Personnel Information

写真a

INOUE Katarzyna Anna


Job title

Associate Professor

Laboratory Address

Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549

Laboratory Phone number

+81-3-5803-5449

Laboratory Fax number

+81-3-5803-0187

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

tumor microevironment, heparan sulfate proteoglycan, extracellular matrix
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Degree 【 display / non-display 】

  • Doctor of Engineering, Tokyo Institute of Technology

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Campus Career 【 display / non-display 】

  • 1998.04
    -
    2007.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Research Associate
  • 2001.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Assistant Professor
  • 2007.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Assistant Professor
  • 2021.04
    -
    2024.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Biochemistry， Assistant Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Biochemistry， Associate Professor
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Academic Society Affiliations 【 display / non-display 】

  • Japanese Society for Biochemistry

  • the Japanese Cancer Association

  • Japanese Society for Carbohydrate Research

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Academic Activity 【 display / non-display 】

  • 2013.10
    -
    Now
    Proteoglycan Forum committee member
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Research Areas 【 display / non-display 】

  • Functional biochemistry

  • Cell biology

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Research Theme 【 display / non-display 】

  • Role of TGF-β signals in tumor progression, 2016 - Now

  • Heparan sulfate proteoglycan and cellular logistics, 2002 - Now

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Published Papers & Misc 【 display / non-display 】

  1. Shiori Tokizaki, Katarzyna A Podyma-Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, Kohei Miyazono, Mikako Shirouzu, Tetsuro Watabe. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Sci. 2023.11; ( PubMed, DOI )

  2. Kazuki Takahashi*, Miho Kobayashi*, Hisae Katsumata, Shiori Tokizaki, Tatsuhiko Anzai, Yukinori Ikeda, Daniel M. Alcaide, Kentaro Maeda, Makoto Ishihara, Katsutoshi Tahara, Yoshiaki Kubota, Fumiko Itoh, Jihwan Park, Kunihiko Takahashi, Yukiko T. Matsunaga, Yasuhiro Yoshimatsu, Katarzyna A. Podyma-Inoue, Tetsuro Watabe (*: equally contribution). CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023.11; 115 (2): 490-506. ( PubMed, DOI )

  3. Saranya Serirukchutarungsee, Ippei Watari, Masataka Narukawa, Katarzyna Anna Podyma-Inoue, Pornchanok Sangsuriyothai, Takashi Ono. Two-generation exposure to a high-fat diet induces the change of salty taste preference in rats. Sci Rep. 2023.04; 13 (1): 5742. ( PubMed, DOI )

  4. Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A Podyma-Inoue, Tetsuro Watabe. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition. Inflamm Regen. 2022.09; 42 (1): 38. ( PubMed, DOI )

  5. Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Maki Saito, Shintaro Sakakitan, Akinari Sugauchi, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Kyoko Kurioka, Toru Konishi, Susumu Tanaka, Atsushi Kaida, Masahiko Miura, Shinichi Hashimoto, Mariko Okada, Toshihiro Uchihashi, Kohei Miyazono, Tetsuro Watabe. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3 Cell Reports. 2022.09; 40 111411. ( DOI )

  6. Shingo Kodama, Katarzyna Α Podyma-Inoue, Toshihiro Uchihashi, Kyoko Kurioka, Hitomi Takahashi, Akinari Sugauchi, Kazuki Takahashi, Toshihiro Inubushi, Mikihiko Kogo, Susumu Tanaka, Tetsuro Watabe. Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor. Oncol Rep. 2021.09; 46 (3): ( PubMed, DOI )

  7. Shintaro Sakakitani, Katarzyna A Podyma-Inoue, Rina Takayama, Kazuki Takahashi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroyuki Harada, Tetsuro Watabe. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Cancer Science. 2021.01; 112 (1): 155-167. ( PubMed, DOI )

  8. Kazuki Takahashi, Yuichi Akatsu, Katarzyna A Podyma-Inoue, Takehisa Matsumoto, Hitomi Takahashi, Yasuhiro Yoshimatsu, Daizo Koinuma, Mikako Shirouzu, Kohei Miyazono, Tetsuro Watabe. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. J. Biol. Chem.. 2020.09; 295 (36): 12559-12572. ( PubMed, DOI )

  9. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Cancer Science. 2020.07; 111 (7): 2385-2399. ( PubMed, DOI )

  10. Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, Maeda K, Podyma-Inoue KA, Kajiya K, Matsunaga YT, Watabe T. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. PloS One. 2020.05; 15 (5): e0232356. ( PubMed, DOI )

  11. Yang W, Podyma-Inoue KA, Yonemitsu I, Watari I, Ikeda Y, Guo X, Watabe T, Ono T. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Clinical Oral Investigations. 2020.02; ( PubMed, DOI )

  12. Miki Hara-Yokoyama, Hidetake Kurihara, Shozo Ichinose, Hironori Matsuda, Shizuko Ichinose, Masaru Kurosawa, Norihiro Tada, Chihiro Iwahara, Kazue Terasawa, Katarzyna A. Podyma-Inoue, Koichi Furukawa and Kazuhisa Iwabuchi. KIF11 as a potential marker of spermatogenesis within mouse seminiferous tubule cross-sections. Journal Histochem Cytochem. 2019.08; 22155419871027. ( PubMed, DOI )

  13. Hayato Okamoto, Yasuhiro Yoshimatsu, Taishi Tomizawa, Akiko Kunita, Rina Takayama, Teppei Morikawa, Daisuke Komura, Kazuki Takahashi, Tsukasa Oshima, Moegi Sato, Mao Komai, Katarzyna A Podyma-Inoue, Hiroaki Uchida, Hirofumi Hamada, Katsuhito Fujiu, Shumpei Ishikawa, Masashi Fukayama, Takeshi Fukuhara and Tetsuro Watabe. Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma. Sci Rep. 2019.02; 9 (1): 1281. ( PubMed, DOI )

  14. Ershu Ren, Ippei Watari, Hsu Jui-Chin, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Masataka Narukawa, Takumi Misaka, Tetsuro Watabe, Takashi Ono. Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae. Acta Histochem.. 2019.02; 121 (2): 135-142. ( PubMed, DOI )

  15. Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Chihiro Takao, Yasuhiro Yoshimatsu Y, Tomoki Muramatsu, Johji Inazawa and Tetsuro Watabe. Regulatory role of transforming growth factor-β signals in the migration and tumor formation of HOC313-LM cells, an oral squamous cell carcinoma Journal Stomatological Society, Jpn. 2018.07; 85 (2): 52-61.

  16. Rie Norita, Yasuhiro Suzuki, Yutaka Furutani, Kazuki Takahashi, Yasuhiro Yoshimatsu, Katarzyna A Podyma-Inoue, Tetsuro Watabe, Yasufumi Sato. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling. Cancer Sci.. 2017.03; 108 (3): 419-426. ( PubMed, DOI )

  17. Takashi Ode, Katarzyna A Podyma-Inoue, Kazue Terasawa, Jin-Ichi Inokuchi, Toshihide Kobayashi, Tetsuro Watabe, Yuichi Izumi, Miki Hara-Yokoyama. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum. Exp. Cell Res.. 2017.01; 350 (1): 103-114. ( PubMed, DOI )

  18. Katarzyna A Podyma-Inoue, Takuya Moriwaki, Anupama R Rajapakshe, Kazue Terasawa, Miki Hara-Yokoyama. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016.12; 13 (6): 443-452. ( PubMed )

  19. Kazue Terasawa, Yuri Tomabechi, Mariko Ikeda, Haruhiko Ehara, Mutsuko Kukimoto-Niino, Motoaki Wakiyama, Katarzyna A Podyma-Inoue, Anupama R Rajapakshe, Tetsuro Watabe, Mikako Shirouzu, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 489-495. ( PubMed, DOI )

  20. Kazue Terasawa, Anupama R Rajapakshe, Katarzyna A Podyma-Inoue, Chiemi Mishima-Tsumagari, Masaki Yanagishita, Miki Hara-Yokoyama. Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL. J. Immunol. Methods. 2015.05; ( PubMed, DOI )

  21. Anupama R Rajapakshe, Katarzyna A Podyma-Inoue, Kazue Terasawa, Katsuya Hasegawa, Toshimitsu Namba, Yasuhiro Kumei, Masaki Yanagishita, Miki Hara-Yokoyama. Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. Exp. Cell Res.. 2015.02; 331 (1): 211-222. ( PubMed, DOI )

  22. Emina Aoyama, Ippei Watari, Katarzyna Anna Podyma-Inoue, Masaki Yanagishita, Takashi Ono. Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. Int. J. Mol. Med.. 2014.08; 34 (2): 475-482. ( PubMed, DOI )

  23. Jutiporn Privatananupunt, Ippei Watari, Katarzyna Anna Podyma-Inoue, Mariko Kubono, Takashi Ono. Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands. Acta Histochem.. 2014.05; 116 (4): 545-550. ( PubMed, DOI )

  24. Kasevayuth Kasekarn, Katarzyna A. Podyma-Inoue and Masaki Yanagishita. Effect of lipopolysaccharide from Porphyromonas gingivalis on expression of heparanase in human gingival epithelial cell line, Ca9-22 Chulalongkorn University Dental Journal. 2013.12; 36 (3): 143-152.

  25. Sachiko Takehara, Masaki Yanagishita, Katarzyna Anna Podyma-Inoue, Yoko Kawaguchi. Degradation of MUC7 and MUC5B in human saliva. PLoS ONE. 2013.07; 8 (7): e69059. ( PubMed, DOI )

  26. Miki Hara-Yokoyama, Kazue Terasawa, Shizuko Ichinose, Akihiko Watanabe, Katarzyna A Podyma-Inoue, Kazunari Akiyoshi, Yasuyuki Igarashi, Masaki Yanagishita. Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. Bioorg. Med. Chem. Lett.. 2013.04; 23 (7): 2220-2224. ( PubMed, DOI )

  27. Miki Hara-Yokoyama, Mutsuko Kukimoto-Niino, Kazue Terasawa, Satoru Harumiya, Katarzyna A Podyma-Inoue, Nobumasa Hino, Kensaku Sakamoto, Satsuki Itoh, Noritaka Hashii, Yoko Hiruta, Nana Kawasaki, Chiemi Mishima-Tsumagari, Yoko Kaitsu, Tomoko Matsumoto, Motoaki Wakiyama, Mikako Shirouzu, Takeshi Kasama, Hiroshi Takayanagi, Naoko Utsunomiya-Tate, Kiyoshi Takatsu, Toshiaki Katada, Yoshio Hirabayashi, Shigeyuki Yokoyama, Masaki Yanagishita. Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities. Structure. 2012.09; 20 (9): 1585-1595. ( PubMed, DOI )

  28. Katarzyna A Podyma-Inoue, Miki Hara-Yokoyama, Tamayuki Shinomura, Tomoko Kimura, Masaki Yanagishita. Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. PLoS ONE. 2012.03; 7 (3): e32351. ( PubMed, DOI )

  29. N Ebe, M Hara-Yokoyama, K Iwasaki, S Iseki, S Okuhara, K A Podyma-Inoue, K Terasawa, A Watanabe, T Akizuki, H Watanabe, M Yanagishita, Y Izumi. Pocket epithelium in the pathological setting for HMGB1 release. J. Dent. Res.. 2011.02; 90 (2): 235-240. ( PubMed, DOI )

  30. Sachiko Takehara, Masaki Yanagishita, Katarzyna Anna Podyma-Inoue, Masayuki Ueno, Kayoko Shinada, Yoko Kawaguchi. Relationship between oral malodor and glycosylated salivary proteins. J. Med. Dent. Sci.. 2010.03; 57 (1): 25-33. ( PubMed )

  31. Masaki Yanagishita, Katarzyna Anna Podyma-Inoue, Miki Yokoyama. Extraction and separation of proteoglycans. Glycoconj. J.. 2009.11; 26 (8): 953-959. ( PubMed, DOI )

  32. Rubia A Dias, Shunichi Shibata, Mariko Hashimoto-Uoshima, Katarzyna A Podyma-Inoue, Isao Ishikawa, Masaki Yanagishita. Syndecan-1 expression during the formation of junctional epithelium. J. Periodontol.. 2005.05; 76 (5): 696-704. ( PubMed, DOI )

  33. Sachio Tsuchida, Katarzyna A Podyma-Inoue, Masaki Yanagishita. Ultrafiltration-based assay for heparanase activity. Anal. Biochem.. 2004.08; 331 (1): 147-152. ( PubMed, DOI )

  34. Hitoshi Kurokawa, Ken-ichi Katsube, Katarzyna A Podyma, Minoru Ikuta, Hachirou Iseki, Motowo Nakajima, Takumi Akashi, Ken Omura, Minoru Takagi, Masaki Yanagishita. Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts. Cancer Sci.. 2003.03; 94 (3): 277-285. ( PubMed )

  35. Katarzyna A Podyma-Inoue, Hideyuki Yokote, Kazushige Sakaguchi, Minoru Ikuta, Masaki Yanagishita. Characterization of heparanase from a rat parathyroid cell line. J. Biol. Chem.. 2002.09; 277 (36): 32459-32465. ( PubMed, DOI )

  36. M Ikuta, K A Podyma, K Maruyama, S Enomoto, M Yanagishita. Expression of heparanase in oral cancer cell lines and oral cancer tissues. Oral Oncol.. 2001.02; 37 (2): 177-184. ( PubMed )

  37. Katarzyna A. Podyma, Sadako Yamagata, Kyoko Sakata and Tatasuya Yamagata. Difference of hyaluronidase produced by human tumor cell lines with hyaluronidase present in human serum as revealed by zymography. Biochem. Biophys. Res. Commun.. 1997.12; 241 (2): 446-452. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  1. Ippei Watari, Mona Aly Abbassy, Katarzyna Anna Podyma-Inoue and Takashi Ono. Major Topics in Type 1 Diabetes, Dr. Kenia Nunes (Ed.). InTech， 2015.11 Complication of Type 1 Diabetes in Craniofacial and Dental Hard Tissue (ISBN : 978-953-51-2204-3)

  2. Masaki Yanagishita and Katarzyna A. Inoue (N. Taniguchi et al. Editors). Experimental Glycoscience: Glycobiology; N. Taniguchi et al. (Eds). Springer， 2008.08 Golgi and Lysosomal Disease: Degradation of hyaluronan and its disorder (ISBN : 978-4431779216)

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Conference Activities & Talks 【 display / non-display 】

  1. Halder Semanti, Yasuyuki Hanada, Yuka Ozeki, Honami Ogo, Yumi Omine, Katarzyna Inoue, Tetsuro Watabe, Akiyoshi Uemura and Koichi Nishiyama. Endothelial cell-pericyte interaction facilitates the establishment of vascular basement membrane with type-4 collagen deposition via Tgfb2-Alk5 in angiogenesis. The 96th Annual Meeting of the Japanese Biochemical Society 2023.11.01 Fukuoka

  2. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Shintaro Sakakitani, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Toru Konishi, Susumu Tanaka, Atsushi Kaida, Masahiko Miura, Shinichi Hashimoto, Mariko Okada, Toshihiro Uchihashi, Kohei Miyazono, Tetsuro Watabe. TGF-β confers cancer cells with the high motility and metastatic potential via induction of Slug/HMGA2-independent EMT. The 82nd Annual Meeting of the Japanese Cancer Association 2023.09.23 Yokohama

  3. Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Yukinori Ikeda, Tatsuhiko Anzai, Katarzyna A. Podyma-Inoue, Daniel M Alcaide, Kentaro Maeda, Jihwan Park, Kunihiko Takahashi, Yukiko Matsunaga, Yasuhiro Yoshimatsu, Tetsuro Watabe. Endothelial-mesenchymal transition (EndoMT) reporter cells visualized multiple groups of cells during progression of TGF-β induced EndoMT. Asia-Australia Vascular Biology Meeting 2023 (AAVBM 2023) 2023.09.14 Seoul, Korea

  4. Katarzyna Inoue. Inhibition of TGF-β signals by a chimeric Fc receptor suppresses tumor formation by regulation of tumor microenvironment networks. TGFβ Meeting 2023.08.17 Uppsala, Sweden

  5. Katarzyna A. Inoue. TGF-β generates cancer cells residing in G1 phase with high motility by inducing Slug/HMGA2-independent EMT. Virtual TGF-β Meeting 2022.08.17 on-line

  6. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Shintaro Sakakitani, Toru Konishi, Daizo Koinuma, Akinari Sugauchi, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. TGF-β-induced cell cycle arrest is correlated with increased migration and metastasis of oral squamous cell carcinoma. The 46th Meeting of the Japanese Society of Lymphology 2022.06.04 Tokyo

  7. Yasuhiro Yoshimatsu, Kentaro Maeda, Naoya Takahashi, Ikumi Wakabayashi, Shiori Kimuro, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Masanori Hirashima, Kohei Miyazono, Tetsuro Watabe . Role of an ETS family transcription factor in endothelial mesenchymal transition (EndoMT)-driven EMT. 第80回日本癌学会学術総会 2021.10.01

  8. Katarzyna A. Inoue, Kazuki Takahashi, Sakakitani Shintaro, Daizo Koinuma, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. Activation of epithelial-mesenchymal transition program in oral cancer cells under TGF-β-induced cell cycle arrest. TGF-β Superfamily Conference: Signaling in Development and Disease (FASEB) 2021.07.20

  9. Katarzyna A. Inoue, Shintaro Sakakitani, Kazuki Takahashi, Hiroyuki Harada, Tetsuro Watabe. Novel approach for treatment of oral squamous cell carcinoma. 第79回日本癌学会学術総会 2020.10.03 広島

  10. Kazuki Takahashi, Katarzyna A. Inoue, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. 第79回日本癌学会学術総会 2020.10.01 広島

  11. Yasuhiro Yoshimatsu, Ikumi Wakabayashi, Shiori Kimuro, Naoya Takahashi, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Kohei Miyazono, Tetsuro Watabe. Endothelial-derived TGF-β signals activated during ednothelial-to-mesenchymal transition induce EMT of oral cancer cells. 第79回日本癌学会学術総会 2020.10.01

  12. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. Oral squamous carcinoma cells under TGF-β-induced cell cycle arrest represent highly motile and invasive population. AACR Virtual Special Conference: Tumor Heterogeneity: From Single Cells to Clinical Impact 2020.09.17

  13. Katarzyna Inoue, Rina Takayama, Kazuki Takahashi, Tetsuro Watabe. Characterization of exosomes secreted from oral squamous carcinoma cells during epithelial to mesenchymal transition. Proteoglycans 2019 2019.10.01 Kanazawa, Japan

  14. Katarzyna A. Inoue, Kazuki Takahashi, Yasuhiro Yoshimatsu, Akinari Sugauchi, Kei Takahashi, Shimpei I. Kubota, Toshihiro Uchihashi, Atsushi Kaida, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Kohei Miyazono and Tetsuro Watabe. Highly motile oral squamous carcinoma cells responding to TGF-β are under cell cycle arrest. Keystone Symposia; Cancer Metastasis: The role of metabolism, immunity and microenvironment 2019.03.17 Florence, Italy

  15. Kazuki Takahashi, Katarzyna A. Inoue, Yasuhiro Yoshimatsu, Atsushi Kaida, Kei Takahashi, Shimpei Kubota, Akinari Sugauchi, Toshihiro Uchihashi, Susumu Tanaka, Mikihiko Kogo, Masahiko Miura, Kohei Miyazono and Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. AACR-JCA Joint Conference 2019.02.09

  16. Katarzyna A. Inoue, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Miki Yokoyama and Tetsuro Watabe. Exosomes secreted by oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition. ConBio2017 2017.12.06 Kobe

  17. Tetsuro Watabe, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Atsushi Kaida, Masahiko Miura and Katarzyna A. Inoue. Relationship between cell cycle arrest and epithelial to mesenchymal transition (EMT) induced by TGF-β in oral squamous carcinoma cell. ERATO/AMED-CREST/PRESTO Joint International Symposium 2017.12.04 京都

  18. Katarzyna A. Inoue, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Atsushi Kaida, Masahiko Miura and Tetsuro Watabe. Cell cycle arrest in oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition. FASEB Conference "TGF-B Superfamily: Signaling in Development and Disease" 2017.07.10 Lisbon, Portugal

  19. Ershu Ren, Ippei Watari, Hsu Jui-Chin, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono. Unilateral nasal obstruction effects gustatory function in rats. The 39 th Annual Scientific Conference on Dental Research 2017.03.31 Ho Chi Minh City, Vietnam

  20. Katarzyna Anna Inoue. Role of TGF-β in invasiveness of oral carcinoma cells. H28 Workshop for young investigators, Intractable disease (Cancer) 2016.10.15 Tokyo, Japan

  21. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Tetsuro Watabe. Characterization of extracellular vesicles isolated from osteoblastic cells lines. The 89th Annual Meeting of Japanese Biochemistry Society 2016.09.27 Sendai, Japan

  22. Anupama R. Rajapakshe, Katarzyna A. Podyma-Inoue, Kazue Terasawa, and Miki Hara-Yokoyama. Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. The Pathobiology of the Lysosome and Lysosomal Diseases Conference 2016.07.07 Cambridge, England

  23. Ershu Ren, Ippei Watari, Jui-Chin Hsu, Rieko Ono, Emina Wakasugi-Aoyama, Mariko Mizumachi-Kubono, Katarzyna A. Podyma-Inoue, Tetsuro Watabe, Takashi Ono. Unilateral nasal obstruction affects taste cells in circumvallate papillae in rat. The 17th International symposium on olfaction and taste (ISOT2016) 2016.05.06 Yokohama, Japan

  24. Beauboeuf Roody, Ippei Watari, Jui-Chin Hsu, Mariko Mizumachi-Kubono, Katarzyna A. Podyma-Inoue, Tetsuro Watabe, Takashi Ono. Expression of GLP-1 and GLP-1 receptor in rat circumvallate papillae during growth period. The 17th International symposium on olfaction and taste (ISOT2016) 2016.05.06 Yokohama, Japan

  25. Katarzyna A. Podyma-Inoue, Anupama R. Rajapakshe, Takuya Moriwaki, Tetsuro Watabe and Miki Yokoyama. Heparan sulfate proteoglycan and intracellular transport; clues from proteomic analysis of transport vesicles. BMB2015 2015.12.03 Kobe

  26. Ippei Watari, Katarzyna A. Podyma-Inoue, Ikuo Yonemitsu, Mutsumi Miyazaki and Takashi Ono. Altered craniofacial morphogenesis in the offspring of rats with gestational diabetes. The 91st Congress of the European Orthodontic Society 2015.06.13 Venice, Italy

  27. Takashi Ode, Katarzyna A. Podyma-Inoue, Shinichi Arakawa, Miki Yokoyama, Yuichi Izumi. Intracellular cholesterol trafficking is involved in osteoblastic differentiation of MC3T3-E1 cells. The 58th Spring Meeting of the Japanese Society of Periodontology 2015.05.15 Chiba, Makuhari

  28. Anupama R. Rajapakshe, Katarzyna A. Podyma-Inoue, Takashi Ode, Miki Hara-Yokoyama. Lysosome-associated memebrane proteins (LAMPs) regulate bidirectional transport of lysosomes in MC3T3-E1 cells. The 58th Spring Meeting of the Japanese Society of Periodontology 2015.05.15 Chiba, Makuhari

  29. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita. Heparan sulfate proteoglycan and its putative role in trafficking of transglutaminase 2. The 87th Annual Meeting of Japanese Biochemistry Society 2014.10.18 Kyoto

  30. Ippei Watari, Emina Aoyama-Wakasugi, Katarzyna A. Podyma-Inoue, Masaki Yanagishita and Takashi Ono. Changes in the expression of incretin receptors in mouse osteoblastic cell line in response to various glucose concentration. The 17th International Symposium on Molecular Medicine 2014.10.09 Athens, Greece

  31. Katarzyna A. Podyma-Inoue. Role of heparan sulfate proteoglycan in etiology of neurodegenerative disease. The 21st Proteoglycan Forum 2014.01.12 Tokyo, Japan

  32. Ysuhiro Kumei, Jorge L. Zeredo, Katarzyna A. Podyma-Inoue, Katsuya Hasegawa, and Shuji Aou. X-ray movie visualization for differential thresholds of mouse adaptation to low gravities. The 29th American Society for Gravitational and Space Research 2013.11 Orlando, U.S.A.

  33. Anupama Rajapakshe, Katarzyna A. Podyma-Inoue, Masaki Yanagishita and Miki Yokoyama. LAMP2 is involved in the intracellular transport of RANKL. The 55th Annual Meeting of Japnese Association for Oral Biology 2013.09 Okayama, Japan

  34. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita. Cell surface heparan sulfate proteoglycans expressed by mouse glioma cells: biochemical characterization. The 8th International Conference on Proteoglycans 2013.08 Frankfurt/Main, Germany

  35. Jutiporn Privatananupunt, Ippei Watari, Katarzyna A. Podyma-Inoue, Mariko Kubono, Masaki Yanagishita and Takashi Ono. Glucose-dependent insulinotropic polypeptide expression in the rat major salivary glands. The 2nd Meeting of the International Association for Dental Research – Asia Pacific Region 2013.08 Bangkok, Thailand

  36. Jutiporn Privatananupunt, Ippei Watari, Katarzyna A. Podyma-Inoue, Mariko Kubono, Ikuko Hattori, Koji Honda, Yuji Ishida, Masaki Yanagishita and Takashi Ono. Expression of GIP and its receptor in the major salivary glands. The 71st Japanese Orthodontic Society Meeting 2012.09 Morioka, Japan

  37. Yasuhiro Kumei, Katsuya Hasegawa, Shuji Aou, Jorge L. Zeredo, Kimiya Narikiyo, Katarzyna A. Inoue, Yukio Maezawa, and Yuuki Watanabe. A novel centrifuge for animal physiological researches in hypergravity and variable gravity forces. 39th COSPAR Scientific Assembly 2012.07 Mysore, India

  38. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita. Association of heparan sulfate proteoglycans with trypsin-accessible membrane domains. Gordon Research Conference Proteoglycans, Proctor Academy, Andover - U.S.A. 2012.07 Proctor Academy, Andover, U.S.A.

  39. Shuji Aou, Kimiya Narikiyo, Jorge L. Zeredo, Katarzyna Inoue, Yuuki Watanabe, Katsuya Hasegawa and Yasuhiro Kumei. Social and sexual behaviours of mice in partial gravity. 39th COSPAR Scientific Assembly 2012.07 Mysore, India

  40. Yasuhiro Kumei, Katsuya Hasegawa, Jorge L. Zeredo, Kimiya Narikiyo, Katarzyna A. Inoue, Yuuki Watanabe, Yukio Maezawa, Noriaki Ishioka, Masamichi Yamashita, and Shuji Aou. Rodents response to lunar and martian gravity: posture, behavior, and neuronal activity in partial gravity. The 27th ASGSB/The 32th ISGP Joint Conference 2011.11 San Jose, U.S.A.

  41. Katsuya Hasegawa, Jorge L. Zeredo, Masamitsu Kawamoto, Kimiya Narikiyo, Katarzyna A. Inoue, Shuji Aou, and Yasuhiro Kumei. Development of a novel centrifuge for gravitational research in life sciences. The 27th ASGSB/The 32th ISGP Joint Conference 2011.11 San Jose, U.S.A.

  42. Analysis of neurotransmitters/neuromodulators released under low gravity using microdialysis technique. The 34 Annual Meeting of Japanese Neuroscience Society, Yokohama - Japan 2011.09

  43. Sachiko Takehara, Masaki Yanagishita, Katarzyna A. Podyma-Inoue, Masayuki Ueno, Kayoko Shinada and Yoko Kawaguchi. Proteolytic degradation of human salivary MUC5B and MUC7. Symposium "toward networking dental professionals in Asia" 2011.09 Tokyo, Japan

  44. Yasuhiro Kumei, Katarzyna A. Inoue, Jorge L. Zeredo, Katsuya Hasegawa, Yukio Maezawa, Kimiya Narikiyo, Akira Masuda and Shuji Aou. Rodent neuroscience in low-gravity conditions. The 34th Annual Meeting of the Japan Neuroscience Society 2011.09 Yokohama, Japan

  45. Katarzyna A. Inoue, Kimiya Narikiyo, Jorge L. Zeredo, Akira Masuda, Shuji Aou, Yasuhiro Kumei. Analysis of neurotransmitters/neuromodulators released under low gravity using microdialysis technique. The 34th Annual Meeting of the Japan Neuroscience Society 2011.09 Yokohama, Japan

  46. Yasuhiro Kumei, Katarzyna A. Inoue, Jorge L. Zeredo, Katsuya Hasegawa, Yukio Maezawa, Kimiya Narikiyo, Akira Masuda and Shuji Aou. Novel approaches to the study of rodent neuroscience in partial- and microgravity. ELGRA Biennial Symposium and General Assembly 2011.09 Antwerp, Belgium

  47. Jorge L. Zeredo, Katarzyna A. Inoue, Kimiya Narikiyo, Akira Masuda, Shuji Aou and Yasuhiro Kumei. Neuronal response of the hypothalamic arcuate nucleus to partial-gravity levels in rats. ELGRA Biennial Symposium and General Assembly 2011.09 Antwerp, Belgium

  48. Katarzyna A. Inoue. Life is not only wine and roses? - climbing up Japanese social ladder. The 84th Annual Meeting of Japanese Biochemical Society 2011.09 Kyoto, Japan

  49. Sachiko Takehara, Masaki Yanagishta, Katarzyna A. Podyma-Inoue, Masayuki Ueno, Kayoko Shinada and Yoko Kawaguchi. Proteolytic degradation of human salivary MUC5B and MUC7. The 89th IADR/AADR/CADR 2011.03 Tokyo, Japan

  50. Katarzyna A. Podyma-Inoue. Analysis of neurotransmitters/neuromodulators released under low gravity using microdialysis technique. 平成23年度JAXA研究班会議 「月・火星重力と生命科学」研究班会議 2011.03 東京都

  51. N. Ebe, M. Hara-Yokoyama, K. Iwasaki, S. Iseki, S. Okuhara, K. A. Podyma-Inoue, K. Terasawa, T. Akizuki, H. Watanabe, M. Yanagishita and Y. Izumi. Pocket epithelium in the pathological setting for HMGB1 release. The 88th IADR General Session 2010.08 Barcelona, Spain

  52. Sachiko Takehara, Masaki Yanagishta, Katarzyna A. Podyma-Inoue, Masayuki Ueno, Kayoko Shinada and Yoko Kawaguchi. Proteolytic degradation of human salivary MUC5B and MUC7. The 25th International Carbohydrate Symposium (ICS2010) 2010.08 Tokyo, Japan

  53. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita. Association of heparan sulfate proteoglycans with membrane rafts. Gordon Research Conference Proteoglycans 2010.07 Proctor Academy, Andover, U.S.A.

  54. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita. Heparan sulfate proteoglycans on the plasma membrane; association with detergent-resistant membranes. The 6th International Conference on Proteoglycans 2009.09 Aix-les-Bains, France

  55. Sachiko Takehara, Masaki Yanagishta, Katarzyna A.Podyma-Inoue, Masayuki Ueno, Kayako Shinada and Yoko Kawaguchi. Comparison of glycosylated and total salivary proteins between halitosis and non-halitosis patients. International Conference of Asian Academy of Preventive Dentistry 2008.11 Jeju, Korea

  56. Katarzyna A. Inoue, Miki Yokoyama, Tomoko Kimura. Heparan sulfate proteoglycans on the plasma membrane; association with detergent-resistant membranes. The 15th Proteoglycan Forum 2007.10 Tokyo, Japan

  57. Katarzyna A. Podyma-Inoue, Miki Yokoyama, Tomoko Kimura and Masaki Yanagishita. Syndecan-4 is a major heparan sulfate proteoglycan in detergent-resistant membranes isolated from a parathyroid cell line. Satellite Symposium of IUBMB 2006, Extracellular Glycomatrix in Health and Disease 2006.06 Awaji Island, Japan

  58. Masaki Yanagishita and Katarzyna A. Podyma-Inoue. Role of heparanase in the catabolism of cell surface heparan sulfate proteoglycan. The 2nd Netherlands-Japan Glycobiology Symposium 2005.04 Utrecht、the Netherlands

  59. Katarzyna A. Podyma-Inoue, Miki Yokoyama, Tomoko Kimura, Osamu Katsumata and Masaki Yanagishita. Heparan sulfate proteoglycans are present in detergent-resistant membranes isolated from a rat parathyroid cell line. US/Japan Glyco 2004.11 Honolulu, Hawaii

  60. 21. Katarzyna A. Podyma-Inoue, Miki Yokoyama, Tomoko Kimura, Osamu Katsumata and Masaki Yanagishita. Localization of heparan sulfate proteoglycans in lipid rafts isolated from a rat parathyroid cell line. The 77th Japanese Biochemical Society Meeting 2004.10 Yokohama, Japan

  61. Rubia A. Dias, Shunichi Shibata, Mariko Hashimoto-Uoshima, Katarzyna A. Podyma-Inoue, Masaki Yanagishita and Isao Ishikawa. Dynamics of syndecan family protein expression in junctional epithelium formation. The 82th International Association of Dental Research Meeting 2004.03 Honolulu, Hawaii

  62. Katarzyna A. Podyma-Inoue. Heparanase Role in Cancer and Physiology. The 10th Proteoglycan Forum "Proteoglycans and Disorders - The Latest insights" 2004.01

  63. Kasekarn Kasevayuth, Katarzyna A. Podyma-Inoue and Masaki Yanagishita. Endocytosis and intracellular degradation of heparan sulfate proteoglycans. International Symposium on Biological Science of Heparan Sulfate Proteoglycans - Kyoto 2003.04 Kyoto, Japan

  64. 尾崎 周作、金香 佐和、Katarzyna A. Podyma-Inoue、柳下 正樹、相馬 邦道 . 機能的刺激が歯根膜由来細胞の細胞外マトリックス産生に及ぼす影響の定量的検討. 第44回歯科基礎医学会学術大会・総会 2002.10

  65. Rubia A. Dias, Mariko Hashimoto-Uoshima, Katarzyna A. Podyma, Kazuyuki Noguchi and Masaki Yanagishita. Effects of Cytokines on Proteoglycan Expression in Periodontal Tissue Cells. The 80th IADR/AADR/CADR Annual Meeting 2002.03 San Diego, U.S.A.

  66. Masaki Yanagishita and Katarzyna A. Podyma. Inhibitors of heparanase. Gordon Conference on Proteoglycans 2000.07 Proctor Academy, NH

  67. Minoru Ikuta, Katarzyna A. Podyma, Hitoshi Kurokawa, Shouji Enomoto and Masaki Yanagishita. Degradation of heparan sulfate proteoglycans by human oral cancer cell lines. The 39th Annual Meeting of the American Society for Cell Biology 1999.12 Washington D.C., U.S.A.

  68. Masaki Yanagishita, Minoru Ikuta and Katarzyna A. Podyma. Characterization of Heparanase from a Rat Parathyroid Cell Line (PTr). International Conference on Molecular Interactions of Proteoglycans 1999.08 Shonan Village Center (Kanagawa), Japan

  69. Masaki Yanagishita, Minoru Ikuta and Katarzyna A. Podyma. Role of heparanase in the metabolism of cell surface proteoglycan. XV International Symposium on Glycoconjugates 1999.08 Tokyo, Japan

  70. Katarzyna A. Podyma and Jan Szopa. Analysis of expression of gene encoding plant matrix endonuclease 32kDa. The 1st International Seminar on Nuclear Matrix 1994.06 Lagow、Poland

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Others 【 display / non-display 】

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Campus class subject 【 display / non-display 】

  • Molceular basis of the life and the cell: laboratory，2007 - Now

  • Molceular basis of the life and the cell: Extracellular matrix，2016 - Now

  • Molecular and Cellular Biology: Structure, function and turnover of extracellular matrix，2018 - Now

  • Nutrition and metabolism (metabolism of sugars, lipids and proteins)，2016 - Now

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