Personnel Information

写真a

TAGA Tetsuya


Job title

Professor

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Laboratory Phone number

+81-3-5803-5814

Laboratory Fax number

+81-3-5803-5814

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

Stem Cell Biology, Neural Stem Cell, Hematopoietic Stem Cell, Cancer Stem Cell

Profile

Professor Tetsuya Taga's research at the Department of Stem Cell Regulation has been conducted to elucidate the mechanisms by which stem cells are regulated. The major focus has been on neural stem cells, hematopoietic stem cells, and cancer stem cells. The study is aimed to understand development, maintenance, and regeneration of the central nervous system and the hematopoietic system, and to obtain a clue to tackle the problem of cancer recurrence. Particular attention is given to cell-external cues (such as cytokines) and cell-intrinsic programs (including chromatin modification), taking cross-interactions of transcriptional regulatory signals into consideration.

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Science, Biology: Plant Physiology, 1982, Graduated

Graduate School 【 display / non-display

  • Osaka University, Graduate School, Division of Medicine, Pathology: Immunology, Doctor's Course, 1988, Completed

Degree 【 display / non-display

  • Ph.D., Osaka University

Campus Career 【 display / non-display

  • 2008.12
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Professor
  • 2008.12
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Stem Cell Regulation, Professor
  • 2013.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Vice President

External Career 【 display / non-display

  • 1987.04
    -
    1989.03
    Japan Society for the Promotion of Science, Institute for Molecular and Cellular Biology, Osaka University, Research Fellow
  • 1989.04
    -
    1989.10
    Osaka University, Institute for Molecular and Cellular Biology, Research Fellow
  • 1989.11
    -
    1996.06
    Osaka University, Institute for Molecular and Cellular Biology, Assistant Professor
  • 1996.07
    -
    1996.08
    Osaka University, Institute for Molecular and Cellular Biology, Accociate Professor
  • 1996.09
    -
    2000.08
    Tokyo Medical and Dental University, Medical Research Institute,

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Academic Society Affiliations 【 display / non-display

  • The Japanese Society of Inflammation and Regeneration

  • The Japanese Society for Regenerative Medicine

  • Japanese Society for Immunology

  • The Japanese Cancer Association

  • The Molecular Biology Society of Japan

Academic Activity 【 display / non-display

  • 2002.07
    -
    2021.07
    The Japanese Society of Inflammation and Regeneration Councillor
  • 2013.04
    -
    2021.07
    The Japanese Society of Inflammation and Regeneration Director
  • 2001.05
    -
    2018.10
    The Japanese Society for Regenerative Medicine A delegate
  • 1995.01
    -
    2020.12
    Japanese Society for Immunology Council Member
  • 2001.10
    -
    2006.03
    Director, Institute of Molecular Embryology and Genetics, Kumamoto University

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Research Areas 【 display / non-display

  • Stem Cell Biology

 

Research Theme 【 display / non-display

  • Molecular Regulation of Stem Cells

Published Papers & Misc 【 display / non-display

  • Takahashi S, Nobuhisa I, Saito K, Melig G, Itabashi A, Harada K, Osawa M, Endo AT, Iwama A,Taga T. Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos Differentiation. 2020.09; 115 53-61. ( DOI )

  • Tetsuya Taga and Kouichi Tabu. Glioma progression and recurrence involving maintenance and expansion strategies of glioma stem cells by organizing self-advantageous niche microenvironments. Inflammation and Regeneration. 2020.09; 40 33. ( DOI )

  • Tabu K, Liu W, Kosaku A, Terashima K, Murota Y, Aimaitijiang A, Nobuhisa I, Hide T, Taga T. Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages. Stem cells (Dayton, Ohio). 2020.08; 38 (8): 921-935. ( PubMed, DOI )

  • Nobuhisa Ikuo, Saito Kiyoka, Tsukahara Ryota, Azuma Koya, Melig Gerel, Itabashi Ayumi, Taga Tetsuya. Hematopoiesis and Immune Environment Involvement of TET1 inthe maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  • 椨 康一, 田賀 哲也. グリオーマの新規治療標的としての単球動員がん幹細胞の可視化と検証(Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells) 日本癌学会総会記事. 2019.09; 78回 P-3064. ( ichushi )

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Conference Activities & Talks 【 display / non-display

  • Ikuo Nobuhisa, Ryota Tsukahara, Kiyoka Saito, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Contribution of GIMAP6 expression mediated by transcription factor Sox17 to hematopoietic ability in the aortic lumen of midgestation mouse embryos. The 41th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2020.07.08

  • Alapati Aimaitijiang, Kouichi Tabu, Wenqian Wang, Ikuo Nobuhisa and Tetsuya Taga. Glioma stem cells promote erythroid differentiation in mouse bone marrow. 第41回日本炎症・再生医学会シンポジウム「炎症と発癌・転移の最前線」 2020.07.08

  • Gerel Melig, Ikuo Nobuhisa, Saito Kiyoka, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Role of the Rasip1 in the hematopoiesis of HSC-containing hematopoietic cluster cells in midgestation of mouse embryos. 2020.07.08

  • Ayumi Itabashi, Ikuo Nobuhisa, Yuki Yokoi, Kiyoka Saito, Ryota Tsukahara, Gerel Melig, Tetsuya Taga. Formation of hematopoietic cell clusters and maintenance of undifferentiated state by forced expression of transcription factor Sox17 in a cell population containing hematopoietic stem cells of mouse fetal liver and adult bone marrow. 2020.07.08

  • Nobuhisa I, Saito K, Tsukahara R, Azuma K, Melig G, Itabashi A, Taga T. Involvement of TET1 in the maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.11 Act City Hamamatsu, Hamamatsu, Japan

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Awards & Honors 【 display / non-display

  • ISI Citation Laureate Award "Authoring multiple high impact papers",2000

  • The Japanese Society of Immunology Award,1999

 

Campus class subject 【 display / non-display

  • Initial Research Training, Graduate School of Medical and Dental Sciences