Personnel Information

写真a

MORITA Keiichi


Job title

Associate Professor

Birth date

1972

Laboratory Address

Maxillofacial Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-5499

Laboratory Fax number

+81-3-5803-0298

Mail Address

keiichi.m.osur@tmd.ac.jp

Research Areas, Keywords

oral & maxillofacial surgery, cleft lip, cleft palate, oral cancer, genome

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, 1997.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Doctor's Course, 2001.03, Completed

Degree 【 display / non-display

  • DDS, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2004.11
    -
    2010.03
    Tokyo Medical and Dental University, (Old Organization)Dental Hospital, Hospital Departments, Clinics for Oral and Maxillofacial Rehabilitation, Oral Surgery, Assistant Professor
  • 2010.04
    -
    2015.03
    Tokyo Medical and Dental University, Hard Tissue Genome Research Center, Project Junior Associate Professor
  • 2015.04
    -
    2016.03
    Tokyo Medical and Dental University, (Old Organization)Dental Hospital, Hospital Departments, Clinics for Oral and Maxillofacial Rehabilitation, Oral Surgery, Assistant Professor
  • 2016.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Surgery, Assistant Professor
  • 2018.04
    -
    2018.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Surgery, Assistant Professor
  • 2018.10
    -
    2020.08
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Surgery, Junior Associate Professor
  • 2020.09
    -
    2021.10
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Surgery, Junior Associate Professor
  • 2021.11
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Maxillofacial Surgery, Associate Professor

▼display all

Academic Society Affiliations 【 display / non-display

  • Japanese Society of Oral and Maxillofacial Surgeons

Research Areas 【 display / non-display

  • Surgical dentistry

  • Medical biochemistry

Qualification Acquired 【 display / non-display

  • Dentist

 

Research Theme 【 display / non-display

  • oral cancer

Published Papers & Misc 【 display / non-display

  1. Noboru Maruta,Kei-ichi Morita,Yosuke Harazono,Eri Anzai,Yu Akaike,Kotaro Yamazaki,Erina Tonouchi,Tetsuya Yoda. Automatic machine learning-based classification of mandibular third molar impaction status Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023.07; 35 (4): 327-334.

  2. Akaike Y, Morita KI, Sakamoto K, Tsushima F, Kayamori K, Maruta N, Yamazaki K, Anzai E, Tonouchi E, Harada H, Ikeda T, Yoda T. Automatic detection of spongiosis associated with oral lichenoid lesions using machine learning Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023.01; 35 (4): 368-374. ( DOI )

  3. Namiaki Takahara, Nobuyoshi Tomomatsu, Atsushi Kimura, Machiko Kosugi, Yasuhiro Kurasawa, Kei-Ichi Morita, Tetsuya Yoda. Changes in the condylar volume and skeletal relapse following orthognathic surgery in patients with dentofacial deformity: A retrospective study. Cranio. 2022.05; 1-11. ( PubMed, DOI )

  4. Takahara N, Tomomatsu N, Hsieh D, Kurasawa Y, Morita KI, Yoda T. Short-Term Stability After Segmental Le Fort I Maxillary Impaction Surgery With Mandibular Autorotation in Seven High-Angle Class II Patients: A Case Series. J Craniofac Surg.. 2022.03; 33 (2): e135-e138. ( PubMed, DOI )

  5. Harazono Y, Morita KI, Tonouchi E, Anzai E, Takahara N, Kohmoto T, Imoto I, Yoda T. TP63 mutation mapping information in TP63 mutation-associated syndromes Advances in Oral and Maxillofacial Surgery. 2022.01; 5 ( DOI )

  6. ティーラウォン・チャンヤーヌット , 坂本 啓, 布川 裕規, 土谷 麻衣子, 栢森 高, 明石 巧, 濱垣 美和子, 富岡 博文, 黒嶋 雄志, 森田 圭一, 原田 浩之, 池田 通. 舌癌症例にみられるヒトパピローマウイルス(HPV)感染と無関係なp16免疫染色陽性反応 口腔病学会雑誌. 2021.11; 88 (2-3): 115-126. ( ichushi )

  7. Shibata E, Morita KI, Kayamori K, Tange S, Shibata H, Harazono Y, Michi Y, Ikeda T, Harada H, Imoto I, Yoda T. Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY. 2021.10; 132 (4): 426-433. ( DOI )

  8. Kaida Atsushi, Yamamoto Satomi, Parrales Alejandro, Young Eric D., Ranjan Atul, Alalem Mohamed A., Morita Kei-ichi, Oikawa Yu, Harada Hiroyuki, Ikeda Tohru, Thomas Sufi M., Diaz Francisco J., Iwakuma Tomoo. DNAJA1 promotes cancer metastasis through interaction with mutant p53 ONCOGENE. 2021.06; ( DOI )

  9. Kawasaki R, Sasaki Y, Nishimura T, Katagiri K, Morita KI, Sekine Y, Sawada S, Mukai S, Akiyoshi K. Magnetically Navigated Protein Transduction In Vivo using Iron Oxide-Nanogel Chaperone Hybrid ADVANCED HEALTHCARE MATERIALS. 2021.05; 10 (9): ( DOI )

  10. Shibata E, Morita KI, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, Yoda T. Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst. Int J Clin Exp Pathol. 2020.08; 13 (8): 2211-2217. ( PubMed )

  11. Yahara H, Horita S, Yanamoto S, Kitagawa Y, Asaka T, Yoda T, Morita K, Michi Y, Takechi M, Shimasue H, Maruoka Y, Kondo E, Kusukawa J, Tsujiguchi H, Sato T, Kannon T, Nakamura H, Tajima A, Hosomichi K, Yahara K. A Targeted Genetic Association Study of the Rare Type of Osteomyelitis. J Dent Res.. 2020.03; 99 (3): 271-276. ( DOI )

  12. Yokokawa M, Morita KI, Oikawa Y, Kayamori K, Sakamoto K, Ikeda T, Harada H. Co-expression of EGFR and MET has a synergistic effect on the prognosis of patients with oral squamous cell carcinoma J Oral Pathol Med. 2020.03; 49 (3): 235-242. ( DOI )

  13. Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K. AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression PLOS ONE. 2020.02; 15 (2): e0222689. ( DOI )

  14. Sawangarun W, Mandasari M, Aida J, Morita K, Kayamori K, Ikeda T, Sakamoto K. Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis Experimental Cell Research. 2018.11; 372 (2): 129-140. ( DOI )

  15. Kanai Y, Nishihara H, Miyagi Y, Tsuruyama T, Taguchi K, Katoh H, Takeuchi T, Gotoh M, Kuramoto J, Arai E, Ojima H, Shibuya A, Yoshida T, Akahane T, Kasajima R, Morita K, Inazawa J, Sasaki T, Fukayama M, Oda Y. The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses Pathology International. 2018.02; 68 (2): 63-90. ( DOI )

  16. Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K. Genetic basis of calcifying cystic odontogenic tumors. PLoS One. 2017.06; 12 (6): e0180224.

  17. Nguyen CT, Okamura T, Morita KI, Yamaguchi S, Harada H, Miki Y, Izumo T, Kayamori K, Yamaguchi A, Sakamoto K. LAMC2 is a predictive marker for the malignant progression of leukoplakia. Journal of Oral Pathology & Medicine. 2017.03; 46 (3): 223-231.

  18. Oikawa Y, Morita KI, Kayamori K, Tanimoto K, Sakamoto K, Katoh H, Ishikawa S, Inazawa J, Harada H. Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma. Cancer Science. 2017.02; 108 (2): 256-266.

  19. Kato Y, Ogasawara S, Oki H, Honma R, Takagi M, Fujii Y, Nakamura T, Saidoh N, Kanno H, Umetsu M, Kamata S, Kubo H, Yamada M, Sawa Y, Morita K, Harada H, Suzuki H, Kaneko MK. Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin. Monoclon Antib Immunodiagn Immunother. . 2016; 35 (2): 109-116.

  20. Kohmoto T, Tsuji A, Morita K, Naruto T, Masuda K, Kashimada K, Enomoto K, Morio T, Harada H, Imoto I. A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome. Hum Genome Var.. 2016; 7 (3): 16003.

  21. Sato M, Morita K, Kabasawa Y, Harada H. Bilateral nasolabial cysts: a case report. J Med Case Rep.. 2016; 10 (1): 246.

  22. Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J Oral Pathol Med.. 2016; 45 (10): 730-739.

  23. Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS One. . 2016; 11 (8): e0161163.

  24. Kuribayashi Y, Tsushima F, Morita K, Matsumoto K, Sakurai J, Uesugi A, Sato K, Oda S, Sakamoto K, Harada H. Long-term outcome of non-surgical treatment in patients with oral leukoplakia. Oral Oncology. 2015.11; 51 (11): 1020-1025.

  25. Morita K, Naruto T, Tanimoto K, Yasukawa C, Oikawa Y, Masuda K, Imoto I, Inazawa J, Omura K, Harada H. Simultaneous detection of both single nucleotide variations and copy number alterations by next-generation sequencing in gorlin syndrome. PLoS One. 2015.11; 10 (11): e0140480.

  26. Sakamoto Kei, Morita Kei-Ichi, Shimada Yasuyuki, Omura Ken, Izumo Toshiyuki, Yamaguchi Akira. Peripheral odontogenic keratocyst associated with nevoid basal cell carcinoma syndrome: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014.07; 118 (1): e19-e23. ( PubMed, DOI )

  27. Matsukawa Sho, Morita Kei-ichi, Negishi Ayako, Harada Hiroyuki, Nakajima Yusuke, Shimamoto Hiroaki, Tomioka Hirofumi, Tanaka Kae, Ono Masaya, Yamada Tesshi, Omura Ken. Galectin-7 as a potential predictive marker of chemo- and/or radio-therapy resistance in oral squamous cell carcinoma. Cancer Med. 2014.04; 3 (2): 349-361. ( PubMed, DOI )

  28. Matsumoto Kanako, Morita Kei-Ichi, Jinno Shigeharu, Omura Ken. Sensory changes after tongue reduction for macroglossia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014.01; 117 (1): e1-e2. ( PubMed, DOI )

  29. Rushatamukayanunt Pradit, Morita Kei-ichi, Matsukawa Sho, Harada Hiroyuki, Shimamoto Hiroaki, Tomioka Hirofumi, Omura Ken. Lack of association between high-risk human papillomaviruses and oral squamous cell carcinoma in young Japanese patients. Asian Pac J Cancer Prev. 2014; 15 (10): 4135-4141. ( PubMed )

  30. Shimada Yasuyuki, Morita Kei-ichi, Kabasawa Yuji, Taguchi Takahide, Omura Ken. Clinical manifestations and treatment for keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome: a study in 25 Japanese patients. J Oral Pathol Med. 2013.03; 42 (3): 275-280. ( PubMed, DOI )

  31. Shimada Yasuyuki, Katsube Ken-ichi, Kabasawa Yuji, Morita Kei-ichi, Omura Ken, Yamaguchi Akira, Sakamoto Kei. Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features. PLoS One. 2013; 8 (8): e70995. ( PubMed, DOI )

  32. Kuribayashi Yuri, Tsushima Fumihiko, Sato Masaru, Morita Kei-ichi, Omura Ken. Recurrence patterns of oral leukoplakia after curative surgical resection: important factors that predict the risk of recurrence and malignancy. J Oral Pathol Med. 2012.10; 41 (9): 682-688. ( PubMed, DOI )

  33. Kugimoto T, Morita K, Omura K. Development of oral cancer screening test by detection of squamous cell carcinoma among exfoliated oral mucosal cells. Oral Oncol. 2012.09; 48 (9): 794-798. ( PubMed, DOI )

  34. Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K, Omura K, Miki Y, Yamaguchi A. Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol. 2012.07; 27 (7): 949-959. ( PubMed )

  35. Hanabata Y, Nakajima Y, Morita K, Kayamori K, Omura K. Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma. Odontology. 2012.07; 100 (2): 156-163. ( PubMed, DOI )

  36. Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012.05; 92 (5): 688-702. ( PubMed, DOI )

  37. Uesugi A, Kozaki K, Tsuruta T, Furuta M, Morita K, Imoto I, Omura K, Inazawa J. The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res. 2011.09; 71 (17): 5765-5778. ( PubMed, DOI )

  38. Marukawa E, Oshina H, Iino G, Morita K, Omura K. Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft. J Craniomaxillofac Surg. 2011.06; 39 (4): 278-283. ( PubMed, DOI )

  39. Sakamoto K, Aragaki T, Morita K, Kawachi H, Kayamori K, Nakanishi S, Omura K, Miki Y, Okada N, Katsube K, Takizawa T, Yamaguchi A. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Histopathology. 2011.03; 58 (4): 531-542. ( PubMed, DOI )

  40. Uekusa M, Omura K, Nakajima Y, Hasegawa S, Harada H, Morita KI, Tsuda H. Uptake and kinetics of 5-aminolevulinic acid in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2010.08; 39 (8): 802-805. ( PubMed, DOI )

  41. Prapinjumrune C, Morita K, Kuribayashi Y, Hanabata Y, Shi Q, Nakajima Y, Inazawa J, Omura K. DNA amplification and expression of FADD in oral squamous cell carcinoma. J Oral Pathol Med. 2010.08; 39 (7): 525-532. ( PubMed, DOI )

  42. Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol. 2010.02; 176 (2): 968-980. ( PubMed, DOI )

  43. Kuribayashi Y, Morita K, Tomioka H, Uekusa M, Ito D, Omura K. Gene expression analysis by oligonucleotide microarray in oral leukoplakia. J Oral Pathol Med. 2009.04; 38 (4): 356-361. ( PubMed, DOI )

  44. Morita K, Iwasa T, Imaizumi F, Negishi A, Omura K. A case of maxillary duplication with a soft palate reconstruction using a forearm flap. Int J Oral Maxillofac Surg. 2008.09; 37 (9): 862-865. ( PubMed, DOI )

  45. Tomioka H, Morita K, Hasegawa S, Omura K. Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. J Oral Pathol Med. 2006.04; 35 (4): 206-211. ( PubMed, DOI )

  46. Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J. 2001.11; 20 (21): 6028-6036. ( PubMed, DOI )

  47. Sawada Y, Nakamura K, Doi K, Takeda K, Tobiume K, Saitoh M, Morita K, Komuro I, De Vos K, Sheetz M, Ichijo H. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci. 2001.03; 114 (Pt 6): 1221-1227. ( PubMed )

  48. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001.03; 2 (3): 222-228. ( PubMed, DOI )

▼display all

Conference Activities & Talks 【 display / non-display

  1. T Tsujikawa, K Ohno, S Saburi, J Mitsuda, K Yoshimura, A Kimura, H Morimoto, G Ohmura, A Arai, H Ogi, S Shibata, Y Ariizumi, A Tasaki, R Takahashi, Y Tateishi, H Kawabe, S Ikeda, K Morita, T Tsunoda, T Akashi, M Kurata, I Imoto, Y Shimizu, A Watanabe, Y Asada, R Hayashi, Y Saito, H Ozawa, K Tsukahara, N Oridate, A Horii, T Maruo, N Hanai, H Inohara, H Iwai, T Fujii, K Nibu , S Iwae, T Ueda, R Yasumatsu, H Umeno, M Masuda, K Itoh, S Hirano, T Asakage. Tumor immune characterization identifies age-stratified biomarkers for nivolumab in patients with head and neck squamous cell carcinoma: A nationwide collaborative study in Japan.. American Association for Cancer Research (AACR) Annual Meeting 2022; 2022 Apr 8-13. 2022.04.08 Philadelphia (PA)

  2. Shibata E, Morita K, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, Yoda T. A case of mammary analogue secretory carcinoma in salivary duct of parotid gland. 13th Asian Congress on Oral and Maxillofacial Surgery (ACOMS) 2018.11.08

  3. Shibata E, Morita K, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, Yoda T. A case of mammary analogue secretory carcinoma in salivary duct of parotid gland. 13th Asian Congress on Oral and Maxillofacial Surgery (ACOMS) 2018.11.08

  4. Morita K, Naruto T, Tanimoto K, Yasukawa C, Oikawa Y, Masuda K, Imoto I, Inazawa J, Omura K, Harada H. Simultaneous detection of both single nucleotide variations and copy number alterations by next-generation sequencing in gorlin syndrome. . The 13th International Congress of Human Genetics 2016.04.03 Kyoto

  5. Takada J, Ogawa T, Sato C, Uezono M, Morita K, Moriyama K. A case of Holoprosencephaly with unilateral cleft lip and palate treated with maxillary distraction osteogenesis in adolescence.. The 8th International Orthodontic Congress. 2015/9/27-30 2015.09.27 London, UK.

  6. Morita K, Oikawa Y, Kayamori K, Sakamoto K, Ishikawa S, Inazawa J, Harada H. Targeted resequencing of cancer-related genes in oral cancer.. The 34th Sapporo International Cancer Symposium, 2015/6/25-27 2015.06.25 Sapporo, Japan.

  7. Keiichi Morita. Symposium II: DO & Deformity - Distraction osteogenesis for patients with cleft lip and palate at Tokyo Medical and Dental University.. The 56th Congress of the Korean Association of Oral and Maxillofacial Surgeons. April 23-25, 2015 2015.04.23 Goyang, Korea.

▼display all

 

Performance of duties 【 display / non-display

  • Bioresource Research Center,2014.11 - Now