Personnel Information

写真a

TAGA Tetsuya


Job title

Professor

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Laboratory Phone number

+81-3-5803-5814

Laboratory Fax number

+81-3-5803-5814

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

Stem Cell Biology, Neural Stem Cell, Hematopoietic Stem Cell, Cancer Stem Cell

Profile

Professor Tetsuya Taga's research at the Department of Stem Cell Regulation has been conducted to elucidate the mechanisms by which stem cells are regulated. The major focus has been on neural stem cells, hematopoietic stem cells, and cancer stem cells. The study is aimed to understand development, maintenance, and regeneration of the central nervous system and the hematopoietic system, and to obtain a clue to tackle the problem of cancer recurrence. Particular attention is given to cell-external cues (such as cytokines) and cell-intrinsic programs (including chromatin modification), taking cross-interactions of transcriptional regulatory signals into consideration.

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Science, Biology: Plant Physiology, 1982, Graduated

Graduate School 【 display / non-display

  • Osaka University, Graduate School, Division of Medicine, Pathology: Immunology, Doctor's Course, 1988, Completed

Degree 【 display / non-display

  • Ph.D., Osaka University

Campus Career 【 display / non-display

  • 2008.12
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Professor
  • 2013.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Vice President
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Molecular Cell Biology, Professor

External Career 【 display / non-display

  • 1987.04
    -
    1989.03
    Japan Society for the Promotion of Science, Institute for Molecular and Cellular Biology, Osaka University, Research Fellow
  • 1989.04
    -
    1989.10
    Osaka University, Institute for Molecular and Cellular Biology, Research Fellow
  • 1989.11
    -
    1996.06
    Osaka University, Institute for Molecular and Cellular Biology, Assistant Professor
  • 1996.07
    -
    1996.08
    Osaka University, Institute for Molecular and Cellular Biology, Accociate Professor
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University, Medical Research Institute,

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Academic Society Affiliations 【 display / non-display

  • The Japanese Society of Inflammation and Regeneration

  • Japanese Society for Immunology

  • The Japanese Society for Regenerative Medicine

  • The Japanese Cancer Association

  • The Molecular Biology Society of Japan

Academic Activity 【 display / non-display

  • 2013.04
    -
    2023.07
    The Japanese Society of Inflammation and Regeneration Director
  • 2002.07
    -
    2023.07
    The Japanese Society of Inflammation and Regeneration Councillor
  • 1995.01
    -
    2022.12
    Japanese Society for Immunology Council Member
  • 2001.05
    -
    2018.10
    The Japanese Society for Regenerative Medicine A delegate
  • 2001.10
    -
    2006.03
    Director, Institute of Molecular Embryology and Genetics, Kumamoto University

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Research Areas 【 display / non-display

  • Stem Cell Biology

 

Research Theme 【 display / non-display

  • Molecular Regulation of Stem Cells

Published Papers & Misc 【 display / non-display

  • Tabu Kouichi, Taga Tetsuya. Chemical fabrication of bio-functional polymer-hydrogels that mimic cancer stem cell niche CANCER SCIENCE. 2021.02; 112 378.

  • Kosaku Akina, Tabu Kouichi, Kohsaka Shinji, Taga Tetsuya. A new stratification method for predicting chemosensitivities of soft tissue sarcomas using synthetic polymer microarray CANCER SCIENCE. 2021.02; 112 881.

  • Suzuki Izumi, Yoshida Sachiko, Tabu Kouichi, Kusunoki Soshi, Matsumura Yumiko, Izumi Hiroto, Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Sonoda Kenzo, Kohno Kimitoshi, Taga Tetsuya, Itakura Atsuo, Takeda Satoru, Kato Kiyoko. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer SCIENTIFIC REPORTS. 2021.02; 11 (1): ( DOI )

  • Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Takeda S, Kato K. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Sci. Rep.. 2021.01; in press.

  • Anani M, Nobuhisa I, Taga T. Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway. Journal of Cancer Prevention. 2020.12; 25 (4): 204-212. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Tabu K, Zhang S, Kosaku A, Venkateswaran S, Kohsaka S, Bradley M, Taga T . Synthetic polymer-based stratification of soft tissue sarcomas with different gene alterations and cells of origin. 11th World Biomaterials Congress (WBC Virtual 2020) 2020.12.11

  • Itabashi A, Nobuhisa I, Yokoi Y, Kiyoka S, Tsukahara R, Melig G, Taga T.. Ability to form the cell cluster of Sox17-transduced HSPCs weakens along with the development. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  • Nagane M, Tabu K, Murota Y, Tanaka S, Taga T. Fabrication of niche-mimicking polymer hydrogels to characterize human pancreatic cancer stem cells. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  • Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. Contribution of Rasip1 to the maintenance of hematopoietic activity of cluster-forming cells in midgestation mouse embryos. The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020.12.02

  • Kosaku A, Tabu K, Kohsaka S, Taga T . A new stratification method for predicting chemosensitivities of soft tissue sarcomas using synthetic polymer microarray. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01

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Awards & Honors 【 display / non-display

  • ISI Citation Laureate Award "Authoring multiple high impact papers",2000

  • The Japanese Society of Immunology Award,1999

 

Campus class subject 【 display / non-display

  • Initial Research Training, Graduate School of Medical and Dental Sciences