Personnel Information

写真a

TAMAMURA Hirokazu


Job title

Professor

Birth date

1964
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Graduating School 【 display / non-display 】

  • Kyoto University, Faculty of Pharmaceutical Science, 1988, Graduated

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Degree 【 display / non-display 】

  • Doctor of Pharmacy, Kyoto University

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Campus Career 【 display / non-display 】

  • 2015.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biomolecular Chemistry， Medicinal Chemistry， Professor
  • 2014.04
    -
    2015.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Molecular Biomedicine， Professor
  • 2014.01
    -
    2015.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Medicinal Chemistry， Professor
  • 2015.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Medicinal Chemistry， Professor
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Research Areas 【 display / non-display 】

  • Drug development chemistry

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Published Papers & Misc 【 display / non-display 】

  • Miller SE, Tsuji K, Abrams RPM, Burke TR Jr, Schneider JP. Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein-Protein Interactions. Journal of the American Chemical Society. 2020.11; ( PubMed, DOI )

  • Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura. Bivalent HIV-1 fusion inhibitors based on peptidomimetics. Bioorganic & medicinal chemistry. 2020.10; 28 (24): 115812. ( PubMed, DOI )

  • Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura. A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy COMMUNICATIONS BIOLOGY. 2020.10; 3 1-10. ( PubMed, DOI )

  • Tsuji K, Hymel D, Burke TR. A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors. Analytical methods : advancing methods and applications. 2020.09; 12 (36): 4418-4421. ( PubMed, DOI )

  • Tsuji K, Owusu KB, Kobayakawa T, Wang R, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H. Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & medicinal chemistry. 2020.06; 28 (11): 115488. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  • The Frontier of Peptide Drug Discovery. 2019.05 (ISBN : 978-4-7813-1417-4)

  • Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi. Mid-size Drugs Based on Peptides and Peptidomimetics. 2018.01 (ISBN : 978-981-10-7691-6)

  • Ohashi N, Tamamura H. “Peptide-derived mid-sized anti-HIV agents” In “Amino Acids, Peptides and Proteins,” ed. by Maxim Ryadnov and Ferenc Hudecz, The Royal Society of Chemistry, Cambridge CB4 0WF, UK, vol. 41. 2017.01

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. tereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. The Japanese Peptide Society， 2016.03

  • Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Development of 8-Azacoumarin-4-ylmethyl-type Photolabile Protecting Groups Based on Amide-Alkene Isosterism. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

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Conference Activities & Talks 【 display / non-display 】

  • Hirokazu Tamamura. Bioimaging of GPCR dimers and its application to molecular probes for cancer cells. A3 Foresight & 5 Star Alliance Joint Workshop on Organic/Inorganic Hybrid Nano Materials and Bio Imaging 2020.12.03 online

  • Kaho Matsumoto, Takeo Kuwata, Zahid Hasan, Yu Kaku, Shashwata Biswas, Shokichi Takahama, Hirokazu Tamamura and Shuzo Matsushita. The CD4 mimetic compound YIR-821-mediated enhancement of the neutralization activities of plasma IgG against autologous isolates in vitro.. 21st Kumamoto AIDS Seminar 2020.11.11 online

  • Kofi Baffour-Awuah Owusu, Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Moemi Kaneko, Tsutomu Murakami, Hirokazu Tamamura. Exploratory studies on the development of anti-HIV-1 peptides based on HIV-1 capsid fragments. The 57th Japanese Peptide Symposium 2020.11.10 online

  • Kohei Tsuji, David Hyme, Buyong Ma, Ruth Nussinov, Hirokazu Tamamura,Terrence R. Burke, Jr.. Development of bivalent inhibitors of polo-like kinase 1 with great affinity enhancement. The 57th Japanese Peptide Symposium 2020.11.10 online

  • Wataru Nomura, Takumi Kamimura, Takuya Kobayakawa, Hirokazu Tamamura. Endogenous protein expression imaging by fluorogenic ZIP tag-probe system. The 57th Japanese Peptide Symposium 2020.11.10 online

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Campus class subject 【 display / non-display 】

  • ,

  • ,

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