Personnel Information

写真a

TAGA Tetsuya


Job title

Professor

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Laboratory Phone number

+81-3-5803-5814

Laboratory Fax number

+81-3-5803-5814

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

Stem Cell Biology, Neural Stem Cell, Hematopoietic Stem Cell, Cancer Stem Cell

Profile

Professor Tetsuya Taga's research at the Department of Stem Cell Regulation has been conducted to elucidate the mechanisms by which stem cells are regulated. The major focus has been on neural stem cells, hematopoietic stem cells, and cancer stem cells. The study is aimed to understand development, maintenance, and regeneration of the central nervous system and the hematopoietic system, and to obtain a clue to tackle the problem of cancer recurrence. Particular attention is given to cell-external cues (such as cytokines) and cell-intrinsic programs (including chromatin modification), taking cross-interactions of transcriptional regulatory signals into consideration.

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Science, Biology: Plant Physiology, 1982, Graduated

Graduate School 【 display / non-display

  • Osaka University, Graduate School, Division of Medicine, Pathology: Immunology, Doctor's Course, 1988, Completed

Degree 【 display / non-display

  • Ph.D., Osaka University

Campus Career 【 display / non-display

  • 2008.12
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Professor
  • 2008.12
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Stem Cell Regulation, Professor
  • 2013.04
    -
    Now
    Tokyo Medical and Dental University, Board Member, Vice President

External Career 【 display / non-display

  • 1987.04
    -
    1989.03
    Japan Society for the Promotion of Science, Institute for Molecular and Cellular Biology, Osaka University, Research Fellow
  • 1989.04
    -
    1989.10
    Osaka University, Institute for Molecular and Cellular Biology, Research Fellow
  • 1989.11
    -
    1996.06
    Osaka University, Institute for Molecular and Cellular Biology, Assistant Professor
  • 1996.07
    -
    1996.08
    Osaka University, Institute for Molecular and Cellular Biology, Accociate Professor
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University, Medical Research Institute,

display all >>

Academic Society Affiliations 【 display / non-display

  • The Japanese Society of Inflammation and Regeneration

  • The Japanese Society for Regenerative Medicine

  • Japanese Society for Immunology

  • The Japanese Cancer Association

  • The Molecular Biology Society of Japan

Academic Activity 【 display / non-display

  • 2002.07
    -
    2019.03
    The Japanese Society of Inflammation and Regeneration Councillor
  • 2013.04
    -
    2019.03
    The Japanese Society of Inflammation and Regeneration Standing director
  • 2001.05
    -
    2018.10
    The Japanese Society for Regenerative Medicine A delegate
  • 1995.01
    -
    2018.12
    Japanese Society for Immunology Council Member
  • 2001.10
    -
    2006.03
    Director, Institute of Molecular Embryology and Genetics, Kumamoto University

display all >>

Research Areas 【 display / non-display

  • Stem Cell Biology

 

Research Theme 【 display / non-display

  • Molecular Regulation of Stem Cells

Published Papers & Misc 【 display / non-display

  • Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, and Taga T . Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis Exp Cell Res. 2018.04; 365 (1): 145-155. ( DOI )

  • Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa.. Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes. Mol Biol Cell. 2018.01; 29 209-219. ( DOI )

  • Harada K, Nobuhisa I, Anani M, Saito K, Taga T. Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( DOI )

  • Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI, and Taga T. Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. Sci Rep. 2017.02; 7 42070. ( PubMed, DOI )

  • Murota Y, Tabu K, and Taga T. Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes. BMC Cancer. 2016.11; 16 847. ( PubMed, DOI )

display all >>

Conference Activities & Talks 【 display / non-display

  • Taga T. Pathogenesis in the mouse model of psychomotor disorder caused by histone demethylase Gasc1 gene mutation. The 40th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2019.07.16 Kobe International Conferance Center, Kobe, Japan

  • Taga T and Tabu K. Exploration of molecular mechanisms regulating cancer stem cells and their niche. TMDU International Summer Program (ISP) 2019 2019.07.09 TMDU, Bunkyo-ku, Japan

  • Taga T and Tabu K. Development of Treatment Strategies Targeting Cancer Stem Cells. The 3rd Meeting of International Society of Precision Cancer Medicine 2019.03.14 Seoul, Korea

  • Nobuhisa I, Saito K, Azuma K, Iizauka N, and Taga T. The contribution of TET1 to the maintenance of the hematopoietic capacity in hematopoietic stem cell-containing clusters in the dorsal aorta in midgestation mouse embryo. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.10 Fukuoka International Congress Center, Fukuoka, Japan

  • Iizuka N, Nobuhisa I Saito K, Azuma K, and Taga T. Involvement of an NF-κB signal pathway in the maintenance of an undifferentiated state of hematopoietic stem cell-containing clusters in the midgestation mouse dorsal aorta. The 41th Annual Meeting of the Molecular Biology Society of Japan 2018.11.29 Pacifico Yokohama, Yokohama, Japan

display all >>

Awards & Honors 【 display / non-display

  • ISI Citation Laureate Award "Authoring multiple high impact papers",2000

  • The Japanese Society of Immunology Award,1999

 

Campus class subject 【 display / non-display

  • Initial Research Training, Graduate School of Medical and Dental Sciences