Personnel Information

写真a

TAGA Tetsuya


Job title

Professor

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Laboratory Phone number

+81-3-5803-5814

Laboratory Fax number

+81-3-5803-5814

Mail Address

The inquiry by e-mail is 《here》

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

Stem Cell Biology, Neural Stem Cell, Hematopoietic Stem Cell, Cancer Stem Cell

Profile

Professor Tetsuya Taga's research at the Department of Stem Cell Regulation has been conducted to elucidate the mechanisms by which stem cells are regulated. The major focus has been on neural stem cells, hematopoietic stem cells, and cancer stem cells. The study is aimed to understand development, maintenance, and regeneration of the central nervous system and the hematopoietic system, and to obtain a clue to tackle the problem of cancer recurrence. Particular attention is given to cell-external cues (such as cytokines) and cell-intrinsic programs (including chromatin modification), taking cross-interactions of transcriptional regulatory signals into consideration.
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Graduating School 【 display / non-display 】

  • Kyoto University, Faculty of Science, Biology: Plant Physiology, 1982, Graduated

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Graduate School 【 display / non-display 】

  • Osaka University, Graduate School, Division of Medicine, Pathology: Immunology, Doctor's Course, 1988, Completed

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Degree 【 display / non-display 】

  • Ph.D., Osaka University

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Campus Career 【 display / non-display 】

  • 2008.12
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Stem Cell Regulation， Professor
  • 2013.04
    -
    2020.03
    Tokyo Medical and Dental University， Board Member， Vice President
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Cell Biology， Professor
  • 2022.05
    -
    2024.09
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Stem Cell Regulation， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， -， Department of Stem Cell Regulation， Professor
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External Career 【 display / non-display 】

  • 1987.04
    -
    1989.03
    Japan Society for the Promotion of Science, Institute for Molecular and Cellular Biology, Osaka University, Research Fellow
  • 1989.04
    -
    1989.10
    Osaka University, Institute for Molecular and Cellular Biology, Research Fellow
  • 1989.11
    -
    1996.06
    Osaka University, Institute for Molecular and Cellular Biology, Assistant Professor
  • 1996.07
    -
    1996.08
    Osaka University, Institute for Molecular and Cellular Biology, Accociate Professor
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University, Medical Research Institute,
  • 2000.09
    -
    2008.12
    Kumamoto University, Institute of Molecular Embryology and Genetics, Professor

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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society of Inflammation and Regeneration

  • Japanese Society for Immunology

  • The Japanese Society for Regenerative Medicine

  • The Japanese Cancer Association

  • The Molecular Biology Society of Japan

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Academic Activity 【 display / non-display 】

  • 2013.04
    -
    2025.07
    The Japanese Society of Inflammation and Regeneration Director
  • 2002.07
    -
    2025.07
    The Japanese Society of Inflammation and Regeneration Councillor
  • 1995.01
    -
    2024.12
    Japanese Society for Immunology Council Member
  • 2001.05
    -
    2018.10
    The Japanese Society for Regenerative Medicine A delegate
  • 2004.04
    -
    2006.03
    Member, Education and Research Council, Kumamoto University
  • 2008.04
    -
    2008.09
    Member, Education and Research Council, Kumamoto University
  • 2004.04
    -
    2006.03
    Member, President Nomination Committee, Kumamoto University
  • 2001.10
    -
    2006.03
    Director, Institute of Molecular Embryology and Genetics, Kumamoto University
  • 2008.04
    -
    2008.09
    Director, Institute of Molecular Embryology and Genetics, Kumamoto University
  • 2002.10
    -
    2007.03
    Leader, 21st Century Center-Of-Excellence, MEXT
  • 2007.06
    -
    2008.06
    Leader, Global Center-Of-Excellence, MEXT
  • 2001 (October)-2006 (March)
  • Director, Institute of Molecular Embryology and Genetics, Kumamoto University
  • 2002 (October)-2007 (March)
  • Leader, 21st Century Center-Of-Excellence, MEXT (Ministry of Education, Culture, Sports, Science and Technology)
  • 2004 (April)-2006 (March)
  • Member, Education and Research Council, Kumamoto University
  • 2004 (April)-2006 (March)
  • Member, President Nomination Cmmittee, Kumamoto University
  • 2007 (June)-2008 (August)
  • Leader, Global Center-Of-Excellence, MEXT
  • 2008 (April)-2008 (September)
  • Director, Institute of Molecular Embryology and Genetics, Kumamoto University
  • 2008 (April)-2008 (September)
  • Member, Education and Research Council, Kumamoto University
  • 2008 (April)-2008 (September)
  • Member, President Nomination Cmmittee, Kumamoto University
  • 2009 (April)-2014 (March)
  • Head, Division of Advanced Molecular Medicine, Medical Research Institute, Tokyo Medical and Dental University
  • 2012 (April)-2013 (March)
  • Executive Advisor to the President, Tokyo Medical and Dental University
  • 2013 (April)-present
  • Vice-President for Public Relations, Tokyo Medical and Dental University
  • 2008.04
    -
    2008.09
    Member, President Nomination Committee, Kumamoto University

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Research Areas 【 display / non-display 】

  • Stem Cell Biology

  • Molecular Regulation of Stem Cells

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Research Theme 【 display / non-display 】

  • Molecular Regulation of Stem Cells

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Published Papers & Misc 【 display / non-display 】

  1. Tanakorn Tarapongpun, Nattawat Onlamoon, Kouichi Tabu, Suebwong Chuthapisith, Tetsuya Taga. The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells. Genes Cells. 2024.03; 29 (3): 231-253. ( PubMed, DOI )

  2. Murota Y, Nagane M, Wu M, Santra M, Venkateswaran S, Tanaka S, Bradley M, Taga T, Tabu K. A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells. Inflammation and regeneration. 2023.09; 43 (1): 46. ( PubMed, DOI )

  3. Melig Gerel, Nobuhisa Ikuo, Saito Kiyoka, Tsukahara Ryota, Itabashi Ayumi, Kanai Yoshiakira, Kanai-Azuma Masami, Osawa Mitsujiro, Oshima Motohiko, Iwama Atsushi, Taga Tetsuya. A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo Inflammation and Regeneration. 2023.08; 43 (1): 41. ( PubMed, DOI )

  4. Kashiwagi Taichi, Takazawa Yuuki, Kagawa Tetsushi, Taga Tetsuya. Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia Inflammation and Regeneration. 2023.02; 43 (1): 8. ( PubMed, DOI )

  5. Wenqian Wang, Kouichi Tabu, Alapati Aimaitijiang, Tetsuya Taga. Therapy-resistant nature of cancer stem cells in view of iron metabolism Inflammation and Regeneration. 2022.11; 42 (1): 34.

  6. Tabu Kouichi, Taga Tetsuya. Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells Inflammation and Regeneration. 2022.11; 42 (1): 54. ( PubMed, DOI )

  7. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas Cells. 2022.06; 11 (13): 2054.

  8. Aimaitijiang Alapati, Tabu Kouichi, Wang Wenqian, Nobuhisa Ikuo, Taga Tetsuya. Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells GENES TO CELLS. 2022.01; 27 (1): 25-42. ( PubMed, DOI )

  9. Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Takeda S, Kato K. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Scientific Reports. 2021.02; 11 (1): 4220.

  10. Anani M, Nobuhisa I, Taga T. Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway. Journal of Cancer Prevention. 2020.12; 25 (4): 204-212. ( PubMed, DOI )

  11. Takahashi S, Nobuhisa I, Saito K, Melig G, Itabashi A, Harada K, Osawa M, Endo AT, Iwama A,Taga T. Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos Differentiation. 2020.09; 115 53-61. ( DOI )

  12. Tabu K, Liu W, Kosaku A, Terashima K, Murota Y, Aimaitijiang A, Nobuhisa I, Hide T, Taga T. Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages. Stem cells (Dayton, Ohio). 2020.08; 38 (8): 921-935. ( PubMed, DOI )

  13. Nobuhisa Ikuo, Saito Kiyoka, Tsukahara Ryota, Azuma Koya, Melig Gerel, Itabashi Ayumi, Taga Tetsuya. Hematopoiesis and Immune Environment　Involvement of TET1 inthe maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  14. 椨 康一, 田賀 哲也. グリオーマの新規治療標的としての単球動員がん幹細胞の可視化と検証(Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells) 日本癌学会総会記事. 2019.09; 78回 P-3064. ( ichushi )

  15. AIMAITIJIANG ALAPATI, 椨 康一, 田賀 哲也. グリオーマ幹細胞によるマウス骨髄赤芽球分化の促進(Glioma stem cells modulate erythropoiesis in mouse bone marrow) 日本癌学会総会記事. 2019.09; 78回 P-3065. ( ichushi )

  16. Tabu Kouichi, Taga Tetsuya. A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance CANCER SCIENCE. 2018.12; 109 1308.

  17. 椨 康一, 田賀 哲也. グリオーマにおける単球動員亜集団は幹細胞性と薬剤耐性を有する(A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance) 日本癌学会総会記事. 2018.09; 77回 2314. ( ichushi )

  18. Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, and Taga T . Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis Exp Cell Res. 2018.04; 365 (1): 145-155. ( DOI )

  19. Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa.. Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes. Mol Biol Cell. 2018.01; 29 209-219. ( DOI )

  20. Murota Yoshitaka, Tabu Kouichi, Taga Tetsuya. Establishment of glioma mouse model by transducing oncogenic H-RasV12 gene into the p53 deficient astrocytes CANCER SCIENCE. 2018.01; 109 631.

  21. Tabu Kouichi, Murota Yoshitaka, Taga Tetsuya. Self-expanding strategies of glioma stem cells that involves macrophages to adapt to iron-deprivation stress CANCER SCIENCE. 2018.01; 109 1046.

  22. 齋藤 清香, 信久 幾夫, 田賀 哲也. マウス胎生中期AGM領域の未分化血球系細胞塊におけるSox17とTETファミリーによる未分化性維持機構の解明 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0781]. ( ichushi )

  23. Ikuo Nobuhisa, Takahishi Satomi, Saito Kiyoka, Taga Tetsuya. 癌免疫療法における免疫応答　妊娠中期マウス胚の大動脈内造血細胞クラスター形成における転写因子Sox17によって誘導される接着分子の役割(Hematopoiesis and immune environments　Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-G. ( ichushi )

  24. 室田 吉貴, 椨 康一, 田賀 哲也. p53ノックアウトマウスアストロサイトへのH-RasV12導入によるマウスグリオーマモデルの樹立 日本癌学会総会記事. 2017.09; 76回 P-2120. ( ichushi )

  25. 椨 康一, 室田 吉貴, 田賀 哲也. グリオーマ幹細胞のマクロファージを利用した鉄欠乏ストレスへの適応・生存戦略 日本癌学会総会記事. 2017.09; 76回 P-3156. ( ichushi )

  26. Harada K, Nobuhisa I, Anani M, Saito K, Taga T. Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( DOI )

  27. Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI, and Taga T. Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. Sci Rep. 2017.02; 7 42070. ( PubMed, DOI )

  28. Murota Y, Tabu K, and Taga T. Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes. BMC Cancer. 2016.11; 16 847. ( PubMed, DOI )

  29. 椨 康一, 王 文茜, 室田 吉貴, 田賀 哲也. C6グリオーマ幹細胞におけるマクロファージ誘導を介した鉄枯渇への適応 日本癌学会総会記事. 2016.10; 75回 J-1031. ( ichushi )

  30. 王 文茜, 椨 康一, 萩谷 祐一郎, 室田 吉貴, 小倉 俊一郎, 田賀 哲也. アミノレブリン酸を用いたC6グリオーマ幹細胞の検出に対する鉄キレート剤による向上効果 日本癌学会総会記事. 2016.10; 75回 E-1107. ( ichushi )

  31. Kimura T, Wang L, Tabu K, Tsuda M, Tanino M, Maekawa A, Nishihara H, Hiraga H, Taga T, Oda Y, and Tanaka S. Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells. Oncogene. 2016.07; 35 3932-3943.

  32. Kimura T., Wang L., Tabu K., Tsuda M., Tanino M., Maekawa A., Nishihara H., Hiraga H., Taga T., Oda Y., Tanaka S.. Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells ONCOGENE. 2016.07; 35 (30): 3932-3943. ( DOI )

  33. Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, and Taga T. A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( PubMed, DOI )

  34. Sudo G, Kagawa T, Kokubu Y, Inazawa J, and Taga T. Increase of GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Genes Cells. 2016.03; 21 218-225. ( DOI )

  35. Kokubu Y, Tabu K, Wang W, Muramatsu N, Murota Y, Nobuhisa I, Jinushi M, and Taga T. Induction of protumoral CD11chigh macrophages by glioma cancer stem cells through GM-CSF. Genes Cells. 2016.03; 21 241-251. ( PubMed, DOI )

  36. Sudo Genki, Kagawa Tetsushi, Kokubu Yasuhiro, Inazawa Johji, Taga Tetsuya. Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice GENES TO CELLS. 2016.03; 21 (3): 218-225. ( PubMed, DOI )

  37. Inagaki T, Kusunoki S, Tabu K, Okabe H, Yamada I, Taga T, Matsumoto A, Makino S, Takeda S, and Kato K. Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo. Hum Cell. 2016.01; 29 10-21.

  38. Inagaki Tetsunori, Kusunoki Soshi, Tabu Kouichi, Okabe Hitomi, Yamada Izumi, Taga Tetsuya, Matsumoto Akemi, Makino Shintaro, Takeda Satoru, Kato Kiyoko. Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo HUMAN CELL. 2016.01; 29 (1): 10-21. ( PubMed, DOI )

  39. Inagaki Tetsunori, Kusunoki Soshi, Tabu Kouichi, Okabe Hitomi, Yamada Izumi, Taga Tetsuya, Matsumoto Akemi, Makino Shintaro, Takeda Satoru, Kato Kiyoko. ヒトの栄養膜細胞株HTR-8/SVneo由来のサイドポピュレーション細胞におけるリンパ球抗原6複合体の発現亢進(Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo) Human Cell. 2016.01; 29 (1): 10-21. ( ichushi )

  40. 齋藤 清香, 信久 幾夫, Anani Maha, 原田 果歩, 高橋 聡美, 田賀 哲也. マウス胎生期成体型造血の場AGM領域の未分化血球系細胞塊におけるSox17-Notch1-Hes1経路による未分化性維持 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P0983]. ( ichushi )

  41. 椨 康一, 村松 希美, 田賀 哲也. 人工ニッチポリマーの応用による鉄貯蔵/腫瘍随伴マクロファージの誘導を介するグリオーマ幹細胞の環境適応戦略の解明 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P1039]. ( ichushi )

  42. 王 文茜, 椨 康一, 国分 康博, 萩谷 祐一郎, 小倉 俊一郎, 田賀 哲也. C6グリオーマ幹細胞を移植したマウスに観察された異常脾臓造血とその特性解明 日本癌学会総会記事. 2015.10; 74回 E-1146. ( ichushi )

  43. Nobuhisa Ikuo, Saito Kiyoka, Takahashi Satomi, Harada Kaho, Anani Maha, Taga Tetsuya. 造血と免疫系微小環境　Sox17は、Notchシグナル伝達を介し、大動脈-性腺-中腎領域における大動脈内造血細胞クラスタの幹細胞集団を維持する(Hematopoiesis and microenvironments for immune system　Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region through Notch signaling) 日本免疫学会総会・学術集会記録. 2015.10; 44 (Proceedings): 147. ( ichushi )

  44. Saito Kiyoka, Nobuhisa Ikuo, Anani Maha, Harada Kaho, Takahashi Satomi, Taga Tetsuya. MAINTENANCE OF HEMATOPOIETIC STEM AND PROGENITOR CELL PHENOTYPE OF INTRA-AORTIC CELL CLUSTERS IN THE AGM REGION THROUGH THE SOX17-NOTCH1-HES1 AXIS EXPERIMENTAL HEMATOLOGY. 2015.09; 43 (9): S92.

  45. Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Harada Kaho, Anani Maha, Saito Kiyoka, Takagi Haruna, Takahashi Satomi, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya. SOX17 IS CRITICAL FOR THE MAINTENANCE OF STEM CELL PHENOTYPE OF INTRA-AORTIC HEMATOPOIETIC CLUSTERS OF CELLS IN THE AORTA-GONAD-MESONEPHROS REGION EXPERIMENTAL HEMATOLOGY. 2015.09; 43 (9): S85.

  46. Inagaki Tetsunori, Kato Kiyoko, Kusunoki Soshi, Tabu Koichi, Okabe Hitomi, Yamada Izumi, Taga Tetsuya, Matsumoto Akemi, Takezawa Toshiaki, Makino Shintaro, Takeda Satoru. IDENTIFICATION AND CHARACTERIZATION OF HTR-8/SVNEO SP CELLS. PLACENTA. 2014.10; 35 (10): A6.

  47. 國分 康博, 椨 康一, 王 文茜, バグダディ・ムハンマド , 地主 将久, 田賀 哲也. C6グリオーマ癌幹細胞由来GM-CSFはCD11c high CD204(+)腫瘍促進性マクロファージを誘導する(C6 glioma stem cell-derived GM-CSF induces CD11chighCD204(+) protumoral macrophages) 日本癌学会総会記事. 2014.09; 73回 P-1176. ( ichushi )

  48. 椨 康一, 國分 康博, 田賀 哲也. 癌幹細胞ニッチの自己構築における自発的オートスキジスの関与の検討(Autoschizic cancer cell death and its implications to cancer stem cell niche) 日本癌学会総会記事. 2014.09; 73回 P-1167. ( ichushi )

  49. 王 文茜, 椨 康一, 萩谷 祐一郎, 小倉 俊一郎, 田賀 哲也. 非癌幹細胞由来ヘムの赤血球分化へ与える影響(Roles of cancer-derived heme in erythropoiesis: implications for erythroid niche for cancer stem cells) 日本癌学会総会記事. 2014.09; 73回 P-1168. ( ichushi )

  50. Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya. Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ. 2014.08; 56 (6): 469-479. ( PubMed, DOI )

  51. Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya. 骨髄に限定された分化能を持つ調節因子候補としてのSox17(Sox17 as a candidate regulator of myeloid restricted differentiation potential) Development, Growth & Differentiation. 2014.08; 56 (6): 469-479. ( ichushi )

  52. Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Kishikawa Yoko, Anani Maha, Harada Kaho, Takagi Haruna, Saito Kiyoka, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014.06; 34 (11): 1976-1990. ( PubMed, DOI )

  53. Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, and Taga T. A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem Cells. 2014.06; 32 (6): 1602-1615. ( PubMed, DOI )

  54. Khajuria A., Tabu K., Taga T.. Glioma stem cells exploit host astrocytes to enhance tumour migratory and invasive capacity BRITISH JOURNAL OF SURGERY. 2014.05; 101 36-37.

  55. Nobuhisa Ikuo, Osawa Mitsujiro, Harada Kaho, Anani Maha, Saito Kiyoka, Takagi Haruna, Iwama Atsushi, Taga Tetsuya, Uemura Mami, Kanai Yoshiaki, Kanai-Azuma Masami. Sox17形質導入細胞移植マウスの骨髄細胞を移植したレシピエントの分析(Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice) 日本免疫学会総会・学術集会記録. 2013.11; 42 (Proceedings): 70. ( ichushi )

  56. 椨 康一, 村松 希美, 田賀 哲也. 人工ポリマーを用いたC6グリオーマ幹細胞ニッチの同定(Polymer-based identification of cancer stem cell niche for C6 glioma) 日本癌学会総会記事. 2013.10; 72回 141. ( ichushi )

  57. Kusunoki Soshi, Kato Kiyoko, Tabu Kouichi, Inagaki Tetsunori, Okabe Hitomi, Kaneda Hiroshi, Suga Shin, Terao Yasuhisa, Taga Tetsuya, Takeda Satoru. The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecol Oncol. 2013.06; 129 (3): 598-605. ( PubMed, DOI )

  58. Uemura Mami, Ozawa Aisa, Nagata Takumi, Kurasawa Kaoruko, Tsunekawa Naoki, Nobuhisa Ikuo, Taga Tetsuya, Hara Kenshiro, Kudo Akihiko, Kawakami Hayato, Saijoh Yukio, Kurohmaru Masamichi, Kanai-Azuma Masami, Kanai Yoshiakira. Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013.02; 140 (3): 639-648. ( PubMed, DOI )

  59. Tabu Kouichi, Bizen Norihisa, Taga Tetsuya, Tanaka Shinya. Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues. Adv Exp Med Biol. 2013; 777 73-85. ( PubMed, DOI )

  60. Nobuhisa Ikuo, Osawa Mitsujiro, Harada Kaho, Takagi Haruna, Iwama Atsushi, Taga Tetsuya. 造血系の発生とリンパ血液系へのコミットメント　大動脈-性腺-中腎領域からの造血細胞クラスターはSox17の過剰発現により長期再構築能を示す(Hematopoietic cell clusters from the aorta-gonad-mesonephros region exhibited long-term repopulating ability by overexpression of Sox17) 日本免疫学会総会・学術集会記録. 2012.11; 41 126. ( ichushi )

  61. Kagawa T., Kinoshita S., Phillips G., Tomiyoshi S., Bizen N., Shimizu T., Taga T.. Role of glycogen synthase kinase 3 beta in neuronal migration during corticogenesis JOURNAL OF NEUROCHEMISTRY. 2012.10; 123 39.

  62. 村松 希美, 椨 康一, 田賀 哲也. C6グリオーマSP細胞はマウス骨髄由来単球系細胞のマクロファージへの分化を誘導する(C6 glioma side population cells induce differentiation of bone marrow-derived monocyte lineage cells into macrophages) 日本癌学会総会記事. 2012.08; 71回 289. ( ichushi )

  63. 椨 康一, 田賀 哲也. 人工ニッチを用いた腫瘍幹細胞の不均一性の解析(Functional heterogeneity within a tumor stem cell population identified by the synthetic polymer niche) 日本癌学会総会記事. 2012.08; 71回 316. ( ichushi )

  64. Nobuhisa Ikuo, Yamasaki Shoutarou, Ramadan Ahmed, Taga Tetsuya. CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region. Exp Cell Res. 2012.04; 318 (6): 705-715. ( PubMed, DOI )

  65. Nobuhisa Ikuo, Kishikawa Yuko, Anai Maha, Taga Tetsuya. 造血・免疫系形成　SoxFファミリータンパク質にはAGM領域における造血前駆細胞の未分化性を保持する役割がある(SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region) 日本免疫学会総会・学術集会記録. 2011.11; 40 145. ( ichushi )

  66. Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya. Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression. Dev Growth Differ. 2011.09; 53 (7): 870-877. ( PubMed, DOI )

  67. Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya. CD45/c-Kit発現を考慮した造血活動をもつ卵黄細胞集団の同定(Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression) Development, Growth & Differentiation. 2011.09; 53 (7): 870-877. ( ichushi )

  68. 鹿川 哲史, 備前 典久, 柏木 太一, 信久 幾夫, 清水 健史, 田賀 哲也. New insight of functional interactions between neurons and astrocytes　中枢神経系グリア細胞の発生分化研究の現状と展望(New insight of functional interactions between neurons and astrocytes　Specification of glial cell types in the developing central nervous system) 神経化学. 2011.09; 50 (2-3): 150. ( ichushi )

  69. 椨 康一, 田賀 哲也. 合成ポリマーを用いたグリオーマ幹細胞制御(Control of glioma stem cells by the synthetic polymers) 日本癌学会総会記事. 2011.09; 70回 335. ( ichushi )

  70. Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi. 薬剤開発のための新しいトランスジェニックマウスモデル　神経発達障害の新しいマウスモデルの確立(New transgenic mouse models for drug development　Establishment of a new mouse model of neurodevelopmental disorder) Journal of Pharmacological Sciences. 2011.02; 115 (Suppl.1): 35P. ( ichushi )

  71. Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi. Establishment of a new mouse model of neurodevelopmental disorder JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011; 115 35P.

  72. 信久 幾夫, 岸川 陽子, 上村 麻実, Anani Maha, Gomaa Ahmed, 金井 正美, 金井 克晃, 田賀 哲也. 大動脈-生殖隆起-中腎領域由来の造血前駆細胞におけるSox-17の働きが未熟表現型を維持する(Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0895. ( ichushi )

  73. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也. 神経幹/前駆細胞における細胞周期調節因子cyclin D1は細胞周期非依存的にアストロサイト分化を阻害する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle progression) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0876. ( ichushi )

  74. 田賀 哲也. 発生と分化におけるエピジェネティック制御　細胞外の合図と細胞固有のプログラムの相互作用が脳発生を制御する(Epigenetic Regulation in Development and Differentiation　Cross-interactions among cell-external cues and cell-intrinsic programs controlling brain development) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 1S12-1. ( ichushi )

  75. Bizen Norihisa, Shimizu Takeshi, Inoue Toshihiro, Kagawa Tetsushi, Taga Tetsuya. Cross-talk between growth and differentiation pathways in cell fate determination in the developing brain DIFFERENTIATION. 2010.11; 80 S8. ( DOI )

  76. Yoshinaga Yutaka, Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Takada Shinji, Kuratsu Jun-ichi, Taga Tetsuya. Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells. Cell Mol Neurobiol. 2010.10; 30 (7): 1049-1058. ( PubMed, DOI )

  77. Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Nakagata Naomi, Taga Tetsuya. Cells with hematopoietic activity in the mouse placenta reside in side population. Genes Cells. 2010.09; 15 (9): 983-994. ( PubMed, DOI )

  78. 椨 康一, 田賀 哲也. C6グリオーマ細胞株においてMPはSPの維持に寄与する(Main population helps side population in C6 glioma cell line) 日本癌学会総会記事. 2010.08; 69回 232. ( ichushi )

  79. 鹿川 哲史, 清水 健史, 荒木 喜美, 竹田 直樹, 中潟 直巳, 信久 幾夫, 田賀 哲也. 中枢神経系グリア亜集団細胞系譜のGFAP/Creレポーターマウスを用いた解析(Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system) 神経化学. 2010.08; 49 (2-3): 617. ( ichushi )

  80. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也. 神経幹細胞/前駆細胞における細胞周期調節因子cyclin D1のアストロサイト分化抑制機構(Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells) 神経化学. 2010.08; 49 (2-3): 536. ( ichushi )

  81. Inoue Toshihiro, Kagawa Tetsushi, Inoue-Mochita Miyuki, Isono Kyoichi, Ohtsu Naoki, Nobuhisa Ikuo, Fukushima Mikiko, Tanihara Hidenobu, Taga Tetsuya. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010.07; 584 (14): 3233-3238. ( PubMed, DOI )

  82. Tabu Kouichi, Kimura Taichi, Sasai Ken, Wang Lei, Bizen Norihisa, Nishihara Hiroshi, Taga Tetsuya, Tanaka Shinya. Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol Cancer. 2010; 9 39. ( PubMed, DOI )

  83. Kagawa Tetsushi, Shimizu Takeshi, Araki Kimi, Takeda Naoki, Nakagata Naomi, Nobuhisa Ikuo, Taga Tetsuya. Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system NEUROSCIENCE RESEARCH. 2010; 68 E240. ( DOI )

  84. Bizen Norihisa, Inoue Toshihiro, Shimizu Takeshi, Kagawa Tetsushi, Taga Tetsuya. Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells NEUROSCIENCE RESEARCH. 2010; 68 E132. ( DOI )

  85. Fukushima Mikiko, Setoguchi Takao, Komiya Setsuro, Tanihara Hidenobu, Taga Tetsuya. Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2. Int J Dev Neurosci. 2009.11; 27 (7): 685-690. ( PubMed, DOI )

  86. Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Taga Tetsuya. 造血・リンパ器官形成　幹細胞　マウス胚の胎盤において造血活性をもつ細胞の性状解析(Characterization of cells that have hematopoietic activity in the placenta of mouse embryo) 日本免疫学会総会・学術集会記録. 2009.11; 39 49. ( ichushi )

  87. Sanosaka Tsukasa, Namihira Masakazu, Kohyama Jun, Semi Katsunori, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi. 神経前駆細胞にアストロサイト分化能を与えるエピジェネティック機構(Epigenetic mechanism conferring astrocytic potential on neural precursor cells) Neuroscience Research. 2009.09; 65 (Suppl.1): S19. ( ichushi )

  88. 椨 康一, 田賀 哲也. ラットC6グリオーマ細胞株におけるmain populationによるside populationの維持(Maintenance of side population in C6 glioma by main population) 日本癌学会総会記事. 2009.08; 68回 270. ( ichushi )

  89. 鹿川 哲史, 田賀 哲也. アストロサイトの発生と分化　中枢神経系グリア細胞亜集団の細胞系譜解析(Glial cell sub-lineages in the developing central nervous system) 神経化学. 2009.06; 48 (2-3): 167. ( ichushi )

  90. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也. サイクリンD1は神経幹細胞/前駆細胞からの星状細胞分化を細胞周期調節非依存性に抑制する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle regulation) 神経化学. 2009.06; 48 (2-3): 205. ( ichushi )

  91. Namihira Masakazu, Kohyama Jun, Semi Katsunori, Sanosaka Tsukasa, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009.02; 16 (2): 245-255. ( PubMed, DOI )

  92. Sanosaka Tsukasa, Namihira Masakazu, Kohyama Jun, Semi Katsunori, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi. Epigenetic mechanism conferring astrocytic potential on neural precursor cells NEUROSCIENCE RESEARCH. 2009; 65 S19. ( DOI )

  93. Shimizu Takeshi, Kagawa Tetsushi, Inoue Toshihiro, Nonaka Aya, Takada Shinji, Aburatani Hiroyuki, Taga Tetsuya. Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol. 2008.12; 28 (24): 7427-7441. ( PubMed, DOI )

  94. Yamasaki Shoutarou, Nobuhisa Ikuo, Ahmed Gomaa, Taga Tetsuya. 造血　免疫担当細胞初期分化　CD45/c-Kit発現の観点からみた造血能をもつ卵黄嚢細胞の同定(Identification of yolk sac cells having hematopoietic activity in view of CD45/c-Kit expression) 日本免疫学会総会・学術集会記録. 2008.11; 38 134. ( ichushi )

  95. 椨 康一, 木村 太一, 笹井 研, 田賀 哲也, 田中 伸哉. ヒト腫瘍細胞におけるCD133遺伝子の発現メカニズム(The transcriptional mechanism underlying CD133 expression in human tumor cells) 日本癌学会総会記事. 2008.09; 67回 302. ( ichushi )

  96. 鹿川 哲史, 清水 健史, 荒木 喜美, 竹田 直樹, 田賀 哲也. 発達期中枢神経系グリア細胞系譜の解析のためのGFAP/Cre-reporterマウス系の確立(Establishment of GFAP/Cre-reporter mouse system to analyze glial cell sub-lineages in the developing central nervous system) 神経化学. 2008.08; 47 (2-3): 255. ( ichushi )

  97. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也. 神経幹細胞画分における細胞周期調節因子cyclin D1はアストロサイト分化を阻害する(Cyclin D1 inhibits astrocyte differentiation in the section of neural stem cell) 神経化学. 2008.08; 47 (2-3): 245. ( ichushi )

  98. Taga Tetsuya. 神経幹細胞における増殖と分化シグナル伝達経路との交差相互作用(Cross-interactions among growth and differentiation signaling pathways in neural stem cells) Neuroscience Research. 2008.07; 61 (Suppl.1): S19. ( ichushi )

  99. Nobuhisa Ikuo, Yamasaki Shoutarou, Gomaa Ahmed, Taga Tetsuya. 大動脈-性腺-中腎領域における造血活性を持つ細胞集団の同定(Identification of a population of cells having hematopoietic activity in the aorta-gonad-mesonephros region) 日本免疫学会総会・学術集会記録. 2007.10; 37 47. ( ichushi )

  100. Inoue Toshihiro, Kawaji Takahiro, Inoue-Mochita Miyuki, Taga Tetsuya, Tanihara Hidenobu. Media conditioned by retinal pigment epithelial cells suppress the canonical Wnt pathway. Neurosci Lett. 2007.09; 424 (3): 190-193. ( PubMed, DOI )

  101. Kagawa Tetsushi, Yoshinaga Yutaka, Shimizu Takeshi, Inoue Toshihiro, Takada Shinji, Taga Tetsuya. Wnt3aシグナリングによるマウス海馬前駆細胞の細胞周期調節(Wnt3a promotes mouse hippcampal progenitor cell proliferation by shortening cell cycle) 神経化学. 2007.08; 46 (2-3): 409. ( ichushi )

  102. Shimizu Takeshi, Kagawa Tetsushi, Inoue Toshihiro, Takada Shinji, Taga Tetsuya. グリコーゲン合成酵素キナーゼ3βとβ-cateninによる、終脳神経前駆細胞の分裂と分化の調整(A role for glycogen synthase kinase 3β and β-catenin in coordinating proliferation and differentiation of telencephalic neural precursor cells) 神経化学. 2007.08; 46 (2-3): 379. ( ichushi )

  103. Fukuda Shinji, Abematsu Masahiko, Mori Hiroyuki, Yanagisawa Makoto, Kagawa Tetsushi, Nakashima Kinichi, Yoshimura Akihiko, Taga Tetsuya. Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells. Mol Cell Biol. 2007.07; 27 (13): 4931-4937. ( PubMed, DOI )

  104. 福田 信治, 清水 健史, 井上 俊洋, 鹿川 哲史, 田賀 哲也. 幹細胞制御の分子学的基礎　成長中のマウス脳における細胞運命決定の分子学的基礎(Molecular basis for stem cell regulation　Molecular basis for cell-fate determination in the developing mouse brain) 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007.05; 40回・59回 23. ( ichushi )

  105. 清水 健史, 鹿川 哲史, 井上 俊洋, 高田 慎治, 田賀 哲也. 細胞増殖・細胞分化・細胞死・幹細胞　神経前駆細胞の増殖及び分化の調整におけるグリコーゲンシンターゼキナーゼ3βとβ-カテニンの役割(A Role for Glycogen Synthase Kinase 3beta and Beta-Catenin in Coordinating Proliferation and Differentiation of Neural Precursor Cells) 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007.05; 40回・59回 61. ( ichushi )

  106. Nobuhisa Ikuo, Ohtsu Naoki, Okada Seiji, Nakagata Naomi, Taga Tetsuya. Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures. Exp Cell Res. 2007.03; 313 (5): 965-974. ( PubMed, DOI )

  107. Ohtsu Naoki, Nobuhisa Ikuo, Mochita Miyuki, Taga Tetsuya. Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta-gonad-mesonephros hematopoiesis. Exp Cell Res. 2007.01; 313 (1): 88-97. ( PubMed, DOI )

  108. Nobuhisa Ikuo, Ohtsu Naoki, Taga Tetsuya. 造血細胞・リンパ球とリンパ組織の発生分化　培養マウス大動脈-性腺-中腎細胞における造血幹細胞特性を有するサイドポピュレーションの同定(Identification of a side population with hematopoietic stem cell property in cultured mouse aorta-gonad-mesonephros cells) 日本免疫学会総会・学術集会記録. 2006.11; 36 94. ( ichushi )

  109. Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Yoshinaga Yutaka, Taga Tetsuya. 増殖中の神経前駆細胞から分化する神経細胞へ転換する分子機構(A molecular basis of transition from proliferating neural precursor cells to differentiating neurons) 神経化学. 2006.08; 45 (2-3): 337. ( ichushi )

  110. Nakashima Kinichi, Kohyma Jun, Taga Tetsuya, Namihira Masakazu. 神経幹細胞の星状膠細胞分化能のノッチ-誘発性獲得(Notch-induced acquisition of astrocyte differentiation potential of neural stem cells) Neuroscience Research. 2006.07; 55 (Suppl.1): S36. ( ichushi )

  111. Abematsu Masahiko, Kagawa Tetsushi, Fukuda Shinji, Inoue Toshihiro, Takebayashi Hirohide, Komiya Setsuro, Taga Tetsuya. Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons. J Neurosci Res. 2006.04; 83 (5): 731-743. ( PubMed, DOI )

  112. Takizawa Hitoshi, Kubo-Akashi Chiyomi, Nobuhisa Ikuo, Kwon Sang-Mo, Iseki Masanori, Taga Tetsuya, Takatsu Kiyoshi, Takaki Satoshi. Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood. 2006.04; 107 (7): 2968-2975. ( PubMed, DOI )

  113. Inoue Toshihiro, Kagawa Tetsushi, Fukushima Mikiko, Shimizu Takeshi, Yoshinaga Yutaka, Takada Shinji, Tanihara Hidenobu, Taga Tetsuya. Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin. Stem Cells. 2006.01; 24 (1): 95-104. ( PubMed, DOI )

  114. Yanagisawa Makoto, Taga Tetsuya, Nakamura Kazuo, Ariga Toshio, Yu Robert K. Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells. J Neurochem. 2005.12; 95 (5): 1311-1320. ( PubMed, DOI )

  115. Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T, Yoshizaki K. Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression. Genes to cells : devoted to molecular & cellular mechanisms. 2005.11; 10 (11): 1051-63. ( PubMed, DOI )

  116. Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya. Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture. Neurosci Res. 2005.10; 53 (2): 176-182. ( PubMed, DOI )

  117. Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya. 凝集培養による海馬星状膠細胞の神経細胞系統への運命切り換え(Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture) Neuroscience Research. 2005.10; 53 (2): 176-182. ( ichushi )

  118. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya. Glycosphingolipid synthesis inhibitor represses cytokine-induced activation of the Ras-MAPK pathway in embryonic neural precursor cells. J Biochem. 2005.09; 138 (3): 285-291. ( PubMed, DOI )

  119. Mawatari Yuki, Fukushima Mikiko, Inoue Toshihiro, Setoguchi Takao, Taga Tetsuya, Tanihara Hidenobu. Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas. Brain Res. 2005.09; 1055 (1-2): 7-14. ( PubMed, DOI )

  120. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya. Glycosphingolipid合成阻害剤は胚性神経前駆細胞においてRas-MAPK経路のサイトカイン誘導活性化を抑制する(Glycosphingolipid Synthesis Inhibitor Represses Cytokine-Induced Activation of the Ras-MAPK Pathway in Embryonic Neural Precursor Cells) The Journal of Biochemistry. 2005.09; 138 (3): 285-291. ( ichushi )

  121. 鹿川 哲史, 吉永 豊, 清水 健史, 井上 俊洋, 田賀 哲也. Wnt-3aは神経幹細胞の増殖と海馬発達に際しての神経細胞分化を共に促進する(Wnt-3a promotes both neural progenitor proliferation and neuronal differentiation during hippocampal development) 神経化学. 2005.08; 44 (2-3): 184. ( ichushi )

  122. 波平 昌一, 神山 淳, 田賀 哲也, 中島 欽一. 神経幹細胞の発生・維持の分子機構　星状細胞特異的遺伝子プロモーターにおける脱メチル化の促進がNotchシグナル伝達によりもたらされる(Accelerated demethylation in an astrocyte specific gene promoter mediated by Notch-signaling) 神経化学. 2005.08; 44 (2-3): 169. ( ichushi )

  123. 清水 健史, 鹿川 哲史, 井上 俊洋, 吉永 豊, 田賀 哲也. 繊維芽細胞増殖因子2はグリコーゲン合成酵素キナーゼ3βを不活性化することによって未分化状体の神経幹細胞を維持し増殖を促進する(Fibroblast growth factor 2 maintains neural stem cells in an undifferentiated state and promotes their proliferation via the glycogen synthase kinase 3β inactivation) 神経化学. 2005.08; 44 (2-3): 224. ( ichushi )

  124. Namihira Masakazu, Aonuma Makoto, Setoguchi Hiroki, Kohyama Jun, Taga Tetsuya, Nakashima Kinichi. Notch誘発DNA脱メチル化は神経幹細胞の運命決定に関与する(Notch-induced DNA demethylation involved in fate determination of neural stem cells) Neuroscience Research. 2005.07; 52 (Suppl.): S67. ( ichushi )

  125. Taga Tetsuya, Kagawa Tetsushi, Fukuda Shinji, Shimizu Takeshi, Inoue Toshihiro. サイトカインシグナルは神経発達における細胞運命決定に関与する(Cytokine signals involved in cell fate determination during neural development) Neuroscience Research. 2005.07; 52 (Suppl.): S38. ( ichushi )

  126. Taga Tetsuya, Fukuda Shinji. Role of IL-6 in the neural stem cell differentiation. Clin Rev Allergy Immunol. 2005.06; 28 (3): 249-256. ( PubMed, DOI )

  127. Shimozaki Koji, Namihira Masakazu, Nakashima Kinichi, Taga Tetsuya. Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells. J Neurochem. 2005.04; 93 (2): 432-439. ( PubMed, DOI )

  128. Fukuda Shinji, Taga Tetsuya. Cell fate determination regulated by a transcriptional signal network in the developing mouse brain. Anat Sci Int. 2005.03; 80 (1): 12-18. ( PubMed, DOI )

  129. Fukuda Shinji, Taga Tetsuya. 発達期マウスの脳における転写シグナル系によって制御される細胞発生運命の決定(Cell fate determination regulated by a transcriptional signal network in the developing mouse brain) Anatomical Science International. 2005.03; 80 (1): 12-18. ( ichushi )

  130. Fukuda Shinji, Taga Tetsuya. 中枢神経系の発達および再生中の神経幹細胞の制御(Regulation of neural stem cells during development and regeneration of the central nervous system) 炎症・再生. 2005.01; 25 (1): 18-25. ( ichushi )

  131. Okita Keisuke, Kiyonari Hiroshi, Nobuhisa Ikuo, Kimura Naoki, Aizawa Shinichi, Taga Tetsuya. Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development. Genes Cells. 2004.11; 9 (11): 1083-1091. ( PubMed, DOI )

  132. Setoguchi Takao, Nakashima Kinichi, Takizawa Takumi, Yanagisawa Makoto, Ochiai Wataru, Okabe Masaru, Yone Kazunori, Komiya Setsuro, Taga Tetsuya. Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Exp Neurol. 2004.09; 189 (1): 33-44. ( PubMed, DOI )

  133. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya. Roles of lipid rafts in integrin-dependent adhesion and gp130 signalling pathway in mouse embryonic neural precursor cells. Genes Cells. 2004.09; 9 (9): 801-809. ( PubMed, DOI )

  134. Namihira Masakazu, Nakashima Kinichi, Taga Tetsuya. Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter. FEBS Lett. 2004.08; 572 (1-3): 184-188. ( PubMed, DOI )

  135. あべ松 昌彦, 鹿川 哲史, 福田 信治, 井上 俊洋, 田賀 哲也. bFGFによる大脳皮質神経上皮細胞から大脳基底核原基神経上皮細胞への運命転換(Ventralizing effect of bFGF on cortical neuroepithelial cells) 神経化学. 2004.08; 43 (2-3): 397. ( ichushi )

  136. 清水 健史, 鹿川 哲史, 田賀 哲也. FGF2による神経幹細胞分化制御機構の解析(FGF2 signaling regulates proliferation and maintenance of multipotentiality of neural stem cells via the glycogen synthase kinase3β pathway) 神経化学. 2004.08; 43 (2-3): 487. ( ichushi )

  137. 鹿川 哲史, 荒木 喜美, 田賀 哲也. EmxとDlx発現細胞の細胞系譜解析(In utero fate mapping of Emx- and Dlx-expressing cells in the mouse forebrain) 神経化学. 2004.08; 43 (2-3): 483. ( ichushi )

  138. 波平 昌一, 中島 欽一, 田賀 哲也. エピジェネティクス制御による中枢神経幹細胞のアストロサイト分化制御機構(Developmental stage dependent regulation of epigenetic modification of a premature astrocytic gene promoter) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  139. 中島 欽一, Hsieh Jenny, 桑原 知子, 田賀 哲也, Gage Fred. ヒストン脱アセチル化阻害剤による神経幹細胞のニューロン分化誘導(HDAC inhibitor-mediated neuronal differentiation of adult neural progenitors) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  140. 落合 和, 滝沢 琢己, 中島 欽一, 田賀 哲也. 胎生期脳におけるAINTの役割(Role of AINT in the developing brain) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  141. Setoguchi T, Taga T, Kondo T. Cancer stem cells persist in many cancer cell lines. Cell cycle (Georgetown, Tex.). 2004.04; 3 (4): 414-5. ( PubMed, DOI )

  142. Nobuhisa Ikuo, Kato Reiko, Inoue Hirofumi, Takizawa Makiko, Okita Keisuke, Yoshimura Akihiko, Taga Tetsuya. Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. J Exp Med. 2004.03; 199 (5): 737-742. ( PubMed, DOI )

  143. Fukuda S, Kondo T, Takebayashi H, Taga T. Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway. Cell Death Differ. 2004.02; 11 (2): 196-202. ( PubMed, DOI )

  144. Kondo T, Setoguchi T, Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA. 2004.01; 101 (3): 781-786. ( PubMed, DOI )

  145. Inoue Hirofumi, Nobuhisa Ikuo, Okita Keisuke, Takizawa Makiko, Pebusque Marie Josephe, Taga Tetsuya. Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Biochem Biophys Res Commun. 2004.01; 313 (1): 125-128. ( PubMed )

  146. Nobuhisa Ikuo, Takizawa Makiko, Takaki Satoshi, Inoue Hirofumi, Okita Keisuke, Ueno Masaya, Takatsu Kiyoshi, Taga Tetsuya. Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol Cell Biol. 2003.12; 23 (23): 8486-8494. ( PubMed )

  147. Kwon Sangmo, Takizawa Hitoshi, Nobuhisa Ikuo, Taga Tetsuya, Takatsu Kiyoshi, Takaki Satoshi. Lnkアダプター蛋白はVav2/Rac/Pak経路の活性化を介してサイトカイン受容体媒介性アクチン再構成を制御する(Lnk adaptor protein regulates cytokine receptor-mediated actin reorganization by activating Vav2/Rac/PAK pathways) 日本免疫学会総会・学術集会記録. 2003.11; 33 259. ( ichushi )

  148. Takizawa Takumi, Ochiai Wataru, Nakashima Kinichi, Taga Tetsuya. Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res. 2003.10; 31 (19): 5723-5731. ( PubMed )

  149. 鹿川 哲史, 井上 俊洋, 荒木 喜美, 中平 英子, 池中 一裕, 田賀 哲也. 子宮内エレクトロポレーション法を応用した神経系細胞系譜の解析(A new strategy for brain cell fate mapping by in utero DNA electroporationA new strategy for brain cell fate mapping by in utero DNA electroporation) 神経化学. 2003.08; 42 (2-3): 339. ( ichushi )

  150. Fukuda Shinji, Takizawa Takumi, Namihira Masakazu, Kondo Toru, Nakashima Kinichi, Taga Tetsuya. 細胞分化の分子的基礎　転写ネットワークの交差制御相互作用により支配されている発達中の脳における細胞運命の決定(Molecular basis of cell differentiation: Cell-fate determination in the developing brain governed by cross-regulatory interactions of transcriptional networks) 生化学. 2003.08; 75 (8): 712. ( ichushi )

  151. Taga Tetsuya. マウス脳の発達に関与する転写ネットワークの相互調節作用(Cross-regulatory interactions of transcriptional networks involved in the development of mouse brain) Neuroscience Research. 2003.07; 46 (Suppl.1): S8. ( ichushi )

  152. Shimozaki Koji, Nakashima Kinichi, Niwa Hitoshi, Taga Tetsuya. Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development. 2003.06; 130 (11): 2505-2512. ( PubMed )

  153. Okita Keisuke, Nobuhisa Ikuo, Takizawa Makiko, Ueno Masaya, Kimura Naoki, Taga Tetsuya. Genomic organization and characterization of the mouse ELYS gene. Biochem Biophys Res Commun. 2003.05; 305 (2): 327-332. ( PubMed )

  154. Takizawa Makiko, Nobuhisa Ikuo, Igarashi Katsuhide, Ueno Masaya, Nakashima Kinichi, Kitamura Toshio, Taga Tetsuya. Requirement of gp130 signaling for the AGM hematopoiesis. Exp Hematol. 2003.04; 31 (4): 283-289. ( PubMed )

  155. 權 相模, 高木 智, 信久 幾夫, 田賀 哲也, 高津 聖志. 細胞内アダプター蛋白質Lnkによる細胞骨格系制御とその機能部位(Control of actin cytoskeleton by an intracellular adaptor protein,Lnk and its functional subdomains) 日本癌学会総会記事. 2002.10; 61回 266. ( ichushi )

  156. Hatta Toshihisa, Moriyama Kenji, Nakashima Kinichi, Taga Tetsuya, Otani Hiroki. The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system. J Neurosci. 2002.07; 22 (13): 5516-5524. ( PubMed, DOI )

  157. Nakashima Kinichi, Taga Tetsuya. Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system. Mol Neurobiol. 2002.06; 25 (3): 233-244. ( PubMed, DOI )

  158. Taga Tetsuya, Takizawa Takumi, Nakashima Kinichi. 脳神経系細胞系譜決定とその可塑的変化の分子メカニズム　胎生期中枢神経系の細胞系譜制御に関わる細胞外来性シグナルと細胞内在性プログラム(Cell-external cues and cell-intrinsic programs regulating lineage-determination in the developing brain) 神経化学. 2002.06; 41 (3): 298. ( ichushi )

  159. Uemura Atsumi, Takizawa Takumi, Ochiai Wataru, Yanagisawa Makoto, Nakashima Kinichi, Taga Tetsuya. Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. 2002.04; 18 (1): 1-7. ( PubMed )

  160. Kimura Naoki, Takizawa Makiko, Okita Keisuke, Natori Osamu, Igarashi Katsuhide, Ueno Masaya, Nakashima Kin-ichi, Nobuhisa Ikuo, Taga Tetsuya. Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells. 2002.04; 7 (4): 435-446. ( PubMed )

  161. Taga Tetsuya, Takizawa Takumi, Nakashima Kinichi. 発達中の脳におけるサイトカイン媒介細胞運命の調節(Cytokine-mediated cell-fate regulation in the developing brain) The Japanese Journal of Pharmacology. 2002.03; 88 (Suppl.I): 26P. ( ichushi )

  162. Yanagisawa M, Takizawa T, Ochiai W, Uemura A, Nakashima K, Taga T. Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins. Neurosci Res. 2001.12; 41 (4): 391-396. ( PubMed )

  163. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T. DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell. 2001.12; 1 (6): 749-758. ( PubMed )

  164. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T. Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001.12; 6 (12): 1091-1099. ( PubMed )

  165. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T. Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 GENES TO CELLS. 2001.12; 6 (12): 1091-1099.

  166. Yanagisawa Makoto, Takizawa Takumi, Ochiai Wataru, Uemura Atsumi, Nakashima Kinichi, Taga Tetsuya. 神経上皮細胞の神経発生の骨形態形成蛋白による星細胞発生への変化(Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins) Neuroscience Research. 2001.12; 41 (4): 391-396. ( ichushi )

  167. Fujita Yoshihiko, Ito Hiroe, Iino Ryota, Taga Tetsuya, Kusumi Akihiro. インターロイキン6刺激後のGP130シグナル複合体とアクチンフィラメントの相互作用　単一フルオロフォア動画像(INTERACTION OF GP130 SIGNALING COMPLEX WITH ACTIN FILAMENT AFTER INTERLEUKIN-6 STIMULATION: ANALYSIS BY SINGLE FLUOROPHORE DYNAMIC IMAGING) Cell Structure and Function. 2001.10; 26 (5): 451. ( ichushi )

  168. Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T. Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun. 2001.09; 287 (2): 501-506. ( PubMed, DOI )

  169. 田賀 哲也, 滝沢 琢己, 柳澤 亮, 中島 欽一. サイトカインシグナルによる中枢神経系前駆細胞の系譜制御 神経化学. 2001.09; 40 (2-3): 246. ( ichushi )

  170. Choi MW, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S. Ligand recognition by the vitamin D receptor BIOORGANIC & MEDICINAL CHEMISTRY. 2001.07; 9 (7): 1721-1730.

  171. Choi M, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S. Ligand recognition by the vitamin D receptor. Bioorganic & medicinal chemistry. 2001.07; 9 (7): 1721-30. ( PubMed, DOI )

  172. Nichols J, Chambers I, Taga T, Smith A. Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Development. 2001.06; 128 (12): 2333-2339. ( PubMed )

  173. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T. Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Cytokine. 2001.06; 14 (5): 264-271. ( PubMed, DOI )

  174. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T. Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3 CYTOKINE. 2001.06; 14 (5): 264-271.

  175. Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A. 2001.05; 98 (10): 5868-5873. ( PubMed, DOI )

  176. Nakashima K, Takitawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001.05; 98 (10): 5868-5873.

  177. Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T. Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3. Cytokine. 2001.03; 13 (5): 272-279. ( PubMed, DOI )

  178. Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T. Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 CYTOKINE. 2001.03; 13 (5): 272-279.

  179. Matsuo R, Ochiai W, Nakashima K, Taga T. A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody JOURNAL OF IMMUNOLOGICAL METHODS. 2001.01; 247 (1-2): 141-151.

  180. Matsuo R, Ochiai W, Nakashima K, Taga T. A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody. Journal of immunological methods. 2001.01; 247 (1-2): 141-51. ( PubMed, DOI )

  181. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T. Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J Biochem. 2000.12; 128 (6): 923-932. ( PubMed )

  182. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T. Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons JOURNAL OF BIOCHEMISTRY. 2000.12; 128 (6): 923-932.

  183. Kato Hiroaki, Chen Shi, Kiyama Hiroshi, Ikeda Ken, Kimura Naoki, Nakashima Kinichi, Taga Tetsuya. ニューロン発生時及び再生時に顕著に発現する,WDリピートを持つ新規遺伝子の同定 The Journal of Biochemistry. 2000.12; 128 (6): 923-932. ( ichushi )

  184. Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A. Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem Biophys Res Commun. 2000.10; 277 (1): 152-158. ( PubMed, DOI )

  185. Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A. Cell density-dependent regulation of hepatic development by a gp 130-independent pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000.10; 277 (1): 152-158.

  186. Shin HI, Paola D, Bringhurst FR, Taga T, Suda T, Kronenberg H. gp130 is necessary for full PTH-induced osteoclastic differentiation and activation. JOURNAL OF BONE AND MINERAL RESEARCH. 2000.09; 15 S218.

  187. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T. Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1 GENE. 2000.08; 254 (1-2): 29-35.

  188. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 2000.06; 275 (23): 17647-17652. ( PubMed, DOI )

  189. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 JOURNAL OF BIOLOGICAL CHEMISTRY. 2000.06; 275 (23): 17647-17652.

  190. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T. Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. J Neurochem. 2000.04; 74 (4): 1498-1504. ( PubMed )

  191. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T. Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3 JOURNAL OF NEUROCHEMISTRY. 2000.04; 74 (4): 1498-1504.

  192. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono K, Sicinska W, VanHooke J, DeLuca H F, Yamada S. Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain. Proc Natl Acad Sci U S A. 2000.02; 97 (4): 1467-1472. ( PubMed, DOI )

  193. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono K, Sicinska W, VanHooke J, DeLuca HF, Yamada S. Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.02; 97 (4): 1467-1472.

  194. Barasch J, Yang J, Ware CB, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, Oliver JA. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell. 1999.11; 99 (4): 377-386. ( PubMed )

  195. Barasch J, Yang J, Ware CB, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, Oliver JA. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF CELL. 1999.11; 99 (4): 377-386.

  196. Shin HI, Divieti P, Kobayashi T, Chung U, Taga T, Suda T, Bringhurst RF, Kronenberg H. gp130 deficiency results in fetal hypocalcemia with increased blood serum PTH level. JOURNAL OF BONE AND MINERAL RESEARCH. 1999.09; 14 S197.

  197. Nakashima K, Yanagisawa M, Arakawa H, Taga T. Astrocyte differentiation mediated by LIF in cooperation with BMP2 FEBS LETTERS. 1999.08; 457 (1): 43-46.

  198. Nakashima K, Yanagisawa M, Arakawa H, Taga T. Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS letters. 1999.08; 457 (1): 43-6. ( PubMed, DOI )

  199. Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M, Taga T. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci. 1999.07; 19 (13): 5429-5434. ( PubMed )

  200. Kimura N, Ueno M, Nakashima K, Taga T. A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains JOURNAL OF BIOCHEMISTRY. 1999.07; 126 (1): 180-187.

  201. Yanagisawa M, Nakashima K, Taga T. STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M NEUROSCIENCE LETTERS. 1999.07; 269 (3): 169-172.

  202. Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M, Taga T. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation JOURNAL OF NEUROSCIENCE. 1999.07; 19 (13): 5429-5434.

  203. Kimura Naoki, Ueno Masaya, Nakashima Kinich, Taga Tetsuya. 脳領域特異的遺伝子産物Lhx6.1はTandem LIM-domainsを介してLdb1を相互作用する The Journal of Biochemistry. 1999.07; 126 (1): 180-187. ( ichushi )

  204. Kimura N, Ueno M, Nakashima K, Taga T. A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Journal of biochemistry. 1999.07; 126 (1): 180-7. ( PubMed, DOI )

  205. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain DEVELOPMENTAL BRAIN RESEARCH. 1999.06; 115 (2): 183-193.

  206. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Brain research. Developmental brain research. 1999.06; 115 (2): 183-93. ( PubMed, DOI )

  207. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science. 1999.04; 284 (5413): 479-482. ( PubMed )

  208. Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T, Miyajima A. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer EMBO JOURNAL. 1999.04; 18 (8): 2127-2136.

  209. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 SCIENCE. 1999.04; 284 (5413): 479-482.

  210. van der Meijden M, Gage J, Breen EC, Taga T, Kishimoto T, Martinez-Maza O. IL-6 receptor (CD126 ' IL-6R ') expression is increased on monocytes and B lymphocytes in HIV infection CELLULAR IMMUNOLOGY. 1998.12; 190 (2): 156-166.

  211. Dani C, Chambers I, Johnstone S, Robertson M, Ebrahimi B, Saito M, Taga T, Li M, Burdon T, Nichols J, Smith A. Paracrine induction of stem cell renewal by LIF-deficient cells: A new ES cell regulatory pathway DEVELOPMENTAL BIOLOGY. 1998.11; 203 (1): 149-162.

  212. Betz UAK, Bloch W, van den Broek M, Yoshida K, Taga T, Kishimoto T, Addicks K, Rajewsky K, Muller W. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects JOURNAL OF EXPERIMENTAL MEDICINE. 1998.11; 188 (10): 1955-1965.

  213. Nakashima K, Taga T. gp130 and the IL-6 family of cytokines: Signaling mechanisms and thrombopoietic activities SEMINARS IN HEMATOLOGY. 1998.07; 35 (3): 210-221.

  214. Nakashima K, Taga T. gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities. Seminars in hematology. 1998.07; 35 (3): 210-21. ( PubMed )

  215. Wang XJ, Taga T, Yoshida K, Saito M, Kishimoto T, Kikutani H. gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6 BLOOD. 1998.05; 91 (9): 3308-3314.

  216. Nyui N, Tamura K, Mizuno K, Ishigami T, Kihara M, Ochiai H, Kimura K, Umemura S, Ohno S, Taga T, Ishii M. Gp130 is involved in stretch-induced MAP kinase activation in cardiac myocytes BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998.04; 245 (3): 928-932.

  217. Kimura T, Sakabe H, Tanimukai S, Abe T, Urata Y, Yasukawa K, Okano A, Taga T, Sugiyama H, Kishimoto T, Sonoda Y. Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors BLOOD. 1997.12; 90 (12): 4767-4778.

  218. Botchkareya NV, Botchkarev VA, Taga T, Paus R. Ciliary neurotrophic factor, interleukin-6 and their signal transducing receptor component gp130 in murine skin: Expression changes during hair follicle morphogenesis and cycling JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1997.09; 109 (3): 440.

  219. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature. 1997.06; 387 (6636): 924-929. ( PubMed, DOI )

  220. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor NATURE. 1997.06; 387 (6636): 924-929.

  221. Nakashima K, Narazaki M, Taga T. Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130 FEBS LETTERS. 1997.02; 403 (1): 79-82.

  222. Taga T. The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines ANNALS OF MEDICINE. 1997.02; 29 (1): 63-72.

  223. Nakashima K, Narazaki M, Taga T. Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130 FEBS LETTERS. 1997.01; 401 (1): 49-52.

  224. Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 1997; 15 797-819. ( PubMed, DOI )

  225. Taga T. Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines. J Neurochem. 1996.07; 67 (1): 1-10. ( PubMed )

  226. Hirota H, Kiyama H, Kishimoto T, Taga T. Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J Exp Med. 1996.06; 183 (6): 2627-2634. ( PubMed )

  227. Hirota H, Yoshida K, Kishimoto T, Taga T. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci USA. 1995.05; 92 (11): 4862-4866. ( PubMed )

  228. Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA. 1994.03; 91 (6): 2285-2289. ( PubMed )

  229. Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science. 1994.01; 263 (5143): 89-92. ( PubMed )

  230. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell. 1994.01; 76 (2): 253-262. ( PubMed )

  231. Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993.06; 260 (5115): 1808-1810. ( PubMed )

  232. Taga T, Kishimoto T. Cytokine receptors and signal transduction. FASEB J. 1992.12; 6 (15): 3387-3396. ( PubMed )

  233. Taga T, Narazaki M, Yasukawa K, Saito T, Miki D, Hamaguchi M, Davis S, Shoyab M, Yancopoulos GD, Kishimoto T. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA. 1992.11; 89 (22): 10998-11001. ( PubMed )

  234. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science. 1992.10; 258 (5082): 593-597. ( PubMed )

  235. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990.12; 63 (6): 1149-1157. ( PubMed )

  236. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989.08; 58 (3): 573-581. ( PubMed )

  237. Taga T, Hibi M, Hirata Y, Yawata H, Natsuka S, Yasukawa K, Totsuka T, Yamasaki K, Hirano T, Kishimoto T. Interleukin-6 receptor and a unique mechanism of its signal transduction. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2 713-722. ( PubMed )

  238. Yamasaki Katsuhiko, Taga Tetsuya, Hirata Yuuichi. Interleukin 6receptorの分子構造 Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 1988.09; 64 (7): 209-211. ( ichushi )

  239. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988.08; 241 (4867): 825-828. ( PubMed )

  240. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988.03; 332 (6159): 83-85. ( PubMed, DOI )

  241. Taga T, Kawanishi Y, Hardy RR, Hirano T, Kishimoto T. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med. 1987.10; 166 (4): 967-981. ( PubMed )

  242. Hirano T, Taga T, Yasukawa K, Nakajima K, Nakano N, Takatsuki F, Shimizu M, Murashima A, Tsunasawa S, Sakiyama F. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci USA. 1987.01; 84 (1): 228-231. ( PubMed )

  243. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, Kishimoto T. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci USA. 1985.08; 82 (16): 5490-5494. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. Tesuya Taga. Overview of inflammatory diseases involving bone, skin and beyond. 16th World Congress on Inflammation 2024.07.22

  2. Melig Gerel, Nobuhisa Ikuo, Saito Kioka, Tsukahara Ryota, Itabashi Ayumi, Kanai Yoshiakira, Kanai-Azuma Masami, Taga Tetsuya. Rasip1 is a downstream effector of Sox17 that plays a role in maintaining hematopoietic cluster cells in midgestation mouse embryos. The 45th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2024.07.17

  3. Tetsuya Taga, Norihisa Bizen, Kouichi Tabu, Mei Wu, Christian Mangani, Rong Zhang, Mark Bradley. Identification of a niche-mimicking synthetic polymer scaffold for the maintenance of neural stem cells in a culture system without growth factors and serum. The 21st Stem Cell Research Symposium 2024.05.25

  4. Taichi Kashiwagi, Tetstsushi Kagawa, Ikuo Nobuhisa, Akihiko Yoshimura, Tetsuya Taga. NSC fate preference transition from neurogenesis to astrogliogenesis by the FGF signaling negative feed-back regulator Sprouty 4 . The 21st Stem Cell Research Symposium 2024.05.24

  5. Gerel Melig，Ikuo Nobuhisa，Kiyoka Saito，Ryota Tsukahara，Ayumi Itabashi，Yoshiakira Kanai，Masami Kanai-Azuma，Tetsuya Taga. Rasip1 helps maintenance of hematopoietic activities of mouse embryonic intra-aortic hematopoietic clusters.. The 44th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2023.07.12

  6. Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Tetsuya Taga. Rasip1 gene functioning downstream of Sox17 maintains the hematopoietic cluster-forming cells in E10.5 mouse embryos.. The 20th Stem Cell Research Symposium 2023.05.19

  7. Taichi Kashiwagi, Yuuki Takazawa, Tetsushi Kagawa, Tetsuya Taga. Self-maintenance strategies of neural stem/progenitor cells via autocrine VEGF-A under hypoxia in the developing brain.. The 20th Stem Cell Research Symposium 2023.05.19

  8. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Establishment of a high-content polymer array screening system to explore niche mimicries for cancerous cells. The 17th International Symposium of the Institute Network for Biomedical Science International Symposium on Tumor Biology in Kanazawa 2022 2022.10.14 Cancer Research Institute of Kanazawa University, Kanazawa, Japan

  9. Kouichi Tabu, Shinji Kohsaka, Takuichiro Hide, Tetsuya Taga. Synthetic polymer microenvironment array chip based development of new cell phenomics for cancer stratification The 81st Annual Meeting of the Japanese Cancer Association. The 81st Annual Meeting of the Japanese Cancer Association 2022.10.01 Pacifico Yokohama, Yokohama, Japan

  10. Tingting Zhang, Kouichi Tabuk, Yoshitaka Murota, Takuichiro Hide, Shunichiro Ogura, Tetsuya Taga. Exploration of glioma recurrence-related genes upregulated in highly invasive and 5-ALA-PDD escaping cells. The 81st Annual Meeting of the Japanese Cancer Association 2022.09.30 Pacifico Yokohama, Yokohama, Japan

  11. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga. Establishment of a high-content screening system for niche mimicries using polymer-immobilized microwell array plates. The 81st Annual Meeting of the Japanese Cancer Association 2022.09.30 Pacifico Yokohama, Yokohama, Japan

  12. Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. Rasip1-mediated maintenance of Sox17-transduced intra-aortic hematopoietic cluster cells. The 43rd Annual Meeting of the Japanese Society of Inflammation and Regeneration 2022.07.06 Awaji Yumebutai International Conference Center, Awaji, Japan

  13. Tetsuya Taga, Kenji Kabashima. New regulatory mode of innate immunity, the organizers' opening remarks. The 15th World Congress on Inflammation 2022.06.08 Ergife Conference Center, Rome, Italy

  14. Tetsuya Taga, Norihisa Bizen, Kouichi Tabu, Mei Wu, Christian Mangani, Rong Zhang, Mark Bradley. Identification of a niche-mimicking synthetic polymer scaffold that maintains neural stem cells in a growth factor- and serum-free system. The 19 th Stem Cell Research Symposium 2022.05.27 Awaji Yumebutai International Conference Center, Awaji, Japan

  15. Norihisa Bizen, Tetsushi Kagawa, Toshinobu Nakamura, Hirohide Takebayashi, Toru Nakano, Tetsuya Taga. 5-methylcytosine hydroxylase Tet3 endows embryonic neural stem/precursor cells with astrogliogenic competence. The 19th Stem Cell Research Symposium 2022.05.27 Awaji Yumebutai International Conference Center, Awaji, Japan

  16. Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Investigating the function of Rasip1 in HSC-containing IAHCs of midgestation mouse embryos. The 19th Stem Cell Research Symposium 2022.05.27 Awaji Yumebutai International Conference Center, Awaji, Japan

  17. Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. Rasip1 preserves the maintenance of the hematopoietic activity of cluster forming cells in E10.5 mouse embryos. 第44回日本分子生物学会年会 2021.12.01 パシフィッコ横浜

  18. 椨康一, 田賀哲也. Cancer stem cell niche-mimicking polymer-based exploration of the factors responsible for glioma recurrence. The 80th Annual Meeting of the Japanese Cancer Association 2021.10.01

  19. Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Involvement of Rasip1 in the maintenance of hematopoietic ability of intra-aortic hematopoietic cell clusters in midgestation mouse embryos. The 42nd Annual Meeting of the Japanese Society of Inflammation and Regeneration 2021.07.07

  20. Mariko Nagane, Kouichi Tabu, Yoshitaka Murota, Shinji Tanaka, Tetsuya Taga. Niche-mimicking polymer-based characterization of human pancreatic cancer stem cells (pCSCs). The 18th Stem Cell Research Symposium 2021.05.21

  21. Kouichi Tabu, Tetsuya Taga . Polymer-based elucidation of molecular basis underlying cancer stem cell-mediated niche reconstruction and glioma recurrence. The 18th Stem Cell Research Symposium 2021.05.21

  22. Tabu K, Zhang S, Kosaku A, Venkateswaran S, Kohsaka S, Bradley M, Taga T . Synthetic polymer-based stratification of soft tissue sarcomas with different gene alterations and cells of origin. 11th World Biomaterials Congress (WBC Virtual 2020) 2020.12.11

  23. Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. Contribution of Rasip1 to the maintenance of hematopoietic activity of cluster-forming cells in midgestation mouse embryos. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  24. Nagane M, Tabu K, Murota Y, Tanaka S, Taga T. Fabrication of niche-mimicking polymer hydrogels to characterize human pancreatic cancer stem cells. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  25. Kosaku A, Tabu K, Kohsaka S, Taga T . A new stratification method for predicting chemosensitivities of soft tissue sarcomas using synthetic polymer microarray. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01

  26. Tabu K and Taga T. Chemical fabrication of bio-functional polymer-hydrogels that mimic cancer stem cell niche. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01

  27. Nobuhisa I, Saito K, Tsukahara R, Azuma K, Melig G, Itabashi A, Taga T. Involvement of TET1 in the maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.11 Act City Hamamatsu, Hamamatsu, Japan

  28. Tabu K, Wenyu L and Taga T. A self-expanding strategy of glioma stem cells via promoting the development of M1-like tumor-associated macrophages. . The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019.12.04 Fukuoka Convention Center, Fukuoka

  29. Tsukahara Y, Nobuhisa I, Saito K, Kanai Y, Kanai M, and Taga T . The role of GIMAP family in the maintenance of hematopoietic capacity in hematopoietic cell cluster in midgestation mouse dorsal aorta. The 42th Annual Meeting of the Molecular Biology Society of Japan 2019.12.02 Fukuoka Convention Center, Fukuoka, Japan

  30. Aimaitijiang A, Tabu K and Taga T. Glioma stem cells modulate erythropoiesis in mouse bone marrow. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  31. Tabu K and Taga T. Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  32. Aimaitijiang A, Tabu K and Taga. Glioma stem cells modulate erythropoiesis in mouse bone marrow. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  33. Tabu K and Taga T. Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.28 Kyoto, Japan

  34. Taga T and Tabu K. Exploration of molecular mechanisms regulating cancer stem cells and their niche. TMDU International Summer Program (ISP) 2019 2019.07.09 TMDU, Bunkyo-ku, Japan

  35. Hagihara H, Shoji H, Kohno T, Hayata A, Tamada K, Hori K, Tatsukawa T, Shibutani M, Wakatsuki S, Hagino Y, Kasahara T, Numakawa T, Ohtabi H, Nobuhisa I, Hoshiba Y, Nakamura H, Katori S, Yamanishi K, Takamiya Y, Tanaka M, Yalcin I, Matsushita M, Hattori M, Hashimoto H, Takumi T, Hoshino M, Tabuchi K, Yamakawa K, Hatada I, Ikeda K, Kato T, Kunugi H, Toyoda A, Taga T, Hayashi-Takagi A, Goshima Y, Iwasato T, Okabe S, Meltzer HY, Miyakawa T. Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes. The 21st Annual Meeting of the International Behavioural and Neural Genetics Society 2019.05.10 the University of Edinburgh, Edinburgh, Scotland, UK

  36. Taga T and Tabu K. Development of Treatment Strategies Targeting Cancer Stem Cells. The 3rd Meeting of International Society of Precision Cancer Medicine 2019.03.14 Seoul, Korea

  37. Nobuhisa I, Saito K, Azuma K, Iizauka N, and Taga T. The contribution of TET1 to the maintenance of the hematopoietic capacity in hematopoietic stem cell-containing clusters in the dorsal aorta in midgestation mouse embryo. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.10 Fukuoka International Congress Center, Fukuoka, Japan

  38. Tabu K and Taga T. A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance. The 77th Annual Meeting of the Japanese Cancer Association 2018.09.29 大阪国際会議場、大阪

  39. Tabu K and Taga T. Identification of a subpopulation of glioma cells with a potential for tumor niche development involving myeloid cells. The 16th Stem Cell Research Symposium 2018.06.02 Centennial Hall, Kyushu University, Fukuoka, Japan

  40. Nobuhisa I, Saito K, and Taga T. Expression of TET family members in hematopoietic stem cell-containing clusters of the dorsal aorta in midgestation mouse embryo. The 16th Stem Cell Research Symposium 2018.06.02 Centennial Hall, Kyushu University School of Medicine

  41. Tabu K and Taga T. Abilities of cancer stem cells to organize the self-advantageous microenvironment niche. TMU-TMDU Joint Symposium 2018 2018.03.24 Tokyo Medical and Dental University, Tokyo, Japan

  42. Nobuhisa I, Takahashi S, Saito K, and Taga T. Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai International Center, Sendai, Japan

  43. Saito K, Nobuhisa I, and Taga T. The mechanism of maintaining the undifferentiated state of hematopoietic stem cell by Sox17 and TET family members. The 40th Annual Meeting of the Molecular Biology Society of Japan 2017.12.07 Kobe International Conferance Center, Kobe, Japan

  44. Murota Y, Wenqing GY, Tabu K, and Taga T. Establishment of glioma mouse model by transducing oncogenic H-RasV12 gene into the p53 deficient astrocytes. The 76th Annual Meeting of the Japanese Cancer Association 2017.09.30 Pacifico Yokohama, Yokohama, Japan

  45. Tabu K, Wang W, Murota Y and Taga T. Self-expanding strategies of glioma stem cells that involves macrophages to adapt to iron-deprivation stress. The 76th Annual Meeting of the Japanese Cancer Association 2017.09.28 Pacifico Yokohama, Yokohama, Japan

  46. Taga T, Takayanagi H, Takeuchi T. Comprehensive perspectives of systemic and organ specific inflammatory responses (Opening Remarks by T. Taga).. 13th World Congress on Inflammation: Symposium on "Comprehensive perspectives of systemic and organ specific inflammatory responses" (organized by T. Taga, H. Takayanagi, and T. Takeuchi). 2017.07.08 Hilton London Metropole, London, United Kingdom

  47. Murota Y, Schmidt S, Tabu K, Ito H, Tanaka S, Bradley M and Taga T. Screening for human pancreatic cancer stem cell niche mimicry by using synthetic polymer microarrays. The 15th Stem Cell Research Symposium 2017.05.27 Tokyo University, Tokyo, Japan

  48. Tabu K and Taga T. Self-maintenance strategies of glioma stem cells (GSCs) involving GSC-induced protumoral macrophages. 11th International Symposium of The Institute Network 2017.01.27 Tokushima University, Tokushima, Japan

  49. Kagawa T, Yamaguchi Y, Sudo G, Kokubu Y, Hattori S, Takao K, Miyakawa T, Inazawa J, and Taga T. Astroglial development is regulated by DNA and histone methylation: from molecular basis to behavioral abnormalities in gene-manipulated mice. Cold Spring Harbor Asia meeting on Novel Insights into Glia Function & Dysfunction 2016.12.06 Suzhou Industrial Park Conference Center, Suzhou, China

  50. Saito K, Nobuhisa I, Anani M, Harada K, Takahashi S, Lickert H, Kanai M, Kanai Y, and Taga T. Mechanism of maintaining hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis. The 39th Annual Meeting of the Molecular Biology Society of Japan 2016.12.01 Pacifico Yokohama, Yokohama, Japan

  51. Takahashi S, Nobuhisa I, Saito K, and Taga T. Involvement of transcription factor Sox17-mediated expression of adhesion molecules in hematopoietic cell cluster formation in midgestation mouse dorsal aorta. The 39th Annual Meeting of the Molecular Biology Society of Japan 2016.12.01 Pacifico Yokohama, Yokohama, Japan

  52. Tabu K, Wang W, Murota Y and Taga T. Adaptive response of C6 glioma stem cells to iron deprivation through macrophage induction. The 75th Annual Meeting of the Japanese Cancer Association 2016.10.06 Pacifico Yokohama, Yokohama, Japan

  53. Wang W, Tabu K, Hagiya Y, Murota Y, Ogura S and Taga T. Enhancement of 5-aminolevulinic acid-based fluorescence detection of glioma stem cells by chelating iron. The 75th Annual Meeting of the Japanese Cancer Association 2016.10.06 Pacifico Yokohama, Yokohama, Japan

  54. Saito K, Nobuhisa I, Anani M, Harada K, Takahashi S, and Taga T. Mechanism of maintaining hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis. hematopoiesis through the Sox17-Notch1-Hes1 axis. The 14th Stem Cell Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Hyogo, Japan

  55. Wang W, Tabu K, Sugiyama Y, Hagiya Y, Ogura S and Taga T. Resistance of glioma stem cells to 5-aminolevulinic acid (ALA)-based detection due to enhanced metabolic conversion of protoporphyrin IX. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  56. Murota Y, Tabu K and Taga T. C6 glioma stem cell-derived extracellular vesicles promote the development of macrophages. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  57. Tabu K, Kokubu Y, Muramatsu N, Nomoto S, Wang W and Tetsuya Taga. Adaptive response of rat C6 glioma stem cells to iron deprivation by which the development of tumor infiltrating macrophages is induced. The 14th Stem Cell Research Symposium 2016.05.20 Awaji Yumebutai International Conference Center, Awaji, Japan

  58. Sudo G. Analysis of pathogenic mechanisms of neurodevelopmental disorder-like phenotype exhibited by histone demethylase Gasc1 hypomorphic mutant mice. The 9th Annual Meeting for Japanese Developmental Neuroscientists 2016.03.18 Tokyo Medical and Dental University, Tokyo

  59. Tabu K, Muramatsu N, and Taga T. Synthetic polymer-based approach revealed an adaptive capacity of glioma stem cells by inducing tumor-infiltrating and iron-accumulating macrophages. The 38th Annual Meeting of the Molecular Biology Society of Japan 2015.12.01

  60. Saito K, Nobuhisa I, Anani M, Harada K, Takahashi S, and Taga T. Maintenance of hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region as a site of definitive hematopoiesis through the Sox17-Notch1-Hes1 axis. The 38th Annual Meeting of the Molecular Biology Society of Japan 2015.12.01 Kobe International Conferance Center, Kobe, Japan

  61. Nobuhisa I, Saito S, Takahashi S, Harada K, Anani M, and Taga T. Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region through Notch signaling. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.19 Sapporo Convention Center, Sapporo, Japan

  62. Wang W, Tabu K, KokubuY, Hagiya Y, Ogura S, and Taga T. Splenic abnormal erythropoiesis in C6 glioma-bearing mice: an implication for their environment of cancer stem cells. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.08

  63. Saito K, Nobuhisa I, Anani M, Harada K, Takahashi S, and Taga T. Maintenance of hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis. International Society for Experimental Hematology 44th Annual Scientific Meeting 2015.09.18 The Kyoto International Conference, Kyoto, Japan

  64. Ikuo Nobuhisa, Mitsujiro Osawa, Mami Uemura, Kaho Harada, Maha Anani, Kiyoka Saito, Haruna Takagi, Satomi, Takahashi, Masami Kanai-Azuma, Yoshiakira Kanai, Atsushi Iwama, Tetsuya Taga. Sox17 is critical for the maintenance of stem cell phenotype of intra-aortic hematopoietic clusters of cells in the aorta-gonad-mesonephros region. International Society for Experimental Hematology 44th Annual Scientific Meeting 2015.09.17 The Kyoto International Conference, Kyoto, Japan

  65. Ikuo Nobuhisa and Tetsuya Taga. Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region. The 10th International Symposium of the Institute Network 2015.07.23

  66. Kiyoka Saito, Ikuo Nobuhisa, Maha Anani, Kaho Harada, Satomi Takahashi, Tetsuya Taga. Maintenance of intra-aortic hematopoietic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis. The 13th Stem Cell Symposium 2015.05.29 Ito International Research Center, Tokyo, Japan

  67. Taga T and Tabu K. Characterization of C6 glioma cancer stem cells and their niche. Seoul National University, Cancer Research Institute (SNU CRI) Annual Symposium 2015 ‘Innovative Approaches to Explore Novel Druggable Targets' 2015.04.02 Hwasun, Korea

  68. Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, Taga T . Sustained expression of Sox17 in AGM-derived hematopoietic stem/progenitor cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors. 第43回日本免疫学会学術集会 2014.12.11 京都国際会館

  69. Nobuhisa I, Anani M, Osawa M, Iwama A, Harada K, Saito K, Taga T . Sustained expression of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors. 第37回日本分子生物学会年会 2014.11.26 パシフィッコ横浜

  70. Taga T. Characteristics of glioma cancer stem cell niche revealed by synthetic polymers. 14th Japanese-German Cancer Research Workshop 2014.11.14 Berlin

  71. Taga T. Niche signals regulating neural stem cells and glioma stem cells revealed by synthetic polymers. Collaborative Meeting between High-Throughput Chemical Biology, School of Chemistry, University of Edinburgh and Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University 2014.11.02 Edinburgh

  72. Wang W, Tabu K, Sugiyama Y, Hagiya Y, Ogura S, and Taga T. Roles of cancer-derived heme in erythropoiesis: implications for erythroid niche for cancer stem cells. The 73rd Annual Meeting of the Japanese Cancer Association 2014.09.25 Yokohama

  73. Kokubu Y, Tabu K, Wang W, Baghdadi M, Jinushi M, and Taga T. C6 glioma stem cell-derived GM-CSF induces　CD11chighCD204(+) protumoral macrophages. The 73rd Annual Meeting of the Japanese Cancer Association 2014.09.25 Yokohama

  74. Tabu K, Kokubu Y, Taga T. Autoschizic cancer cell death and its implications to cancer stem cell niche. The 73rd Annual Meeting of the Japanese Cancer Association 2014.09.25 Yokohama

  75. Taga T. Understanding of glioma stem cell niche and application of synthetic polymers. The 32nd Japan Human Cell Society Meeting 2014.08.30 Tokyo

  76. Taga T. Niche signals regulating neural stem cells and glioma stem cells. The 10th Annual Meeting of Korean Society for Stem Cell Research 2014.08.28 Soul

  77. Taga T and Tabu K. Understanding of C6 glioma cancer stem cell niche with the use of synthetic polymers. The 12th Stem Cell Research Symposium 2014.05.31 Fukuoka

  78. Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, and Taga T. Sox17-transduction imparts fetal hematopoietic cells with the myeloid-restricted differentiation potential. 第12回幹細胞シンポジウム 2014.05.30 福岡市

  79. Wang W, Tabu T, Sugiyama Y, Hagiya Y, Ogura S, and Taga T. C6 glioma SP and MP cells are different metabolism on the ALA-PplX-heme pathway: an implication for self-creating cancer stem cell niche. The 12th Stem Cell Research Symposium 2014.05.30 Fukuoka

  80. Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, and Taga T. Dual roles of cyclin D1 in self-renewal of neural stem cells: promotion of cell proliferation and inhibition of glial differentiation. The 12th Stem Cell Research Symposium 2014.05.30 Fukuoka

  81. Kokubu Y, Tabu K, Muramatsu N, Murota Y, Kimura R, and Taga T. Heterogeneity within CD204(+) tumor-associated macrophages induced by C6 glioma stem cells. The 12th Stem Cell Research Symposium 2014.05.30 Fukuoka

  82. Taga T and Tabu K. Characterization of C6 glioma cancer stem cell niche by using synthetic polymers for the development of therapeutic strategies. 2014 Seoul National University Cancer Research Institute Cancer Symposium 2014.04.16 Mokpo, Korea

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Awards & Honors 【 display / non-display 】

  • ISI Citation Laureate Award "Authoring multiple high impact papers"，2000

  • The Japanese Society of Immunology Award，1999

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Others 【 display / non-display 】

  • The origins of blood: researchers identify a gene critical to blood production，2023.09

  • Filling a niche: Neural stem cells help maintain their microenvironment，2023.03

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Campus class subject 【 display / non-display 】

  • Initial Research Training, Graduate School of Medical and Dental Sciences

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