Personnel Information

写真a

NISHINA Hiroshi


Job title

Professor

Laboratory Address

Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4659

Laboratory Fax number

+81-3-5803-5829

Mail Address

nishina.dbio@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/dbio/index.html#

Research Areas, Keywords

stress, signal transduction, JNK, Hippo, liver, development, regeneration, model organism, medaka
To the head of this page.▲

Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Science, 1985, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Natural Science, Doctor's Course, 1990, Completed

To the head of this page.▲

Degree 【 display / non-display 】

  • Ph.D., The University of Tokyo

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2005.01
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Developmental and Regenerative Biology， Professor
  • 2005.01
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Developmental and Regenerative Biology， Professor
  • 2020.04
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Director
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Developmental and Regenerative Biology， Professor
To the head of this page.▲

External Career 【 display / non-display 】

  • 2005.01
    -
    Now
    , Professor
To the head of this page.▲

Research Areas 【 display / non-display 】

  • Pharmaceutical hygiene and biochemistry

To the head of this page.▲

Qualification Acquired 【 display / non-display 】

  • Chief Person of Radiation Handling （first and second kind）

To the head of this page.▲
 

Published Papers & Misc 【 display / non-display 】

  1. Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki. Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl Acad Sci U S A. 2022.07; 119 (29): e2123134119. ( PubMed, DOI )

  2. Joshua Agbemefa Kuleape, Shakhawoat Hossain, Caleb Kwame Sinclear, Takanobu Shimizu, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata. DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription. Mol Cell Biol. 2022.02; 42 (2): e0031021. ( PubMed, DOI )

  3. Mayu Morishita, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Kyohei Niimura, Hiroaki Iwasa, Junichi Maruyama, Yuichi Hiraoka, Kohei Yamamoto, Masanobu Kitagawa, Norio Miyamura, Hiroshi Nishina, Yutaka Hata. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling. Genes Cells. 2021.12; 26 (12): 999-1013. ( PubMed, DOI )

  4. Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Junji Otani, Keiko Yamaguchi, Miki Fukumoto, Hiroki Hikasa, Shinji Hagiwara, Hiroshi Nishina, Tak Wah Mak, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akira Suzuki. Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer Sci. 2021.10; 112 (10): 4303-4316. ( PubMed, DOI )

  5. Sachi Sunaga, Satoshi Kofuji, Hiroshi Nishina. YAP drives cell competition by activating choline metabolism. Biochem Biophys Res Commun. 2021.10; 572 178-184. ( PubMed, DOI )

  6. Shunta Nagashima, Junichi Maruyama, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Makiko Nawa, Ken-Ichi Nakahama, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruhiko Sugimura, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata. CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. J Biol Chem. 2021.07; 297 (1): 100803. ( PubMed, DOI )

  7. Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzuki, Josef M Penninger, Hiroshi Nishina, Yuji Nishikawa. Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice. Hepatology. 2021.06; 73 (6): 2510-2526. ( PubMed, DOI )

  8. Xinliang Jiang, Junichi Maruyama, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata. Heat shock induces the nuclear accumulation of YAP1 via SRC. Exp Cell Res. 2021.02; 399 (1): 112439. ( PubMed, DOI )

  9. Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed, DOI )

  10. Yikelamu Alifu, Satoshi Kofuji, Sachi Sunaga, Mizuki Kusaba, Jun Hirayama, Hiroshi Nishina. The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish. Biol Pharm Bull. 2021; 44 (8): 1160-1165. ( PubMed, DOI )

  11. Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina. Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells. 2020.03; 25 (3): 197-214. ( PubMed, DOI )

  12. Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto-Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata. Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling. Cancer Sci. 2022.04; 113 (4): 1305-1320. ( PubMed, DOI )

  13. Hirofumi Omori, Miki Nishio, Muneyuki Masuda, Yosuke Miyachi, Fumihito Ueda, Takafumi Nakano, Kuniaki Sato, Koshi Mimori, Kenichi Taguchi, Hiroki Hikasa, Hiroshi Nishina, Hironori Tashiro, Tohru Kiyono, Tak Wah Mak, Kazuwa Nakao, Takashi Nakagawa, Tomohiko Maehama, Akira Suzuki. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv. 2020; 6 (12): eaay3324. ( PubMed, DOI )

  14. Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hata. The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. J. Biol. Chem.. 2020.08; 295 (32): 11214-11230. ( PubMed, DOI )

  15. Miki Nishio, Yoko To, Tomohiko Maehama, Yukari Aono, Junji Otani, Hiroki Hikasa, Akihiro Kitagawa, Koshi Mimori, Takehiko Sasaki, Hiroshi Nishina, Shinya Toyokuni, John P Lydon, Kazuwa Nakao, Tak Wah Mak, Tohru Kiyono, Hidetaka Katabuchi, Hironori Tashiro, Akira Suzuki. Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer Sci.. 2020.07; 111 (10): 3576-3587. ( PubMed, DOI )

  16. Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Norihiro Sakai, Takuro Nagoya, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Akira Sakamaki, Hiroteru Kamimura, Norio Miyamura, Hiroshi Nishina, Shuji Terai. Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. Cancers (Basel). 2020.02; 12 (2): ( PubMed, DOI )

  17. Nozomi Hanzawa, Koshi Hashimoto, Xunmei Yuan, Kenichi Kawahori, Kazutaka Tsujimoto, Miho Hamaguchi, Toshiya Tanaka, Yuya Nagaoka, Hiroshi Nishina, Sumiyo Morita, Izuho Hatada, Tetsuya Yamada, Yoshihiro Ogawa. Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. Sci Rep. 2020; 10 (1): 5181. ( PubMed, DOI )

  18. Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS ONE. 2020; 15 (4): e0231265. ( PubMed, DOI )

  19. Takuro Nagoya, Kenya Kamimura, Ryo Goto, Yoko Shinagawa-Kobayashi, Yusuke Niwa, Atsushi Kimura, Norihiro Sakai, Masayoshi Ko, Hiroshi Nishina, Shuji Terai. Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. FEBS Open Bio. 2019.12; 9 (12): 2016-2024. ( PubMed, DOI )

  20. Jun Hirayama, Yikelamu Alifu, Rin Hamabe, Sho Yamaguchi, Jun Tomita, Yusuke Maruyama, Yoichi Asaoka, Ken-Ichi Nakahama, Teruya Tamaru, Ken Takamatsu, Nobuhiko Takamatsu, Atsuhiko Hattori, Sachiko Nishina, Noriyuki Azuma, Atsuo Kawahara, Kazuhiko Kume, Hiroshi Nishina. The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Sci Rep. 2019.01; 9 (1): 196. ( PubMed, DOI )

  21. Miki Nishio, Yousuke Miyachi, Junji Otani, Shoji Tane, Hirofumi Omori, Fumihito Ueda, Hideru Togashi, Takehiko Sasaki, Tak Wah Mak, Kazuwa Nakao, Yasuyuki Fujita, Hiroshi Nishina, Tomohiko Maehama, Akira Suzuki. Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. FASEB J.. 2019.01; 33 (4): fj201802005R. ( PubMed, DOI )

  22. Ryo Goto, Kenya Kamimura, Yoko Shinagawa-Kobayashi, Norihiro Sakai, Takuro Nagoya, Yusuke Niwa, Masayoshi Ko, Kohei Ogawa, Ryosuke Inoue, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Abe, Hiroshi Nishina, Shuji Terai. Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH). FEBS Open Bio. 2019.12; 9 (4): 643-652. ( PubMed, DOI )

  23. Asami Kawasaki, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi. Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration. iScience. 2018.06; 4 190-203. ( PubMed, DOI )

  24. K Otsubo, H Goto, M Nishio, K Kawamura, S Yanagi, W Nishie, T Sasaki, T Maehama, H Nishina, K Mimori, T Nakano, H Shimizu, T W Mak, K Nakao, Y Nakanishi, A Suzuki. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017.07; 36 (29): 4201-4211. ( PubMed, DOI )

  25. Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina. YAP determines the cell fate of injured mouse hepatocytes in vivo. Nat Commun. 2017.07; 8 16017. ( PubMed, DOI )

  26. Erika Ishihara, Hiroshi Nishina. The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis. Cancers (Basel). 2018.04; 10 (4): ( PubMed, DOI )

  27. Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M Penninger, Shigenobu Shibata, Hiroshi Nishina. Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 2017.08; 7 (1): 7348. ( PubMed, DOI )

  28. Seiichiro Mori, Takamasa Takeuchi, Yoshiyuki Ishii, Takashi Yugawa, Tohru Kiyono, Hiroshi Nishina, Iwao Kukimoto. Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J. Virol.. 2017.03; 91 (6): ( PubMed, DOI )

  29. Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-Ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi. Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 2017.11; 8 (1): 1246. ( PubMed, DOI )

  30. Jun Negishi, Yuka Omori, Mami Shindo, Hayate Takanashi, Shiori Musha, Suminori Nagayama, Jun Hirayama, Hiroshi Nishina, Takashi Nakakura, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Yuta Mochimaru, Hideaki Tomura. Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4. J. Recept. Signal Transduct. Res.. 2017.08; 37 (4): 401-408. ( PubMed, DOI )

  31. Yoichi Asaoka, Hiroshi Nishina, Makoto Furutani-Seiki. YAP is essential for 3D organogenesis withstanding gravity. Dev. Growth Differ.. 2017.01; 59 (1): 52-58. ( PubMed, DOI )

  32. Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M Penninger, Sachiko Nishina, Noriyuki Azuma, Hiroshi Nishina. The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 2016.11; 6 37697. ( PubMed, DOI )

  33. Takanori Chiba, Erika Ishihara, Norio Miyamura, Rika Narumi, Mihoko Kajita, Yasuyuki Fujita, Akira Suzuki, Yoshihiro Ogawa, Hiroshi Nishina. MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Sci Rep. 2016.06; 6 28383. ( PubMed, DOI )

  34. Yoichi Asaoka, Yoko Nagai, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina. SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling. Biochem. Biophys. Res. Commun.. 2016.05; 474 (1): 146-153. ( PubMed, DOI )

  35. Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata. Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer Sci.. 2016.06; 107 (6): 791-802. ( PubMed, DOI )

  36. Koichi Fujisawa, Shuji Terai, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki, Toshihiko Matsumoto, Kazuhito Yamaguchi, Yuji Owada, Hiroshi Nishina, Takafumi Noma, Isao Sakaida. Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. J. Exp. Clin. Cancer Res.. 2016.03; 35 48. ( PubMed, DOI )

  37. Yusuke Nasu, Yoichi Asaoka, Misako Namae, Hiroshi Nishina, Hideaki Yoshimura, Takeaki Ozawa. Genetically Encoded Fluorescent Probe for Imaging Apoptosis in Vivo with Spontaneous GFP Complementation. Anal. Chem.. 2016.01; 88 (1): 838-844. ( PubMed, DOI )

  38. Miki Nishio, Keishi Sugimachi, Hiroki Goto, Jia Wang, Takumi Morikawa, Yosuke Miyachi, Yusuke Takano, Hiroki Hikasa, Tohru Itoh, Satoshi O Suzuki, Hiroki Kurihara, Shinichi Aishima, Andrew Leask, Takehiko Sasaki, Toru Nakano, Hiroshi Nishina, Yuji Nishikawa, Yoshitaka Sekido, Kazuwa Nakao, Kazuo Shin-Ya, Koshi Mimori, Akira Suzuki. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc. Natl. Acad. Sci. U.S.A.. 2016.01; 113 (1): E71-E80. ( PubMed, DOI )

  39. Sean Porazinski, Huijia Wang, Yoichi Asaoka, Martin Behrndt, Tatsuo Miyamoto, Hitoshi Morita, Shoji Hata, Takashi Sasaki, S.F. Gabby Krens, Yumi Osada, Satoshi Asaka, Akihiro Momoi, Sarah Linton, Joel B. Miesfeld, Brian A. Link, Takeshi Senga, Atahualpa Castillo-Morales, Araxi O. Urrutia, Nobuyoshi Shimizu, Hideaki Nagase, Shinya Matsuura, Stefan Bagby, Hisato Kondoh, Hiroshi Nishina, Carl-Philipp Heisenberg and Makoto Furutani-Seiki. YAP is essential for tissue tension to ensure vertebrate 3D body shape Nature. 2015.04;

  40. Ruoxing Yu, Norio Miyamura, Yoshimi Okamoto-Uchida, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina. A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis. PLoS ONE. 2015.12; 10 (12): e0145286. ( PubMed, DOI )

  41. Koichi Fujisawa, Shuji Terai, Toshihiko Matsumoto, Taro Takami, Naoki Yamamoto, Hiroshi Nishina, Makoto Furutani-Seiki, Isao Sakaida. Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. PLoS ONE. 2015.02; 10 (6): e0129950. ( PubMed, DOI )

  42. Shodai Kawano, Junichi Maruyama, Shunta Nagashima, Kazutoshi Inami, Wenzhe Qiu, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata. A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells. J. Biochem.. 2015.11; 158 (5): 413-423. ( PubMed, DOI )

  43. Yuta Mochimaru, Morio Azuma, Natsuki Oshima, Yuta Ichijo, Kazuhiro Satou, Kouhei Matsuda, Yoichi Asaoka, Hiroshi Nishina, Takashi Nakakura, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Hideaki Tomura. Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish. Biochem. Biophys. Res. Commun.. 2015.02; 457 (4): 493-499. ( PubMed, DOI )

  44. Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed, DOI )

  45. Noriyuki Azuma, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Miho Terao, Shuji Takada, Maki Fukami, Kohji Okamura, Kayoko Maehara, Tokiwa Yamasaki, Jun Hirayama, Hiroshi Nishina, Hiroshi Handa, Yuki Yamaguchi. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Hum Mol Genet. 2023.06; 32 (12): 2032-2045. ( PubMed, DOI )

  46. Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Kofuji, Toshifumi Wakai, Hiroshi Nishina, Shuji Terai. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochem Biophys Rep. 2022.12; 32 101352. ( PubMed, DOI )

  47. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed, DOI )

  48. Hiroshi Nishina. Physiological and pathological roles of the Hippo-YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis. Cancer Sci. 2022.06; 113 (6): 1900-1908. ( PubMed, DOI )

  49. Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Sci Rep. 2022.05; 12 (1): 7312. ( PubMed, DOI )

  50. Sinclear Caleb Kwame, Maruyama Junichi, Nagashima Shunta, Arimoto-Matsuzaki Kyoko, Kuleape Joshua Agbemefa, Iwasa Hiroaki, Nishina Hiroshi, Hata Yutaka. Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling(和訳中) Cancer Science. 2022.04; 113 (4): 1305-1320. ( ichushi )

  51. Shoko Miyata, Noriaki Saku, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Kei Yura, Tohru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa. Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI). Stem Cell Res Ther. 2022.01; 13 (1): 6. ( PubMed, DOI )

  52. Nakatani Keisuke, Maehama Tomohiko, Nishio Miki, Otani Junji, Yamaguchi Keiko, Fukumoto Miki, Hikasa Hiroki, Hagiwara Shinji, Nishina Hiroshi, Mak Tak Wah, Honma Teruki, Kondoh Yasumitsu, Osada Hiroyuki, Yoshida Minoru, Suzuki Akira. アラントラクトンは活性酸素種の蓄積を促進することによりYAP1/TAZを強力に阻害する天然物である(Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation) Cancer Science. 2021.10; 112 (10): 4303-4316. ( ichushi )

  53. Alifu Yikelamu, Kofuji Satoshi, Sunaga Sachi, Kusaba Mizuki, Hirayama Jun, Nishina Hiroshi. ゼブラフィッシュにおいて光作動性遺伝子Per2、Cry1aおよびCry2aは酸化状態を調節する(The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish) Biological & Pharmaceutical Bulletin. 2021.08; 44 (8): 1160-1165. ( ichushi )

  54. Nishio Miki, To Yoko, Maehama Tomohiko, Aono Yukari, Otani Junji, Hikasa Hiroki, Kitagawa Akihiro, Mimori Koshi, Sasaki Takehiko, Nishina Hiroshi, Toyokuni Shinya, Lydon John P., Nakao Kazuwa, Mak Tak Wah, Kiyono Tohru, Katabuchi Hidetaka, Tashiro Hironori, Suzuki Akira. 内因性YAP1の活性化はマウスにおいて子宮頸部上皮内癌の即時発症を惹起させる(Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice) Cancer Science. 2020.10; 111 (10): 3576-3587. ( ichushi )

  55. Hiroki Goto, Miki Nishio, Yoko To, Tatsuya Oishi, Yosuke Miyachi, Tomohiko Maehama, Hiroshi Nishina, Haruhiko Akiyama, Tak Wah Mak, Yuma Makii, Taku Saito, Akihiro Yasoda, Noriyuki Tsumaki, Akira Suzuki. in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9. Development. 2018; 145 (6): ( PubMed, DOI )

  56. Asaoka Yoichi, Nishina Hiroshi, Furutani-Seiki Makoto. 【発生時のサイズ】YAPは重力に抵抗性の3D器官形成にとって必須である(【Size in development】YAP is essential for 3D organogenesis withstanding gravity) Development, Growth & Differentiation. 2017.01; 59 (1): 52-58. ( ichushi )

  57. Shuji Terai, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Tsuyoshi Ishikawa, Yohei Urata, Haruko Tanimoto, Takuya Iwamoto, Yuko Mizunaga, Takashi Matsuda, Takashi Oono, Miho Marumoto, Guzel Burganova, Luiz Fernando Quintanilha, Isao Hidaka, Yoshio Marumoto, Issei Saeki, Koichi Uchida, Takahiro Yamasaki, Kenji Tani, Yasuho Taura, Yasuhiko Fujii, Hiroshi Nishina, Kiwamu Okita, Isao Sakaida. Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells. Tissue Eng Part B Rev. 2014.06; 20 (3): 206-210. ( PubMed, DOI )

  58. Zeyu Yang, Kentaro Nakagawa, Aradhan Sarkar, Junichi Maruyama, Hiroaki Iwasa, Yijun Bao, Mari Ishigami-Yuasa, Shigeru Ito, Hiroyuki Kagechika, Shoji Hata, Hiroshi Nishina, Shinya Abe, Masanobu Kitagawa, Yutaka Hata. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol. Cell. Biol.. 2014.05; 34 (9): 1607-1621. ( PubMed, DOI )

  59. Keita Nakanaga, Kotaro Hama, Kuniyuki Kano, Takanao Sato, Hiroshi Yukiura, Asuka Inoue, Daisuke Saigusa, Hidetoshi Tokuyama, Yoshihisa Tomioka, Hiroshi Nishina, Atsuo Kawahara, Junken Aoki. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. J. Biochem.. 2014.04; 155 (4): 235-241. ( PubMed, DOI )

  60. Tadanori Shimomura, Norio Miyamura, Shoji Hata, Ryota Miura, Jun Hirayama, Hiroshi Nishina. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun.. 2014.01; 443 (3): 917-923. ( PubMed, DOI )

  61. Yoichi Asaoka, Shoji Hata, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014; 9 (5): e97365. ( PubMed, DOI )

  62. Menno J Oudhoff, Spencer A Freeman, Amber L Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H Min, Jeffrey P Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Hiroshi Nishina, Michael R Gold, Fabio M V Rossi, Anne-Claude Gingras, Colby Zaph. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev. Cell. 2013.07; 26 (2): 188-194. ( PubMed, DOI )

  63. Yoichi Asaoka, Shuji Terai, Isao Sakaida, Hiroshi Nishina. The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis Model Mech. 2013.07; 6 (4): 905-914. ( PubMed, DOI )

  64. Norie Arima, Yoshimi Uchida, Ruoxing Yu, Koh Nakayama, Hiroshi Nishina. Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem. Biophys. Res. Commun.. 2013.06; 435 (3): 447-453. ( PubMed, DOI )

  65. Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W Mak, Toru Nakano, Satoshi Itami, Akira Suzuki. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest.. 2012.12; 122 (12): 4505-4518. ( PubMed, DOI )

  66. Hiroshi Nishina. hDlk-1: a cell surface marker common to normal hepatic stem/progenitor cells and carcinomas. J. Biochem.. 2012.08; 152 (2): 121-123. ( PubMed, DOI )

  67. Shoji Hata, Jun Hirayama, Hiroaki Kajiho, Kentaro Nakagawa, Yutaka Hata, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem.. 2012.06; 287 (26): 22089-22098. ( PubMed, DOI )

  68. Ken Okada, Akihide Kamiya, Keiichi Ito, Ayaka Yanagida, Hidenori Ito, Hiroki Kondou, Hiroshi Nishina, Hiromitsu Nakauchi. Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells Dev.. 2012.05; 21 (7): 1124-1133. ( PubMed, DOI )

  69. Toshiyuki Oishi, Shuji Terai, Shinya Kuwashiro, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida. Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Biochem. Biophys. Res. Commun.. 2012.05; 422 (1): 22-27. ( PubMed, DOI )

  70. Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, Hiroshi Nishina. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. J. Biol. Chem.. 2012.03; 287 (11): 8318-8326. ( PubMed, DOI )

  71. Takuya Iwamoto, Shuji Terai, Yuko Mizunaga, Naoki Yamamoto, Kaoru Omori, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Hiroshi Nishina, Isao Sakaida. Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients. J. Gastroenterol.. 2012.03; 47 (3): 300-312. ( PubMed, DOI )

  72. Tadashi Yokoi, Yuko Seko, Tae Yokoi, Hatsune Makino, Shin Hatou, Masakazu Yamada, Tohru Kiyono, Akihiro Umezawa, Hiroshi Nishina, Noriyuki Azuma. Establishment of functioning human corneal endothelial cell line with high growth potential. PLoS ONE. 2012; 7 (1): e29677. ( PubMed, DOI )

  73. Yuko Mizunaga, Shuji Terai, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Yusuke Fujita, Koh Shinoda, Yoshihiko Hamamoto, Isao Sakaida. Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice. Cell Transplant. 2012; 21 (11): 2363-2375. ( PubMed, DOI )

  74. Tokiwa Yamasaki, Hiroshi Kawasaki, Hiroshi Nishina. Diverse Roles of JNK and MKK Pathways in the Brain. J Signal Transduct. 2012; 2012 459265. ( PubMed, DOI )

  75. Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina, Junken Aoki. Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J. Biol. Chem.. 2011.12; 286 (51): 43972-43983. ( PubMed, DOI )

  76. Tokiwa Yamasaki, Hiroshi Kawasaki, Satoko Arakawa, Kimiko Shimizu, Shigeomi Shimizu, Orly Reiner, Hideyuki Okano, Sachiko Nishina, Noriyuki Azuma, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina. Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J. Neurosci.. 2011.11; 31 (46): 16872-16883. ( PubMed, DOI )

  77. Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Tomoaki Murata, Toshifumi Matsuyama, Hiroshi Nishina, Isao Sakaida. TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion. Cell Tissue Res.. 2011.10; 346 (1): 79-88. ( PubMed, DOI )

  78. Yijun Bao, Kentaro Nakagawa, Zeyu Yang, Mitsunobu Ikeda, Kanchanamala Withanage, Mari Ishigami-Yuasa, Yukiko Okuno, Shoji Hata, Hiroshi Nishina, Yutaka Hata. A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J. Biochem.. 2011.08; 150 (2): 199-208. ( PubMed, DOI )

  79. S Takahashi, A Ebihara, H Kajiho, K Kontani, H Nishina, T Katada. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. Cell Death Differ.. 2011.04; 18 (4): 645-655. ( PubMed, DOI )

  80. Shinya Kuwashiro, Shuji Terai, Toshiyuki Oishi, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida. Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res.. 2011.04; 344 (1): 125-134. ( PubMed, DOI )

  81. Shinya Takahashi, Kyoko Sakurai, Arisa Ebihara, Hiroaki Kajiho, Kota Saito, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada. RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic Acids Res.. 2011.04; 39 (8): 3446-3457. ( PubMed, DOI )

  82. Norio Miyamura, Takashi Nakamura, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Tokiwa Yamasaki, Shuji Terai, Isao Sakaida, Mitsutoshi Setou, Hiroshi Nishina. Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver. Biochem. Biophys. Res. Commun.. 2011.04; 408 (1): 120-125. ( PubMed, DOI )

  83. Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol. Pharm. Bull.. 2011; 34 (8): 1343-1347. ( PubMed )

  84. Jinzhan Wu, Junko Kubota, Jun Hirayama, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina. p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev.. 2010.11; 19 (11): 1723-1734. ( PubMed, DOI )

  85. Yoichi Asaoka, Hiroshi Nishina. Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J. Biochem.. 2010.10; 148 (4): 393-401. ( PubMed, DOI )

  86. Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, Yuji Yamanashi. Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab. Invest.. 2010.09; 90 (9): 1357-1364. ( PubMed, DOI )

  87. Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida. Medaka as a model for human nonalcoholic steatohepatitis. Dis Model Mech. 2010.07; 3 (7-8): 431-440. ( PubMed, DOI )

  88. Masahiko Tanaka, Hideyuki Hara, Hiroshi Nishina, Kentaro Hanada, Ken'ichi Hagiwara, Tomohiko Maehama. An improved method for cell-to-cell transmission of infectious prion. Biochem. Biophys. Res. Commun.. 2010.07; 397 (3): 505-508. ( PubMed, DOI )

  89. Jungwon Seo, Yoichi Asaoka, Yoko Nagai, Jun Hirayama, Tokiwa Yamasaki, Misako Namae, Shinya Ohata, Nao Shimizu, Takahiro Negishi, Daiju Kitagawa, Hisato Kondoh, Makoto Furutani-Seiki, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J. Cell. Biochem.. 2010.07; 110 (4): 1022-1037. ( PubMed, DOI )

  90. Yoko Nagai, Yoichi Asaoka, Misako Namae, Kota Saito, Haruka Momose, Hiroshi Mitani, Makoto Furutani-Seiki, Toshiaki Katada, Hiroshi Nishina. The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem. Biophys. Res. Commun.. 2010.06; 396 (4): 887-893. ( PubMed, DOI )

  91. G Gregory Neely, Keiji Kuba, Anthony Cammarato, Kazuya Isobe, Sabine Amann, Liyong Zhang, Mitsushige Murata, Lisa Elmén, Vaijayanti Gupta, Suchir Arora, Rinku Sarangi, Debasis Dan, Susumu Fujisawa, Takako Usami, Cui-ping Xia, Alex C Keene, Nakissa N Alayari, Hiroyuki Yamakawa, Ulrich Elling, Christian Berger, Maria Novatchkova, Rubina Koglgruber, Keiichi Fukuda, Hiroshi Nishina, Mitsuaki Isobe, J Andrew Pospisilik, Yumiko Imai, Arne Pfeufer, Andrew A Hicks, Peter P Pramstaller, Sai Subramaniam, Akinori Kimura, Karen Ocorr, Rolf Bodmer, Josef M Penninger. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010.04; 141 (1): 142-153. ( PubMed, DOI )

  92. Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem. J.. 2010.04; 427 (2): 237-245. ( PubMed, DOI )

  93. S Shimizu, A Konishi, Y Nishida, T Mizuta, H Nishina, A Yamamoto, Y Tsujimoto. Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010.04; 29 (14): 2070-2082. ( PubMed, DOI )

  94. Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology. 2010.03; 51 (3): 1037-1045. ( PubMed, DOI )

  95. Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol. Pharm. Bull.. 2010; 33 (4): 535-544. ( PubMed )

  96. Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina. CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochem. Biophys. Res. Commun.. 2009.12; 390 (4): 1129-1135. ( PubMed, DOI )

  97. Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina. Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009.09; 8 (17): 2794-2801. ( PubMed )

  98. Takashi Nakamura, Hiroshi Nishina. Liver development: lessons from knockout mice and mutant fish. Hepatol. Res.. 2009.07; 39 (7): 633-644. ( PubMed, DOI )

  99. Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina. CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. Biol. Pharm. Bull.. 2009.07; 32 (7): 1183-1187. ( PubMed )

  100. Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina. Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol. Pharm. Bull.. 2009.06; 32 (6): 999-1003. ( PubMed )

  101. Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina. Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J. Biochem.. 2009.03; 145 (3): 345-354. ( PubMed, DOI )

  102. Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina. Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2009.02; 379 (4): 817-823. ( PubMed, DOI )

  103. Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura, Hiroshi Mitani. Medaka: a promising model animal for comparative population genomics. BMC Res Notes. 2009; 2 88. ( PubMed, DOI )

  104. Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, Kentaro Hanada. RalA functions as an indispensable signal mediator for the nutrient-sensing system. J. Biol. Chem.. 2008.12; 283 (50): 35053-35059. ( PubMed, DOI )

  105. Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-Ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada. Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA. 2008.09; 14 (9): 1950-1958. ( PubMed, DOI )

  106. Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura. Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. Biochem. Biophys. Res. Commun.. 2008.07; 371 (4): 639-643. ( PubMed, DOI )

  107. Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida. Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem. Biophys. Res. Commun.. 2008.03; 367 (3): 546-552. ( PubMed, DOI )

  108. T Wada, E Stepniak, L Hui, A Leibbrandt, T Katada, H Nishina, E F Wagner, J M Penninger. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ.. 2008.01; 15 (1): 89-93. ( PubMed, DOI )

  109. Takashi Nakamura, Yuuki Imai, Takahiro Matsumoto, Shingo Sato, Kazusane Takeuchi, Katsuhide Igarashi, Yoshifumi Harada, Yoshiaki Azuma, Andree Krust, Yoko Yamamoto, Hiroshi Nishina, Shu Takeda, Hiroshi Takayanagi, Daniel Metzger, Jun Kanno, Kunio Takaoka, T John Martin, Pierre Chambon, Shigeaki Kato. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007.09; 130 (5): 811-823. ( PubMed, DOI )

  110. Seiji Ura, Hiroshi Nishina, Yukiko Gotoh, Toshiaki Katada. Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol. Cell. Biol.. 2007.08; 27 (15): 5514-5522. ( PubMed, DOI )

  111. Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res.. 2007.03; 327 (3): 463-470. ( PubMed, DOI )

  112. Shoji Hata, Misako Namae, Hiroshi Nishina. Liver development and regeneration: from laboratory study to clinical therapy. Dev. Growth Differ.. 2007.02; 49 (2): 163-170. ( PubMed, DOI )

  113. Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, Hiroshi Nishina. Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J.. 2006.07; 25 (14): 3286-3297. ( PubMed, DOI )

  114. Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida. Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. Proteomics. 2006.04; 6 (8): 2564-2570. ( PubMed, DOI )

  115. Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, Kiwamu Okita. Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res.. 2006.02; 323 (2): 221-231. ( PubMed, DOI )

  116. Teiji Wada, Tomoki Nakashima, Nishina Hiroshi, Josef M Penninger. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 2006.01; 12 (1): 17-25. ( PubMed, DOI )

  117. Isao Sakaida, Shuji Terai, Hiroshi Nishina, Kiwamu Okita. Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol. 2005.12; 38 (4): 197-202. ( PubMed, DOI )

  118. Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F Wagner, Tak W Mak, Edgar Serfling, Hiroshi Takayanagi. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med.. 2005.11; 202 (9): 1261-1269. ( PubMed, DOI )

  119. Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S Thorgeirsson, Kiwamu Okita. Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology. 2005.05; 128 (5): 1369-1380. ( PubMed )

  120. Kota Saito, Yasuhiro Araki, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada. Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem.. 2005.03; 137 (3): 423-430. ( PubMed, DOI )

  121. 和田悌司, 中島友樹, 仁科博史, Josef M Penninger. アダプター分子Gab2は骨密度を制御する 細胞工学. 2005; (24): 704-705.

  122. Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita. Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg. 2005; 12 (3): 203-207. ( PubMed, DOI )

  123. Kota Saito, Hiroaki Kajiho, Yasuhiro Araki, Hiroshi Kurosu, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada. Purification and analysis of RIN family-novel Rab5 GEFs. Meth. Enzymol.. 2005; 403 276-283. ( PubMed, DOI )

▼display all

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. 仁科 博史. Hippoシグナル経路の新展開　器官サイズと恒常性を制御するHippo-YAPシグナル伝達経路(The Hippo-YAP pathway regulates organ size and homeostasis). 日本細胞生物学会大会講演要旨集 2021.06.01

  2. 仁科 博史. 肝細胞の生物学Up to Date　細胞の競合と肝臓の恒常性(Cell competition and liver homeostasis). 糖尿病 2020.08.01

  3. 丸山 順一, 影近 弘之, 仁科 博史, 畑 裕. 新規に同定したYAP1活性化化合物は多発性骨髄腫細胞においてYAP1-p73経路依存的な細胞死を誘導する. 日本癌学会総会記事 2017.09.01

  4. 虞 若星, 岡本 好海[内田], 仁科 博史. タンパク質ファルネシル化を介したメバロン酸経路による原始線条形成の制御機構の解明. 日本薬学会年会要旨集 2017.03.01

  5. Hiroshi Nishina. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis . 6th Asian Oceania Zebrafish PI’s Meeting (AOZM), Hong Kong, USA 2013.07.19

  6. 仁科博史. Mouse Embryonic Stem Cell-Based Drug Screen for Novel Modulators of Cell Differentiation in Early Mammalian Embryogenesis. 熊本大学HIGO Program 2012.02.12

▼display all

To the head of this page.▲
 

Campus class subject 【 display / non-display 】

  • Development and Regenerative Bioscience，2014 - Now

  • Bioscience II，2013 - Now

  • Methods for studying the development

  • Molecular Cell Biology

To the head of this page.▲