Personnel Information

写真a

OKAZAWA Hitoshi


Job title

Professor

Laboratory Phone number

+81-3-5803-5847

Mail Address

okazawa.npat@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/npat/index.html

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Medicine, School of Medicine, 1984, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medicine, Doctor's Course, 1991, Completed

Degree 【 display / non-display

  • MD, PhD, The University of Tokyo

Campus Career 【 display / non-display

  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Neuropathology, Professor
  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neuropathology, Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Center for Brain Integration Research, Director

Academic Activity 【 display / non-display

  • The Japan Neuroscience Society Program commissioner,2005,2007
  • The Japan Neuroscience Society Council
  • The Japan Society for Neurochemistry Council
  • Japan Society for Dementia Research Council
  • The Molecular Biology Society of Japan committee

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Research Areas 【 display / non-display

  • Neurology

  • Pathological medical chemistry

  • Molecular biology

  • Nerve anatomy/Neuropathology

  • Neurophysiology / General neuroscience

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Research Theme 【 display / non-display

  • neurodegeneration,developmental disorder,stem cell, 2009 - 2015

  • neurodegeneration,developmental disorder,stem cell

Published Papers & Misc 【 display / non-display

  • Hitoshi Okazawa. Intracellular amyloid hypothesis for ultra-early phase pathology of Alzheimer's disease. Neuropathology. 2021.04; 41 (2): 93-98. ( PubMed, DOI )

  • Saito M, Nakayama M, Fujita K, Uchida A, Yano H, Goto S, Okazawa H, Sone M. Role of the Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis. Genes Genet Syst. 2021.03; 95 (6): 303-314. ( PubMed, DOI )

  • Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M,...Okazawa H,et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.02; 17 (1): 1-382. ( PubMed, DOI )

  • Yang SS, Ishida T, Fujita K, Nakai Y, Ono T, Okazawa H. PQBP1, an intellectual disability causative gene, affects bone development and growth. Biochem Biophys Res Commun. 2020.03; 523 (4): 894-899. ( PubMed, DOI )

  • Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun . 2020.01; 11 (1): 507. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hitoshi Okazawa. Big data-driven research of neurodegenerative diseases. 62nd Annual Meeting of the Japanese Society of Neurology 2021.05.20 ICCKyoto(Kyoto)

  • Hitoshi Okazawa. Deciphering and tacking the ultra-early phase pathology of Alzheimer’s disease. The 15th International Conference on Alzheimer’s and Parkinson’s Diseases (online) 2021.03.11

  • Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease. 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02 Okayama Convention Center(Okayama)

  • Hitoshi Okazawa. Discovery of new pathologies and development of new therapeutics based on molecular network analysis against Alzheimer's disease. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

  • Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Jin Xiaocen, Kazuhiko Tagawa, Hitoshi Okazawa. YAP-dependent necrosis regulates early stages of Alzheimer’s disease pathology. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

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Patents 【 display / non-display

  • ANTIBODIES AGAINST HMGB1, AND COMPOSITION COMPRISING SAME FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE

    Patent Number: 10730937

  • A prevention or a drug to cure by spinocerebellar degeneration

    Patent Number: 2013-214155

Awards & Honors 【 display / non-display

  • Narabayashi Award,Japanese Society of Neurology,2011.05