Personnel Information

写真a

MIYAHARA Yuji


Job title

Project Professor

Birth date

1956

Laboratory Address

Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan

Laboratory Phone number

+81-3-5280-8095

Laboratory Fax number

+81-3-5280-8095

Mail Address

miyahara.bsr@tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/bsr/index.html

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Graduating School 【 display / non-display 】

  • Tokyo Institute of Technology, Faculty of Engineering, Physical Electronics, 1980, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Institute of Technology, Graduate School, Division of Science and Engineering, Electrical and Electronics Engineering, Doctor's Course, 1985, Completed

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Degree 【 display / non-display 】

  • Dr. of Engineering, Tokyo Institute of Technology

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Campus Career 【 display / non-display 】

  • 2010.09
    -
    2022.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Medical Devices， Bioelectronics， Professor
  • 2010.09
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Bioelectronics， Professor
  • 2010.09
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Bioelectronics， Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biomedical Engineering Innovation Research Center， Project Professor
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External Career 【 display / non-display 】

  • 1985 Central Research Laboratory, Hitachi Ltd.,
  • 1988-1989 Visiting researcher at Dept. of Organic Chemistry, ETH Zürich,
  • 1994 Senior researcher, Central Research Laboratory, Hitachi Ltd.,
  • 1998 Vice Department manager of Biosystem research department, Central Research Laboratory, Hitachi Ltd.,
  • 2000 Senior researcher, Biomedical Center, Hitachi High-technologies,
  • 2002 Director of Bioelectronics group, National Institute for Materials Science,
  • 2006 - 2009,
  • Professor, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo,
  • 2008 - 2010.8,
  • Managing Director, Biomaterials Center, NIMS,
  • Principal Investigator, MANA, NIMS,
  • 2008 - present,
  • Visiting professor at Research Institute for Nanodevice and Bio Systems, Hiroshima University,
  • 2010.9 - present,
  • Professor at Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University,

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Academic Activity 【 display / non-display 】

  • 2001 Oct., Member of the International Federation of Clinical Chemistry (IFCC) Working Group on Nanotechnology
  • 2002 Oct., Sub-committee chair, 2002 International Conference on Solid State Devices and Materials
  • 2002 May, Local Organizing Committee, 6th International Conference on Miniaturized Chemical and Biochemical Analysis System (μTAS2002)
  • 2003 Jan., 2003, Sub-committee chair, International Conference on Solid State Devices and Materials
  • 2003 Jan., Organizing committee, International Symposium on Fusion of Nano- and Bio- Technologies
  • 2003. Nov. - 2004. Oct. Session chair at 2004 International Microprocesses and Nanotechnology Conference
  • 2004 Jan., Sub-committee chair, 2004 International Conference on Solid State Devices and Materials
  • 2004. Nov. - 2005. Oct., Session chair at 2005 International Microprocesses and Nanotechnology Conference
  • 2005 May, 4th International Conference on Microtechnologies in Medicine and Biology, Program Chair (MMB 2005)
  • 2005. Nov. - 2006. Oct., Session chair at 2006 International Microprocesses and Nanotechnology Conference (MNC 2006)
  • 2006. Nov. - 2007. Oct., Session chair at 2007 International Microprocesses and Nanotechnology Conference (MNC 2007)

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Research Areas 【 display / non-display 】

  • Nanomaterials

  • Biomedical engineering

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Research Theme 【 display / non-display 】

  • An interdisciplinary area is explored and developed by integrating materials science and biological science. Novel biocompatible materials and functional bio-devices are developed for regenerative medicine, cell therapy, minimum-invasive surgery and clinical diagnostics. In the group of Yuji Miyahara, direct interaction between biomolecules and carriers in semiconductor materials has recently been investigated. For this purpose, an insulated gate field effect transistor (IGFET) has been used in combination with functional membranes. ,,The FET is one of the most important and fundamental devices in the integrated circuit. In the case of FET type biochemical sensors, species to be detected and its selectivity can be determined by the materials coated on the surface of the gate insulator. Ion sensors, biosensors and oxygen sensor have been developed using polymer membranes, immobilized enzyme membranes and a solid electrolyte thin film, respectively. ,,Recently, we have been investigating electrostatic detection of bio-molecular recognition using a biologically coupled field effect transistor (bio-FET). The principle of bio-FET is based on potentiometric detection of charge density change which is induced at a gate insulator/solution interface by specific bio-molecular recognition. In this scheme, the charge density change is directly transduced into electrical signal by the field effect. Based on this principle, various types of bio-FETs have been developed for detection of biomolecules

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Published Papers & Misc 【 display / non-display 】

  1. Chindanai Ratanaporncharoen, Miyuki Tabata, Natthapol Watanagool, Tatsuro Goda. Characterization and Optimization of Thermally Grown Iridium Oxide and Its Application to pH Sensors Sensors and Materials. 2018.05; 30 (5): 1175-1185. ( DOI )

  2. Yukichi, Horiguchi, Tatsuro, Goda, Yuji, Miyahara. Simple functionalization method for single conical pores with a polydopamine layer. Applied Physics Express. 2018.04; 11 (4): 047001. ( DOI )

  3. Chindanai Ratanaporncharoen, Miyuki Tabata, Yuichi Kitasako, Masaomi Ikeda, Tatsuro Goda, Akira Matsumoto, Junji Tagami, Yuji Miyahara. pH Mapping on Tooth Surfaces for Quantitative Caries Diagnosis Using Micro Ir/IrOx pH Sensor. Anal. Chem.. 2018.03; ( PubMed, DOI )

  4. Enrico Tenaglia, Yuki Imaizumi, Yuji Miyahara, Carlotta Guiducci. Isothermal Multiple Displacement Amplification of DNA Templates in Minimally Buffered Conditions using Phi29 Polymerase Chemical Communications. 2018.02; 17 (57): 2158-2161. ( DOI )

  5. Yukichi Horiguchi, Tatsuro Goda, Akira Matsumoto, Hiroaki Takeuchi, Shoji Yamaoka, Yuji Miyahara. Direct and Label-Free Influenza Virus Detection Based on Multisite Binding to Sialic Acid Receptors Biosens. Bioelectron.. 2017.06; 92 234-240.

  6. Wenfeng Hai, Tatsuro Goda, Hiroaki Takeuchi, Shoji Yamaoka, Yukichi Horiguchi, Akira Matsumoto, Yuji Miyahara. Specific Recognition of Human Influenza Virus with PEDOT Bearing Sialic Acid-Terminated Trisaccharides ACS Appl. Mater. Interfaces. 2017.04; 9 14162-14170.

  7. Akira Matsumoto, Shohei Sato, Tomoko Sakamaki, Mai Sanjo, Miyuki Tabata, Tatsuro Goda, Taka-aki Asoh, Akihiko Kikuchi, Yuji Miyahara. Demonstration of Thermo-Sensitive Tetra-Gel with Implication for Facile and Versatile Platform for a New Class of Smart Gels J. Biomater. Sci. Polym. Ed.. 2017.04; 28 1000-1009.

  8. Yuki Imaizumi, Tatsuro Goda, Daniel F. Schaffhauser, Jun-ichi Okada, Akira Matsumoto, Yuji Miyahara. Proton-Sensing Transistor Systems for Detecting Ion Leakage from Plasma Membranes under Chemical Stimuli Acta Biomater.. 2017.03; 50 502-509.

  9. Tatsuro Goda, Yuji Miyahara. Calcium-Independent Binding of Human C-Reactive Protein to Lysophosphatidylcholine in Supported Planar Phospholipid Monolayers Acta Biomater.. 2017.01; 48 206-214. ( DOI )

  10. Miyuki Tabata, Chindanai Ratanaporncharoen, Aoi Asano, Yuichi Kitasako, Masaomi Ikeda, Tatsuro Goda, Akira Matsumoto, Junji Tagami, Yuji Miyahara. Miniaturized Ir/IrOx pH Sensor for Quantitative Diagnosis of Dental Caries Procedia Eng.. 2016.11; 168 ( DOI )

  11. Miyuki Tabata, Yurika Katayama, Fahmida Mannan, Ayaka Seichi, Koji Suzuki, Tatsuro Goda, Akira Matsumoto, Yuji Miyahara. Label-free and Electrochemial Detection of Nucleic Acids Based on Isothermal Amplification in Combination with Solid-state pH Sensor Procedia Eng.. 2016.11; 168 419-422. ( DOI )

  12. Tatsuro Goda, Yuji Miyahara. Engineered Zwitterionic Phosphorylcholine Monolayers for Elucidating Multivalent Binding Kinetics of C-reactive Protein Acta Biomater.. 2016.08; 40 46-53. ( DOI )

  13. Yuki Imaizumi, Tatsuro Goda, Yutaro Toya, Akira Matsumoto, Yuichi Miyahara. Oleyl Group-functionalized Insulating Gate Transistors for Measuring Extracellular pH of Floating Cells Sci. Technol. Adv. Mater.. 2016.07; 17 337-345. ( DOI )

  14. Daniel Schaffhauser, Michael Fine, Miyuki Tabata, Tatsuro Goda, Yuji Miyahara. Measurement of Rapid Amiloride-Dependent pH Changes at the Cell Surface Using a Proton-Sensitive Field-Effect Transistor Biosensors. 2016.03; 6 (2): 11. ( DOI )

  15. Ayaka Seichi, Nanami Kozuka, Yuko Kashima, Miyuki Tabata, Tatsuro Goda, Akira Matsumoto, Naoko Iwasawa, Daniel Citterio, Yuji Miyahara, Koji Suzuki. Real-time Monitoring and Detection of Primer Generation-Rolling Circle Amplification of DNA using an Ethidium Ion-Selective Electrode Anal. Sci.. 2016.03; 32 (5): 505-510. ( DOI )

  16. Tatsuro Goda, Eriko Yamada, Yurika Katayama, Miyuki Tabata, Akira Matsumoto, Yuji Miyahara. Potentiometric responses of ion-selective microelectrode with bovine serum albumin adsorption Biosensors and Bioelectronics. 2016.03; 77 208-214. ( DOI )

  17. Akira Matsumoto, Mai Yuasa, Mai Sanjo, Miyuki Tabata, Tatsuro Goda, Toru Hoshi, Takao Aoyagi, Yuji Miyahara. Boronate Functionalized Polymer Gel Based Insulin Delivery System with Improved Stability in Performance: A Comparative Structure-Function Study 2016.02; 45 (4): 460-462. ( DOI )

  18. Tatsuro Goda, Masahiro Toya, Akira Matsumoto, Yuji Miyahara. Poly(3,4-ethylenedioxythiophene) bearing phosphorylcholine groups for metal-free, antibody-free, and low-impedance biosensors sspecific for C-reactive protein ACS Applied Materials and Interfaces. 2015.11; 7 (49): 27440-27448. ( DOI )

  19. Tatsuro Goda, Daiki Higashi, Akira Matsumoto, Toru Hoshi, Takashi Sawaguchi, Yuji Miyahara. Dual aptamer-immobilized surfaces for improved affinity through multiple target binding in potentiometric thrombin biosensing Biosensors and Bioelectronics. 2015.11; 73 174-180. ( DOI )

  20. Tatsuro Goda, Kazuhiko Ishihara, Yuji Miyahara. Critical Update on 2-Methacryloyloxyethyl Phosphorylcholine (MPC) Polymer Science Journal of Applied Polymer Science. 2015.01; 132 (16): 41766. ( DOI )

  21. Mai Sanjoh, Daisuke Iizuka, Akira Matsumoto, Yuji Miyahara. Boronate Based Metal-Free Platform for Diphosphate-Specific Molecular Recognitions. Org Lett. 2015.01; 17 (3): 588-591. ( PubMed, DOI )

  22. Tatsuro Goda, Peter Kjall, Kazuhiko Ishihara, Agneta Richter-Dahlfors and Yuji Miyahara,. Biomimetic interfaces reveal activation dynamics of C-reactive protein in local microenvironments. Adv Healthc Mater. 2014.11; 3 (11): 1733-1738. ( PubMed, DOI )

  23. Bo Yao, Yichen Liu, Miyuki Tabata, Huangtianzhi Zhu and Yuji Miyahara. Sensitive detection of microRNA by chronocoulometry and rolling circle amplification on a gold electrode. Chem Commun . 2014.09; 50 (68): 9704-9706. ( PubMed, DOI )

  24. Matsumoto Akira, Miyahara Yuji. Current and emerging challenges of field effect transistor based bio-sensing. Nanoscale. 2013.11; 5 (22): 10702-10718. ( PubMed, DOI )

  25. Goda Tatsuro, Tabata Miyuki, Sanjoh Mai, Uchimura Mai, Iwasaki Yasuhiko, Miyahara Yuji. Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform. Chem Commun (Camb). 2013.10; 49 (77): 8683-8685. ( PubMed, DOI )

  26. Deshayes Stephanie, Cabral Horacio, Ishii Takehiko, Miura Yutaka, Kobayashi Shutaro, Yamashita Takashi, Matsumoto Akira, Miyahara Yuji, Nishiyama Nobuhiro, Kataoka Kazunori. Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors. J Am Chem Soc. 2013.10; 135 (41): 15501-15507. ( PubMed, DOI )

  27. Matsumoto Akira, Matsumoto Hiroko, Maeda Yasuhiro, Miyahara Yuji. Simple and robust strategy for potentiometric detection of glucose using fluorinated phenylboronic acid self-assembled monolayer. Biochim Biophys Acta. 2013.09; 1830 (9): 4359-4364. ( PubMed, DOI )

  28. Goda Tatsuro, Miyahara Yuji. Label-free and reagent-less protein biosensing using aptamer-modified extended-gate field-effect transistors. Biosens Bioelectron. 2013.07; 45 89-94. ( PubMed, DOI )

  29. Goda Tatsuro, Singi Ankit Balram, Maeda Yasuhiro, Matsumoto Akira, Torimura Masaki, Aoki Hiroshi, Miyahara Yuji. Label-free potentiometry for detecting DNA hybridization using peptide nucleic acid and DNA probes. Sensors (Basel). 2013; 13 (2): 2267-2278. ( PubMed, DOI )

  30. Goda Tatsuro, Masuno Kozue, Nishida Junko, Kosaka Nobuyoshi, Ochiya Takahiro, Matsumoto Akira, Miyahara Yuji. A label-free electrical detection of exosomal microRNAs using microelectrode array. Chem Commun (Camb). 2012.12; 48 (98): 11942-11944. ( PubMed, DOI )

  31. Naito Mitsuru, Ishii Takehiko, Matsumoto Akira, Miyata Kanjiro, Miyahara Yuji, Kataoka Kazunori. A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA. Angew Chem Int Ed Engl. 2012.10; 51 (43): 10751-10755. ( PubMed, DOI )

  32. Goda Tatsuro, Miyahara Yuji. Interpretation of protein adsorption through its intrinsic electric charges: a comparative study using a field-effect transistor, surface plasmon resonance, and quartz crystal microbalance. Langmuir. 2012.10; 28 (41): 14730-14738. ( PubMed, DOI )

  33. Goda Tatsuro, Maeda Yasuhiro, Miyahara Yuji. Simultaneous monitoring of protein adsorption kinetics using a quartz crystal microbalance and field-effect transistor integrated device. Anal Chem. 2012.09; 84 (17): 7308-7314. ( PubMed, DOI )

  34. Matsumoto Akira, Ishii Takehiko, Nishida Junko, Matsumoto Hiroko, Kataoka Kazunori, Miyahara Yuji. A synthetic approach toward a self-regulated insulin delivery system. Angew Chem Int Ed Engl. 2012.02; 51 (9): 2124-2128. ( PubMed, DOI )

  35. Goda Tatsuro, Miyahara Yuji. A hairpin DNA aptamer coupled with groove binders as a smart switch for a field-effect transistor biosensor. Biosens Bioelectron. 2012.02; 32 (1): 244-249. ( PubMed, DOI )

  36. Maeda Yasuhiro, Matsumoto Akira, Miura Yoshiko, Miyahara Yuji. Preparation of alpha-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor. Nanoscale Res Lett. 2012; 7 108. ( PubMed, DOI )

  37. Schaffhauser Daniel Felix, Patti Monica, Goda Tatsuro, Miyahara Yuji, Forster Ian Cameron, Dittrich Petra Stephanie. An integrated field-effect microdevice for monitoring membrane transport in Xenopus laevis oocytes via lateral proton diffusion. PLoS One. 2012; 7 (7): e39238. ( PubMed, DOI )

  38. Goda Tatsuro, Miyahara Yuji. Thermo-responsive molecular switches for ATP using hairpin DNA aptamers. Biosens Bioelectron. 2011.05; 26 (9): 3949-3952. ( PubMed, DOI )

  39. Bonanni Alessandra, Pumera Martin, Miyahara Yuji. Influence of gold nanoparticle size (2-50 nm) upon its electrochemical behavior: an electrochemical impedance spectroscopic and voltammetric study. Phys Chem Chem Phys. 2011.03; 13 (11): 4980-4986. ( PubMed, DOI )

  40. Goda T, Miyahara Y. Molecularly Engineered Charge-Conversion of Proteins for Sensitive Biosensing Anal Chem. 2010.11; 82 (21): 8946-8953.

  41. Sasaki Shigeo, Okabe Satoshi, Miyahara Yuji. Thermodynamic properties of N-isopropylacrylamide in water: solubility transition, phase separation of supersaturated solution, and glass formation. J Phys Chem B. 2010.11; 114 (46): 14995-15002. ( PubMed, DOI )

  42. Kataoka-Hamai C, Higuchi M, Iwai H, Miyahara Y. Detergent-Mediated Formation of Polymer-Supported Phospholipid Bilayers Langmuir. 2010.09; 26 (18): 14600-14605.

  43. Fortina P, Kricka LJ, Bonnell D, Kulkarni A, Wang J, Miyahara Y, Ure D. Nanotechnology: Improving Clinical Testing? Clin Chem. 2010.09; 56 (9): 1384-1389.

  44. Matsumoto Akira, Cabral Horacio, Sato Naoko, Kataoka Kazunori, Miyahara Yuji. Assessment of tumor metastasis by the direct determination of cell-membrane sialic acid expression. Angew Chem Int Ed Engl. 2010.07; 49 (32): 5494-5497. ( PubMed, DOI )

  45. Kataoka-Hamai C, Miyahara Y. Field-effect detection using phospholipid membranes Science and Technology of Advanced Materials. 2010.06; 11 (3):

  46. Bonanni A, Pumera M, Miyahara Y. Rapid, Sensitive, and Label-Free Impedimetric Detection of a Single-Nucleotide Polymorphism Correlated to Kidney Disease Anal Chem. 2010.05; 82 (9): 3772-3779.

  47. Matsumoto Akira, Yamamoto Kazuya, Yoshida Ryo, Kataoka Kazunori, Aoyagi Takao, Miyahara Yuji. A totally synthetic glucose responsive gel operating in physiological aqueous conditions. Chem Commun (Camb). 2010.04; 46 (13): 2203-2205. ( PubMed, DOI )

  48. Goda T, Miyahara Y. Detection of Microenvironmental Changes Induced by Protein Adsorption onto Self-Assembled Monolayers using an Extended Gate-Field Effect Transistor Anal Chem. 2010.03; 82 (5): 1803-1810.

  49. Matsumoto A, Yamamoto K, Yoshida R, Kataoka K, Aoyagi T, Miyahara Y. A totally synthetic glucose responsive gel operating in physiological aqueous conditions Chem Commun. 2010; 46 (13): 2203-2205.

  50. Kataoka-Hamai C, Miyahara Y. Mechanisms of supported bilayer detection using field-effect devices Analyst. 2010; 135 (1): 189-194.

  51. Matsumoto A, Cabral H, Sato N, Kataoka K, Miyahara Y. Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression Angew Chem Int Edit. 2010; 49 (32): 5494-5497.

  52. Matsumoto A, Sato N, Sakata T, Yoshida R, Kataoka K, Miyahara Y. Chemical-to-Electrical-Signal Transduction Synchronized with Smart Gel Volume Phase Transition Adv Mater. 2009.11; 21 (43): 4372-+.

  53. Ihara M, Sakata T, Makino I, Miyahara Y, Ueda H. Open sandwich-based immuno-transistor for label-free and highly sensitive detection of low molecular weight antigens J Biosci Bioeng. 2009.11; 108 S158.

  54. Pumera M, Miyahara Y. What amount of metallic impurities in carbon nanotubes is small enough not to dominate their redox properties? Nanoscale. 2009.11; 1 (2): 260-265.

  55. Pumera M, Iwai H, Miyahara Y. Germanium-oxide-coated carbon nanotubes Nanotechnology. 2009.10; 20 (42):

  56. Matsumoto Akira, Endo Takashi, Yoshida Ryo, Miyahara Yuji. Electrical visualization of chemo-mechanical signal transduction using a smart gel-modified gate field effect transistor. Chem Commun (Camb). 2009.10; (37): 5609-5611. ( PubMed, DOI )

  57. Pumera Martin, Scipioni Roberto, Iwai Hideo, Ohno Takahisa, Miyahara Yuji, Boero Mauro. A mechanism of adsorption of beta-nicotinamide adenine dinucleotide on graphene sheets: experiment and theory. Chemistry. 2009.10; 15 (41): 10851-10856. ( PubMed, DOI )

  58. Pumera Martin, Iwai Hideo, Miyahara Yuji. Germanium-oxide-coated carbon nanotubes. Nanotechnology. 2009.10; 20 (42): 425606. ( PubMed, DOI )

  59. Matsumoto A, Sato N, Kataoka K, Miyahara Y. Noninvasive Sialic Acid Detection at Cell Membrane by Using Phenylboronic Acid Modified Self-Assembled Monolayer Gold Electrode J Am Chem Soc. 2009.09; 131 (34): 12022-+.

  60. Sakata T, Ihara M, Makino I, Miyahara Y, Ueda H. Open Sandwich-Based Immuno-Transistor for Label-Free and Noncompetitive Detection of Low Molecular Weight Antigen Anal Chem. 2009.09; 81 (18): 7532-7537.

  61. Matsumoto Akira, Sato Naoko, Kataoka Kazunori, Miyahara Yuji. Noninvasive sialic acid detection at cell membrane by using phenylboronic acid modified self-assembled monolayer gold electrode. J Am Chem Soc. 2009.09; 131 (34): 12022-12023. ( PubMed, DOI )

  62. Pumera M, Iwai H, Miyahara Y. Bimetallic Nickel-Iron Impurities within Single-Walled Carbon Nanotubes Exhibit Redox Activity towards the Oxidation of Amino Acids Chemphyschem. 2009.08; 10 (11): 1770-1773.

  63. Matsumoto A, Sato N, Miyahara Y. Label free carbohydrate detection by using phenylboronic acid gate-modified field effect transistor Current Applied Physics. 2009.07; 9 (4): E214-E217.

  64. Sakata T, Miyahara Y. Charged nanosphere-coupled biotransistor for highly sensitive genetic analysis Current Applied Physics. 2009.07; 9 (4): E210-E213.

  65. Hulme JP, An SSA, Goddard N, Miyahara Y, Oki A. Fabrication of a flexible multi-referenced surface plasmon sensor using room temperature nanoimprint lithography Current Applied Physics. 2009.03; 9 (2): E185-E188.

  66. Matsumoto A, Sato N, Sakata T, Kataoka K, Miyahara Y. Glucose-sensitive field effect transistor using totally synthetic compounds J Solid State Electr. 2009.01; 13 (1): 165-170.

  67. Matsumoto A, Endo T, Yoshida R, Miyahara Y. Electrical visualization of chemo-mechanical signal transduction using a smart gel-modified gate field effect transistor Chem Commun. 2009; (37): 5609-5611.

  68. Pumera M, Scipioni R, Iwai H, Ohno T, Miyahara Y, Boero M. A Mechanism of Adsorption of beta-Nicotinamide Adenine Dinucleotide on Graphene Sheets: Experiment and Theory Chemistry-a European Journal. 2009; 15 (41): 10851-10856.

  69. Kataoka-Hamai C, Inoue H, Miyahara Y. Detection of supported lipid bilayers using their electric charge Langmuir. 2008.09; 24 (17): 9916-9920.

  70. Sakata T, Miyahara Y. Noninvasive monitoring of transporter-substrate interaction at cell membrane Anal Chem. 2008.03; 80 (5): 1493-1496.

  71. Miyahara Yuji, Nishimura Emi, Sugimura Takashi. Unusual condensation of 3-Thia[5](1,1')ferrocenophane-1,5-dione with glyoxal. Formation of [1.1](2,3)thiopheno(1,1')ferrocenophane-1,7-dione. J Org Chem. 2008.03; 73 (5): 1783-1786. ( PubMed, DOI )

  72. Sakata T, Miyahara Y. Detection of molecular charges at cell membrane Japanese Journal of Applied Physics. 2008.01; 47 (1): 368-370.

  73. Sakata T, Makino I, Kita S, Miyahara Y. Electrical detection of ovum membrane charges using biotransistor Microelectron Eng. 2008; 85 (5-6): 1337-1340.

  74. Sakata T, Ueda A, Miyahara Y. Cell adhesion characteristics of chemically modified silicon nitride surfaces Ieej Transactions on Electrical and Electronic Engineering. 2007.05; 2 (3): 295-300.

  75. Sakata T, Miyahara Y. Direct transduction of allele-specific primer extension into electrical signal using genetic field effect transistor Biosensors & Bioelectronics. 2007.02; 22 (7): 1311-1316.

  76. Sakata T, Maruyama S, Ueda A, Otsuka H, Miyahara Y. Stable immobilization of an oligonucleotide probe on a gold substrate using tripodal thiol derivatives Langmuir. 2007.02; 23 (5): 2269-2272.

  77. Sakata Toshiya, Miyahara Yuji. Direct transduction of allele-specific primer extension into electrical signal using genetic field effect transistor. Biosens Bioelectron. 2007.02; 22 (7): 1311-1316. ( PubMed, DOI )

  78. Room Eva-Ingrid, Kutt Agnes, Kaljurand Ivari, Koppel Ivar, Leito Ivo, Koppel Ilmar A, Mishima Masaaki, Goto Kenta, Miyahara Yuji. Bronsted basicities of diamines in the gas phase, acetonitrile, and tetrahydrofuran. Chemistry. 2007; 13 (27): 7631-7643. ( PubMed, DOI )

  79. Miyahara Yuji. A new general route to thiophenophanes: synthesis and properties of [n](2,5)thiophenophane-1,n-diones. J Org Chem. 2006.08; 71 (17): 6516-6521. ( PubMed, DOI )

  80. Sakata Toshiya, Miyahara Yuji. DNA sequencing based on intrinsic molecular charges. Angew Chem Int Ed Engl. 2006.03; 45 (14): 2225-2228. ( PubMed, DOI )

  81. Hulme JP, Gwak J, Miyahara Y. Biomolecular embossing J Am Chem Soc. 2006.01; 128 (2): 390-391.

  82. Sakata T, Miyahara Y. DNA sequencing based on intrinsic molecular charges Angew Chem Int Edit. 2006; 45 (14): 2225-2228.

  83. Miyahara Y, Sakata T. Electrical Detection of Bio-molecular Recognition Using Insulated Gate Field Effect Transistors Hyomen Kagaku. 2006; 27 (1): 13-20. ( DOI )

  84. Sakata T, Miyahara Y. Detection of DNA recognition events using multi-well field effect devices Biosensors & Bioelectronics. 2005.11; 21 (5): 827-832.

  85. Sakata Toshiya, Miyahara Yuji. Detection of DNA recognition events using multi-well field effect devices. Biosens Bioelectron. 2005.11; 21 (5): 827-832. ( PubMed, DOI )

  86. Sakata T, Miyahara Y. Potentiometric detection of single nucleotide polymorphism by using a genetic field-effect transistor Chembiochem. 2005.04; 6 (4): 703-710.

  87. Sakata T, Kamahori M, Miyahara Y. DNA analysis chip based on field-effect transistors Japanese Journal of Applied Physics Part 1-Regular Papers Brief Communications & Review Papers. 2005.04; 44 (4B): 2854-2859.

  88. Sakata T, Matsumoto S, Nakajima Y, Miyahara Y. Potential behavior of biochemically modified gold electrode for extended-gate field-effect transistor Japanese Journal of Applied Physics Part 1-Regular Papers Brief Communications & Review Papers. 2005.04; 44 (4B): 2860-2863.

  89. Sakata T, Kamahori M, Miyahara Y. Immobilization of oligonucleotide probes on Si3N4 surface and its application to genetic field effect transistor Materials Science & Engineering C-Biomimetic and Supramolecular Systems. 2004.12; 24 (6-8): 827-832.

  90. Ozawa S, Sugano K, Sonehara T, Fukuzono S, Ichikawa A, Fukayama N, Taylor M, Miyahara Y, Irie T. High resolution for single-strand conformation polymorphism analysis by capillary electrophoresis Anal Chem. 2004.10; 76 (20): 6122-6129.

  91. Miyahara Yuji, Goto Kenta, Oka Masakazu, Inazu Takahiko. Remarkably facile ring-size control in macrocyclization: synthesis of hemicucurbit[6]uril and hemicucurbit[12]uril. Angew Chem Int Ed Engl. 2004.09; 43 (38): 5019-5022. ( PubMed, DOI )

  92. Kajiyama T, Miyahara Y, Kricka LJ, Wilding P, Graves DJ, Surrey S, Fortina P. Genotyping on a thermal gradient DNA chip Genome Res. 2003.03; 13 (3): 467-475.

  93. Miyahara Yuji, Abe Kazuaki, Inazu Takahiko. "Molecular" molecular sieves: lid-free decamethylcucurbit[5]uril absorbs and desorbs gases selectively. Angew Chem Int Ed Engl. 2002.08; 41 (16): 3020-3023. ( PubMed, DOI )

  94. Kajiyama T, Tomita H, Miyahara Y. Manipulation of micro air bubbles in a flow-through cell using US standing waves IEEJ Transactions on Sensors and Micromachines. 1999.10; 119 (10): 464-469.

  95. Miyahara Y. Intelligent and Micro Ion Sensors IEEJ Transactions on Sensors and Micromachines. 1998.12; 118 (12): 548-551.

  96. Fujii T, Miyahara Y. Infrared ATR spectroscopy of substrates in aqueous solution using cryoenrichment and its application in enzyme-activity assays Appl Spectrosc. 1998.01; 52 (1): 128-133.

  97. Fujii T, Miyahara Y, Watanabe Y. Highly sensitive biochemical analysis using low-temperature infrared spectroscopy measurements Appl Spectrosc. 1997.11; 51 (11): 1682-1686.

  98. Fujii T, Miyahara Y. Simultaneous Analyses of Biochemical Components in Blood Using Infrared Spectroscopy Combined with Partial Least Squares IEEJ Transactions on Sensors and Micromachines. 1997.05; 117 (6): 332-337.

  99. Lee Geunsu, Oka Masakazu, Takemura Hiroyuki, Miyahara Yuji, Shimizu Nobujiro, Inazu Takahiko. Efficient Synthesis of 2,11,20-Triaza[3.3.3](2,6)pyridinophane. J Org Chem. 1996.11; 61 (23): 8304-8306. ( PubMed )

  100. Miyahara Y, Yamashita K, Ozawa S, Watanabe Y. Shift and drift of electromotive forces of solid-state electrodes with ion-selective liquid membranes Anal Chim Acta. 1996.09; 331 (1-2): 85-95.

  101. Miyahara Y. I. Integrated Biochemical Sensors IEEJ Transactions on Electronics, Information and Systems. 1996.07; 116 (8): 880-882.

  102. Fujii T, Miyahara Y, Watanabe Y. Reduction of Glucose Interference in Biochemical Analyses Based on Infrared-Spectroscopy Bunseki Kagaku. 1995.06; 44 (6): 465-469.

  103. Miyahara Y, Tsukada K, Watanabe Y. Long-Life Planar Oxygen Sensor Sensor Actuat B-Chem. 1994.06; 20 (2-3): 89-94.

  104. Miyahara Y. Characterization of Sputtered Yttria-Stabilized Zirconia Thin-Film and Its Application to a Metal-Insulator-Semiconductor Structure J Appl Phys. 1992.03; 71 (5): 2309-2314.

  105. Miyahara Y, Tsukada K, Miyagi H, Simon W. Urea Sensor Based on an Ammonium-Ion-Sensitive Field-Effect Transistor Sensor Actuat B-Chem. 1991.04; 3 (4): 287-293.

  106. Miyahara Y, Simon W. Comparative-Studies between Ion-Selective Field-Effect Transistors and Ion-Selective Electrodes with Polymeric Membranes Electroanalysis. 1991; 3 (4-5): 287-292.

  107. Tsukada K, Miyahara Y, Shibata Y, Miyagi H. An Integrated Chemical Sensor with Multiple Ion and Gas Sensors Sensor Actuat B-Chem. 1990.10; 2 (4): 291-295.

  108. Durselen LFJ, Oesterle U, Schuppisser S, Pham HV, Miyahara Y, Morf WE, Simon W. New Solid-State Contact for Ion-Selective Liquid Membrane Electrodes Chimia. 1990.06; 44 (6): 214-215.

  109. Manz A, Miyahara Y, Miura J, Watanabe Y, Miyagi H, Sato K. Design of an Open-Tubular Column Liquid Chromatograph Using Silicon Chip Technology Sensor Actuat B-Chem. 1990.01; 1 (1-6): 249-255.

  110. Tsukada K, Miyahara Y, Miyagi H. Platinum-Platinum Oxide Gate Ph Isfet Japanese Journal of Applied Physics Part 1-Regular Papers Short Notes & Review Papers. 1989.12; 28 (12): 2450-2453.

  111. Tsukada K, Sebata M, Miyahara Y, Miyagi H. Long-Life Multiple-Isfets with Polymeric Gates Sensors and Actuators. 1989.07; 18 (3-4): 329-336.

  112. Miyahara Y, Tsukada K, Miyagi H. Field-Effect Transistor Using a Solid Electrolyte as a New Oxygen Sensor J Appl Phys. 1988.04; 63 (7): 2431-2434.

  113. Teravaninthorn U, Miyahara Y, Moriizumi T. The Suitability of Ta2o5 as a Solid-State Ion-Sensitive Membrane Japanese Journal of Applied Physics Part 1-Regular Papers Short Notes & Review Papers. 1987.12; 26 (12): 2116-2120.

  114. Teravaninthorn U, Miyahara Y, Moriizumi T. Influence of Reactive Gas-Pressure on the Properties of Thin-Film Ta2o5 Japanese Journal of Applied Physics Part 1-Regular Papers Short Notes & Review Papers. 1987.03; 26 (3): 347-351.

  115. Miyahara Y. Biochemical FET Journal of the Society of Instrument and Control Engineers. 1986.11; 25 (11): 996-997.

  116. Moriizumi T, Miyahara Y. Proceeding to Biological-Systems .1. Application of Sensors to Biological-Systems Denki Kagaku. 1986.06; 54 (6): 454-458.

  117. Moriizumi T, Miyahara Y, Shiokawa S. Biosensor OYOBUTURI. 1985.02; 54 (2): 98-114.

  118. Miyahara Y, Moriizumi T, Ichimura K. Integrated Enzyme Fets for Simultaneous Detections of Urea and Glucose Sensors and Actuators. 1985; 7 (1): 1-10.

  119. Miyahara Y, Moriizumi T, Shiokawa S, Matsuoka H, Karube I, Suzuki S. Micro Urea Sensor Using Semiconductor and Enzyme Immobilizing Technologies Nippon Kagaku Kaishi. 1983; (6): 823-830.

  120. Matsuoka H, Karube I, Kawana Y, Suzuki S, Miyahara Y, Moriizumi T. Semiconductor Biosensor Modeled on Taste Cell Denki Kagaku. 1982; 50 (10): 856-857.

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Conference Activities & Talks 【 display / non-display 】

  1. Yuji Miyahara. Medical and dental applications of solid-state electrochemical sensors. 3rd Japan-Thailand Joint Symposium on Advanced Nanomaterials and Devices for Electronics and Photonics (JT-AND 2018) 2018.01.22 Chulalongkorn University, Bangkok, Thailand

  2. Yuji Miyahara, Miyuki Tabata, Chindanai Ratanaporncharoen, Aoi Asano, Yuichi Kitasako, Masaomi Ikeda, Tatsuro Goda, Akira Matsumoto, Junji Tagami. Fabrication of needle type pH sensor for quantitative caries detection. European Advanced Materials Congress 2017 2017.08.22 Stockholm, Sweden

  3. Yuji Miyahara. Functional gate-field effect transistors for electrically neutral molecules. Matrafured 2017 2017.06.13 Thermal Hotel Visegrad Superior, Budapest, Hungary

  4. Yuji Miyahara. Exploring Fusion between Life Science and Electronics. 1st International Symposium on Precision Medicine and Biomedical Technologies 2017.06.03 Carp City Hotel, Quanzhou, China

  5. Miyahara Y. Semiconductor devices for biomedical applications. The 3 rd Joint Symposium between IBB/TMDU and Chulalongkorn University on “Biomedical Materials and Engineering” 2016.12.15 Bangkok, Thai

  6. Miyahara Y. Detection of biomolecular recognition using bio-transistors. International Symposium on Biomedical Engineering 2016.11.11 Tokyo,Japan

  7. Naito M, Yoshinaga N, Ishii T, Matsumoto A, Miyahara Y, Miyata K, Kataoka K. Intracellular ATP-responsive release of siRNA from polyion complex micelles. 13th US-Japan Symposium on Drug Delivery Systems 2015.12.16 Hawaii, USA

  8. Miyahara Y. Detection of Biomolecular Recognition and Cell Functions using Biotransistors. The 7th Takayanagi Kenjiro Memorial Symposium 2015.11.18 Shizuoka University

  9. Miyahara Yuji. Detection of Biomolecular Recognition using Bio-transistors.. The 7th International Symposium on Surface Science (ISSS-7) 2014.11.02 Matsue,Japan

  10. Miyahara Yuji. Cell-based Field Effect Transistor for Functional Analyses of Cell Membrane. Matrafured international Conference on Electrochemical Sensors 2014 2014.06.19 Budapest, Hungary

  11. Miyahara Y, Matsumoto A, Goda T, Maeda Y, Tabata M, Sanjoh M. Detection of Biomolecular Recognition Using Bio-Transistor. PITTCON2014 2014.03.02 Chicago,USA

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Patents 【 display / non-display 】

  • DRUG DELIVERY DEVICE

    Patent Number： CN ZL201680072480.X

  • DRUG DELIVERY DEVICE

    Patent Number： US11141486

  • Phenylboronic acid monomer and phenylboronic acid polymer

    Patent Number： 5622188

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Awards & Honors 【 display / non-display 】

  • The Yamazaki Teiichi Prize, Foundation for Promotion of Material Science and Technology of Japan (2006)，2006

  • The Prize of Progress, The Institute of Electrical Engineers of Japan (2005)，2005

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Others 【 display / non-display 】

  • Transistors help identify cancer cell markers，2022.10

  • A lightning-fast flu virus detector，2017.05

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Campus class subject 【 display / non-display 】

  • Bio-intelligence Science

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