Tsuji K, Tamamura H, Burke TR Jr. Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component. RSC chemical biology. 2024.07; 5 (8): 721-728. ( PubMed, DOI )

Ishii T, Kobayakawa T, Matsuda K, Nigorikawa K, Bolah P, Noborio A, Tsuji K, Ohashi N, Yoshimura K, Nomura W, Mitsuya H, Maeda K, Tamamura H. Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents. ACS infectious diseases. 2024.05; 10 (6): 2250-2261. ( PubMed, DOI )

Tsuji K, Tamamura H, Burke TR Jr. Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. Biological & pharmaceutical bulletin. 2024; 47 (7): 1282-1287. ( PubMed, DOI )

Kobayakawa T, Yokoyama M, Tsuji K, Boku S, Kurakami M, Fujino M, Ishii T, Miura Y, Nishimura S, Shinohara K, Yamamoto K, Bolah P, Kotani O, Murakami T, Sato H, Tamamura H. Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical & pharmaceutical bulletin. 2024; 72 (1): 41-47. ( PubMed, DOI )

Kobayakawa T, Takano H, Ishii T, Bolah P, Tsuji K, Ohashi N, Nomura W, Furuta T, Tamamura H. Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups. Chemical & pharmaceutical bulletin. 2024; 72 (3): 311-312. ( PubMed, DOI )

Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical and Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( PubMed, DOI )

Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura. Development of anti-HBV agents targeting HBV capsid proteins. RSC Medicinal Chemistry. 2023.10; 14 (10): 1973-1980. ( PubMed, DOI )

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of Medicinal Chemistry. 2023.10; 66 (19): 13516-13529. ( PubMed, DOI )

Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. European Journal of Medicinal Chemistry. 2023.08; 256 115449. ( PubMed, DOI )

Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki, Hirokazu Tamamura . Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2 RSC Advances. 2023.03; 13 8779-8793.

Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura, Hiroaki Mitsuya. Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature Communications. 2023.02; 14 (1): 1076. ( PubMed, DOI )

Kanako Matsuura, Mizuki Yamaura, Hiromi Sakawaki, Ai Himeno, Yalcin Pisil, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Shuzo Matsushita, Tomoyuki Miura. Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C. Virology. 2023.01; 578 171-179. ( PubMed, DOI )

Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Yuki Kishihara, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura. Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins. RSC Advances. 2023.01; 13 (3): 2156-2167. ( PubMed, DOI )

Kaho Matsumoto, Takeo Kuwata, William D Tolbert , Jonathan Richard, Shilei Ding, Jérémie Prévost, Shokichi Takahama, George P Judicate, Takamasa Ueno, Hirotomo Nakata, Takuya Kobayakawa, Kohei Tsuji , Hirokazu Tamamura, Amos B Smith 3rd, Marzena Pazgier, Andrés Finzi, Shuzo Matsushita. Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates. Journal of virology. 2022.12; e0163822. ( PubMed, DOI )

Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors Bioorganic & Medicinal Chemistry. 2022.12; 76 117083. ( PubMed, DOI )

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-Ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 25 (11): 105365. ( PubMed, DOI )

Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinov, Terrence R Burke Jr. Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1. RSC chemical biology. 2022.08; 3 (9): 1111-1120. ( PubMed, DOI )

Kohei Tsuji, Takuya Kobayakawa, Kiju Konno, Ami Masuda, Kohei Takahashi, Nami Ohashi, Kazuhisa Yoshimura, Takeo Kuwata, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors. Bioorganic & Medicinal Chemistry. 2022.02; 56 116616. ( PubMed, DOI )

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura & Hirokazu Tamamura. Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Organic & Biomolecular Chemistry. 2021.10; 19 (38): 8264-8271. ( PubMed, DOI )

David Hymel, Kohei Tsuji, Robert A Grant, Ramesh M Chingle, Dominique L Kunciw, Michael B Yaffe, Terrence R Burke Jr. Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles. Organic & Biomolecular Chemistry. 2021.09; 19 (36): 7843-7854. ( PubMed, DOI )

Hasan Md Zahid, Takeo Kuwata, Shokichi Takahama, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Hirokazu Tamamura & Shuzo Matsushita. Functional Analysis of a Monoclonal Antibody Reactive against the C1C2 of Env Obtained from a Patient Infected with HIV-1 CRF02_AG. Retrovirology. 2021.08; 18 (1): 23(article number).

Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura & Shiroh Futaki. Discovery of a Macropinocytosis-inducing Peptide Potentiated by Medium-mediated Intramolecular Disulfide Formation. Angewandte Chemie International Edition. 2021.05; 60 (21): 11928-11936.

Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji & Hirokazu Tamamura. Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. The Journal of Organic Chemistry. 2021.03; ( PubMed, DOI )

Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura. Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins. Biomolecules. 2021.02; 11 (2): ( PubMed, DOI )

Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura. Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of Medicinal Chemistry. 2021.01; ( PubMed, DOI )

Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in Microbiology. 2021; 12 636276. ( PubMed, DOI )

Tsuji K, Wang R, Kobayakawa T, Owusu KB, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H. Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & medicinal chemistry. 2020.12; 30 115923. ( PubMed, DOI )

Miller SE, Tsuji K, Abrams RPM, Burke TR Jr, Schneider JP. Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein-Protein Interactions. Journal of the American Chemical Society. 2020.11; ( PubMed, DOI )

Daisuke Matsumoto, Hirokazu Tamamura, Wataru Nomura. A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy Communications Biology. 2020.10; 3 1-10. ( PubMed, DOI )

Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura. Bivalent HIV-1 fusion inhibitors based on peptidomimetics. Bioorganic & medicinal chemistry. 2020.10; 28 (24): 115812. ( PubMed, DOI )

Tsuji K, Hymel D, Burke TR. A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors. Analytical methods : advancing methods and applications. 2020.09; 12 (36): 4418-4421. ( PubMed, DOI )

Tsuji K, Owusu KB, Kobayakawa T, Wang R, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H. Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & medicinal chemistry. 2020.06; 28 (11): 115488. ( PubMed, DOI )

Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura. Synthesis of hydrophilic caged DAG-lactones for chemical biology applications. Organic & biomolecular chemistry. 2020.05; ( PubMed, DOI )

Qi Junpeng, Tsuji Kohei, Hymel David, Burke Terrence R. Jr., Hudecek Michael, Rader Christoph, Peng Haiyong. Chemically Programmable and Switchable CAR-T Therapy ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020.05; ( PubMed, DOI )

Daisuke Matsumoto, Hirokazu Tamamura, Wataru Nomura. TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases Biochemistry . 2020.01; 59 (2): 197-204. ( PubMed, DOI )

Maeda Kenji, Matsuda Kouki, Islam Saiful, Kobayakawa Takuya, Tsuchiya Kiyoto, Hattori Shin-ichiro, Gatanaga Hiroyuki, Oka Shinichi, Yoshimura Kazuhisa, Tamamura Hirokazu, Mitsuya Hiroaki, Satou Yorifumi. HIV持続潜伏感染に関する最先端研究(Treatment of HIV-1-reservoirs using latency-reversing agents(LRAs) toward HIV cure) 日本エイズ学会誌. 2019.11; 21 (4): 314. ( ichushi )

Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura, Shuzo Matsushita. Synergistic Inhibition of Cell-to-cell HIV-1 Infection by Combinations of Single Chain Variable Fragments and Fusion Inhibitors Biochem Biophys Rep.. 2019.09; 20 100687.

Kobayakawa Takuya, Tamamura Hirokazu. Development for Peptidomimetic Chemistry based on Chloroalkene Structures JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN. 2019.09; 77 (9): 904-911.

Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura. Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors. Chembiochem. 2019.08; 20 (16): 2101-2108. ( PubMed, DOI )

Maeda K, Das D, Kobayakawa T, Tamamura H, Takeuchi H. Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication. Current topics in medicinal chemistry. 2019.07; 19 (18): 1621-1649. ( PubMed, DOI )

Maxwell M Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Development of a NanoBRET-Based Sensitive Screening Method for CXCR4 Ligands. Bioconjug. Chem.. 2019.05; 30 (5): 1442-1450. ( PubMed, DOI )

Sakyiamah Maxwell M., Kobayakawa Takuya, Fujino Masayuki, Konno Makoto, Narumi Tetsuo, Tanaka Tomohiro, Nomura Wataru, Yamamoto Naoki, Murakami Tsutomu, Tamamura Hirokazu. Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands BIOORGANIC & MEDICINAL CHEMISTRY. 2019.03; 27 (6): 1130-1138. ( DOI )

Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada, Hirokazu Tamamura. Soluble-type small-molecule CD4 mimics as HIV entry inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2019.03; 29 (5): 719-723. ( PubMed, DOI )

Akinobu Z. Suzuki, Ryota Sekine, Shiori Takeda, Ryosuke Aikawa, Yukiko Shiraishi, Tomomi Hamaguchi, Hiroyuki Okuno, Tamamura Hirokazu, Furuta Toshiaki. A clickable caging group as a new platform for modular caged compounds with improved photochemical properties CHEMICAL COMMUNICATIONS. 2019.01; 55 (4): 451-454. ( PubMed, DOI )

Matsuda K, Kobayakawa T, Tsuchiya K, Hattori SH, Nomura W, Gatanaga H, Yoshimura K, Oka S, Endo Y, Tamamura H, Mitsuya H, Maeda K. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal. The Journal of biological chemistry. 2019.01; 294 (1): 116-129. ( PubMed, DOI )

Nomura W, Matsumoto D, Sugii T, Kobayakawa T, Tamamura H. Efficient and orthogonal transcription regulation by chemically inducible artificial transcription factors. Biochemistry. 2018.10; 57 (45): 6452-6459. ( PubMed, DOI )

Kobayakawa T, Ohashi N, Hirota Y, Takahashi K, Yamada Y, Narumi T, Yoshimura K, Matsushita S, Harada S, Tamamura H. Flexibility of small molecular CD4 mimics as HIV entry inhibitors. Bioorganic & medicinal chemistry. 2018.10; 26 (21): 5664-5671. ( PubMed, DOI )

Kei Toyama, Takuya Kobayakawa, Wataru Nomura, Hirokazu Tamamura. Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR Chemical and Pharmaceutical Bulletin. 2018.09; 66 (11): 1083-1089.

Kei Toyama, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjugate Chemistry. 2018.06; 29 (6): 2050-2057. ( PubMed, DOI )

Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu, Hirokazu Tamamura. Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application. ACS Medicinal Chemistry Letters. 2018.01; 9 (1): 6-10. ( PubMed, DOI )

Nomura Wataru, Matsumoto Daisuke, Hashimoto Tsukasa, Sugii Taisuke, Tamamura Hirokazu. Development of chemical-inducible artificial transcription factors based on sequence-specific DNA binders ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2017.08; 254

Kobayakawa T, Tamamura H. Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation. Tetrahedron. 2017.07; 73 (30): 4464-4471.

Ohashi N, Kobayashi R, Nomura W, Kobayakawa T, Czikora A, Herold B K, Lewin N E, Blumberg P M, Tamamura H. Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands. Bioconjugate Chem. 2017.07; ( DOI )

Kobayakawa Takuya, Tamamura Hirokazu. Stereoselective synthesis of Xaa-Yaa type (Z)-chloroalkene dipeptide isosteres via efficient utilization of organocopper reagents mediated allylic alkylation TETRAHEDRON. 2017.07; 73 (30): 4464-4471. ( DOI )

Kobayashi K, Mizuguchi T, Hattori Y, Ohara N, Ninomiya R, Iida M, Ooe H, Yamazaki Y, Takata M, Tamamura H, Akaji K. Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor. J. Pept. Sci. 2017.04; ( DOI )

Takano Hikaru, Narumi Tetsuo, Nomura Wataru, Tamamura Hirokazu. Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization JOURNAL OF ORGANIC CHEMISTRY. 2017.03; 82 (5): 2739-2744. ( PubMed, DOI )

Takano T, Narumi T, Nomura W, Tamamura H. Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization. J. Org. Chem. 2017.02; 82 (5): 2739-2744.

Tanaka T, Aoki T, Nomura W, Tamamura H . Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells. J. Pept. Sci. 2017.01; ( DOI )

Mizuguchi T, Ohashi N, Matsumoto D, Hashimoto C, Nomura W, Yamamoto N, Murakami T, Tamamura. Development of Anti-HIV Peptides Based on a Viral Capsid Protein. Biopolymers: Peptide Science. 2017.01; 108 (1): ( DOI )

Mizuguchi T, Harada S, Miura T, Ohashi N, Narumi T, Mori H, Irahara Y, Yamada Y, Nomura W, Matsushita S, Yoshimura K, Tamamura H. A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor Bioorg. Med. Chem. Lett . 2016; 2 (26): 397-400.

Abduelmula A, Huang R, Pu Q, Tamamura H, Puopolo G. M & Saberi B. B. SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite. Int. J. Dev. Biol. 2016; 60(1-2-3) (29-38):

Ohashi N, Harada S, Mizuguchi T, Irahara Y, Yamada Y, Kotani M, Nomura W, Matsushita S, Yoshimura K, Tamamura H. Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors. ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions. 2016; 11 (8): 940-946.

Kobayakawa T, Tamamura H. Efficient Synthesis of Xaa-Gly Type (Z)-Chloroalkene Dipeptide Isosteres via Organocuprate Mediated Reduction. Tetrahedron. 2016; 72 (32): 4968-4971.

Toyama K, Mizuguchi T, Nomura W, Tamamura H. Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization Bioorg. Med. Chem. 2016; 24 (16): 3406-3412.

Hiramatsu K, Tamamura H. A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst. Eur. J. Org. Chem. 2016; 21 3491-3494.

Takano H, Narumi T, Nomura W, Tamamura H. Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization J. Org. Chem. 2016; in press

Nakamura T, Campbell J.R, Moore A.R, Otsu S, Aikawa H, Tamamura H, Mitsuya H. Development and Validation of a Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization J. Virol. Methods. 2016; 236 196-206.

Nomura W, Mizuguchi T & Tamamura H. Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines Biopolymers: Peptide Science. 2016; 106 (4): 622-628.

Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura. Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines Biopolymers: Peptide Science. 2015.11; ( DOI )

Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group Org Lett. 2015; 21 (17): 5372-5375.

Kobayakawa T, Narumi T, Tamamura H. Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres. Org Lett. 2015; 10 (17): 2302-2305.

Mizuguchi T, Ohashi N, Nomura W, Komoriya M, Hashimoto C, Yamamoto N, Murakami T, Tamamura H. Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins. Bioorg Med Chem. 2015; 15 (23): 4423-4427.

Nomura W, Ohashi N, Mori A, Tamamura H. An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides. Bioconjugate Chem. 2015; 6 (26): 1080-1085.

Nomura W, Koseki T, Ohashi N, Mizuguchi T, Tamamura H. Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression. Org Biomol Chem. 2015; 32 (13): 8734-8739.

Nomura W, Aikawa H, Taketomi S, Tanabe M, Mizuguchi T, Tamamura H. Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands Bioorg Med Chem. 2015; 21 (23): 6967-6973.

Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura. Isostere-Based Design of 8-Azacoumarin-type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls. Org. Lett.,. 2014; 16 (4): 1184-1187.

Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura . Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer. Chem. Pharm. Bull., . 2014; 62 (10): 1019-1025.

Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka. Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker. Tetrahedron,. 2014; 70 (34): 5122-5127.

Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura. Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups. Tetrahedron, . 2014; 70 (29): 4400-4404.

Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka. Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins. Org. Biomol. Chem.,. 2014; 12 (23): 3821-3826.

Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura. Low-molecular-weight CXCR4 ligands with variable spacers. ChemMedChem. 2013.01; 8 (1): 118-124. ( PubMed, DOI )

Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura. Low Molecular Weight CXCR4 Ligands with Variable Spacers. ChemMedChem,. 2013; 8 (1): 118-124.

Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura. A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics. Bioorg. Med. Chem.,. 2013; 21 (24): 7884-7889.

Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura. CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies. Bioorg. Med. Chem.,. 2013; 21 (22): 6878-6885.

Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi. Generation of a Replication-competent Simian–human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic. J. Gen. Virol.,. 2013; 94 (12): 2710-2716.

Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura. Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Product. ACS Chem. Biol.,. 2013; 8 (10): 2235-2244.

Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura. Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4. ChemMedChem,. 2013; 8 (10): 1668-1672.

Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura. Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors. Bioorg. Med. Chem.,. 2013; 21 (15): 4452-4458.

Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura. CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents. Bioorg. Med. Chem.,. 2013; 21 (9): 2518-2526.

Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura. Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C Biopolymers. 2013; 100 (6): 613-620.

Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike, Hirokazu Tamamura. Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation. Organic Letters. 2012.09; 14 (17): 4490-4493. ( PubMed, DOI )

Narumi T, Tanaka T, Hashimoto C, Nomura W, Aikawa H, Sohma A, Itotani K, Kawamata M, Murakami T, Yamamoto N, Tamamura H. Pharmacophore-based small molecule CXCR4 ligands. Bioorg Med Chem Lett. 2012.06; 22 (12): 4169-4172. ( PubMed, DOI )

Hashimoto C, Nomura W, Ohya A, Urano E, Miyauchi K, Narumi T, Aikawa H, Komano JA, Yamamoto N, Tamamura H. Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines. Bioorg Med Chem. 2012.05; 20 (10): 3287-3291. ( PubMed, DOI )

Nomura W, Hashimoto C, Ohya A, Miyauchi K, Urano E, Tanaka T, Narumi T, Nakahara T, Komano JA, Yamamoto N, Tamamura H. A synthetic C34 trimer of HIV-1 gp41 shows significant increase in inhibition potency. ChemMedChem. 2012.02; 7 (2): 205-208. ( PubMed, DOI )

Nomura W, Masuda A, Ohba K, Urabe A, Ito N, Ryo A, Yamamoto N, Tamamura H. Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system. Biochemistry. 2012.02; 51 (7): 1510-1517. ( PubMed, DOI )

Narumi T, Komoriya M, Hashimoto C, Wu H, Nomura W, Suzuki S, Tanaka T, Chiba J, Yamamoto N, Murakami T, Tamamura H. Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins. Bioorg Med Chem. 2012.02; 20 (4): 1468-1474. ( PubMed, DOI )

Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura. Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation. Org. Lett., 14(17), 4490-4493. 2012; 14 (17): 4490-4493.

Narumi T, Arai H, Yoshimura K, Harada S, Nomura W, Matsushita S, Tamamura H. Small molecular CD4 mimics as HIV entry inhibitors. Bioorg Med Chem. 2011.11; 19 (22): 6735-6742. ( PubMed, DOI )

Hashimoto C, Tanaka T, Narumi T, Nomura W, Tamamura H. The successes and failures of HIV drug discovery. Expert Opin Drug Discov. 2011.10; 6 (10): 1067-1090. ( PubMed, DOI )

Yamada M, Kubo H, Kobayashi S, Ishizawa K, He M, Suzuki T, Fujino N, Kunishima H, Hatta M, Nishimaki K, Aoyagi T, Tokuda K, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M. The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. Cell Mol Immunol. 2011.07; 8 (4): 305-314. ( PubMed, DOI )

Xu C, Liu J, Chen L, Liang S, Fujii N, Tamamura H, Xiong H. HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Glia. 2011.06; 59 (6): 997-1007. ( PubMed, DOI )

Nomura W, Ohashi N, Okuda Y, Narumi T, Ikura T, Ito N, Tamamura H. Fluorescence-quenching screening of protein kinase C ligands with an environmentally sensitive fluorophore. Bioconjug Chem. 2011.05; 22 (5): 923-930. ( PubMed, DOI )

Tanaka T, Narumi T, Ozaki T, Sohma A, Ohashi N, Hashimoto C, Itotani K, Nomura W, Murakami T, Yamamoto N, Tamamura H. Azamacrocyclic metal complexes as CXCR4 antagonists. ChemMedChem. 2011.05; 6 (5): 834-839. ( PubMed, DOI )

Nomura W, Narumi T, Ohashi N, Serizawa Y, Lewin NE, Blumberg PM, Furuta T, Tamamura H. Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem. 2011.03; 12 (4): 535-539. ( PubMed, DOI )

Tsutsumi H, Abe S, Mino T, Nomura W, Tamamura H. Intense blue fluorescence in a leucine zipper assembly. Chembiochem. 2011.03; 12 (5): 691-694. ( PubMed, DOI )

Ohashi N, Nomura W, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H. Fluorescent-responsive synthetic C1b domains of protein kinase Cdelta as reporters of specific high-affinity ligand binding. Bioconjug Chem. 2011.01; 22 (1): 82-87. ( PubMed, DOI )

Tanaka T, Nomura W, Narumi T, Masuda A, Tamamura H. Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells. J Am Chem Soc. 2010.11; 132 (45): 15899-15901. ( PubMed, DOI )

Yoshimura K, Harada S, Shibata J, Hatada M, Yamada Y, Ochiai C, Tamamura H, Matsushita S. Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds. J Virol. 2010.08; 84 (15): 7558-7568. ( PubMed, DOI )

Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. Peptidic HIV integrase inhibitors derived from HIV gene products: Structure-activity relationship studies. Bioorg Med Chem. 2010.07; 18 6771-6775. ( PubMed, DOI )

Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products. J Med Chem. 2010.07; 53 (14): 5356-5360. ( PubMed, DOI )

Melchionna R, Di Carlo A, De Mori R, Cappuzzello C, Barberi L, Musaro A, Cencioni C, Fujii N, Tamamura H, Crescenzi M, Capogrossi MC, Napolitano M, Germani A. Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors. Muscle Nerve. 2010.06; 41 (6): 828-835. ( PubMed, DOI )

Aoki T, Shimizu S, Urano E, Futahashi Y, Hamatake M, Tamamura H, Terashima K, Murakami T, Yamamoto N, Komano J. Improvement of lentiviral vector-mediated gene transduction by genetic engineering of the structural protein Pr55(Gag). Gene Ther. 2010.04; 17 (9): 1124-1133. ( PubMed, DOI )

Nakahara T, Nomura W, Ohba K, Ohya A, Tanaka T, Hashimoto C, Narumi T, Murakami T, Yamamoto N, Tamamura H. Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies. Bioconjug Chem. 2010.04; 21 (4): 709-714. ( PubMed, DOI )

Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H. CD4 mimics targeting the mechanism of HIV entry. Bioorg Med Chem Lett. 2010.01; 20 (1): 354-358. ( PubMed, DOI )

Narumi T, Ochiai C, Yoshimura K, Harada S, Tanaka T, Nomura W, Arai H, Ozaki T, Ohashi N, Matsushita S, Tamamura H. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorg Med Chem Lett. 2010; 20 5853-5858. ( PubMed, DOI )

Nomura W, Mino T, Narumi T, Ohashi N, Masuda A, Hashimoto C, Tsutsumi H, Tamamura H. Development of crosslink-type tag-probe pairs for fluorescent imaging of proteins. Biopolymers. 2010; 94 843-852. ( PubMed, DOI )

Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H. Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. J Pept Sci. 2009.10; 15 (10): 642-646. ( PubMed, DOI )

Tanaka T, Nomura W, Narumi T, Esaka A, Oishi S, Ohashi N, Itotani K, Evans BJ, Wang ZX, Peiper SC, Fujii N, Tamamura H. Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids. Org Biomol Chem. 2009.09; 7 (18): 3805-3809. ( PubMed, DOI )

Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K. A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor. J Med Chem. 2009.02; ( PubMed, DOI )

Mizukoshi F, Baba K, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Tamamura H, Oishi S, Fujii N, Tsujimoto H. Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus. J Vet Med Sci. 2009.01; 71 (1): 121-124. ( PubMed )

Tsutsumi H, Nomura W, Abe S, Mino T, Masuda A, Ohashi N, Tanaka T, Ohba K, Yamamoto N, Akiyoshi K, Tamamura H. Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells. Angew Chem Int Ed Engl. 2009; 48 (48): 9164-9166. ( PubMed, DOI )

Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S, Fujii N. Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates. Adv Exp Med Biol. 2009; 611 149-150. ( PubMed )

Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N. Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Adv Exp Med Biol. 2009; 611 145-146. ( PubMed )

Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T, Ohba K, Yamamoto N, Fujii N, Tamamura H. Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore. Org Biomol Chem. 2008.12; 6 (23): 4374-4377. ( PubMed, DOI )

Nomura W, Tanabe Y, Tsutsumi H, Tanaka T, Ohba K, Yamamoto N, Tamamura H. Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening. Bioconjug Chem. 2008.09; 19 (9): 1917-1920. ( PubMed, DOI )

Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H. Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob Agents Chemother. 2008.06; 52 (6): 2111-2119. ( PubMed, DOI )

Driessen WH, Fujii N, Tamamura H, Sullivan SM. Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. Mol Ther. 2008.03; 16 (3): 516-524. ( PubMed, DOI )

Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii. A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists. Expert Opin. Drug Discovery. 2008; 3 (10): 1150-1166.

Tamamura H, Tsutsumi H, Nomura W, Fujii N. Exploratory studies on development of the chemokine receptor CXCR4 antagonists toward downsizing. Perspect Medicin Chem. 2008; 2 1-9. ( PubMed )

Kasiyanov A, Fujii N, Tamamura H, Xiong H. Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1alpha in the developing hippocampus. Dev Neurosci. 2008; 30 (4): 285-292. ( PubMed, DOI )

Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M, Sakabe J, Yoshiki R, Tamamura H, Fujii N, Inaba K, Tokura Y. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol. 2007.10; 171 (4): 1249-1257. ( PubMed, DOI )

Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y. CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun. 2007.10; 361 (4): 1012-1016. ( PubMed, DOI )

Kubonishi S, Kikuchi T, Yamaguchi S, Tamamura H, Fujii N, Watanabe T, Arenzana-Seisdedos F, Ikeda K, Matsui T, Tanimoto M, Katayama Y. Rapid hematopoietic progenitor mobilization by sulfated colominic acid. Biochem Biophys Res Commun. 2007.04; 355 (4): 970-975. ( PubMed, DOI )

Berchiche YA, Chow KY, Lagane B, Leduc M, Percherancier Y, Fujii N, Tamamura H, Bachelerie F, Heveker N. Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. J Biol Chem. 2007.02; 282 (8): 5111-5115. ( PubMed, DOI )

Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N. Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem. 2007.01; 50 (2): 192-198. ( PubMed, DOI )

Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii. Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis. Lett. Drug Design Discovery. 2007; 4 20-26.

Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii. Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics. Tetrahedron. 2007; 63 9243-9254.

Tsutsumi H, Tanaka T, Ohashi N, Masuno H, Tamamura H, Hiramatsu K, Araki T, Ueda S, Oishi S, Fujii N. Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents. Biopolymers. 2007; 88 (2): 279-289. ( PubMed, DOI )

Tamamura H, Tsutsumi H, Masuno H, Fujii N. Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. Curr Med Chem. 2007; 14 (1): 93-102. ( PubMed )

Tamamura H, Tsutsumi H, Fujii N. The chemokine receptor CXCR4 as a therapeutic target for several diseases. Mini Rev Med Chem. 2006.09; 6 (9): 989-995. ( PubMed )

Tamamura H, Ojida A, Ogawa T, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Hamachi I, Fujii N. Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure. J Med Chem. 2006.06; 49 (11): 3412-3415. ( PubMed, DOI )

Tamamura H, Tsutsumi H, Masuno H, Mizokami S, Hiramatsu K, Wang Z, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Fujii N. Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. Org Biomol Chem. 2006.06; 4 (12): 2354-2357. ( PubMed, DOI )

Hanaoka H, Mukai T, Tamamura H, Mori T, Ishino S, Ogawa K, Iida Y, Doi R, Fujii N, Saji H. Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol. 2006.05; 33 (4): 489-494. ( PubMed, DOI )

Niida A, Tanigaki H, Inokuchi E, Sasaki Y, Oishi S, Ohno H, Tamamura H, Wang Z, Peiper SC, Kitaura K, Otaka A, Fujii N. Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. J Org Chem. 2006.05; 71 (10): 3942-3951. ( PubMed, DOI )

Menu E, Asosingh K, Indraccolo S, De Raeve H, Van Riet I, Van Valckenborgh E, Vande Broek I, Fujii N, Tamamura H, Van Camp B, Vanderkerken K. The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model. Haematologica. 2006.05; 91 (5): 605-612. ( PubMed )

Kasyanov A, Tamamura H, Fujii N, Xiong H. HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus. Eur J Neurosci. 2006.03; 23 (5): 1120-1128. ( PubMed, DOI )

Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, Fujii N. Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett. 2006.01; 16 (1): 134-137. ( PubMed, DOI )

Tamamura H, Tsutsumi H. Specific probes for chemokine receptors. Chem Biol. 2006.01; 13 (1): 8-10. ( PubMed, DOI )

Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii. Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides. Tetrahedron. 2006; 62 1416-1424.

Hirokazu Tamamura & Hiroshi Tsutsumi. Specific Probes for Chemokine Receptors Chem. Biol.. 2006; 13 8-10.

Tamamura H, Esaka A, Ogawa T, Araki T, Ueda S, Wang Z, Trent JO, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N. Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. Org Biomol Chem. 2005.12; 3 (24): 4392-4394. ( PubMed, DOI )

Tamamura H, Fujii N. The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. Expert Opin Ther Targets. 2005.12; 9 (6): 1267-1282. ( PubMed, DOI )

Ueda S, Fujita M, Tamamura H, Fujii N, Otaka A. Photolabile protection for one-pot sequential native chemical ligation. Chembiochem. 2005.11; 6 (11): 1983-1986. ( PubMed, DOI )

Tamamura H, Otaka A, Fujii N. Development of anti-HIV agents targeting dynamic supramolecular mechanism: entry and fusion inhibitors based on CXCR4/CCR5 antagonists and gp41-C34-remodeling peptides. Curr HIV Res. 2005.10; 3 (4): 289-301. ( PubMed )

Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, Fujii N, Kipps TJ, Burger JA. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood. 2005.09; 106 (5): 1824-1830. ( PubMed, DOI )

Tamamura H, Araki T, Ueda S, Wang Z, Oishi S, Esaka A, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N. Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. J Med Chem. 2005.05; 48 (9): 3280-3289. ( PubMed, DOI )

Zannettino AC, Farrugia AN, Kortesidis A, Manavis J, To LB, Martin SK, Diamond P, Tamamura H, Lapidot T, Fujii N, Gronthos S. Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res. 2005.03; 65 (5): 1700-1709. ( PubMed, DOI )

Percherancier Y, Berchiche YA, Slight I, Volkmer-Engert R, Tamamura H, Fujii N, Bouvier M, Heveker N. Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem. 2005.03; 280 (11): 9895-9903. ( PubMed, DOI )

Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood. 2005.02; 105 (3): 931-939. ( PubMed, DOI )

Nameki D, Kodama E, Ikeuchi M, Mabuchi N, Otaka A, Tamamura H, Ohno M, Fujii N, Matsuoka M. Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions. J Virol. 2005.01; 79 (2): 764-770. ( PubMed, DOI )

Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005.01; 48 (2): 380-391. ( PubMed, DOI )

Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka. Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2' Reactions. Tetrahedron Lett.. 2005; 46 4183-4186.

Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent. A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools. QSAR Comb. Sci.. 2005; 24 (5): 620-630.

Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum. New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion Eur. Urol.. 2005; 48 (6): 1025-1030.

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C). J Med Chem. 2004.09; 47 (20): 4858-4864. ( PubMed, DOI )

Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004.09; 5 (9): 943-952. ( PubMed, DOI )

Otaka A, Ueda S, Tomita K, Yano Y, Tamamura H, Matsuzaki K, Fujii N. Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation. Chem Commun (Camb). 2004.08; (15): 1722-1723. ( PubMed, DOI )

Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N. Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Lett. 2004.07; 569 (1-3): 99-104. ( PubMed, DOI )

Tamamura H, Fujii N. Two orthogonal approaches to overcome multi-drug resistant HIV-1s: development of protease inhibitors and entry inhibitors based on CXCR4 antagonists. Curr Drug Targets Infect Disord. 2004.06; 4 (2): 103-110. ( PubMed )

Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatl J, Rabenau H, Doerr HW, Hunsmann G, Otaka A, Tamamura H, Fujii N, Yamamoto N. HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun. 2004.06; 318 (3): 719-725. ( PubMed, DOI )

Peng H, Huang Y, Rose J, Erichsen D, Herek S, Fujii N, Tamamura H, Zheng J. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res. 2004.04; 76 (1): 35-50. ( PubMed, DOI )

Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem. 2004.04; 2 (8): 1255-1257. ( PubMed, DOI )

Otaka A, Watanabe J, Yukimasa A, Sasaki Y, Watanabe H, Kinoshita T, Oishi S, Tamamura H, Fujii N. SmI2-mediated reduction of gamma,gamma-difluoro-alpha,beta-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipeptide isosteres. J Org Chem. 2004.03; 69 (5): 1634-1645. ( PubMed, DOI )

Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones. J Med Chem. 2004.01; 47 (3): 644-655. ( PubMed, DOI )

Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M. CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther. 2004.01; 3 (1): 29-37. ( PubMed )

Mitsuko Takenaga, Hirokazu Tamamura, Kenichi Hiramatsu, Natsumi Nakamura, Yoko Yamaguchi, Aki Kitagawa, Shinichi Kawai, Hideki Nakashima, Nobutaka Fujii & Rie Igarashi. A Single Treatment with Microcapsules Containing a CXCR4 Antagonist Suppresses Pulmonary Metastasis of Murine Melanoma. Biochem. Biophys. Res. Commun.. 2004; 320 (1): 226-232.

Tamamura H, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem. 2003.11; 1 (21): 3656-3662. ( PubMed )

Trent JO, Wang ZX, Murray JL, Shao W, Tamamura H, Fujii N, Peiper SC. Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem. 2003.11; 278 (47): 47136-47144. ( PubMed, DOI )

Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem. 2003.11; 1 (21): 3663-3669. ( PubMed )

Oonuma T, Morimatsu M, Nakagawa T, Uyama R, Sasaki N, Nakaichi M, Tamamura H, Fujii N, Hashimoto S, Yamamura H, Syuto B. Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat. J Vet Med Sci. 2003.10; 65 (10): 1069-1073. ( PubMed )

Otaka A, Yukimasa A, Watanabe J, Sasaki Y, Oishi S, Tamamura H, Fujii N. Application of samarium diiodide (SmI2)-induced reduction of gamma-acetoxy-alpha,beta-enoates with alpha-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives. Chem Commun (Camb). 2003.08; (15): 1834-1835. ( PubMed )

Tamamura H, Hori A, Kanzaki N, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N. T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer. FEBS Lett. 2003.08; 550 (1-3): 79-83. ( PubMed )

Tamamura H, Kato T, Otaka A, Fujii N. Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies. Org Biomol Chem. 2003.07; 1 (14): 2468-2473. ( PubMed )

Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC. Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed Engl. 2003.07; 42 (28): 3251-3253. ( PubMed, DOI )

Yasuda T, Poole AR, Shimizu M, Nakagawa T, Julovi SM, Tamamura H, Fujii N, Nakamura T. Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture. Arthritis Rheum. 2003.05; 48 (5): 1271-1280. ( PubMed, DOI )

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains. J Med Chem. 2003.04; 46 (9): 1764-1768. ( PubMed, DOI )

Fujii N, Nakashima H, Tamamura H. The therapeutic potential of CXCR4 antagonists in the treatment of HIV. Expert Opin Investig Drugs. 2003.02; 12 (2): 185-195. ( PubMed, DOI )

Otaka A, Nakamura M, Nameki D, Kodama E, Uchiyama S, Nakamura S, Nakano H, Tamamura H, Kobayashi Y, Matsuoka M, Fujii N. Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells. Angew Chem Int Ed Engl. 2002.08; 41 (16): 2937-2940. ( PubMed, DOI )

Oishi S, Kamano T, Niida A, Odagaki Y, Hamanaka N, Yamamoto M, Ajito K, Tamamura H, Otaka A, Fujii N. Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics. J Org Chem. 2002.08; 67 (17): 6162-6173. ( PubMed )

Otaka A, Katagiri F, Kinoshita T, Odagaki Y, Oishi S, Tamamura H, Hamanaka N, Fujii N. Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions. J Org Chem. 2002.08; 67 (17): 6152-6161. ( PubMed )

Zhang WB, Navenot JM, Haribabu B, Tamamura H, Hiramatu K, Omagari A, Pei G, Manfredi JP, Fujii N, Broach JR, Peiper SC. A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 2002.07; 277 (27): 24515-24521. ( PubMed, DOI )

Tamamura H, Omagari A, Hiramatsu K, Oishi S, Habashita H, Kanamoto T, Gotoh K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study. Bioorg Med Chem. 2002.05; 10 (5): 1417-1426. ( PubMed )

Oishi S, Kamano T, Niida A, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N. Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction. Org Lett. 2002.04; 4 (7): 1051-1054. ( PubMed )

Oishi S, Niida A, Kamano T, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N. Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction. Org Lett. 2002.04; 4 (7): 1055-1058. ( PubMed )

Tamamura H, Hiramatsu K, Miyamoto K, Omagari A, Oishi S, Nakashima H, Yamamoto N, Kuroda Y, Nakagawa T, Otaka A, Fujii N. Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety. Bioorg Med Chem Lett. 2002.03; 12 (6): 923-928. ( PubMed )

Hirokazu Tamamura, Tadakazu Hori, Akira Otaka & Nobutaka Fujii. Efficient Stereoselective Synthesis of Peptidomimetics Containing Hydroxyethylamine Dipeptide Isosteres Utilizing the Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(5)): 577-580.

Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii. Regio- and Stereoselective Ring-opening of Chiral 1,3-Oxazolidin-2-one Derivatives by Organocopper Reagents Provides Novel Access to Di-, tri- and tetra-substituted Alkene Dipeptide Isosteres. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(15)): 1786-1793.

Tamamura H. [Development of selective antagonists against an HIV second receptor] Yakugaku Zasshi. 2001.11; 121 (11): 781-792. ( PubMed )

Fujii N, Tamamura H. Peptide-lead CXCR4 antagonists with high anti-HIV activity. Curr Opin Investig Drugs. 2001.09; 2 (9): 1198-1202. ( PubMed )

Tamamura H, Omagari A, Hiramatsu K, Kanamoto T, Gotoh K, Kanbara K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation. Bioorg Med Chem. 2001.08; 9 (8): 2179-2187. ( PubMed )

Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001.07; 11 (14): 1897-1902. ( PubMed )

Gotoh K, Yoshimori M, Kanbara K, Tamamura H, Kanamoto T, Mochizuki K, Fujii N, Nakashima H. Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1. J Infect Chemother. 2001.03; 7 (1): 28-36. ( PubMed, DOI )

Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Peiper SC, Hamanaka N, Otaka A, Fujii N. Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. Bioorg Med Chem Lett. 2001.02; 11 (3): 359-362. ( PubMed )

Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii. New Access to α-Substituted (Z)-Fluoroalkene Dipeptide Isosteres Utilizing Organocopper Reagents under 'Reduction-oxidative Alkylation (R-OA)' Conditions. Tetrahedron Lett.. 2001; 42 (2): 5443-5446.

Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka & Nobutaka Fujii. Stereoselective Synthesis of a Set of Two Functionalized (E)-Alkene Dipeptide Isosteres of L-Amino Acid-L-Glu and L-Amino acid-D-Glu. J. Chem. Soc., Perkin Trans.. 2001; 1 (19): 2445-2451.

Kenji Kanbara, Setsuko Sato, Jun-ichi Tanuma, Hirokazu Tamamura, Kazuyo Gotoh, Manabu Yoshimori, Taisei Kanamoto, Motoo Kitano, Nobutaka Fujii & Hideki Nakashima. Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134. AIDS Res. Hum. Retroviruses. 2001; 17 (7): 615-622.

玉村　啓和. HIV侵入の第二受容体に対する特異的拮抗剤の発見と応用に関する研究 薬学雑誌. 2001; 121 (11): 781-792.

Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N. Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorg Med Chem Lett. 2000.12; 10 (23): 2633-2637. ( PubMed )

Miyoshi K, Otaka A, Kaneko M, Tamamura H, Fujii N. A new practical strategy for the synthesis of long-chain phosphopeptide. Chem Pharm Bull (Tokyo). 2000.08; 48 (8): 1230-1233. ( PubMed )

Udaka K, Wiesmuller KH, Kienle S, Jung G, Tamamura H, Yamagishi H, Okumura K, Walden P, Suto T, Kawasaki T. An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries. Immunogenetics. 2000.08; 51 (10): 816-828. ( PubMed )

Otaka A, Mitsuyama E, Kinoshita T, Tamamura H, Fujii N. Stereoselective synthesis of CF(2)-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures. J Org Chem. 2000.08; 65 (16): 4888-4899. ( PubMed )

Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C. J Med Chem. 2000.08; 43 (17): 3209-3217. ( PubMed )

Kakugawa K, Udaka K, Nakashima K, Inaba K, Oka Y, Sugiyama H, Tamamura H, Yamagishi H. Efficient induction of peptide-specific cytotoxic T lymphocytes by LPS-activated spleen cells. Microbiol Immunol. 2000; 44 (2): 123-133. ( PubMed )

Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura & Nobutaka Fujii. Development of New Methodology for the Synthesis of Functionalized α-Fluorophosphonates and Its Practical Application to the Preparation of Phosphopeptide Mimetics. Chem. Commun.. 2000; 1081-1082.

Murakami T, Zhang TY, Koyanagi Y, Tanaka Y, Kim J, Suzuki Y, Minoguchi S, Tamamura H, Waki M, Matsumoto A, Fujii N, Shida H, Hoxie JA, Peiper SC, Yamamoto N. Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection. J Virol. 1999.09; 73 (9): 7489-7496. ( PubMed )

Xu Y, Tamamura H, Arakaki R, Nakashima H, Zhang X, Fujii N, Uchiyama T, Hattori T. Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4. AIDS Res Hum Retroviruses. 1999.03; 15 (5): 419-427. ( PubMed, DOI )

Arakaki R, Tamamura H, Premanathan M, Kanbara K, Ramanan S, Mochizuki K, Baba M, Fujii N, Nakashima H. T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure. J Virol. 1999.02; 73 (2): 1719-1723. ( PubMed )

Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka & Nobutaka Fujii. Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing α,β-Unsaturated Ester Groups. J. Chem. Soc., Perkin Trans.. 1999; 1 2983-2996.

Tamamura H, Xu Y, Hattori T, Zhang X, Arakaki R, Kanbara K, Omagari A, Otaka A, Ibuka T, Yamamoto N, Nakashima H, Fujii N. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998.12; 253 (3): 877-882. ( PubMed, DOI )

Hattori T, Komoda H, Pahwa S, Tateyama M, Zhang X, Xu Y, Oguma S, Tamamura H, Fujii N, Fukutake K, Uchiyama T. Decline of anti-DP107 antibody associated with clinical progression. AIDS. 1998.08; 12 (12): 1557-1559. ( PubMed )

Tamamura H, Imai M, Ishihara T, Masuda M, Funakoshi H, Oyake H, Murakami T, Arakaki R, Nakashima H, Otaka A, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N. Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection. Bioorg Med Chem. 1998.07; 6 (7): 1033-1041. ( PubMed )

Oguchi M, Higashi K, Taniguchi M, Nishikawa T, Tamamura H, Okimura T, Yamamoto I. Single photon emission CT images in a case of intraventricular neurocytoma. Ann Nucl Med. 1998.06; 12 (3): 161-164. ( PubMed )

Tamamura H, Waki M, Imai M, Otaka A, Ibuka T, Waki K, Miyamoto K, Matsumoto A, Murakami T, Nakashima H, Yamamoto N, Fujii N. Downsizing of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), with the maintenance of anti-HIV activity and solution structure. Bioorg Med Chem. 1998.04; 6 (4): 473-479. ( PubMed )

Tamamura H, Arakaki R, Funakoshi H, Imai M, Otaka A, Ibuka T, Nakashima H, Murakami T, Waki M, Matsumoto A, Yamamoto N, Fujii N. Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II). Bioorg Med Chem. 1998.02; 6 (2): 231-238. ( PubMed )

Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii. Convenient One-pot Synthesis of Cystine-Containing Peptides Using the Trimethylsilyl Chloride-Dimethylsulfoxide/Trifluoroacetic Acid System and its Application to the Synthesis of Bifunctional Anti-HIV Compounds. J. Chem. Soc., Perkin Trans.. 1998; 1 (3): 495-500.

Hiroaki Ohno, Kiyonori Ishii, Asami Honda, Hirokazu Tamamura, Nobutaka Fujii, Yoshiji Takemoto & Toshiro Ibuka. A 2,3-cis-Selective Synthesis of Aziridines Bearing a Vinyl Group from Allyl Methyl Carbonates and Allyl Mesylates. J. Chem. Soc., Perkin Trans.. 1998; 1 (22): 3703-3716.

Uenishi H, Iwanami N, Yamagishi H, Nakatani T, Kawasaki T, Tamamura H, Fujii N, Kuribayashi K. Induction of cross-reactivity in an endogenous viral peptide non-reactive to FBL-3 tumor-specific helper T-cell clones. Microbiol Immunol. 1998; 42 (7): 479-484. ( PubMed )

玉村　啓和・藤井　信孝. Coreceptorを標的とした抗エイズ薬剤の開発状況 日本ME学会雑誌BioMedical Engineering. 1998; 12 (10): 44-51.

Murakami T, Nakajima T, Koyanagi Y, Tachibana K, Fujii N, Tamamura H, Yoshida N, Waki M, Matsumoto A, Yoshie O, Kishimoto T, Yamamoto N, Nagasawa T. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med. 1997.10; 186 (8): 1389-1393. ( PubMed )

Ibuka T, Mimura N, Ohno H, Nakai K, Akaji M, Habashita H, Tamamura H, Miwa Y, Taga T, Fujii N, Yamamoto Y. Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an alpha,beta-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers. J Org Chem. 1997.05; 62 (9): 2982-2991. ( PubMed )

Toshiro Ibuka, Norio Mimura, Hiroshi Aoyama, Masako Akaji, Hiroaki Ohno, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto. A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-vinylaziridines over Their 2,3-trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosters. J. Org. Chem.. 1997; 62 (4): 999-1015.

Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake & Yoshinori Yamamoto. Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α, β-Unsaturated Ester Group. Tetrahedron. 1997; 53 (38): 12933-12946.

Hiromu Habashita, Takeshi Kawasaki, Masako Akaji, Hirokazu Tamamura, Tetsutaro Kimachi, Nobutaka Fujii & Toshiro Ibuka. One-Pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols. Tetrahedron Lett.. 1997; 38 (48): 8307-8310.

Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii & Toshiro Ibuka. Regio- and Stereoselectivity in Reactions of 2,3-cis- and trans-3-Alkyl-2-vinylaziridines with Organocopper Reagents: Importance of 2,3-cis-Stereochemistry in Controlling Selectivity. Tetrahedron Lett.. 1997; 38 (42): 7383-7386.

Tamamura H, Otaka A, Murakami T, Ibuka T, Sakano K, Waki M, Matsumoto A, Yamamoto N, Fujii N. An anti-HIV peptide, T22, forms a highly active complex with Zn(II). Biochem Biophys Res Commun. 1996.12; 229 (2): 648-652. ( PubMed, DOI )

Tamamura H, Ishihara T, Otaka A, Murakami T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N. Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance. Biochim Biophys Acta. 1996.11; 1298 (1): 37-44. ( PubMed )

Tamamura H, Otaka A, Murakami T, Ishihara T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N. Interaction of an anti-HIV peptide, T22, with gp120 and CD4. Biochem Biophys Res Commun. 1996.02; 219 (2): 555-559. ( PubMed, DOI )

Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka & Nobutaka Fujii. A Convenient One-pot Synthesis of Cystine-Containing Peptides from Protected Peptidyl Resins Using the Trimethylsilyl Chloride-Dimethylsulfoxide-Trifluoroacetic Acid System. J. Chem. Soc., Perkin Trans. (Perkin Commun.). 1996; 1 1911-1912.

Toshiro Ibuka, Kazuo Nakai, Masako Akaji, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto. An Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols in a One-pot Manner: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure N-Protected 1,2-Amino Alcohols. Tetrahedron. 1996; 52 11739-11752.

Nobutaka Fujii, Hiromu Habashita, Masako Akaji, Kazuo Nakai, Toshiro Ibuka, Masahiro Fujiwara, Hirokazu Tamamura & Yoshinori Yamamoto. A Simple One-pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols. J. Chem. Soc., Perkin Trans. (Perkin Commun.). 1996; 1 1996, 865-866.

Norio Mimura, Toshiro Ibuka, Masako Akaji, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto. An Unusual Thermodynamic Preference of Chiral N-Arylsulfonyl cis-3-Alkyl-2-vinylaziridines over Their trans-Isomers: Palladium(0)-Catalyzed Equilibration Reaction. J. Chem. Soc., Chem. Commun.. 1996; 351-352.

Toshiro Ibuka, Masako Akaji, Norio Mimura, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto. A Thermodynamic Preference of Chiral cis-γ,δ-Epimino-(E)-α,β-Unsaturated Esters over Other Stereoisomers: Synthetically Useful Pd(0)-Catalyzed Equilibrated Reactions of Aziridines Bearing an α,β-Unsaturated Ester Groups. Tetrahedron Lett.,. 1996; 37 2849-2852.

Michinori Waki, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Hirokazu Tamamura, Nobutaka Fujii, Tsutomu Murakami, Hideki Nakashima & Naoki Yamamoto. Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity. Chem. Lett.. 1996; 571-572.

Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M, et al.. A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes. J Virol. 1995.11; 69 (11): 6735-6741. ( PubMed )

Weeks BS, Nomizu M, Otaka A, Weston CA, Okusu A, Tamamura H, Yamamoto N, Fujii N. The synthetic [Tyr5,12,Lys7]-polyphemusin II peptide (T22) binds to the CD4 cell surface molecule. Biochem Biophys Res Commun. 1995.10; 215 (2): 626-631. ( PubMed, DOI )

Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N. Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity. Chem Pharm Bull (Tokyo). 1995.05; 43 (5): 853-858. ( PubMed )

Tamamura H, Otaka A, Nakamura J, Okubo K, Koide T, Ikeda K, Ibuka T, Fujii N. Disulfide bond-forming reaction using a dimethyl sulfoxide/aqueous HCl system and its application to regioselective two disulfide bond formation. Int J Pept Protein Res. 1995.04; 45 (4): 312-319. ( PubMed )

Tamamura H, Otaka A, Takada W, Terakawa Y, Yoshizawa H, Masuda M, Ibuka T, Murakami T, Nakashima H, Waki M, et al.. Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection. Chem Pharm Bull (Tokyo). 1995.01; 43 (1): 12-18. ( PubMed )

Akira Otaka, Kengo Miyoshi, Terrence R. Burke, Jr., Peter P. Roller, Hideki Kubota, Hirokazu Tamamura & Nobutaka Fujii. Synthesis and Application of N-Boc-L-2-amino-4-(diethylphosphono)-4, 4-difluorobutanoic acid for Solid-Phase Synthesis of Nonhydrolyzable Phosphoserine Peptide Analogs. Tetrahedron Lett.. 1995; 36 927-930.

Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto. A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alcohols. Tetrahedron Lett.. 1995; 36 6247-6250.

Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan & Yoshinori Yamamoto. Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions. J.Org.Chem.. 1995; 60 2044-2058.

Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto & Toshiro Ibuka. SN2' Ring Opening of Aziridines Bearing an α,β-Unsaturated Ester Group with Organocopper Reagents. A New Stereoselective Synthesis Route to (E)-Alkene Dipeptide Isosters. J. Chem. Soc., Perkin Trans.. 1995; 1 1359-1371.

Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke, Jr. & Peter P. Roller. Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides. J. Org. Chem.. 1995; 60 3967-3974.

Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke, Jr., Hirokazu Tamamura & Nobutaka Fujii. Practical Synthesis of Phosphopeptides using Dimethyl-protected Phosphoamino Acid Derivatives. J. Chem. Soc., Chem. Commun.. 1995; 387-389.

Otaka A, Tamamura H, Terakawa Y, Masuda M, Koide T, Murakami T, Nakashima H, Matsuzaki K, Miyajima K, Ibuka T, et al.. Molecular parameters for the anti-human immunodeficiency virus activity of T22 ([Tyr5,12, Lys7]-polyphemusin II). Biol Pharm Bull. 1994.12; 17 (12): 1669-1672. ( PubMed )

Tamamura H, Murakami T, Masuda M, Otaka A, Takada W, Ibuka T, Nakashima H, Waki M, Matsumoto A, Yamamoto N, et al.. Structure-activity relationships of an anti-HIV peptide, T22. Biochem Biophys Res Commun. 1994.12; 205 (3): 1729-1735. ( PubMed )

Shimizu T, Uenishi H, Teramura Y, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Yamagishi H. Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells. J Virol. 1994.12; 68 (12): 7704-7708. ( PubMed )

Weeks BS, Nomizu M, Otaka A, Weston CA, Okusu A, Tamamura H, Matsumoto A, Yamamoto N, Fujii N. Lymphocytes and promonocytes attach to the synthetic [Tyr5,12, Lys7]- polyphemusin II peptide. Biochem Biophys Res Commun. 1994.07; 202 (1): 470-475. ( PubMed )

Toshiro Ibuka, Keisuke Suzuki, Hiromu Habashita, Akira Otaka, Hirokazu Tamamura, Norio Mimura, Yoshihisa Miwa, Tooru Taga & Nobutaka Fujii. (E)-Stereoselective Synthesis of Vinylglycines from (R)-Serine via Organocopper-BF3 and Related Reagents. J. Chem. Soc., Chem. Commun.. 1994; 2151-2152.

Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Hirokazu Tamamura, Akira Otaka & Toshiro Ibuka. Synthesis of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks. Chem. Pharm. Bull.. 1994; 42 2241-2250.

Tamamura H, Kuroda M, Masuda M, Otaka A, Funakoshi S, Nakashima H, Yamamoto N, Waki M, Matsumoto A, Lancelin JM, et al.. A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance. Biochim Biophys Acta. 1993.05; 1163 (2): 209-216. ( PubMed )

Tamamura H, Ikoma R, Niwa M, Funakoshi S, Murakami T, Fujii N. Antimicrobial activity and conformation of tachyplesin I and its analogs. Chem Pharm Bull (Tokyo). 1993.05; 41 (5): 978-980. ( PubMed )

Tamamura H, Nakamura J, Noguchi K, Funakoshi S, Fujii N. Acceleration of the N alpha-deprotection rate by the addition of m-cresol to diluted methanesulfonic acid and its application to the Z(OMe)-based solid-phase syntheses of human pancreastatin-29 and magainin 1. Chem Pharm Bull (Tokyo). 1993.05; 41 (5): 954-957. ( PubMed )

Hirokazu Tamamura, Akira Otaka, Junko Nakamura, Kaori Okubo, Takaki Koide, Kyoko Ikeda & Nobutaka Fujii.. Disulfide Bond Formation in S-Acetamidomethyl Cysteine-Containing Peptides by the Combination of Silver Trifluoromethanesulfonate and Dimethylsulfoxide / Aqueous HCl. Tetrahedron Lett.. 1993; 34 4931-4934.

Toshiro Ibuka, Tooru Taga, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii, Yukiyasu Chounan, Hisao Nemoto & Yoshinori Yamamoto . Syn-SN2' Pathway in the Reaction of Certain γ-(Mesyloxy)-α,β-Enoates with RCu(CN)MgX.BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity. J. Org. Chem.. 1993; 58 1207-1214.

Masuda M, Nakashima H, Ueda T, Naba H, Ikoma R, Otaka A, Terakawa Y, Tamamura H, Ibuka T, Murakami T, et al.. A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II). Biochem Biophys Res Commun. 1992.12; 189 (2): 845-850. ( PubMed )

Miyasaka K, Funakoshi A, Kitani K, Tamamura H, Funakoshi S, Fujii N. Inhibitory effect of pancreastatin on pancreatic exocrine secretions. Pancreastatin inhibits central vagal nerve stimulation. Gastroenterology. 1990.12; 99 (6): 1751-1756. ( PubMed )

Tamamura H, Ohta M, Yoshizawa K, Ono Y, Funakoshi A, Miyasaka K, Tateishi K, Jimi A, Yajima H, Fujii N, et al.. Isolation and characterization of a tumor-derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48. Eur J Biochem. 1990.07; 191 (1): 33-39. ( PubMed )

Miyasaka K, Funakoshi A, Yasunami Y, Nakamura R, Kitani K, Tamamura H, Funakoshi S, Fujii N. Rat pancreastatin inhibits both pancreatic exocrine and endocrine secretions in rats. Regul Pept. 1990.04; 28 (2): 189-198. ( PubMed )

Miyasaka K, Funakoshi A, Kitani K, Tamamura H, Fujii N, Funakoshi S. The importance of the C-terminal amide structure of rat pancreastatin to inhibit pancreatic exocrine secretion. FEBS Lett. 1990.04; 263 (2): 279-280. ( PubMed )

Akihiro Funakoshi, Kyoko Miyasaka, Kenichi Kitani, Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Itsuro Nakano & Kazuhiko Tatemoto. Comparative Effects of Mammalian Pancreastatin on the Pancreatic Exocrine Secretion. Japanese J. Pysiol.. 1990; 39 901-905.

Tateishi K, Funakoshi A, Wakasugi H, Iguchi H, Shinozaki H, Abe M, Funakoshi S, Tamamura H, Yajima H, Matsuoka Y. Plasma pancreastatin-like immunoreactivity in various diseases. J Clin Endocrinol Metab. 1989.12; 69 (6): 1305-1308. ( PubMed )

Tateishi K, Funakoshi A, Jimi A, Funakoshi S, Tamamura H, Yajima H, Matsuoka Y. High plasma pancreastatinlike immunoreactivity in a patient with malignant insulinoma. Gastroenterology. 1989.11; 97 (5): 1313-1318. ( PubMed )

Funakoshi S, Tamamura H, Ohta M, Yoshizawa K, Funakoshi A, Miyasaka K, Tateishi K, Tatemoto K, Nakano I, Yajima H, et al.. Isolation and characterization of a tumor-derived human pancreastatin-related protein. Biochem Biophys Res Commun. 1989.10; 164 (1): 141-148. ( PubMed )

Funakoshi A, Jimi A, Yasunami Y, Tateishi K, Funakoshi S, Tamamura H, Yajima H. Bioactivity of human pancreastatin and its localization in pancreas. Biochem Biophys Res Commun. 1989.03; 159 (3): 913-918. ( PubMed )

Funakoshi A, Miyasaka K, Kitani K, Tamamura H, Funakoshi S, Yajima H. Bioactivity of synthetic C-terminal fragment of rat pancreastatin on endocrine pancreas. Biochem Biophys Res Commun. 1989.02; 158 (3): 844-849. ( PubMed )

Nobutaka Fujii, Akira Otaka, Toshihiro Watanabe, Akira Okamachi, Hirokazu Tamamura, Haruaki Yajima, Yoshimasa Inagaki, Motoyoshi Nomizu & Katsuhiko Asano. Silver Trifluoromethanesulphonate as an S-Deprotecting Reagent for the Synthesis of Cystine Peptides. J. Chem. Soc., Chem. Commun.. 1989; 283-284.

Funakoshi A, Miyasaka K, Nakamura R, Kitani K, Funakoshi S, Tamamura H, Fujii N, Yajima H. Bioactivity of synthetic human pancreastatin on exocrine pancreas. Biochem Biophys Res Commun. 1988.11; 156 (3): 1237-1242. ( PubMed )

Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Kumi Yoshizawa, Haruaki Yajima, Kyoko Miyasaka, Akihiro Funakoshi, Mitsuhiro Ohta, Yoshimasa Inagaki & Louis A. Carpino. Combination of a New Amide-precursor Reagent and Trimethylsilyl Bromide Deprotection for the Fmoc-based Solid Phase Synthesis of Human Pancreastatin and One of its Fragment. J. Chem. Soc., Chem. Commun.. 1988; 1588-1590.

Kobayakawa T, Narumi T, Tamamura H. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

Honda Y, Mizuguchi T, Hashimoto C, Taketomi S, Ohashi N, Nomura W, Tamamura H. Development of Dimeric Peptide Derivatives Based on gp41 Fragments as HIV-1 Fusion Inhibitors. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

Nomura W, Koseki T, Mizuguchi T, Tamamura H. Design and Synthesis of Trivalent CXCR4 Ligands Utilizing Polyproline Linkers. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

Fluorescnt-Based Orthogonal Sensing Methods for Double Ealuation in PKC Ligands Screening. Peptide Science 2009, 353-354. Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka， 2010

Caged DAG-Lactones for Study of Cellular Signaling in a Spatial-and Temporal^Specific Manner. Peptide Science 2009, 347-348. Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka， 2010

Synthesis and Evaluation of Artificial Antigen Peptide Based on the Trimeric Form of HIV Fusion Protein. Peptide Science 2009, 29-32. Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka， 2010

Small-Sized CD4 Mimics Targeted for Dynamic Supramolecular Mechanism of HIV-1 Entry. Peptide Science 2008, 297-298. Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka， 2009

Site-Selective Cytosine Methylation by a Split DNA Methylase. Peptide Science 2008, 491-492. Motoyoshi Nomizu (Eds.), The Japanese peptide Society, Osaka， 2009

Fluorescent Labeling for PKC delta C1b Domain and its Application to Sensing Biology. Peptide Science 2008, 61-62. Motoyoshi Nomizu (Eds.), The Japanese peptide Society, Osaka,， 2009

Development of Caged Diacylglycerol-lactone Derivatives and their Applications. Peptide Science 2008, 479-480. Motoyoshi Nomizu (Eds.), The Japanese peptide Society, Osaka， 2009

Fluorescent Labeled CXCR4 Speciic Ligand for Imaging and Fluorescence-Based Screening. Peptide Science 2008, 419-422. Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka， 2009

Development of Novel Tag-Probe for Fluorescent Imaging of Proteins in Living Cells. Peptide Science 2008, 443-444. Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka， 2009

Development of Inhibitory Peptides against HIV-1 Integrase. Peptide Science 2008, 315-316. Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka， 2009

Tamamura H. Development of anti-HIV agents targeting HIV-Gag proteins using in silico screening . The 37th European Peptide Symposium (EPS) & 14th International Peptide Symposium (IPS) Satellite Workshops, Applications of computational AI/ML in peptide research with a roadmap to peptide drug and material development 2024.08.30 Florence, Italy

Kobayakawa T, Azuma C, Yamamoto K , Tsuji K, Tamamura H. Convergent synthesis of peptidomimetic based on a chloroalkene dipeptide isostere and its application to inhibition against amyloid β aggregation. 14th International Peptide Symposium 2024.08.26 Florence, Italy

Miura Y, Tsuji K, Kobayakawa T, Kuwata T, Matsushita S, Tamamura H. Development of antibody drug conjugates as HIV entry inhibitors. 37th European peptide symposium 2024.08.26 Florence, Italy

Miura Y, Tsuji K, Kobayakawa T, Kuwata T, Matsushita S, Tamamura H. Development of hybrid-molecules as HIV entry inhibitors. 18th Chinese international peptide symposium 2024.07.01 Hong Kong

Tamamura H. Tripeptide-mimic Inhibitors against a Main Protease of SARS-CoV-2. The 18th Chinese International Peptide Symposium 2024.06.30 Hong Kong

Miura Y, Tsuji K, Kobayakawa T, Kuwata T, Matsushita S, Tamamura H. Antibody drug conjugates as HIV entry inhibitors. 27th Korean Peptide Protein Symposium 2024.06.24 Busan, South Korea

Tamamura H. Medicinal chemistry derived from peptides and peptidomimetics. The 10th Joint Symposium between IBB/TMDU and Chulalongkorn University on Biomedical Materials and Engineering 2024.01.19 Thailand

Takuya Kobayakawa, Chika Azuma, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura. Development of synthetic strategies for peptidomimetic based on a chloroalkene dipeptide isostere and its application to a cyclic peptide. The 15th International Kyoto Conference on New Aspects of Organic Chemistry 2023.11.21 Kyoto

Kohei Tsuji, Hirokazu Tamamura, Terrence R. Burke, Jr.. Utilization of a non-specific kinase inhibitor for the development of high-affinity bivalent polo-like kinase 1 polo-box domain inhibitors. The 60th Japanese Peptide Symposium 2023.11.10 Otsu

Takuya Kobayakawa, Chika Azuma, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura. Development of convergent synthesis for peptidomimetic based on a chloroalkene dipeptide isostere and its application to a cyclic peptide. The 60th Japanese Peptide Symposium 2023.11.08 Otsu

Kouki Shinohara, Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Yutaro Miura, Chika Azuma, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-activity relationship studies of novel SARS-CoV-2 main protease inhibitors with potent antiviral activity. The 60th Japanese Peptide Symposium 2023.11.08 Otsu

Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Combinational use of CD4 mimic with other anti-HIV agents and development of these hybrid molecules. 14th International Peptide Symposium 2023.10.17 Brisbane

Hirokazu Tamamura. Anti-SARS-CoV-2 Agents Inspired from HIV Researches. The 13th International Peptide Symposium/The 15th Australian Peptide Conference 2023.10.17 Brisbane

Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Double target inhibitors of HIV-1 entry based on hybrid molecules of CD4 mimics and HIV-1 gp41-related peptides. 26th Korean Peptide Protein Symposium 2023.07.04 Jeju

Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura . Design and Synthesis of SARS-CoV-2 Mpro Inhibitors Containing Flurine Atoms and Amide Surrogates. 26th KPPS Annual Symposium 2023.07.03 Jeju

Hirokazu Tamamura. Anti-SARS-CoV-2 Agents Based on HIV Researches. The Seoul National University (SNU) seminar 2023.06.30 Korea

Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura . Structure-Activity Relationship Studies of DAG-lactone Derivatives with HIV-1 Latancy Reversing Activity. 14th AFMC International Medicinal Chemistry Symposium 2023.06.27 Seoul

Hirokazu Tamamura. Development of potent and biostable inhibitors of the main protease of SARS-CoV-2 learned from HIV researches. The 14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023) 2023.06.27 Korea

Yutaro Miura, Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Hybrid molecules of CD4 mimic and HIV-1 fusion inhibitors. 14th AFMC International Medicinal Chemistry Symposium 2023.06.26 Seoul

Hirokazu Tamamura. Peptidomimetic-based Anti-SARS-CoV-2 Agents Learned from Anti-HIV Agents. The 17th Chinese International Peptide Symposium 2023.06.14 China

Hirokazu Tamamura. Development of Anti-SARS-CoV-2 Agents Learned from Anti-HIV Agents. The 19th Akabori Conference 2023: German-Japanese Symposium on Peptide Science 2023.05.19 Otsu

Hirokazu Tamamura. Use of synthetic peptides in infectious diseases research; vaccines, therapeutics and diagnostics. Discovery Research Platforms 2023.03.23 Online

Hirokazu Tamamura. Peptide-lead medicinal chemistry: from AIDS to COVID-19. The 9th Joint Symposium between IBB/TMDU and Chulalongkorn University on Biomedical Materials and Engineering 2023.01.23 Thailand

Kofi Baffour-Awuah Owusu , Kohei Tsuji , Takuya Kobayakawa , Youichi Suzuki, Hirokazu Tamamura. Development of SARS-CoV-2 Fusion Inhibitor Peptides Based on SARS-CoV-2 HR-2. The 39th Medicinal Chemistry Symposium 2022.11.23 Online

Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Youichi Suzuki, Hirokazu Tamamura. Development of fusion inhibitor peptides of SARS-CoV-2 learned from anti-HIV-1 agents. The 59th Japanese Peptide Symposium 2022.10.26 Sendai

Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Synthesis of inhibitors targeting the main protease of SARS-CoV-2 for therapeutics of COVID-19. The 59th Japanese Peptide Symposium 2022.10.26 Sendai

Yutaro Miura, Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ami Masuda, Nami Ohashi, Takeo Kuwata, Kazuhisa Yoshimura, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita, Hirokazu Tamamura. Pegylated CD4 mimics as HIV inhibitors. The 59th Japanese Peptide Symposium 2022.10.26 Sendai

Kouki Shinohara, Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Yutaro Miura, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-activity relationship studies of SARS-CoV-2 main protease inhibitors. The 59th Japanese Peptide Symposium 2022.10.26 Sendai

Kohei Tsuji, Rongyi Wang, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. Exploration of novel class anti-HIV-1 agents derived from a viral capsid protein. 36th European and 12th International Peptide Symposium 2022.08.29 Spain

Hirokazu Tamamura . From HIV to SARS-CoV-2: Fusion Inhibitors Based on Dimerization of HR2 Region Peptides. Frontiers in Peptide Science and Drug Discovery: A Scientific Symposium in Honor of Professor James P. Tam 2022.08.05 Singapore

Hirokazu Tamamura. Medicinal chemistry based on peptidomimetics. The 8th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2022.01.25 Online

Hirokazu Tamamura. Bivalent Ligands of GPCR as Molecular Measures, Bioprobes for Cancer Cells and Anti-cancer Agents. The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) 2021.12.20 Online

Hirokazu Tamamura, Takuya Kobayakawa, Kento Ebihara, Tsutomu Murakami, Kohei Tsuji. Development of HIV-1 fusion inhibitors based on dimeric derivatives of the C34 peptide and its peptidomimetics. The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) 2021.12.18 Online

Kohei Tsuji, Rongyi Wang, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. Explorative study in development of anti-HIV-1 peptides based on HIV-1 capsid protein segments. The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) 2021.12.15 Online

Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Development of protein kinase C activators for cure of HIV infectious diseases. The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) 2021.12.15 Online

Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ami Masuda, Nami Ohashi, Takeo Kuwata, Kazuhisa Yoshimura, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita, Hirokazu Tamamura. HIV entry inhibitors based on CD4 mimics with PEG units toward cure for HIV-infectious diseases. The 13th AFMC International Medicinal Chemistry Symposium 2021.12.02 Online

Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Structure-Activity Relationship Studies of Protein Kinase C Activators Derived from Diacylglycerol for Cure of HIV Infectious Diseases. The 13th AFMC International Medicinal Chemistry Symposium 2021.11.29 Online

Rongyi Wang, Kohei Tsuji, Yishan Liu, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. HYBRID MOLECULES OF CD4 MIMIC AND HIV-1 GP41-RELATED PEPTIDES AS FUSION INHIBITORS. The 58th Japanese Peptide Symposium 2021.10.22 Online

Kohei Tsuji, Takuya Kobayakawa, Kento Ebihara, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami, Hirokazu Tamamura. DIMERIZED SMALL MOLECULE HIV-1 FUSION INHIBITORS WITH DRAMATIC ENHANCEMENT OF THEIR ANTI-HIV-1 ACTIVITIES. The 58th Japanese Peptide Symposium 2021.10.21 Online

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura. A FRET-BASED ASSAY SYSTEM FOR PROTEIN KINASE C LIGAND SCREENING USING 1,2-DIACYLGLYCEROL-LACTONE DERIVATIVE. The 58th Japanese Peptide Symposium 2021.10.20 Online

Hirokazu Tamamura. Development of Anti-HIV and Anti-cancer Peptides. The 18th Akabori Conference: Japanese-German Symposium on Peptide Science 2021.03.08 Online

Kohei Tsuji. Kinase inhibitors for anti-cancer drugs. The 7th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2020.12.22 online (Thailand)

Hirokazu Tamamura. Mid-size drugs based on peptidomimetics. The 7th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2020.12.22 online (Thailand)

Hirokazu Tamamura. Bioimaging of GPCR dimers and its application to molecular probes for cancer cells. A3 Foresight & 5 Star Alliance Joint Workshop on Organic/Inorganic Hybrid Nano Materials and Bio Imaging 2020.12.03 online

Kaho Matsumoto, Takeo Kuwata, Zahid Hasan, Yu Kaku, Shashwata Biswas, Shokichi Takahama, Hirokazu Tamamura and Shuzo Matsushita. The CD4 mimetic compound YIR-821-mediated enhancement of the neutralization activities of plasma IgG against autologous isolates in vitro.. 21st Kumamoto AIDS Seminar 2020.11.11 online(Kumamoto)

Kofi Baffour-Awuah Owusu, Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Moemi Kaneko, Tsutomu Murakami, Hirokazu Tamamura. Exploratory studies on the development of anti-HIV-1 peptides based on HIV-1 capsid fragments. The 57th Japanese Peptide Symposium 2020.11.10 online(Tottori)

Kohei Tsuji, David Hyme, Buyong Ma, Ruth Nussinov, Hirokazu Tamamura,Terrence R. Burke, Jr.. Development of bivalent inhibitors of polo-like kinase 1 with great affinity enhancement. The 57th Japanese Peptide Symposium 2020.11.10 online (Tottori)

Wataru Nomura, Takumi Kamimura, Takuya Kobayakawa, Hirokazu Tamamura. Endogenous protein expression imaging by fluorogenic ZIP tag-probe system. The 57th Japanese Peptide Symposium 2020.11.10 online (Tottori)

Chika Azuma, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura. A convergent synthesis of chloroalkene dipeptide isosteres as peptidomimetics. The 57th Japanese Peptide Symposium 2020.11.09 online (Tottori)

Hirokazu Tamamura. Bivalent HIV-1 fusion inhibitors using peptidomimetics. 16th Chinese International Peptide Symposium 2020.09.25 online/Hefei, China (Keynote Speaker)

Hirokazu Tamamura . Bivalent Ligands of GPCR as Molecular Measures, Bioprobes for Cancer Cells and Anti-cancer Agents. The 7th SNU Symposium on Medicinal Chemistry 2020.02.14 Seoul, Korea

Hirokazu Tamamura . Peptide-lead medicinal chemistry: anti-cancer & HIV agents. The 6th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2020.01.14 Bangkok, Thailand

王容義、小早川拓也、金子萌美、Kofi Owusu、村上努、玉村啓和. カプシドタンパク質をもとにした細胞透過性抗HIV ペプチドの開発研究. 第37回メディシナルケミストリーシンポジウム 2019.11.28

村上努、海老原健人、小早川拓也、藤野真之、児玉栄一、玉村啓和. 二量体化HIV-1膜融合阻害剤の作用機構. 第33回日本エイズ学会学術集会・総会 2019.11.27 熊本

渡邉優基、小早川拓也、谷口敦彦、林良雄、玉村啓和. アミロイドβ凝集阻害活性を有する環状ペプチドへのCADI 導入の効果. 第37回メディシナルケミストリーシンポジウム 2019.11.27 東京

倉上真樹、小早川拓也、横山勝、村上努、金子萌美、小谷治、佐藤裕徳、玉村啓和. HIV-1 カプシドタンパク質の構造を基にした新規抗HIV-1 剤の構造活性相関研究. 第37回メディシナルケミストリーシンポジウム 2019.11.27 東京

東知佳、小早川拓也、玉村啓和. ペプチドミメティックを指向したクロロアルケン型ジペプチドイソスターの合成研究. 第37回メディシナルケミストリーシンポジウム 2019.11.27 東京

海老原健人、川田拓馬、小早川拓也、村上努、玉村啓和. HIV-1 膜融合を標的とする低分子化合物を基にした二価型膜融合阻害剤の創製. 第37回メディシナルケミストリーシンポジウム 2019.11.27 東京

Elucidation of mechanism of HIV-1 fusion inhibitors developed by dimerization strategy. 第67回 日本ウイルス学会学術集会 2019.10.29 東京

松田幸樹、小早川拓也、土屋亮人、服部真一朗、潟永博之、吉村和久、岡慎一、遠藤泰之、玉村啓和、満屋裕明、前田賢次. HIV潜伏感染再活性化を介してリザーバー細胞にアポトーシスを誘導するPKC活性化剤の同定. 第67回 日本ウイルス学会学術集会 2019.10.29

Wataru Nomura, Takumi Kamimura, Takuya Kobayakawa, Hirokazu Tamamura. Fluorogenic ZIP tag-probe system for fluorescent imaging of endogenous protein expression. 第56回ペプチド討論会 2019.10.25

Rongyi Wang, Takuya Kobayakawa, Moemi Kaneko, Kofi Owusu, Tsutomu Murakami, Hirokazu Tamamura. Development of cell-permeable anti-HIV peptides based on capsid proteins. 第56回ペプチド討論会 2019.10.25

Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Development of a nanoBRET-based sensitive screening method to search for chemokine receptor CXCR4 ligands. 第56回ペプチド討論会 2019.10.25 東京

Yuki Watanabe, Takuya Kobayakawa, Atsuhiko Taniguchi, Yoshio Hayashi, Hirokazu Tamamura. Development of peptidomimetic inhibitors for aggregation of amyloid beta. 2019.10.23 東京

Kento Ebihara, Yuzuna Honda, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. Development of HIV-1 fusion inhibitors based on the C34 dimer derived from an HIV-1 envelope protein gp41. 第56回ペプチド討論会 2019.10.23 東京

Masaki Kurakami, Takuya Kobayakawa, Masaru Yokoyama, Tsutomu Murakami, Moemi Kaneko, Osamu Kotani, Hironori Sato, Hirokazu Tamamura. Structure-activity relationship studies of small molecular anti-HIV-1 compounds targeting a dipeptide site of HIV-1 capsid proteins. 第56回ペプチド討論会 2019.10.23 東京

Takuya Kobayakawa, Hirokazu Tamamura. Development of chemical synthesis for peptidomimetic based on a chloroalkene dipeptide isostere and its application to a cyclic peptide. 第56回ペプチド討論会 2019.10.23 東京

Hirokazu Tamamura. Elucidation of a dimerization state of a GPCR and its application to molecular probes for cancer cells. The 2019 International Conference on Molecular Imaging and Minimally Invasive Therapy (2019 MIMIT) 2019.10.18 Beijing, China

Hirokazu Tamamura. Development of bivalent ligands of GPCR and their application to molecular probes for cancer cells and anti-cancer agents. 7th Modern Solid Phase Synthesis & Its Applications Symposium 2019.09.07 Palm Cove, Australia

Tamamura H. Peptide drug discovery. 25th Peptide Forum – International Forum on Peptides in Drug Discovery - /Satellite Symposium of 10th International Peptide Symposium 2018.12.10 Tokyo, Japan

Wataru Nomura , Takumi Kamimura, Daisuke Matsumoto, Takuya Kobayakawa, Hirokazu Tamamura. Fluorogenic and genetically encodable tag-probe system for in-cell imaging of protein synthesis . 10th International Peptide Symposium／55th Japanese Peptide Symposium 2018.12.05 Kyoto, Japan

小早川 拓也, 玉村 啓和. Synthetic Strategy of Peptidomimetic Based on Chloroalkene Dipeptide Isoteres and Its Biological Application. 10th International Peptide Symposium／55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

Tamamura H. Peptidomimetic-based mid-size drugs: anti-cancer and anti-HIV agents. 10th International Peptide Symposium／55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

Kento Ebihara, Yuzuna Honda, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. HIV-1 Fusion Inhibitors Based on gp41-C34 dimers. 10th International Peptide Symposium／55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

Takuya Kobayakawa, Kohei Takahashi, Ami Masuda, Shigeyoshi Harada, Tomoyuki Miura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura. Structure‐activity relationship studies of CD4 mimic molecules for targeting an envelope protein gp120 on HIV-1. 19th Kumamoto AIDS Seminar 2018.11.06 Kumamoto, Japan

Takuya Kobayakawa, Kohei Takahashi, Ami Masuda, Shigeyoshi Harada, Tomoyuki Miura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura. Structure‐activity relationship studies of CD4 mimic molecules for targeting an envelope protein gp120 on HIV-1. 19th Kumamoto AIDS Seminar 2018.11.06 Kumamoto, Japan

Tsutomu Murakami, Kento Ebihara, Masayuki Fujino, Yuzuna Honda, Takuya Kobayakawa, Wataru Nomura, Hirokazu Tamamura. Development of new membrane fusion inhibitors against HIV-1 by “dimerization” strategy. 第66回日本ウイルス学会学術集会 2018.10.28 京都

Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Development of a new NanoBRET assay system for CXCR4 ligands and their Structure-activity relationship studies. Frontiers 2018 Symposium (EPFL/TMDU/UTokyo Joint Symposium) 2018.09.21 Lausanne, Switzerland

Tamamura H. Peptidomimetic-based mid-size drugs: anti-cancer and anti-HIV agents. Frontiers 2018 Symposium (EPFL/TMDU/UTokyo Joint Symposium) 2018.09.21 Lausanne,Switzerland

Daisuke Matsumoto, Wataru Nomura, Hirokazu Tamamura. Split site-specific nucleases for controlled genome editing by chemicals. Frontiers 2018 Symposium (EPFL/TMDU/UTokyo Joint Symposium) 2018.09.21 Lausanne, Switzerland

サキヤマ・マクスウェル, 野村 渉, 小早川 拓也, 玉村 啓和. Development of NanoBRET assay system in living cells for structure-activity relationship studies of CXCR4 ligands. 第62回 日本薬学会 関東支部大会 2018.09.15 東京

Tamamura H. Synthesis of Peptidomimetics Based on Chloroalkene Dipeptide Isosteres and Their Biological Application. The 17th Akabori Conference 2018: German- Japanese Symposium on Peptide Science 2018.09.04 Lindau,Germany

Tamamura H. HIV-1 fusion inhibitors based on the C34 dimers derived from gp41. 15th Chinese International Peptide Symposium 2018.07.04 Shenzhen,China

Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Development of NanoBRET assay system in living cells to search potent CXCR4 ligands. 日本ケミカルバイオロジー学会第13回年会 2018.06.13 東京

Tsutomu Murakami, Masayuki Fujino, Masaru Yokoyama, Takuya Kobayakawa, Hiroaki Takeuchi, Takao Masuda, Osamu Kotani, Hirokazu Tamamura, Hironori Sato. Biological and molecular characterization of a novel anti-HIV-1 compound created by in silico design and de novo organic synthesis. Cold Spring Harbor Laboratory Meetings & Courses, Retrovirus Meeting 2018.05.23 Cold Spring Harbor, United States of America

サキヤマ マクスウエル, 野村 渉, 玉村 啓和. CXCR4 リガンド候補化合物の探索を指向した高感 度スクリーニング手法の開発. 日本薬学会第138年会 2018.03.26 石川

Nomura W, Matsumoto D, Sugii T, Kobayakawa T, Tamamura H. Differential regulation of endogenous genes in an orthogonal manner by distinct chemically inducible systems. International Conference on Epigenetics and Bioengineering 2017.12.13 Miami, USA

Tamamura H. Synthesis of chloroalkene dipeptide isosteres as peptidomimetics and their biological application. 12th Australian Peptide Conference 2017 2017.10.17 Noosa, Australia

Toyama K, Nomura W, Tamamura T. Functional evaluation of intracellular delivery peptides based on the EGF receptor dimerization arm sequences. 12th Australian Peptide Conference 2017 2017.10.16 Noosa, Australia

Nomura W, Matsumoto D, Hashimoto T, Sugii T, Tamamura H. Development of chemical-inducible artificial transcription factors based on sequence-specific DNA binders. the 254th ACS National Meeting and Exposition 2017.08.20 Washington DC, USA

Ohashi N, Harada S, Irahara Y, Ishida Y, Konno K, Kobayakawa T, Nomura W, Matsushita S, Yoshimura K, Tamamura H. CD4 Mimics for Enhancement of Activity of HIV Neutralizing Antibodies. The 11th AFMC International Medicinal Chemistry Symposium 2017.07.24 Melbourne, Australia

Tamamura H. Rigid bivalent ligands of the chemokine receptor CXCR4 and their anti-cancer metastasis activity. KCS Biochemistry Division Summer Workshop 2017.06.27 Jeju, Korea

Ebihara K, Honda Y, Nomura W, Murakami T, Tamamura H. Development of HIV-1 fusion inhibitors based on the C34 dimers derived from gp41. The 21st Korean Peptide Protein Society Symposium 2017.06.25 Jeju, Korea

Nomura W, Tanaka T, Aoki T, Tamamura H. Bivalent Ligands of the Chemokine Receptor CXCR4 with Polyproline Linkers and Their Anti-chemotactic Activity. The 25th American Peptide Symposium and the 9th International Peptide Symposium 2017.06.21 Whistler, Canada

Kobayakawa T, Tamamura H. Development of Synthetic Methods for Chloroalkene Dipeptide Isosteres and Their Applications. The 25th American Peptide Symposium and the 9th International Peptide Symposium 2017.06.19 Whistler, Canada

Nomura W, Sugii T, Tamamura H. Chemical-inducible artificial transcription factors based on sequence-specificity of TALE and dCas9. Keystone Symposia Precision Genome Engineering 2017.01.08 Breckenridge, USA

HashimotoT, Nomura W, Ohura I, Tamamura H. Improved split DNA methylase activity by optimization of assembly on target sites. Keystone Symposia Precision Genome Engineering 2017.01.08 Breckenridge, USA

Matsumoto D, Nomura W, Tamamura H. Controllable genome editing by chemically inducible split site-specific nucleases. Keystone Symposia Precision Genome Engineering 2017.01.08 Breckenridge, USA

Tamamura H. Medicinal Chemistry/Peptide & Protein Chemistry/Chemical Biology- Peptidomimetic-based Mid-Size Drugs –. The 3rd Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering, Chulalongkorn University 2016.12.15 Bangkok, Thailand

Nomura W, Tamamura H. Design of synthetic peptides mimicking dynamic supramolecular mechanisms in HIV fusion as antigens and inhibitors against trimer-form of gp41. Antibody Engineering & Therapeutics 2016.12.12 San Diego, California

Tamamura H. Mid-size Drugs: Peptide-lead Anti-HIV Agents. The 2nd Peptides and Proteins Symposium Singapore 2016.12.09 Singapore, Singapore

Kobayakawa T, Matsuzaki Y, Nomura W, Hozumi K, Nomizu M and Tamamura H. Development of Chloroalkene Dipeptide Isosteres as Peptidomimetics and Their Application. 2016.12.08 Singapore, Singapore

Tamamura H. Mid-sized drugs based on peptide mimetics. 15th Surugadai International Symposium 2016.11.29 Tokyo, Japan

Takano H, Nomura W, Tamamura H. Development of a Hydrophilic Caged PKC Ligand with an 8-Azacoumarin Photolabile Protecting Group for the Precise Photocontrol of PKC Activation. 34th European Peptide Symposium 2016 & 8th International Peptide Symposium 2016.09.08 Leipzig, Germany

Toyama K, Mizuguchi T, Nomura W, Tamamura H. Functional Evaluation of Fluorescein-Labeled Peptides Based on the EGF Receptor Dimerization Arm Sequences. 34th European Peptide Symposium 2016 & 8th International Peptide Symposium 2016.09.08 Leipzig, Germany

Tamamura H. Mid-Size Drugs: Dimer& Trimer Mimics of HIV-gp41 Peptides as Fusion Inhibitors. 34th European Peptide Symposium 2016 & 8th International Peptide Symposium 2016.09.05 Leipzig, Germany

Kobayakawa T, Tamamura H. Development of synthetic methodology of chloroalkene-type dipeptide isosteres for peptidomimetics. 252nd American Chemical Society National Meeting 2016.08.23 Philadelphia, USA

Nomura W, Ohashi N, Tamamura H. Protein Dynamics Imaging Using Tag-probe Systems. The 14th Chinese International Peptide Symposium & the 5th Asia-Pacific International Peptide Symposium 2016.07.06 Nanjing, China

Miyaki D, Mizuguchi T, Nomura T, Takahashi D, Tamamura H. Synthesis of Anti-Integrase Stapled Peptides with a Soluble Linker. The 14th Chinese International Peptide Symposium & the 5th Asia-Pacific International Peptide Symposium 2016.07.06 Nanjing, China

Tamamura H. Mid-Size Drugs: HIV Fusion Inhibitors Based on the C34 Dimer/Trimer Derived from gp41. The 20th Korean Peptide Protein Society Symposium 2016.06.24 Yangyang, Korea

Toyama K, Mizuguchi T, Nomura W, and Tamamura H. Development of New Fluorescein-Labeled Peptides with Inhibitory Effect on the EGF Receptor Activation. The 20th Korean Peptide Protein Society Symposium 2016.06.24 Yangyang, Korea

Nomura W, Sugii T, Tamamura H. Chemically-inducible gene regulation system utilizing sequence-specificity of TALE and dCas9. FASEB SRC: Genome Engineering: Cutting-Edge Research and Applications 2016.06.08 Lisbon、Portugal

Nomura W, Ohashi N, Tamamura H. Tag-probe Systems for Protein Dynamics Imaging. The 16th Akabori Conference: Japanese-German Symposium on Peptide Science 2016.05.24 Kobe, Japan

Nomura W, Ohashi N, Tamamura H. In-cell fluorogenic tag-probe system for protein localization and dynamics imaging. 251st American Chemical Society National Meeting 2016.03.17 San Diego, USA

Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Development of water-soluble and highly photosensitive 8-azacoumarin-4-ylmethyl-type photolabile-protecting groups for dynamic analysis of bioactive molecules. 251st American Chemical Society National Meeting 2016.03.16 San Diego, USA

Nomura W, Masuda A, Tamamura H. Efficient conversion of genomic promoter region by genome engineering systems. Pacifichem 2015 2015.12.15 Honolulu, USA

Tamamura H. Multivalent ligands for CXCR4 with polyproline linkers showing specific recognition for its expression. The 7th International Peptide Symposium 2015.12.11 Singapore, Singapore

Tamamura H. Multivalent ligands showing specific recognition for CXCR4 expression. The Seventh Peptide Engineering Meeting (PEM7) 2015.12.07 Pune, India

谷田部夏香, 松本大地, 橋本知恵, 藤野真之, 水口貴章, 大橋南美, 野村　渉, 村上　努, 玉村啓和. HIV-1カプシドタンパク質由来ペプチドライブラリーの構築と阻害剤の創出. 第29回日本エイズ学会学術集会・総会 2015.11.30

宮木大輔, 水口貴章, 村上　努, 野村　渉, 玉村啓和. HIV-1遺伝子産物ペプチドを基とするインテグラーゼ阻害剤の構造活性相関研究. 第29回日本エイズ学会学術集会・総会 2015.11.30 東京

石田有佑, 水口貴章, 原田恵嘉, 三浦智行, 小谷みさと, 山田裕子, 苛原　優, 　野村　渉, 松下修三, 吉村和久, 玉村啓和. 新規CD4ミミックの創製と薬物動態解析. 第29回日本エイズ学会学術集会・総会 2015.11.30 東京

水口貴章, 苛原　優, 原田恵嘉, 三浦智行, 小谷みさと, 石田有佑, 山田裕子, 大橋南美, 野村　渉, 松下修三, 吉村和久, 玉村啓和. 薬物動態の改善を志向した低分子CD4ミミックの創製研究. 第29回日本エイズ学会学術集会・総会 2015.11.30 東京

Misato Kotani, Yu Irahara, Yusuke Ishida, Shigeyoshi Harada, Nami Ohashi, Yuko Yamada, Takaaki Mizuguchi, Tomoyuki Miura, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura. Development of small CD4 mimic molecules with a mono-cyclohexyl type group targeting HIV-1 gp120. 第29回日本エイズ学会学術集会・総会 2015.11.30 東京

本田柚子奈, 野村　渉, 藤野真之, 村上　努, 玉村啓和. HIV外被タンパク質gp41の断片ペプチドC34を基にした二量化膜融合阻害剤の創製. 第29回日本エイズ学会学術集会・総会 2015.11.30 東京

小早川拓也, 玉村啓和. ペプチド結合の基底状態模倣体を指向したクロロアルケン型ジペプチドイソスターの創製研究. 第33回メディシナルケミストリーシンポジウム 2015.11.26 幕張

石田有佑, 水口貴章, 原田恵嘉, 三浦智行, 小谷みさと, 山田裕子, 苛原　優, 野村　渉, 松下修三, 吉村和久, 玉村啓和. カテコール誘導体を基盤とした新規CD4ミミックの創製と薬物動態解析. 第33回メディシナルケミストリーシンポジウム 2015.11.26 幕張

水口貴章, 外山　桂, 石田有佑, 野村　渉, 玉村啓和. 上皮成長因子受容体の「二量体化アーム」を基盤とした新規抗がん薬開発に向けた環状ペプチドに関する研究. 第33回メディシナルケミストリーシンポジウム 2015.11.26 幕張

Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Hirokazu Tamamura, Tsutomu Murakami. Dimerization of C34 Derivatives with C-Terminal Disulfide Bridge and Addition of an N-Terminal GCGG Markedly Enhance anti-HIV-1 Activity. 第63回日本ウイルス学会学術集会 2015.11.22 福岡

Nomura W, Masuda A, Tamamura H. Simultaneous digestion by site-specific nucleases for efficient gene deletion: Study of hTERT promoter function. Conference on Transposition and Genome Engineering 2015 2015.11.17 Nara. Japan

Takaaki Mizuguchi, Kei Toyama, Yusuke Ishida, Wataru Nomura, Hirokazu Tamamura. Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization. 第52回ペプチド討論会 2015.11.16

Takayoshi Higashi, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura. Development of a Highly Sensitive Assay Method for Ligand Binding with a Fluorescent Labeled PKC δC1b Domain. 第52回ペプチド討論会 2015.11.16 平塚

Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Stereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. 第52回ペプチド討論会 2015.11.16 平塚

Hikaru Takano, Tetsuo Narumi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura. Improvement of Photolytic Efficiency of the 8-Azacoumarin Chromophore Induced by Iodine Functionalization. 第52回ペプチド討論会 2015.11.16 平塚

Kei Toyama, Takaaki Mizuguchi, Yusuke Ishida, Wataru Nomura, Hirokazu Tamamura. Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor. 第52回ペプチド討論会 2015.11.16 平塚

Nami Ohashi, Wataru Nomura, Natsuki Minato, Hirokazu Tamamura. FRET-Based Binding Assay for PKC Ligands with Small Fluorescent Dyes. 第52回ペプチド討論会 2015.11.16

Yuzuna Honda, Wataru Nomura, Masayuki Fujino, Tsutomu Murakami, Hirokazu Tamamura. Development of Dimeric Inhibitors Derived from a gp41 Fragment against HIV-1 Membrane Fusion Utilizing an Intermolecular Disulfide Bridge. 第52回ペプチド討論会 2015.11.16 平塚

Wataru Nomura, Akemi Masuda, Hirokazu Tamamura. Genome Deletion by ZFN and CRISPR-Cas Targeting Promoter Region for Analysis of hTERT Function. 「細胞を創る」研究会8.0 2015.11.12 吹田

Nomura W, Honda Y, Mizuguchi T, Tamamura H. Peptidomimetic-based Mid-size Drug Research: Anti-HIV Agents. The 10th AFMC International Medicinal Chemistry Symposium 2015.10.19 Jeju, Korea

Mizuguchi T, Ohashi N, Nomura W, Murakami T, Tamamura H. An anti-HIV assay method for cell-penetrating peptides using chloroquine and identification of inhibitory peptides derived from matrix proteins. The 16th Kumamoto AIDS Seminar 2015.10.08 Kumamoto, Japan

Kotani M, Irahara Y, Ishida Y, Harada S, Ohashi N, Yamada Y, Mizuguchi T, Miura T, Nomura W, Matsushita S, Yoshimura K, Tamamura H. New design of small CD4 mimic molecules targeting HIV-1 gp120. 2015.10.07 Kumamoto, Japan

Honda Y, Nomura W, Fujino M, Murakami T, Tamamura H. Development of dimeric inhibitors against HIV-1 fusion utilizing disulfide bonds derived from gp41 fragment peptides. The 16th Kumamoto AIDS Seminar 2015.10.07 Kumamoto, Japan

Tamamura H. Development of peptide-lead anti-HIV agents and chemical biology. Department of Pharmacology and Experimental Neuroscience – Seminar Series in University of Nebraska Medical Center 2015.10.02 Omaha, USA

Ohashi N, Nomura W, Minato N, Tamamura H. Development of a FRET Based PKC Ligand Screening Method. The 19th Korean Peptide Protein Symposium 2015.07.06 Taean, Korea

Honda Y, Nomura W, Fujino M, Murakami T, Tamamura H. Dimerization of C34 Derivatives with C-Terminal Disulfide Bridge and the Addition of an N-Terminal GCGG Sequence Extremely Increase HIV-1 Inhibitory Activity. The 19th Korean Peptide Protein Symposium 2015.07.06 Taean, Korea

Tamamura H. Development of anti-HIV agents and prevention of HIV infection. Taipei Medical University-Tokyo Medical and Dental University Joint Symposium 2015: Preventive Medicine and Dentistry 2015.05.14 Tokyo, Japan

Nomura W, Masuda A, Tamamura H.. Enhanced Gene Disruption by Simultaneous Digestion of ZFN or CRISPR/Cas System at hTERT Promoter Region. FASEB SRC "Genome Engineering Cutting-Edge Research and Applications” . FASEB SRC "Genome Engineering Cutting-Edge Research and Applications" 2014

Mizuguchi T, Yamazaki Y, Kobayashi K, Ooe H, Iida M, Ninomiya R, Saito K, Akaji K, Tamamura H.. Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide against EGF Receptor Dimerization.. The 51th Japanese Peptide Symposium 2014

Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Development of 8-Azacoumarin-4-ylmethyl-type Photolabile Protecting Groups Based on Amide-alkene Isosterism.. The 51th Japanese Peptide Symposium 2014

Kobayakawa T, Narumi T, Tamamura H. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres. The 51th Japanese Peptide Symposium 2014

Honda Y, Mizuguchi T, Nomura W, Tamamura H. Development of Dimeric Peptide Derivatives Based on gp41 Fragments as HIV-1 Fusion Inhibitors. The 51th Japanese Peptide Symposium 2014

Nomura W, Koseki T, Mizuguchi T, Tamamura H. Design and Synthesis of Trivalent CXCR4 Ligands Utilizing Polyproline Linkers. The 51th Japanese Peptide Symposium 2014

Kotani M, Hirota Y, Irahara Y, Harada S, Yamada Y, Ohashi N, Mizuguchi T, Nomura W, Matsushita S, Yoshimura K, Tamamura H.. Structure-activity Relationship Studies of CD4 Mimic Molecules.. The 15h Kumamoto AIDS Seminar. 2014

Irahara Y, Kotani M, Harada S, Narumi T, Yamada Y, Hirota Y, Ohashi N, Mizuguchi T, Nomura W, Matsushita S, Yoshimura K, Tamamura H.. A New Type of Small CD4 Mimic Molecules Targeting an HIV Envelope Protein gp120.. The 15h Kumamoto AIDS Seminar. 2014

Yamada Y, Hashimoto C, Otsuki H, Hirota Y, Yoshimura K, Harada S, Ohashi N, Mizuguchi T, Nomura W, Miura T, Igarashi T, Matsushita S, Tamamura H.. A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics... The 15h Kumamoto AIDS Seminar. 2014

Nomura W, Métifiot M, Ohashi N, Fujino M, Mizuguchi T, Yamamoto N, Pommier Y, Komano JA, Murakami T, Tamamura H.. Cell-permeable Stapled Peptides with Integrase Inhibitory Activity Derived from HIV Gene Products.. The 15h Kumamoto AIDS Seminar. 2014

Nomura W, Hashimoto C, Fujino M, Murakami T, Ohashi N, Tamamura H.. Multimerized Peptides Derived from the C-Terminal Region of HIV-1 gp41 as Fusion Inhibitors.. The 33rd European Peptide Society Symposium. 2014

Nomura W, Masuda A, Tamamura H.. Efficient Gene Disruption at hTERT Promoter Region by Simultaneous Digestion by Pairs of ZFNs or Guide RNAs of CRISPR/Cas System.. The 28th annual symposium of protein society. 2014

Nomura W, Masuda A, Tamamura H.. Enhanced Gene Disruption at Specific Promoter Region by Simultaneous Digestion of ZFN or CRISPR/Cas System.. The Synthetic Biology: Engineering, Evolution & Design (SEED) conference 2014

Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells. 22nd American Peptide Symposium 2011

Design and Synthesis of Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins. 22nd American Peptide Symposium 2011

Studies for Optimum Design of Artificial Zinc Finger Recombinases by Evaluation of Effects of DNA Binding Affinity and Linker Components on Recombination Efficiency. 22nd American Peptide Symposium 2011

Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins. 22nd American Peptide Symposium 2011

Identification of Anti-HIV Peptides Derived from Matrix Proteins. ACS Meeting Fall2011 2011

Synthesis of C1b Domains of Protein Kinase C Having Solvatochromism and their Application to Bio-sensing. The 9th Australian Peptide Conference 2011

Sequence-Specific Recombination Enabled by a Pair of Zinc Finger Recombinases. The 9th Australian Peptide Conference 2011

Synthetic Studies on (Z) and (E)-Chloroalkene Skeltons As Amide Bond Equivalents. 8th AFMC International Medicinal Chemistry Symposium 2011

SAR Studies of Small Molecular CD4 Mimics Targeting the HIV Entry Mechanism. 8th AFMC International Medicinal Chemistry Symposium 2011

N-(Benzoyloxy)sulfonamides-Mediated Aziridination of α, β-Unsaturated Enones. 8th AFMC International Medicinal Chemistry Symposium 2011

Development of Artificial Recombinases for Genome Editing. 8th AFMC International Medicinal Chemistry Symposium 2011

Synthetic Antigens for Induction of Structure-Specific Antibodies against Trimer-Form of gp41. 8th AFMC International Medicinal Chemistry Symposiu 2011

CXCR4-Derived Peptides Targeting AIDS Vaccines. 8th AFMC International Medicinal Chemistry Symposium 2011

Several HIV Inhibitors Targeting Entry, Fusion, Integrase and Matrix. 8th AFMC International Medicinal Chemistry Symposium 2011

Development of Photochemically Removable Protecting Groups in Hydrophilic Environments: Synthesis and Photochemical Property of 8-Azacoumarins. 8th AFMC International Medicinal Chemistry Symposium 2011

Application of Stimulus-responsive Amino Acid to Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins. 8th AFMC International Medicinal Chemistry Symposium 2011

Development of Small CD4 Mimic Molecules that Induce Conformational Changes in gp120. 11th KUMAMOTO AIDS Seminer-GCOE Joint International Symposium 2010

Kinetic Analysis of Split DNA Methylase in DNA Recognition and Methylation. 2010 International Chemical Congress of Pacific Basin Societies 2010

Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products. Tamamura H.. 11th KUMAMOTO AIDS Seminer -GCOE Joint International Symposium 2010

Synthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines. 5th International Peptide Symposium 2010

Structure-Activity Relationships of CXCR4 Antagonists Having the Dipicolylamine/Azamacro- Cyclic-Metal Complex Structures.. 11th KUMAMOTO AIDS Seminer-GCOE Joint International Symposium 2010

Strategy to Overcome Neutralization Resistance of HIV-1 Primary Isolates. 11th KUMAMOTO AIDS Seminer-GCOE Joint International Symposium 2010

Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products. 11th KUMAMOTO AIDS Seminer -GCOE Joint International Symposium 2010

Effects of DNA binding and linker length on recombination of artificial zinc-finger recombinase. The 37th International Symposium on Nucleic Acids Chemistry 2010 2010

Anti-HIV Inhibitors and AIDS Vaccines.. International Summer Program 2010 2010

Elucidation of a Dimerization State of a Chemokine Receptor CXCR4 via Chemical Biology Approach Utilizing Novel Bivalent Ligands with Rigid Polyproline Linkers. The 13th Akabori Conference Leipzig 2010: Japanese-German Symposium on Peptide Science 2010

Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells. 5th International Peptide Symposium 2010

Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker. 5th International Peptide Symposium 2010

α,α-Dicholoroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation of α-Peptide α-Ketoacids. 5th International Peptide Symposium 2010