提示細胞におけるSec8分子の機能解析(The functional analysis of Sec8 molecules on professional antigen presenting cells). 日本免疫学会総会・学術集会記録 2011.11.01

Xu Miduo, Hou Rong, Ohtsuji Mareki, Ohtsuji Naomi, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 全身性自己免疫疾患　素因、病態、治療　CD72はB6lpr/lprマウスにおけるループス様疾患の形成を制御する(CD72 modulates the development of lupus-like disease in B6lpr/lpr mice). 日本免疫学会総会・学術集会記録 2009.11.01

Hou Rong, Ohtsuji Mareki, Ohtsuji Naomi, Zhang Li, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 臓器特異的自己免疫疾患　C56BL/6由来の第四染色体セントロメア近傍の遺伝子による糖尿病の亢進(Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice). 日本免疫学会総会・学術集会記録 2009.11.01

Sato Aya, Hou Rong, Lin Qingshun, Ohtsuji Mareki, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 全身性自己免疫疾患　素因、病態、治療　CD72遺伝子多型と自己免疫疾患との関連(Role of CD72 polymorphism for autoimmune disease). 日本免疫学会総会・学術集会記録 2009.11.01

Adachi Takahiro. 記憶細胞の発達と活性化　記憶B細胞における抗原受容体を介したシグナリングの解析(Analysis of signaling through the B cell antigen receptor in memory B cells). 日本免疫学会総会・学術集会記録 2009.11.01

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞分化とその活性化シグナル　B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性(The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose). 日本免疫学会総会・学術集会記録 2008.11.01

渡辺 幸造, 中島 権一, 今井 有香, 安達 貴弘, 佐藤 元彦, 林崎 浩史, 戸谷 希一郎, 伊藤 幸成, 鍔田 武志. B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する(Ca2+ independent lectin activity of C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 for oligomannose). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2008.11.01

Hitomi Yuki, Adachi Takahiro, Iwai Yoshiko, Tsuchiya Naoyuki, Honda Zen-ichiro, Tokunaga Katsushi, Tsubata Takeshi. B細胞分化とその活性化シグナル　SLE抵抗性を有するヒトCD72選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する(Augmentation of ER stress-induced apoptosis by the alternatively spliced isoform of human CD72 responsible for resistance of individuals with CD72*2 to systemic lupus erythematosus). 日本免疫学会総会・学術集会記録 2008.11.01

Adachi Takahiro, Man Rong-Yong, Yakura Hidetaka, Tsubata Takeshi. B細胞分化とその活性化シグナル　CD22による糖鎖リガンド依存的および非依存的なB細胞抗原受容体シグナル伝達制御(Glycan ligand-dependent and -independent regulation of the B cell antigen receptor signaling by CD22). 日本免疫学会総会・学術集会記録 2008.11.01

戸田 宗豊, 圓山 浩二, 万木 肇, 秋田 薫, 井上 瑞江, 竹内 紀子, 安達 貴弘, 鍔田 武志, 中田 博. 腫瘍産生性ムチンとCD22との連鎖反応は脾臓辺縁帯B細胞を劇的に障害する(Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2007.11.01

Zhu Chenghua, Adachi Takahiro, Sato Motohiko, Fujimoto Manabu, Tsubata Takeshi. CD22におけるITIM含有チロシン783とチロシン817を含有するITAMモチーフはBCRシグナル伝達の負制御に十分である(An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling). 日本免疫学会総会・学術集会記録 2007.10.01

Adachi Takahiro, Yu Jie, Onodera Taishi, Man Rong-Yong, Tsubata Takeshi. CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白質抗原が必要である(CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen). 日本免疫学会総会・学術集会記録 2007.10.01

Hitomi Yuki, Adachi Takahiro, Tsuchiya Naoyuki, Honda Zen-ichiro, Tokunaga Katsushi, Tsubata Takeshi. 全身性エリテマトーデスに対する耐性を付与するヒトCD72の選択的スプライシングアイソフォームはB細胞アポトーシスを制御する(The alternative spliced isoform of human CD72 that confer resistant against systemic lupus erythematosus regulate B lymphocyte apoptosis). 日本免疫学会総会・学術集会記録 2007.10.01

Yan Bincheng, Adachi Takahiro, Tsubata Takeshi. 小胞体ストレスがB細胞抗原受容体を介したアポトーシスに関与する(Unfolded protein response is involved in B cell antigen receptor-mediated apoptosis). 日本免疫学会総会・学術集会記録 2007.10.01

Yu Jie, Adachi Takahiro, Gao Xiaoming, Takematsu Hiromu, Tsubata Takeshi. 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害(Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts). 日本免疫学会総会・学術集会記録 2007.10.01

Yu Jie, Adachi Takahiro, Gao Xiaoming, Tsubata Takeshi. B細胞の分化・活性化と情報伝達　B細胞活性化を制御する細胞内シグナル　マウスCD22阻害因子のスクリーニング法の確立(Establishment of the screening for mouse CD22 inhibitors). 日本免疫学会総会・学術集会記録 2006.11.01

Adachi Takahiro, Yan Bincheng, Tsubata Takeshi. アポトーシス　B細胞において細胞周期停止はROS介在性アポトーシスを誘導する(Cell cycle arrest induces ROS-mediated apoptosis in B cells). 日本免疫学会総会・学術集会記録 2006.11.01

Tsubata Takeshi, Yu Jie, Sato Motohiko, Onodera Taishi, Wakabayashi Chisato, Adachi Takahiro. 免疫認識、シグナル伝達、及びイメージング　B細胞表面上のBCR共受容体CD22及びCD72の制御された局在(Immune recognition, signaling and imaging　Regulated localization of BCR co-receptors CD22 and CD72 on the B cell surface). 日本免疫学会総会・学術集会記録 2006.11.01

Sato Motohiko, Wakabayashi Chisato, Hokazono Yasuhisa, Onodera Taishi, Adachi Takahiro, Tsubata Takeshi. siglec2/CD22を介するB細胞抗原受容体信号伝達の免疫グロブリンイソ型依存性調節(Immunoglobulin Isotype-Dependent Regulation of B Cell Antigen Receptor Signaling Mediated by Siglec2/CD22). Trends in Glycoscience and Glycotechnology 2006.08.01

The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling. 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto 2006.06.18

mmunosuppressive effect of mucin on B cell function in tumor-bearing state.. . 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006

安達 貴弘. Screening of the genes related to the cell cycle arrest-induced apoptosis... International Symposium on Life of Proteins 2005.10.30 Awajishi 2005.10.30

Akagawa Mitsugu, Ito Sohei, Takasaki Yoshinari, Hattori Nobutaka, Adachi Takahiro, Matuda Tsukasa, Uchida Koji. タンパク質に結合した脂質過酸化物は全身性紅斑性狼瘡の特徴である抗DNA自己抗体の標的となる(Protein-bound lipid peroxidation products are targeted by anti-DNA autoantibodies, the hallmark of systemic lupus erythematosus). 生化学 2005.08.01

Toda Munetoyo, Takeuchi Noriko, Adachi Takahiro, Nakanishi Katsuyuki, Matsubara Jyunko, Taketani Shigeru, Tsubata Takeshi, Murata Takeomi, Nakada Hiroshi. 担ガン状態におけるB細胞機能に対するムチンの免疫抑制効果(Immunosupressive effect of mucin on B cell function in tumor-bearing state). 生化学 2005.08.01

Satoh Motohiko, Adachi Takahiro, Wakabayashi Chisato, Tsubata Takeshi. 免疫グロブリンアイソタイプの違いによるB細胞反応性の差異におけるSiglec-2/CD22の役割(Role of Siglec-2/CD22 in class-specific regulation of B lymphocyte activation). 生化学 2004.08.01

Wakabayashi Chisato, Adachi Takahiro, Sato Motohito, Hokazono Yasuhisa, Tsubata Takeshi. siglec 2/CD22によるBリンパ球活性化のアイソタイプ特異的調節(Isotype-Specific Regulation of B Lymphocyte Activation by Siglec 2/CD22). Trends in Glycoscience and Glycotechnology 2004.05.01

Adachi Takahiro, Wakabayashi Chisato, Tsubata Takeshi. Bリンパ球活性化のクラス特異性制御におけるSiglec-2/CD22 の役割(Role of Siglec-2/CD22 in class-specific regulation of B lymphocyte activation). 生化学 2003.08.01

Hirai Hiroyuki, Adachi Takahiro, Tsubata Takeshi. CDK阻害剤の発現により誘導されたアポトーシスをc-Mycは制御する(c-Myc regulates apoptosis induced by expression of a CDK inhibitor). 生化学 2003.08.01

Wakabayashi Chisato, Adachi Takahiro, Tsubata Takeshi. 免疫細胞活性化・分化のシグナル伝達とその制御　Immunoglobulin Isotype特異的シグナリング経路を制御するBリンパ球の活性化(Signal transduction regulating activation and differentiation of immune cells: Immunoglobulin isotype-specific signaling pathway regulating B lymphocyte activation). 生化学 2003.08.01

Tsubata Takeshi, Adachi Takahiro, Wakabayashi Chisato, Higuchi Tetsuya, Aiba Yuichi. B細胞に関する共受容体及び補助的刺激受容体による液性免疫反応の調節(Regulation of humoral immune responses by co-receptors and costimulatory receptors on B cells). 日本免疫学会総会・学術集会記録 2001.12.01

Hirai Hiroyuki, Adachi Takahiro, Tsubata Takeshi. サイクリンキナーゼ阻害剤Kip1とc-MycのBリンパ球アポトーシスにおける役割(ROLE OF CKI KIP1 AND C-MYC IN B LYMPHOCYTES APOPTOSIS). Cell Structure and Function 2001.10.01

Tsubata Takeshi, Wakabayashi Chisato, Wienands Juergen, Yakura Hidetaka, Reth Michael, Adachi Takahiro. Bリンパ球の抑制性Co-receptors. 日本免疫学会総会・学術集会記録 1999.10.01