基本情報

写真a

木村 彰方(キムラ アキノリ)

KIMURA Akinori


職名

特任教授

生年

1953年

研究室住所

東京都文京区湯島1−5−45

研究室電話番号

03-5803-4633

研究室FAX番号

03-5803-0100

メールアドレス

メールによる問い合わせは《こちら》から

ホームページ

http://www.tmd.ac.jp/mri/mri-mpath/index_j.html

研究分野・キーワード

心筋症, 不整脈, ゲノム医学, 人類遺伝学, 遺伝子診断, ゲノム多様性, 心筋梗塞, HIV/AIDS, 動脈硬化, 自己免疫疾患, HLA

出身学校 【 表示 / 非表示

  • 九州大学  医学部  1978年03月  卒業

出身大学院 【 表示 / 非表示

  • 九州大学  医学研究科  内科系  博士課程  1983年  修了

取得学位 【 表示 / 非表示

  • 医学博士  九州大学

経歴(学内) 【 表示 / 非表示

  • 1995年03月
    -
    2019年03月
    東京医科歯科大学 難治疾患研究所 難治病態研究部門 分子病態分野 教授
  • 2000年04月
    -
    2019年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 先端医療開発学講座 遺伝制御学 教授
  • 2008年04月
    -
    2017年03月
    東京医科歯科大学 副学長
  • 2019年04月
    -
    2020年03月
    東京医科歯科大学 特命副学長
  • 2020年04月
     
     
    東京医科歯科大学 役職員 理事
  • 2020年05月
    -
    2022年03月
    東京医科歯科大学 役職員 理事
  • 2022年04月
    -
    現在
    東京医科歯科大学 特任教授

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経歴(学外) 【 表示 / 非表示

  • 1983年4月 九州大学医学部付属遺伝情報実験施設 助手に採用
  • 1983年5月 九州大学生体防御医学研究所 助手に配置換え
  • 1983年9月 パリ・パスツール研究所 留学(1984年10月より同上休職)
  • 1986年3月 同上より帰国、復職
  • 1992年4月 九州大学生体防御医学研究所 助教授に昇任
  • 1995年3月 東京医科歯科大学難治疾患研究所 教授に昇任
  • (2003年6月~8月) パリ筋疾患研究所にて研究(文部省在外研究員)
  • 現在に至る

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所属学協会 【 表示 / 非表示

  • 日本組織適合性学会

  • 日本人類遺伝学会

  • 日本循環器学会

  • 日本移植学会

  • 国際組織適合性会議

  • 日本血管生物医学会

  • 日本内科学会

  • 日本分子生物学会

  • 日本性差医学・医療学会

  • 日仏医学会

  • 国際心臓研究学会 日本部会

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委員歴 【 表示 / 非表示

  • 日本組織適合性学会 理事、評議員
  • 日本人類遺伝学会 評議員
  • 日本循環器学会 評議員
  • 1992年09月
    -
    2019年05月
    国際組織適合性会議 評議員
  • 日本血管生物医学会 評議員
  • 2006年04月
    -
    2009年03月
    (財)日本学術振興会・学術システム研究センター 専門研究員
  • 2010年04月
    -
    2013年03月
    (独)大学入試センター・第一委員会 委員
  • 2009年04月
    -
    現在
    (財)大学基準協会 大学評価委員会 委員
  • 2015年04月
    -
    2019年05月
    (財)大学基準協会 大学評価企画立案委員会 委員
  • 2015年06月
    -
    現在
    (財)大学基準協会 基準委員会 委員
  • 2000年01月
    -
    現在
    (社)日本臓器移植ネットワーク・移植検査委員会(委員)、(財)骨髄移植推進財団・倫理委員会(委員長)、(財)骨髄移植推進財団・HLA委員会(委員)、(財)骨髄移植推進財団・データ試料等検討委員会(副委員長) 委員
  • 学術誌編集委員など:Journal of Human Genetics (Associate Editor), PLoS ONE (Academic Editor) 以下Editorial Board Member: International Journal of Immunogenetics, MHC, World Journal of Cardiology, Immunogentics

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研究分野 【 表示 / 非表示

  • 医化学

  • 免疫遺伝学

資格、免許 【 表示 / 非表示

  • 医師

 

研究テーマ 【 表示 / 非表示

  • Genome Medicine,1995年

  • 1)難治性循環器疾患(心筋症、不整脈、冠動脈硬化)の病因・病態解明、2)感染症・免疫関連疾患(AIDS、自己免疫疾患)の病因・病態解明、3)ヒトゲノム多様性の進化学的意義,1995年

競争的資金等の研究課題 【 表示 / 非表示

  • 新型コロナウイルス感染症(COVID-19)の長期合併症の実態把握と病態生理解明に向けた基盤研究

    厚生労働省 : 2020年09月 - 2021年03月

  • 心筋症の遺伝的病因に基づく新規予防、治療法の開発

    文部科学省/日本学術振興会 : 2017年 - 2019年

  • 心不全および不整脈病態形成に関わる遺伝子異常と発現異常の解明と治療戦略の開発

    文部科学省/日本学術振興会 : 2016年 - 2018年

  • NKレセプターリガンド群の機能多様性による免疫制御機構の解明

    文部科学省/日本学術振興会 : 2015年 - 2017年

  • IkBL分子機能に着目した新たな免疫・感染制御機序の解明とその応用

    文部科学省/日本学術振興会 : 2015年 - 2016年

  • 遺伝性心筋症の病因と病態形成機構の解明を基盤とした心不全治療・予防戦略の開発

    文部科学省/日本学術振興会 : 2014年 - 2016年

  • T細胞誘導を主とする予防エイズワクチン開発に関する研究

    厚生労働省 : 2013年04月 - 2016年03月

  • 心不全に関わる遺伝子異常と病態形成機構の解明に立脚した治療戦略の開発

    文部科学省/日本学術振興会 : 2013年 - 2015年

  • 遺伝子変異に起因する細胞内分子動態異常に着目した心筋機能の制御

    文部科学省/日本学術振興会 : 2013年 - 2014年

  • 自己免疫疾患の発症要因としてのNKレセプターリガンド群の発現抑制機構

    文部科学省/日本学術振興会 : 2012年 - 2014年

  • 難治性心疾患の病態発現における性差構築の分子機序

    文部科学省/日本学術振興会 : 2011年 - 2012年

  • 心筋症の分子病態解明に立脚した心不全治療戦略の開発

    文部科学省/日本学術振興会 : 2010年 - 2012年

  • 心不全に関わる遺伝子異常と病態形成機構の解明に立脚した治療戦略の開発

    文部科学省/日本学術振興会

  • 心筋症の遺伝的病因に基づく新規予防、治療法の開発

    文部科学省/日本学術振興会

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論文・総説 【 表示 / 非表示

  1. Nakashima Y, Kubo T, Sugiura K, Ochi Y, Takahashi A, Baba Y, Hirota T, Yamasaki N, Kimura A, Doi YL, Kitaoka H. Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society. 2020.08; ( PubMed, DOI )

  2. Enomoto H, Mittal N, Inomata T, Arimura T, Izumi T, Kimura A, Fukuda K, Makino S. Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. Cardiovascular research. 2020.06; ( PubMed, DOI )

  3. Ishii Hiroshi, Matsuoka Saori, Ikeda Noriko, Kurihara Kyoko, Ueno Takamasa, Takiguchi Masafumi, Naruse Taeko K., Kimura Akinori, Yokoyama Masaru, Sato Hironori, Matano Tetsuro. Determination of a T cell receptor of potent CD8(+) T cells against simian immunodeficiency virus infection in Burmese rhesus macaques BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.01; 521 (4): 894-899. ( PubMed, DOI )

  4. Higashikuse Yuta, Mittal Nishant, Arimura Takuro, Yoon Sung Han, Oda Mayumi, Enomoto Hirokazu, Kaneda Ruri, Hattori Fumiyuki, Suzuki Takeshi, Kawakami Atsushi, Gasch Alexander, Furukawa Tetsushi, Labeit Siegfried, Fukuda Keiichi, Kimura Akinori, Makino Shinji. Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients DISEASE MODELS & MECHANISMS. 2019.11; 12 (11): ( PubMed, DOI )

  5. 谷本 幸介, 成瀬 妙子, 木村 彰方. ヒト以外の動物種を対象としたNGSによるMHCタイピング法 MHC: Major Histocompatibility Complex. 2019.08; 26 (2): 115-123. ( DOI )

  6. An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A. MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages. Journal of molecular and cellular cardiology. 2019.08; 133 26-35. ( PubMed, DOI )

  7. Naruse Taeko K., Akari Hirofumi, Matano Tetsuro, Kimura Akinori. Diversity of ULBP5 in Old-World monkeys(Cercopithecidae) and divergence of the ULBP gene family in primates Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 2018.12; 94 (10): 441-453. ( 医中誌 )

  8. Inagaki Natsuko, Hayashi Takeharu, Takei Yasuyoshi, Tanimoto Kousuke, Chikamori Taishiro, Kimura Akinori. Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction Journal of Human Genetics. 2018.12; 63 (12): 1273-1276. ( 医中誌 )

  9. Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F. Genetic determinants and an epistasis of <i>LILRA3</i> and HLA-B*52 in Takayasu arteritis. Proceedings of the National Academy of Sciences of the United States of America. 2018.11; ( PubMed, DOI )

  10. Takahashi N, Matsuoka S, Thi Minh TT, Ba HP, Naruse TK, Kimura A, Shiino T, Kawana-Tachikawa A, Ishikawa K, Matano T, Nguyen Thi LA. Human leukocyte antigen-associated gag and nef polymorphisms in HIV-1 subtype A/E-infected individuals in Vietnam. Microbes and infection. 2018.10; ( PubMed, DOI )

  11. Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura. Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction. J. Hum. Genet.. 2018.09; ( PubMed, DOI )

  12. Hayashi Takeharu, Tanimoto Kousuke, Hirayama-Yamada Kayoko, Tsuda Etsuko, Ayusawa Mamoru, Nunoda Shinichi, Hosaki Akira, Kimura Akinori. Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy Journal of Human Genetics. 2018.09; 63 (9): 989-996. ( 医中誌 )

  13. Takeharu Hayashi, Kousuke Tanimoto, Kayoko Hirayama-Yamada, Etsuko Tsuda, Mamoru Ayusawa, Shinichi Nunoda, Akira Hosaki, Akinori Kimura. Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy. J. Hum. Genet.. 2018.06; ( PubMed, DOI )

  14. Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G Spoonamore, Richard J Kovacs, Matteo Vatta, Mai Iizuka, Masumi Saito, Shotaro Wani, Yuichi Hiraoka, Akinori Kimura, Hidehito Kuroyanagi. Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization. Sci Rep. 2018.06; 8 (1): 8970. ( PubMed, DOI )

  15. An Jianbo, Naruse Taeko K., Kimura Akinori. MKL1 Affects Proliferation/Survival Property of Pro-Atherogenic Macrophages ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018.05; 38 ( DOI )

  16. Tsujii Nobuyuki, Hayashi Takeharu, Hayashi Tamaki, Kimura Akinori, Nishikubo Toshiya. Barth syndrome associated with triple mutation(和訳中) Pediatrics International. 2018.04; 60 (4): 385-387. ( 医中誌 )

  17. Nobuyuki Tsujii, Takeharu Hayashi, Tamaki Hayashi, Akinori Kimura, Toshiya Nishikubo. Barth syndrome associated with triple mutation. Pediatr Int. 2018.03; ( PubMed, DOI )

  18. Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka, Yoshihisa Yamane, Takeharu Hayashi, Akinori Kimura. Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance. Am. J. Physiol. Heart Circ. Physiol.. 2018.02; ( PubMed, DOI )

  19. Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018.02; 11 (516): ( PubMed, DOI )

  20. Haruhito Harada, Takeharu Hayashi, Hirofumi Nishi, Ken Kusaba, Yoshinori Koga, Yasutoshi Koga, Ikuya Nonaka, Akinori Kimura. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy. J. Hum. Genet.. 2018.02; 63 (2): 249-254. ( PubMed, DOI )

  21. Harada Haruhito, Hayashi Takeharu, Nishi Hirofumi, Kusaba Ken, Koga Yoshinori, Koga Yasutoshi, Nonaka Ikuya, Kimura Akinori. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy Journal of Human Genetics. 2018.02; 63 (2): 249-254. ( 医中誌 )

  22. Naruse TK, Akari H, Matano T, Kimura A. Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2018; 94 (10): 441-453. ( PubMed, DOI )

  23. Watanabe T, Kimura A, Kuroyanagi H. Alternative Splicing Regulator RBM20 and Cardiomyopathy. Frontiers in molecular biosciences. 2018; 5 105. ( PubMed, DOI )

  24. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K Naruse, Mamoru Watanabe, Akinori Kimura. MKL1 expressed in macrophages contributes to the development of murine colitis. Sci Rep. 2017.10; 7 (1): 13650. ( PubMed, DOI )

  25. Sayuri Seki, Takushi Nomura, Masako Nishizawa, Hiroyuki Yamamoto, Hiroshi Ishii, Saori Matsuoka, Teiichiro Shiino, Hironori Sato, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts. PLoS Pathog.. 2017.09; 13 (9): e1006638. ( PubMed, DOI )

  26. Zhiyong Chen, Yan Wang, Masataka Kuwana, Xue Xu, Wei Hu, Xuebing Feng, Hong Wang, Akinori Kimura, Lingyun Sun. HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis. J. Rheumatol.. 2017.09; 44 (9): 1389-1393. ( PubMed, DOI )

  27. Teruki Sato, Chitose Sato, Ayumi Kadowaki, Hiroyuki Watanabe, Lena Ho, Junji Ishida, Tomokazu Yamaguchi, Akinori Kimura, Akiyoshi Fukamizu, Josef M Penninger, Bruno Reversade, Hiroshi Ito, Yumiko Imai, Keiji Kuba. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc. Res.. 2017.06; 113 (7): 760-769. ( PubMed, DOI )

  28. John M Gregson, Daniel F Freitag, Praveen Surendran, Nathan O Stitziel, Rajiv Chowdhury, Stephen Burgess, Stephen Kaptoge, Pei Gao, James R Staley, Peter Willeit, Sune F Nielsen, Muriel Caslake, Stella Trompet, Linda M Polfus, Kari Kuulasmaa, Jukka Kontto, Markus Perola, Stefan Blankenberg, Giovanni Veronesi, Francesco Gianfagna, Satu Männistö, Akinori Kimura, Honghuang Lin, Dermot F Reilly, Mathias Gorski, Vladan Mijatovic, , Patricia B Munroe, Georg B Ehret, , Alex Thompson, Maria Uria-Nickelsen, Anders Malarstig, Abbas Dehghan, , Thomas F Vogt, Taishi Sasaoka, Fumihiko Takeuchi, Norihiro Kato, Yoshiji Yamada, Frank Kee, Martina Müller-Nurasyid, Jean Ferrières, Dominique Arveiler, Philippe Amouyel, Veikko Salomaa, Eric Boerwinkle, Simon G Thompson, Ian Ford, J Wouter Jukema, Naveed Sattar, Chris J Packard, Abdulla Al Shafi Majumder, Dewan S Alam, Panos Deloukas, Heribert Schunkert, Nilesh J Samani, Sekar Kathiresan, , Børge G Nordestgaard, Danish Saleheen, Joanna Mm Howson, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, . Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles. Eur J Prev Cardiol. 2017.03; 24 (5): 492-504. ( PubMed, DOI )

  29. Inagaki Natsuko, Hayashi Takeharu, Takei Yasuyoshi, Chikamori Taishiro, Yamashina Akira, Kimura Akinori. 心室中部閉塞型肥大型心筋症の遺伝子解析(Genetic Analysis of Hypertrophic Cardiomyopathy with Mid-ventricular Obstruction Phenotype) 日本循環器学会学術集会抄録集. 2017.03; 81回 PE-429. ( 医中誌 )

  30. Paku Yooki, Watanabe Masataka, Iwasaki Youichi, Kobayashi Masatake, Inagaki Natsuko, Hirayama Kayoko, Hayashi Takeharu, Kimura Akinori, Yamashina Akira. TTNフレームシフト変異が認められた拡張型心筋症の1症例(A TTN Frameshift Mutation Found in a Patient with Dilated Cardiomyopathy) 日本循環器学会学術集会抄録集. 2017.03; 81回 SS07-6. ( 医中誌 )

  31. Eri Kikkawa, Masafumi Tanaka, Taeko K Naruse, Tomi T Tsuda, Michio Tsuda, Koichi Murata, Akinori Kimura. Diversity of MHC class I alleles in Spheniscus humboldti. Immunogenetics. 2017.02; 69 (2): 113-124. ( PubMed, DOI )

  32. Sumire Iseda, Naofumi Takahashi, Hugo Poplimont, Takushi Nomura, Sayuri Seki, Taku Nakane, Midori Nakamura, Shoi Shi, Hiroshi Ishii, Shota Furukawa, Shigeyoshi Harada, Taeko K Naruse, Akinori Kimura, Tetsuro Matano, Hiroyuki Yamamoto. Biphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization. J. Virol.. 2016.07; 90 (14): 6276-6290. ( PubMed, DOI )

  33. Hideki Kawai, Shin-Ichiro Morimoto, Yoko Takakuwa, Akihiro Ueda, Ken-Ichi Inada, Masayoshi Sarai, Takuro Arimura, Tatsuro Mutoh, Akinori Kimura, Yukio Ozaki. Hypertrophic Cardiomyopathy Accompanied by Spinocerebellar Atrophy With a Novel Mutation in Troponin I Gene. Int Heart J. 2016.07; 57 (4): 507-510. ( PubMed, DOI )

  34. Hiroshi Ishii, Saori Matsuoka, Takushi Nomura, Midori Nakamura, Teiichiro Shiino, Yuko Sato, Naoko Iwata-Yoshikawa, Hideki Hasegawa, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Yoshio Koyanagi, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model. Sci Rep. 2016.07; 6 30153. ( PubMed, DOI )

  35. Masayoshi Oikawa, Nobuo Sakamoto, Atsushi Kobayashi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yuichirou Kiko, Hajime Nakano, Takeharu Hayashi, Akinori Kimura, Yasuchika Takeishi. Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body. BMC Cardiovasc Disord. 2016.05; 16 83. ( PubMed, DOI )

  36. Taeko K Naruse, Daisuke Sakurai, Hitoshi Ohtani, Gaurav Sharma, Surendra K Sharma, Madhu Vajpayee, Narinder K Mehra, Gurvinder Kaur, Akinori Kimura. APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population. J. Hum. Genet.. 2016.03; 61 (3): 263-265. ( PubMed, DOI )

  37. Toshihiro Tanaka, Akinori Kimura. Cardiovascular genetics. J. Hum. Genet.. 2016.01; 61 (1): 1. ( PubMed, DOI )

  38. Akinori Kimura. Molecular genetics and pathogenesis of cardiomyopathy. J. Hum. Genet.. 2016.01; 61 (1): 41-50. ( PubMed, DOI )

  39. Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers. PLoS Pathog.. 2015.11; 11 (11): e1005247. ( PubMed, DOI )

  40. Akiko Koizumi, Tetsuo Sasano, Wataru Kimura, Yoshihiro Miyamoto, Takeshi Aiba, Taisuke Ishikawa, Akihiko Nogami, Seiji Fukamizu, Harumizu Sakurada, Yoshihide Takahashi, Hiroaki Nakamura, Tomoyuki Ishikura, Haruhiko Koseki, Takuro Arimura, Akinori Kimura, Kenzo Hirao, Mitsuaki Isobe, Wataru Shimizu, Naoyuki Miura, Tetsushi Furukawa. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur. Heart J.. 2015.10; ( PubMed, DOI )

  41. Chika Kadota, Takuro Arimura, Takeharu Hayashi, Taeko K Naruse, Sachio Kawai, Akinori Kimura. Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations. J. Hum. Genet.. 2015.10; 60 (10): 641-645. ( PubMed, DOI )

  42. Daisuke Sakurai, Yasumasa Iwatani, Hitoshi Ohtani, Taeko K Naruse, Hiroshi Terunuma, Wataru Sugiura, Akinori Kimura. APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics. 2015.04; 67 (4): 253-257. ( PubMed, DOI )

  43. Taisuke Ishikawa, Chuanchau J Jou, Akihiko Nogami, Shinya Kowase, Cammon B Arrington, Spencer M Barnett, Daniel T Harrell, Takuro Arimura, Yukiomi Tsuji, Akinori Kimura, Naomasa Makita. Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome. Circ Arrhythm Electrophysiol. 2015.04; 8 (2): 400-408. ( PubMed, DOI )

  44. Atsushi Tanaka, Shinsuke Yuasa, Giulia Mearini, Toru Egashira, Tomohisa Seki, Masaki Kodaira, Dai Kusumoto, Yusuke Kuroda, Shinichiro Okata, Tomoyuki Suzuki, Taku Inohara, Takuro Arimura, Shinji Makino, Kensuke Kimura, Akinori Kimura, Tetsushi Furukawa, Lucie Carrier, Koichi Node, Keiichi Fukuda. Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes. J Am Heart Assoc. 2014.11; 3 (6): e001263. ( PubMed, DOI )

  45. Naomasa Makita, Nobue Yagihara, Lia Crotti, Christopher N Johnson, Britt-Maria Beckmann, Michelle S Roh, Daichi Shigemizu, Peter Lichtner, Taisuke Ishikawa, Takeshi Aiba, Tessa Homfray, Elijah R Behr, Didier Klug, Isabelle Denjoy, Elisa Mastantuono, Daniel Theisen, Tatsuhiko Tsunoda, Wataru Satake, Tatsushi Toda, Hidewaki Nakagawa, Yukiomi Tsuji, Takeshi Tsuchiya, Hirokazu Yamamoto, Yoshihiro Miyamoto, Naoto Endo, Akinori Kimura, Kouichi Ozaki, Hideki Motomura, Kenji Suda, Toshihiro Tanaka, Peter J Schwartz, Thomas Meitinger, Stefan Kääb, Pascale Guicheney, Wataru Shimizu, Zahurul A Bhuiyan, Hiroshi Watanabe, Walter J Chazin, Alfred L George. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet. 2014.08; 7 (4): 466-474. ( PubMed, DOI )

  46. Seigo Okada, Yasuo Suzuki, Takuro Arimura, Akinori Kimura, Hiroko Narumi, Shunji Hasegawa. A novel de novo mutation of β-cardiac myosin heavy chain gene found in a twelve-year-old boy with hypertrophic cardiomyopathy. J. Genet.. 2014.08; 93 (2): 557-560. ( PubMed )

  47. Takushi Nomura, Hiroyuki Yamamoto, Naofumi Takahashi, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model. Biochem. Biophys. Res. Commun.. 2014.07; 450 (2): 942-947. ( PubMed, DOI )

  48. Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A. The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr). 2014.04; 36 (2): 933-943. ( PubMed, DOI )

  49. Akinori Kimura. Departure from the Hardy-Weinberg equilibrium. Gene. 2014.03; 537 (2): 357. ( PubMed, DOI )

  50. Taeko K Naruse, Hirofumi Akari, Tetsuro Matano, Akinori Kimura. Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques. Immunogenetics. 2014.03; 66 (3): 161-170. ( PubMed, DOI )

  51. Goro Katsuumi, Wataru Shimizu, Hiroshi Watanabe, Takashi Noda, Akihiko Nogami, Kimie Ohkubo, Takeru Makiyama, Naofumi Takehara, Yuichiro Kawamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Naomasa Makita, Tohru Minamino. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int. J. Cardiol.. 2014.03; 172 (2): 519-522. ( PubMed, DOI )

  52. Ayako Nishio, Yoshihiro Noguchi, Tatsuya Sato, Taeko K Naruse, Akinori Kimura, Akira Takagi, Ken Kitamura. A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss. Ann. Hum. Genet.. 2014.03; 78 (2): 83-91. ( PubMed, DOI )

  53. Nami Iwamoto, Naofumi Takahashi, Sayuri Seki, Takushi Nomura, Hiroyuki Yamamoto, Makoto Inoue, Tsugumine Shu, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Control of simian immunodeficiency virus replication by vaccine-induced Gag- and Vif-specific CD8+ T cells. J. Virol.. 2014.01; 88 (1): 425-433. ( PubMed, DOI )

  54. Teruki Sato, Takashi Suzuki, Hiroyuki Watanabe, Ayumi Kadowaki, Akiyoshi Fukamizu, Peter P Liu, Akinori Kimura, Hiroshi Ito, Josef M Penninger, Yumiko Imai, Keiji Kuba. Apelin is a positive regulator of ACE2 in failing hearts. J. Clin. Invest.. 2013.12; 123 (12): 5203-5211. ( PubMed, DOI )

  55. Takuro Arimura, Ryu Takeya, Taisuke Ishikawa, Tetsuhiro Yamano, Akiko Matsuo, Tetsuya Tatsumi, Tetsuya Nomura, Hideki Sumimoto, Akinori Kimura. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ. J.. 2013.12; 77 (12): 2990-2996. ( PubMed )

  56. Takuro Arimura, Kenji Onoue, Yumiko Takahashi-Tanaka, Taisuke Ishikawa, Masayoshi Kuwahara, Mitsutoshi Setou, Shuji Shigenobu, Katsushi Yamaguchi, Anne T Bertrand, Noboru Machida, Kazumi Takayama, Masayuki Fukusato, Ryo Tanaka, Satoshi Somekawa, Tomoya Nakano, Yoshihisa Yamane, Keiji Kuba, Yumiko Imai, Yoshihiko Saito, Gisèle Bonne, Akinori Kimura. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc. Res.. 2013.08; 99 (3): 382-394. ( PubMed, DOI )

  57. Claudia Crocini, Takuro Arimura, Silke Reischmann, Alexandra Eder, Ingke Braren, Arne Hansen, Thomas Eschenhagen, Akinori Kimura, Lucie Carrier. Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. Basic Res. Cardiol.. 2013.05; 108 (3): 349. ( PubMed, DOI )

  58. Kashiwakura Yuji, Sakurai Daisuke, Kanno Yumiko, Hashiguchi Masaaki, Kobayashi Ayano, Kurosu Akira, Tokudome Shogo, Kobata Tetsuji, Kojima Hidefumi. CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim. Immunology. 2013.05; 139 (1): 48-60. ( PubMed, DOI )

  59. An J, Kimura A. IkBL mapped within the HLA region is a novel regulator of alternative splicing involved in the pathogenesis of immune-related diseases. MHC. 2013; 20 (3): 191-197.

  60. Nakayama EE, Nakajima T, Kaur G, Miyama J, Terunuma H, Mehra NK, Kimura A, Shioda T. A naturally occurring single amino acid substitution in human TRIM5a linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection. AIDS Res Hum Retroviruses. 2013; 29 (6): 919-924. ( PubMed, DOI )

  61. Sakurai Daisuke, Zhao Jian, Deng Yun, Kelly Jennifer A, Brown Elizabeth E, Harley John B, Bae Sang-Cheol, Alarcomicronn-Riquelme Marta E, Edberg Jeffrey C, Kimberly Robert P, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vila Luis M, Alarcon Graciela S, Kaufman Kenneth M, Vyse Timothy J, Jacob Chaim O, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Kamen Diane L, Gilkeson Gary S, Niewold Timothy B, Merrill Joan T, Scofield R Hal, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Kim Jae-Hoon, Choi Jiyoung, Pons-Estel Bernardo A, Freedman Barry I, Anaya Juan-Manuel, Martin Javier, Yu C Yung, Chang Deh-Ming, Song Yeong Wook, Langefeld Carl D, Chen Weiling, Grossman Jennifer M, Cantor Rita M, Hahn Bevra H, Tsao Betty P, BIOLUPUS and GENLES networks. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 2013; 9 (10): e1003870. ( PubMed, DOI )

  62. Deng Yun, Zhao Jian, Sakurai Daisuke, Kaufman Kenneth M, Edberg Jeffrey C, Kimberly Robert P, Kamen Diane L, Gilkeson Gary S, Jacob Chaim O, Scofield R Hal, Langefeld Carl D, Kelly Jennifer A, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vila Luis M, Alarcon Graciela S, Vyse Timothy J, Pons-Estel Bernardo A, Freedman Barry I, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Gregersen Peter K, Anaya Juan-Manuel, Niewold Timothy B, Merrill Joan T, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Cantor Rita M, Chen Weiling, Grossman Jeniffer M, Hahn Bevra H, Harley John B, Alarcomicronn-Riquelme Marta E, Brown Elizabeth E, Tsao Betty P, Argentine Collaborative Group. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013; 9 (2): e1003336. ( PubMed, DOI )

  63. Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu MF, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M. Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet.. 2013; 6 (6): 569-578. ( PubMed, DOI )

  64. An J, Nakajima T, Shibata H, Arimura T, Yasunami M, Kimura A.. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene. J Autoimmun. 2013; In Press. ( PubMed, DOI )

  65. Chan K, Patel RS, Newcombe P, Nelsone CP, Qasim A, Epstein SE, Burnett S, Vaccarino V, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, Eddine N, Mokhtari NEE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Wittaker JC, Tang WHW, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards MA, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden - a collaborative meta-analysis. J Am Col Cardiol.. 2013; 61 (9): 957-970. ( PubMed, DOI )

  66. Sharma G, Ohtani H, Kaur G, Naruse TK, Sharma SK, Vajpayee M, KimuraA, Mehra NK. Status of TIM-1 exon 4 haplotypes and CD4+T cell counts in HIV-1 seroprevalent North Indians. Hum Immunol. 2013; 74 (2): 163-165. ( PubMed, DOI )

  67. Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T. A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques. PLos ONE. 2013; 8 (1): e54300. ( PubMed, DOI )

  68. Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J. 2013; 77 (4): 959-967. ( PubMed, DOI )

  69. Nakane T, Nomura T, Shi S, Nakamura M, Naruse TK, Kimura A, Matano T, Yamamoto H. Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques. PLoS ONE. 2013; 8 (9): e73453. ( PubMed, DOI )

  70. Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai1 R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am J Hum Genet. 2013; 93 (2): 289-297. ( PubMed, DOI )

  71. Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F. Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein. Rheumatol. 2013; 52 (10): 1769-1774. ( PubMed, DOI )

  72. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Similarities and differences in genetic and clinical characteristics between early repolarization syndrome and Brugada syndrome. Circ Arrhythm Electrophysiol. 2012; 5 (2): e60-e61. ( DOI )

  73. Xi Y, Ai T, De Lange E, Li Z, Wu G, Brunelli L, Kyle WB, Cheng J, Ackerman MJ, Kimura A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M. Loss-of-function of hNav1.5 by ZASP1-D117N associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol. 2012; 5 (5): 1017-1026. ( PubMed, DOI )

  74. Sato A, Sakamoto N, Ando K, Kaneshiro T, Uekita H, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Sato M, Tamagawa K, Arimura T, Kimura A, Takeishi Y. Dilated phase of hypertrophic cardiomyopathy caused by two different sarcomere mutations, treated with surgical left ventricular reconstruction and cardiac resynchronization therapy with a defibrillator. Intern Med. 2012; 51 (18): 2559-2564. ( PubMed, DOI )

  75. Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice. EMBO J. 2012; 31 (23): 4428-4440. ( PubMed, DOI )

  76. Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol. 2012; 5 (6): 1098-1107. ( PubMed, DOI )

  77. Tabara Y, Kohara K, Miki T; Millennium Genome Project for Hypertension (Fujioka A, Hanada H, Hata A, Hirawa N, Hiura Y, Imai Y, Inoko H, Itoh N, Iwai N, Kulski JK, Kamide K, Kato N, Osaka TK, Kawamoto R, Kawano Y, Kimura A, Kita Y, Kohara K, Kokubo Y, Mano H, Mano S, Miki T, Miyata T, Mizuki N, Morisaki T, Nakamura Y, Nakao K, Nakayama T, Nakura J, Ogawa M, Ogihara T, Ohkubo T, Ohno S, Oka A, Okamura T, Saruta T, Sekine A, Shiwa T, Soma M, Sugano S, Tabara Y, Tajima A, Takahashi N, Takashima N, Takeuchi F, Tokunaga K, Tomoike H, Umemura S, Yamane T, Yanai K, Yasunami M, Yatsu K, Yoshida T, Tabara Y). Hunting for genes for hypertension: the Millennium Genome Project for Hypertension. Hypertension Res. 2012; 35 (6): 567-573. ( PubMed, DOI )

  78. Ohtani H, Naruse TK, Iwasaki Y, Ishida T, Akari H, Matano T, Kimura A. Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates. Immunogenetics. 2012; 64 (9): 669-678. ( PubMed, DOI )

  79. Purevjav E, Arimura T, Augustin S, Huby A-C, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna W, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PMA, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA. Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet. 2012; 21 (9): 2039-2053. ( PubMed, DOI )

  80. Saito Y, Naruse TK, Akari H, Matano T, Kimura A. Diversity of MHC class I haplotypes in cynomolgus macaques. Immunogenetics. 2012; 62 (2): 131-141. ( PubMed, DOI )

  81. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Naomasa Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol. 2012; 159 (3): 238-240. ( PubMed, DOI )

  82. Otsuka H, Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A. Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy. Circ J. 2012; 76 (2): 453-461. ( PubMed, DOI )

  83. Nomura T, Terahara K, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T. Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques. J Virol.. 2012; 86 (12): 6481-6490. ( PubMed, DOI )

  84. Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T. Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques. J Virol.. 2012; 86 (2): 738-745. ( PubMed, DOI )

  85. Takaki A, Yamazaki A, Maekawa T, Shibata H, Hirayama K, Kimura A, Hirai H, Yasunami M. Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques. Immunogenetics. 2012; 64 (1): 15-29. ( PubMed, DOI )

  86. Naruse TK, Okuda Y, Mori K, Akari H, Matano T, Kimura A. ULBP4/RAET1E is highly polymorphic in the Old World monkey. Immunogenetics. 2011; 63 (8): 501-509. ( PubMed, DOI )

  87. Takahashi M, Chen Z, Watanabe K, Kobayashi H, Nakajima T, Kimura A, Izumi Y. Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese. Open Dent J. 2011; 5 190-194. ( PubMed, DOI )

  88. Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T. Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge. Biochem Biophys Res Commun. 2011; 408 (4): 615-619. ( PubMed, DOI )

  89. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 2011; 4 (6): 874-881. ( PubMed, DOI )

  90. Ohtani H, Nakajima T, Akari H, Ishida T, KimuraA. Molecular evolution of immunoglobulin superfamily genes in primates. Immunogenetics. 2011; 63 (7): 417-428. ( PubMed, DOI )

  91. Yanagimachi M, Miyamae T, Naruto T, Hara T, Kikuchi M, Hara R, Imagawa T, Mori M. Kaneko T, Goto H, Morita S, Mizuki N, Kimura A, Yokota S. Association of HLA-A*02:06 and DRB1*09:01 with clinical subtypes of juvenile idiopathic arthritis. J Hum Genet. 2011; 56 (3): 196-199. ( PubMed, DOI )

  92. Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL.. Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy. Circ J. 2011; 75 (11): 2654-2659. ( PubMed, DOI )

  93. Kimura A. Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy. Circ J. 2011; 75 (7): 1756-1765. ( PubMed, DOI )

  94. Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A. A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese. J Hum Genet. 2011; 56 (7): 545-547. ( PubMed, DOI )

  95. Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A. Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance the sensitivity to apoptosis in cardiomyocytes. Hum Mutat. 2011; 32 (12): 1481-1491. ( PubMed, DOI )

  96. Nakamura M, Takahara Y, Ishii H, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T, Matsuoka S. Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques. Microbiol Immuno. 2011; 55 (11): 768-773. ( PubMed, DOI )

  97. Shuno Yasutaka, Tsuno Nelson H, Okaji Yurai, Tsuchiya Takeshi, Sakurai Daisuke, Nishikawa Takeshi, Yoshikawa Naoyuki, Sasaki Kazuhito, Hongo Kumiko, Tsurita Giichiro, Sunami Eiji, Kitayama Joji, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer. J Surg Res. 2010.06; 161 (1): 76-82. ( PubMed, DOI )

  98. Kanno Yumiko, Sakurai Daisuke, Hase Hidenori, Kojima Hidefumi, Kobata Tetsuji. TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling. J Recept Signal Transduct Res. 2010.04; 30 (2): 121-132. ( PubMed, DOI )

  99. Kojima Hidefumi, Kobayashi Ayano, Sakurai Daisuke, Kanno Yumiko, Hase Hidenori, Takahashi Riichi, Totsuka Yoshikazu, Semenza Gregg L, Sitkovsky Michail V, Kobata Tetsuji. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol. 2010.01; 184 (1): 154-163. ( PubMed, DOI )

  100. Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A. Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model. J Am Coll Cardiol. 2010; 55 (14): 1503-1505. ( PubMed, DOI )

  101. Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010; 56 (18): 1493-1502. ( PubMed, DOI )

  102. Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A. Diversity of MHC class I genes in Burmese-origin rhesus macaque. Immunogenetics. 2010; 62 (9): 601-611. ( PubMed, DOI )

  103. Hitomi N, Kubo T, Kitaoka H, Hirota T, Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL. A frameshift deletion mutation in the cardiac myosin-binding protein C gene was associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. J Cardiol. 2010; 56 (2): 189-196. ( PubMed, DOI )

  104. Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K.. A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Biochim Biophys Acta. 2010; 1800 (1): 31-39. ( PubMed, DOI )

  105. Neely1 GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010; 141 (1): 142-153. ( DOI )

  106. Li Z, Ai T, Samani K, Xi Y, Tzeng HP, Xie M, Taylor MD, Wu S, Ge S, Dong JW. Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M.. ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circulation Arrhythm Electrophisiol. 2010; 3 (6): 646-656. ( PubMed, DOI )

  107. Shichi D, Arimura T, Ishikawa T, Kimura A. Heart-specific small subunit of myosin light chain phosphatase activates Rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1. J Biol Chem. 2010; 285 (44): 33680-33690. ( PubMed, DOI )

  108. Takahashi M, Kimura A. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves disease. J Hum Genet. 2010; 55 (5): 323-326. ( PubMed, DOI )

  109. Kimura A. Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond. J Hum Genet. 2010; 55 (2): 81-90. ( PubMed, DOI )

  110. Wichukchinda N, Nakajima T, Saipradit N, Nakayama EE, Ohtani H, Rojanawiwat A, Pathipvanich P, Ariyoshi K, Sawanpanyalert P, Shioda T, Kimura A. TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand. AIDS. 2010; 24 (11): 1625-1631. ( PubMed, DOI )

  111. Sugimoto C, Watanabe S, Naruse T, Kajiwara E, Shiino T, Umano N, Ueda K, Sato H, Ohgimoto S, Hirsh V, Villinger F, Ansari AA, Kimura A, Miyazawa M, Suzuki Y, Yamamoto N, Nagai Y, Mori K. Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV. PLoS ONE. 2010; 5 (7): e11678. ( PubMed, DOI )

  112. Choi JO, You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE. Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations. Clin Cardiol. 2010; 33 (7): 430-438. ( PubMed, DOI )

  113. Chen Z, Nakajima T, Tanabe N, Hinohara K, Sakao S, Kasahara Y, Tatsumi K, Inoue Y, Kimura A. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene. Hum Genet. 2010; 128 (4): 443-452. ( PubMed, DOI )

  114. An J, Nakajima T, Kuba K, Kimura A. Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage. Hypertension Res. 2010; 33 (8): 831-835. ( PubMed, DOI )

  115. Itaya S, Nakajima T, Kaur G, Terunuma H, Ohtani H, Mehra N, Kimura A. No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. J Infect Dis. 2010; 202 (5): 815-816. ( PubMed, DOI )

  116. Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Hirasawa EA, Hattori N, Nishino I, Kimura A. Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy. Circ J. 2009; 73 (1): 158-161. ( DOI )

  117. Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya J, Ohtani H, Mehra N, Shioda Y, Kimura A. Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS. 2009; 23 (16): 2091-2100. ( PubMed, DOI )

  118. Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse T, Kimura A. Complex divergence at a microsatellite marker C1_2_5 in lineage of HLA-Cw/-B haplotype. J Hum Genet. 2009; 54 (4): 224-229. ( DOI )

  119. Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A. Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 2009; 54 (2): 115-121. ( DOI )

  120. Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.. Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease. J Hum Genet.. 2009; 54 (11): 642-646. ( PubMed, DOI )

  121. Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 2009; 83 (1): 80-88. ( DOI )

  122. Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. J Hum Genet. 2009; 54 (2): 108-114. ( DOI )

  123. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. J Hum Genet. 2009; 54 (4): 248-251. ( DOI )

  124. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.. Validation of the association between AGTRL1 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet. 2009; 54 (9): 554-556. ( DOI )

  125. Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD -the gene encoding cardiac ankyrin repeat protein- is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 2009; 54 (4): 325-333. ( PubMed, DOI )

  126. Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE,, Izumi T, Kimura A. Megakaryoblastic leukemia factor-1gene in the susceptibility to coronary artery disease. Hum Genet.. 2009; 126 (4): 539-547. ( PubMed, DOI )

  127. Arimura T, Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A. Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009; 54 (4): 334-342. ( PubMed, DOI )

  128. Kimura A. Does a gene polymorphism predisposing to the intermediate phenotype predict the risk of disease? Circ J. 2009; 73 (6): 1016-1017. ( PubMed, DOI )

  129. Kano T, Mori T, Kimura A. Gender ratio distortion in abortuses and live births from patients with recurrent spontaneous abortion. Am J Reprod Immunol. 2009; 62 (3): 125-127. ( PubMed, DOI )

  130. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A.. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J Biol Chem. 2009; 284 (50): 35122-35133. ( PubMed, DOI )

  131. Hase Hidenori, Kanno Yumiko, Kojima Hidefumi, Sakurai Daisuke, Kobata Tetsuji. Coculture of osteoclast precursors with rheumatoid synovial fibroblasts induces osteoclastogenesis via transforming growth factor beta-mediated down-regulation of osteoprotegerin. Arthritis Rheum. 2008.11; 58 (11): 3356-3365. ( PubMed, DOI )

  132. Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban J, Yasunami M, Park JE, Izumi T, Kimura A. Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations J Hum Genet. 2008; 53 (4): 357-359.

  133. Nakajima T, Kimura A. Genetic factors which confer sensitivity to highly active antiretroviral therapy (HAART) in HIV-infected subjects - implication of a benefit of an earlier initiation of HAART in HIV therapy Pharmacogenomics. 2008; 9 (9): 1347-1351.

  134. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Hohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakamura T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project Hum Mol Genet. 2008; 17 (4): 617-627.

  135. Takemoto Y, Naruse TK, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Shams H, Davatchi F, Inoko H, Ohno S, Kimura A. Re-evaluation of heterogeneity in HLA-B510101 associated with Behcet's disease Tissue Antigens. 2008; 72 (4): 347-353.

  136. Kimura A. Molecular etiology and pathogenesis of hereditary cardiomyopathy Circ J. 2008; 72 (Suppl A): A38-48.

  137. Tsukamoto T, Dohki S, Ueno T, Kawada M, Takeda A, Yasunami M, Naruse T, Kimura A, Takiguchi M, Matano T. Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope AIDS. 2008; 22 (8): 993-994.

  138. Shichi D, Matsumori A, Naruse TK, Inoko H, Kimura A. HLA-DP beta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy Int J Immunogenet. 2008; 35 (1): 37-43.

  139. Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A. Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics. 2008; 60 (12): 727-735. ( DOI )

  140. Nakajima T, Kaur G, Mehra NK, Kimura A. HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5. Cytogenet Genome Res. 2008; 123 (1-4): 156-160. ( DOI )

  141. Sakurai Daisuke, Hase Hidenori, Kanno Yumiko, Kojima Hidefumi, Okumura Ko, Kobata Tetsuji. TACI regulates IgA production by APRIL in collaboration with HSPG. Blood. 2007.04; 109 (7): 2961-2967. ( PubMed, DOI )

  142. Sakurai Daisuke, Kanno Yumiko, Hase Hidenori, Kojima Hidefumi, Okumura Ko, Kobata Tetsuji. TACI attenuates antibody production costimulated by BAFF-R and CD40. Eur J Immunol. 2007.01; 37 (1): 110-118. ( PubMed, DOI )

  143. Munehisa Y, Watanabe H, Kosaka T, Kimura A, Ito H. Successful outcome in a pregnant woman with isolated noncompaction of the left ventricular myocardium Intern Med. 2007; 46 (6): 285-289.

  144. Aizawa Y, Mitsuma W, Ikrar T, Komura S, Hanawa H, Miyaima S, Miyoshi F, Kobayashi Y, Chinushi M, Kimura A, Hiraoka M, Aizawa Y. Human cardiac ryanodine receptor mutations in ion channel disorders in Japan Int J Cardiol. 2007; 116 (2): 263-265.

  145. Takahashi-Tanaka Y, Yasunami M, Naruse T, Hinohara K, Matano T, Mori K, Miysazawa M, Honda M, Yasutomi Y, Nagai Y, Kimura A. Reference strand-mediated conformation analysis (RSCA)-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci Electrophoresis. 2007; 28 (6): 918-924.

  146. Yatsu K, Mizuki N, Hirata N, Oka A, Ito N, Yamane T, Ogawa M, Shiwa T, Tabara Y, Ohno S, Soma M, Hata A, Nakano K, Ueshima H, Ogiwara T, Tomoike H, Miki T, Kimura A, Mano S, Kulski JK, Umemura S, Inoko H. High-resolution mapping for essential hypertension using microsatellite markers Hypertension. 2007; 49 (3): 446-452.

  147. Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrabdt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenoviv V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload Circ Res. 2007; 101 (4): e32-e42.

  148. Nouchi T, Yasunami M, Mibu R, Yasunaga S, Itoh-Satoh M, Takahashi M, Tanaka S, Kuwano H, Kimura A. Somatic mutations leading to incomplete extinction of HLA class I were associated with replication error phenotype-positive colorectal carcinoma MHC. 2007; 13 (3): 187-197.

  149. Knoell R, Postel R, Wang J, Kraetzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Dieter K, Gudrun K, Schaefer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nuemberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Hertog JD, van Eeden F, Peters P, Hasenfuss G, Chien KR, Bakkers J. Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells Circulation. 2007; 116 (5): 515-525.

  150. Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T. Vaccine-based long-term stable control of simian-human immunodeficiency virus 89-6PD replication in rhesus macaques J Gen Virol. 2007; 88 (Pt2): 652-659.

  151. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy Am J Physiol Heart Card Physiol. 2007; 293 (6): H3396-H3403.

  152. Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Itoh-Satoh M, Bonne G, Schwartz K, Kimura A. Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy Biochem Biophys Res Commun. 2007; 357 (1): 162-167.

  153. Kano T, Mori T, Furudono M, Tamura I, Ishikawa H, Watanabe H, Kikkawa E, Warita T, Kawada H, Onizuka M, Takahashi M, Maeda Y, Naruse T, Inoko H, Kimura A. HLA may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapy Am J Reprod Immunol. 2007; 58 (4): 383-387.

  154. Chen Z, Takahashi M, Naruse T, Nakajima T, Chen YW, Inoue Y, Ishilkawa I, Iwai T, Kimura A. Synergistic contribution of CD14 and HLA loci to the susceptibility to Buerger disease Hum Genet. 2007; 122 (3-4): 367-372.

  155. Nakamura K, Katayama Y, Kusano KF, Haraoka K, Tani Y, Nagase S, Morita H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T. Anti-KCNH2 Antibody-induced long QT syndrome: novel acquired form of long QT syndrome J Am Coll Cardiol. 2007; 50 (18): 1808-1809.

  156. Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Pollevick GD, Sicouri S, Sato A, Nagata Y, Iesaka Y, Aizawa Y, Kimura A, Hiraoka M, Anzelevitch C. A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome J Cardiovasc Electrophysiol. 2007; 18 (9): 972-977.

  157. Maehata Y, Takamizawa S, Ozawa S, Izukuri K, Kato Y, Sato S, Lee MC, Kimura A, Hata R. Type III collagen is essential for growth acceleration of human osteoblastic cells by ascorbic acid 2-phosphate, a long-acting vitamin C derivative Matrix Biol. 2007; 26 (5): 371-381.

  158. Kimura A, Takahashi M, Choi BY, Bae SW, Hohta S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Naruse T, Izumi T, Park JE. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations Tissue Antigens. 2007; 69 (3): 265-269.

  159. Sugimori C, Yamazaki H, Feng X, Mochizuki K, Kondo Y, Takami A, Chuhjo T, Kimura A, Teramura M, Mizoguchi H, Omine M, Nakao S. Roles of DRB11501 and DRB11502 in the pathogenesis of aplastic anemia Exp Hematol. 2007; 35 (1): 13-20.

  160. Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, Kiyosawa K, Fukushima H, Bahram S, Inoko H, Kawa S. Two critical genes (HLA-DRB1 andABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis Immunogenetics. 2007; 59 (1): 45-52.

  161. Arimura T, Matsumoto Y, Okazaki O, Hayashi T, Takahashi M, Inagaki N, Hinohara K, Ashizawa N, Yano K, Kimura A. Structural analysis of obscurin gene in hypertrophic cardiomyopathy Biochem Biophys Res Commun. 2007; 362 (2): 281-287.

  162. Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya J, Terunuma H, Kimura A. Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia Immunogenetics. 2007; 59 (10): 793-798.

  163. Arimura T, Hayashi T, Kimura A. Molecular etiology of idiopathic cardiomyopathy Acta Myologica. 2007; 26 (3): 153-158.

  164. Okaji Yurai, Tsuno Nelson Hirokazu, Kitayama Joji, Sakurai Daisuke, Tsuchiya Naoyuki, Saito Shinsuke, Takegami Kenji, Tsuchiya Takeshi, Kawai Kazushige, Yazawa Kentaro, Asakage Masahiro, Yoneyama Satomi, Yamada Jun, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Effects of down-regulating the Id genes in human colorectal cancer cells on early steps of haematogenous metastasis. Eur J Cancer. 2006.03; 42 (5): 668-673. ( PubMed, DOI )

  165. Takahashi M, Yasunami M, Kubota S, Tamai H, Kimura A. HLA-DPB10202 is associated with a predictor of good prognosis of Graves disease in Japanese Hum Immunol. 2006; 67 (1-2): 47-52.

  166. Inagaki N, Hayashi T, Arimura T, Koga Y, Takahashi M, Shibata H, Teraoka K, Chikamori T, Yamashina A, Kimura A. ?B-crystallin mutation in dilated cardiomyopathy Biochem Biophys Res Commun. 2006; 342 (2): 379-386.

  167. Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, Kimura A. Direct determination of SNP haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases Hum Immunol. 2006; 67 (4-5): 363-373.

  168. Tsuchiya Takeshi, Okaji Yurai, Tsuno Nelson H, Sakurai Daisuke, Tsuchiya Naoyuki, Kawai Kazushige, Yazawa Kentaro, Asakage Masahiro, Yamada Jun, Yoneyama Satomi, Kitayama Joji, Osada Takuya, Watanabe Toshiaki, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. Cancer Sci. 2005.11; 96 (11): 784-790. ( PubMed, DOI )

  169. Nakamura Naoya, Hase Hidenori, Sakurai Daisuke, Yoshida Sachiko, Abe Masafumi, Tsukada Nobuhiro, Takizawa Jun, Aoki Sadao, Kojima Masaru, Nakamura Shigeo, Kobata Tetsuji. Expression of BAFF-R (BR 3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody. Virchows Arch. 2005.07; 447 (1): 53-60. ( PubMed, DOI )

  170. Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, ArimuraT, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano K, Kimura A. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy J Muscle Res Cell Motil. 2005; 26 (6-8): 367-374.

  171. Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T. Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan Eur Resp J. 2005; 25 (1): 131-138.

  172. Munkanta M, Terunuma H, Takahashi M, Hanabusa H, Miura T, Ikeda S, Sakai M, Fujii T, Takahashi Y, Oka S, Matsuda J, Ishikawa M, Takashima Y, Mimaya J, Ito M, Kimura A, Yasumani M. HLA-B polymorphism in Japanese HIV-1 infected long-term surviving hemophiliacs Viral Immunol. 2005; 18 (3): 500-505.

  173. Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Spontaneous T wave alterans in a patient with Brugada syndrome - responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing J Cardiovasc Electrophysiol. 2005; 16 217-220.

  174. Kubo T, Kitaoka H, Okawa M, Matsumura Y, Hitomi N, Yamazaki N, Furuno T, Takata J, Nishinaga M, Kimura A, Doi YL. Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac myosin-binding protein C gene J Am Coll Cardiol. 2005; 46 (9): 1737-1743.

  175. Noguchi Y, Yashima T, Hatanaka A, Uzawa M, Yasunami M, Kimura A, Kitamura K. A mutation in WFS1 in a Japanese family with autosomal dominant low-frequency sensorineural hearing loss Acta Oto-Laryngol. 2005; 125 (11): 1189-1194.

  176. Shichi D, Kikkawa FE, Ota M, Katsuyama Y, Kimura A, Matsumori A, Kulsky JK, Naruse KT, Inoko H. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus associated dilated cardiomyopathy Tissue Antigens. 2005; 66 (3): 200-208.

  177. Mori K, Sugimoto C, Ohgimoto S, Nakayama EE, Shinoda T, Kusagasa S, Takebe Y, Kano M, Matano T, Yuasa T, Kitagawa D, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, Yamamoto N, Suzuki Y, Nagai Y. Influence of glycosylation on the efficacy of an Env-based vaccine against SIVmac239 in a macaque AIDS model J Virol. 2005; 79 (16): 10386-10389.

  178. Aizawa Y, Ueda K, Komura S, Washizuka T, Chinushi M, Inagaki N, Matsumoto Y, Hayashi T, Takahashi M, Nakano N, Yasunami M, Kimura A, Hiraoka M, Aizawa Y. A novel mutation in FKBP12-6 binding region of the human cardiac ryanodine receptor gene (R2401H) in Japanese patient with catecholaminergic polymorphic ventricular tachycardia Int J Cardiol. 2005; 99 (2): 343-345.

  179. Sakurai Daisuke, Tsuchiya Naoyuki, Yamaguchi Akihiro, Okaji Yurai, Tsuno Nelson H, Kobata Tetsuji, Takahashi Koki, Tokunaga Katsushi. Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J Immunol. 2004.11; 173 (9): 5801-5809. ( PubMed )

  180. Hase Hidenori, Kanno Yumiko, Kojima Masaru, Hasegawa Kaoru, Sakurai Daisuke, Kojima Hidefumi, Tsuchiya Naoyuki, Tokunaga Katsushi, Masawa Nobuhide, Azuma Miyuki, Okumura Ko, Kobata Tetsuji. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood. 2004.03; 103 (6): 2257-2265. ( PubMed, DOI )

  181. Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K. 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene Circ J. 2004; 68 174-177.

  182. Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M. Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking FEBS Lett. 2004; 574 (1-3): 145-150.

  183. Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K. The role of a common TNNT2 polymorphism in cardiac hypertrophy J Hum Genet. 2004; 49 129-133.

  184. Matano T, Kobayashi M, Igarashi H, Takeda A, Nakamura H, Kano M, Sugimoto C, Mori K, Iida A, Hirata T, Hasegawa M, Yuasa T, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, O'Connor DH, Watkins DI, Nagai Y. Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial J Exp Med. 2004; 199 (12): 1709-1718.

  185. Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A. Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia J Biol Chem. 2004; 279 (26): 27194-27198.

  186. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Kn?ll R, Hoshijima M, Chien KR, Kimura A. TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy J Am Coll Cardiol. 2004; 44 (11): 2192-2201.

  187. Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H. Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes Diabet Res Clin Pract. 2004; 66 (2): 163-171.

  188. Hayashi T, Arimura T, Ueda K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A. Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy Biochem Biophys Res Commun. 2004; 313 (1): 178-184.

  189. Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese Tissue Antigens. 2004; 63 223-230.

  190. Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A. A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C J Biol Chem. 2004; 279 (8): 6746-6752.

  191. Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M. Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation J Mol Cell Cardiol. 2004; 37 (6): 1205-1211.

  192. Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access Mol Pharmacol. 2004; 66 330-336.

  193. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H. Identification of IkBL as the second MHC-linked susceptibility locus for rheumatoid arthritis Am J Hum Genet. 2003; 72 303-312.

  194. Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A. Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese MHC. 2003; 9 163-169.

  195. Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T. Association study of the CD14 polymorphism with myocardial infarction in Japanese populations Jpn Heart J. 2003; 44 (5): 613-622.

  196. Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions Arter Thrombo Vasc Biol. 2003; 23 783-788.

  197. Kuroda N, Ohnishi Y, Kimura A, Yokoyama M. Clinical significance of T-wave alternans in hypertrophic cardiomyopathy Circ J. 2002; 66 457-462.

  198. Knoell R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy Cell. 2002; 111 943-955.

  199. Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M. Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy J Allergy Clin Immunol. 2002; 110 652-658.

  200. Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M. Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene J Hum Genet. 2002; 47 330-332.

  201. Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A. A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease Cardiovasc Res. 2002; 53 348-354.

  202. Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S. Analysis of HLA in children with gelatin allergy Tissue Antigens. 2002; 59 412-416.

  203. Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A. Titin mutations as the molecular basis for dilated cardiomyopathy Biochem Biophys Res Commun. 2002; 291 (2): 385-393.

  204. Matsumori A, Furukawa Y, Hasegawa K, Sato Y, Nakagawa H, Morikawa Y, Miura K, Ohno Y, Inaba Y, Sasayama S, Fujiwara H, Hiroe M, Hori M, Imaizumi T, Inoko H, Izumi T, Kawai S, Kawana M, Kimura A, Kitabatake A, Kitamura S, Kitaura Y, Matsuzaki M, Nagai R, Ogawa S, Shimada T, Simotohno K, Takeda N, Takihara K, Tanaka M, Tei T, Toyo-oka T, Yamaguchi I, Yokoyama M, Yutani C. Epidemiologic and clinical characteristics of cardiomyopathies in Japan - Analysis by nationwide surveys Circ J. 2002; 66 323-336.

  205. Sakurai D, Yamaguchi A, Tsuchiya N, Yamamoto K, Tokunaga K. Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Biochem Biophys Res Commun. 2001.06; 284 (2): 436-442. ( PubMed, DOI )

  206. Wakui M, Yamaguchi A, Sakurai D, Ogasawara K, Yokochi T, Tsuchiya N, Ikeda Y, Tokunaga K. Genes highly expressed in the early phase of murine graft-versus-host reaction. Biochem Biophys Res Commun. 2001.03; 282 (1): 200-206. ( PubMed, DOI )

  207. Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region Genomics. 2001; 71 263-270.

  208. Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese Ann NY Acad Sci. 2001; 947 259-269.

  209. Soejima T, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T. Isolation of novel heart-specific genes using the bodymap Genomics. 2001; 74 115-120.

  210. Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A. Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit J Biol Chem. 2001; 276 6073-6082.

  211. Fukuda Y, Hoshino S, Shintaku S, Tanaka I, Dohi K, Kimura A. HLA-DMB polymorphism in living-related kidney transplantation Transpl Proc. 2001; 33 3302-3308.

  212. Lee WH, Hwang TH, Kimura A, Park SW, Satoh M, Nishi H, Harada H, Toyama J, Park JE. Different expressivity of a ventricular essential light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy Am Heart J. 2001; 141 184-189.

  213. Kimura A, Itoh-Satoh M, Hayashi T, Takahashi M, Arimura T. Molecular etiology of idiopathic cardiomyopathy in Asian populations J Cardiol. 2001; 37 (Suppl): 139-146.

  214. Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A. Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4 Tissue Antigens. 2001; 57 520-535.

  215. Ubalee R, Suzuki F, Kikuchi M, Tasanor O, Wattanagoon Y, Ruangweerayut II R, Na-Bangchang K, Karbwang J, Kimura A, Ito K, Kanda T, Hirayama K. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar Tissue Antigens. 2001; 58 407-410.

  216. Tsuchiya K, Kimura A, Kondo M, Nishimura Y, Sasazuki T. Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis Tissue Antigens. 2001; 58 395-401.

  217. Matsuzoe D, Hideshima T, Iwasaki A, Yoneda S, Kawahara K, Shirakusa T, Kimura A. Glutathione S-transferase nu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers Carcinogenesis. 2001; 22 1327-1330.

  218. Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A. Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese Tissue Antigens. 2001; 57 66-69.

  219. Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, Na-Bangchang K, Kimura A, Aikawa M, Hirayama K. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais Parasitol Int. 2001; 50 235-239.

  220. Furuse M, Kimura A, Esaki M, Jo Y, Matsumoto T, Fujishima M. Polymorphism of the heat-shock protein gene HSP70-2 in ulcerative colitis MHC. 2000; 7 2-6.

  221. Hamaguchi K, Kimura A, Seki N, Higuchi T, Yasunaga S, Takahashi M, Sasazuki T, Kusuda Y, Okeda T, Itoh K, Sakata T. Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese Tissue Antigens. 2000; 55 10-15.

  222. Kamizono S, Yamada K, Seki N, Higuchi T, Kimura A, Nonaka K, Itoh K. Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene Tissue Antigens. 2000; 55 449-452.

  223. Kamizono S, Hiromatsu Y, Seki N, Bednarczuk T, Matsumoto H, Kimura A, Itoh K. A polymorphism of the 5' flanking region of tumor necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese Clin Endocrinol. 2000; 52 759-764.

  224. Aida K, Juarez S, Kikuchi M, Gil M, Ayau O, DeLopez MP, Kaneko S, Yanagi T, Obispo T, Velasquez E, Jianbing M, Matta V, Paz M, Kimura A, Itoh K, Tada I, Hirayama K. HLA-B35 and MICA-A5 synergistically enhanced the susceptibility to Chagas disease, Trypanozoma cruzi infection MHC. 2000; 7 63-70.

  225. Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, Nakazawa K, Kimura A, Hiraoka M. A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome FEBS Lett. 2000; 479 29-34.

  226. Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A. Characterization of human nebulette gene: A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy Hum Genet. 2000; 107 440-451.

  227. Hata R, Akai J, Kimura A, Ishikawa O, Kuwana M, Sinkai H. Association of functional microsatellites in the human type 1 collagen alpha2 chain (COL1A2) gene with systemic screlosis Biochem Biophys Res Commun. 2000; 272 36-40.

  228. Akai J, Kimura A, Hata R. Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha2 chain (COL1A2) gene promoter Connective Tissue. 2000; 32 259-265.

  229. Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F. Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis Int J Cardiol. 2000; 75 105-110.

  230. Matsuzoe D, Hideshima T, Ohshima K, Kawahara K, Shirakusa T, Kimura A. Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation Br J Cancer. 1999; 79 1549-1552.

  231. Seki N, Kamizono S, Yamada A, Matsumoto H, Niiya F, Kimura A, Tsuchiya K, Suzuki R, Date Y, Tomita T, Itoh K, Ochi T. Polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in patients with rheumatoid arthritis Tissue Antigens. 1999; 54 194-197.

  232. Fukuma K, Marubayashi S, Okda K, Yamada K, Kimura A, Dohi K. Effect of lazaroid U-74389G and methylpredonisolone on endotoxin-induced shock in mice Surgery. 1999; 125 421-430.

  233. Wang LM, Kimura A, Satoh M, Mineshita S. HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy Int J Lepr. 1999; 67 403-408.

  234. Matsuzoe D, Hideshima T, Kimura A, Inada K, Watanabe K, Akita Y, Kawahara K, Shirakusa T. p53 mutations predict non-small cell lung carcinoma response to radiotherapy Cancer Lett. 1999; 135 189-194.

  235. Satoh M, Takahashi M, Sakamoto T, Hiroe M, Marumo F, Kimura A. Structural analysis of the titin gene in hypertrophic cardiomyopathy - Identification of a novel disease gene Biochem Biophys Res Commun. 1999; 262 411-417.

  236. Yoshitake S, Okada M, Kimura A, Sasazuki T. Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobactor Pyroli related diseases Eur J Gastroenterol Hepatol. 1999; 11 875-880.

  237. Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with non-familial idiopathic dilated cardiomyopathy in Japanese Biochem Biophys Res Commun. 1999; 261 332-339.

  238. Doi YL, Kitaoka H, Hitomi N, Satoh M, Kimura A. Clinical expression in patients with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutation Circulation. 1999; 100 448-449.

  239. Takahashi M, Kobayashi Y, Ichiki M, Ouchi H, Numano F, Kimura A. HLA-linked susceptibility and resistance to Buerger's disease in Japanese MHC. 1999; 5 7-12.

  240. Akai J, Kimura A, Hata R. Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats Gene. 1999; 239 65-73.

  241. Yoshitake S, Kimura A, Okada M, Yao T, Sasazuki T. HLA class II alleles in Japanese patients with inflammatory bowel disease Tissue Antigens. 1999; 53 350-358.

  242. Djoulah S, Busson M, Sasazuki T, Maillere B, Yasunaga S, Kimura A, Charron D, Hors J. A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 and HLA-DQB1 pockets Tissue Antigens. 1999; 54 341-148.

  243. Date Y, Seki N, Kamizono S, Higuchi T, Miyata K, Ohkuni M, Tatsuzawa O, Yokota S, Joo K, Ueda K, Joo K, Kimura A, Itoh K, Kato H. Identification of genetic risk factor for systemic rheumatoid arthritis in the 5'-flanking region of the TNF-alpha gene and HLA genes Arthr Rheumat. 1999; 42 2577-2582.

  244. Shirai T, Hattori S, Sakaguchi M, Inoue S, Kimura A, Ebihara T, Irie S, Nagai R, Hori H. The complete cDNA coding sequence for the bovine proalpha2(I) chain of type I procollagen Matrix Biol. 1998; 17 85-88.

  245. Hata R, Akai J, Kimura A. Cell position dependent reciprocal feedback regulation of type I collagen gene expression in cultured human skin fibroblasts Cell Biol Internat. 1998; 22 85-191.

  246. Nomura Y, Kitteringham N, Shia K, Goseki M, Kimura A, Mineshita S. Use of the highly sensitive PCR method to detect the herpes Simplex Virus type 1 genome from Behchet disease patients J Med Dent Sci. 1998; 45 51-58.

  247. Kimura A, Kobayashi Y, Takahashi M, Ohbuchi N, Kitamura H, Satoh M, Nakamura T, Sasaoka T, Hiroi S, Aerbajinai W, Yasukochi Y, Numano F. MICA gene polymorphism in Takayasu arteritis and Buerger disease Int J Cardiol. 1998; 66S 107-113.

  248. Matsumori A, Ohashi N, Sasayama S, Eto T, Fujisawa H, Imaizumi T, Izumi T, Kawamura K, Kawana M, Kimura A, Kitabatake A, Matsuzaki M, Nagai R, Tanaka H, Hiroe M, Hori M, Inoko H, Seko Y, Sekiguchi M, Shimotohno T, Sugishita Y, Takeda N, Takihara K, Tanaka M, Tokuhisa T, Toyooka T, Yokoyama M. Hepatitis C virus infection and cardiomyopathies: A multicenter study in Japan Jpn Circ J. 1998; 62 389-391.

  249. Akai J, Kimura A, Arai K, Uehara K, Hata R. Fine structural analysis of the unique 5' region of human COL1A2 gene containing two regions of di-nucleotide repeats adjacent to the transcriptional start site Connective Tissue. 1998; 30 1-6.

  250. Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F, Kimura A, Kato H, Imaizumi T. Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy Circ Res. 1998; 83 594-601.

  251. Higuchi T, Seki N, Kamizono S, Yamada A, Kimura A, Kato H, Itoh K. Polymorphism of the 5'-flanking region of human tumor necrosis factor (TNF)-alpha gene in Japanese Tissue Antigens. 1998; 51 605-612.

  252. Zeki K, Tanaka Y, Morimoto I, Nishimura Y, Kimura A, Yamashita U, Eto S. Induction of expression of MHC-class-II antigen on human thyroid carcinoma by wild-type p53 Int J Cancer. 1998; 75 391-395.

  253. Kitamura H, Kobayashi Y, Kimura A, Numano F. Association of clinical manifestations with HLA-B alleles in Takayasu arteritis Int J Cardiol. 1998; 66S 121-126.

  254. Ikeda M, Orimo H, Moriyama H, Yoshitaka T, Matsubara N, Mibu R, Tanaka N, Shimada T, Kimura A, Shimizu K. Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability Cancer Res. 1998; 58 594-598.

  255. Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor N Engl J Med. 1998; 339 1177-1185.

  256. Hwang T, Lee W, Kimura A, Satoh M, Nakamura T, Kim M, Choi S, Park J. Early expression of a malignant phenotype of familial hypertrophic cardiomyopathy associated with a Gly716Arg myosin heavy chain mutation in a Korean family Am J Cardiol. 1998; 82 1509-1513.

  257. Macaubas C, Jin L, Hallmeyer J, Kimura A, Mignot E. The complex mutation pattern of a microsatellite Genome Research. 1997; 7 635-641.

  258. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Shintaku S, Ohdan H, Miyata H, Dohi K. Induction of donor-specific hyporeactivity in augmented microchimerism in rat liver transplantation followed by donor bone marrow Transplant Proc. 1997; 29 1196-1197.

  259. Ohdan H, Fukuda Y, Shintaku S, Miyata Y, Tashiro H, Hoshino S, Sumimoto R, Asahara T, Kimura A, Dohi K. Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation Transplant Proc. 1997; 29 925-927.

  260. Ohsuzu F, Katsushika S, Akanuma M, Nakamura H, Harada H, Satoh M, Hiroi S, Kimura A. Hypertrophic obstructive cardiomyopathy due to a novel T-to-A transition at codon 624 in the beta-myosin heavy chain (beta-MHC) gene possibly related to the sudden death Int J Cardiol. 1997; 62 203-209.

  261. Lin L, Jin L, Kimura A, Carrington M, Mignot E. DQ microsatellite association studies in three ethnic groups Tissue Antigens. 1997; 50 507-520.

  262. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K. Correlation of high-level microchimerism with graft acceptance in rat liver transplantation Transplant Proc. 1997; 29 1230-1231.

  263. Mignot E, Kimura A, Latterman A, Lin X, Yasunaga S, Rattazzi C, Jin L, Guilleminault C, Grumet FC, Dement WC, Underhill P. Extensive HLA class II studies in 58 non DRB115 (DR2) narcoleptic patients with cataplexy maps susceptibility to the coding region of DQA10102 and DQB10602 gene Tissue Antigens. 1997; 49 329-341.

  264. Miyata Y, Ohdan H, Noriyuki T, Shintaku S, Shibata S, Yamamoto H, Yoshioka S, Asahara T, Fukuda Y, Kimura A, Dohi K. Analysis of xenogeneic microchimerism in hamster-to-rat lung xenotransplantation Transplant Proc. 1997; 29 3505-3507.

  265. Munkhbat B, Sato T, Hagihara M, Tsuchida F, Sato K, Kimura A, Munkhtuvshin N, Tsuji K. Molecular analysis of HLA polymorphism in Khoton-Mongolians Tissue Antigens. 1997; 50 124-134.

  266. Kimura A, Harada H, Park J, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang T, Choo J, Chung K, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy Nature Genet. 1997; 16 379-382.

  267. Kimura A. Molecular genetics of hypertrophic cardiomyopathy in Japan Internal Med. 1997; 36 152-154.

  268. Mori K, Sasazuki T, Kimura A, Ito Y. HLA-DP antigens and poststrreptococcal acute glomerulonephritis in Japan Acta Paediatrica. 1996; 85 916-918.

  269. Fukuda Y, Kimura A, Hoshino S, Shintaku S, Sakaguchi T, Asahara T, Sakaki M, Sumimoto R, Tashiro H, Furukawa M, Ohdan H, Yoshida T, Dohi K. HLA-DR8 subtyping by polymerase chain reaction (PCR)- DNA conformation polymorphism (DCP) analysis: a simple and practical genotyping method Hiroshima Med Sci. 1996; 45 85-92.

  270. Date Y, Kimura A, Kato Y, Sasazuki T. DNA typing of HLA-A gene - population study and identification of four new alleles in Japanese Tissue Antigens. 1996; 47 93-101.

  271. Yasunaga S, Kimura A, Hamaguchi K, Roenningen KS, Sasazuki T. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM) Tissue Antigens. 1996; 47 37-48.

  272. Aerbajinai W, Tsuchiya T, Kimura A, Yasukochi Y, Numano F. HLA class II DNA typing in Buerger's disease Int J Cardiol. 1996; 54S 197-202.

  273. Koga Y, Toshima H, Kimura A, Harada H, Koyanagi T, Nishi H, Nakata M, Imaizumi T. Clinical manifestations of hypertrophic cardiomyopathy with mutations in the cardiac beta-myosin heavy chain and cardiac troponin T genes J Cardiac Failure. 1996; 2S 97-103.

  274. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Ito H, Dohi K. Assessment of microchimerism in rat liver transplantation by polymerase chain reaction Hepatology. 1996; 23 828-834.

  275. Tamai H, Sudo T, Kimura A, Matsubayashi S, Kuma K, Nagataki S. Association between the DRB108032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease Ann Internal Med. 1996; 124 490-494.

  276. Koyanagi T, Koga Y, Nishi H, Toshima H, Sasazuki T, Imaizumi T, Kimura A. DNA typing of HLA class II genes in Japanese patients with rheumatic heart disease J Mol Cell Cardiol. 1996; 28 1349-1353.

  277. Hirayama K, Samah MZA, Sulaiman LH, Kimura A, Joo OK, Kikuchi M, Abdullah NH, Kojima S, Wah MJ. Molecular analysis of HLA-B in the Malaysian aborigines Tissue Antigens. 1996; 48 692-697.

  278. Maruya E, Ishikawa Y, Lin L, Tokunaga K, Kimura A, Nita H, Yokoyama S, Saji H. Allele typing of HLA-A10 group by nested-PCR-low ionic strength single strand conformation polymorphism and a novel A26 allele (A26KY, A2605) Hum Immunol. 1996; 50 140-147.

  279. Shintaku S, Fukuda Y, Kimura A, Hoshino S, Asahara T, Dohi K. HLA-A and -B genotyping in living related one haploidentical kidney transplantation Jpn J Med Sci Biol. 1996; 49 187-200.

  280. Kimura A, Kitamura H, Date Y, Numano F. Comprehensive analysis of HLA genes in Takayasu arteritis in Japan Int J Cardiol. 1996; 54S 65-73.

  281. Hori T, Kamikawaji N, Kimura A, Sone T, Komiyama N, Komiyama S, Sasazuki T. Japanese ceder pollinosis and HLA-DP5 Tissue Antigens. 1996; 47 485-491.

  282. Muto M, Date Y, Ichimiya M, Mori K, Kamikawaji N, Kimura A, Sasazuki T, Asagami C. Significance of antibodies to streptococcal M protein in psoriatic arthritis and their association with HLA-A0207 Tissue Antigens. 1996; 48 645-650.

  283. Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E. Mutation rate varies among alleles at a microsatellite locus: phylogenic evidence Proc Natl Acad Sci USA. 1996; 93 15285-15288.

  284. Mukai T, Kimura A, Ishibashi H, Sasazuki T, Sata M, Maruyama T, Sakai H, Niho Y. Association of HLA-DRB10803 and 1602 with the susceptibility to primary biliary cirrhosis Intrenat Hepatol Commun. 1995; 3 207-212.

  285. Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, Albert ED. Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter Tissue Antigens. 1995; 45 317-321.

  286. Dong RP, Kamikawaji N, Toida N, Fujita Y, Kimura A, Sasazuki T. Characterization of T cell epitopes in streptococcal M12 protein restricted by HLA-DP9 J Immunol. 1995; 154 4536-4545.

  287. Mignot E, Kimura A, Abbal M, Thorsby E, Lin X, Voros A, Macaubas C, Bouissou F, Sollid LM, Cambon-Thomsen A, Yasunaga S, Grumet FC. DQCAR microsatellite polymorphisms in three selected HLA Class II associated diseases Tissue Antigens. 1995; 46 299-304.

  288. Sudo T, Kamikawaji N, Kimura A, Date Y, Savoie CJ, Nakashima H, Furuichi E, Kuhara S, Sasazuki T. Differences in MHC-class I self peptide repertoires among HLA-A2 subtypes J Immunol. 1995; 155 4749-4756.

  289. Nishi H, Kimura A, Harada H, Koga Y, Adachi K, Matsuyama K, Koyanagi T, Imaizumi T, Toshima H, Sasazuki T. A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy Circulation. 1995; 91 2911-2915.

  290. Petronzelli F, Kimura A, Ferrante P, Mazzilli MC. Polymorphism in the upstream regulatory region of DQA1 gene in the Italian population Tissue Antigens. 1995; 45 258-263.

  291. Nakajima A, Matsuhashi N, Kodama T, Yazaki Y, Takazoe M, Kimura A. HLA-linked disease susceptibility gene and disease resistance gene in Crohn's disease Gastroenterol. 1995; 109 1462-1467.

  292. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K. Monitoring for engraftment of rat orthotopic liver transplantation by semiquantitative PCR Transpl Proc. 1995; 27 537-539.

  293. Fukuda Y, Kimura A, Hoshino S, Tashiro H, Furukawa M, Shintaku S, Hori H, Sasazuki T, Dohi K. Significance of the HLA-DQB1 matching in one-haplotype identical kidney transplant pairs and the matching analysis by the polymerase chain reaction (PCR)-heteroduplex-polymorphism method Tissue Antigens. 1995; 45 49-56.

  294. Nishi H, Koga Y, Koyanagi T, Harada H, Imaizumi T, Toshima H, Sasazuki T, Kimura A. DNA typing of HLA class II genes in Japanese patients with dilated cardiomyopathy J Mol Cell Cardiol. 1995; 27 2385-2392.

  295. Wan XL, Kimura A, Dong RP, Honda K, Tamai H, Sasazuki T. HLA-A and DRB4 genes in controlling the susceptibility to Hashimoto's thyroiditis Hum Immunol. 1995; 42 131-136.

  296. Shintaku S, Kimura A, Fukuda Y, Date Y, Tashiro H, Hoshino S, Furukawa M, Sasazuki T, Dohi K. Polymerase chain reaction-based HLA-A genotyping and its application to matching in kidney transplantation Transpl Proc. 1995; 27 689-692.

  297. Macaubas C, Hallmayer J, Kalil J, Kimura A, Yasunaga S, Grumet FC, Mignot E. Extensive polymorphism of a (CA)n microsatellite located in the HLA-DQA1/DQB1 class II region Hum Immunol. 1995; 42 209-220.

  298. Ohsako N, Tamai H, Sudo T, Mukuta T, Tanaka H, Kuma K, Kimura A, Sasazuki T. Clinical characteristics of subacute thyroiditis classified according to Human Leukocyte Antigen typing J Clin Endocrionol Metab. 1995; 80 3653-3656.

  299. Nakao M, Yamana H, Imai Y, Toh Y, Toh U, Kimura A, Yanoma S, Kakegawa T, Itoh K. HLA A2601-restricted cytotoxic T lymphocytes recognizing a peptide antigen expressed on squamous cell carcinoma Cancer Res. 1995; 55 4248-4252.

  300. Kato M, Takazawa K, Kimura A, R?egg JC, Amano K, Wang Y, Sasaki Y, Toyo-oka T. Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death Lancet. 1995; 345 1247.

  301. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Sakaguchi T, Fukukawa M, Shintaku S, Dohi K. Monitoring for engraftment following rat orthotopic liver transplantation by polymerase chain reaction Transpl Proc. 1994; 26 902-903.

  302. Otsuka S, Kimura A, Date Y, Koyanagi T, Kunstman E, Hirose M, Yamada Y, Noma A. Fatal transfusion-associated graft-versus-host disease Transfusion. 1994; 34 936-937.

  303. Haas JP, Kimura A, Andreas A, Hochberger M, Keller E, Brennler G, Bettinotti MP, Yao Z, Nevinny-Stickel C, Sierp G, Sasazuki T, Albert ED. Polymorphism in the upstream regulatory regions of DQA1 genes and DRB1, QAP, DQA1, DQB1 haplotypes in the German population Hum Immunol. 1994; 39 31-40.

  304. Konenkov V, Sartakova M, Kimura A. Oligonucleotide genotyping of HLA-DRB104 and HLA-DQB103 among Russians in west Siberia suffering from rheumatoid arthritis Exp Clin Immunogenet. 1994; 11 187-191.

  305. Esaki Y, Fukui Y, Sudo T, Yamamoto K, Inamitsu T, Nishimura Y, Hirokawa K, Kimura A, Sasazuki T. Role of human major histocompatibility complex DQ molecules in superantigenicity of Streptococcus-derived protein Infect Immun. 1994; 62 1228-1235.

  306. Fukuda Y, Tashiro H, Hoshino S, Kimura A, Dohi K. Identification of donor-derived cells in organ transplants by in vitro amplification of Y-chromosome gene using polymerase chain reaction Cell Transpl. 1994; 3S 27-28.

  307. Undlien DE, Hamaguchi K, Kimura A, Tuomilehto-Wolf E, Swai ABM, McLarty DG, Tuomilehto J, Thorsby E, Roenningen KS. IDDM susceptibility associated with polymorphisms in the insulin gene region - A study of Blacks, Caucasians and Orientals Diabetologia. 1994; 37 745-749.

  308. Nakano S, Tatsumoto T, Esaki T, Nakamura M, Baba E, Kimura A, Ohshima K, Niho Y. Characterization of a newly established human gallbladder carcinoma cell line In vitro Cell Dev Biol. 1994; 30A 729-732.

  309. Shintaku S, Fukuda Y, Tashiro H, Hoshino S, Dohi K, Kimura A. Simple and rapid HLA-DRB typing method for transplantation using polymerase chain reaction-sequence-specific primers in combination with DNA conformation polymorphism analysis Transpl Proc. 1994; 26 1893-1896.

  310. Fukuda Y, Hoshino S, Kimura A, Dohi K, Sasazuki T. Negative effect of HLA-DQ antigen compatibility (concordance) on the survival of kidney grafts Transpl Proc. 1994; 26 1887-1890.

  311. Hashimoto H, Nishimura Y, Dong RP, Kimura A, Sasazuki T, Yamanaka K, Takano Y, Murashima A, Kabasawa K, Hirose S. HLA antigens in Japanese patients with systemic lupus erythematosus Scand J Rheumatol. 1994; 23 191-196.

  312. Tamai H, Kimura A, Dong RP, Matsubayashi S, Kuma K, Nagataki S, Sasazuki T. Resistance to autoimmune thyroid disease is associated with HLA-DQ J Clin Endocrionol Metab. 1994; 78 94-97.

  313. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Sakaguchi T, Fukukawa M, Shintaku S, Dohi K. Monitoring for rejection and engraftment by means of the polymerase chain reaction after rat orthotopic liver transplantation Transplantation. 1994; 58 745-748.

  314. Shintaku S, Fukuda Y, Kimura A, Hoshino S, Tashiro H, Sasazuki T, Dohi K. DNA conformation polymorphism (DCP) analysis of DR52 associated HLA-DR antigens by polymerase chain reaction (PCR) - A simple, economical, and rapid examination for HLA matching in transplantation Jpn J Med Sci Biol. 1994; 46 165-181.

  315. Ishikawa Y, Tokunaga K, Lin L, Imanishi T, Saitou S, Kimura A, Kashiwase K, Akaza T, Tadokoro K, Juji T. Sequences of four splits of HLA-A10 group: Implication for serologic cross-reactivities and their evolution Hum Immunol. 1994; 39 220-224.

  316. Kimura A, Date Y, Sasazuki T. DNA typing of the HLA-A gene MHC & IRS. 1994; S1 13-22.

  317. Nishi H, Kimura A, Harada H, Adachi K, Koga Y, Sasazuki T, Toshima H. Possible gene dose effect of a mutant cardiac beta-myosin heavy chain gene on the clinical expression of hypertrophic cardiomyopathy Biochem Biophys Res Commun. 1994; 200 549-556.

  318. Yamamoto K, Fukui Y, Esaki Y, Inamitsu T, Sudo T, Yamane K, Kamikawaji N, Kimura A, Sasazuki T. Functional interaction between human histocompatibility leukocytes antigen (HLA) class II and mouse CD4 molecules in antigen recognition by T cells in HLA-DR and DQ transgenic mice J Exp Med. 1994; 180 165-171.

  319. Hoshino S, Kimura A, Fukuda Y, Hori H, Sasazuki T, Dohi K. A practical HLA-DRB and -DQB matching test in kidney transplantation Transpl Proc. 1993; 25 191-193.

  320. Honda K, Kimura A, Dong RP, Tamai H, Nagato H, Nishimura Y, Sasazuki T. Immunogenetic analysis of silicosis in Japan Am J Resp Cell Mol Biol. 1993; 8 106-111.

  321. Dong RP, Kimura A, Hashimoto H, Akizuki M, Nishimura Y, Sasazuki T. Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus Tissue Antigens. 1993; 41 20-25.

  322. Kimura A, Fukuda Y, Hori H, Hoshino S, Sasazuki T, Dohi K. PCR-SSCP analysis of HLA-DP genes and its application to matching study in transplantation Transpl Proc. 1993; 25 199-202.

  323. Kato A, Hirosawa S, Toyota S, Nakamura Y, Nishi H, Kimura A, Sasazuki T, Aoki N. Localization of the human alpha2-plasmin inhibitor gene (PLI) to 17p13 Cyogenet Cell Genet. 1993; 62 190-191.

  324. Fukui Y, Yamamoto K, Yokoyama N, Iwanaga T, Kurashima C, Esaki Y, Kimura A, Akashi T, Hirokawa K, Sasazuki T. Restricted expression of transgenic HLA-DRA gene in thymic epithelial cells and its role in aquisition of T cell tolerance to self-superantigens and processed DR?-derived peptide Eur J Immunol. 1993; 23 1678-1686.

  325. Bettinotti PM, Kolek A, Brennler G, Haas P, Paul C, Hochberger H, Bartova A, Kimura A, Sasazuki T, Albert ED. Polymorphism of the 5' flanking region of the HLA-DQA1 gene in Coeliac disease Eur J Immunogenet. 1993; 20 399-407.

  326. Harada H, Kimura A, Nishi H, Sasazuki T, Toshima H. A missense mutation of cardiac beta-myosin heavy chain gene linked to familial hypertrophic cardiomyopathy in affected Japanese families Biochem Biophys Res Commun. 1993; 194 791-798.

  327. Yao Z, Kimura A, Hartung K, Haas PJ, Volgger A, Brennler G, Benisch J, Albert ED. LE study group members: Polymorphism of the DQA1 promoter region (QAP) and DRB1, QAP, DQA1, DQB1 haplotypes in systemic lupus erythematosus Immunogenetics. 1993; 38 421-429.

  328. Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T. DNA typing of HLA-B gene in Takayasu's arteritis Tissue Antigens. 1993; 42 87-90.

  329. Fukui Y, Esaki Y, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T. T cell repertoire in a strain of transgenic C57BL/6 mice with the HLA-DRA gene on the X chromosome Immunogenetics. 1993; 37 204-211.

  330. Dong RP, Kimura A, Ohkubo R, Shinagawa H, Tamai H, Nishimura Y, Sasazuki T. HLA-A and DPB1 loci confer susceptibility to Graves' disease Hum Immunol. 1992; 35 165-172.

  331. Nishi H, Kimura A, Fukuda S, Kusukawa R, Kawamura K, Nimura Y, Nagano M, Yasuda H, Kawai C, Sugimoto T, Okada R, Yazaki Y, Tanaka H, Harumi K, Koga Y, Sasazuki T, Toshima H. Genetic analysis of dilated cardiomyopathy: HLA and immunoglobulin genes may confer susceptibility Jpn Circ J. 1992; 56 1054-1061.

  332. Matsumori A, Tominaga M, Kawai C, Yasuda H, Kawaguchi H, Sano H, Kohya T, Nakayama H, Kuboki Y, Yasui S, Sugishita Y, Nagano M, Okada R, Handa S, Yoshikawa T, Harumi K, Nakamura H, Ohsuzu F, Hayakawa H, Munakata K, Nobuoka S, Murayama M, Sato T, Takeshi M, Horie T, Fujita T, Machii K, Hirai H, Yabe Y, Sugimoto T, Iizuka M, Nonomura Y, Yazaki Y, Toyooka T, Yamazaki N, Izumi T, Sekiguchi M, Watanabe T, Motomura H, Morimoto S, Mizuno Y, Ozawa Y, Kawamura K, Kitabatake A, Nagata S, Fujita T, Omae T, Nimura Y, Nishio I, Arita M, Yokota Y, Yokoyama M, Inoh T, Hayakawa M, Matsuo H, Nakajima S, Kusukawa R, Takeshita A, Urabe Y, Kimura A, Toshima H, Koga Y, Kuroiwa A, and Tanaka H. A questionnaire study of ?-adrenergic blokade in dilated cardiomyopathy in Japan Jpn Circ J. 1992; 56 767-775.

  333. Dong RP, Kimura A, Sasazuki T. Sequence analysis of three novel DRw14-DRB1 alleles Immunogenetics. 1992; 36 130-133.

  334. Hirashima M, Ono T, Nakao M, Nishi H, Kimura A, Nomiyama H, Hamada F, Yoshida MC, Shimada K. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17 DNA Sequence. 1992; 3 203-212.

  335. Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene Immunogenetics. 1992; 36 (5): 319-325.

  336. Kimura A, Dong RP, Harada H, Sasazuki T. DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA Tissue Antigens. 1992; 40 5-12.

  337. Nishi H, Kimura A, Harada H, Toshima H, Sasazuki T. Novel missense mutation in cardiac beta-myosin heavy chain gene found in a Japanese patient with hypertrophic cardiomyopathy Biochem Biophys Res Commun. 1992; 188 379-387.

  338. Dong RP, Kimura A, Numano F, Nishimura Y, Sasazuki T. HLA-linked susceptibility and resistance to Takayasu arteritis Heart and Vessels. 1992; 7S 73-80.

  339. Nishi H, Kimura A, Harada H, Hayashi Y, Nakamura M, Sasazuki T. Novel variant transthyretin gene (Ser50 to Ile) in familial cardiac amyloidosis Biochem Biophys Res Commun. 1992; 187 460-466.

  340. Yoshida M, Kimura A, Numano F, Sasazuki T. Polymerase chain reaction based analysis of polymorphism in the HLA-B gene Hum Immunol. 1992; 34 257-266.

  341. Harada H, Kimura A, Dong RP, Xu XP, Bhatia K, Sasazuki T. Sequencing and population analysis of four novel HLA-DPA1 alleles Hum Immunol. 1992; 35 173-178.

  342. Hatae K, Kimura A, Ohkubo R, Watanabe H, Erlich HA, Ueda K, Nishimura Y, Sasazuki T. Genetic control of non-responsiveness to hepatitis B virus vaccine by an extended HLA haplotype Eur J Immunol. 1992; 22 1899-1905.

  343. Oedum N, Yoshizumi H, Okamoto Y, Kamikawaji N, Kimura A, Nishimura Y, Sasazuki T. Signal transduction by HLA class II molecules in human T cells: Induction of LFA-1-dependent and independent adhesion Hum Immunol. 1992; 35 71-84.

  344. Dong RP, Kimura A, Numano F, Yajima M, Hashimoto Y, Kishi Y, Nishimura Y, Sasazuki T. HLA-DP antigen and Takayasu arteritis Tissue Antigens. 1992; 39 106-110.

  345. Hoshino S, Kimura A, Fukuda Y, Dohi K, Sasazuki T. Polymerase chain reaction-single strand conformation polymorphism analysis of polymorphisms in DPA1 and DPB1 gene - A simple, economical and rapid method for histocompatibility testing Hum Immunol. 1992; 33 98-107.

  346. Hansen T, Roenningen KS, Ploski R, Kimura A, Thorsby E. Coding region polymorphisms of human T cell receptor Vb6-9 and Vb21-4 Scand J Immunol. 1992; 36 285-290.

  347. Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants Eur J Immunol. 1991; 21 (10): 2341-2347.

  348. Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. HLA-DQ restricted CD4+ T cells specific to streptococcal antigen exist in low responder but not in high responder J Immunol. 1991; 146 (8): 2560-2567.

  349. Tamaki K, Yamamoto T, Uchihi R, Katsumata Y, Kondo K, Mizuno S, Kimura A, Sasazuki T. Frequency of HLA-DQA1 alleles in the Japanese population Hum Hered. 1991; 41 209-214.

  350. Nishimura Y, Kamikawaji N, Fujisawa K, Yoshizumi H, Yasunami M, Kimura A, Sasazuki T. Genetic control of immune response and disease susceptibility by the HLA-DQ gene Res Immunol. 1991; 142 (5-6): 459-466.

  351. Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. Expression of human MHC, HLA-DQw6 genes alter the immune response in C57BL/6 mice J Immunol. 1990; 145 (1): 353-360.

  352. Urabe K, Kimura A, Harada F, Iwanaga T, Sasazuki T. Gene conversion in 21-hydroxylase genes Am J Hum Genet. 1990; 46 1178-1186.

  353. Sasazuki T, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Nishimura Y. Expression and function of human major histocompatibility complex HLA-DQw6 genes in the C57BL/6 mouse Cold Spring Harbor Symp Quant Biol. 1989; 54 (Pt 1): 513-520.

  354. Fukui Y, Nishimura Y, Iwanaga T, Kimura A, Inamitsu T, Hanaoka Y, Kitagawa T, Sasazuki T. Analysis of glucosuria and insulitis in NOD mice expressing HLA-DQw6 molecule J Immunogenet. 1989; 16 445-453.

  355. Israel A, Kimura A, Kieran M, Yano O, Kanellopoulos J, Le Bail O, Kourilsky P. A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta-2-microglobulin genes Proc Natl Acad Sci USA. 1987; 84 2653-2657.

  356. Tsukamoto K, Yasunami M, Kimura A, Inoko H, Ando A, Hirose T, Inayama S, Sasazuki T. DQw1beta gene from HLA-DR2-Dw12 consists of six exons and expresses multiple DQw1? polypeptides through alternative splicing Immunogenetics. 1987; 25 (2): 343-346.

  357. Harada F, Kimura A, Iwanaga T, Shimozawa K, Yata J, Sasazuki T. Gene conversion-like events cause steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia Proc Natl Acad Sci USA. 1987; 84 8091-8094.

  358. Israel A, Kimura A, Fournier A, Fellous M, Kourilsky P. Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H-2 gene Nature. 1986; 322 743-746.

  359. Kimura A, Israel A, Le Bail O, Kourilsky P. Detailed analysis of the mouse H-2 Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression Cell. 1986; 44 261-272.

  360. Matsunaga E, Kimura A, Yamada H, Fukumaki Y, Takagi Y. A novel deletion in delta-beta-thalassemia found in Japan Biochem Biophys Res Commun. 1985; 126 185-191.

  361. Kimura A, Takagi Y. A frameshift addition causes silencing of the delta-globin gene in an old world monkey, an anubis (Papio doguera) Nucl Acids Res. 1984; 11 2541-2550.

  362. Kimura A, Ohta Y, Fukumaki Y, Takagi Y. A fusion gene in man: DNA sequence analysis of the abnormal globin gene of Hemoglobin Miyada Biochem Biophys Res Commun. 1984; 119 968-974.

  363. Kimura A, Matsunaga E, Takihara Y, Nakamura T, Takagi Y, Lin S, Lee H. Structural analysis of a beta-thalassemia gene found in Taiwan J Biol Chem. 1983; 258 2748-2749.

  364. Kimura A, Shimada K, Takagi Y. Re-examination of the ColE1 DNA regions essential for autonomous replication and their functions J Biochem. 1982; 92 95-103.

  365. Ozaki LS, Kimura A, Shimada K, Takagi Y. ColEl vectors for direct selection of cells carrying a hybrid plasmid J Biochem. 1982; 91 1151-1162.

  366. Kimura A, Matsunaga E, Ohta Y, Fujiyoshi T, Matsuo T, Nakamura T, Imamura T, Yanase T, Takagi Y. Structure of cloned delta-globin genes from a normal subject and a patient with delta-thalassemia - Sequence polymorphisms found in the delta-globin gene region of Japanese individuals Nucl Acids Res. 1982; 10 5725-5732.

  367. Koizumi Shinya, Naruse Taeko K., Kimura Akinori. A haplotype of Toll-like receptor 1 is associated with resistance to Buerger disease in Japanese(和訳中) MHC: Major Histocompatibility Complex. 2019.12; 26 (3): 189-194. ( 医中誌 )

  368. Kikkawa Eri, Tanaka Masafumi, Tsuda Tomi T., Murata Koichi, Naruse Taeko K., Kimura Akinori. Genome structure of MHC Class II β gene from Humboldt penguin(Spheniscusnhumboldti)(和訳中) MHC: Major Histocompatibility Complex. 2019.12; 26 (3): 195-203. ( 医中誌 )

  369. 木村 彰方. HLAの基礎知識 認定試験問題から MHC: Major Histocompatibility Complex. 2019.09; 26 (2Suppl.): 73. ( 医中誌 )

  370. 木村 彰方. 【循環器症候群(第3版)-その他の循環器疾患を含めて-】心筋疾患 遺伝性心筋疾患 日本臨床. 2019.09; 別冊 (循環器症候群I): 132-137. ( 医中誌 )

  371. 木村 彰方. HLAの基礎知識―認定試験問題から― MHC: Major Histocompatibility Complex. 2019.08; 26 (2): 84-94. ( DOI )

  372. 谷本 幸介, 成瀬 妙子, 木村 彰方. ヒト以外の動物種を対象としたNGSによるMHCタイピング法 MHC: Major Histocompatibility Complex. 2019.08; 26 (2): 115-123. ( 医中誌 )

  373. 木村 彰方. 【心不全(第2版)上-最新の基礎・臨床研究の進歩-】 心不全の基礎研究 病因遺伝子 心筋症の原因遺伝子異常 日本臨床. 2018.12; 76 (増刊9 心不全(上)): 391-399. ( 医中誌 )

  374. 木村 彰方. HLAの基礎知識(認定制度試験問題の解説を中心に) MHC: Major Histocompatibility Complex. 2018.09; 25 (2Suppl.): 73. ( 医中誌 )

  375. 木村 彰方. 【基礎科学の進歩】 心筋症における遺伝子解析の進歩 循環器専門医. 2018.08; 27 54-63. ( 医中誌 )

  376. 木村 彰方. 循環器疾患におけるプレシジョンメディシン 遺伝子異常と心筋疾患 心臓. 2018.04; 50 (4): 438-449. ( 医中誌 )

  377. 寺尾 知可史, 吉藤 元, 松村 貴由, 成瀬 妙子, 石井 智徳, 小室 一成, 木村 彰方, 磯部 光章, 三森 経世, 松田 文彦. 高安動脈炎の新規関連領域及びHLAとLILRA3領域の相互作用の同定 日本内科学会雑誌. 2018.02; 107 (Suppl.): 267. ( 医中誌 )

  378. 成瀬 妙子, 木村 彰方. MICA-129多型は高安病の感受性因子である MHC: Major Histocompatibility Complex. 2017.10; 24 (2Suppl.): 78. ( 医中誌 )

  379. 安 健博, 永石 宇司, 渡部 太郎, 成瀬 妙子, 渡辺 守, 木村 彰方. 炎症性腸疾患の病態形成におけるMKL1の役割 MHC: Major Histocompatibility Complex. 2017.10; 24 (2Suppl.): 91. ( 医中誌 )

  380. 谷本 幸介, 成瀬 妙子, 俣野 哲朗, 木村 彰方. 次世代シーケンサー(NGS)を用いたアカゲザルMHCクラスI遺伝子群タイピング法の開発 MHC: Major Histocompatibility Complex. 2017.10; 24 (2Suppl.): 79. ( 医中誌 )

  381. 吉川 枝里, 田中 正史, 津田 とみ, 村田 浩一, 成瀬 妙子, 木村 彰方. フンボルトペンギンMHCクラスIIβ遺伝子のゲノム構造 MHC: Major Histocompatibility Complex. 2017.10; 24 (2Suppl.): 92. ( 医中誌 )

  382. 木村 彰方. 【患者さんからよく尋ねられる内科診療のFAQ】(第4章)循環器 拡張型心筋症って,私の子どもにも遺伝しますか? [33歳 男性,拡張型心筋症] 内科. 2017.09; 120 (3): 592-594. ( 医中誌 )

  383. 中野 知哉, 尾上 健児, 坂口 泰弘, 有村 卓朗, 木村 彰方, 斎藤 能彦. 家族性拡張型心筋症に対する抗アンドロゲン療法の効果 日本内分泌学会雑誌. 2017.01; 92 (3): 901. ( 医中誌 )

  384. 吉川 枝里, 津田 とみ, 細道 一善, 津田 道雄, 猪子 英俊, 木村 彰方, 成瀬 妙子, 村田 浩一. MHCクラスI遺伝子におけるペンギン科7種の分子進化学的解析 MHC. 2015.12; 22 (3): 156-163. ( DOI )

  385. Hayashi T, Kimura A. Development of personalized medicine and therapy for cardiomyopathy based on the pathogensis: Identification of novel disease causative gene by comprehensive mutation analysis. J. Seizon and Life Sci.. 2014; 25 221-227.

  386. 成瀬 妙子、木村 彰方. 実験動物サルのMHCクラスI多様性 MHC. 2013.01; 20 (1): 35-44.

  387. 櫻井 大祐, 菅野 裕美子, 長谷 英徳, 小端 哲二. 【B細胞機能の修飾因子】 TACIによるB細胞応答の制御 臨床免疫・アレルギー科. 2009.02; 51 (2): 105-111. ( 医中誌 )

  388. 櫻井 大祐, 川崎 綾, 小端 哲二, 土屋 尚之. 【TNFファミリーの分子リウマチ学 基礎から臨床へ】 BAFF,APRILの機能と自己免疫疾患における役割 分子リウマチ. 2007.11; 4 (4): 307-313. ( 医中誌 )

  389. 櫻井 大祐, 長谷 英徳, 小端 哲二. 【リンパ球の生存維持機構】 メモリーB細胞の生存維持とBAFF/BLyS 臨床免疫. 2005.11; 44 (5): 508-514. ( 医中誌 )

  390. 櫻井 大祐. 膠原病・リウマチ学 関節リウマチ滑膜におけるIdファミリーの役割 医学のあゆみ. 2005.08; 214 (9): 754-755. ( 医中誌 )

  391. 小端 哲二, 櫻井 大祐, 長谷 英徳. 【リンパ球の機能発現と共刺激分子】 濾胞樹状細胞のBAFF/BLySとCD19とによる胚中心B細胞の選択増強 臨床免疫. 2004.10; 42 (4): 403-408. ( 医中誌 )

  392. 櫻井 大祐, 土屋 尚之. 【RAと骨破壊】 RA疾患感受性遺伝子,増悪関連遺伝子研究の現状 THE BONE. 2002.08; 16 (5): 463-468. ( 医中誌 )

  393. 櫻井 大祐, 土屋 尚之, 徳永 勝士. 【予防医学のミレニアム 遺伝子診断の動向とそれに伴う問題点】 ミレニアム医学の構築 感染症・アレルギー リウマチ・膠原病の遺伝子診療に向けて 現状と展望 医学のあゆみ. 2001.06; 197 (13): 1094-1099. ( 医中誌 )

▼全件表示

講演・口頭発表等 【 表示 / 非表示

  1. Akinori Kimura, Taeko K. Naruse, Daisuke Sakurai, Jianbo An, Hiroshi Terunuma, Emi E. Nakayama, Tatsuo Shioda, Gaurav Sharma, Narinder Mehra, Gurvinder Kaur. IkBL regulates susceptibility to HIV-1 infection. The 13th International Congress of Human Genetics 2016.04.04 Kyoto, Japan

  2. Taeko K. Naruse, Daisuke Sakurai, Hitoshi Ohtani, Hiroshi Terunuma, Yasumasa Iwatani, Wataru Sugiura, Gaurav Sharma, Narinder Mehra, Gurvinder Kaur, Akinori Kimura. APOBEC3H polymorphisms are associated with susceptibility to HIV-1 infection and development of AIDS in Asian populations. The 13th international Congress of Human Genetics 2016.04.04 Kyoto, Japan

  3. Akinori Kimura, Takuro Arimura, Kenji Onoue, Taisuke Ishikawa, Yoshihiko Saito. Molecular mechanism of gender difference in heart failure caused by lamin A/C mutations. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.21 Tokyo

  4. 成瀬妙子、大谷仁志、安健博、木村彰方. OAS1はHIV-1疾患感受性を制御する. 日本人類遺伝学会 第63回大会 2018.10.11 横浜

  5. 木村彰方. 教育講演:HLAの基礎知識(認定制度試験問題の解説を中心に). 第27回 日本組織適合性学会大会 2018.09.23 松本

  6. 木村彰方. 学会賞受賞講演:私とHLA. 第27回 日本組織適合性学会大会 2018.09.22 松本

  7. 成瀬妙子、木村彰方. 抑制型NKレセプター(CD94/NKG2A)リガンドHLA-Eの疾患感受性解析. 第27回 日本組織適合性学会大会 2018.09.22 松本

  8. 谷本幸介、成瀬妙子、木村彰方. 次世代シーケンサー(NGS)によるアカゲザルMHCクラスI遺伝子群新規アレル藍ピングの試み. 第27回 日本組織適合性学会大会 2018.09.22 松本

  9. 成瀬妙子、木村彰方. MICA-129多型は炎症性自己免疫疾患の感受性因子である. 日本人類遺伝学会 第62回大会 2017.11.15

  10. Yoshihiro Noguchi, Shin-ya Nishio, Koichiro Wasano, Taro Fujikawa, Akinori Kimura.. A duplication mutation in HOXA2 causes autosomal dominant nonsyndromic mixed hearing loss and middle ear anomaly. 日本人類遺伝学会 第62回大会 2017.11.15 神戸

  11. 木村彰方. 教育講演:技術者認定制度試験問題の解説. 第26回 日本組織適合性学会大会 2017.10.29 広島

  12. 吉川枝里、田中正史、津田とみ、村田浩一、成瀬妙子、木村彰方. フンボルトペンギンMHCクラスIIβ遺伝子のゲノム構造. 第26回 日本組織適合性学会大会 2017.10.28

  13. 安健博、永石宇司、渡部太郎、成瀬妙子、渡辺守、木村彰方. 炎症性腸疾患の病態形成におけるMKL1の役割. 第26回 日本組織適合性学会大会 2017.10.28 広島

  14. 谷本幸介、成瀬妙子、俣野哲朗、木村彰方. 次世代シーケンサー(NGS)を用いたアカゲザルMHCクラスI遺伝子群タイピング法の開発. 第26回 日本組織適合性学会大会 2017.10.28 広島

  15. 成瀬妙子、木村彰方. MICA-129多型は高安病の感受性因子である. 第26回 日本組織適合性学会大会 2017.10.28 広島

  16. Teruki Sato, Hiroyuki Watanabe, Tomokazu Yamaguchi, Akinori Kimura, Akiyoshi Fukamizu, Josef Penninger, Reversade Bruno, Hiroshi Ito, Yumiko Imai.. ELABELA, a novel APJ ligand, inhibits pressure overload- and angiotensin II-induced cardiac remodeling. 第21回 日本心不全学会学術集会 2017.10.14 秋田

  17. Haruhito Harada, Ikuya Nonaka, Ken Kusaba, Hirofumi Nishi, Yasutoshi Kog, Yasunori Koga, Takeharu Hayashi, Akinori Kimura.. A miserable phenotype of hypertrophic cardiomyopathy carrying a novel homozygous missense mutation of desmin gene. 第21回 日本心不全学会学術集会 2017.10.13 秋田

  18. Akinori Kimura. Genetic basis and molecular pathogenesis of primary cardiomyopathy. 第21回 日本心不全学会学術集会 2017.10.12 秋田

  19. 木村 彰方. 拡張型心筋症における遺伝子異常と分子病態. 第3回心筋症研究会 2017.04.22 岐阜

  20. Inagaki N, Hayashi T, Takei Y, Chikamori T, Yamashina A、Kimura A. Genetic analysis of hypertrophic cardiomyopathy with mid-ventricular obstruction phenotype. 第81回日本循環器学会 2017.03.18 金沢

  21. Paku Y, Watanabe M, Iwasaki Y, Kobayashi M, Inagaki N, Hirayama K, Hayashi T, Kimura A, Yamashina A. A TTN frameshift mutation found in a patient with dilated cardiomyopathy. 第81回日本循環器学会 2017.03.17 金沢

  22. 成瀬妙子、木村彰方. MICA-129多型は炎症性自己免疫疾患の感受性因子か?. 第25回 日本組織適合性学会 2016.10.24 札幌

  23. 志田壽利、加藤誠一、保富康宏、松尾和浩、三浦智行、五十嵐樹彦、張険峰、井上誠、成瀬妙子、木村彰方. HIV−1ワクチン開発とその課題. 第25回 日本組織適合性学会 2016.10.24 札幌

  24. 渡邊俊介、義久精臣、安齋文弥、菅野優紀、上岡正志、鈴木聡、及川雅啓、小林淳、國井浩行、林丈晴、木村彰方、竹石恭知. αトロポミオシン1(TPM1)遺伝子にミスセンス変異を伴った若年性肥大型心筋症の一家系. 第2回 日本心筋症研究会 2016.05.14 松本

  25. 林 丈晴、谷本幸介、木村彰方. 若年、小児発症の肥大型及び拘束型心筋症の原因遺伝子解析. 第2回 日本心筋症研究会 2016.05.14 松本

  26. 木村彰方. 心筋症の遺伝学. 日本人類遺伝学会第60回大会 2015.10.17 東京

  27. 林丈晴、谷本幸介、木村彰方. 若年及び小児の肥大型、拘束型心筋症の遺伝子変異解析. 日本人類遺伝学会第60回大会 2015.10.15 東京

  28. 成瀬妙子、中山英美、安健博、Gaurav Sharma、Narinder Mehra、塩田達雄、Gurvinder Kaur、木村彰方. IkBLによるHIV-1感染感受性の制御. 日本人類遺伝学会第60回大会 2015.10.15 東京

  29. 稲垣夏子、林丈晴、武井康悦、近森大志郎、山科章、木村彰方. 心室中部閉塞型肥大型心筋症の病因変異探索. 日本人類遺伝学会第60回大会 2015.10.15

  30. 成瀬妙子、櫻井大祐、安健博、中山英美、塩田達雄、Gaurav Sharma、Narinder Mehra、Gurvinder Kaur、木村彰方. IkBLはHIV-1感染感受性を制御する. 第24回日本組織適合性学会大会 2015.09.10 水戸

  31. 木村彰方,櫻井大祐,成瀬妙子,大谷仁志,Gaurav Sharma, Narinder Mehra, Gurvinder Kaur. APOBE3HはHIV-1感染感受性およびAIDS発症感受性を制御する. 第24回日本組織適合性学会大会 2015.09.10 水戸

  32. 木村彰方. 肥大型心筋症の発症機序. 第51回日本小児循環器学会総会 2015.07.16 東京

  33. 中村碧、高原悠佑、松岡佐織、三浦智行、小柳義夫、成瀬妙子、木村彰方、俣野 哲朗. 抗HIV 薬投与下の治療ワクチン接種により誘導されるCD8 陽性T 細胞のSIV 複製. 第28回日本エイズ学会学術集会 2014.12.05 大阪

  34. 櫻井大祐, 今橋真弓, 岩谷靖雅, 大谷仁志, 成瀬妙子, 照沼裕, 杉浦亙, 木村彰方. APOBEC3HハプロタイプとHIV-1感染およびAIDS発症との関連. 日本人類遺伝学会第59回大会 2014.11.22 東京

  35. 成瀬妙子、飯塚淳次、明里宏文、俣野哲朗、木村彰方. 霊長類におけるULBP5/RAET1-G遺伝子群の進化. 日本人類遺伝学会第59回大会 2014.11.21 東京

  36. 稲垣夏子、林丈晴、武井康悦、近森大志郎、谷本幸介、山科章、木村彰方. 心室中部閉塞型肥大型心筋症の病因変異探索. 日本人類遺伝学会第59回大会 2014.11.20 東京

  37. 林丈晴、谷本幸介、木村彰方. 遺伝性心筋症変異スクリーニングシステムの構築. 日本人類遺伝学会第59回大会 2014.11.20 東京

  38. 木村彰方. 心不全・突然死の遺伝子. 第9回 四大学連合文化講演会 2014.10.10 東京

  39. 木村彰方. IkBLによる免疫制御と感染制御. 第23回 日本組織適合性学会大会 2014.09.14 長崎

  40. 成瀬妙子、飯塚淳次、明里宏文、俣野哲朗、木村彰方. 霊長類におけるULBP/RAET1遺伝子群の進化と特徴. 第23回日本組織適合性学会大会 2014.09.14 長崎

▼全件表示

受賞学術賞 【 表示 / 非表示

  • 日本組織適合性学会賞,日本組織適合性学会,2019年09月

  • 日本人類遺伝学会賞,日本人類遺伝学会,2005年09月

その他業績 【 表示 / 非表示

  • 「コロナ制圧タスクフォース」 COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 -重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する-,2022年08月

  • 「コロナ制圧タスクフォース」 COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 -アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見-,2022年08月

  • 「デルタ株の特徴が追加された国内由来オミクロン株 BA.2 系統の市中感染事例を初めて確認」 〜第6波長期化への懸念〜 ― 医科歯科大 新型コロナウイルス全ゲノム解析プロジェクト 第13報 ―,2022年05月

  • 「デルタ株の特徴に類似した変異が追加された 国内由来BA.2系統の市中感染事例をさらに確認」 〜第6波の下げ止まりから感染再拡大(第7波)への懸念〜 ― 医科歯科大 新型コロナウイルス全ゲノム解析プロジェクト 第14報 ―,2022年05月

  • 「新たな変異を有するオミクロン系統株を含むBA.1.1系統株の流行拡大、 およびBA.2系統株への置き換わりに影響をおよぼす可能性」 ― 医科歯科大 新型コロナウイルス全ゲノム解析プロジェクト 第12報 ―,2022年02月

  • 「オミクロン系統株:BA.2の新たな市中感染、および本邦において長期間存続しているデルタ系統株へのさらなる市中感染事例を確認」~医科歯科大 新型コロナウイルス全ゲノム解析プロジェクト 第11報~,2022年01月

  • 「北米地域で確認されているオミクロン系統株の本邦市中流行、および市中に長期間存続しているデルタ系統株への感染事例を確認」~医科歯科大 新型コロナウイルス全ゲノム解析プロジェクト 第10報~ ,2022年01月

  • 世界最大の新型コロナウイルス感染症のゲノムワイド関連解析にアジア最大のグループとして貢献-新型コロナウイルス感染症の重症化に関わる遺伝子多型を同定-,2021年07月

  • 「コロナ制圧タスクフォース」日本人集団における新型コロナウイルス感染症重症化因子の有力候補を発見-アジア最大のグループとして新型コロナウイルス感染症国際ゲノム研究にも大きな貢献- ,2021年05月

  • 共同研究グループ「コロナ制圧タスクフォース」発足 -新型コロナウイルス感染症の遺伝学的知見に基づいたCOVID-19粘膜免疫ワクチンの研究開発を促進-,2020年05月

  • 東京都と 「創薬・医療系オープンイノベーションに資する大学保有機器等の共用に関する協定」を締結,2019年07月

  • 「 MRTF-Aはマクロファージ機能を制御して動脈硬化形成に関わる 」 ― マクロファージ機能に着目した新たな治療法の開発に期待 ―,2019年05月

    Journal of Molecular and Cellular Cardiology

  • 「拡張型心筋症の原因変異が分子ばねタンパク質の発現に影響するしくみを解明」 モデルマウスによる病態解明と治療法開発へ前進 ―,2018年06月

    Scientific Reports

  • 「心不全と不整脈を来す心筋症の新たなモデルマウスを作製」 Rhoキナーゼ阻害剤による心不全治療の可能性を示唆 ―,2018年04月

    American Journal of Physiology-Heart and Circulation Physiology

  • 「炎症性腸疾患発症感受性が高い新たなモデルマウスを樹立」,2017年10月

    Scientific Reports

▼全件表示

 

担当授業科目(学内) 【 表示 / 非表示

  • 遺伝学(医学部保健衛生学科)

  • 歯科医療と遺伝疾患(歯学部歯学科)

  • 免疫学II(HLAと疾患)(医学部医学科)

担当授業科目(学外) 【 表示 / 非表示

  • 調節系ユニット(遺伝分野),埼玉医科大学

  • 免疫学(MHC),聖マリアンナ医科大学

社会貢献活動 【 表示 / 非表示

  • コロナ制圧タスクフォースについて,日本テレビ,News every. news zero,2020年06月23日 - 2020年06月24日

  • コロナ制圧タスクフォース 新型コロナ重症化の要因 遺伝子解析 ,讀賣テレビ放送,報道番組「ミヤネ屋」,2020年06月04日 - 2020年06月05日