Personnel Information

写真a

FUNATO Noriko


Job title

Associate Professor

Laboratory Address

Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JAPAN

Mail Address

noriko-funato@umin.ac.jp

Homepage URL

http://www.tmd.ac.jp/cmn/gene/indexe.htm

Research Areas, Keywords

bone, palate, development, protein-protein interaction, transcription factor
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Dentistry, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Doctor's Course, Completed

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Campus Career 【 display / non-display 】

  • 2009.04
    -
    2014.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Signal Gene Regulation， Junior Associate Professor
  • 2014.04
    -
    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Research Center for Medical and Dental Sciences， Associate Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Signal Gene Regulation， Associate Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Center for Medical and Dental Sciences， Associate Professor
  • 2017.05
    -
    2017.07
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Center for Medical and Dental Sciences， Research Core， Associate Professor
  • 2017.08
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Center for Medical and Dental Sciences， Research Core， Associate Professor
  • 2020.10
    -
    2024.04
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Research Core， Associate Professor
  • 2024.05
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Oral Science Center， Associate Professor

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External Career 【 display / non-display 】

  • UT Southwestern Medical Center, Department of Molecular Biology, Project Junior Associate Professor
  • Japan Society for the Promotion of Science, Postdoctral Fellowship for Research Abroad
  • Japan Society for the Promotion of Science, Research Fellowship for Young Scientists
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Academic Society Affiliations 【 display / non-display 】

  • American Society of Human Genetics

  • The International Association for Dental Research

  • The Japanese Association for Dental Research (JADR)

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Research Areas 【 display / non-display 】

  • Oral biological science

  • Oral pathobiological science

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Qualification Acquired 【 display / non-display 】

  • Dentist

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Published Papers & Misc 【 display / non-display 】

  1. Noriko Funato, Arja Heliövaara, Cedric Boeckx. A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens. Am J Hum Genet. 2024.05; 111 (5): 939-953. ( PubMed, DOI )

  2. Noriko Funato*, Hiromi Yanagisawa. TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties. Scientific Reports. 2022.11; 12 (1): 20188. ( PubMed, DOI )

  3. Yuki Taga, Yu Iwasaki, Chisa Tometsuka, Noriko Funato, Yasutaka Shigemura, Masashi Kusubata, Kazunori Mizuno. Identification of a highly stable bioactive 3-hydroxyproline-containing tripeptide in human blood after collagen hydrolysate ingestion. NPJ Sci Food. 2022.06; 6 (1): 29. ( PubMed, DOI )

  4. Noriko Funato*. Craniofacial Phenotypes and Genetics of DiGeorge Syndrome. Journal Developmental Biology. 2022.05; 10 (2): 18. ( PubMed, DOI )

  5. Tometsuka C, Funato N, Mizuno K, Taga Y. Long-term intake of ginger protease-degraded collagen hydrolysate reduces blood lipid levels and adipocyte size in mice. Current research in food science. 2021.03; 4 175-181. ( PubMed, DOI )

  6. Noriko Funato*, Yuki Taga, Lindsay E Laurie, Chisa Tometsuka, Masashi Kusubata, Kiyoko Ogawa-Goto. The Transcription Factor HAND1 Is Involved in Cortical Bone Mass through the Regulation of Collagen Expression. Int J Mol Sci. 2020.11; 21 (22): 8638. ( PubMed, DOI )

  7. N Funato*, D Srivastava, S Shibata, H Yanagisawa. TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis. Journal of Dental Research. 2020.09; 99 (10): 1182-1191. ( PubMed, DOI )

  8. Funato N*. New Insights into Cranial Synchondrosis Development: A Mini Review. Frontiers in Cell and Developmental Biology. 2020.08; 8 (706): 1-9. ( PubMed, DOI )

  9. *Noriko Funato, Hiromi Yanagisawa. Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Archives of Oral Biology. 2018.08; 95 149-155. ( PubMed, DOI )

  10. Yuki Taga, Masashi Kusubata, Kiyoko Ogawa-Goto, Shunji Hattori, and Noriko Funato. Collagen-derived X-Hyp-Gly-type tripeptides promote differentiation of MC3T3-E1 pre-osteoblasts Journal of Functional Foods. 2018.07; 46 456-462. ( DOI )

  11. Identification of Collagen-Derived Hydroxyproline (Hyp)-Containing Cyclic Dipeptides with High Oral Bioavailability: Efficient Formation of Cyclo(X-Hyp) from X-Hyp-Gly-Type Tripeptides by Heating 2017.11; ( DOI )

  12. *Noriko Funato, Masataka Nakamura. Identification of shared and unique gene families associated with oral clefts. Int J Oral Sci. 2017.06; 9 (2): 104-109. ( PubMed, DOI )

  13. *Noriko Funato, Hiroki Kokubo, Yumiko Saga. Transcriptomic analyses of Hand2 transgenic embryos. Genom Data. 2016.06; 9 60-62. ( PubMed, DOI )

  14. *Noriko Funato, Hiroki Kokubo, Masataka Nakamura, Hiromi Yanagisawa, Yumiko Saga. Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016.06; 6 28405. ( PubMed, DOI )

  15. Lindsay E Laurie, Hiroki Kokubo, Masataka Nakamura, Yumiko Saga, *Noriko Funato. The transcription factor Hand1 is involved in Runx2-Ihh-regulated endochondral ossification PLoS ONE. 2016.02; 11 (2): e0150263. ( PubMed, DOI )

  16. Mariko Mizuguchi, Yuka Sasaki, Toshifumi Hara, Masaya Higuchi, Yuetsu Tanaka, Noriko Funato, Nobuyuki Tanaka, Masahiro Fujii, Masataka Nakamura. Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax. PLoS ONE. 2016.02; 11 (2): e0148217. ( PubMed, DOI )

  17. Noriko Funato, Masataka Nakamura, Hiromi Yanagisawa. Molecular basis of cleft palates in mice. World J Biol Chem. 2015.08; 6 (3): 121-138. ( PubMed, DOI )

  18. Noriko Funato, Masataka Nakamura, James A. Richardson, Deepack Srivastava, Hiromi Yanagisawa.. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet. 2015.01; 24 (2): 424-435. ( PubMed, DOI )

  19. Jumpei Morita, Masataka Nakamura, Yukiho Kobayashi, Chu-Xia Deng, Noriko Funato, Keiji Moriyama. Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model. Dev. Dyn.. 2014.04; 243 (4): 560-567. ( PubMed, DOI )

  20. Terumi Mizukoshi, Hideyuki Komori, Mariko Mizuguchi, Hussein Abdelaziz, Toshifumi Hara, Masaya Higuchi, Yuetsu Tanaka, Yoshiro Ohara, Noriko Funato, Masahiro Fujii, Masataka Nakamura. Failure in activation of the canonical NF-κB pathway by human T-cell leukemia virus type 1 Tax in non-hematopoietic cell lines. Virology. 2013.09; 443 (2): 226-235. ( PubMed, DOI )

  21. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012.03; 21 (11): 2524-2537. ( PubMed, DOI )

  22. Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H. Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development. 2009.02; 136 (4): 615-625. ( PubMed, DOI )

  23. Barbosa AC, Funato N, Chapman S, McKee MD, Richardson JA, Olson EN, Yanagisawa H. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol. 2007.10; 310 (1): 154-168. ( PubMed, DOI )

  24. Ohkuma M, Funato N, Higashihori N, Murakami M, Ohyama K, Nakamura M. Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines. Biochem Biophys Res Commun. 2007.01; 352 (4): 925-931. ( PubMed, DOI )

  25. Funato N, Twigg SR, Higashihori N, Ohyama K, Wall SA, Wilkie AO, Nakamura M. Functional analysis of natural mutations in two TWIST protein motifs. Hum Mutat. 2005.06; 25 (6): 550-556. ( PubMed, DOI )

  26. Funato N, Nohtomi-Ohyama J, Ohyama K. Monozygotic twins concordant for Crouzon syndrome. Am J Med Genet A. 2005.03; 133A (2): 225. ( PubMed, DOI )

  27. Takahashi E, Funato N, Higashihori N, Hata Y, Gridley T, Nakamura M. Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist. Biochem Biophys Res Commun. 2004.12; 325 (4): 1136-1144. ( PubMed, DOI )

  28. Kanda T, Funato N, Baba Y, Kuroda T. Evidence for fibroblast growth factor receptors in myofibroblasts during palatal mucoperiosteal repair. Arch Oral Biol. 2003.03; 48 (3): 213-221. ( PubMed )

  29. Funato N, Ohyama K, Kuroda T, Nakamura M. Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. J Biol Chem. 2003.02; 278 (9): 7486-7493. ( PubMed, DOI )

  30. Funato N, Ohtani K, Ohyama K, Kuroda T, Nakamura M. Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. Mol Cell Biol. 2001.11; 21 (21): 7416-7428. ( PubMed, DOI )

  31. Hatai T, Yokozeki M, Funato N, Baba Y, Moriyama K, Ichijo H, Kuroda T. Apoptosis of periodontal ligament cells induced by mechanical stress during tooth movement. Oral Dis. 2001.09; 7 (5): 287-290. ( PubMed )

  32. Funato N, Moriyama K, Baba Y, Kuroda T. Evidence for apoptosis induction in myofibroblasts during palatal mucoperiosteal repair. J Dent Res. 1999.09; 78 (9): 1511-1517. ( PubMed )

  33. Funato N, Moriyama K, Saitoh M, Baba Y, Ichijo H, Kuroda T. Evidence for apoptosis signal-regulating kinase 1 in the regenerating palatal epithelium upon acute injury. Lab Invest. 1998.04; 78 (4): 477-483. ( PubMed )

  34. Funato N, Moriyama K, Shimokawa H, Kuroda T. Basic fibroblast growth factor induces apoptosis in myofibroblastic cells isolated from rat palatal mucosa. Biochem Biophys Res Commun. 1997.11; 240 (1): 21-26. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  1. Kevin V. Urbano (Editor), Noriko Funato et al.,. Advances in Genetics Research. Vol 21. Nova Science Publishers, Inc.， 2022.02 Genetic Factors Associated with Cleft Lip and/or Palate (ISBN : 978-1-68507-562-0)

  2. Kuroda T, Ohyama K, Motohashi N, Moriyama K Eds／Funato N et al.. Atlas of Orthodontic Treatment for Patients with Birth Defects. Needham Press， 2012

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Conference Activities & Talks 【 display / non-display 】

  1. 船戸 紀子. DiGeorge症候群疾患遺伝子TBX1は口蓋形成においてmiR-200–ZEB2軸を標的にする. 第65回歯科基礎医学会学術大会 2023.09.17 東京

  2. Noriko Funato, Hiromi Yanagisawa. TBX1 associated with DiGeorge syndrome targets the miR-200–ZEB2 axis. Gordon Research Conference (Human Genetics and Genomics) 2023.07.11 Waterville Valley, NH, United States

  3. Funato N, Srivastava D, Shibata S, Yanagisawa H. TBX1 suppresses transcriptional activity of RUNX2 and regulates chondrocyte maturation. Cell Bio Virtual 2020-An Online ASCB|EMBO Meeting 2020.12.01 Online

  4. Noriko Funato, Yuki Taga, Lindsay E. Laurie, Chisa Tometsuka, Masashi Kusubata, Kiyoko Ogawa-Goto.. The bHLH transcription factor HAND1 is involved in cortical bone volume through the regulation of collagen expression.. the 68th Annual Meeting of Japanese Association for Dental Research 2020.11.07 Online

  5. Funato N, Srivastava D, Shibata S, Yanagisawa H.. TBX1 regulates chondrocyte maturation in the spheno-occipital synchondrosis through TBX1-RUNX2 axis. the 62nd Annual Meeting of Japanese Association for Oral Biology 2020.09.12 Online

  6. Noriko Funato. Craniofacial Development: Using Computational Data for Generating Experimental Data. Frontier Meeting 2019.02.15 Tokyo Medical and Dental University, Tokyo, Japan

  7. Funato N, Srivastava D, Yanagisawa H. Tbx1 knockout mice exhibit dysregulated expression of genes associated with cleft palate in humans. ASCB/EMBO 2017 Meeting 2017.12.05 Philadelphia, USA

  8. Taga Y, Laurie LE, Kokubo H, Saga Y, Kusubata M, Ogawa-Goto K, Hattori S, Funato N. Role of HAND1 in collagen expression and post-translational modifications in the long bone. ASCB/EMBO 2017 Meeting 2017.12.05 Philadelphia, USA

  9. Taga Y, Kusubata M, Ogawa-Goto K, Hattori S, Funato N. Gelatin Hydrolysates Prepared Using Ginger Protease Promote Osteoblast Differentiation. The 65th Annual Meeting of Japanese Association for Dental Research 2017.11.18 Showa University, Tokyo

  10. Funato N, Yanagisawa H, Nakamura M. Gene Ontology Analysis for Cleft Palate. 2015 ASCB（The American Society for Cell Biology） Annual Meeting 2015.12.15

  11. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Japanese Division of the International Association for Dental Research (JADR). 2014.12.05

  12. Preston LE, Kokubo H, Nakamura M, Saga Y, Funato N. Hand1 regulates endochondral ossification. IADR (International Association for Dental Research) 2014.06.27

  13. Funato N, Nakamura M. Protein inhibitors of activated STAT (PIAS) proteins are new negative regulators of Runx2. Annual Meeting of the American Society for Cell Biology in San Francisco 2012.12.16

  14. Morita J, Funato N, Kobayashi Y, Nakamura M, and Moriyama K. Soluble FGFR2 with S252W prevent craniosynostosis of Apert model mouse.. Japanese Association of Dental Research 2012.12.12

  15. Funato N, Nakamura M.. Protein Inhibitors of Activated STAT (PIAS) Proteins Regulate Runx2 Transactivation Activity.. ASBMR 2011 Annual Meeting 2011.09.19

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Others 【 display / non-display 】

  • ScienceDaily，2024.04

    Genetic variant identified that shaped the human skull base
    https://www.sciencedaily.com/releases/2024/04/240417131055.htm

  • EurekAlert! (Japan)，2024.04

    "Analysis of Genome Changes Contributing to the Characteristic Cranial Base Morphology in Homo sapiens ― Single Nucleotide Polymorphism in the Chromosome 22q11.2 Region Evolved from Neanderthals"
    https://www.eurekalert.org/news-releases/1041357?language=japanese

  • TMDU Press Release，2024.04

    Genetic variant identified that shaped the human skull base
    https://www.tmd.ac.jp/english/press-release/20240412-1/

  • EurekAlert!，2024.04

    Genetic variant identified that shaped the human skull base
    https://www.eurekalert.org/news-releases/1041357/

  • JapaneseResearch.com Press Release，2024.04

    "Analysis of Genome Changes Contributing to the Characteristic Cranial Base Morphology in Homo sapiens ― Single Nucleotide Polymorphism in the Chromosome 22q11.2 Region Evolved from Neanderthals"
    https://research-er.jp/articles/view/132663

  • Tokyo Medical and Dental University (TMDU) Facebook，2024.04

    "Analysis of Genome Changes Contributing to the Characteristic Cranial Base Morphology in Homo sapiens ― Single Nucleotide Polymorphism in the Human Chromosome 22q11.2 Region Evolved from Neanderthals"
    https://www.facebook.com/tmdu.public/posts/pfbid02L47FT6832RcneSC2kGD7giHeV2vMESGXbuzwk7SBoNyoNrZ6VMdjRHPVWakCqCvwl

  • Tokyo Medical and Dental University Press Release (in Japanese)，2024.04

    "Analysis of Genome Changes Contributing to the Characteristic Cranial Base Morphology in Homo sapiens"【Associate Professor Noriko Funato】
    https://www.tmd.ac.jp/press-release/20240412-1/

  • Grants-in-Aid for Scientific Research (C)，2023.04

    "Integrated analysis of single nucleotide polymorphisms associated with "nonsyndromic" cleft lip and palate" Noriko Funato

  • Rights Maintenance (Patent Number: 6989842)，2023

    Novel tripeptide, differentiation inducer for osteoblasts, and bone formation accelerator.
    Nippi Corporation & Tokyo Medical and Dental University

  • Rights Maintenance (Patent Number: 6860877)，2023

    Osteoblast differentiation inducer and bone formation accelerator
    Nippi Corporation & Tokyo Medical and Dental University

  • PR TIMES，2022.10

    Discovered a novel collagen-derived peptide 'Gly-3Hyp-4Hyp'
    https://prtimes.jp/main/html/rd/p/000000010.000083625.html

  • Scholarly Community Encyclopedia，2022.06

    Craniofacial Phenotypes and Genetics of DiGeorge Syndrome
    https://encyclopedia.pub/entry/23098

  • PR TIMES，2021.12

    Continuous intake of collagen peptides may have beneficial effects on lipid metabolism.
    https://prtimes.jp/main/html/rd/p/000000001.000083625.html

  • Unboxing the role of TBX1 in palatal development: a gene profiling study，2020.02

    Atlas of Science - another view of science
    (https://atlasofscience.org)

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Performance of duties 【 display / non-display 】

  • ，2024.02

  • ，2023.06 - 2023.10

  • ，2023.06

  • ，2023.01

  • ，2022.07

  • ，2022.07

  • ，2021.12

  • ，2021.12

  • ，2021.12

  • ，2021.09

  • ，2021.06 - 2021.07

  • ，2021.06

  • ，2021.06

  • ，2021.06

  • ，2021.02

  • ，2021.01

  • ，2021.01

  • ，2020.12

  • ，2020.12

  • ，2020.11

  • ，2020.07

  • ，2020.06 - 2020.07

  • ，2020.06

  • ，2020.06

  • ，2020.02

  • ，2019.11

  • ，2019.11

  • ，2019.11

  • ，2019.10

  • ，2019.07

  • ，2019.06 - 2019.07

  • ，2019.05 - 2019.06

  • ，2019.05

  • ，2018.11

  • ，2018.11

  • ，2018.10

  • ，2018.09

  • ，2018.08

  • ，2018.07

  • ，2018.07

  • ，2018.07

  • ，2018.06 - 2018.07

  • ，2018.05

  • ，2017.11

  • ，2017.05

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Social Contribution 【 display / non-display 】

  • The National Institute of Science and Technology Policy (NISTEP): Survey to assess the current state of science, technology, and innovation creation.，2021 - Now

  • Times Higher Education (THE)'s Global Academic Reputation Survey，2021 - 2023

  • QS Global Academic Survey (QS World University Rankings)，2020 - 2023

  • Japanese Association of Oral Biology, Delegate，Japanese Association of Oral Biology，2016.04.01 - Now

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