Personnel Information

写真a

NISHINA Hiroshi


Job title

Professor

Laboratory Address

Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4659

Laboratory Fax number

+81-3-5803-5829

Mail Address

nishina.dbio@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/dbio/index.html#

Research Areas, Keywords

stress, signal transduction, JNK, Hippo, liver, development, regeneration, model organism, medaka

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Science, 1985, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Natural Science, Doctor's Course, 1990, Completed

Degree 【 display / non-display

  • Ph.D., The University of Tokyo

Campus Career 【 display / non-display

  • 2005.01
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Developmental and Regenerative Biology, Professor
  • 2005.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Developmental and Regenerative Biology, Professor

External Career 【 display / non-display

  • 2005.01
    -
    Now
    , Professor

Research Areas 【 display / non-display

  • Biological pharmacy

Qualification Acquired 【 display / non-display

  • Chief Person of Radiation Handling (first and second kind)

 

Research Theme 【 display / non-display

  • Studies on vertebrate early embryogenesis and developmental toxicity

  • Studies on vertebrate organogenesis

  • Studies on organ homeostasis

  • Studies on behavioral rhythm and locomotor activity

Published Papers & Misc 【 display / non-display

  • Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed, DOI )

  • Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina. Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells. 2020.03; 25 (3): 197-214. ( PubMed, DOI )

  • Hirofumi Omori, Miki Nishio, Muneyuki Masuda, Yosuke Miyachi, Fumihito Ueda, Takafumi Nakano, Kuniaki Sato, Koshi Mimori, Kenichi Taguchi, Hiroki Hikasa, Hiroshi Nishina, Hironori Tashiro, Tohru Kiyono, Tak Wah Mak, Kazuwa Nakao, Takashi Nakagawa, Tomohiko Maehama, Akira Suzuki. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv. 2020; 6 (12): eaay3324. ( PubMed, DOI )

  • Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzuki, Josef M Penninger, Hiroshi Nishina, Yuji Nishikawa. Hepatocyte MKK7 Contributes to Restoration of the Liver Parenchyma Following Injury. Hepatology. 2020.09; ( PubMed, DOI )

  • Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hata. The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. J. Biol. Chem.. 2020.08; 295 (32): 11214-11230. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hiroshi Nishina. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis . 6th Asian Oceania Zebrafish PI’s Meeting (AOZM), Hong Kong, USA 2013.07.19

  • 仁科博史. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis. 熊本大学HIGO Program 2012.02.12

 

Campus class subject 【 display / non-display

  • Development and Regenerative Bioscience,2014 - Now

  • Bioscience II,2013 - Now

  • Methods for studying the development

  • Molecular Cell Biology