Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023.04; 220 (4): e20221221. ( PubMed, DOI )

Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits. Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol. 2022.10; 23 (1): 1-2. ( PubMed, DOI )

Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed, DOI )

Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.. Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol. 2021.12;

Ohteki T, Kawamura S, Onai N.. Commitment to dendritic cells and monocytes. Int Immunol.. 2021.11;

Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T.. An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Front Immunol.. 2021.02; 12 618081..

Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep. 2020.09; 10 (1): 14639. ( PubMed, DOI )

Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T.. CD86-based analysis enables observation of bona fide hematopoietic responses Blood.. 2020.09; 136 (10): 1144-1154.

Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. . 2020.08; 22 (8): 919-926.

Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep. 2020.05; 10 (1): 8308. ( PubMed, DOI )

Jumpei Asano, Taku Sato, Toshiaki Ohteki. Autophagy Detection in Intestinal Stem Cells. Methods Mol Biol. 2020; 2171 115-125. ( PubMed, DOI )

Hiroyuki Tezuka, Toshiaki Ohteki. Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells. Front Immunol. 2019.08; 10 1891. ( PubMed, DOI )

Takahiro Adachi, Soichiro Yoshikawa, Hiroyuki Tezuka, Noriko M Tsuji, Toshiaki Ohteki, Hajime Karasuyama, Toshihiko Kumazawa. Propolis induces Ca2+ signaling in immune cells. Bioscience of microbiota, food and health. 2019.08; 38 (4): 141-149. ( PubMed, DOI )

Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama. Role of eosinophils in a murine model of inflammatory bowel disease. Biochem. Biophys. Res. Commun.. 2019.03; 511 (1): 99-104. ( PubMed, DOI )

Shunsuke Kawamura, Toshiaki Ohteki. Monopoiesis in humans and mice. Int. Immunol.. 2018.10; 30 (11): 503-509. ( PubMed, DOI )

Y Nakanishi, T Sato, K Takahashi, T Ohteki. IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo. Mucosal Immunol. 2018.05; 11 (3): 871-880. ( PubMed, DOI )

Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki. Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int. Immunol.. 2017.12; 29 (10): 443-456. ( PubMed, DOI )

Kenshiro Matsuda, Noriko Okamoto, Masatoshi Kondo, Peter D Arkwright, Kaoru Karasawa, Saori Ishizaka, Shinichi Yokota, Akira Matsuda, Kyungsook Jung, Kumiko Oida, Yosuke Amagai, Hyosun Jang, Eiichiro Noda, Ryota Kakinuma, Koujirou Yasui, Uiko Kaku, Yasuo Mori, Nobuyuki Onai, Toshiaki Ohteki, Akane Tanaka, Hiroshi Matsuda. Mast cell hyperactivity underpins the development of oxygen-induced retinopathy. J. Clin. Invest.. 2017.11; 127 (11): 3987-4000. ( PubMed, DOI )

Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki. Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed, DOI )

Niken Adiba Nadya, Hiroyuki Tezuka, Toshiaki Ohteki, Satoshi Matsuda, Miyuki Azuma, Shigenori Nagai. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.07; 152 (3): 507-516. ( PubMed, DOI )

Shunsuke Kawamura, Nobuyuki Onai, Fuyuki Miya, Taku Sato, Tatsuhiko Tsunoda, Kazutaka Kurabayashi, Satoshi Yotsumoto, Shoko Kuroda, Katsuto Takenaka, Koichi Akashi, Toshiaki Ohteki. Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017.05; 46 (5): 835-848.e4. ( PubMed, DOI )

Takayuki Yokoi, Kentarou Yokoi, Kazumasa Akiyama, Takashi Higuchi, Yohta Shimada, Hiroshi Kobayashi, Taku Sato, Toshiaki Ohteki, Makoto Otsu, Hiromitsu Nakauchi, Hiroyuki Ida, Toya Ohashi. Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. Mol. Genet. Metab.. 2016.11; 119 (3): 232-238. ( PubMed, DOI )

Jiajia Liu, Yong-Mei Guo, Nobuyuki Onai, Hideaki Ohyagi, Makoto Hirokawa, Naoto Takahashi, Hiroyuki Tagawa, Kumi Ubukawa, Isuzu Kobayashi, Hiroyuki Tezuka, Yoshihiro Minamiya, Toshiaki Ohteki, Kenichi Sawada. Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2016.04; 22 (4): 627-636. ( PubMed, DOI )

Nobuyuki Onai, Toshiaki Ohteki. Isolation of Dendritic Cell Progenitor and Bone Marrow Progenitor Cells from Mouse. Methods Mol. Biol.. 2016.01; 1423 53-59. ( PubMed, DOI )

Hiroshi Kobayashi, Chiharu I Kobayashi, Ayako Nakamura-Ishizu, Daiki Karigane, Hiroshi Haeno, Kimiyo N Yamamoto, Taku Sato, Toshiaki Ohteki, Yoshihiro Hayakawa, Glen N Barber, Mineo Kurokawa, Toshio Suda, Keiyo Takubo. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015.04; 11 (1): 71-84. ( PubMed, DOI )

Y Nakanishi, T Sato, T Ohteki. Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization. Mucosal Immunol. 2015.01; 8 (1): 152-160. ( PubMed, DOI )

Nobuyuki Onai, Toshiaki Ohteki. Bipotent or Oligopotent? A Macrophage and DC Progenitor Revisited. Immunity. 2014.07; 41 (1): 5-7. ( PubMed, DOI )

A Yokota-Nakatsuma, H Takeuchi, Y Ohoka, C Kato, S-Y Song, T Hoshino, H Yagita, T Ohteki, M Iwata. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014.07; 7 (4): 786-801. ( PubMed, DOI )

Takayuki Sato, Toshio Kitawaki, Haruyuki Fujita, Makoto Iwata, Tomonori Iyoda, Kayo Inaba, Toshiaki Ohteki, Suguru Hasegawa, Kenji Kawada, Yoshiharu Sakai, Hiroki Ikeuchi, Hiroshi Nakase, Akira Niwa, Akifumi Takaori-Kondo, Norimitsu Kadowaki. Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃. J Immunol. 2013.09; 191 (6): 3152-3160. ( PubMed, DOI )

Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Müller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013.09; 39 (3): 584-598. ( PubMed, DOI )

Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013.06; 13 (6): 711-722. ( PubMed, DOI )

Nobuyuki Onai, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Noriko Toyama-Sorimachi, Kouji Matsushima, Kayo Inaba, Toshiaki Ohteki. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity. 2013.05; 38 (5): 943-957. ( PubMed, DOI )

Taku Sato, Mahoko Ikeda, Satoshi Yotsumoto, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Toya Ohashi, Toshio Suda, Toshiaki Ohteki. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013.04; 121 (16): 3267-3273. ( PubMed, DOI )

Akihiko Ichikawa, Keiji Kuba, Masayuki Morita, Shinsuke Chida, Hiroyuki Tezuka, Hiromitsu Hara, Takehiko Sasaki, Toshiaki Ohteki, V Marco Ranieri, Claudia C dos Santos, Yoshihiro Kawaoka, Shizuo Akira, Andrew D Luster, Bao Lu, Josef M Penninger, Stefan Uhlig, Arthur S Slutsky, Yumiko Imai. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 2013.01; 187 (1): 65-77. ( PubMed, DOI )

Jiajia Liu, Yong-Mei Guo, Makoto Hirokawa, Keiko Iwamoto, Kumi Ubukawa, Yoshihiro Michishita, Naohito Fujishima, Hiroyuki Tagawa, Naoto Takahashi, Weiguo Xiao, Junsuke Yamashita, Toshiaki Ohteki, Kenichi Sawada. A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells. Exp Hematol. 2012.04; 40 (4): 330-341. ( PubMed, DOI )

Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi. Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed, DOI )

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Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed, DOI )

Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki. Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed, DOI )

Hiroyuki Tezuka, Toshiaki Ohteki. A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed, DOI )

Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada. CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed, DOI )

Hiroyuki Tezuka, Toshiaki Ohteki. Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed, DOI )

Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki. Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed, DOI )

Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe. IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed, DOI )

Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed, DOI )

Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed, DOI )

Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz. IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed, DOI )

Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel. Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay, Markus G Manz. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007.11; 8 (11): 1207-1216. ( PubMed, DOI )

Toshiaki Ohteki. The dynamics of dendritic cell: mediated innate immune regulation. Allergol Int. 2007.09; 56 (3): 209-214. ( PubMed, DOI )

Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature. 2007.08; 448 (7156): 929-933. ( PubMed, DOI )

Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki. The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed, DOI )

Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed, DOI )

Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed, DOI )

Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo. Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed, DOI )

Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed, DOI )

Kaisa Holmberg, Sanjeev Mariathasan, Toshiaki Ohteki, Pamela S Ohashi, Nicholas R J Gascoigne. TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol. 2003.09; 171 (5): 2427-2434. ( PubMed )

Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, Tadatsugu Taniguchi. Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA. 2003.09; 100 (19): 10872-10877. ( PubMed, DOI )

Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003.06; 423 (6941): 762-769. ( PubMed, DOI )

Samuel D Saibil, Toshiaki Ohteki, Forest M White, Mark Luscher, Arsen Zakarian, Alisha Elford, Jeffery Shabanowitz, Hiroshi Nishina, Patrice Hugo, Josef Penninger, Brian Barber, Donald F Hunt, Pamela S Ohashi. Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 2003.03; 33 (3): 685-696. ( PubMed, DOI )

Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki, Shigeo Koyasu. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003.03; 4 (3): 280-286. ( PubMed, DOI )

Yukie Murata, Toshiaki Ohteki, Shigeo Koyasu, Junji Hamuro. IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol. 2002.10; 32 (10): 2866-2873. ( PubMed, DOI )

Toshiaki Ohteki. Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi. Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed, DOI )

T Ohteki, K Suzue, C Maki, T Ota, S Koyasu. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed, DOI )

T Ohteki, C Maki, S Koyasu. Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

T Ohteki, S Koyasu. Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

T Ohteki, A Hessel, M F Bachmann, A Zakarian, E Sebzda, M S Tsao, K McKall-Faienza, B Odermatt, P S Ohashi. Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol. 1999.09; 29 (9): 2886-2896. ( PubMed, DOI )

T Ohteki, T Fukao, K Suzue, C Maki, M Ito, M Nakamura, S Koyasu. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med. 1999.06; 189 (12): 1981-1986. ( PubMed )

T Ohteki, C Maki, S Koyasu, T W Mak, P S Ohashi. Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999.04; 162 (7): 3753-3756. ( PubMed )

E Sebzda, S Mariathasan, T Ohteki, R Jones, M F Bachmann, P S Ohashi. Selection of the T cell repertoire. Annu Rev Immunol. 1999.01; 17 829-874. ( PubMed, DOI )

S Mariathasan, M F Bachmann, D Bouchard, T Ohteki, P S Ohashi. Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol. 1998.12; 161 (11): 6030-6037. ( PubMed )

T Ohteki, H Yoshida, T Matsuyama, G S Duncan, T W Mak, P S Ohashi. The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med. 1998.03; 187 (6): 967-972. ( PubMed )

H Yoshida, H Nishina, H Takimoto, L E Marengère, A C Wakeham, D Bouchard, Y Y Kong, T Ohteki, A Shahinian, M Bachmann, P S Ohashi, J M Penninger, G R Crabtree, T W Mak. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 1998.01; 8 (1): 115-124. ( PubMed )

T Ohteki, S Ho, H Suzuki, T W Mak, P S Ohashi. Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development. J Immunol. 1997.12; 159 (12): 5931-5935. ( PubMed )

M F Bachmann, T Ohteki, K M Faienza, A Zakarian, D Kägi, D E Speiser, P S Ohashi. Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis. J Immunol. 1997.11; 159 (9): 4165-4170. ( PubMed )

M Shimamura, T Ohteki, U Beutner, H R MacDonald. Lack of directed V alpha 14-J alpha 281 rearrangements in NK1+ T cells. Eur J Immunol. 1997.06; 27 (6): 1576-1579. ( PubMed, DOI )

M Shimamura, T Ohteki, P Launois, A M Garcia, H R MacDonald. Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol. 1997.04; 158 (8): 3682-3689. ( PubMed )

U Beutner, P Launois, T Ohteki, J A Louis, H R MacDonald. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997.04; 27 (4): 928-934. ( PubMed, DOI )

DE Speiser, E Sebzda, T Ohteki, M F Bachmann, K Pfeffer, TW Mak, PS Ohashi. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol.. 1996.12; 26 (12): 3055-3060. ( PubMed, DOI )

T Ohteki, H R MacDonald. Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver. J. Exp. Med.. 1996.03; 183 (3): 1277-1282. ( PubMed )

T Ohteki, A Wilson, S Verbeek, H R MacDonald, H Clevers. Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice. Eur. J. Immunol.. 1996.02; 26 (2): 351-355. ( PubMed, DOI )

P Launois, T Ohteki, K Swihart, H R MacDonald, J A Louis. In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-. Eur. J. Immunol.. 1995.12; 25 (12): 3298-3307. ( PubMed, DOI )

P R Walker, T Ohteki, J A Lopez, H R MacDonald, J L Maryanski. Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J. Immunol.. 1995.10; 155 (7): 3443-3452. ( PubMed )

T Ohteki, M Iwamoto, S Izui, H R MacDonald. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur. J. Immunol.. 1995.01; 25 (1): 37-41. ( PubMed, DOI )

T Ohteki, H R MacDonald. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J. Exp. Med.. 1994.08; 180 (2): 699-704. ( PubMed )

J P Rosat, M Schreyer, T Ohteki, G A Waanders, H R MacDonald, J A Louis. Selective expansion of activated V delta 4+ cells during experimental infection of mice with Leishmania major. Eur. J. Immunol.. 1994.02; 24 (2): 496-499. ( PubMed, DOI )

N Koyamada, T Ohteki, T Abo, T Fukumori, N Ohkouchi, S Satomi, Y Taguchi, A Kusumi, S Mori, K Kumagai. Induction of specific tolerance by hepatic double-negative CD4-8- alpha beta T cells of mice immunized with allogeneic cells via the portal vein in vivo [corrected]. Cell. Immunol.. 1993.06; 149 (1): 107-116. ( PubMed )

T Ohteki, H R MacDonald. Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur. J. Immunol.. 1993.06; 23 (6): 1251-1255. ( PubMed, DOI )

T Ohteki, S Okamoto, M Nakamura, E Nemoto, K Kumagai. Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice. Immunol. Lett.. 1993.05; 36 (2): 145-152. ( PubMed )

T Ohteki, T Abo, A Kusumi, T Sasaki, S Shibata, S Seki, K Kumagai. Age-associated increase of CD5+ B cells in the liver of autoimmune (NZB x NZW) F1 mice. Microbiol. Immunol.. 1993.01; 37 (3): 221-228. ( PubMed )

T Iiai, H Watanabe, S Seki, K Sugiura, K Hirokawa, M Utsuyama, H Takahashi-Iwanaga, T Iwanaga, T Ohteki, T Abo. Ontogeny and development of extrathymic T cells in mouse liver. Immunology. 1992.12; 77 (4): 556-563. ( PubMed )

A Kusumi, T Abo, T Masuda, K Sugiura, S Seki, T Ohteki, R Okuyama, K Kumagai. Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy. Immunology. 1992.10; 77 (2): 177-184. ( PubMed )

T Ohteki, R Okuyama, S Seki, T Abo, K Sugiura, A Kusumi, T Ohmori, H Watanabe, K Kumagai. Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol.. 1992.09; 149 (5): 1562-1570. ( PubMed )

T Abo, A Kusumi, S Seki, T Ohteki, K Sugiura, T Masuda, H Rikiishi, T Iiai, K Kumagai. Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell. Immunol.. 1992.06; 142 (1): 125-136. ( PubMed )

R Okuyama, T Abo, S Seki, T Ohteki, K Sugiura, A Kusumi, K Kumagai. Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med.. 1992.03; 175 (3): 661-669. ( PubMed )

H Watanabe, K Ohtsuka, M Kimura, Y Ikarashi, K Ohmori, A Kusumi, T Ohteki, S Seki, T Abo. Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods. 1992.02; 146 (2): 145-154. ( PubMed )

T Masuda, T Ohteki, T Abo, S Seki, S Nose, H Nagura, K Kumagai. Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice. J. Immunol.. 1991.11; 147 (9): 2907-2912. ( PubMed )

S Seki, T Abo, K Sugiura, T Ohteki, T Kobata, H Yagita, K Okumura, H Rikiishi, T Masuda, K Kumagai. Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells. Cell. Immunol.. 1991.10; 137 (1): 46-60. ( PubMed )

T Abo, T Ohteki, S Seki, N Koyamada, Y Yoshikai, T Masuda, H Rikiishi, K Kumagai. The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J. Exp. Med.. 1991.08; 174 (2): 417-424. ( PubMed )

S Seki, T Abo, T Ohteki, K Sugiura, K Kumagai. Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J. Immunol.. 1991.08; 147 (4): 1214-1221. ( PubMed )

T Ohteki, T Abo, S Seki, T Kobata, H Yagita, K Okumura, K Kumagai. Predominant appearance of gamma/delta T lymphocytes in the liver of mice after birth. Eur. J. Immunol.. 1991.07; 21 (7): 1733-1740. ( PubMed, DOI )

J Satoh, H Seino, S Shintani, S Tanaka, T Ohteki, T Masuda, T Nobunaga, T Toyota. Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha. J. Immunol.. 1990.09; 145 (5): 1395-1399. ( PubMed )

S Seki, T Abo, T Masuda, T Ohteki, A Kanno, K Takeda, H Rikiishi, H Nagura, K Kumagai. Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts. J. Clin. Invest.. 1990.08; 86 (2): 409-415. ( PubMed, DOI )

T Ohteki, S Seki, T Abo, K Kumagai. Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice. J. Exp. Med.. 1990.07; 172 (1): 7-12. ( PubMed )

Toshiaki Ohteki. Analysis of lymphoproliferative disorders in autoimmune model mouse (MRL-lpr/lpr) accompanying Sjögren’s syndrome. Tohoku Univ Dent J. 1990.01; 9 73-82.

J Satoh, H Seino, T Abo, S Tanaka, S Shintani, S Ohta, K Tamura, T Sawai, T Nobunaga, T Oteki. Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest.. 1989.10; 84 (4): 1345-1348. ( PubMed, DOI )

Masashi Kanayama, Toshiaki Ohteki. B cell: an amplifier of myeloid cell production triggered by infection. 第51回日本免疫学会学術集会 2022.12.09 熊本

Shun Ishikawa, Taku Sato, Toshiaki Ohteki.. Transcriptional mechanisms responsible for functional alteration of microglia in aging and Alzheimer's disease.. 50th Annual Meeting of the Japanese Society for Immunology 2021.12.10 Nara

Yuta Izumi, Masashi Kanayama, Toshiaki Ohteki . A Therapeutic Strategy That Selectively Targets Human Monocyte Progenitors for Solid Cancers and Leukemias. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.10 Nara

Masahi Kanayama、Yuta Izumi, Toshiaki Ohteki . Myeloid-like B cells boost emergency myelopoiesis during infection.. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.08 Nara

Shun Ishikawa. Elucidation of transcriptional regulation mechanism of age-related microglia. The 27th International Symposium on Molecular Cell Biology of Macrophages.. The 27th International Symposium on Molecular Cell Biology of Macrophages. 2021.06.16 web

Shun Isikawa, Taku Sato, Toshiaki Ohteki . Elucidation of transcriptional regulation mechanism of age-related microglia. . The 27th International Symposium on Molecular Cell Biology of Macrophages. 2021.06.16

Ohteki Toshiaki. Chronic inflammatory milieu causes differentiation and exhaustion of tissue stem cells. . France - Japan Symposium Implications of Senescence in Age Related Disorders:Towards Healthy Aging 2019.09.05 France

Ohteki Toshiaki. Clonal hematopoiesis and radiation-associated diseases. Radiation Effects Research Foundation International Workshop 2019.01.10 Hiroshima

Toshiaki Ohteki. Adaptive differentiation of dendritic cell progenitors in tissue microenviroments.. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.12 Fukuoka

Ohteki Toshiaki. From NKT cells to antigen-presenting cells and beyond. . Symposium in honor of Rob MacDonald 2018.09.12 Switzerland

Ohteki Toshiaki. Identification of human common monocyte progenitor, cMoP. KEY Forum 2018 Stem Cell Traits and Developmental Systems 2018.01.12 Kumamoto

Ohteki Toshiaki. Identification of human cMoP.. The 5th Annual meeting of the International Cytokine and Interferon Society 2017.11.01 金沢市

Ohteki Toshiaki. Identification of a human progenitor with strict monocyte differentiation potential: A counterpart of mouse cMoPs. The 79th Annual Meeting of the Japanese Society of Hematology 2017.10.21 Tokyo

Ohteki T. Identification of mononuclear phagocyte progenitors. The 44th Annual Meeting of the Japanese Society for Immunology 2015.11.18 Sapporo

Ohteki T.. Identity and flexibility of common dendritic cell progenitor＋. 4th Europian Congress of Immunology 2015.09.09 Wien

Ohteki T. . Dendritic cell and immune regulation. . The 2014 Fall Conference of the KAI 2014.11.06 Seoul

Ohteki T. Novel Source of Dendritic Cells, the Control Tower of the Immune System. . 2014 Agricultural Biotechnology Symposium, Biomaterials and Immune Modulation 2014.11.05 Seoul

Ohteki T. . Novel Source of Dendritic Cells, the Control Tower of the Immune System. . Novo Nordisk Innavation Summit Tokyo 2014 2014.10.01 Tokyo

Ohteki T.. A novel source of dendritic cells, the control tower of the immune system.. The 2nd International Symposium of Research Center for Cellular Homeostasis 2014. 2014.06.20 Seoul

Ohteki T. Discovdry of a novel source of dendritic celss, the control tower of the immune system. 2013 Annual Meeting of the Japanese Scoiety for Immunology 2013.12.11 Chiba

Ohteki T. New DC Progenitors with Prominent pDC Differentiation Potential. KEYSTONE SYMPOSIA on Molecular and Cellular Biology(2013) 2013.03.06 Keyston, USA

Ohteki T. Role for monocyte-derived cells in fine-tuning excessive immune responses. The 12th International Symposium on Dendritic Cells 2012.10.09 Daegu, Korea

Ohteki T. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. The 11h Awaji International Forum on Infection and Immunity 2012.09.14 Awaji-shi, Hyogo

Ohteki T. Role for plasmacytoid dendritic cells in gut IgA induction. . The 4th Symposium for the MEXT Priority Research on Immunological Self　 2012.01.28 Kyoto

Ohteki T. Role for plasmacytoid dendritic cells in gut IgA induction. CFCD3rd International pDC Workshop 2011.12.08 Paris

Ohteki T. Prominent fole for pDCs in mucosal IgA induction. . The 6th Chiba University Global COE Symposium Immune System Regulation toward Disease Control 2011.11.30 Chiba

Ohteki T, Ohyagi H, Sawada K and Onai N. Dendritic. Dendritic cells hemophagocytose to fine-tune immune responses. The 6th International Symposium of Institute Network. The 6th International Symposium of Institute Network. 2011.06.09 Tokyo

樗木俊聡. インターフェロンによる造血幹細胞の運命決定制御. 第100回日本病理学会ワークショップ13　 2011.04.30 横浜市

Ohteki T. Regulatory role of interferon in HSC homeostasis-an old cytokine with a new function. ESF-JSPS Frontier Science Conference Series for Young Researchers. 2011.03.02 Hulshorst, Netherlands

Ohteki T. Regulatory role of interferon in HSC homeostasis.. 69th Annual Meeting of the Japanese Cancer Association. 2010.09.23 Osaka

Ohteki T. Interferons wake up sleeping hematopoietic stem cells. 9th Surugadai International Symposium. 2010.09.08 Tokyo

Ohteki T. Reguratory Role of Interferons in HSC Homeostasis　. The 1st JSH International Symposium 2010 2010.07.16 Akita

Ohteki T. Regulation of mucosal IgA production by dendritic cells. The 2nd International Symposium of WPI-IFReC “Dynamics of Immune Responses” 2009.02.13 Osaka