Personnel Information

写真a

KOBAYASHI Hiroaki


Job title

Visiting Lecturer

Laboratory Phone number

+81-3-5803-5488

Research Areas, Keywords

Periodontal Immunology

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Periodontology, Doctor's Course, 2000.03, Completed

Degree 【 display / non-display

  • Ph.D., Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2001.04
    -
    2002.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Dental Resident
  • 2004.04
    -
    2008.05
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Dental Resident
  • 2008.06
    -
    2015.08
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Assistant Professor
  • 2015.09
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Visiting Lecturer
  • 2016.05
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Visiting Lecturer
  • 2017.05
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Visiting Lecturer
  • 2018.05
    -
    2019.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2019.05
    -
    2020.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2020.05
    -
    2021.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2021.05
    -
    2022.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2021.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Visiting Lecturer
  • 2022.05
    -
    2023.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2023.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer

▼display all

External Career 【 display / non-display

  • 2002.04
    -
    2004.03
    University of Toronto, Matrix in Dynamics, Post doctoral fellow

Academic Society Affiliations 【 display / non-display

  • Japanese Society of Periodontology

  • Japanese Society of Conservative Dentistry

  • Japanese Society of Immunology

  • The Japanese Society of Inflammation and Regeneration

Research Areas 【 display / non-display

  • Conservative dentistry

Qualification Acquired 【 display / non-display

  • Labor Hygiene Consultant

 

Published Papers & Misc 【 display / non-display

  1. Hirasawa I, Odagiri H, Park G, Sanghavi R, Oshita T, Togi A, Yoshikawa K, Mizutani K, Takeuchi Y, Kobayashi H, Katagiri S, Iwata T, Aoki A. Anti-inflammatory effects of cold atmospheric plasma irradiation on the THP-1 human acute monocytic leukemia cell line. PloS one. 2023; 18 (10): e0292267. ( PubMed, DOI )

  2. Takahiko Shiba, Keiji Komatsu, Takeaki Sudo, Rikai Sawafuji, Aiko Saso, Shintaroh Ueda, Takayasu Watanabe, Takashi Nemoto, Chihiro Kano, Takahiko Nagai, Yujin Ohsugi, Sayaka Katagiri, Yasuo Takeuchi, Hiroaki Kobayashi, Takanori Iwata. Comparison of Periodontal Bacteria of Edo and Modern Periods Using Novel Diagnostic Approach for Periodontitis With Micro-CT. Front Cell Infect Microbiol. 2021.09; 11 723821. ( PubMed, DOI )

  3. 1. Tanabe G, Hasunuma T, Inai Y, Takeuchi Y, Kobayashi H, Hayashi K, Shimizu S, Kamiya NS, Churei H, Sumita YI, Suzuki K, Moriya N, Ueno T.. Potential Assessment of Dehydration during High-Intensity Training Using a Capacitance Sensor for Oral Mucosal Moisture: Evaluation of Elite Athletes in a Field-Based Survey. Chemosensors. 2021.07; 9 (8): 196. ( DOI )

  4. Nomura Y, Morozumi T, Saito A, Yoshimura A, Kakuta E, Suzuki F, Nishimura F, Takai H, Kobayashi H, Noguchi K, Takahashi K, Tabeta K, Umeda M, Minabe M, Fukuda M, Sugano N, Hanada N, Yoshinari N, Sekino S, Takashiba S, Sato S, Nakamura T, Sugaya T, Nakayama Y, Ogata Y, Numabe Y, Nakagawa T. Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis Journal of Clinical Medicine. 2021.03; 10 (6): 1165. ( DOI )

  5. Ikawa Takahiro, Mizutani Koji, Sudo Takeaki, Kano Chihiro, Ikeda Yuichi, Akizuki Tatsuya, Kobayashi Hiroaki, Izumi Yuichi, Iwata Takanori. Clinical comparison of an electric-powered ionic toothbrush and a manual toothbrush in plaque reduction: A randomized clinical trial INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2021.02; 19 (1): 93-98. ( PubMed, DOI )

  6. Nomura Y, Morozumi T, Numabe Y, Ogata Y, Nakayama Y, Sugaya T, Nakamura T, Sato S, Takashiba S, Sekino S, Yoshinari N, Hanada N, Sugano N, Fukuda M, Minabe M, Umeda M, Tabeta K, Takahashi K, Noguchi K, Kobayashi H, Takai H, Nishimura F, Suzuki F, Kakuta E, Yoshimura A, Saito A, Nakagawa T. Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination Journal of Clinical Medicine. 2021.02; 10 (4): ( PubMed, DOI )

  7. Ikeda Yuichi, Kawada Ayako, Tanaka Daiki, Ikeda Eri, Kobayashi Hiroaki, Iwata Takanori. A comparative questionnaire study of patient complaint levels between magnetostrictive ultrasonic scaler (Cavitron(R)) and piezoelectric ultrasonic scalers INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2020.12; ( PubMed, DOI )

  8. Ye Changchang, Katagiri Sayaka, Miyasaka Naoyuki, Kobayashi Hiroaki, Khemwong Thatawee, Nagasawa Toshiyuki, Izumi Yuichi. The periodontopathic bacteria in placenta, saliva and subgingival plaque of threatened preterm labor and preterm low birth weight cases: a longitudinal study in Japanese pregnant women CLINICAL ORAL INVESTIGATIONS. 2020.12; 24 (12): 4261-4270. ( PubMed, DOI )

  9. Nomura Y, Morozumi T, Fukuda M, Hanada N, Kakuta E, Kobayashi H, Minabe M, Nakamura T, Nakayama Y, Nishimura F, Noguchi K, Numabe Y, Ogata Y, Saito A, Sato S, Sekino S, Sugano N, Sugaya T, Suzuki F, Takahashi K, Takai H, Takashiba S, Umeda M, Yoshie H, Yoshimura A, Yoshinari N, Nakagawa T. Optimal Examination Sites for Periodontal Disease Evaluation: Applying the Item Response Theory Graded Response Model Journal of Clinical Medicine. 2020.11; 9 (11): ( PubMed, DOI )

  10. Ye C, Xia Z, Tang J, Khemwong T, Kapila Y, Kuraji R, Huang P, Wu Y, Kobayashi H. Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery. Scientific Reports. 2020.09; 10 (1): 15807. ( PubMed, DOI )

  11. Ye Changchang, Kobayashi Hiroaki, Katagiri Sayaka, Miyasaka Naoyuki, Takeuchi Yasuo, Kuraji Ryutaro, Izumi Yuichi. The relationship between the anti-Porphyromonas gingivalisimmunoglobulin G subclass antibody and small for gestational age delivery: a longitudinal study in pregnant Japanese women INTERNATIONAL DENTAL JOURNAL. 2020.08; 70 (4): 296-302. ( PubMed, DOI )

  12. 加納 千博, 小林 宏明, 野崎 浩佑, 妻沼 有香, 須藤 毅顕, Khemwong Thatawee, 三神 亮, 和泉 雄一. 生物学的に許容できる歯根面を得るためのルートプレーニング 実験的研究(Effective root planing for biologically acceptable root surfaces: an experimental study) 日本歯周病学会会誌. 2020.03; 62 (1): 1-15. ( ichushi )

  13. Techatanawat S, Surarit R, Chairatvit K, Khovidhunkit W, Roytrakul S, Thanakun S, Kobayashi H, Khovidhunkit SP, Izumi Y. Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis PLoS One. 2020.02; 15 (2): e0228921. ( PubMed, DOI )

  14. Khemwong Thatawee, Kobayashi Hiroaki, Ikeda Yuichi, Matsuura Takanori, Sudo Takeaki, Kano Chihiro, Mikami Ryo, Izumi Yuichi. Fretibacterium sp. human oral taxon 360 is a novel biomarker for periodontitis screening in the Japanese population PLOS ONE. 2019.06; 14 (6): e0218266. ( PubMed, DOI )

  15. Khemwong T, Kobayashi H Ikeda Y, Sudo T, Kano C, Matsuura T, Izumi Y . Eubacterium Saphenum as a Novel Bacterial Biomarker for Periodontitis Screening 口腔病学会雑誌. 2018.07; 85 (2): 62-67.

  16. Khemwong Thatawee, 小林 宏明, 池田 裕一, 須藤 毅顕, 加納 千博, 松浦 孝典, 和泉 雄一. 歯周炎スクリーニングのための新規細菌バイオマーカー Eubacterium saphenum(Eubacterium saphenum as a Novel Bacterial Biomarker for Periodontitis Screening) 口腔病学会雑誌. 2018.07; 85 (2): 62-68. ( ichushi )

  17. Sineepat Talungchit, Waranun Buajeeb, Chotima Lerdtripop, Rudee Surarit, Kongthawat Chairatvit, Sittiruk Roytrakul, Hiroaki Kobayashi, Yuichi Izumi, Siribang-On Piboonniyom Khovidhunkit. Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study. BMC Oral Health. 2018; 18 (1): 42. ( PubMed, DOI )

  18. Yoshiaki Nomura, Toshiya Morozumi, Taneaki Nakagawa, Tsutomu Sugaya, Masamitsu Kawanami, Fumihiko Suzuki, Keiso Takahashi, Yuzo Abe, Soh Sato, Asako Makino-Oi, Atsushi Saito, Satomi Takano, Masato Minabe, Yohei Nakayama, Yorimasa Ogata, Hiroaki Kobayashi, Yuichi Izumi, Naoyuki Sugano, Koichi Ito, Satoshi Sekino, Yukihiro Numabe, Chie Fukaya, Nobuo Yoshinari, Mitsuo Fukuda, Toshihide Noguchi, Tomoo Kono, Makoto Umeda, Osamu Fujise, Fusanori Nishimura, Atsutoshi Yoshimura, Yoshitaka Hara, Toshiaki Nakamura, Kazuyuki Noguchi, Erika Kakuta, Nobuhiro Hanada, Shogo Takashiba, Yasuharu Amitani, Hiromasa Yoshie. Site-level progression of periodontal disease during a follow-up period. PLoS ONE. 2017.12; 12 (12): e0188670. ( PubMed, DOI )

  19. Khemwong Thatawee, Kobayashi Hiroaki, Sudo Takeaki, Kano Chihiro, Izumi Yuichi. Beta-defensins inducing by interleukin-17s in oral epithelial cell CYTOKINE. 2017.12; 100 155.

  20. T Sudo, Y Okada, K Ozaki, K Urayama, M Kanai, H Kobayashi, M Gokyu, Y Izumi, T Tanaka. Association of NOD2 Mutations with Aggressive Periodontitis. J. Dent. Res.. 2017.09; 96 (10): 1100-1105. ( PubMed, DOI )

  21. Kakuta E, Nomura Y, Morozumi T, Nakagawa T, Nakamura T, Noguchi K, Yoshimura A, Hara Y, Fujise O, Nishimura F, Kono T, Umeda M, Fukuda M, Noguchi T, Yoshinari N, Fukaya C, Sekino S, Numabe Y, Sugano N, Ito K, Kobayashi H, Izumi Y, Takai H, Ogata Y, Takano S, Minabe M, Makino-Oi A, Saito A, Abe Y, Sato S, Suzuki F, Takahashi K, Sugaya T, Kawanami M, Hanada N, Takashiba S, Yoshie H. Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. BMC Oral Health. 2017.01; 17 (1): 46. ( PubMed, DOI )

  22. T Morozumi, T Nakagawa, Y Nomura, T Sugaya, M Kawanami, F Suzuki, K Takahashi, Y Abe, S Sato, A Makino-Oi, A Saito, S Takano, M Minabe, Y Nakayama, Y Ogata, H Kobayashi, Y Izumi, N Sugano, K Ito, S Sekino, Y Numabe, C Fukaya, N Yoshinari, M Fukuda, T Noguchi, T Kono, M Umeda, O Fujise, F Nishimura, A Yoshimura, Y Hara, T Nakamura, K Noguchi, E Kakuta, N Hanada, S Takashiba, H Yoshie. Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study. J. Periodont. Res.. 2016.12; 51 (6): 768-778. ( PubMed, DOI )

  23. Supanee Thanakun, Suchaya Pornprasertsuk-Damrongsri, Misa Gokyu, Hiroaki Kobayashi, Yuichi Izumi. Inverse Association of Plasma IgG Antibody to Aggregatibacter actinomycetemcomitans and High C-Reactive Protein Levels in Patients with Metabolic Syndrome and Periodontitis. PLoS ONE. 2016; 11 (2): e0148638. ( PubMed, DOI )

  24. Ogita M, Tsuchida S, Aoki A, Satoh M, Kado S, Sawabe M, Nanbara H, Kobayashi H, Takeuchi Y, Mizutani K, Sasaki Y, Nomura F, Izumi Y. Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis. Lasers in Medical Science. 2015.09; 30 (7): 1855-1866.

  25. Tomonari Suda, Hiroaki Kobayashi, Toshiharu Akiyama, Takuya Takano, Misa Gokyu, Takeaki Sudo, Thatawee Khemwong, Yuichi Izumi. Desensitizing Agent Reduces Dentin Hypersensitivity During Ultrasonic Scaling: A Pilot Study. J Clin Diagn Res. 2015.09; 9 (9): ZC46-ZC49. ( PubMed, DOI )

  26. S. Shimizu, Y. Momozawa, A. Takahashi, T. Nagasawa, K. Ashikawa, Y. Terada, Y. Izumi, H. Kobayashi, M. Tsuji, M. Kubo, and Y. Furuichi2. A Genome-wide Association Study of Periodontitis in a Japanese Population Journal of Dental Research. 2015.02; 11

  27. Ogita M, Tsuchida S, Aoki A, Satoh M, Kado S, Sawabe M, Nanbara H, Kobayashi H, Takeuchi Y, Mizutani K, Sasaki Y, Nomura F, Izumi Y. Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis. Lasers Med Sci.. 2014.12; 28

  28. Misa Gokyu, Hiroaki Kobayashi, Hiromi Nanbara, Takeaki Sudo, Yuichi Ikeda, Tomonari Suda, Yuichi Izumi. Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells. PLoS ONE. 2014; 9 (12): e115107. ( PubMed, DOI )

  29. Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y, Matsushita K, Izumi Y, Nomura F.. Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease. Proteomics. Proteomics. 2013.08;

  30. Changchang Ye, Sayaka Katagiri, Naoyuki Miyasaka, Pariksha Bharti, Hiroaki Kobayashi, Yasuo Takeuchi, Yoshihito Momohara, Masaki Sekiguchi, Satoko Takamine, Toshiyuki Nagasawa, Yuichi Izumi. The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth. Arch. Gynecol. Obstet.. 2013.07; 288 (1): 65-72. ( PubMed, DOI )

  31. Pariksha Bharti, Sayaka Katagiri, Hiroshi Nitta, Toshiyuki Nagasawa, Hiroaki Kobayashi, Yasuo Takeuchi, Hajime Izumiyama, Isao Uchimura, Shuji Inoue, Yuichi Izumi. Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus. Obes Res Clin Pract. 2013; 7 (2): e129-e138. ( PubMed, DOI )

  32. Sayaka Katagiri, Toshiyuki Nagasawa, Hiroaki Kobayashi, Hideyuki Takamatsu, Pariksha Bharti, Hajime Izumiyama, Isao Uchimura, Tadashi Tagami, Takafumi Suzuki, Hiromi Nanbara, Youichi Taniguchi, Sae Hayakumo, Tatsuro Koyanagi, Akiko Himeno-Ando, Maki Goto, Hiroshi Kajio, Yoshihiko Takahashi, Yuichi Izumi, Mitsuhiko Noda. Improvement of glycemic control after periodontal treatment by resolving gingival inflammation in type 2 diabetic patients with periodontal disease. J Diabetes Investig. 2012.08; 3 (4): 402-409. ( PubMed, DOI )

  33. Yasuo Takeuchi, Toshiyuki Nagasawa, Sayaka Katagiri, Satoshi Kitagawara, Hiroaki Kobayashi, Tatsurou Koyanagi, Yuichi Izumi. Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in patients with chronic periodontitis. J. Periodontol.. 2012.06; 83 (6): 766-772. ( PubMed, DOI )

  34. Hiromi Nanbara, Nawarat Wara-aswapati, Toshiyuki Nagasawa, Yasuhiro Yoshida, Reiko Yashiro, Yukiko Bando, Hiroaki Kobayashi, Janjura Khongcharoensuk, Doosadee Hormdee, Waranuch Pitiphat, Jason A Boch, Yuichi Izumi. Modulation of Wnt5a expression by periodontopathic bacteria. PLoS ONE. 2012; 7 (4): e34434. ( PubMed, DOI )

  35. Uraiwan Chokechanachaisakul, Tomoatsu Kaneko, Yusuke Yamanaka, Reika Kaneko, Ken-ichi Katsube, Hiroaki Kobayashi, Jacques E Nör, Takashi Okiji, Hideaki Suda. Gene expression analysis of resident macrophages in lipopolysaccharide-stimulated rat molar pulps. J Endod. 2011.09; 37 (9): 1258-1263. ( PubMed, DOI )

  36. Yuichi Izumi, Akira Aoki, Yoichi Yamada, Hiroaki Kobayashi, Takanori Iwata, Tatsuya Akizuki, Tomonari Suda, Sayaka Nakamura, Nawarat Wara-Aswapati, Minoru Ueda, Isao Ishikawa. Current and future periodontal tissue engineering. Periodontol. 2000. 2011.06; 56 (1): 166-187. ( PubMed, DOI )

  37. Chie Kobayashi, Ken Yaegaki, Bogdan Calenic, Nikolay Ishkitiev, Toshio Imai, Hisataka Ii, Izumi Aoyama, Hiroaki Kobayashi, Yuichi Izumi, Markus Haapasalo. Hydrogen sulfide causes apoptosis in human pulp stem cells. J Endod. 2011.04; 37 (4): 479-484. ( PubMed, DOI )

  38. Marika Takahashi, Zhiyong Chen, Kaoru Watanabe, Hiroaki Kobayashi, Toshiaki Nakajima, Akinori Kimura, Yuichi Izumi. Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese. Open Dent J. 2011; 5 190-194. ( PubMed, DOI )

  39. Toshiyuki Nagasawa, Mitsuhiko Noda, Sayaka Katagiri, Maki Takaichi, Yoshihiko Takahashi, Nawarat Wara-Aswapati, Hiroaki Kobayashi, Satoko Ohara, Yoko Kawaguchi, Tadashi Tagami, Yasushi Furuichi, Yuichi Izumi. Relationship between periodontitis and diabetes - importance of a clinical study to prove the vicious cycle. Intern. Med.. 2010; 49 (10): 881-885. ( PubMed )

  40. Yi-Wen Chen, Toshiyuki Nagasawa, Nawarat Wara-Aswapati, Yuka Ushida, Dongqing Wang, Yasuo Takeuchi, Hiroaki Kobayashi, Makoto Umeda, Yoshinori Inoue, Takehisa Iwai, Isao Ishikawa, Yuichi Izumi. Association between periodontitis and anti-cardiolipin antibodies in Buerger disease. J. Clin. Periodontol.. 2009.10; 36 (10): 830-835. ( PubMed, DOI )

  41. T Suda, T Nagasawa, N Wara-Aswapati, H Kobayashi, K Iwasaki, R Yashiro, D Hormdee, H Nitta, I Ishikawa, Y Izumi. Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells. Oral Microbiol. Immunol.. 2009.10; 24 (5): 384-389. ( PubMed, DOI )

  42. Y Bando, K Noguchi, H Kobayashi, N Yoshida, I Ishikawa, Y Izumi. Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells. J Periodontal Res. 2009.06; 44 (3): 395-401. ( PubMed, DOI )

  43. Yuichi Izumi, Toshiyuki Nagasawa, Makoto Umeda, Hiroaki kobayashi, Yasuo Takeuchi, Reiko Yashiro, Doosadee Hormdee, Tomonari Suda, Yuka Ushida, Nawarat Wara-aswapati. . 28. Periodontitis and cardiovascular diseases: The link and relevant mechanisms. Japanese Dental Sciense Review. 2009; 45 98-108.

  44. D Wang, T Nagasawa, Y Chen, Y Ushida, H Kobayashi, Y Takeuchi, M Umeda, Y Izumi. Molecular mimicry of Aggregatibacter actinomycetemcomitans with beta2 glycoprotein I. Oral Microbiol Immunol. 2008.10; 23 (5): 401-405. ( PubMed, DOI )

  45. Tomohiko Gunji, Yoshihiro Onouchi, Toshiyuki Nagasawa, Sayaka Katagiri, Hisashi Watanabe, Hiroaki Kobayashi, Shinichi Arakawa, Kazuyuki Noguchi, Akira Hata, Yuichi Izumi, Isao Ishikawa. Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. Biochem Biophys Res Commun. 2007.12; 364 (1): 7-13. ( PubMed, DOI )

  46. M Kiji, T Nagasawa, D Hormdee, R Yashiro, H Kobayashi, K Noguchi, H Nitta, Y Izumi, I Ishikawa. Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide. Clin Exp Immunol. 2007.08; 149 (2): 327-334. ( PubMed, DOI )

  47. Tomoe Fukui, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi, Isao Ishikawa. Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells. Drug Metab Lett. 2007.04; 1 (2): 131-135. ( PubMed, DOI )

  48. Toshiyuki Nagasawa, Makoto Kiji, Reiko Yashiro, Doosadee Hormdee, He Lu, Melanie Kunze, Tomonari Suda, Geena Koshy, Hiroaki Kobayashi, Shigeru Oda, Hiroshi Nitta, Isao Ishikawa. Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000. 2007; 43 65-84. ( PubMed, DOI )

  49. R Yashiro, T Nagasawa, M Kiji, D Hormdee, H Kobayashi, G Koshy, H Nitta, I Ishikawa. Transforming growth factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts. J Clin Periodontol. 2006.03; 33 (3): 165-171. ( PubMed, DOI )

  50. D Hormdee, T Nagasawa, M Kiji, R Yashiro, H Kobayashi, G Koshy, K Noguchi, H Nitta, I Ishikawa. Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol. 2005.12; 142 (3): 490-497. ( PubMed, DOI )

  51. Yuguang Gao, Andrew Jheon, Houman Nourkeyhani, Hiroaki Kobayashi, Bernhard Ganss. Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. Gene. 2004.10; 341 101-110. ( PubMed, DOI )

  52. T Nagasawa, H Kobayashi, M Aramaki, M Kiji, S Oda, Y Izumi. Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients. J Periodontal Res. 2004.02; 39 (1): 72-78. ( PubMed, DOI )

  53. Y Gao, H Kobayashi, B Ganss. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). J Dent Res. 2003.12; 82 (12): 1002-1007. ( PubMed, DOI )

  54. Yuya Murakami, Takehisa Kojima, Toshiyuki Nagasawa, Hiroaki Kobayashi, Isao Ishikawa. Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol. 2003.06; 74 (6): 780-786. ( PubMed, DOI )

  55. Makoto Umeda, Hiroaki Kobayashi, Yasuo Takeuchi, Joichiro Hayashi, Yoko Morotome-Hayashi, Kazuko Yano, Akira Aoki, Toshifumi Ohkusa, Isao Ishikawa. High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J Periodontol. 2003.01; 74 (1): 129-134. ( PubMed, DOI )

  56. Bernhard Ganss, Hiroaki Kobayashi. The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation. J Bone Miner Res. 2002.12; 17 (12): 2151-2160. ( PubMed, DOI )

  57. T Nagasawa, H Kobayashi, M Kiji, M Aramaki, R Mahanonda, T Kojima, Y Murakami, M Saito, Y Morotome, I Ishikawa. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol. 2002.11; 130 (2): 338-344. ( PubMed, DOI )

  58. H Kobayashi, T Nagasawa, M Aramaki, R Mahanonda, I Ishikawa. Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria. J Periodontal Res. 2000.12; 35 (6): 319-328. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Shimizu S, Hayashi K, Takeuchi Y, Tanabe G, Churei H, Kobayashi H, Ueno T, Fueki K. Effect of Administration of Sonicated P. gingivalis on skeletal muscle injury healing using a rat model. . ECSS Paris 2023 2023.07.04 Paris

  2. Chihiro Kano, Koji Mizutani, Takahiro Ikawa, Takeaki Sudo, Hiroaki Kobayashi, Yuichi Izumi. The effect of electric-powered ionic toothbrushing on plaque removal – randomized clinical trial –. Europerio9 2018.09.20

  3. Chihiro Kano, Hiroaki Kobayashi, Kosuke Nozaki, Yuka Tsumanuma, Takeaki Sudo, Thatawee Khemwong, Yuichi Izumi. The effective scaling strokes for root planing. The 32nd IADR-SEA Division Annual Scientific Meeting 2018.09.14

  4. T. Khemwong, H. Kobayashi, T. Sudo, C. Kano, T. Matsuura, Y. Ikeda, Y. Izumi. Fretibacterium oral taxon 360 is salivary biomarker for periodontitis. Europerio9 2018.06.23 アムステルダム オランダ

  5. Matsuura T, Ikeda Y, Kobayashi H, Gokyu M, Sakamaki Y, Tsuchiya Y, Nose S, Takahashi Y, Izumi Y. A NOVEL DIAGNOSTIC LOGIC USING SALIVA PATHOGEN AND A SELF-ADMINISTERED QUESTIONNAIRE FOR SCREENING PERIODONTITIS. 101st Annual Meeting of American Academy of Periodontology 2015.11.15 Orland, USA

  6. Misa Gokyu, Hiroaki Kobayashi, Nobuyuki Kawashima, Yuichi Ikeda, Hiromi Nanbara, Takeaki Sudo, Tomonari Suda, Yuichi Izumi. Bacterial evaluation in Periodontal-Endodontic lesion. The International Association for Dental Research (IADR) 2015.03.14

  7. Misa Gokyu, Yuichi Ikeda, Hiroaki Kobayashi, Yuichi Izumi. Quantitative evaluation for counting bacterial cells using synthesis gene. 国際歯科研究学会日本部会総会・学術大会 (JADR) (第62回) 2014.12.05

  8. M.Gokyu, H.Kobayashi, H.Nanbara, Y.Changchang, Y.Izumi. Thrombospondin 1 expression in THP-1 cells stimulated with periodontopathic bacteria. 15th INTERNATIONAL CONGRESS OF IMMUNOLOGY 2013.08.24

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