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ISHIKAWA Tomonori
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Graduating School 【 display / non-display 】
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Tokyo Medical and Dental University, Faculty of Medicine, 1997, Graduated
Graduate School 【 display / non-display 】
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Tokyo Medical and Dental University, Doctor's Course, 2006, Completed
Campus Career 【 display / non-display 】
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2007.01-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Comprehensive Reproductive Medicine, Assistant Professor
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2017.01-2017.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Pediatrics, Perinatal and Maternal Medicine, Junior Associate Professor
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2017.04-2019.09Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Pediatrics, Perinatal and Maternal Medicine, Junior Associate Professor
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2019.10-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Pediatrics, Perinatal and Maternal Medicine, Associate Professor
Published Papers & Misc 【 display / non-display 】
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Mitsui J, Ibayashi M, Aizawa R, Ishikawa T, Miyasaka N, Tsukamoto S. Lipid droplets synthesized during luteinization are degraded after pregnancy. The Journal of reproduction and development. 2024.04; 70 (2): 72-81. ( PubMed, DOI )
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Shiori Kumazawa, Kazuki Saito, Nanako Hashido, Rinko Ibi, Tomonori Ishikawa, Akira Wakabayashi, Naoyuki Miyasaka. Reinfusion of peritoneal fluid elevates the level of plasma D-dimer in patients with early-onset ovarian hyperstimulation syndrome. Reproductive Medicine and Biology. 2024.02; 23 (1): e12563. ( PubMed, DOI )
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Kidera N, Ishikawa T, Kawamura T, Miyasaka N. Maternal body mass index is not associated with assisted reproductive technology outcomes. Scientific reports. 2023.09; 13 (1): 14817. ( PubMed, DOI )
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Higashide R, Saito K, Hashido N, Ishikawa T, Miyasaka N. Step-by-step instructions for detecting whirlpool sign in adnexal torsion. Journal of rural medicine : JRM. 2023.07; 18 (3): 189-193. ( PubMed, DOI )
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Junichiro Mitsui, Kiyotaka Kawai, Makiko Tajima, Kenichiro Hiraoka, Viviane Casaroli, Yoshimi Sato, Yoshiaki Furusawa, Tomonori Ishikawa, Naoyuki Miyasaka. Effects of Hydrosalpinx on Endometrial Receptivity and Uterine Microbiome: An Interesting Case of Double Uterus with Unilateral Hydrosalpinx Endocrines. 2022.12; 3 (4): 821-830.
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Kidera N, Ishikawa T, Kawamura T, Miyasaka N. Impact of paternal age on IVF and pregnancy outcomes with only normal sperm parameters. Taiwanese journal of obstetrics & gynecology. 2022.11; 61 (6): 1015-1020. ( PubMed, DOI )
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Mitsutoshi Yamada, Tomonori Ishikawa, Takeshi Iwasa, Hajime Oishi, Satoko Osuka, Kenji Oka, Shuichi Ono, Masanori Ono, Makoto Orisaka, Haruhiko Kanasaki, Yasushi Kawano, Kazuhiro Kawamura, Hiroshi Kishi, Fuminori Kimura, Shinnosuke Kuroda, Akira Kuwahara, Hideyuki Kobayashi, Akira Komiya, Hidekazu Saito, Kenji Sato, Suguru Sato, Koji Shiraishi, Hiromitsu Shirasawa, Tatsuya Suzuki, Yasushi Takai, Seido Takae, Toshifumi Takahashi, Tsuyoshi Takiuchi, Masahito Tachibana, Isao Tamura, Hiroshi Tamura, Seung Chik Jwa, Tsuyoshi Baba, Miyuki Harada, Tetsuya Hirata, Atsushi Fukui, Yusuke Fukuda, Shinichiro Fukuhara, Tetsuo Maruyama, Yasushi Yumura, Osamu Yoshino, Yasushi Hirota, Akira Tsujimura, Naoaki Kuji, Yutaka Osuga. Guidelines for Reproductive Medicine in Japan. Reprod Med Biol. 2022.08; 21 (1): e12483. ( PubMed, DOI )
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Kenichiro Hiraoka, Nozomi Uchida, Tomonori Ishikawa and Kiyotaka Kawai. Value of Meiotic Spindle Imaging on Fertilization and Embryo Development Following Human Oocyte Piezo-ICSI Fertility & Reproduction. 2022; 4 (1): 26-31. ( DOI )
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Tatsumi Takayuki, Sampei Makiko, Saito Kazuki, Honda Yuka, Okazaki Yuka, Arata Naoko, Narumi Kanako, Morisaki Naho, Ishikawa Tomonori, Narumi Satoshi. Age-Dependent and Seasonal Changes in Menstrual Cycle Length and Body Temperature Based on Big Data OBSTETRICS AND GYNECOLOGY. 2020.10; 136 (4): 666-674. ( PubMed, DOI )
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Yoshida T, Saito K, Kawamura T, Ishikawa T, Kato T, Matsubara K, Miyasaka N, Miyado M, Fukami M. Circulating steroids and mood disorders in patients with polycystic ovary syndrome. Steroids. 2020.10; 165 108748. ( PubMed, DOI )
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Saito Kazuki, Mano Chihiro, Tatsumi Takayuki, Ishikawa Tomonori, Sekiguchi Masaki, Iwahara Yuki, Hiramitsu Shiro, Miyasaka Naoyuki. Placenta accrete after a frozen-thawed embryo transfer in a systemic lupus erythematosus patient treated with hydroxychloroquine GYNECOLOGICAL ENDOCRINOLOGY. 2020.09; 36 (9): 843-846. ( PubMed, DOI )
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Yoshino Y, Yoshiki N, Nakamura R, Iwahara Y, Ishikawa T, Miyasaka N. Large leiomyomatosis peritonealis disseminata after laparoscopic myomectomy: A case report with literature review. International journal of surgery case reports. 2020; 77 866-869. ( PubMed, DOI )
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Saito Kazuki, Kuwahara Akira, Ishikawa Tomonori, Morisaki Naho, Miyado Mami, Miyado Kenji, Fukami Maki, Miyasaka Naoyuki, Ishihara Osamu, Irahara Minoru, Saito Hidekazu. Reply: Artificial cycle 'per se' or the specific protocol of endometrial preparation as responsible for obstetric complications of frozen cycle? HUMAN REPRODUCTION. 2019.12; 34 (12): 2554-2555. ( PubMed, DOI )
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Hiraoka Kenichiro, Tatsumi Takayuki, Tajima Makiko, Ishikawa Tomonori, Kawai Kiyotaka. EFFECTS OF MEIOTIC SPINDLE IMAGING IN HUMAN OOCYTES FOLLOWING PIEZO-ICSI ON OOCYTE FERTILIZATION AND EMBRYO DEVELOPMENT. FERTILITY AND STERILITY. 2019.09; 112 (3): E274.
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Asghari A, Ishikawa T, Hiramitsu S, Lee WR, Umetani J, Bui L, Korach KS, Umetani M. 27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-induced Inflammatory Signaling. Endocrinology. 2019.08; ( PubMed, DOI )
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Saito Kazuki, Kuwahara Akira, Ishikawa Tomonori, Morisaki Naho, Miyado Mami, Miyado Kenji, Fukami Maki, Miyasaka Naoyuki, Ishihara Osamu, Irahara Minoru, Saito Hidekazu. Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus HUMAN REPRODUCTION. 2019.08; 34 (8): 1567-1575. ( DOI )
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Fusegi A, Oshima N, Nakasuji T, Ishikawa T, Wakana K, Yoshiki N, Miyasaka N. Port site recurrence and unusual diffuse subcutaneous metastases of unexpected early stage ovarian cancer after laparoscopic surgery: a case report. Journal of rural medicine : JRM. 2019.05; 14 (1): 143-147. ( PubMed, DOI )
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Fusegi Atsushi, Oshima Noriko, Nakasuji Takashi, Ishikawa Tomonori, Wakana Kimio, Yoshiki Naoyuki, Miyasaka Naoyuki. Port site recurrence and unusual diffuse subcutaneous metastases of unexpected early stage ovarian cancer after laparoscopic surgery: a case report(和訳中) Journal of Rural Medicine. 2019.05; 14 (1): 143-147. ( ichushi )
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Nakasuji Takashi, Kawai Kiyotaka, Ishikawa Tomonori, Teraoka Kaori, Takeuchi Shiho, Miyagawa Tomoko, Nara Kazuko, Kidera Nobuyuki, Harada Tatsuya, Miyasaka Naoyuki. Random-start ovarian stimulation with aromatase inhibitor for fertility preservation in women with Japanese breast cancer(和訳中) Reproductive Medicine and Biology. 2019.04; 18 (2): 167-172. ( ichushi )
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Nakasuji Takashi, Kawai Kiyotaka, Ishikawa Tomonori, Teraoka Kaori, Takeuchi Shiho, Miyagawa Tomoko, Nara Kazuko, Kidera Nobuyuki, Harada Tatsuya, Miyasaka Naoyuki. Random-start ovarian stimulation with aromatase inhibitor for fertility preservation in women with Japanese breast cancer REPRODUCTIVE MEDICINE AND BIOLOGY. 2019.04; 18 (2): 167-172. ( DOI )
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Ishihara Osamu, Jwa Seung Chik, Kuwahara Akira, Ishikawa Tomonori, Kugu Koji, Sawa Rintaro, Banno Kouji, Irahara Minoru, Saito Hidekazu. Assisted reproductive technology in Japan: A summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology(和訳中) Reproductive Medicine and Biology. 2019.01; 18 (1): 7-16. ( ichushi )
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Ishihara Osamu, Jwa Seung Chik, Kuwahara Akira, Ishikawa Tomonori, Kugu Koji, Sawa Rintaro, Banno Kouji, Irahara Minoru, Saito Hidekazu. Assisted reproductive technology in Japan: A summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology REPRODUCTIVE MEDICINE AND BIOLOGY. 2019.01; 18 (1): 7-16. ( DOI )
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Hiraoka K, Kitamura S, Otsuka Y, Kawai K, Harada T, Ishikawa T. Effects of sperm direction in Piezo-ICSI on oocyte survival, fertilization, embryo development and implantation ability in humans: A preliminary study. Journal of Obstetrics and Gynaecology Research. 2018.10;
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Hiramitsu S, Ishikawa T, Lee WR, Khan T, Crumbley C, Khwaja N, Zamanian F, Asghari A, Sen M, Zhang Y, Hawse JR, Minna JD, Umetani M.. Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Frontier Endocrinology. 2018.08;
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Hiraoka K., Otsuka Y., Kawai K., Harada T., Ishikawa T.. Effects of sperm direction (head first injection, tail first injection) in Piezo-ICSI on oocyte survival, fertilization and embryo morphokinetics in humans HUMAN REPRODUCTION. 2018.07; 33 239-240.
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Saito K., Kuwahara A., Ishikawa T., Nakasuji T., Miyado M., Miyado K., Fukami M., Miyasaka N., Irahara M., Saito H.. Pregnancy after frozen-thawed embryo transfer during hormonal replacement cycle is associated with hypertensive disorders of pregnancy and placenta accreta HUMAN REPRODUCTION. 2018.07; 33 129.
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Kawai K, Ishikawa T, Ohuchi K, Kidera K. Kawahara M, Hiraoka K, Ogawa O, Masuzawa M, Harada T, Miyasaka N. WHO Group1 ovulation disorder successfully treated with recombinant follicle stimulating hormone: A revisit to the role of luteinizing hormone and estradiol Journal of Medical and Dental Sciences. 2018.06;
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Kawai K, Harada T, Ishikawa T, Sugiyama R, Kawamura T, Yoshida A, Tsutsumi O, Ishino F, Kubota T, Kohda T. Parental age and gene expression profiles in individual human blastocysts. Scientific reports. 2018.02; 8 (1): 2380. ( PubMed, DOI )
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Saito H, Jwa SC, Kuwahara A, Saito K, Ishikawa T, Ishihara O, Kugu K, Sawa R, Banno K, Irahara M. Assisted reproductive technology in Japan: a summary report for 2015 by The Ethics Committee of The Japan Society of Obstetrics and Gynecology Reproductive Medicine and Biology. 2017.12; ( DOI )
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Saito K., Kawai K., Tatsumi K., Miyado M., Katsumi M., Nakamura S., Ishikawa T., Miyasaka N., Fukami M.. POR mutations as novel genetic causes of female infertility due to partial 17 alpha-hydroxylase deficiency HUMAN REPRODUCTION. 2017.07; 32 104-105.
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Irahara M, Kuwahara A, Iwasa T, Ishikawa T, Ishihara O, Kugu K, Sawa R, Banno K and Saito H.. Assisted reproductive technology in Japan: a summary report of 1992–2014 by the Ethics Committee, Japan Society of Obstetrics and Gynecology Reproductive Medicine and Biology. 2017.04; 16 126-132.
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Saito K, Miyado K, Yamatoya K, Kuwahara A, Inoue E, Miyado M, Fukami M, Ishikawa T, Saito T, Kubota T, Saito H.. Increased incidence of post-term delivery and Cesarean section after frozen-thawed embryo transfer during a hormone replacement cycle. Journal of Assisted Reproduction and Genetics.. 2017.01; 34 465-470.
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Umetani Michihisa, Ghosh Pritam, Ishikawa Tomonori, Umetani Junko, Ahmed Mohamed, Mineo Chieko, Shaul Philip W. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab. 2014.07; 20 (1): 172-182. ( PubMed, DOI )
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Lee WR, Ishikawa T, Umetani M.. The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol. Clin Lipidol.. 2014.06; 9 (6): 617-624.
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Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW.. 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep.. 2013.11; 5 (3): 637-645.
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Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW, Umetani M. . LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity. J Clin Invest.. 2013.08; 123 (8): 3488-3497.
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Tajima M, Harada T, Ishikawa T, Iwahara Y, Kubota T.. Augmentation of arginase Ⅱ expression in the human endometrial epithelium in the secretory phase. J Med Dent Sci.. 2012.12; 59 (4): 75-82.
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Shimizu Y, Minaguchi R, Ishikawa T, Harada T, Yoshiki N, Kubota T.. Increase in the concentration of cytosolic-free calcium induced by human follicular fluid was decreased in single human spermatozoon with abnormal morphology. 2008.07; 143-149.
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Ishikawa T, Harada T, Kubota T, Aso T.. Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro. Reproduction.. 2007.06; 133 (6): 1233-1239.
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Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T.. Identification of arginase in human placental villi. Placenta.. 2007.02; 28 (2-3): 133-138.
Conference Activities & Talks 【 display / non-display 】
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Tomonori Ishikawa. Personalized Embryo Transfer improves implantation rate in patients with RIF. 1st Igenomix APAC Online Symposium 2020.09.27 web
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Hiramitsu Shiro, Ishikawa Tomonori, Umetani Michihisa, Miyasaka Naoyuki. エストロゲン受容体β介在性27-ヒドロキシコレステロールによる肺癌細胞増殖の制御(Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol). The Journal of Obstetrics and Gynaecology Research 2019.08.01
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Saitou Kazuki, Ishikawa Tomonori, Tatsumi Kenichi, Nakasuji Takashi, Hiramitsu Shiro, Iwahara Yuki, Miyasaka Naoyuki. 出産に成功したP450酸化還元酵素欠損症患者(Successful delivery of a patient with P450 oxidoreductase deficiency). The Journal of Obstetrics and Gynaecology Research 2019.08.01
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K. Kawai, M. Kawahara, N. Kidera, K. Teraoka, A. Yamamoto, K. Ohuchi, Y. Iwahara, T. Ishikawa, T. Harada, N. Miyasaka. EFFICACY OF LUTEAL PHASE (LP) -COS AND FOLLICULAR AND LUTEAL PHASE OVARIAN STIMULATION DURING THE SAME MENSTRUAL CYCLE (DUOSTIM) IN BREAST CANCER PATIENTS . the 7th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2017) 2017.11.19 Kuala Lumpur
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K. Hiraoka, Y. Otsuka, T. Ishikawa, K. Kawai, T. Harada. Effect the sperm selection magnification (400x vs 1,200x) on fertilization results and embryo development in human Piezo-ICSI. ASRM 73rd Scientific Congress 2017.10.28 San Antonio
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Masaki Iwamoto, Satoko Yazaki,Tomonori Ishikawa, Kiyotaka Kawai,Kenichiro Hiraoka. Effects of different sperm immobilization method on the in vitro development of porcine ICSI embryos. World Congress of Reproductive Biology 2017 2017.09.27 Okinawa
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Kazuki Saito, Kiyotaka Kawai, Kenichi Tatsumi, Mami Miyado, Momori Katsumi, Shigeru Nakamura, Tomonori Ishikawa, Naoyuki Miyasaka, Maki Fukami. POR mutations as novel genetic causes of female infertility due to partial 17 alpha hydroxylase deficiency . ESHRE 2017 annual meeting 2017.07.05 Geneva
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Miyuki Nonaka, Tomonori Ishikawa, Sachi Murakata, Nobuyuki Kidera, Atsushi Yamamoto, Yuki Iwahara, Naoyuki Miyasaka.. Piezo ICSI improves fertilization rate and good-quality day3 embryo as compared with conventional ICSI. . 7th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2017) 2017.04.01
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K. Hiraoka, M. Saito, A. Kuga, T. Kaji, A. Ichihashi, T. Suhara, M. Ibayashi, T. Tamaki, K. Miyata, Y. Ohtsuka, K. Ohuchi, T. Ishikawa, T. Harada, K. Kawai. IMPACT OF MOVING SPEED OF ICSI NEEDLE INSIDE THE OOCYTE ON SURVIVAL AND FERTILIZATION IN HUMAN ICSI . 7th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2017) 2017.04.01
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K. Kawai, M. Kawahara, N. Kidera, K. Teraoka, A. Yamamoto, K. Ohuchi, Y. Iwahara, T. Ishikawa, T. Harada, N. Miyasaka. EFFICACY OF LUTEAL PHASE (LP) -COS AND FOLLICULAR AND LUTEAL PHASE OVARIAN STIMULATION DURING THE SAME MENSTRUAL CYCLE (DUOSTIM) IN BREAST CANCER PATIENTS . 7th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2017) 2017.03.31
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Ishikawa T, Nonaka M, Murakata S, Kidera N, Yamamoto A, Iwahara Y, Miyasaka N. Fertility preservation at Tokyo Medical and Dental University: Our 1year experience Asian Society for Fertility Preservation. The 1st Asia congress on fertility preservation 2016.11.19
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Kawai Kiyotaka, Ohuchi Kumi, Nara K, Miyagawa T, Kidera Nobuyuki, Iwahara Yuki, Yamamoto Atsushi, Ishikawa Tomonori, Kawahara Mami, Teraoka K, Harada Tatsuya. Efficacy of Random-start Controlled Ovarian Stimulation in Breast Cancer Patients. The 1st Asia congress on fertility preservation 2016.11.19
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木寺信之 石川智則 山本篤 大内久美 川井清考. 運動精子を認め妊娠に至ったimmotile cilia 症候群の1 例. 第61回日本生殖医学会学術講演会 2016.11.03
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Ishikawa T, Kubota T. 27-hydroxycholesterol promotes estrogen receptor positive breast cancer. 68th Annual Congress of Japan Society of Obstetrics and Gynecology, Tokyo 2016.04.22
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Kuwahara A, Ishikawa T, Ishihara O, Kugu K, Sawa R, Banno K, Saito H, Irahara M. Assisted Reproductive Technology(ART)in Japan 2013. Annual report of Japan ART registry. 68th Annual Congress of Japan Society of Obstetrics and Gynecology 2016.04.22 Tokyo