Personnel Information

写真a

OKAZAWA Hitoshi


Job title

Professor

Laboratory Phone number

+81-3-5803-5847

Mail Address

okazawa.npat@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/npat/index.html

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Medicine, School of Medicine, 1984, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medicine, Doctor's Course, 1991, Completed

Degree 【 display / non-display

  • MD, PhD, The University of Tokyo

Campus Career 【 display / non-display

  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Neuropathology, Professor
  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neuropathology, Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Center for Brain Integration Research, Director

Academic Activity 【 display / non-display

  • The Japan Neuroscience Society Program commissioner,2005,2007
  • The Japan Neuroscience Society Council
  • The Japan Society for Neurochemistry Council
  • Japan Society for Dementia Research Council
  • The Molecular Biology Society of Japan committee

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Research Areas 【 display / non-display

  • Neurology

  • Pathological medical chemistry

  • Molecular biology

  • Nerve anatomy/Neuropathology

  • Neurophysiology / General neuroscience

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Research Theme 【 display / non-display

  • neurodegeneration,developmental disorder,stem cell, 2009 - 2015

  • neurodegeneration,developmental disorder,stem cell

Published Papers & Misc 【 display / non-display

  • Yang SS, Ishida T, Fujita K, Nakai Y, Ono T, Okazawa H. PQBP1, an intellectual disability causative gene, affects bone development and growth. Biochem Biophys Res Commun. 2020.03; 523 (4): 894-899. ( PubMed, DOI )

  • Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun . 2020.01; 11 (1): 507. ( PubMed, DOI )

  • Rahmn SK, Okazawa H, Chen YW. Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers. Journal of Structural Biology. 2019.06; 206 (3): 305-313. ( PubMed, DOI )

  • Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid beta oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 2019.02; 9 (1): 2827. ( PubMed, DOI )

  • Chen X, Kondo K, Okazawa H. Methods to image macroautophagy in the brain in vivo. Methods in Molecular Biology. 2019.01; 1880 529-534. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hitoshi Okazawa. Deciphering and tacking the ultra-early phase pathology of Alzheimer’s disease. 15th International Conference on Alzheimer’s and Parkinson’s Diseases: Mechanisms, Clinical Strategies and promising Treatments of Neurodegenerative Diseases 2021.03.09 (Spain Barcelona)

  • Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease. 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02 Okayama Convention Center(Okayama)

  • Hitoshi Okazawa. Discovery of new pathologies and development of new therapeutics based on molecular network analysis against Alzheimer's disease. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

  • Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Jin Xiaocen, Kazuhiko Tagawa, Hitoshi Okazawa. YAP-dependent necrosis regulates early stages of Alzheimer’s disease pathology. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

  • Hitoshi Okazawa. Development of gene therapies of neurodegenerative diseases targeting new pathological mechanisms. AMED -Gene & Cell Therapy Symposium 2020.02.22 Nihonbashi Life Science Building(Tokyo)

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Patents 【 display / non-display

  • ANTIBODIES AGAINST HMGB1, AND COMPOSITION COMPRISING SAME FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE

    Patent Number: 10730937

  • A prevention or a drug to cure by spinocerebellar degeneration

    Patent Number: 2013-214155

Awards & Honors 【 display / non-display

  • Narabayashi Award,Japanese Society of Neurology,2011.05