Personnel Information

写真a

NISHINA Hiroshi


Job title

Professor

Laboratory Address

Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4659

Laboratory Fax number

+81-3-5803-5829

Mail Address

nishina.dbio@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/dbio/index.html#

Research Areas, Keywords

stress, signal transduction, JNK, Hippo, liver, development, regeneration, model organism, medaka

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Science, 1985, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Natural Science, Doctor's Course, 1990, Completed

Degree 【 display / non-display

  • Ph.D., The University of Tokyo

Campus Career 【 display / non-display

  • 2005.01
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Developmental and Regenerative Biology, Professor
  • 2005.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Developmental and Regenerative Biology, Professor

External Career 【 display / non-display

  • 2005.01
    -
    Now
    , Professor

Research Areas 【 display / non-display

  • Biological pharmacy

Qualification Acquired 【 display / non-display

  • Chief Person of Radiation Handling (first and second kind)

 

Research Theme 【 display / non-display

  • Studies on vertebrate early embryogenesis and developmental toxicity

  • Studies on vertebrate organogenesis

  • Studies on organ homeostasis

  • Studies on behavioral rhythm and locomotor activity

Published Papers & Misc 【 display / non-display

  • Jun Hirayama, Yikelamu Alifu, Rin Hamabe, Sho Yamaguchi, Jun Tomita, Yusuke Maruyama, Yoichi Asaoka, Ken-Ichi Nakahama, Teruya Tamaru, Ken Takamatsu, Nobuhiko Takamatsu, Atsuhiko Hattori, Sachiko Nishina, Noriyuki Azuma, Atsuo Kawahara, Kazuhiko Kume, Hiroshi Nishina. The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Sci Rep. 2019.01; 9 (1): 196. ( PubMed, DOI )

  • Miki Nishio, Yousuke Miyachi, Junji Otani, Shoji Tane, Hirofumi Omori, Fumihito Ueda, Hideru Togashi, Takehiko Sasaki, Tak Wah Mak, Kazuwa Nakao, Yasuyuki Fujita, Hiroshi Nishina, Tomohiko Maehama, Akira Suzuki. Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. FASEB J.. 2019.01; fj201802005R. ( PubMed, DOI )

  • Takuro Nagoya, Kenya Kamimura, Ryo Goto, Yoko Shinagawa-Kobayashi, Yusuke Niwa, Atsushi Kimura, Norihiro Sakai, Masayoshi Ko, Hiroshi Nishina, Shuji Terai. Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. FEBS Open Bio. 2019.12; 9 (12): 2016-2024. ( PubMed, DOI )

  • Ryo Goto, Kenya Kamimura, Yoko Shinagawa-Kobayashi, Norihiro Sakai, Takuro Nagoya, Yusuke Niwa, Masayoshi Ko, Kohei Ogawa, Ryosuke Inoue, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Abe, Hiroshi Nishina, Shuji Terai. Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH). FEBS Open Bio. 2019.12; 9 (4): 643-652. ( PubMed, DOI )

  • Asami Kawasaki, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi. Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration. iScience. 2018.06; 4 190-203. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hiroshi Nishina. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis . 6th Asian Oceania Zebrafish PI’s Meeting (AOZM), Hong Kong, USA 2013.07.19

  • 仁科博史. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis. 熊本大学HIGO Program 2012.02.12

 

Campus class subject 【 display / non-display

  • Development and Regenerative Bioscience,2014 - Now

  • Bioscience II,2013 - Now

  • Molecular Cell Biology

  • Methods for studying the development