Personnel Information

写真a

KANAI Masami


Job title

Professor

Homepage URL

http://www.tmd-cea.jp/eam/

Research Areas, Keywords

Experimental Animal Model for Human Disease

Field Introduction URL

疾患モデル動物解析学分野

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Graduating School 【 display / non-display 】

  • Osaka Prefecture University, Faculty of Agriculture, Veterinary Sciene, 1988, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Agricultural Science, Veterinary Sciene, Doctor's Course, 1992.03, Completed

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Degree 【 display / non-display 】

  • PhD, The University of Tokyo

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Campus Career 【 display / non-display 】

  • 2010.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Experimental Animal Model for Human Disease， Professor
  • 2010.04
    -
    2014.09
    Tokyo Medical and Dental University， Joint Institutes for Education and Research， Center for Experimental Animal， Ceter for Experimental Animals， Professor
  • 2014.10
    -
    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Experimental Animal， Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Professor
  • 2017.05
    -
    2019.08
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Professor
  • 2019.09
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Professor
  • 2020.10
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Center for Experimental Animals， Professor

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Research Areas 【 display / non-display 】

  • Anatomy

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Published Papers & Misc 【 display / non-display 】

  1. Nanae Miyazaki, Shohei Takami, Mami Uemura, Hironobu Oiki, Masataka Takahashi, Hiroshi Kawashima, Yutaka Kanamori, Takako Yoshioka, Mureo Kasahara, Atsuko Nakazawa, Mayumi Higashi, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Jun Fujishiro, Yoshiakira Kanai. Impact of gallbladder hypoplasia on hilar hepatic ducts in biliary atresia. Communications medicine. 2024.06; 4 (1): 111. ( PubMed, DOI )

  2. Ito M, Ito H, Miyoshi K, Kanai-Azuma M. Chronic non-discriminatory social defeat stress during the perinatal period induces depressive-like outcomes in female mice. Brain Research. 2023.12; 1825 148734. ( PubMed, DOI )

  3. Maruyama N, Fukunaga I, Kogo T, Endo T, Fujii W, Kanai-Azuma M, Naito K, Sugiura K. Accumulation of senescent cells in the stroma of aged mouse ovary. J Reprod Dev. 2023.12; 69 (6): 328-336. ( PubMed, DOI )

  4. Melig G, Nobuhisa I, Saito K, Tsukahara R, Itabashi A, Kanai Y, Kanai-Azuma M, Osawa M, Oshima M, Iwama A, Taga T. A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo. Inflamm Regen. 2023.08; 43 (1): 41. ( PubMed, DOI )

  5. Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, Hirate Y, Akimoto Y, Komada M, Kanai Y, Miyasaka N, Kanai-Azuma M. A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas. J Reprod Dev. 2023.02; 69 (1): 32-40. ( PubMed, DOI )

  6. Aya Uchida, Kenya Imaimatsu, Honoka Suzuki, Xiao Han, Hiroki Ushioda, Mami Uemura, Kasane Imura-Kishi, Ryuji Hiramatsu, Hinako M Takase, Yoshikazu Hirate, Atsuo Ogura, Masami Kanai-Azuma, Akihiko Kudo, Yoshiakira Kanai. SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse. Nat Commun. 2022.12; 13 (1): 7860. ( PubMed, DOI )

  7. Hiroshi Yomogita, Naoyuki Miyasaka, Masami Kanai-Azuma. A Review of Delayed Delivery Models and the Analysis Method in Mice. J Dev Biol. 2022.05; 10 (2): ( PubMed, DOI )

  8. Ryuichi Yamada, Akira Oguri, Katsunori Fujiki, Katsuhiko Shirahige, Yoshikazu Hirate, Masami Kanai-Azuma, Hirotaka Takezoe, Yoshihiro Akimoto, Naoki Takahashi, Yoshiakira Kanai. MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode. Dis Model Mech. 2021.12; 14 (12): ( PubMed, DOI )

  9. Okiko Habara, Catriona Y Logan, Masami Kanai-Azuma, Roeland Nusse, Hinako M Takase. WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility. Development. 2021.05; 148 (9): ( PubMed, DOI )

  10. Yoshikazu Hirate, Kana Hayakawa, Yuki Nakano, Shiori Kumazawa, Kento Miura, Yoshiakira Kanai, Masami Kanai-Azuma. Early Crypt Formation Defects in the Uterine Epithelia of Sox17 Heterozygous Mice. Sex Dev. 2021.03; 14 (1-6): 40-50. ( PubMed, DOI )

  11. Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed, DOI )

  12. Kasane Imura-Kishi, Aya Uchida, Naoki Tsunekawa, Hitomi Suzuki, Hinako M Takase, Yoshikazu Hirate, Masami Kanai-Azuma, Ryuji Hiramatsu, Masamichi Kurohmaru, Yoshiakira Kanai. Low retinoic acid levels mediate regionalization of the Sertoli valve in the terminal segment of mouse seminiferous tubules. Sci Rep. 2021.01; 11 (1): 1110. ( PubMed, DOI )

  13. Montri Pattarapanawan, Mami Uemura, Nanae Miyazaki, Shohei Takami, Hirotaka Tomiyasu, Naoki Tsunekawa, Yoshikazu Hirate, Jun Fujishiro, Masamichi Kurohmaru, Masami Kanai-Azuma, Hiroki Higashiyama, Yoshiakira Kanai. Anatomical and histological characteristics of the hepatobiliary system in adult Sox17 heterozygote mice. Anat Rec (Hoboken). 2020.12; 303 (12): 3096-3107. ( PubMed, DOI )

  14. Takahiko Yamada, Masaki Takechi, Norisuke Yokoyama, Yuichi Hiraoka, Harumi Ishikubo, Takako Usami, Toshiko Furutera, Yuki Taga, Yoshikazu Hirate, Masami Kanai-Azuma, Tetsuya Yoda, Kiyoko Ogawa-Goto, Sachiko Iseki. Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Dev Dyn. 2020.05; 249 (5): 622-635. ( PubMed, DOI )

  15. Mami Uemura, Mayumi Higashi, Montri Pattarapanawan, Shohei Takami, Naoki Ichikawa, Hiroki Higashiyama, Taizo Furukawa, Jun Fujishiro, Yuki Fukumura, Takashi Yao, Tatsuro Tajiri, Masami Kanai-Azuma, Yoshiakira Kanai. Gallbladder wall abnormality in biliary atresia of mouse Sox17 +/- neonates and human infants Dis Model Mech. 2020.04; 13 (4): ( PubMed, DOI )

  16. Rie Saba, Keiko Kitajima, Lucille Rainbow, Silvia Engert, Mami Uemura, Hidekazu Ishida, Ioannis Kokkinopoulos, Yasunori Shintani, Shigeru Miyagawa, Yoshiakira Kanai, Masami Kanai-Azuma, Peter Koopman, Chikara Meno, John Kenny, Heiko Lickert, Yumiko Saga, Ken Suzuki, Yoshiki Sawa, Kenta Yashiro. Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice. Sci Rep. 2019.08; 9 (1): 11953. ( PubMed, DOI )

  17. Risa Nomura, Kenichi Kashimada, Hitomi Suzuki, Liang Zhao, Atsumi Tsuji-Hosokawa, Hideo Yagita, Masatoshi Takagi, Yoshiakira Kanai, Josephine Bowles, Peter Koopman, Masami Kanai-Azuma, Tomohiro Morio. Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling. J. Cell. Sci.. 2019.04; 132 (8): ( PubMed, DOI )

  18. Hirate Y, Hayakawa K, Nakano Y, Uemura M, Miura K, Kanai Y, Kanai-Azuma M. Identification of downstream genes of the uterine SOX17 around the receptive period Experimental Animals. 2018.07; 67 (Suppl.): S67. ( ichushi )

  19. Miura K, Harikae K, Nakaguch M, Imaimatsu K, Hiramatsu R, Tomita A, Hirate Y, Kanai-Azuma M, Kurohmaru M, Ogura A, Kanai Y. Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice. PLoS ONE. 2019; 14 (3): e0212367. ( PubMed, DOI )

  20. Igarashi H, Uemura M, Hiramatsu R, Hiramatsu R, Segami S, Pattarapanawan M, Hirate Y, Yoshimura Y, Hashimoto H, Higashiyama H, Sumitomo H, Kurohmaru M, Saijoh Y, Suemizu H, Kanai-Azuma M, Kanai Y. Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk. Biol. Reprod. 2018.09; 99 (3): 578-589. ( PubMed, DOI )

  21. Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, Taga T. Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis. Exp. Cell Res. 2018.04; 365 (1): 145-155. ( PubMed, DOI )

  22. Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki J. Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018.04; 19 (4): e42054. ( PubMed, DOI )

  23. Higashiyama H, Uemura M, Igarashi H, Kurohmaru M, Kanai-Azuma M and Kanai Y. Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the evolutionary loss of the gallbladder. J. Anat. 2018.01; 232 (1): 134-145. ( PubMed, DOI )

  24. Takase MH, Kanai-Azuma M, Kanai Y. Differentiation of ovaries. Reference Module in Biomedical Sciences. 2018;

  25. Kishi K, Uchida A, Takase HM, Suzuki H, Kurohmaru M, Tsunekawa N, Kanai-Azuma M, Stephen A. Wood and Kanai Y. Spermatogonial deubiquitinase USP9X is essential for proper spermatogenesis in mice. Reproduction. 2017.08; 154 (2): 135-143. ( PubMed, DOI )

  26. Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y. Defects in the first wave of folliculogenesis in mouse XO ovaries. J. Reprod. Dev. 2017.06; 63 (3): 333-338. ( PubMed, DOI )

  27. Ohgaki R, Ohmori T, Hara S,Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y. Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol. Cell. Biol. 2017.06; 37 (11): ( PubMed, DOI )

  28. Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M and Kanai Y. Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017.05; 144 (10): 1906-1917. ( PubMed, DOI )

  29. Uchida A, Kishi K, Aiyama Y, Miura K, Takase HM, Suzuki H, Kanai-Azuma M, Iwamori T, Kurohmaru M, Tsunekawa N, Kanai Y. In vivo dynamics of GFRalpha1-positive spermatogonia stimulated by GDNF signals using a bead transplantation assay. Biochem Biophys Res Commun. 2016.05; ( PubMed, DOI )

  30. Hirate Y, Suzuki H, Kawasumi M, Takase HM, Igarashi H, Naquet P, Kanai Y, Kanai-Azuma M. Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. Sci Rep. 2016.04; 6 24171. ( PubMed, DOI )

  31. Aiyama Y, Tsunekawa N, Kishi K, Kawasumi M, Suzuki H, Kanai-Azuma M, Kurohmaru M, Kanai Y. A Niche for GFRalpha1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes. Stem Cells. 2015.09; 33 (9): 2811-2824. ( PubMed, DOI )

  32. Suzuki H, Kanai-Azuma M, Kanai Y. From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes. Sex Dev. 2015.09; 9 (4): 190-204. ( PubMed, DOI )

  33. Uemura M, Igarashi H, Ozawa A, Tsunekawa N, Kurohmaru M, Kanai-Azuma M, Kanai Y. Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos. J. Vet. Med. Sci. 2015.05; 77 (5): 587-591. ( PubMed, DOI )

  34. Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y. A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads. Reproduction. 2014.12; 148 (6): H1-H9. ( PubMed, DOI )

  35. Takahashi S, Lee J, Kohda T, Matsuzawa A, Kawasumi M, Kanai-Azuma M, Kaneko-Ishino T and Ishino F. Induction of the G2/M transition stabilizes haploid embryonic stem cells. Development. 2014.10; 141 (20): 3842-3847. ( PubMed, DOI )

  36. Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, and Taga T. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014.06; 34 (11): 1976-1990. ( PubMed, DOI )

  37. Mishima T, Fujiwara T, Sanada M, Kofuji T, Kanai-Azuma M, Akagawa K. Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses. PLoS One. 2014.02; 9 (2): e90004. ( PubMed, DOI )

  38. Takada S, Sato T, Ito Y, Yamashita S, Kato T, Kawasumi M, Kanai-Azuma M, Igarashi A, Kato T, Tamano M, Asahara H. Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013.10; 8 (10): e76004. ( PubMed, DOI )

  39. Harikae K, Miura K, Shinomura M, Matoba S, Hiramatsu R, Tsunekawa N, Kanai-Azuma M, Kurohmaru M, Morohashi KI, Kanai Y. Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries. J Cell Sci. 2013.07; 126 (Pt 13): 2834-2844. ( PubMed, DOI )

  40. Uemura M, Ozawa A, Nagata T, Kurasawa K, Tsunekawa N, Nobuhisa I, Taga T, Hara K, Kudo A, Kawakami H, Saijoh Y, Kurohmaru M, Kanai-Azuma M, Kanai Y. Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013.02; 140 (3): 639-648. ( PubMed, DOI )

  41. Sekiuchi M, Kudo A, Nakabayashi K, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamada A. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of matrix metalloproteinases 2 and 1 in the glomeruli of human glomerular diseases: the results of studies using immunofluorescence, in situ hybridization, and immunoelectron microscopy. Clin Exp Nephrol. 2012.12; 16 (6): 863-874. ( PubMed, DOI )

  42. Nagai R, Shinomura M, Kishi K, Aiyama Y, Harikae K, Sato T, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y. Dynamics of GFRalpha1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wnu male mice. Dev Dyn. 2012.08; 241 (8): 1374-1384. ( PubMed, DOI )

  43. Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, and Saijoh Y. Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012.07; 139 (13): 2426-2435. ( PubMed, DOI )

  44. Sato T, Aiyama Y, Ishii-Inagaki M, Hara K, Tsunekawa N, Harikae K, Uemura-Kamata M, Shinomura M, Zhu XB, Maeda S, Kuwahara-Otani S, Kudo A, Kawakami H, Kanai-Azuma M, Fujiwara M, Miyamae Y, Yoshida S, Seki M, Kurohmaru M, Kanai Y. Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes. PLoS ONE. 2011; 6 (12): e28367. ( PubMed, DOI )

  45. Ogawa Y, Miura Y, Harazono A, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamaguchi T, Toda T, Endo T, Tsubuki M, Yanoshita R. Proteomic analysis of two types of exosomes in human whole saliva. Biol. Pharm. Bull. 2011; 34 (1): 13-23. ( PubMed )

  46. Pfister S, Jones VJ, Power M, Truisi GL, Khoo PL, Steiner KA, Kanai-Azuma M, Kanai Y, Tam PP, Loebel DA. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int. J. Dev. Biol. 2011; 55 (1): 45-58. ( PubMed, DOI )

  47. Tashiro F, Kanai-Azuma M, Miyazaki S, Kato M, Tanaka T, Toyoda S, Yamato E, Kawakami H, Miyazaki T, Miyazaki J. Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition. Genes Cells. 2010.08; 15 (8): 813-828. ( PubMed, DOI )

  48. Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, Kurohmaru M, Taya C, Yonekawa H, Kanai-Azuma M, Kanai Y . Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis. Biochem. Biophys. Res. Commun. 2010.01; 391 (1): 357-363. ( PubMed, DOI )

  49. Hara K, Kanai-Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, Kawakami H, Tsunekawa N, Kurohmaru M, Kanai Y. Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis. Dev Biol. 2009.06; 330 (2): 427-439. ( PubMed, DOI )

  50. Ryuji Hiramatsu, Shogo Matoba, Masami Kanai-Azuma, Naoki Tsunekawa, Yuko Katoh-Fukui, Masamichi Kurohmaru, Ken-Ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai. A critical time window of Sry action in gonadal sex determination in mice. Development. 2009.01; 136 (1): 129-138. ( PubMed, DOI )

  51. Shogo Matoba, Ryuji Hiramatsu, Masami Kanai-Azuma, Naoki Tsunekawa, Kyoko Harikae, Hayato Kawakami, Masamichi Kurohmaru, Yoshiakira Kanai. Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation. Dev. Biol. 2008.12; 324 (1): 76-87. ( PubMed, DOI )

  52. Yuko Ogawa, Masami Kanai-Azuma, Yoshihiro Akimoto, Hayato Kawakami, Ryohei Yanoshita. Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Biol. Pharm. Bull. 2008.06; 31 (6): 1059-1062. ( PubMed )

  53. Takuo Mizukami, Yoshiakira Kanai, Masahiko Fujisawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Yoshihiro Hayashi. Five azacytidine, a DNA methyltransferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro. Mol. Reprod. Dev. 2008.06; 75 (6): 1002-1010. ( PubMed, DOI )

  54. Yuko Ogawa, Masami Kanai-Azuma, Yoshihiro Akimoto, Hayato Kawakami, Ryohei Yanoshita. Exosome-like vesicles in Gloydius blomhoffii blomhoffii venom. Toxicon. 2008.05; 51 (6): 984-993. ( PubMed, DOI )

  55. Maryam Kabir-Salmani, Michiko N Fukuda, Masami Kanai-Azuma, Nesar Ahmed, Shigetatsu Shiokawa, Yoshihiro Akimoto, Keiji Sakai, Seishi Nagamori, Yoshikatsu Kanai, Kazuhiro Sugihara, Mitsutoshi Iwashita. The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts. Mol. Endocrinol. 2008.03; 22 (3): 707-715. ( PubMed, DOI )

  56. Masafumi Shimoda, Masami Kanai-Azuma, Kenshiro Hara, Satsuki Miyazaki, Yoshiakira Kanai, Morito Monden, Jun-ichi Miyazaki. Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro. J. Cell. Sci. 2007.11; 120 (Pt 21): 3859-3869. ( PubMed, DOI )

  57. Youhei Sakamoto, Kenshiro Hara, Masami Kanai-Azuma, Toshiyasu Matsui, Yutaroh Miura, Naoki Tsunekawa, Masamichi Kurohmaru, Yukio Saijoh, Peter Koopman, Yoshiakira Kanai. Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem. Biophys. Res. Commun. 2007.08; 360 (3): 539-544. ( PubMed, DOI )

  58. Mayuko Ishii, Tsuyoshi Tachiwana, Anshin Hoshino, Naoki Tsunekawa, Ryuji Hiramatsu, Shogo Matoba, Masami Kanai-Azuma, Hayato Kawakami, Masamichi Kurohmaru, Yoshiakira Kanai. Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice. Development. 2007.02; 134 (3): 449-454. ( PubMed, DOI )

  59. Jiho Sohn, JoAnne Natale, Li-Jin Chew, Shibeshih Belachew, Ying Cheng, Adan Aguirre, Judith Lytle, Brahim Nait-Oumesmar, Christophe Kerninon, Masami Kanai-Azuma, Yoshiakira Kanai, Vittorio Gallo. Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J. Neurosci. 2006.09; 26 (38): 9722-9735. ( PubMed, DOI )

  60. Toshiyasu Matsui, Masami Kanai-Azuma, Kenshiro Hara, Shogo Matoba, Ryuji Hiramatsu, Hayato Kawakami, Masamichi Kurohmaru, Peter Koopman, Yoshiakira Kanai. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J. Cell. Sci. 2006.09; 119 (Pt 17): 3513-3526. ( PubMed, DOI )

  61. Maki Ishii, Yoshiakira Kanai, Masami Kanai-Azuma, Youichi Tajima, Tay Tat Wei, Tomohide Kidokoro, Yutaka Sanai, Masamichi Kurohmaru, Yoshihiro Hayashi. Adhesion activity of fetal gonadal cells to EGF and discoidin domains of milk fat globule-EGF factor 8 (MFG-E8), a secreted integrin-binding protein which is transiently expressed in mouse early gonadogenesis. Anat. Embryol. 2005.07; 209 (6): 485-494. ( PubMed, DOI )

  62. Shogo Matoba, Yoshiakira Kanai, Tomohide Kidokoro, Masami Kanai-Azuma, Hayato Kawakami, Yoshihiro Hayashi, Masamichi Kurohmaru. A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation. J. Cell. Sci. 2005.04; 118 (Pt 7): 1449-1459. ( PubMed, DOI )

  63. Tomohide Kidokoro, Shogo Matoba, Ryuji Hiramatsu, Masahiko Fujisawa, Masami Kanai-Azuma, Choji Taya, Masamichi Kurohmaru, Hayato Kawakami, Yoshihiro Hayashi, Yoshiakira Kanai, Hiromichi Yonekawa. Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev. Biol. 2005.02; 278 (2): 511-525. ( PubMed, DOI )

  64. Takeshi Sato, Yoshiakira Kanai, Takashi Noma, Masami Kanai-Azuma, Shinichiro Taya, Toshiyasu Matsui, Maki Ishii, Hayato Kawakami, Masamichi Kurohmaru, Kozo Kaibuchi, Stephen A Wood, Yoshihiro Hayashi. A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Reproduction. 2004.11; 128 (5): 583-594. ( PubMed, DOI )

  65. Toshimitsu Fuse, Yoshiakira Kanai, Masami Kanai-Azuma, Misao Suzuki, Kazuhiro Nakamura, Hisashi Mori, Yoshihiro Hayashi, Masayoshi Mishina. Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation. Biochem. Biophys. Res. Commun. 2004.06; 318 (3): 665-672. ( PubMed, DOI )

  66. Hiramatsu R, Kanai Y, Mizukami T, Ishii M, Matoba S, Kanai-Azuma M, Kurohmaru M, Kawakami H, Hayashi Y. Regionally distinct potencies of mouse XY genital ridge to initiate testis differentiation dependent on anteroposterior axis. Dev Dyn. 2003.10; 228 (2): 247-253. ( PubMed, DOI )

  67. Masaharu Kotani, Youichi Tajima, Taka Osanai, Atsushi Irie, Ken Iwatsuki, Masami Kanai-Azuma, Masato Imada, Hiroko Kato, Hiroshi Shitara, Hideo Kubo, Hitoshi Sakuraba. Complementary DNA cloning and characterization of RANDAM-2, a type I membrane molecule specifically expressed on glutamatergic neuronal cells in the mouse cerebrum. J. Neurosci. Res. 2003.09; 73 (5): 603-613. ( PubMed, DOI )

  68. Patrick P L Tam, Masami Kanai-Azuma, Yoshiakira Kanai. Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr. Opin. Genet. Dev. 2003.08; 13 (4): 393-400. ( PubMed )

  69. Kuniko Nakano, Masami Kanai-Azuma, Yoshiakira Kanai, Kenji Moriyama, Kazumori Yazaki, Yoshihiro Hayashi, Naomi Kitamura. Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. Exp. Cell Res. 2003.07; 287 (2): 219-227. ( PubMed )

  70. Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A Wood, Yoshihiro Hayashi. Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice. Mech. Dev. 2002.12; 119 Suppl 1 S91-S95. ( PubMed )

  71. Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A Wood, Yoshihiro Hayashi. Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice. Gene Expr. Patterns. 2002.11; 2 (1-2): 87-91. ( PubMed )

  72. Masami Kanai-Azuma, Yoshiakira Kanai, Jacqueline M Gad, Youichi Tajima, Choji Taya, Masamichi Kurohmaru, Yutaka Sanai, Hiromichi Yonekawa, Kazumori Yazaki, Patrick P L Tam, Yoshihiro Hayashi. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002.05; 129 (10): 2367-2379. ( PubMed )

  73. Pantaleon M, Kanai-Azuma M, Mattick JS, Kaibuchi K, Kaye PL, Wood SA. FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev. 2001.12; 109 (2): 151-160. ( PubMed )

  74. Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC. Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci. 2001.03; 13 (5): 935-948. ( PubMed )

  75. Kanai Y, Kanai-Azuma M, Tajima Y, Birk OS, Hayashi Y, Sanai Y. Identification of a stromal cell type characterized by the secretion of a soluble integrin-binding protein, MFG-E8, in mouse early gonadogenesis. Mech Dev. 2000.09; 96 (2): 223-227. ( PubMed )

  76. Kanai-Azuma M, Mattick JS, Kaibuchi K, Wood SA. Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development. Mech Dev. 2000.03; 91 (1-2): 383-386. ( PubMed )

  77. Kanai-Azuma M, Kanai Y, Okamoto M, Hayashi Y, Yonekawa H, Yazaki K. Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999.12; 89 (1-2): 155-159. ( PubMed )

  78. Taya S, Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K. The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes Cells. 1999.12; 4 (12): 757-767. ( PubMed )

  79. Taya S, Yamamoto T, Kano K, Kawano Y, Iwamatsu A, Tsuchiya T, Tanaka K, Kanai-Azuma M, Wood SA, Mattick JS, Kaibuchi K. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J Cell Biol. 1998.08; 142 (4): 1053-1062. ( PubMed )

  80. Kanai-Azuma M, Kanai Y, Matsuda H, Kurohmaru M, Tachi C, Yazaki K, Hayashi Y. Nerve growth factor promotes giant-cell transformation of mouse trophoblast cells in vitro. Biochem Biophys Res Commun. 1997.02; 231 (2): 309-315. ( PubMed, DOI )

  81. Tanemura K, Kanai Y, Kanai-Azuma M, Kurohmaru M, Kuramoto K, Yazaki K, Hayashi Y. Reinitiation of spermatogonial mitotic differentiation in inactive old BDF1 mouse seminiferous tubules transplanted to W/Wv mouse testis. Biol Reprod. 1996.12; 55 (6): 1237-1242. ( PubMed )

  82. Kanai Y, Kanai-Azuma M, Noce T, Saido TC, Shiroishi T, Hayashi Y, Yazaki K. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996.05; 133 (3): 667-681. ( PubMed )

  83. Kanai Y, Kanai-Azuma M, Kurohmaru M, Yazaki K, Hayashi Y. Effects of extracellular matrix on differentiation of mouse fetal gonads in the absence of mesonephros in vitro. Microsc Res Tech. 1995.12; 32 (5): 437-448. ( PubMed, DOI )

  84. Kanai-Azuma M, Kanai Y, Kurohmaru M, Sakai S, Hayashi Y. Insulin-like growth factor (IGF)-I stimulates proliferation and migration of mouse ectoplacental cone cells, while IGF-II transforms them into trophoblastic giant cells in vitro. Biol Reprod. 1993.02; 48 (2): 252-261. ( PubMed )

  85. Kanai Y, Kawakami H, Kanai-Azuma M, Kurohmaru M, Hirano H, Hayashi Y. Changes in intracellular and cell surface localization of Le(x) epitope during germ cell differentiation in fetal mice. J Vet Med Sci. 1992.04; 54 (2): 297-303. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. 韓 笑, 中村 幸祐, 内田 あや, 李 瑞賢, 柳田 絢加, 平松 竜司, 金井 正美, 金井 克晃. Sox17強制発現によるセルトリバルブの過形成とSox17陽性精巣網との機能相補. 第117回日本繁殖生物学会 2024.09.23 名古屋大学野依記念学術交流館・シンポジオンホール

  2. Melig Gerel, Nobuhisa Ikuo, Saito Kioka,Tsukahara Ryota, Itabashi Ayumi, Kanai Yoshiakira, Kanai-Azuma Masami, Taga Tetsuya. Rasip1 is a downstream effector of Sox17 that plays a role in maintaining hematopoietic cluster cells in midgestation mouse embryos. 第45回日本炎症・再生医学会 2024.07.17 福岡国際会議場

  3. 水野直彬, 長野寿人, 佐藤秀征, 水谷英二, 柳田絢加, 加納麻弓子, 笠井真理子, 山本祐美, 渡部素生, サッチーファビアン, 正木英樹, 金井正美,中内啓光. 細胞競合と胎仔発生環境を用いた完全な移植用皮膚片の作成. 第71回日本実験動物学会総会 2024.05.29 みやこめっせ・ロームシアター京都

  4. MELIG Gerel, NOBUHISA Ikuo, NOBUHISA Ikuo, SAITO Kiyoka, TSUKAHARA Ryota, ITABASHI Ayumi, KANAI Yoshiakira, KANAI-AZUMA Masami, TAGA Tetsuya. Rasip1 is a novel Sox17 downstream target gene and cooperating factor for the maintenance of the hematopoietic cluster cells in E10.5 midgestation mouse embryo. 第46回日本分子生物学会年会 2023.12 神戸ポートアイランド

  5. Takami S, Uemura M, Miyazaki N, Oiki H, Yoshioka T, Nakazawa A, Higashi M, Kanai-Azuma M, Kanai Y, Fujishiro J. Gallbladder wall with reduced Sox17 expression in biliary atresia:gallbladder-dependent hepatic damage and its better prognosis.. The Pacific Association of Pediatric Surgeons 56th Annual Meeting 2023.09.10 The Westin Hotel Nusa Dua BaliまたはOnline

  6. Ito H, Ito M, Miyoshi K, Kanai-Azuma M. Development of a novel depression model in female mice.. The46th Annual Meeting of the Japan Neuroscience Society 2023.08.01 Sendai International Center

  7. Gerel Melig,ikuo Nobuhisa,Kiyoka Saito,Ryota Tsukahara,Ayumi Itabashi,Yoshiakira Kanai,Masami Kanai-Azuma,Tetsuya Taga. Rasip1 helps maintenance of hematopoietic activities of mouse embryonic intra-aortic hematopoietic clusters.. The 44th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2023.07.12 City Plaza Osaka

  8. Gerel Melig,ikuo Nobuhisa,Kiyoka Saito,Ryota Tsukahara,Ayumi Itabashi,Yoshiakira Kanai,Masami Kanai-Azuma,Tetsuya Taga. Rasip1 gene functioning downstream of Sox17 maintains the hematopoietic cluster-forming cella in E10.5 mouse embryos.. 20th Stem Cell Symposium 2023.05.19 Awaji Yumebutai International Conference Center

  9. Gerel Melig,Ikuo Nobuhisa,Kiyoka Saito,Ryota Tsukahara,Ayumi Itabashi,Yoshiakira Kanai,Masami Kanai-Azuma,Tetsuya Taga . Rasip is involved in the positive regulation of hematopoietic activity in E10.5 intra-aortic hematopoietic cluster cells. The 45th Annual Meeting of the Molecular Biology Society of Japan 2022.11.30 Makuhari Messe

  10. Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Investigating the function of Rasip1 in HSC-containing IAHCs of midgestation mouse embryos. 19th Stem Cell Symposium 2022.05.27 Awaji Yumebutai International Conference Center

  11. 山田竜一、小栗晶、藤木克則、白髭克彦、平手良和、金井正美、竹添裕高、金井克晃、高橋直樹. Mab21l1欠損マウスレンズ前駆細胞の1細胞解析. 第43回日本分子生物学会 2020.12.02 Web開催

  12. Gerel Melig,Ikuo Nobuhisa,Saito Kiyoka,Ryota Tsukahara,Ayumi Itabashi,Yoshiakira Kanai,Masami Kanai,Tetsuya Taga. Contribution of Rasip1 to the maintenance of hematopoietic activity of cluster-forming cells in midgestation mouse embryos. 第43回日本分子生物学会 2020.12.02 Web開催

  13. Gerel Melig,Ikuo Nobuhisa,Saito Kiyoka,Ryota Tsukahara,Ayumi Itabashi,Yoshiakira Kanai,Masami Kanai,Tetsuya Taga. Role of the Rasip1 in the hematopoiesis of HSC-containing hematopoietic cluster cell in midgestation of mouse embryos. 第41回日本炎症・再生医療学会 2020.07.08 Web開催

  14. Involvement of transcription factor Sox17-mediated GIMAP6 expression in the hematopoietic capacity in midgestation mouse dorsal aorta. 第18回幹細胞シンポジウム 2020.06.05 Web開催

  15. Fujioka Yoshifumi, Ishii Masayuki, Shiura Hirosuke, Ono Ryuuichi, Kanai Masami, Kaneko-Ishino Tomoko, Ishino Fumitoshi. 哺乳類特異的レトロトランスポゾン由来遺伝子Sirh4、5、6の機能解析(Functional analysis of mammalian-specific retrotransposon-derived genes Sirh4, 5, 6). Experimental Animals 2021.06.01

  16. Rie Saba,Keiko Kitajima,Yasunori Shintani,Yoshiakira Kanai,Masami Kanai-Azuma,Chikara Meno,Yumiko Saga,Ken Suzuki,Shigeru Miyagawa,Yoshiki Sawa,Hideya Yamazaki,Kei Yamada,Kenta Yashiro. SOX17 expression in the endocardium precursor cells regulates the mouse heart development.. 第42回日本分子生物学会年会 2019.12.03 福岡県福岡市

  17. Masami Kanai. Defects in the early crypt formation of the uterine epithelia in Sox17 heterozygous mice. SOX meeting 2019 : Vth International SOX Research Conference 2019.10.01 Marseille,FRANCE

  18. Masami Kanai-Azuma. Mouse model of human female infertility. 第8回日本・中国・韓国マウスリソースワークショップ 2019.08.26 つくば（理化学研究所バイオリソース研究センター内）

  19. Yoshikazu Hirate,Hitomi Takahashi,Yoshiaki ito,Jilnling Li,Chiho Ohtsuka,Hiroshi Asahara,Ruby Yanru Chen-tsai,Masami Kanai-Azuma. Site-diected transgenic mice production using TARGATTtmKnock-in technology in TMDU. 15th TRANSGENIC TECHNOLOGY MEETING 2019.04.07 神戸国際会議場

  20. Pattarapanawan Montri, 上村 麻美, 東山 大毅, 平松 竜司, 恒川 直樹, 九郎丸 正道, 金井 正美, 金井 克晃. 胆道閉鎖症マウスモデルにおける成体Sox17+/-肝胆系の表現型(Phenotypes of Adult Sox17+/- Hepatobiliary System in a Mouse Model of Biliary Atresia). 日本獣医学会学術集会講演要旨集 2018.08.01

  21. Hirate Y, Kanai Y, Kanai-Azuma M. Molecular pathways downstream of Sox17 in uterine epithelia during mouse implantation processes. Eighth International Symposium on Vertebrate Sex Determination 2018.04.16 Kona, Hawaii

  22. Kashimada K, Nomura R, Suzuki H, Liang Z, Tsuji-Hosokawa A, Kanai Y, Yagita H, Josephine B, Peter K, Kanai-Azuma M, Morio T. Enforced expression of NA5A1 in mouse fetal ovaries causes premature ovarian insufficiency by dysregulating notch signalling. Eighth International Symposium on Vertebrate Sex Determination 2018.04.16 Kona, Hawaii

  23. Nomura R, Suzuki H, Liang Z, Hosokawa-Tsuji A, Kanai Y, Yagita H, Josephine B, Peter K, Morio T, Kanai-Azuma M, Kashimada K. The suppression of NR5A1/Ad4BP/SF1 during fetal period is essential for optimizing the ovarian development through Notch signaling in mice. The 100th Endocrine Society Annual Meeting and Expo 2018.03.17 Chicago

  24. Pattarapanawan M, Uemura M, Higashiyama H, Hiramatsu R, Tsunekawa N, Kurohmaru M, Kanai-Azuma M, Kanai Y. Phenotypes of Adult Sox17+/- Hepatobiliary System in a Mouse Model of Biliary Atresia. The joint Symposium of the 9th Veterinary Research among Universities of Veterinary Medicine in East Asia 2018.02.22 Korea

  25. Pattarapanawan　M,　Uemura M, Higashiyama H, Hiramatsu R, Tsunekawa N, Kurohmaru M, Kanai-Azuma M, Kanai Y.. Morphological change in hepatobiliary and related structures in postnatal and adult Sox17+/- mice. 6th congress-asian-veterinary-anatomists 2017.10.15 Malaysia

  26. Hirate Yoshikazu, Hayakawa Kana, Toyomura Yuga, Igarashi Hitomi, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami. Sox17heterozygous mutant females are defective in implantation. Annual Meeting of the Japanese Society of Developmental Biologists 50th 2017.05.10 Tower Hall Funabori

  27. Kanai-Azuma Masami, Yoshikazu Hirate, Miyuri Kawasumi, Hitomi Suzuki, Yoshiakira Kanai. A possible involvement of a dose-dependent Sox17 activity of uterine epithelia in mouse implantation processes. 7th International Symposium Biology of Vertebrate Sex Determination 2015.04.13 Kona, Hawaii

  28. Kento Miura,Masami Kanai-Azuma,Yoshiakira Kanai. Common molecular pathways between SRY-dependent and –independent testiculogenesis in mouse fetal gonads. 4th International SOX Research Conference 2014.09.08 Cleveland,Ohio,USA

  29. Masami Kanai-Azum. Sox17 haploinsufficiency causes maternal defects in implantation,leading to reduced female fertility. 4th International SOX Research Conference 2014.09.08 Cleveland,Ohio,USA

  30. Masami Kanai-Azuma, Yoshimi Aiyama,Miyuri Kawasumi,Yoshiakira Kanai. LUMINAL FLUID FLOW SUPPORTS CONTINOUS SPERMATOGENESIS THROUGH THE BALANCED GDNF REGULATION. Gordon Research conference on germinal Stem Cell Biology 2013.07.14 Hongkong

  31. Kenta Yashiro, Ioannis kokkinopoulos, Rie Saba, Hidekazu Ishida, Yumiko Saga, Masami Kanai-Azuma, Keiko Kitajima, Chikara Meno, Yoshiakira Kanai, Peter Koopman, Hiroshi Hamada & Ken Suzuki, Tetsuya Taga. Single-Cell cDNA Analyses of embryonic cardiac progenitor cells. 17th International Congress of Developmental Biology 2013.06.16 Cancun Mexico

  32. Ikuo Nobuhisa, Mitsujiro Osawa, Mami Uemura, Yoko Kishikawa, Maha Anani, Kaho Harada, Haruna Takagi, Masami Kanai-Azuma, Yoshiakira Kanai, Atsushi Iwama, Tetsuya Taga. Sox17 protein-mediated maintenance of cells with stem cell phenotype in the hematopoietic cell clusters in the fetal AGM region. The 11th Stem Cell Research Symposium 2013.05.17 Tokyo Univ.

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