基本情報

写真a

澁谷 浩司(シブヤ ヒロシ)

SHIBUYA Hiroshi


職名

教授

メールアドレス

shibuya.mcb@mri.tmd.ac.jp

ホームページ

http://www.tmd.ac.jp/mri/mri-mcb/index_j.html

分野紹介URL

https://www.tmd.ac.jp/mcb/

出身学校 【 表示 / 非表示

  • 筑波大学  第二学群  農林学類  1983年03月  卒業

出身大学院 【 表示 / 非表示

  • 筑波大学  環境科学研究科  修士課程  1985年03月  修了

  • 大阪大学  理学研究科  博士課程  1990年03月  修了

取得学位 【 表示 / 非表示

  • 博士(理学)  

経歴(学内) 【 表示 / 非表示

  • 2000年09月
    -
    2022年04月
    東京医科歯科大学 難治疾患研究所 先端分子医学研究部門 分子細胞生物学 教授
  • 2014年04月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 生命理工学系専攻 生命理工学講座 分子細胞生物学 教授
  • 2017年04月
    -
    2018年03月
    東京医科歯科大学 役職員 副理事
  • 2018年04月
    -
    2020年03月
    東京医科歯科大学 役職員 副学長
  • 2019年04月
    -
    現在
    東京医科歯科大学 役職員 発生学領域領域長
  • 2020年04月
    -
    現在
    東京医科歯科大学 役職員 学長特別補佐
  • 2021年04月
    -
    現在
    東京医科歯科大学 役職員 広報部副部長
  • 2022年05月
    -
    現在
    東京医科歯科大学 難治疾患研究所 未来生命科学研究部門 分子細胞生物学分野 教授

▼全件表示

経歴(学外) 【 表示 / 非表示

  • 1985年04月
    -
    1994年07月
    日本ベーリンガーインゲルハイム株式会社 川西医薬研究所分子生物学研究部 研究員
  • 1994年08月
    -
    1997年06月
    北海道大学 薬学部 助教授
  • 1997年07月
    -
    2000年08月
    岡崎国立共同研究機構 基礎生物学研究所  助教授

所属学協会 【 表示 / 非表示

  • 日本分子生物学会

委員歴 【 表示 / 非表示

  • 2017年04月
    -
    2018年11月
    日本分子生物学会 第41回日本分子生物学会年会組織委員長
 

競争的資金等の研究課題 【 表示 / 非表示

  • WNK-Wntシグナルによる神経分化制御機構の解明

    文部科学省/日本学術振興会 : 2018年 - 2020年

  • WNKシグナルによる発生制御機構の解明

    文部科学省/日本学術振興会 : 2011年 - 2013年

  • WNKによるWntシグナル制御と神経分化制御機構の解明

    文部科学省/日本学術振興会

論文・総説 【 表示 / 非表示

  1. Shimizu M, Shibuya H. WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway. Scientific reports. 2022.09; 12 (1): 15858. ( PubMed, DOI )

  2. Shimizu M, Shibuya H, Tanaka N. Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells. Scientific reports. 2022.02; 12 (1): 2910. ( PubMed, DOI )

  3. Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi. WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): 666. ( PubMed, DOI )

  4. Nishita M., Nishikaku I., Yoshida E., Kamizaki K., Shibuya H., Matsumoto K., Minami Y.. Roil promotes invasion of lung adenocarcinoma cells through small GTPase Rif-mediated filopodia formation MOLECULAR BIOLOGY OF THE CELL. 2018.12; 29 (26): 231.

  5. Sato A, Shibuya H.. Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. PLoS One. 2018.03; 13 e0193204.

  6. Toshiyasu Goto, Junhei Matsuzawa, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett.. 2016.05; 590 (9): 1291-1303. ( PubMed, DOI )

  7. Takashi Fukuzono, Strahil Iv Pastuhov, Okinobu Fukushima, Chun Li, Ayuna Hattori, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya, Hiroshi Hanafusa, Kunihiro Matsumoto, Naoki Hisamoto. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Genes Cells. 2016.04; 21 (4): 311-324. ( PubMed, DOI )

  8. Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016; 7 11391. ( PubMed, DOI )

  9. Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya, Tohru Ishitani. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014.09; 8 (5): 1391-1404. ( PubMed, DOI )

  10. Toshiyasu Goto, Atsushi Sato, Shungo Adachi, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya. IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J. Biol. Chem.. 2013.12; 288 (51): 36351-36360. ( PubMed, DOI )

  11. Masahiro Shimizu, Toshiyasu Goto, Atsushi Sato, Hiroshi Shibuya. WNK4 is an essential effector of anterior formation in FGF signaling. Genes Cells. 2013.06; 18 (6): 442-449. ( PubMed, DOI )

  12. Atsushi Sato, Hiroshi Shibuya. WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013; 8 (1): e55301. ( PubMed, DOI )

  13. Toshiyasu Goto, Atsushi Sato, Masahiro Shimizu, Shungo Adachi, Kiyotoshi Satoh, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya. IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS ONE. 2013; 8 (4): e60865. ( PubMed, DOI )

  14. Hiroshi Hanafusa, Kouki Ishikawa, Shin Kedashiro, Tsukasa Saigo, Shun-Ichiro Iemura, Tohru Natsume, Masayuki Komada, Hiroshi Shibuya, Atsuki Nara, Kunihiro Matsumoto. Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun. 2011.01; 2 158. ( PubMed, DOI )

  15. Toshiyasu Goto, Akimasa Fukui, Hiroshi Shibuya, Ray Keller, Makoto Asashima. Xenopus furry contributes to release of microRNA gene silencing. Proc. Natl. Acad. Sci. U.S.A.. 2010.11; 107 (45): 19344-19349. ( PubMed, DOI )

  16. Takeshi Maruyama, Hisae Kadowaki, Noriaki Okamoto, Atsushi Nagai, Isao Naguro, Atsushi Matsuzawa, Hiroshi Shibuya, Keiji Tanaka, Shigeo Murata, Kohsuke Takeda, Hideki Nishitoh, Hidenori Ichijo. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J.. 2010.08; 29 (15): 2501-2514. ( PubMed, DOI )

  17. Akira Nifuji, Hisashi Ideno, Yoshio Ohyama, Rieko Takanabe, Ryoko Araki, Masumi Abe, Masaki Noda, Hiroshi Shibuya. Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp. Cell Res.. 2010.04; 316 (7): 1127-1136. ( PubMed, DOI )

  18. Eriko Ohnishi, Toshiyasu Goto, Atsushi Sato, Mi-Sun Kim, Shun-Ichiro Iemura, Tohru Ishitani, Tohru Natsume, Junji Ohnishi, Hiroshi Shibuya. Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. Mol. Cell. Biol.. 2010.02; 30 (3): 675-683. ( PubMed, DOI )

  19. Yukihide Watanabe, Susumu Itoh, Toshiyasu Goto, Eriko Ohnishi, Masako Inamitsu, Fumiko Itoh, Kiyotoshi Satoh, Eliza Wiercinska, Weiwen Yang, Liang Shi, Aya Tanaka, Naoko Nakano, A Mieke Mommaas, Hiroshi Shibuya, Peter Ten Dijke, Mitsuyasu Kato. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell. 2010.01; 37 (1): 123-134. ( PubMed, DOI )

  20. Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto, Eriko Ohnishi, Toshiyuki Hiramatsu, Isao Kii, Miyo Yoshida, Teikichi Ikura, Hiroshi Onogi, Hiroshi Shibuya, Takamitsu Hosoya, Nobutoshi Ito, Masatoshi Hagiwara. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010; 1 86. ( PubMed, DOI )

  21. Hisamoto N, Moriguchi T, Urushiyama S, Mitani S, Shibuya H, Matsumoto K. Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep. 2008.01; 9 (1): 70-75. ( PubMed, DOI )

  22. Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H. Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. Mol Cell Biol. 2007.11; 27 (21): 7623-7630. ( PubMed, DOI )

  23. Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metabolism. 2007.05; 5 (5): 331-344. ( PubMed, DOI )

  24. Matsubara Y, Kawasaki I, Urushiyama S, Yasuda T, Shirakata M, Iino Y, Shibuya H, Yamanashi Y. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells. 2007.03; 12 (3): 407-420. ( PubMed, DOI )

  25. Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). J Biol Chem. 2006.07; 281 (30): 20749-20760. ( PubMed, DOI )

  26. Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells. 2006.02; 11 (2): 143-151. ( PubMed, DOI )

  27. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005.12; 280 (52): 42685-42693. ( PubMed, DOI )

  28. Ohnishi J, Ohnishi E, Shibuya H, Takahashi T. Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005.08; 1751 (1): 95-109. ( PubMed, DOI )

  29. Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 2004.12; 64 (23): 8496-8501. ( PubMed, DOI )

  30. Aoyama Y, Urushiyama S, Yamada M, Kato C, Ide H, Higuchi S, Akiyama T, Shibuya H. MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling. Genes Cells. 2004.11; 9 (11): 1093-1101. ( PubMed, DOI )

  31. Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004.06; 279 (23): 24246-24254. ( PubMed, DOI )

  32. Ohkawara B, Shirakabe K, Hyodo-Miura J, Matsuo R, Ueno N, Matsumoto K, Shibuya H. Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 2004.02; 18 (4): 381-386. ( PubMed, DOI )

  33. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003.12; 22 (23): 6277-6288. ( PubMed, DOI )

  34. Yamada M, Ohkawara B, Ichimura N, Hyodo-Miura J, Urushiyama S, Shirakabe K, Shibuya H. Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein. Genes Cells. 2003.08; 8 (8): 677-684. ( PubMed )

  35. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003.07; 8 (7): 645-654. ( PubMed )

  36. Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S. Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol. 2003.03; 5 (3): 224-230. ( PubMed, DOI )

  37. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003.01; 23 (1): 131-139. ( PubMed )

  38. Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002.12; 119 (2): 239-249. ( PubMed )

  39. Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H. Involvement of NLK and Sox11 in neural induction in Xenopus development. Genes Cells. 2002.05; 7 (5): 487-496. ( PubMed )

  40. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T. Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001.12; 6 (12): 1091-1099. ( PubMed )

  41. Shirakabe K, Terasawa K, Miyama K, Shibuya H, Nishida E. Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5. Genes Cells. 2001.10; 6 (10): 851-856. ( PubMed )

  42. Sugawara K, Morita K, Ueno N, Shibuya H. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Genes Cells. 2001.07; 6 (7): 599-606. ( PubMed )

  43. Morita K, Shimizu M, Shibuya H, Ueno N. A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Proc Natl Acad Sci U S A. 2001.05; 98 (11): 6284-6288. ( PubMed, DOI )

  44. Ohnishi J, Ohnishi E, Jin M, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahashi T. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Mol Endocrinol. 2001.05; 15 (5): 747-764. ( PubMed )

  45. Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K. Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001.02; 276 (7): 5331-5338. ( PubMed, DOI )

  46. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000.07; 14 (14): 1741-1749. ( PubMed )

  47. Hanafusa H, Masuyama N, Kusakabe M, Shibuya H, Nishida E. The TGF-beta family member derriere is involved in regulation of the establishment of left-right asymmetry. EMBO Rep. 2000.07; 1 (1): 32-39. ( PubMed, DOI )

  48. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 2000.06; 275 (23): 17647-17652. ( PubMed, DOI )

  49. Takatsu Y, Nakamura M, Stapleton M, Danos MC, Matsumoto K, O'Connor MB, Shibuya H, Ueno N. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol. 2000.05; 20 (9): 3015-3026. ( PubMed )

  50. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000.04; 5 (4): 649-658. ( PubMed )

  51. Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW. Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 2000.02; 403 (6771): 781-785. ( PubMed, DOI )

  52. Nishita M, Ueno N, Shibuya H. Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling. Genes Cells. 1999.10; 4 (10): 583-591. ( PubMed )

  53. Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem. 1999.09; 274 (38): 27161-27167. ( PubMed )

  54. Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 1999.06; 399 (6738): 798-802. ( PubMed, DOI )

  55. Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E. Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. J Biol Chem. 1999.04; 274 (17): 12163-12170. ( PubMed )

  56. Miyama K, Yamada G, Yamamoto TS, Takagi C, Miyado K, Sakai M, Ueno N, Shibuya H. A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. Dev Biol. 1999.04; 208 (1): 123-133. ( PubMed, DOI )

  57. Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science. 1999.03; 283 (5408): 1739-1742. ( PubMed )

  58. Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999.01; 18 (1): 179-187. ( PubMed, DOI )

  59. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H. BRAM1, a BMP receptor-associated molecule involved in BMP signalling. Genes Cells. 1998.04; 3 (4): 257-264. ( PubMed )

  60. Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K, Nishida E, Ueno N. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 1998.02; 17 (4): 1019-1028. ( PubMed, DOI )

  61. Akiyama S, Katagiri T, Namiki M, Yamaji N, Yamamoto N, Miyama K, Shibuya H, Ueno N, Wozney JM, Suda T. Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. Exp Cell Res. 1997.09; 235 (2): 362-369. ( PubMed, DOI )

  62. Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem. 1997.03; 272 (13): 8141-8144. ( PubMed )

  63. Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 1996.06; 271 (23): 13675-13679. ( PubMed )

  64. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996.05; 272 (5265): 1179-1182. ( PubMed )

  65. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995.12; 270 (5244): 2008-2011. ( PubMed )

  66. Shibuya H, Kohu K, Yamada K, Barsoumian EL, Perlmutter RM, Taniguchi T. Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene. Mol Cell Biol. 1994.09; 14 (9): 5812-5819. ( PubMed )

  67. Shibuya H, Yoneyama M, Ninomiya-Tsuji J, Matsumoto K, Taniguchi T. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell. 1992.07; 70 (1): 57-67. ( PubMed )

  68. Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature. 1992.06; 357 (6380): 700-702. ( PubMed, DOI )

  69. Hatakeyama M, Kawahara A, Mori H, Shibuya H, Taniguchi T. c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain. Proc Natl Acad Sci U S A. 1992.03; 89 (6): 2022-2026. ( PubMed )

  70. Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T. The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Res. 1990.07; 18 (13): 3697-3703. ( PubMed )

  71. Shibuya H, Taniguchi T. Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene. Nucleic Acids Res. 1989.11; 17 (22): 9173-9184. ( PubMed )

  72. Shibuya H, Yoneyama M, Taniguchi T. Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol. 1989; 1 (1): 43-49. ( PubMed )

  73. Fujita T, Shibuya H, Hotta H, Yamanishi K, Taniguchi T. Interferon-beta gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer. Cell. 1987.05; 49 (3): 357-367. ( PubMed )

  74. Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M, Taniguchi T. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell. 1987.01; 48 (2): 343-350. ( PubMed )

  75. Fujita T, Shibuya H, Ohashi T, Yamanishi K, Taniguchi T. Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell. 1986.08; 46 (3): 401-405. ( PubMed )

  76. Goto Toshiyasu, Michiue Tatsuo, Shibuya Hiroshi. ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis DEVELOPMENT GROWTH & DIFFERENTIATION. 2022.05; 64 (5): 254-260. ( PubMed, DOI, 医中誌 )

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講演・口頭発表等 【 表示 / 非表示

  1. Michiru Nishita, Koki Kamizaki, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto, Yasuhiro Minami. Ror1 signaling through Dvl and Rif promotes invasion of lung adenocarcinoma cells.. ASCB(米国細胞生物学会) 2019.12

  2. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c-mediated dephosphorylation of Dishevelled sustains Wnt signal transduction. 11th International Conference on Zebrafish Development and Genetics 2014.06.27 Madison, Wisconsin, USA

  3. 後藤利保、道上達男、澁谷浩司. ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis.. 第93回日本動物学会年会 2022.09.08 東京都 早稲田

  4. 佐藤淳、澁谷浩司. GSK3b fuctions as a positive effector in WNK signaling pathway. 第41回日本分子生物学会年会 2018.11.28

  5. 佐藤淳、澁谷浩司. GSK3bはWNKシグナル伝達経路の正の制御因子として機能する. ConBio2017 2017.12.07 神戸

  6. 後藤利保、佐藤淳、足立俊吾、家村俊一郎、夏目徹、澁谷浩司. beta-cateninの分解におけるWDR26の機能解析. 第11回日本ツメガエル研究集会 2017.09.07 宮崎県えびの市

  7. 後藤利保、松澤純平、家村俊一郎、夏目徹、澁谷浩司. WDR26によるbeta-cateninの分解機構の解析. 第39回日本分子生物学会年会 2016.11.30

  8. 後藤利保、松澤純平、家村俊一郎、夏目徹、澁谷浩司. WDR26 is a new patner of Axin1 in canonical Wnt signaling Pathway.. 第38回日本分子生物学会年会 2015.12

  9. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Dephosphorylation of Dishevelled mediated by Hipk2 and PP1c sustains Wnt signal transduction. 第66回日本細胞生物学会大会 2014.06.11 奈良市

  10. Atsushi Sato, Hiroshi Shibuya. WNK signaling is involved in neural development via Lhx8/Awh.. The 11th Japanese Drosophila Research Conference 2014.06.04 金沢

  11. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c-mediated dephosphorylation of Dishevelled sustains Wnt signal transduction. 第47回日本発生生物学会年会 2014.05.27 名古屋市

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その他業績 【 表示 / 非表示

  • 「遺伝性の神経障害を引き起こすWNK1/HSN2変異体の機能解明」 ― 遺伝性感覚自律ニューロパチーⅡ型の発症機構解明に寄与 ―,2022年09月

    Scientific Reports

  • 「大腸がんに関与するWntシグナルを血圧調節分子WNKが制御する」― 大腸がんに対する新たな抗がん剤標的分子として期待 ―,2020年11月

    Communications Biology

 

担当授業科目(学内) 【 表示 / 非表示

  • 細胞生物学特論

  • 生命科学特論II

  • 細胞機能調節学特論・演習

  • 医歯学総合概論

  • 分子細胞生物学演習

社会貢献活動 【 表示 / 非表示

  • 非哺乳類を用いた基礎研究,株式会社 医学書院,週刊医学界新聞 /WEB版,2018年08月23日