Personnel Information

写真a

NAKASHIMA Tomoki


Job title

Professor

Mail Address

naka.csi@tmd.ac.jp

Campus Career 【 display / non-display

  • 2007.04
    -
    2013.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Assistant Professor
  • 2013.04
    -
    2016.02
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Associate Professor
  • 2016.03
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Professor
  • 2018.04
    -
    2020.06
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Professor
  • 2020.07
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Professor

External Career 【 display / non-display

  • 2001.04
    -
    2002.04
    , Project Researcher

Academic Activity 【 display / non-display

  • 2017.08
    -
    Now
    Bone Research Board member

Research Areas 【 display / non-display

  • Molecular biology

  • Metabolomics

  • Pathological medical chemistry

  • General medical chemistry

  • Functional basic dentistry

Qualification Acquired 【 display / non-display

  • Pharmacist

 

Research Theme 【 display / non-display

  • Regulation mechanism of bone remodeling

Published Papers & Misc 【 display / non-display

  • Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi. Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A. 2021.08; 118 (35): ( PubMed, DOI )

  • Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-Yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M Girisha, Shiro Ikegawa. Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling. Nat Commun. 2021.04; 12 (1): 2046. ( PubMed, DOI )

  • Noriko Komatsu, Stephanie Win, Minglu Yan, Nam Cong-Nhat Huynh, Shinichiro Sawa, Masayuki Tsukasaki, Asuka Terashima, Warunee Pluemsakunthai, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi. Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. J Clin Invest. 2021.03; 131 (6): ( PubMed, DOI )

  • Fumiyuki Sasaki, Mikihito Hayashi, Takehito Ono, Tomoki Nakashima. The regulation of RANKL by mechanical force. J Bone Miner Metab. 2021.01; 39 (1): 34-44. ( PubMed, DOI )

  • Nasir K Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, Hiroaki Suga. Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation. Proc Natl Acad Sci U S A. 2020.12; 117 (49): 31070-31077. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • 小野岳人、傳田良亮、権藤理夢、河崎万鈴、木下佑理、中島友紀. ケミカルライブラリーを用いた新規スクリーニング法による運動器疾患の治療薬探索. 第4回日本骨免疫学会 2018.06.24 沖縄

  • Tomoki Nakashima. Bone homeostasis and mechanomedicine. 第95回 日本生理学会 2018.03.29 高松

  • Tomoki Nakashima. Bone homeostasis and mechano-biology. The 94th Annual Meeting of the Physiological Society of Japan 2017.03.28 Hamamatsu

  • Tomoki Nakashima . Regulation of bone remodeling . 3nd Seoul Symposium on Bone Health KSBMR-JSBMR joint symposium 2015.05.27 Seoul

  • M. Hayashi, T. Nakashima, and H. Takayanagi. Regulation of bone metabolism by Semaphorin 3A derived from osteoblastlineage cells.. ASBMR 2014 Annual Meeting 2014.09.13

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Awards & Honors 【 display / non-display

  • U.S. National Academy of Medicine Catalyst Award,U.S. National Academy of Medicine (NAM),2020.10

  • IADR/AADR William J. Gies Award,International Association for Dental Research,2018.08