Personnel Information

写真a

AJIOKA Itsuki


Job title

Professor

Birth date

1973

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4972

Laboratory Fax number

+81-3-5803-4716

Homepage URL

http://www.tmd.ac.jp/cbir/1/ajioka/english/index.html

Research Areas, Keywords

Brain Regeneration, Developmental Neurobiology, Biomaterial Engineering

Field Introduction URL

https://www.tmd.ac.jp/cbir/1/ajioka/english/

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Graduating School 【 display / non-display 】

  • Tokyo Institute of Technology, Faculty of Life Science and Engineering, 1996, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Institute of Technology, Graduate School, Division of Life Science and Engineering, Doctor's Course, 2001, Completed

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Degree 【 display / non-display 】

  • Ph.D.

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Campus Career 【 display / non-display 】

  • 2009.11
    -
    2014.09
    Tokyo Medical and Dental University， Center for Brain Integration Research， Associate Professor
  • 2014.10
    -
    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Brain Integration Research， Associate Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Brain Integration Research， Associate Professor
  • 2017.05
    -
    2020.09
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Brain Integration Research， Associate Professor
  • 2020.10
    -
    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Brain Integration Research， Associate Professor
  • 2022.03
    -
    2024.03
    Tokyo Medical and Dental University， Institute of Research， a， Center for Brain Integration Research， Associate Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Center for Brain Integration Research， Professor

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External Career 【 display / non-display 】

  • 2001.04
    -
    2002.07
    Japan Society for the Promotion of Science, Research Scholar
  • 2002.08
    -
    2005.07
    Keio University School of Medicine, Department of Anatomy, Instructor
  • 2005.08
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    2009.02
    St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Postdoctoral Fellow
  • 2009.03
    -
    2009.10
    Keio University School of Medicine, Center for Integrated Research Medicine, Assistant Professor
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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society for Neurochemistry

  • Asian-Pacific Society for Neurochemistry

  • International Society for Neurochemistry

  • The Japan Neuroscience Society

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Academic Activity 【 display / non-display 】

  • 2019
    -
    Now
    International Society for Neurochemistry Advanced School Sub-Committee, Local-Chair
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Research Areas 【 display / non-display 】

  • Neuroscience-general

  • Biomedical engineering

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Published Papers & Misc 【 display / non-display 】

  1. Uchida N, Ryu Y, Takagi Y, Yoshizawa K, Suzuki K, Anraku Y, Ajioka I, Shimokawa N, Takagi M, Hoshino N, Akutagawa T, Matsubara T, Sato T, Higuchi Y, Ito H, Morita M, Muraoka T. Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery. Journal of the American Chemical Society. 2023.03; 145 (11): 6210-6220. ( PubMed, DOI )

  2. Ohno Y, Nakajima C, Ajioka I, Muraoka T, Yaguchi A, Fujioka T, Akimoto S, Matsuo M, Lotfy A, Nakamura S, Herranz-Pérez V, García-Verdugo JM, Matsukawa N, Kaneko N, Sawamoto K. Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery. Biomaterials. 2023.03; 294 122003. ( PubMed, DOI )

  3. Muraoka T, Ajioka I. Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke. Neurochemical research. 2022.06; 47 (9): 2488-2498. ( PubMed, DOI )

  4. Atsuya Yaguchi, Mio Oshikawa, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka, Itsuki Ajioka. Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration. Nat Commun. 2021.11; 12 (1): 6623. ( PubMed, DOI )

  5. Yaguchi A, Hiramatsu H, Ishida A, Oshikawa M, Ajioka I, Muraoka T. Hydrogel-Stiffening and Non-Cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains. Chemistry (Weinheim an der Bergstrasse, Germany). 2021.06; 27 (36): 9295-9301. ( PubMed, DOI )

  6. Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu H, Linn P, Nagatani N, Yamamura M, Harada K, Horike SI, Inoue H, Yano S, Kumar S, Kitajima S, Ajioka I, Takahashi C. Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy. Hepatology (Baltimore, Md.). 2021.04; 74 (4): 1971-1993. ( PubMed, DOI )

  7. Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka. Sequence-Dependent Bioactivity and Self-Assembling Properties of RGD-Containing Amphiphilic Peptides as Extracellular Scaffolds ACS Applied Bio Materials. 2020.05; 3 (6): 3605-3611. ( PubMed, DOI )

  8. Komabayashi-Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, Ajioka I, Matsushita J, Kidoya H, Takakura N, Okamoto T, Kinoshita K, Ichihashi M, Nagata KI, Ema M, Mizutani KI. Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. Cell reports. 2019.10; 29 (5): 1113-1129.e5. ( PubMed, DOI )

  9. Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I, Yanai N, Kimizuka N. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angewandte Chemie (International ed. in English). 2019.09; 58 (49): 17827-17833. ( PubMed, DOI )

  10. Ishida A, Watanabe G, Oshikawa M, Ajioka I, Muraoka T. Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides. Chemistry (Weinheim an der Bergstrasse, Germany). 2019.07; 25 (59): 13523-13530. ( PubMed, DOI )

  11. Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto. Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. Cell Stem Cell. 2018.01; 22 (1): 128-137. ( PubMed, DOI )

  12. Mio Oshikawa, Kei Okada, Hidenori Tabata, Koh-Ichi Nagata, Itsuki Ajioka. Dnmt1-dependent Chk1 pathway suppression is protective against neuron division. Development. 2017.09; 144 (18): 3303-3314. ( PubMed, DOI )

  13. Mio Oshikawa, Kei Okada, Naoko Kaneko, Kazunobu Sawamoto, Itsuki Ajioka. Affinity-Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain. Adv Healthc Mater. 2017.06; 6 (11): ( PubMed, DOI )

  14. Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, Kazunobu Sawamoto. β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain. EBioMedicine. 2017.02; 16 195-203. ( PubMed, DOI )

  15. Nobutaka Ishizu, Daishi Yui, Akira Hebisawa, Hidenori Aizawa, Wanpeng Cui, Yuko Fujita, Kenji Hashimoto, Itsuki Ajioka, Hidehiro Mizusawa, Takanori Yokota, Kei Watase. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum. Mol. Genet.. 2016.10; 25 (20): 4507-4517. ( PubMed, DOI )

  16. Itsuki Ajioka, Hideo Jinnou, Kei Okada, Masato Sawada, Shinji Saitoh, Kazunobu Sawamoto. Enhancement of Neuroblast Migration into the Injured Cerebral Cortex Using Laminin-Containing Porous Sponge. Tissue Eng Part A. 2014.08; ( PubMed, DOI )

  17. Itsuki Ajioka. Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family. Dev. Growth Differ.. 2014.06; 56 (5): 324-334. ( PubMed, DOI )

  18. Hirofumi Fujita, Hanako Aoki, Itsuki Ajioka, Maya Yamazaki, Manabu Abe, Arata Oh-Nishi, Kenji Sakimura, Izumi Sugihara. Detailed expression pattern of aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice. PLoS ONE. 2014; 9 (1): e86679. ( PubMed, DOI )

  19. Mio Oshikawa, Kei Okada, Kazunori Nakajima, Itsuki Ajioka. Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner. Development. 2013.06; 140 (11): 2310-2320. ( PubMed, DOI )

  20. Itsuki Ajioka, Shizuko Ichinose, Kazunori Nakajima, Hidehiro Mizusawa. Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons. Biomaterials. 2011.09; 32 (25): 5765-5772. ( PubMed, DOI )

  21. Nikia Laurie, Adithi Mohan, Justina McEvoy, Damon Reed, Jiakun Zhang, Brett Schweers, Itsuki Ajioka, Virginia Valentine, Dianna Johnson, David Ellison, Michael A Dyer. Changes in retinoblastoma cell adhesion associated with optic nerve invasion. Mol. Cell. Biol.. 2009.12; 29 (23): 6268-6282. ( PubMed, DOI )

  22. Itsuki Ajioka, Michael A Dyer. A new model of tumor susceptibility following tumor suppressor gene inactivation. Cell Cycle. 2008.03; 7 (6): 735-740. ( PubMed )

  23. Itsuki Ajioka, Rodrigo A P Martins, Ildar T Bayazitov, Stacy Donovan, Dianna A Johnson, Sharon Frase, Samantha A Cicero, Kelli Boyd, Stanislav S Zakharenko, Michael A Dyer. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007.10; 131 (2): 378-390. ( PubMed, DOI )

  24. Yuko Gonda, Hitoshi Sakurai, Yukio Hirata, Hidenori Tabata, Itsuki Ajioka, Kazunori Nakajima. Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain. Gene Expr. Patterns. 2007.02; 7 (4): 431-440. ( PubMed, DOI )

  25. Takuya T Maeda, Itsuki Ajioka, Kazunori Nakajima. Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting. BMC Syst Biol. 2007; 1 43. ( PubMed, DOI )

  26. Itsuki Ajioka, Takuya Maeda, Kazunori Nakajima. Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set. Keio J Med. 2006.09; 55 (3): 107-110. ( PubMed )

  27. Itsuki Ajioka, Takuya Maeda, Kazunori Nakajima. Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development. Eur. J. Neurosci.. 2006.01; 23 (2): 296-308. ( PubMed, DOI )

  28. Itsuki Ajioka, Kazunori Nakajima. Switching of alpha-catenin from alphaE-catenin in the cortical ventricular zone to alphaN-catenin II in the intermediate zone. Brain Res. Dev. Brain Res.. 2005.11; 160 (1): 106-111. ( PubMed, DOI )

  29. Chikako Kudo, Itsuki Ajioka, Yukio Hirata, Kazunori Nakajima. Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain. J. Comp. Neurol.. 2005.07; 487 (3): 255-269. ( PubMed, DOI )

  30. Itsuki Ajioka, Kazunori Nakajima. Birth-date-dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures. Eur. J. Neurosci.. 2005.07; 22 (2): 331-342. ( PubMed, DOI )

  31. Itsuki Ajioka, Toshihiro Akaike, Yoshifumi Watanabe. Ethanolamine is a co-mitogenic factor for proliferation of primary hepatocytes. J. Cell. Biochem.. 2002; 84 (2): 249-263. ( PubMed )

  32. I Ajioka, R Nishio, M Ikekita, T Akaike, M Sasaki, J Enami, Y Watanabe. Establishment of heterotropic liver tissue mass with direct link to the host liver following implantation of hepatocytes transfected with vascular endothelial growth factor gene in mice. Tissue Eng.. 2001.06; 7 (3): 335-344. ( PubMed, DOI )

  33. T Haruyama, I Ajioka, T Akaike, Y Watanabe. Regulation and significance of hepatocyte-derived matrix metalloproteinases in liver remodeling. Biochem. Biophys. Res. Commun.. 2000.06; 272 (3): 681-686. ( PubMed, DOI )

  34. I Ajioka, T Akaike, Y Watanabe. Expression of vascular endothelial growth factor promotes colonization, vascularization, and growth of transplanted hepatic tissues in the mouse. Hepatology. 1999.02; 29 (2): 396-402. ( PubMed, DOI )

  35. Y Watanabe, I Ajioka, T Akaike. Gene transfection of multicellular spheroid of hepatocytes on an artificial substrate. Cytotechnology. 1998.01; 26 (1): 65-78. ( PubMed, DOI )

  36. Y Watanabe, S W Lee, M Detmar, I Ajioka, H F Dvorak. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene. 1997.05; 14 (17): 2025-2032. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  1. Itsuki Ajioka. Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). Wiley-VCH, Weinheim， 2018 Molecular Technology for Injured Brain Regeneration (ISBN : 978-3-527-34162-7)

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Conference Activities & Talks 【 display / non-display 】

  1. Itsuki Ajioka. Injured Brain Regeneration Using Supramolecular Peptide Hydrogels. ISN-APSN 2nd Online School "Modelling Brain Disorders" 2022.12.22 online

  2. 味岡 逸樹. 脳梗塞後の血管新生を促進する超分子ペプチドゲルの分子設計と開発. 第44回日本分子生物学会年会 2022.12.01 千葉

  3. Itsuki Ajioka. Injured brain regeneration using supramolecular peptide hydrogels. 第60回日本生物物理学会年会 2022.09.29 函館

  4. Itsuki Ajioka, Atsuya Yaguchi, Mio Oshikawa, Go Watanabe, Takahiro Muraoka. Jigsaw-shaped self-assembling peptide (JigSAP) hydrogels efficiently incorporate and release VEGF and promote brain regeneration . 2022 ISN-APSN Meeting 2022.08.29

  5. Itsuki Ajioka, Takahiro Muraoka, Go Watanabe. JigSAP (jigsaw-shaped self-assembling peptide) for regenerative medicine of the subacute phase of ischemic stroke. Neuro2022 2022.06.30 沖縄

  6. Itsuki Ajioka. Artificial Scaffolds Mimicking the Extracellular Environment of Developing Brain. the 16th Meeting of the Asian-Pacific Society for Neurochemistry 2021.12.14

  7. Itsuki Ajioka, Takahiro Muraoka, Go Watanabe. Viscoelasticity-modulated supramolecular peptides for regenerative medicine of ischemic stroke. 第44回日本分子生物学会年会 2021.12.03

  8. Itsuki Ajioka. Cell Cycle and Biomaterial Engineering for Injured Brain Regeneration. Invited lecture 2020.01.29 Pune (India)

  9. Itsuki Ajioka. Cell Cycle and Biomaterial Engineering for Injured Brain Regeneration. Invited lecture 2020.01.28 Pune (India)

  10. Itsuki Ajioka. Cell Cycle Dysregulation: Understanding Neuropathology of Degeneration and Tumor. 第17回Annual Meeting of Indian Academy of Neurosciences 2019.11.20 New Delhi (India)

  11. Itsuki Ajioka, Yoichi Sasaki, Mio Oshikawa, Nobuhiro Yanai. Near-infrared optogenetics by photon upconversion hydrogels. 第11回光操作研究会 2019.09.11 名古屋

  12. Itsuki Ajioka, Mio Oshikawa, Yoichi Sasaki, Nobuhiro Yanai. Near-infrared optogenetics by photon upconversion hydrogels. ISN-ASN Meeting 2019.08.07

  13. Itsuki Ajioka. Molecular technology regulating the vascular environment for injured brain regeneration. Neuro2019 2019.07.28

  14. Itsuki Ajioka. Biomaterial engineering for angiogenesis after ischemic stroke. 第61回日本神経化学会大会・第40回日本生物学的精神医学会・合同年会 2018.09.08

  15. Itsuki Ajioka. Biomaterial Engineering for Injured Brain Regeneration. 15th Meeting of the Asian-Pacific Society for Neurochemistry 2018.08.27

  16. 味岡逸樹, 押川未央. Angiogenic Scaffold Engineering for Injured Brain Regeneration. 第41回日本神経科学大会 2018.07.26 神戸

  17. Itsuki Ajioka, Mio Oshikawa. Cell division of hypoxic-ischemic cortical neurons by overriding mitotic safeguards. Neuroscience 2016 2016.11.13 サンディエゴ（米国）

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Awards & Honors 【 display / non-display 】

  • The Award for Young Investigator of Japanese Society for Neurochemistry，2008

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Others 【 display / non-display 】

  • Jigsaw-Shaped Peptide Solves Tissue Regeneration Puzzle，2022.01

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