Graduating School 【 display / non-display 】
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Kyoto University, Faculty of Pharmaceutical Science, 1988, Graduated
Campus Career 【 display / non-display 】
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2015.04-NowTokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biomolecular Chemistry， Medicinal Chemistry， Professor
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2014.04-2015.03Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Molecular Biomedicine， Professor
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2014.01-2015.03Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Medicinal Chemistry， Professor
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2015.04-NowTokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Medicinal Chemistry， Professor
Published Papers & Misc 【 display / non-display 】
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Kobayakawa T, Azuma C, Watanabe Y, Sawamura S, Taniguchi A, Hayashi Y, Tsuji K, Tamamura H. Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. The Journal of organic chemistry. 2021.03; ( PubMed, DOI )
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Kobayakawa T, Yokoyama M, Tsuji K, Fujino M, Kurakami M, Boku S, Nakayama M, Kaneko M, Ohashi N, Kotani O, Murakami T, Sato H, Tamamura H. Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins. Biomolecules. 2021.02; 11 (2): ( PubMed, DOI )
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Kobayakawa T, Tsuji K, Konno K, Himeno A, Masuda A, Yang T, Takahashi K, Ishida Y, Ohashi N, Kuwata T, Matsumoto K, Yoshimura K, Sakawaki H, Miura T, Harada S, Matsushita S, Tamamura H. Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of medicinal chemistry. 2021.01; ( PubMed, DOI )
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Tsuji K, Wang R, Kobayakawa T, Owusu KB, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H. Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & medicinal chemistry. 2020.12; 30 115923. ( PubMed, DOI )
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Miller SE, Tsuji K, Abrams RPM, Burke TR Jr, Schneider JP. Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein-Protein Interactions. Journal of the American Chemical Society. 2020.11; ( PubMed, DOI )
Books etc 【 display / non-display 】
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The Frontier of Peptide Drug Discovery. 2019.05 (ISBN : 978-4-7813-1417-4)
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Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi. Mid-size Drugs Based on Peptides and Peptidomimetics. 2018.01 (ISBN : 978-981-10-7691-6)
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Ohashi N, Tamamura H. “Peptide-derived mid-sized anti-HIV agents” In “Amino Acids, Peptides and Proteins,” ed. by Maxim Ryadnov and Ferenc Hudecz, The Royal Society of Chemistry, Cambridge CB4 0WF, UK, vol. 41. 2017.01
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Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. tereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. The Japanese Peptide Society， 2016.03
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Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Development of 8-Azacoumarin-4-ylmethyl-type Photolabile Protecting Groups Based on Amide-Alkene Isosterism. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015
Conference Activities & Talks 【 display / non-display 】
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Kohei Tsuji. Kinase inhibitors for anti-cancer drugs. The 7th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2020.12.22 online (Thailand)
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Hirokazu Tamamura. Mid-size drugs based on peptidomimetics. The 7th Joint Symposium between Chulalongkorn University and IBB/TMDU on Biomedical Materials and Engineering 2020.12.22 online (Thailand)
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Hirokazu Tamamura. Bioimaging of GPCR dimers and its application to molecular probes for cancer cells. A3 Foresight & 5 Star Alliance Joint Workshop on Organic/Inorganic Hybrid Nano Materials and Bio Imaging 2020.12.03 online
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Kaho Matsumoto, Takeo Kuwata, Zahid Hasan, Yu Kaku, Shashwata Biswas, Shokichi Takahama, Hirokazu Tamamura and Shuzo Matsushita. The CD4 mimetic compound YIR-821-mediated enhancement of the neutralization activities of plasma IgG against autologous isolates in vitro.. 21st Kumamoto AIDS Seminar 2020.11.11 online(Kumamoto)
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Kofi Baffour-Awuah Owusu, Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Moemi Kaneko, Tsutomu Murakami, Hirokazu Tamamura. Exploratory studies on the development of anti-HIV-1 peptides based on HIV-1 capsid fragments. The 57th Japanese Peptide Symposium 2020.11.10 online(Tottori)