Seiko Ishihara, Risa Usumi-Fujita, Yuki Kasahara, Shuji Oishi, Kana Shibata, Yasuhiro Shimizu, Yuji Ishida, Sawa Kaneko, Makoto Sugiura-Nakazato, Makoto J Tabata, Jun Hosomichi, Yoshiaki Taniyama, Takashi Ono. Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy. J Bone Miner Metab. 2023.03; 41 (2): 171-181. ( PubMed, DOI )

Albert Chun-Shuo Huang, Yuji Ishida, Kai Li, Duantawan Rintanalert, Kasumi Hatano-Sato, Shuji Oishi, Jun Hosomichi, Risa Usumi-Fujita, Hiroyuki Yamaguchi, Hiroyuki Tsujimoto, Aiko Sasai, Ayaka Ochi, Hajime Watanabe, Takashi Ono. NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption. Int J Mol Sci. 2023.02; 24 (4): ( PubMed, DOI )

Wirongrong Wongkitikamjorn, Eiji Wada, Jun Hosomichi, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Ken-Ichi Yoshida, Takashi Ono, Yukiko K Hayashi. Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia. Front Physiol. 2023.01; 14 1067683. ( PubMed, DOI )

Hideyuki Maeda, Jun Hosomichi, Akihiro Hasumi, Ken-Ichi Yoshida. Influence of cardiac function on intermittent hypoxia in rats fed with high-fat diet. Biochem Biophys Rep. 2022.12; 32 101393. ( PubMed, DOI )

Wirongrong Wongkitikamjorn, Jun Hosomichi, Eiji Wada, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Yukiko K Hayashi, Ken-Ichi Yoshida, Takashi Ono. Gestational Intermittent Hypoxia Induces Mitochondrial Impairment in the Geniohyoid Muscle of Offspring Rats. Cureus. 2022.05; 14 (5): e25088. ( PubMed, DOI )

Narubhorn Ongprakobkul, Yuji Ishida, Kasumi Hatano-Sato, Kai Li, Sirima Petdachai, Risa Usumi-Fujita, Jun Hosomichi, Korapin Mahatumarat, Takashi Ono. Effects of local vs systemic administration of CXCR4 inhibitor AMD3100 on orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop. 2022.03; ( PubMed, DOI )

Li K, Ishida Y, Hatano-Sato K, Ongprakobkul N, Hosomichi J, Usumi-Fujita R, Kaneko S, Yamaguchi H, Ono T. Nuclear factor-kappa B decoy oligodeoxynucleotide-loaded poly lactic-co-glycolic acid nanospheres promote periodontal tissue healing after tooth replantation in rats. J Periodontol. 2021.07; ( PubMed, DOI )

Hong H, Hosomichi J, Maeda H, Ishida Y, Usumi-Fujita R, Yoshida KI, Ono T. Selective β2-Adrenoceptor Blockade Rescues Mandibular Growth Retardation in Adolescent Rats Exposed to Chronic Intermittent Hypoxia. Front Physiol. 2021.06; 12 676270. ( PubMed, DOI )

Yo-Ichiro Kuma, Jun Hosomichi, Hideyuki Maeda, Shuji Oishi, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Jun-Ichi Suzuki, Ken-Ichi Yoshida, Takashi Ono. Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats. Sleep Breath. 2021.06; 25 (2): 677-684. ( PubMed, DOI )

Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Ishida Y, Usumi-Fujita R, Kaneko S, Suzuki JI, Yoshida KI, Ono T. Intermittent hypoxia retards mandibular growth and alters RANKL expression in adolescent and juvenile rats. European Journal of Orthodontics. 2020.03; ( PubMed, DOI )

Tang H, Yonemitsu I, Ikeda Y, Watakabe K, Shibata S, Hosomichi J, Ono T. Effects of unilateral nasal obstruction on the characteristics of jaw-closing muscles in growing rats. The Angle Orthodontist. 2019.01; 89 (1): 102-110. ( PubMed, DOI )

Uchikawa Y, Hosomichi J, Suzuki JI, Yamaguchi H, Ishida Y, Hatano K, Usumi-Fujita R, Shimizu Y, Kaneko S, Uesugi S, Ono T.. Differential growth of craniofacial and tibial bones to sympathetic hyperactivity-related hypertension in rats. Archives of Oral Biology. 2019.01; 99 73-81. ( DOI )

Hosomichi J, Shibutani N, Yamaguchi H, Hatano K, Kuma Y, Suzuki T, Kaneko S, Ono T. Localization of leucine-rich repeat-containing G-protein-coupled receptor 5- and Ki67-positive periodontal cells expressing runt-related transcription factor 2 during tooth movement. Orthodontic Waves. 2018.12; 77 (4): 197-208. ( DOI )

Sato M, Asano T, Hosomichi J, Ono T, Nakata T. Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and biophysical research communications. 2018.10; 506 (3): 716-722.

Hatano K, Ishida Y, Yamaguchi H, Hosomichi J, Suzuki J, Usumi-Fujita R, Shimizu Y, Shibutani N, Kaneko S, Ono T. The chemokine receptor type 4 antagonist, AMD3100, interrupts experimental tooth movement in rats. Archives of Oral Biology. 2018.02; 86 35-39. ( PubMed, DOI )

Yamaguchi H, Ishida Y, Hosomichi J, Suzuki JI, Hatano K, Usumi-Fujita R, Shimizu Y, Kaneko S, Ono T. Ultrasound microbubble-mediated transfection of NF-κB decoy oligodeoxynucleotide into gingival tissues inhibits periodontitis in rats in vivo PLoS One. 2017.11; 1 (11): e0186264. ( PubMed, DOI )

Hosomichi J, Maeda H, Kuma Y, Oishi S, Yoshida KI, Ono T. . Differential effects of intermittent hypoxia on phenotypic and metabolic features of airway muscles in weaning- and adolescent-aged rats. Sleep Medicine. 2017.11; 40 e135. ( DOI )

Yamaguchi H, Ishida Y, Hosomichi J, Suzuki J, Usumi-Fujita R, Shimizu Y, Kaneko S, Ono T. A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method. Int J Oral Sci. 2017.06; 9 (2): 80-86. ( PubMed, DOI )

Kasahara Y, Usumi-Fujita R, Hosomichi J, Kaneko S, Ishida Y, Shibutani N, Shimizu Y, Okito O, Oishi S, Kuma Y, Yamaguchi H, Ono T. Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth. Angle Orthod. 2017.05; 87 (5): 709-716. ( PubMed, DOI )

Hosomichi J, Kuma Y, Oishi S, Nagai H, Maeda H, Usumi-Fujita R, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats. Am J Orthod Dentofacial Orthop. 2017.02; 151 (2): 363-371.

Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shibutani N , Suzuki J, Yoshida K, Ono T. Intermittent hypoxia Influences alveolar bone proper microstructure via hypoxia-inducible factor and VEGF expression in periodontal ligaments of growing rats. Front phsyiol. 2016.09; 7 Article 416.

Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology. Arch Oral Biol. 2016.01; 61 115-124. ( PubMed )

Park Y, Hosomichi J, Ge C, Xu J, Franceschi R, Kapila S. Immortalization and characterization of mouse temporomandibular joint disc cell clones with capacity for multi-lineage differentiation. Osteoarthr Cartil. 2015.09; 23 (9): 1532-1542. ( PubMed, DOI )

Kuma Y, Usumi-Fujita R, Hosomichi J, Oishi S, Maeda H, Nagai H, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T.. Impairment of nasal airway under intermittent hypoxia during growth period in rats. Arch Oral Biol. 2014.11; 59 (11): 1139-1145. ( PubMed, DOI )

Shimizu Y, Hosomichi J, Nakamura S, Ono T.. Micro-computed tomography analysis of changes in the periodontal ligament and alveolar bone proper induced by occlusal hypofunction of rat molars. Korean J Orthod. 2014.09; 44 (5): 263-267. ( PubMed, DOI )

Shitano C, Baba O, Kaneko S, Hosomichi J, Shimizu Y, Shibutani N, Usumi-Fujita R, Takano Y, Ono T.. Alveolar bone loss induced by the orthodontic tooth movement under hypofunctional conditions in rats. Orthodontic Waves. 2013.11; 72 (4): 148-155. ( DOI )

Shimizu Y, Ishida T, Hosomichi J, Kaneko S, Hatano K, Ono T.. Soft diet causes greater alveolar osteopenia in the mandible than in the maxilla. Arch Oral Biol. 2013.08; 58 (8): 907-911. ( PubMed, DOI )

Usumi-Fujita R, Hosomichi J, Ono N, Shibutani N, Kaneko S, Shimizu Y, Ono T.. Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement. Angle Orthod. 2013.01; 83 (1): 48-56. ( PubMed, DOI )

Kapila S, Park Y, Ahmad N, Hosomichi J, Hayami T, Tacon C.. Mechanisms for relaxin's modulation of MMPs and matrix loss in fibrocartilages. Ital J Anat Embryol. 2013; 118 (1 Suppl): 62-65. ( PubMed )

Yasuhiro Shimizu, Jun Hosomichi, Sawa Kaneko, Naoki Shibutani, Takashi Ono. Effect of sympathetic nervous activity on alveolar bone loss induced by occlusal hypofunction in rats. Arch. Oral Biol.. 2011.11; 56 (11): 1404-1411. ( PubMed, DOI )

Sako E, Hosomichi J.. Alteration of bFGF expression with growth and age in rat molar periodontal ligament. Angle Orthod. 2010.09; 80 (5): 904-911. ( PubMed, DOI )

Shibutani N, Hosomichi J, Ishida Y, Soma K.. Influence of occlusal stimuli on the microvasculature in rat dental pulp. Angle Orthod. 2010.03; 80 (2): 316-321. ( PubMed, DOI )

Wada H, Hosomichi J, Shimomoto Y, Soma K.. Influence of occlusal hypofunction on the elastic property and bone formation of rat alveolar bone. Orthodontic Waves. 2008.09; 67 (1): 9-14. ( DOI )

Termsuknirandorn S, Hosomichi J, Soma K.. Occlusal stimuli influence on the expression of IGF-1 and the IGF-1 receptor in the rat periodontal ligament. Angle Orthod. 2008.07; 78 (4): 610-616. ( PubMed, DOI )

Hu FW, Hosomichi J, Kanno Z, Soma K.. The influence of occlusal stimuli on basic fibroblast growth factor expression in the periodontal healing of replanted teeth. J Med Dent Sci. 2008.03; 55 (1): 129-135. ( PubMed )

Kishimoto G, Hosomichi J, Muramoto T, Kanno Z, Soma K.. Influence of estrogen cycle on temporomandibular joint synovial membrane in rat with deviated mandible. J Med Dent Sci. 2007.03; 54 (1): 79-85. ( PubMed )

Hosomichi J, Yasui N, Koide T, Soma K, Morita I.. Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor. Biochem Biophys Res Commun. 2005.09; 335 (3): 756-761. ( PubMed, DOI )

Sato M, Asano T, Hosomichi J, Nakata T, Ono T. Optogenetic manipulation of intracellular calcium by blue light-activated Ca2+ channel switch promotes osteogenic differentiation of MC3T3-E1 cells. 95th congress of the European Orthodontic Society 2019.06 Nice, France

Ongprakobkul N, Ishida Y, Hatano-sato K, Li K, Petdachai S, Hosomichi J, Mahatumarat K, Ono T . Effects of AMD3100 on Orthodontic Tooth Movement After Local/Systemic Administration. 2019 IADR/AADR/CADR General Session 2019.06 Vancouver, Canada

Torikai K, Kijima T, Kaida E, Nagaoka R, Shimazaki K. Long-term treatment results of bilateral cleft lip and palate treated by all-in-one repair. 76th ACPA's(American Cleft Palate Craniofacial association) Annual Meeting 2019.04 Arizona, USA

Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki J, Yoshida K, Ono T. β2-adrenergic antagonist butoxamine reduces the mandibular growth retardation caused by intermittent hypoxia in adolescent rats. The 77th Annual Meeting of the Japanese Orthodontic Society 2018.11.01 Yokomaha, Japan

Hong H, Hosomichi J, Maeda M, Lekvijittada K, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki JI, Yoshida KI, Ono T. Different effects of intermittent hypoxia on mandibular growth in the juvenile and adolescent rats. Wuhan University PhD seminar 2018.08.20 Wuhan, China

Uchikawa Y, Hosomichi J, Suzuki J, Yamaguchi H, Ishida Y, Hatano K, Usumi-Fujita R, Shimizu Y, Kaneko S, Uesugi S, Ono T. Differential growth response of craniofacial and limb bones to hypertension with sympathetic hyperactivity in rats. 96th General Session and Exhibition of the International Association for Dental Research (IADR) 2018.07.27 London, UK

Lekvijittada K, Hosomichi J, Maeda H, Hong H, Changsiripun C, Kuma Y, Oishi S, Suzuki J, Yoshida K, Ono T. Influence of intermittent hypoxia on condylar growth : A study in infant rats. The 11th Asian Pacific Orthodontic Conference 2018.03.25 Boracay, Republic of the Philippines

Hong H, Hosomichi J, Maeda H, Kochakorn L, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Suzuki J, Yoshida K, Ono T. The impact of a ß2-adrenergic antagonist, butoxamine on mandibular growth retardation caused by intermittent hypoxia in growing rats. The 11th Asian Pacific Orthodontic Conference 2018.03.05 Boracay, Republic of the Philippines

Lekvijittada K, Hosomichi J, Maeda H, Hong H, Changsiripun C, Kuma Y, Oishi S, Yamaguchi H, Ishida Y, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki JI, Yoshida KI, Ono T. Influences of intermittent hypoxia on condylar growth: A study in infant rats. 5th Tokyo Medical University Memorial Hall Poster Conference 2018.02.22 Tokyo, Japan

Hosomichi J, Maeda H, Kuma Y, Oishi S, Yoshida KI, Ono T. Differential effects of intermittent hypoxia on phenotypic and metabolic features of airway muscles in weaning- and adolescent-aged rats. 5th Tokyo Medical University Memorial Hall Poster Conference 2018.02.22 Tokyo, Japan

Hong H, Hosomichi J, Maeda H, Kochakorn L, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Suzuki J, Yoshida K, Ono T. The impact of a ß2-adrenergic antagonist, butoxamine on mandibular growth retardation caused by intermittent hypoxia in growing rats. 5th Tokyo Medical University Memorial Hall Poster Conference 2018.02.22 Tokyo, Japan

Hosomichi J, Maeda H, Yoichiro Kuma, Oishi S, Yoshida KI, Ono T. Differential effects of intermittent hypoxia on phenotypic and metabolic features of airway muscles in weaning- and adolescent-aged rats.. World Sleep 2017 2017.10.11 Prague, Czech Republic

Hiroyuki Yamaguchi, Yuji Ishida, Jun Hoshomichi, Jun-ichi Suzuki, Takashi Ono. Transfection of NF-κB decoy into the rodent periodontium using ultrasound-microbubble technique prevents the progression of the periodontitis. The 93rd congress of the European Orthodontic Society 2017.06.05 Montreux, Switzerland

Hosomichi J, Suzuki T, Shibutani N, Hatano K, Yamaguchi H, Kuma K, Kaneko S, Ono T. . Distribution of Ki67 and LGR5-positive Periodontal Cells During Tooth Movement. 2017 IADR/AADR/CADR General Session & Exhibition 2017.03.22 San Francisco, CA, USA

Oishi S, Shimizu Y, Hosomichi J, Kuma Y,　Usumi-Fujita R, Maeda H, Nagai H, Kaneko S, Shibutani N, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia influences bone microstructure via hypoxia inducible factor and VEGF in growing rats. The 10th Asia Pacific Orthodontic Conference 2016.09.01 Bali, Indonesia

Kasahara Y, Usumi-Fujita R, Hosomichi J, Kaneko S, Ishida Y, Shibutani N, Shimizu Y, Okito A, Oishi S, Kuma Y, Ono T. Effect of low-intensity pulsed ultrasound on periodontal tissues in occlusal hypofunctional teeth. The 38th Annual Scientific Conference on Dental Research 2016.04.04 Ho Chi Minh city, Vietnam

Hosomichi J, Nakai Y, Maeda H, Kuma Y, Oishi S, Usumi-Fujita R, Shimizu Y, Kaneko S, Ishida Y, Shibutani N, Yoshida K, Ono T. Intermittent hypoxia triggers inflammatory pathway with down-regulated myofibrillar and mitochondrial biogenesis in the geniohyoid muscle. The 74th Annual Meeting of the Japanese Orthodontic Society 2015.11.20 Fukuoka, Japan

Hosomichi J, Kuma Y, Oishi S, Usumi-Fujita R, Shimizu Y, Maeda H, Nagai H, Shitano C, Kaneko S, Ishida Y, Suzuki J, Yoshida K, Ono T. Up-regulation of inflammatory pathway through interleukins and NOS in the geniohyoid muscle. SLEEP 2015 2015.06.08 Seattle, WA, USA

Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Maeda H, Nagai H, Kaneko S, Suzuki J, Yoshida K, Ono T.. Disturbance of maxillofacial bone growth induced by intermittent hypoxia in growing rats.. 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP 2014) 2014.06.04 Minneapolis, MN, USA

Kuma Y, Usumi-Fujita R, Hosomichi J, Oishi S, Nagai H, Maeda H, Kaneko S, Suzuki J, Yoshida K, Ono T.. Growth impairment of nasal airway under intermittent hypoxia during growth period in rats.. 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP2014), 2014.05.31 Minneapolis

Hosomichi J, Oishi S, Kuma Y, Maeda H, Nagai H, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T.. Intermittent-hypoxia-induced expression of autophagy accelerates BNIP3 in the geniohyoid muscles in contrast to gastrocnemius muscle in rats.. 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP2014) 2014.05.29 Minneapolis, MN, USA

Kuma Y, Usumi-Fujita R, Hosomichi J, Oishi S, Nagai H, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T.. Impairment of nasal airway under intermittent hypoxia during growth period in rats.. The 36th Annual Scientific Conference on Dental Research 2014.03.31 Ho Chi Minh City, Vietnam

Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Maeda H, Nagai H, Kaneko S, Suzuki J, Yoshida K, Ono T.. The Intermittent hypoxia induced discrepancy of bone growth and density in rat maxillofacial bone.. The 36th Annual Scientific Conference on Dental Research 2014.03.31 Ho Chi Minh city, Vietnam

Shitano C, Baba O, Kaneko S, Hosomichi J, Shimizu Y, Shibutani N, Usumi-Fujita R, Takano Y, Ono T.. Alveolar bone loss induced by hypofunctional tooth movement in rats. . 2nd Meeting of the IADR Asia Pacific Region 2013.08.21 Bangkok, Tahiland

Hosomichi J, Park Y, Kapila S.. Immortalization and characterization of mouse temporomandibular joint disc cells. . 41 st Annual Meeting & Exhibition of the AADR, 36th Annual Meeting of the CADR 2012.03.22 Tampa, FL, USA

Shimizu Y, Hosomichi J, Kaneko S, Shibutani N, Ono T.. β-adrenergic receptor antagonist suppresses occlusal force unroading-induced alveolar bone loss in rats.. 2011 Annual Meeting of the American Society for Bone and Mineral Research 2011.09 San Diego, CA, USA

Hosomichi J, Park Y, Kapila S.. Immortalization and characterization of mouse temporomandibular joint (TMJ) disc cell clones.. The 2nd Asian Academic Congress for Temporomandibular Joint 2011.07.23 Hiroshima, JAPAN

Usumi R, Shibutani N, Ono N, Hosomichi J, Kaneko S, Ono T.. Occlusal stimuli influence VEGFR-2/CD31 expressions in periodontium during tooth movement.. The 89th General Session and Exhibition of IADR/AADR/CADR 2011.03.17 San Diego, CA, USA

Hu F, Hosomichi J, Kanno Z, Soma K.. Occlusal forces promote periodontal healing of transplanted teeth with enhanced basic fibroblast growth factor synthesis.. The 65th Annual Meeting of the Japanese Orthodontic Society and the 1st Joint Meeting of the Japanese Orthodontic Society and the Korea Association of Orthodontists 2006.09.15 Sapporo, JAPAN